Research Topics
| F GalliSummaryAffiliation: University of Perugia Country: Italy Publications
| Collaborators
|
Detail Information
Publications
Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cellsCarmela Conte
University of Perugia, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, Via del Giochetto, 06126 Perugia, Italy
Ann N Y Acad Sci 1031:391-4. 2004..These early findings may suggest that the transformation of vitamin E to CEHC is mostly a detoxification mechanism useful to maintain the malignant properties of prostate cancer cells...- Membrane rafts and redox therapies in cancer: a commentary on "Radioresistance of human carcinoma cells is correlated to a defect in raft membrane clustering"Francesco Galli
Section of Applied Biochemistry and Nutritional Sciences, Department of Internal Medicine, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
Free Radic Biol Med 43:678-80. 2007 
Oxidative stress and antioxidant therapy in cystic fibrosisFrancesco Galli
Department of Internal Medicine, Laboratory of Clinical Biochemistry and Nutrition, University of Perugia, Italy
Biochim Biophys Acta 1822:690-713. 2012..This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease...- Gas chromatography mass spectrometry analysis of carboxyethyl-hydroxychroman metabolites of alpha- and gamma-tocopherol in human plasmaFrancesco Galli
Dept of Internal Medicine, Section of Applied and Clinical Biochemistry, University of Perugia, Italy corrected
Free Radic Biol Med 32:333-40. 2002..This GC/MS method provides a versatile and accurate mean for assessing carboxyethyl-hydroxychroman metabolites of vitamin E in plasma... - Glycoxidation and inflammatory markers in patients on treatment with PMMA-based protein-leaking dialyzersFrancesco Galli
Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy
Kidney Int 67:750-9. 2005..The elimination of these and other large solutes by protein-leaking dialyzers (PLD) might help to correct the inflammatory status of maintenance hemodialysis (HD) patients... - Do statins cause myopathy by lowering vitamin E levels?Francesco Galli
Faculty of Pharmacy, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
Med Hypotheses 74:707-9. 2010..This hypothesis that needs to be further investigated, could suggest the need for precautionary measures during lipid lowering therapy, which include timely diagnosis and active prevention of vitamin E deficiency... - Vitamin E in uremia and dialysis patientsFrancesco Galli
University of Perugia, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, Via del Giochetto, 06126 Perugia, Italy
Ann N Y Acad Sci 1031:348-51. 2004..Although further studies are needed to confirm the clinical relevance of vitamin E therapy in HD, these findings might lead to recommending a higher vitamin E intake in these patients... - Oxidative stress and reactive oxygen speciesFrancesco Galli
Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy
Contrib Nephrol 149:240-60. 2005..These technological advancements and the huge information available in literature represent in our time a challenge to further understand the clinical meaning of oxidative stress and to develop specific therapeutic strategies... - Interactions of polyphenolic compounds with drug disposition and metabolismFrancesco Galli
Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Via del Giochetto 06126, Perugia, Italy
Curr Drug Metab 8:830-8. 2007..This paper provides an overview of the recent literature on the mechanisms that govern biochemical and molecular responses to polyphenolic compounds relevant to drug metabolism, disposition and therapeutic efficacy... - A comparison between the antioxidant and peroxynitrite-scavenging functions of the vitamin E metabolites alpha- and gamma-carboxyethyl-6-hydroxychromansFrancesco Galli
Department of Internal Medicine, Section of Applied and Clinical Biochemistry, University of Perugia, Italy
Int J Vitam Nutr Res 74:362-73. 2004..Further studies are needed to clarify whether CEHC could contribute to the antioxidant network in biological fluids and tissues... - Protein damage and inflammation in uraemia and dialysis patientsFrancesco Galli
Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Via del Giochetto 06126, Perugia, Italy
Nephrol Dial Transplant 22:v20-36. 2007.... - Tocotrienamines and tocopheramines: reactions with radicals and metal ionsFrancesco Galli
Department of Internal Medicine, Laboratory of Clinical and Nutritional Biochemistry, University of Perugia, Perugia 06126, Italy
Bioorg Med Chem 19:6483-91. 2011..Possible mechanisms of these reactions were studied... - The effect of PMMA-based protein-leaking dialyzers on plasma homocysteine levelsFrancesco Galli
Department of Internal Medicine, Section of Applied and Clinical Biochemistry, University of Perugia, Italy
Kidney Int 64:748-55. 2003.... - Mononuclear leukocyte apoptosis in haemodialysis patients: the role of cell thiols and vitamin EFrancesco Galli
Department of Internal Medicine, Section of Applied and Clinical Biochemistry, University of Perugia, Perugia, Italy
Nephrol Dial Transplant 18:1592-600. 2003..In this study, we investigated the in vitro apoptotic rate and SHi of PBMLs in end-stage renal disease (ESRD) patients on HD or peritoneal dialysis (PD)... - gamma-Tocopherol biokinetics and transformation in humansFrancesco Galli
Lung Biology, School of Health and Life Sciences, King s College, London, UK
Free Radic Res 37:1225-33. 2003..The uptake and biotransformation of gamma-tocopherol (gamma-T) in humans is largely unknown. Using a stable isotope method we investigated these aspects of gamma-T biology in healthy volunteers and their response to gamma-T supplementation... - The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferationFrancesco Galli
Section of Applied and Clinical Biochemistry, Department of Internal Medicine, University of Perugia, Via del Giochetto, Perugia 06126, Italy
Arch Biochem Biophys 423:97-102. 2004.... - Accumulation of vitamin E metabolites in the blood of renal failure patientsF Galli
Section of Applied and Clinical Biochemistry, Department of Internal Medicine, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
Clin Nutr 23:205-12. 2004..Carboxyethyl-hydroxychromans (CEHC) are hydrosoluble vitamin E metabolites excreted through the renal filter. In this study we investigated the effect of the kidney damage on the blood levels of CEHC... - Oxidatively-modified and glycated proteins as candidate pro-inflammatory toxins in uremia and dialysis patientsM Piroddi
Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Perugia, Italy
Amino Acids 32:573-92. 2007..We have also evaluated therapeutic - either pharmacological or dialytic - strategies proposed to alleviate the accumulation of these toxins and to constrain the inflammatory and oxidative burden of ESRD... - Vitamin E biochemistry and function: a case study in male rabbitC Castellini
Department of Biologia Vegetale, Biotecnologie Agroambientali e Zootecniche, Borgo XX Giugno 74 06100 Perugia, Italy
Reprod Domest Anim 42:248-56. 2007..However, the exact dietary intake of vitamin E should be decided according to specific tissue needs for the individual vitamin E forms and the specific saturation markers... - Small intestinal bacterial overgrowth and warfarin dose requirement variabilityVittorio Giuliano
Gastrointestinal and Hepatology Section, Department of Clinical and Experimental Medicine, Ospedale S Maria della Misericordia, and Department of Biochemistry Science and Molecular Biotechnologies, University of Perugia, Italy
Thromb Res 126:12-7. 2010..Larger studies are needed to confirm these preliminary data and to evaluate the effects of SIBO decontamination on warfarin dosage... - Analysis method and characterization of the antioxidant capacity of vitamin E-interactive polysulfone hemodialyzersAlessandro Floridi
Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, 06126 Perugia, Italy
Acta Biomater 5:2974-82. 2009.... - Daily haemodialysis improves indices of protein glycationArdesio Floridi
Department of Internal Medicine, Section of Applied and Clinical Biochemistry, University of Perugia, Italy
Nephrol Dial Transplant 17:871-8. 2002..Therefore, DHD can provide a better control of AGE produced in ESRD. This could result in a lower incidence of long-term effects of AGE accumulation in HD... - Focus on cyclo(His-Pro): history and perspectives as antioxidant peptideA Minelli
Dipartimento Medicina Sperimentale Scienze Biochimiche, Sezione Biochimica Cellulare, Universita di Perugia, Via del Giochetto, Perugia, Italy
Amino Acids 35:283-9. 2008..Future research is underway to better characterize the possible use of this cyclic dipeptide in the therapy of neurodegenerative and metabolic disorders... - Present trends in vitamin E researchFrancesco Galli
Department of Internal Medicine, Laboratory of Clinical Biochemistry and Nutrition, University of Perugia, Perugia, Italy
Biofactors 36:33-42. 2010.... 
Erythrocyte glutathione transferase: a new biomarker for hemodialysis adequacy, overcoming the Kt/V(urea) dogma?A Noce
Department of Internal Medicine, Nephrology and Hypertension Unit, Tor Vergata University, Viale Oxford, Rome, Italy
Cell Death Dis 3:e377. 2012..e-GST, whose level is stable during the erythrocyte life-span, provides information on the long-term depurative efficacy of dialysis treatments...- Vitamin E biotransformation in humansFrancesco Galli
Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, Italy
Vitam Horm 76:263-80. 2007..The hypothesis of a transformation-dependent bioactivation of vitamin E represents an intriguing and emerging aspect of research that deserves further investigation... - A new method for the liquid chromatography analysis of methylated arginines in biological fluids and tissues by o-phthaldialdehyde postcolumn derivatizationCarmela Conte
Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, University of Perugia, 06126 Perugia, Italy
Anal Biochem 338:347-9. 2005 - Effects of erythropoietin and vitamin E-modified membrane on plasma oxidative stress markers and anemia of hemodialyzed patientsMario Usberti
Servizio di Nefrologia e Dialisi Ospedale di Manerbio, Manerbio, BS, Italy
Am J Kidney Dis 40:590-9. 2002..Therefore, it is expected that antioxidant therapy might exert a beneficial effect on these parameters... - Peroxynitrite-induced oxidation of plasma lipids is enhanced in stable hemodialysis patientsBarbara Ferraro
Centre for Hepatology, Royal Free and University College Medical School, London, United Kingdom
Kidney Int 63:2207-13. 2003.... - Longitudinal study of apoptosis in chronic uremic patientsValeria Bordoni
Department of Nephrology, San Bortolo Hospital, Vicenza, Italy
Semin Dial 16:467-73. 2003..These results suggest continuous renal purification, such as in continuous ambulatory peritoneal dialysis (CAPD), may have advantages over intermittent therapies in regulating apoptosis and maintaining biologic function and homeostasis... - Vitamin E-loaded dialyzer resets PBMC-operated cytokine network in dialysis patientsCarmelo Libetta
Unit of Nephrology, Dialysis and Transplantation, IRCCS Policlinico San Matteo and University, Pavia, Italy
Kidney Int 65:1473-81. 2004..Reactive oxygen species (ROS) activate monocytes; therefore, a hemodialyzer with antioxidant activity would contrast ROS, prevent monocyte activation, reset IL-12 and IL-18 release, and restore Th1/Th2 balance... - Vitamin C, vitamin E and immune responseFrancesco Galli
J Nutr Biochem 16:257; author reply 258. 2005 - Effects of tocopherols and 2,2'-carboxyethyl hydroxychromans on phorbol-ester-stimulated neutrophilsZsuzsa Varga
First Department of Medicine, Health and Medical Science Centre, University of Debrecen, P O Box 19, H 4012 Debrecen, Hungary
J Nutr Biochem 19:320-7. 2008..As an original finding, we observed that CEHC metabolites might contribute to regulate PKC activity in these cells. These results may have important implications in the anti-inflammatory and antioxidant role of vitamin E compounds... - Effect of the super-flux cellulose triacetate dialyser membrane on the removal of non-protein-bound and protein-bound uraemic solutesRita De Smet
Renal Division, Department of Internal Medicine, University Hospital Ghent, Gent, Belgium
Nephrol Dial Transplant 22:2006-12. 2007..Low-flux (LF) HD does not efficiently remove all uraemic compounds. We investigated whether large pore super-flux (SF) cellulose triacetate membranes (CTA) result in a better removal of uraemic solutes... - Oxidant and carbonyl stress-related apoptosis in end-stage kidney disease: impact of membrane fluxValeria Bordoni
Department of Nephrology, San Bortolo Hospital, Vicenza, Italy
Blood Purif 24:149-56. 2006..Plasma carbonyl residues but not AOPPs were significantly lowered. Finally, a significant correlation could be drawn between the extent of plasma-induced proapoptotic activity and both plasma carbonyl and AOPP levels... - Antiproliferative effects of tocopherols (vitamin E) on murine glioma C6 cells: homologue-specific control of PKC/ERK and cyclin signalingMichele Betti
Institute of Physiological Sciences, University of Urbino Carlo Bo, Urbino, Italy
Free Radic Biol Med 41:464-72. 2006..In conclusion, within TOCs the gamma form exerts the most potent and specific control of cell cycle progression in C6 cells (cytostatic effect). This suggests a chemopreventive role of this form of vitamin E in gliomas... - Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer diseaseMiranda L Bader Lange
Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Ageing, University of Kentucky, Lexington, KY 40506 0055, USA
Neurobiol Dis 29:456-64. 2008..This study contributes to a model of apoptosis-specific oxidation of phospholipids consistent with the notion that PtdSer exposure is required for apoptotic-cell death...