F Galli

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. ncbi request reprint Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells
    Carmela Conte
    University of Perugia, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, Via del Giochetto, 06126 Perugia, Italy
    Ann N Y Acad Sci 1031:391-4. 2004
  2. ncbi request reprint Membrane rafts and redox therapies in cancer: a commentary on "Radioresistance of human carcinoma cells is correlated to a defect in raft membrane clustering"
    Francesco Galli
    Section of Applied Biochemistry and Nutritional Sciences, Department of Internal Medicine, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Free Radic Biol Med 43:678-80. 2007
  3. doi request reprint Oxidative stress and antioxidant therapy in cystic fibrosis
    Francesco Galli
    Department of Internal Medicine, Laboratory of Clinical Biochemistry and Nutrition, University of Perugia, Italy
    Biochim Biophys Acta 1822:690-713. 2012
  4. ncbi request reprint Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of alpha- and gamma-tocopherol in human plasma
    Francesco Galli
    Dept of Internal Medicine, Section of Applied and Clinical Biochemistry, University of Perugia, Italy corrected
    Free Radic Biol Med 32:333-40. 2002
  5. ncbi request reprint Glycoxidation and inflammatory markers in patients on treatment with PMMA-based protein-leaking dialyzers
    Francesco Galli
    Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy
    Kidney Int 67:750-9. 2005
  6. doi request reprint Do statins cause myopathy by lowering vitamin E levels?
    Francesco Galli
    Faculty of Pharmacy, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Med Hypotheses 74:707-9. 2010
  7. ncbi request reprint Vitamin E in uremia and dialysis patients
    Francesco Galli
    University of Perugia, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, Via del Giochetto, 06126 Perugia, Italy
    Ann N Y Acad Sci 1031:348-51. 2004
  8. ncbi request reprint Oxidative stress and reactive oxygen species
    Francesco Galli
    Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy
    Contrib Nephrol 149:240-60. 2005
  9. ncbi request reprint Interactions of polyphenolic compounds with drug disposition and metabolism
    Francesco Galli
    Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Via del Giochetto 06126, Perugia, Italy
    Curr Drug Metab 8:830-8. 2007
  10. ncbi request reprint A comparison between the antioxidant and peroxynitrite-scavenging functions of the vitamin E metabolites alpha- and gamma-carboxyethyl-6-hydroxychromans
    Francesco Galli
    Department of Internal Medicine, Section of Applied and Clinical Biochemistry, University of Perugia, Italy
    Int J Vitam Nutr Res 74:362-73. 2004

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells
    Carmela Conte
    University of Perugia, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, Via del Giochetto, 06126 Perugia, Italy
    Ann N Y Acad Sci 1031:391-4. 2004
    ..These early findings may suggest that the transformation of vitamin E to CEHC is mostly a detoxification mechanism useful to maintain the malignant properties of prostate cancer cells...
  2. ncbi request reprint Membrane rafts and redox therapies in cancer: a commentary on "Radioresistance of human carcinoma cells is correlated to a defect in raft membrane clustering"
    Francesco Galli
    Section of Applied Biochemistry and Nutritional Sciences, Department of Internal Medicine, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Free Radic Biol Med 43:678-80. 2007
  3. doi request reprint Oxidative stress and antioxidant therapy in cystic fibrosis
    Francesco Galli
    Department of Internal Medicine, Laboratory of Clinical Biochemistry and Nutrition, University of Perugia, Italy
    Biochim Biophys Acta 1822:690-713. 2012
    ..This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease...
  4. ncbi request reprint Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of alpha- and gamma-tocopherol in human plasma
    Francesco Galli
    Dept of Internal Medicine, Section of Applied and Clinical Biochemistry, University of Perugia, Italy corrected
    Free Radic Biol Med 32:333-40. 2002
    ..This GC/MS method provides a versatile and accurate mean for assessing carboxyethyl-hydroxychroman metabolites of vitamin E in plasma...
  5. ncbi request reprint Glycoxidation and inflammatory markers in patients on treatment with PMMA-based protein-leaking dialyzers
    Francesco Galli
    Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy
    Kidney Int 67:750-9. 2005
    ..The elimination of these and other large solutes by protein-leaking dialyzers (PLD) might help to correct the inflammatory status of maintenance hemodialysis (HD) patients...
  6. doi request reprint Do statins cause myopathy by lowering vitamin E levels?
    Francesco Galli
    Faculty of Pharmacy, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Med Hypotheses 74:707-9. 2010
    ..This hypothesis that needs to be further investigated, could suggest the need for precautionary measures during lipid lowering therapy, which include timely diagnosis and active prevention of vitamin E deficiency...
  7. ncbi request reprint Vitamin E in uremia and dialysis patients
    Francesco Galli
    University of Perugia, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, Via del Giochetto, 06126 Perugia, Italy
    Ann N Y Acad Sci 1031:348-51. 2004
    ..Although further studies are needed to confirm the clinical relevance of vitamin E therapy in HD, these findings might lead to recommending a higher vitamin E intake in these patients...
  8. ncbi request reprint Oxidative stress and reactive oxygen species
    Francesco Galli
    Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy
    Contrib Nephrol 149:240-60. 2005
    ..These technological advancements and the huge information available in literature represent in our time a challenge to further understand the clinical meaning of oxidative stress and to develop specific therapeutic strategies...
  9. ncbi request reprint Interactions of polyphenolic compounds with drug disposition and metabolism
    Francesco Galli
    Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Via del Giochetto 06126, Perugia, Italy
    Curr Drug Metab 8:830-8. 2007
    ..This paper provides an overview of the recent literature on the mechanisms that govern biochemical and molecular responses to polyphenolic compounds relevant to drug metabolism, disposition and therapeutic efficacy...
  10. ncbi request reprint A comparison between the antioxidant and peroxynitrite-scavenging functions of the vitamin E metabolites alpha- and gamma-carboxyethyl-6-hydroxychromans
    Francesco Galli
    Department of Internal Medicine, Section of Applied and Clinical Biochemistry, University of Perugia, Italy
    Int J Vitam Nutr Res 74:362-73. 2004
    ..Further studies are needed to clarify whether CEHC could contribute to the antioxidant network in biological fluids and tissues...
  11. ncbi request reprint Protein damage and inflammation in uraemia and dialysis patients
    Francesco Galli
    Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Via del Giochetto 06126, Perugia, Italy
    Nephrol Dial Transplant 22:v20-36. 2007
    ....
  12. doi request reprint Tocotrienamines and tocopheramines: reactions with radicals and metal ions
    Francesco Galli
    Department of Internal Medicine, Laboratory of Clinical and Nutritional Biochemistry, University of Perugia, Perugia 06126, Italy
    Bioorg Med Chem 19:6483-91. 2011
    ..Possible mechanisms of these reactions were studied...
  13. ncbi request reprint The effect of PMMA-based protein-leaking dialyzers on plasma homocysteine levels
    Francesco Galli
    Department of Internal Medicine, Section of Applied and Clinical Biochemistry, University of Perugia, Italy
    Kidney Int 64:748-55. 2003
    ....
  14. ncbi request reprint Mononuclear leukocyte apoptosis in haemodialysis patients: the role of cell thiols and vitamin E
    Francesco Galli
    Department of Internal Medicine, Section of Applied and Clinical Biochemistry, University of Perugia, Perugia, Italy
    Nephrol Dial Transplant 18:1592-600. 2003
    ..In this study, we investigated the in vitro apoptotic rate and SHi of PBMLs in end-stage renal disease (ESRD) patients on HD or peritoneal dialysis (PD)...
  15. ncbi request reprint gamma-Tocopherol biokinetics and transformation in humans
    Francesco Galli
    Lung Biology, School of Health and Life Sciences, King s College, London, UK
    Free Radic Res 37:1225-33. 2003
    ..The uptake and biotransformation of gamma-tocopherol (gamma-T) in humans is largely unknown. Using a stable isotope method we investigated these aspects of gamma-T biology in healthy volunteers and their response to gamma-T supplementation...
  16. ncbi request reprint The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation
    Francesco Galli
    Section of Applied and Clinical Biochemistry, Department of Internal Medicine, University of Perugia, Via del Giochetto, Perugia 06126, Italy
    Arch Biochem Biophys 423:97-102. 2004
    ....
  17. ncbi request reprint Accumulation of vitamin E metabolites in the blood of renal failure patients
    F Galli
    Section of Applied and Clinical Biochemistry, Department of Internal Medicine, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Clin Nutr 23:205-12. 2004
    ..Carboxyethyl-hydroxychromans (CEHC) are hydrosoluble vitamin E metabolites excreted through the renal filter. In this study we investigated the effect of the kidney damage on the blood levels of CEHC...
  18. ncbi request reprint Oxidatively-modified and glycated proteins as candidate pro-inflammatory toxins in uremia and dialysis patients
    M Piroddi
    Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy
    Amino Acids 32:573-92. 2007
    ..We have also evaluated therapeutic - either pharmacological or dialytic - strategies proposed to alleviate the accumulation of these toxins and to constrain the inflammatory and oxidative burden of ESRD...
  19. ncbi request reprint Vitamin E biochemistry and function: a case study in male rabbit
    C Castellini
    Department of Biologia Vegetale, Biotecnologie Agroambientali e Zootecniche, Borgo XX Giugno 74 06100 Perugia, Italy
    Reprod Domest Anim 42:248-56. 2007
    ..However, the exact dietary intake of vitamin E should be decided according to specific tissue needs for the individual vitamin E forms and the specific saturation markers...
  20. doi request reprint Small intestinal bacterial overgrowth and warfarin dose requirement variability
    Vittorio Giuliano
    Gastrointestinal and Hepatology Section, Department of Clinical and Experimental Medicine, Ospedale S Maria della Misericordia, and Department of Biochemistry Science and Molecular Biotechnologies, University of Perugia, Italy
    Thromb Res 126:12-7. 2010
    ..Larger studies are needed to confirm these preliminary data and to evaluate the effects of SIBO decontamination on warfarin dosage...
  21. doi request reprint Analysis method and characterization of the antioxidant capacity of vitamin E-interactive polysulfone hemodialyzers
    Alessandro Floridi
    Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, 06126 Perugia, Italy
    Acta Biomater 5:2974-82. 2009
    ....
  22. ncbi request reprint Daily haemodialysis improves indices of protein glycation
    Ardesio Floridi
    Department of Internal Medicine, Section of Applied and Clinical Biochemistry, University of Perugia, Italy
    Nephrol Dial Transplant 17:871-8. 2002
    ..In this study, we compare a daily with a standard 3 times/week dialysis rhythm (DHD and SHD, respectively) in correcting some protein glycation indices in end-stage renal disease (ESRD) patients...
  23. ncbi request reprint Focus on cyclo(His-Pro): history and perspectives as antioxidant peptide
    A Minelli
    Dipartimento Medicina Sperimentale Scienze Biochimiche, Sezione Biochimica Cellulare, Universita di Perugia, Via del Giochetto, Perugia, Italy
    Amino Acids 35:283-9. 2008
    ..Future research is underway to better characterize the possible use of this cyclic dipeptide in the therapy of neurodegenerative and metabolic disorders...
  24. doi request reprint Present trends in vitamin E research
    Francesco Galli
    Department of Internal Medicine, Laboratory of Clinical Biochemistry and Nutrition, University of Perugia, Perugia, Italy
    Biofactors 36:33-42. 2010
    ....
  25. pmc Erythrocyte glutathione transferase: a new biomarker for hemodialysis adequacy, overcoming the Kt/V(urea) dogma?
    A Noce
    Department of Internal Medicine, Nephrology and Hypertension Unit, Tor Vergata University, Viale Oxford, Rome, Italy
    Cell Death Dis 3:e377. 2012
    ..e-GST, whose level is stable during the erythrocyte life-span, provides information on the long-term depurative efficacy of dialysis treatments...
  26. ncbi request reprint Vitamin E biotransformation in humans
    Francesco Galli
    Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Italy
    Vitam Horm 76:263-80. 2007
    ..The hypothesis of a transformation-dependent bioactivation of vitamin E represents an intriguing and emerging aspect of research that deserves further investigation...
  27. ncbi request reprint A new method for the liquid chromatography analysis of methylated arginines in biological fluids and tissues by o-phthaldialdehyde postcolumn derivatization
    Carmela Conte
    Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, 06126 Perugia, Italy
    Anal Biochem 338:347-9. 2005
  28. ncbi request reprint Effects of erythropoietin and vitamin E-modified membrane on plasma oxidative stress markers and anemia of hemodialyzed patients
    Mario Usberti
    Servizio di Nefrologia e Dialisi Ospedale di Manerbio, Manerbio, BS, Italy
    Am J Kidney Dis 40:590-9. 2002
    ..Therefore, it is expected that antioxidant therapy might exert a beneficial effect on these parameters...
  29. ncbi request reprint Peroxynitrite-induced oxidation of plasma lipids is enhanced in stable hemodialysis patients
    Barbara Ferraro
    Centre for Hepatology, Royal Free and University College Medical School, London, United Kingdom
    Kidney Int 63:2207-13. 2003
    ....
  30. ncbi request reprint Longitudinal study of apoptosis in chronic uremic patients
    Vincenzo D'Intini
    Department of Nephrology, San Bortolo Hospital, Vicenza, Italy
    Semin Dial 16:467-73. 2003
    ..These results suggest continuous renal purification, such as in continuous ambulatory peritoneal dialysis (CAPD), may have advantages over intermittent therapies in regulating apoptosis and maintaining biologic function and homeostasis...
  31. ncbi request reprint Vitamin E-loaded dialyzer resets PBMC-operated cytokine network in dialysis patients
    Carmelo Libetta
    Unit of Nephrology, Dialysis and Transplantation, IRCCS Policlinico San Matteo and University, Pavia, Italy
    Kidney Int 65:1473-81. 2004
    ..Reactive oxygen species (ROS) activate monocytes; therefore, a hemodialyzer with antioxidant activity would contrast ROS, prevent monocyte activation, reset IL-12 and IL-18 release, and restore Th1/Th2 balance...
  32. ncbi request reprint Vitamin C, vitamin E and immune response
    Francesco Galli
    J Nutr Biochem 16:257; author reply 258. 2005
  33. ncbi request reprint Effects of tocopherols and 2,2'-carboxyethyl hydroxychromans on phorbol-ester-stimulated neutrophils
    Zsuzsa Varga
    First Department of Medicine, Health and Medical Science Centre, University of Debrecen, P O Box 19, H 4012 Debrecen, Hungary
    J Nutr Biochem 19:320-7. 2008
    ..As an original finding, we observed that CEHC metabolites might contribute to regulate PKC activity in these cells. These results may have important implications in the anti-inflammatory and antioxidant role of vitamin E compounds...
  34. ncbi request reprint Effect of the super-flux cellulose triacetate dialyser membrane on the removal of non-protein-bound and protein-bound uraemic solutes
    Rita De Smet
    Renal Division, Department of Internal Medicine, University Hospital Ghent, Gent, Belgium
    Nephrol Dial Transplant 22:2006-12. 2007
    ..Low-flux (LF) HD does not efficiently remove all uraemic compounds. We investigated whether large pore super-flux (SF) cellulose triacetate membranes (CTA) result in a better removal of uraemic solutes...
  35. ncbi request reprint Oxidant and carbonyl stress-related apoptosis in end-stage kidney disease: impact of membrane flux
    Valeria Bordoni
    Department of Nephrology, San Bortolo Hospital, Vicenza, Italy
    Blood Purif 24:149-56. 2006
    ..Plasma carbonyl residues but not AOPPs were significantly lowered. Finally, a significant correlation could be drawn between the extent of plasma-induced proapoptotic activity and both plasma carbonyl and AOPP levels...
  36. ncbi request reprint Antiproliferative effects of tocopherols (vitamin E) on murine glioma C6 cells: homologue-specific control of PKC/ERK and cyclin signaling
    Michele Betti
    Institute of Physiological Sciences, University of Urbino Carlo Bo, Urbino, Italy
    Free Radic Biol Med 41:464-72. 2006
    ..In conclusion, within TOCs the gamma form exerts the most potent and specific control of cell cycle progression in C6 cells (cytostatic effect). This suggests a chemopreventive role of this form of vitamin E in gliomas...
  37. pmc Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer disease
    Miranda L Bader Lange
    Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Ageing, University of Kentucky, Lexington, KY 40506 0055, USA
    Neurobiol Dis 29:456-64. 2008
    ..This study contributes to a model of apoptosis-specific oxidation of phospholipids consistent with the notion that PtdSer exposure is required for apoptotic-cell death...