Nazzareno Galie

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Primary pulmonary hypertension: insights into pathogenesis from epidemiology
    N Galie
    Institute of Cardiology, University of Bologna, Italy
    Chest 114:184S-194S. 1998
  2. ncbi Sildenafil citrate therapy for pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    N Engl J Med 353:2148-57. 2005
  3. ncbi Pulmonary arterial hypertension: therapeutic algorithm
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    Ital Heart J 6:856-60. 2005
  4. ncbi Pulmonary arterial hypertension associated to connective tissue diseases
    N Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    Lupus 14:713-7. 2005
  5. ncbi Ambrisentan therapy for pulmonary arterial hypertension
    Nazzareno Galie
    University of Bologna, Bologna, Italy
    J Am Coll Cardiol 46:529-35. 2005
  6. ncbi [Guidelines on diagnosis and treatment of pulmonary arterial hypertension]
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Italy
    Rev Esp Cardiol 58:523-66. 2005
  7. ncbi Evaluation of pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Italy
    Curr Opin Cardiol 19:575-81. 2004
  8. ncbi Comparative analysis of clinical trials and evidence-based treatment algorithm in pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    J Am Coll Cardiol 43:81S-88S. 2004
  9. ncbi The endothelin system in pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, via Massarent 9, 40138 Bologna, Italy
    Cardiovasc Res 61:227-37. 2004
  10. ncbi Prostanoids for pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    Am J Respir Med 2:123-37. 2003

Detail Information

Publications34

  1. ncbi Primary pulmonary hypertension: insights into pathogenesis from epidemiology
    N Galie
    Institute of Cardiology, University of Bologna, Italy
    Chest 114:184S-194S. 1998
    ..Prospective registries are very useful in coordinating the collection of epidemiologic data, and new technologies, such as informatics, may improve the management and the continuous updating of the databases...
  2. ncbi Sildenafil citrate therapy for pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    N Engl J Med 353:2148-57. 2005
    ....
  3. ncbi Pulmonary arterial hypertension: therapeutic algorithm
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    Ital Heart J 6:856-60. 2005
    ..Combination therapy can be attempted in selected cases. Balloon atrial septostomy and/or lung transplantation are indicated for refractory patients or when medical treatments are unavailable...
  4. ncbi Pulmonary arterial hypertension associated to connective tissue diseases
    N Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    Lupus 14:713-7. 2005
    ..Also, the endothelin receptor antagonists bosentan and sitaxentan, the phosphodyesterase-type-5 sildenafil and subcutaneous treprostinil have shown favourable results...
  5. ncbi Ambrisentan therapy for pulmonary arterial hypertension
    Nazzareno Galie
    University of Bologna, Bologna, Italy
    J Am Coll Cardiol 46:529-35. 2005
    ..The purpose of this study was to examine the efficacy and safety of four doses of ambrisentan, an oral endothelin type A receptor-selective antagonist, in patients with pulmonary arterial hypertension (PAH)...
  6. ncbi [Guidelines on diagnosis and treatment of pulmonary arterial hypertension]
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Italy
    Rev Esp Cardiol 58:523-66. 2005
  7. ncbi Evaluation of pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Italy
    Curr Opin Cardiol 19:575-81. 2004
    ..The purpose of this review is to analyze the current knowledge of the evaluation of PAH patients...
  8. ncbi Comparative analysis of clinical trials and evidence-based treatment algorithm in pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    J Am Coll Cardiol 43:81S-88S. 2004
    ..Combination therapy can be attempted in selected cases. Both balloon atrial septostomy and lung transplantation are indicated for refractory patients or where medical treatment is unavailable...
  9. ncbi The endothelin system in pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, via Massarent 9, 40138 Bologna, Italy
    Cardiovasc Res 61:227-37. 2004
    ..Additional trials with these drugs are currently ongoing. In conclusion, the hypothesis that the ET-1 system over-activation can be successfully antagonised in patients with PAH has been clearly demonstrated...
  10. ncbi Prostanoids for pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    Am J Respir Med 2:123-37. 2003
    ....
  11. ncbi Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and doppler measures in patients with pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Italy
    J Am Coll Cardiol 41:1380-6. 2003
    ..The purpose of this study was to investigate the effects of bosentan (125 or 250 mg twice daily) on echocardiographic and Doppler variables in 85 patients with World Health Organization class III or IV pulmonary arterial hypertension (PAH)...
  12. ncbi The new clinical trials on pharmacological treatment in pulmonary arterial hypertension
    N Galie
    Eur Respir J 20:1037-49. 2002
    ..These new therapeutic options will be available in the near future and will allow tailoring of the most appropriate treatment to the single patient, according to an individualised benefit-to-risk ratio...
  13. ncbi Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    J Am Coll Cardiol 39:1496-502. 2002
    ....
  14. ncbi Emerging medical therapies for pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Italy
    Prog Cardiovasc Dis 45:213-24. 2002
    ....
  15. ncbi Management of pulmonary arterial hypertension associated with congenital systemic-to-pulmonary shunts and Eisenmenger's syndrome
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    Drugs 68:1049-66. 2008
    ..A treatment algorithm based on the one used in the treatment of PAH patients is proposed for patients with PAH associated with corrected and uncorrected congenital systemic-to-pulmonary shunts and Eisenmenger's syndrome...
  16. doi Tadalafil therapy for pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Circulation 119:2894-903. 2009
    ..Treatment options for pulmonary arterial hypertension target the prostacyclin, endothelin, or nitric oxide pathways. Tadalafil, a phosphodiesterase type-5 inhibitor, increases cGMP, the final mediator in the nitric oxide pathway...
  17. ncbi Pulmonary arterial hypertension in the pediatric age
    Andrea Donti
    Pediatric Cardiology, Policlinico S Orsola Malpighi, University of Bologna, Italy
    J Cardiovasc Med (Hagerstown) 8:72-7. 2007
    ....
  18. ncbi Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy
    Circulation 117:3010-9. 2008
    ..Ambrisentan is a propanoic acid-based, A-selective endothelin receptor antagonist for the once-daily treatment of pulmonary arterial hypertension...
  19. pmc A meta-analysis of randomized controlled trials in pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    Eur Heart J 30:394-403. 2009
    ..We performed a meta-analysis of all randomized controlled trials with drugs published in this condition...
  20. ncbi Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells
    Benedetta Tantini
    Department of Biochemistry, G Moruzzi University of Bologna, Bologna, Italy
    Basic Res Cardiol 100:131-8. 2005
    ..We conclude that sildenafil exerts an antiproliferative effect on human PASMC that is mediated by an interaction between the cGMP-PKG and the cAMP-PKA activated pathways, leading to inhibition of PDGF-mediated activation of the ERK...
  21. ncbi Clinical worsening in trials of pulmonary arterial hypertension: results and implications
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    Curr Opin Pulm Med 16:S11-9. 2010
    ....
  22. doi Pulmonary artery intimal sarcoma. Problems in the differential diagnosis
    Domenico Attinà
    U O Radiologia, Dipartimento Cardio Toraco Vascolare, Azienda Ospedaliero universitaria S Orsola Malpighi, Via Massarenti 9, 40128, Bologna, Italy
    Radiol Med 118:1259-68. 2013
    ....
  23. ncbi Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study
    Nazzareno Galie
    Istituto di Cardiologia, Universita di Bologna, Via Massarenti, 9 IT 40138, Bologna, Italy
    Circulation 114:48-54. 2006
    ..Theoretically, interventions that have some effect on the systemic vascular bed could worsen the shunt and increase hypoxemia...
  24. ncbi Prognostic implications of serial assessments of pulmonary hypertension in severe chronic heart failure
    Francesco Grigioni
    Cardiology Institute, University of Bologna, Bologna, Italy
    J Heart Lung Transplant 25:1241-6. 2006
    ..It is unknown whether time-related changes of pulmonary hypertension (PH) have prognostic relevance in severe chronic heart failure (CHF)...
  25. doi Pulmonary hypertension and systemic sclerosis: the role of high-resolution computed tomography
    Maurizio Zompatori
    Department of Radiology, Ospedale Sant Orsola, Bologna, Italy
    Radiol Med 118:1360-72. 2013
    ..In addition, we assessed the role of high-resolution computed tomography (HRCT) in the diagnostic and therapeutic pathway for such patients...
  26. doi Current era survival of patients with pulmonary arterial hypertension associated with congenital heart disease: a comparison between clinical subgroups
    Alessandra Manes
    Institute of Cardiology, Bologna University Hospital, Via Massarenti 9, Bologna 40138, Italy
    Eur Heart J 35:716-24. 2014
    ....
  27. doi Current therapeutic approaches to pulmonary arterial hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy
    Rev Esp Cardiol (Engl Ed) 63:708-24. 2010
    ..However, drugs intended specifically for the treatment of pulmonary arterial hypertension may be considered in inoperable cases or after suboptimal surgery. ..
  28. doi Sodium butyrate inhibits platelet-derived growth factor-induced proliferation and migration in pulmonary artery smooth muscle cells through Akt inhibition
    Silvia Cantoni
    Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, Bologna, Italy
    FEBS J 280:2042-55. 2013
    ..These findings may provide novel perspectives on the use of histone deacetylase inhibitors in PAH...
  29. ncbi Transcatheter aortic valve implantation for severe autograft regurgitation after Ross operation
    Francesco Saia
    Institute of Cardiology, University of Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
    EuroIntervention 10:141-5. 2014
    ..The procedure was successful and the in-hospital course was uncomplicated. During follow-up, pulmonary pressure and resistances were significantly lowered and at four years the patient showed markedly improved exercise tolerance...
  30. doi Lung neovascularity in pulmonary arterial hypertension associated with congenital heart defects and idiopathic pulmonary arterial hypertension: study of 198 patients
    Cecilia Modolon
    Department of Cardio Thoracic Vascular, Division of Cardio Thoracic Radiology, Policlinico S Orsola Malpighi, Via Massarenti 9, 40100 Bologna, Italy
    Eur Radiol 22:1059-66. 2012
    ....
  31. ncbi Pulmonary microvascular disease in chronic thromboembolic pulmonary hypertension
    Nazzareno Galie
    Institute of Cardiology, University of Bologna, Bologna, Italy and Division of Pulmonary and Critical Care Medicine, University of California, San Diego, La Jolla, California, USA
    Proc Am Thorac Soc 3:571-6. 2006
    ....
  32. ncbi Acute hand ischemia after radial intervention in patient with CREST-associated pulmonary hypertension: successful treatment with manual thromboaspiration
    Nevio Taglieri
    Institute of Cardiology, Bologna University, St Orsola Malpighi Hospital, Via Massarenti 9, 40138, Bologna, Italy
    J Invasive Cardiol 25:89-91. 2013
    ..This case shows that radial occlusion, one of the most common and usually asymptomatic complications following transradial cardiac catheterization, may cause severe hand ischemia in patients with small-vessel inflammatory disease...
  33. ncbi Pulmonary endarterectomy: is there an alternative to profound hypothermia with cardiocirculatory arrest?
    Piero Maria Mikus
    Heart and Lung Transplantation Program, S Orsola Malpighi Hospital, University of Bologna, Via Massarenti n 9, Bologna, Italy
    Eur J Cardiothorac Surg 30:563-5. 2006
    ..The initial encouraging results have convinced us to apply systematically this technique in the cases operated in our center, even though further investigations are necessary to fully examine this technique...
  34. ncbi Can "inoperable" congenital heart defects become operable in patients with pulmonary arterial hypertension? Dream or reality?
    Maurice Beghetti
    Pediatric Cardiology Unit, Department of the Child and Adolescent, Children s University Hospital, 6 Rue Willy Donze, Geneva, Switzerland
    Congenit Heart Dis 7:3-11. 2012
    ....