Daniela Galimberti

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Arch Neurol 63:538-43. 2006
  2. pmc Genetics of frontotemporal lobar degeneration
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan Milan, Italy
    Front Neurol 3:52. 2012
  3. ncbi The C9ORF72 hexanucleotide repeat expansion is a rare cause of schizophrenia
    Daniela Galimberti
    Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy Electronic address
    Neurobiol Aging 35:1214.e7-1214.e10. 2014
  4. doi Immunotherapy against amyloid pathology in Alzheimer's disease
    Daniela Galimberti
    Neurology Unit, Dept of Pathophysiology and Transplantation, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy Electronic address
    J Neurol Sci 333:50-4. 2013
  5. doi Autosomal dominant frontotemporal lobar degeneration due to the C9ORF72 hexanucleotide repeat expansion: late-onset psychotic clinical presentation
    Daniela Galimberti
    Neurology Unit, Department of Phatophysiology and Transplantation, University of Milan, Fondazione Cà Granda, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Policlinico, Italy
    Biol Psychiatry 74:384-91. 2013
  6. doi Progress in Alzheimer's disease research in the last year
    Daniela Galimberti
    Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Via F Sforza 35, 20122 Milan, Italy
    J Neurol 260:1936-41. 2013
  7. doi Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration
    Daniela Galimberti
    Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurol Sci 34:899-903. 2013
  8. pmc Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia
    Daniela Galimberti
    Department of Neurological Sciences, University of Milan, IRCCS Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    PLoS ONE 7:e32164. 2012
  9. doi Progress in multiple sclerosis research in the last year
    Daniela Galimberti
    University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Neurol 259:1497-501. 2012
  10. doi Clinical phenotypes and genetic biomarkers of FTLD
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy
    J Neural Transm 119:851-60. 2012

Detail Information

Publications108 found, 100 shown here

  1. ncbi Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Arch Neurol 63:538-43. 2006
    ....
  2. pmc Genetics of frontotemporal lobar degeneration
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan Milan, Italy
    Front Neurol 3:52. 2012
    ..In this review, current knowledge about mutations at the basis of familial FTLD will be described, together with genetic risk factors influencing the susceptibility to FTLD...
  3. ncbi The C9ORF72 hexanucleotide repeat expansion is a rare cause of schizophrenia
    Daniela Galimberti
    Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy Electronic address
    Neurobiol Aging 35:1214.e7-1214.e10. 2014
    ..The repeat expansion in the C9ORF72 gene is a rare, but possible, cause of schizophrenic spectrum disorders. We cannot rule out however whether the number of repeats influence the phenotype. ..
  4. doi Immunotherapy against amyloid pathology in Alzheimer's disease
    Daniela Galimberti
    Neurology Unit, Dept of Pathophysiology and Transplantation, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy Electronic address
    J Neurol Sci 333:50-4. 2013
    ..In this article, current knowledge about concluded and ongoing clinical trials with both vaccination with different antigens and passive immunization will be reviewed and discussed. ..
  5. doi Autosomal dominant frontotemporal lobar degeneration due to the C9ORF72 hexanucleotide repeat expansion: late-onset psychotic clinical presentation
    Daniela Galimberti
    Neurology Unit, Department of Phatophysiology and Transplantation, University of Milan, Fondazione Cà Granda, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Policlinico, Italy
    Biol Psychiatry 74:384-91. 2013
    ..Atypical presentations have been described, particularly psychosis...
  6. doi Progress in Alzheimer's disease research in the last year
    Daniela Galimberti
    Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Via F Sforza 35, 20122 Milan, Italy
    J Neurol 260:1936-41. 2013
    ..Herein, we summarize and discuss the main articles describing novel findings in AD published over the last year, including clinical, therapeutic, and research issues...
  7. doi Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration
    Daniela Galimberti
    Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurol Sci 34:899-903. 2013
    ..05). GRN promoter methylation was not correlated with age. In conclusion, the degree of methylation of the GRN promoter is increased in patients with FTLD as compared with controls, likely leading to a decreased expression of GRN...
  8. pmc Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia
    Daniela Galimberti
    Department of Neurological Sciences, University of Milan, IRCCS Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    PLoS ONE 7:e32164. 2012
    ..Nevertheless, a larger replication analysis would be needed to confirm these preliminary results...
  9. doi Progress in multiple sclerosis research in the last year
    Daniela Galimberti
    University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Neurol 259:1497-501. 2012
    ..Herein, we summarize the main articles describing novel findings in multiple sclerosis published in the Journal of Neurology over the last year, including clinical, therapeutic and research issues...
  10. doi Clinical phenotypes and genetic biomarkers of FTLD
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy
    J Neural Transm 119:851-60. 2012
    ..In this review, new criteria, including MRI, cerebrospinal fluid and genetic biomarkers, will be presented and discussed...
  11. ncbi Progress in Alzheimer's disease
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, University of Milan, Via F Sforza 35, 20122, Milan, Italy
    J Neurol 259:201-11. 2012
    ..In addition, treatment options will be discussed, with emphasis on new disease-modifying compounds and future trial design suitable to test these drugs in an early phase of the disease...
  12. pmc Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients
    Paola Bossù
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Neuroinflammation 8:65. 2011
    ..Thus, our findings point to IL-6 as a possible specific mediator and a potential therapeutic target in this monogenic disease, suggesting that an enhanced inflammatory response might be indeed involved in its progression...
  13. ncbi Chemokine network in multiple sclerosis: role in pathogenesis and targeting for future treatments
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center and Center of Excellence for Neurodegenerative Diseases, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy
    Expert Rev Neurother 4:439-53. 2004
    ....
  14. ncbi Intrathecal chemokine levels in Alzheimer disease and frontotemporal lobar degeneration
    D Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurology 66:146-7. 2006
  15. doi GSK3β genetic variability in patients with Multiple Sclerosis
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurosci Lett 497:46-8. 2011
    ..7%, P=0.01; OR: 1.72, 95%CI: 1.13-2.61). GSK3β rs334558 is a susceptibility factor for MS. As it is located in the promoter region, a possible explanatory mechanism could be an influence of the variant on the gene transcription rate...
  16. ncbi MDC/CCL22 intrathecal levels in patients with multiple sclerosis
    D Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Mult Scler 14:547-9. 2008
    ..034 and 0.018, respectively). Therefore, MDC/CCL22 is likely to play a role in the development of MS in females only, possibly influencing the intracerebral recruitment of Th2 cells, which produce anti-inflammatory cytokines...
  17. ncbi Intrathecal levels of IL-6, IL-11 and LIF in Alzheimer's disease and frontotemporal lobar degeneration
    Daniela Galimberti
    Dept of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    J Neurol 255:539-44. 2008
    ....
  18. ncbi CXCL10 haplotypes and multiple sclerosis: association and correlation with clinical course
    D Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Eur J Neurol 14:162-7. 2007
    ..08). Therefore, the GGTT haplotype of the CXCL10 gene is not a susceptibility factor for the development of MS, but is probably to influence the course of MS, possibly contributing to slow down the progression of the disease...
  19. ncbi Association of a NOS1 promoter repeat with Alzheimer's disease
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Ospedale Maggiore Policlinico IRCCS, Milan, Italy
    Neurobiol Aging 29:1359-65. 2008
    ..83). Therefore, short alleles of the NOS1 exon 1f-VNTR are likely to be susceptibility factors for AD, and interact with the epsilon 4 allele to markedly increase the AD risk...
  20. ncbi Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122, Milan, Italy
    J Neurol Sci 267:86-90. 2008
    ..06-0.50), whereas no significant differences were observed in females. Therefore, the presence of the AT haplotype in chromosome 16 chemokine cluster is likely to confer a decreased risk of developing MS, particularly in males...
  21. ncbi Alzheimer's disease: from pathogenesis to disease-modifying approaches
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy
    CNS Neurol Disord Drug Targets 10:163-74. 2011
    ....
  22. ncbi Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer's disease
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Neurobiol Aging 27:1763-8. 2006
    ..Nevertheless, as MCP-1 is likely to play a role in several pathologies with an inflammatory component, a possible usefulness as an early AD biomarker would be possible only in combination with other molecules...
  23. ncbi Inflammation in neurodegenerative disorders: friend or foe?
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Ospedale Maggiore Policlinico IRCCS, Via F Sforza 35, 20122, Milan, Italy
    Curr Aging Sci 1:30-41. 2008
    ..With these premises, genetic studies recently carried out will be described and discussed in detail...
  24. ncbi GRN variability contributes to sporadic frontotemporal lobar degeneration
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 19:171-7. 2010
    ..This SNP is likely located in a regulatory region, thus an effect on GRN mRNA levels may be of mechanistic importance...
  25. ncbi Inflammation and oxidative damage in Alzheimer's disease: friend or foe?
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy
    Front Biosci (Schol Ed) 3:252-66. 2011
    ..Gene polymorphisms in crucial molecules, including cytokines, chemokines and molecules related to oxidative stress, may act as susceptibility factors, or may operate as regulatory factors, modulating the severity of pathogenic processes...
  26. ncbi Treatment of Alzheimer's disease: symptomatic and disease-modifying approaches
    Daniela Galimberti
    Dept of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy
    Curr Aging Sci 3:46-56. 2010
    ....
  27. doi MCP-1 A-2518G polymorphism: effect on susceptibility for frontotemporal lobar degeneration and on cerebrospinal fluid MCP-1 levels
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 17:125-33. 2009
    ..21 +/- 44.57 versus 395.87 +/- 21.92 pg/ml, P = 0.045). The MCP-1 A-2518G SNP acts as protective factor for sporadic FTLD, possibly by influencing MCP-1 production...
  28. doi Candidate gene analysis of semaphorins in patients with Alzheimer's disease
    Chiara Villa
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    Neurol Sci 31:169-73. 2010
    ..This high degree of conservation of Sema3A suggests a very important role for this protein. However, neither Sema3A nor Sema4D likely influence the susceptibility to AD...
  29. ncbi Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis
    Diego Scalabrini
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurosci Lett 425:173-6. 2007
    ..However, the frequency of the C/C genotype of rs1049544 was decreased in male patients, possibly conferring a lower risk of developing MS in male population. Further studies are needed to clarify this issue...
  30. doi Role of OLR1 and its regulating hsa-miR369-3p in Alzheimer's disease: genetics and expression analysis
    Maria Serpente
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 26:787-93. 2011
    ..Nevertheless, the limited power of the study requires further investigations with a larger sample size...
  31. ncbi Is M129V of PRNP gene associated with Alzheimer's disease? A case-control study and a meta-analysis
    Roberto Del Bo
    Dino Ferrari Centre, Department of Neurological Sciences, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Padiglione Ponti, Milano, Italy
    Neurobiol Aging 27:770.e1-770.e5. 2006
    ..We also observed that MM genotype and M allele represent a risk factor for AD, independently from the ethnic background, providing a significant but modest association between this polymorphism and AD...
  32. ncbi MCP-1 in Alzheimer's disease patients: A-2518G polymorphism and serum levels
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Neurobiol Aging 25:1169-73. 2004
    ..The A-2518G polymorphism in MCP-1 gene does not seem to be a risk factor for the development of AD, but its presence correlates with higher levels of serum MCP-1, which can contribute to increase the inflammatory process occurring in AD...
  33. doi Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic Mild Cognitive Impairment converted to Alzheimer's disease
    Miryam Carecchio
    Department of Neurological Sciences, Dino Ferrari Centre, IRCCS Fondazione Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
    J Neurol Sci 287:291-3. 2009
    ..We thus encourage the inclusion of this non-invasive and easy test in clinical practice...
  34. ncbi CCR2-64I polymorphism and CCR5Delta32 deletion in patients with Alzheimer's disease
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    J Neurol Sci 225:79-83. 2004
    ..Stratifying by the presence of ApoE varepsilon4 allele, gender or age at onset, no differences in either allele frequencies were observed...
  35. ncbi P-selectin glycoprotein ligand-1 variable number of tandem repeats (VNTR) polymorphism in patients with multiple sclerosis
    Diego Scalabrini
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122 Milan, Italy
    Neurosci Lett 388:149-52. 2005
    ..As this allele has been demonstrated to have a very low efficiency in mediating lymphocyte binding to brain endothelium during attacks, its high frequency in PP-MS could be related to the absence of exacerbations in such patients...
  36. ncbi Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with Alzheimer's disease
    Chiara Villa
    Neurology Unit, Department of Pathophysiology and Transplantation Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 35:487-94. 2013
    ..Moreover, Sp1 rs176951056 T allele is likely a protective factor in the male population...
  37. doi Role of hnRNP-A1 and miR-590-3p in neuronal death: genetics and expression analysis in patients with Alzheimer disease and frontotemporal lobar degeneration
    Chiara Villa
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Rejuvenation Res 14:275-81. 2011
    ..0237). According to these findings, hnRNP-A1 and its transcription regulatory factor miR-590-3p are disregulated in patients with AD, and the hnRNP-A1 rs7967622 C/C genotype is likely a risk factor for FTLD in male populations...
  38. ncbi Influence of the Glu298Asp polymorphism of NOS3 on age at onset and homocysteine levels in AD patients
    Ilaria Guidi
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Neurobiol Aging 26:789-94. 2005
    ..Besides, a contribution of the Glu/Glu genotype in increasing tHcy levels has been observed...
  39. ncbi Candidate gene analysis of IP-10 gene in patients with Alzheimer's disease
    Eliana Venturelli
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Italy
    Neurosci Lett 404:217-21. 2006
    ..However, a novel rare polymorphism has been identified, which could exert a role in AD susceptibility. Thus, further studies on larger populations are needed before confidently excluding IP-10 as a susceptibility gene for AD...
  40. ncbi Novel evidence of phenotypical variability in the hexanucleotide repeat expansion in chromosome 9
    Chiara Cerami
    Neurorehabilitation Unit, Department of Clinical Neurosciences, San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy
    J Alzheimers Dis 35:455-62. 2013
    ..The present findings confirm the importance of screening for the hexanucleotide repeat expansion in chromosome 9 in the case not only of familial, but also of sporadic FTD, and in the presence of atypical cognitive disorders...
  41. ncbi Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease
    Ilaria Guidi
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Neurobiol Aging 27:262-9. 2006
    ..ROS levels appear to be correlated with age rather than with a specific dementing disorder, thus leading to the hypothesis that oxidative imbalance observed in AD could be due to a decreased TAC...
  42. doi A novel MAPT mutation associated with the clinical phenotype of progressive nonfluent aphasia
    Chiara Villa
    Department of Neurological Sciences, University of Milan, IRCCS Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 26:19-26. 2011
    ..The amino acid change likely compromises the ability of tau to properly regulate the dynamic behavior of microtubules...
  43. doi Early onset behavioral variant frontotemporal dementia due to the C9ORF72 hexanucleotide repeat expansion: psychiatric clinical presentations
    Andrea Arighi
    Department of Neurological Sciences, University of Milan, Dino Ferrari Center, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy
    J Alzheimers Dis 31:447-52. 2012
    ..The description of these cases underlines that the hexanucleotide repeat expansion in chromosome 9 could be associated with early onset psychiatric presentations...
  44. doi BAG1 is a protective factor for sporadic frontotemporal lobar degeneration but not for Alzheimer's disease
    Eliana Venturelli
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 23:701-7. 2011
    ..BAG-1 rs706118 SNP likely acts as protective factor for sporadic FTLD, but not for AD, suggesting its specific role in a pathogenic event in FTLD. Nevertheless, a replication study would be needed to confirm these preliminary results...
  45. ncbi SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Italy
    Neurosci Lett 394:92-6. 2006
    ..Therefore, none of the SNPs investigated is associated with MS, although this analysis does not conclusively exclude SELPLG and SELP as genetic risk factors for MS as much variation remains untested...
  46. doi Is KIF24 a genetic risk factor for Frontotemporal Lobar Degeneration?
    Eliana Venturelli
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurosci Lett 482:240-4. 2010
    ..05). The KIF24 rs17350674 polymorphism likely acts as a risk factor for sporadic FTLD, but a replication study would be needed to confirm these preliminary findings...
  47. ncbi The T-786C NOS3 polymorphism in Alzheimer's disease: association and influence on gene expression
    Eliana Venturelli
    Department of Neurological Sciences, Dino Ferrari Center and CEND, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurosci Lett 382:300-3. 2005
    ....
  48. doi Phenotypic heterogeneity of the GRN Asp22fs mutation in a large Italian kindred
    Anna M Pietroboni
    Department of Neurological Sciences, University of Milan, IRCCS Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 24:253-9. 2011
    ....
  49. doi Expression and genetic analysis of miRNAs involved in CD4+ cell activation in patients with multiple sclerosis
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurosci Lett 504:9-12. 2011
    ..miRNA dysregulation may contribute to the pathogenesis of MS and highlights the possibility to define different disease entities with specific miRNAs profile...
  50. ncbi Absence of TREM2 polymorphisms in patients with Alzheimer's disease and Frontotemporal Lobar Degeneration
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    Neurosci Lett 411:133-7. 2007
    ..Further studies, including a functional analysis, are certainly required to clarify the role of TREM2 in neurodegenerative processes...
  51. doi The serotonin transporter promoter polymorphic region is not a risk factor for Alzheimer's disease related behavioral disturbances
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Alzheimers Dis 18:125-30. 2009
    ..We conclude that 5-HTTLPR and rs25531 are not major genetic modulators of BPSD development in AD...
  52. doi Corneal involvement in rheumatoid arthritis: an in vivo confocal study
    Edoardo Villani
    Clinica Oculistica Università degli Studi di Milano, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, IRCCS Istituto Ricerca e Cura a Carattere Scientifico, Milan, Italy
    Invest Ophthalmol Vis Sci 49:560-4. 2008
    ..To analyze the in vivo morphology of corneal cells and nerves in patients with rheumatoid arthritis (RA), with or without secondary Sjögren's syndrome (SSII), and to investigate the correlations between corneal alterations and RA activity...
  53. ncbi Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis
    Chiara Fenoglio
    Department of Pathophysiology and Transplantation Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
    Mult Scler 19:1938-42. 2013
    ..Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers. ..
  54. ncbi The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease in two Caucasian case-control cohorts
    Letizia Polito
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy Golgi Cenci Foundation, Abbiategrasso, Italy
    Alzheimers Dement 9:392-9. 2013
    ..This study investigated whether genetic variants in two members of the sirtuin family, SIRT2 and SIRT3, affected AD susceptibility...
  55. doi From genotype to phenotype: two cases of genetic frontotemporal lobar degeneration with premorbid bipolar disorder
    Chiara Cerami
    Neurorehabilitation Unit, Department of Clinical Neurosciences, Vita Salute University and San Raffaele Scientific Institute, Milan, Italy
    J Alzheimers Dis 27:791-7. 2011
    ..11019_11022delCACT mutation in Northern Italy. On this basis, we recommend to consider the presence of this mutation as a possible cause of the disease, particularly in patients with premorbid psychiatric symptoms...
  56. ncbi Genetics and expression analysis of the specificity protein 4 gene (SP4) in patients with Alzheimer's disease and frontotemporal lobar degeneration
    Chiara Villa
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy
    J Alzheimers Dis 31:537-42. 2012
    ..However, Sp4 mRNA levels are upregulated in patients, possibly resulting in an aberrant expression of downstream target genes involved in the pathogenesis of both diseases...
  57. ncbi E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122, Milan, Italy
    J Neuroimmunol 165:201-5. 2005
    ..The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS...
  58. pmc Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 18:603-12. 2009
    ..14, CC = 1.22 +/- 0.23; P = 0.013). These data argue against a direct role of GRN as a susceptibility factor for sporadic AD but support a role of GRN as a disease-modifying gene, possibly contributing to the failure of neuronal survival...
  59. ncbi Role of VEGF gene variability in longevity: a lesson from the Italian population
    Roberto Del Bo
    Department of Neurological Sciences, Dino Ferrari Centre, University of Milan, IRCCS Foundation Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena, Padiglione Ponti, Milano, Italy
    Neurobiol Aging 29:1917-22. 2008
    ..These results suggest that VEGF gene variability can be inserted among the genetic factors influencing the lifespan...
  60. ncbi Novel missense progranulin gene mutation associated with the semantic variant of primary progressive aphasia
    Chiara Cerami
    Neurorehabilitation Unit, Department of Clinical Neurosciences, San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Via Olgettina 60, Milan, Italy
    J Alzheimers Dis 36:415-20. 2013
    ..This case confirms that GRN represents one of the most frequent FTLD genetic causes, suggesting that a screening is indicated in the case of svPPA presentation. ..
  61. pmc Cerebrospinal fluid progranulin levels in patients with different multiple sclerosis subtypes
    Milena De Riz
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122 Milan, Italy
    Neurosci Lett 469:234-6. 2010
    ..A positive correlation between progranulin CSF levels and age was observed in patients (rho=0.29, P=0.03). According to these data, progranulin does not likely play a major role in the pathogenesis of MS...
  62. pmc No major progranulin genetic variability contribution to disease etiopathogenesis in an ALS Italian cohort
    Roberto Del Bo
    Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, IRCCS Foundation Ospedale Maggiore Policlinico Mangiagalli and Regina Elena, Milan, Italy
    Neurobiol Aging 32:1157-8. 2011
    ..The p.S120Y variant may characterize rare patients with SALS, although its pathogenetic mechanism remains to be elucidated...
  63. ncbi Serotonin transporter gene polymorphic element 5-HTTLPR increases the risk of sporadic Parkinson's disease in Italy
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur Neurol 62:120-3. 2009
    ..5], p = 0.002) was found. The rs25531 and the haplotype 5-HTTLPR/rs25531 did not associate with risk of PD. Our data indicate that the 5-HTTLPR polymorphic element within the SLC6A4 promoter may govern the genetic risk of PD in Italians...
  64. doi GRN Thr272fs clinical heterogeneity: a case with atypical late onset presenting with a dementia with Lewy bodies phenotype
    Beatrice Arosio
    Geriatric Unit, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 35:669-74. 2013
    ..A major contributing factor to the diagnosis was the testing of plasmatic progranulin levels (extremely low), which prompted us to sequence GRN...
  65. doi Pharmacogenomics in Alzheimer's disease: a genome-wide association study of response to cholinesterase inhibitors
    Filippo Martinelli-Boneschi
    San Raffaele Scientific Institute, Division of Neuroscience, Laboratory of Genetics of Complex Neurological Disorders, Institute of Experimental Neurology INSPE, Milan, Italy
    Neurobiol Aging 34:1711.e7-13. 2013
    ..Despite its limitations, this project paves the way for the application of personalized medicine in AD patients and for collaborative efforts in this field...
  66. ncbi Inclusion body myopathy and frontotemporal dementia caused by a novel VCP mutation
    Anna Bersano
    Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, IRCCS Foundation Ospedale Maggiore Policlinico Mangiagalli and Regina Elena, Via F Sforza 35, 20122 Milan, Italy
    Neurobiol Aging 30:752-8. 2009
    ..These findings suggest VCP gene investigation even in apparently sporadic cases...
  67. ncbi Candidate gene analysis of selectin cluster in patients with multiple sclerosis
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Neurol 256:832-3. 2009
    ....
  68. ncbi Vascular endothelial growth factor gene variability is associated with increased risk for AD
    Roberto Del Bo
    Department of Neurological Sciences, Dino Ferrari Centre and Centre of Excellence on Neurodegenerative Diseases, University of Milan, I R C C S Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Ann Neurol 57:373-80. 2005
    ..These findings suggest that polymorphisms within the promoter region of the VEGF gene confer greater risk for AD, probably by reducing its neuroprotective effect, and confirm the biological role of VEGF in neurodegenerative processes...
  69. doi Founder effect and estimation of the age of the Progranulin Thr272fs mutation in 14 Italian pedigrees with frontotemporal lobar degeneration
    Barbara Borroni
    The Centre for Ageing Brain and Neurodegenerative Disorders, Neurology Unit, University of Brescia, Brescia, Italy
    Neurobiol Aging 32:555.e1-8. 2011
    ....
  70. doi Replication study to confirm the role of CYP2D6 polymorphism rs1080985 on donepezil efficacy in Alzheimer's disease patients
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Alzheimers Dis 30:745-9. 2012
    ..74 [1.01-3.00], p = 0.04). Rs1080985 might be useful as predictor of poor response to short-term donepezil treatment...
  71. pmc Expression and Genetic Analysis of MicroRNAs Involved in Multiple Sclerosis
    Elisa Ridolfi
    Department of Pathophysiology and Transplantation, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Int J Mol Sci 14:4375-84. 2013
    ..Moreover, miR-223 rs1044165 polymorphism likely acts as a protective factor, while miR-23a rs3745453 variant seems to act as a risk factor for MS...
  72. doi A 66-year-old patient with vanishing white matter disease due to the p.Ala87Val EIF2B3 mutation
    Laura Ghezzi
    Department of Neurological Sciences, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy
    Neurology 79:2077-8. 2012
    ..Mutations in any of the genes encoding the 5 subunits of the Eukaryotic Initiation Factor 2B gene (EIF2B1, 2, 3, 4, and 5) can independently cause VWM.(1)...
  73. doi FUS/TLS genetic variability in sporadic frontotemporal lobar degeneration
    Claudia Cantoni
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 19:1317-22. 2010
    ..Haplotype analysis failed to detect haplotypes associated with FTLD. According to these results, FUS/TLS is not a susceptibility factor for the development of sporadic FTLD...
  74. doi In vivo confocal microscopy of conjunctival roundish bright objects: young, older, and Sjögren subjects
    Edoardo Villani
    Universita degli Studi di Milano, Milan, Italy
    Invest Ophthalmol Vis Sci 52:4829-32. 2011
    ..To evaluate the interobserver variability and to compare the measured densities with known age-related and SS-related changes...
  75. ncbi Progressive, isolated language disturbance: its significance in a 65-year-old-man. A case report with implications for treatment and review of literature
    Elio Scarpini
    Dept of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy
    J Neurol Sci 240:45-51. 2006
    ..Here, the case of a patient with progressive isolated language disturbances is presented, and further discussed on the basis of current diagnostic criteria and available guidelines for treatment...
  76. ncbi Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis
    PierLuigi Baron
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan Medical School, IRCCS Ospedale Maggiore Policlinico, Via S Sforza 35, 20122 Milan, Italy
    Muscle Nerve 32:541-4. 2005
    ..Our findings suggest a role for MCP-1 as an important molecular mediator of the injury response in ALS...
  77. ncbi Loss of epidermal growth factor regulation by cobalamin in multiple sclerosis
    Giuseppe Scalabrino
    Institute of General Pathology, University of Milan, Via Mangiagalli 31, 20133 Milan, Italy
    Brain Res 1333:64-71. 2010
    ....
  78. ncbi IP-10 and MCP-1 levels in CSF and serum from multiple sclerosis patients with different clinical subtypes of the disease
    Elio Scarpini
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy
    J Neurol Sci 195:41-6. 2002
    ..MCP-1 decrease in CSF and serum from MS patients could be related to the regulation of T-cell polarization...
  79. doi The progranulin (GRN) Cys157LysfsX97 mutation is associated with nonfluent variant of primary progressive aphasia clinical phenotype
    Francesca Caso
    Department of Neurology, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    J Alzheimers Dis 28:759-63. 2012
    ..This patient's description expands the spectrum of clinical presentations of frontotemporal lobar degeneration caused by the GRN Cys157LysfsX97 mutation...
  80. ncbi Inducible nitric oxide synthase (iNOS) in immune-mediated demyelination and Wallerian degeneration of the rat peripheral nervous system
    Giancarlo Conti
    Department of Neurological Sciences, Dino Ferrari Centre, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Exp Neurol 187:350-8. 2004
    ..These data support the hypothesis that, during cell-mediated demyelination, iNOS may influence Schwann cell-axon relationship causing axonal damage and regulating endoneurial cell life and death...
  81. ncbi Serum folate concentrations in patients with cortical and subcortical dementias
    Carlo Lovati
    Department of Neurology, L Sacco Hospital, and Department of Clinical Sciences, University of Milan, Via G B Grassi 74, I 20157 Milan, Italy
    Neurosci Lett 420:213-6. 2007
    ..2 and 46.3% versus 7.9% in controls; P<0.001). Folate deficiency characterizes FTD as well as AD. These differences observed among different clinical dementing syndromes may be related to neocortical damage...
  82. doi In vivo confocal microscopy of meibomian glands in Sjögren's syndrome
    Edoardo Villani
    Universita degli Studi di Milano, UO Oculistica Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy
    Invest Ophthalmol Vis Sci 52:933-9. 2011
    ..To evaluate morphologic changes in meibomian glands (MGs) and the status of periglandular inflammation in patients with primary and secondary Sjögren's Syndrome (SS) using in vivo confocal laser microscopy (LSCM)...
  83. ncbi Alpha1-antichymotrypsin induces TNF-alpha production and NF-kappaB activation in the murine N9 microglial cell line
    Elisa Braghin
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Neurosci Lett 467:40-2. 2009
    ..Furthermore, we show that ACT induces a significant increase in NF-kappaB nuclear translocation. Taken together, these data demonstrate that ACT might contribute to the inflammatory mechanisms present in AD senile plaques...
  84. pmc Interleukin-6 plasma level increases with age in an Italian elderly population ("The Treviso Longeva"-Trelong-study) with a sex-specific contribution of rs1800795 polymorphism
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156, Milan, Italy
    Age (Dordr) 31:155-62. 2009
    ..05, Tukey's test) was also noticed. We suggest a sex-specific pattern for genetic variability linked to inflammatory response and longevity, consistent with the age-related increase in IL-6...
  85. ncbi Production of IL-6 by human myoblasts stimulated with Abeta: relevance in the pathogenesis of IBM
    P Baron
    Department of Neurological Sciences, Centro Dino Ferrari, University of Milan School of Medicine, IRCCS Ospedale Maggiore, Milan, Italy
    Neurology 57:1561-5. 2001
    ..To determine whether amyloid-beta protein (Abeta) can induce the production of proinflammatory cytokines by cultured normal muscle cells...
  86. ncbi Genetics and neurobiology of frontotemporal lobar degeneration
    E Scarpini
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, I R C C S Ospedale Maggiore Policlinico, Milan, Italy
    Neurol Sci 27:S32-4. 2006
    ..Besides, increased cerebrospinal fluid monocyte chemotactic protein-1 and interleukin-8 levels have been observed in FTD, whereas interferon-gamma-inducible protein-10 levels were similar to controls...
  87. ncbi Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males
    C Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Genes Immun 11:497-503. 2010
    ..8% vs 70.9%; P=0.001, OR 0.52, 95% CI 0.4-0.8). Therefore, GRN haplotypes likely influence the risk of developing PPMS in males...
  88. doi Novel exon 1 progranulin gene variant in Alzheimer's disease
    F Cortini
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    Eur J Neurol 15:1111-7. 2008
    ..Progranulin (PGRN) expression is increased in activated microglia in Alzheimer's disease (AD) brain, suggesting a potential role in this pathology...
  89. ncbi DCUN1D1 is a risk factor for frontotemporal lobar degeneration
    C Villa
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    Eur J Neurol 16:870-3. 2009
    ..Frontotemporal lobar degeneration (FTLD) is considered as a proteinopathy; therefore, it is conceivable that genes encoding for factors involved in protein misfolding and/or degradation could play a role in its pathogenesis...
  90. ncbi Neuronal nitric oxide synthase C276T polymorphism increases the risk for frontotemporal lobar degeneration
    E Venturelli
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Eur J Neurol 15:77-81. 2008
    ..The C276T SNP acts as risk factor for sporadic FTLD, possibly influencing NOS1 transcription. Studies in larger populations are needed to confirm its role in PSP and CBD...
  91. ncbi The cornea in Sjogren's syndrome: an in vivo confocal study
    Edoardo Villani
    Clinica Oculistica Università degli Studi di Milano, Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Istituti di Ricovero e Cura a Carattere Scientifico, Milan, Italy
    Invest Ophthalmol Vis Sci 48:2017-22. 2007
    ..To analyze the in vivo morphology of corneal cells and nerves in dry eye associated with primary (SSI) and secondary (SSII) Sjögren's syndrome and to study its relationship with the clinical evaluation...
  92. pmc Genetics and biology of Alzheimer's disease and frontotemporal lobar degeneration
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico Via F Sforza 35, 20122, Milan, Italy
    Int J Clin Exp Med 3:129-43. 2010
    ..Some of them also influence the risk to develop FTLD. In this review, current knowledge on molecular mechanisms at the basis of AD and FTLD, as well as the role of genetics, will be presented and discussed...
  93. pmc Disease-modifying treatments for Alzheimer's disease
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122, Milan, Italy
    Ther Adv Neurol Disord 4:203-16. 2011
    ....
  94. ncbi The leukocyte expression of CD36 is low in patients with Alzheimer's disease and mild cognitive impairment
    M Giunta
    Center of Excellence on Neurodegenerative Diseases, Department of Medical Pharmacology, University of Milan, Milan, Italy
    Neurobiol Aging 28:515-8. 2007
    ..Irrespective of the mechanism(s) underlying such changes, assessment of leukocyte CD36 expression might represent an useful tool to support the diagnosis of AD and to screen MCI patients candidates to develop the disease...
  95. ncbi Menopausal transition: a possible risk factor for brain pathologic events
    S M Bonomo
    Department of Medical Pharmacology, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurobiol Aging 30:71-80. 2009
    ..g. related to glucocorticoid and interleukin-6 activities) vary during lifespan in either sex in either normalcy or neurodegenerative disorders...
  96. pmc A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk
    Ute Dreses-Werringloer
    Litwin Zucker Research Center for the Study of Alzheimer s Disease, The Feinstein Institute for Medical Research, North Shore LIJ, Manhasset, NY 11030, USA
    Cell 133:1149-61. 2008
    ..We propose that CALHM1 encodes an essential component of a previously uncharacterized cerebral Ca(2+) channel that controls Abeta levels and susceptibility to late-onset AD...
  97. ncbi ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution
    Luca Castelli
    Interdisciplinary Research Center of Autoimmune Diseases and Department of Medical Sciences, A Avogadro University of Eastern Piedmont, Novara, Italy
    J Neuroimmunol 186:193-8. 2007
    ..70). Moreover, AA patients with relapsing-remitting onset had lower relapse rate and multiple sclerosis severity score than non-AA patients...
  98. pmc Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition
    John S K Kauwe
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:8050-4. 2008
    ....
  99. ncbi Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Neurobiol Aging 28:1682-8. 2007
    ..05, Mann-Whitney test) in the Abeta(1-42)/Abeta(1-40) ratio in PSEN-1 [E318G] carriers, suggesting a peculiar biochemical effect of this mutation...
  100. ncbi Interaction between the APOE epsilon4 allele and the APH-1b c + 651T > G SNP in Alzheimer's disease
    Maura Poli
    Section of Chemistry, Faculty of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Neurobiol Aging 29:1494-501. 2008
    ....
  101. ncbi Plasma levels of beta-amyloid (1-42) in Alzheimer's disease and mild cognitive impairment
    Marzia Pesaresi
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Neurobiol Aging 27:904-5. 2006
    ..Thus, the reduction in beta-amyloid 1-42 may be a marker for AD status, specifically, a transition from normal status or MCI to AD, rather than a marker for neurodegenerative processes occurring in the disease...