Nicoletta Galeotti

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi request reprint Signaling pathway of morphine induced acute thermal hyperalgesia in mice
    Nicoletta Galeotti
    Department of Clinical and Preclinical Pharmacology, University of Florence, Florence, Italy
    Pain 123:294-305. 2006
  2. ncbi request reprint Alpha-2 agonists induce amnesia through activation of the Gi-protein signalling pathway
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuroscience 126:451-60. 2004
  3. ncbi request reprint Blockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuropharmacology 50:309-16. 2006
  4. doi request reprint St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes
    Nicoletta Galeotti
    Department of Neurosciences, Psychology, Drug Area and Child Health, NEUROFARBA, Section of Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy Electronic address
    Fitoterapia 92:23-33. 2014
  5. doi request reprint St. John's wort reversal of meningeal nociception: a natural therapeutic perspective for migraine pain
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Phytomedicine 20:930-8. 2013
  6. doi request reprint Pleiotropic effect of histamine H4 receptor modulation in the central nervous system
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuropharmacology 71:141-7. 2013
  7. pmc Inhibition of the PKCγ-ε pathway relieves from meningeal nociception in an animal model: an innovative perspective for migraine therapy?
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, Florence, 50139, Italy
    Neurotherapeutics 10:329-39. 2013
  8. doi request reprint Reversal of NO-induced nociceptive hypersensitivity by St. John's wort and hypericin: NF-κB, CREB and STAT1 as molecular targets
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, 50139, Florence, Italy
    Psychopharmacology (Berl) 227:149-63. 2013
  9. doi request reprint St. John's wort relieves pain in an animal model of migraine
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Florence, Italy
    Eur J Pain 17:369-81. 2013
  10. doi request reprint Regionally selective activation and differential regulation of ERK, JNK and p38 MAP kinase signalling pathway by protein kinase C in mood modulation
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, Florence, Italy
    Int J Neuropsychopharmacol 15:781-93. 2012

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Signaling pathway of morphine induced acute thermal hyperalgesia in mice
    Nicoletta Galeotti
    Department of Clinical and Preclinical Pharmacology, University of Florence, Florence, Italy
    Pain 123:294-305. 2006
    ..The clinical management of pain by morphine may be revisited in light of the identification of the signaling molecules of the hyperalgesic pathway...
  2. ncbi request reprint Alpha-2 agonists induce amnesia through activation of the Gi-protein signalling pathway
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuroscience 126:451-60. 2004
    ..These results indicate the involvement of Gi1, Gi3, and Go1, but not Gi2 and Go2, protein subtypes in the transduction mechanism responsible for the induction of amnesia by clonidine and guanabenz...
  3. ncbi request reprint Blockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuropharmacology 50:309-16. 2006
    ..In particular, the blockade of both InsP3Rs and RyRs appears to play an important role in the induction of an antidepressant-like effect, whereas the stimulation of these receptors is involved in a depressant-like response of mice...
  4. doi request reprint St. John's Wort seed and feverfew flower extracts relieve painful diabetic neuropathy in a rat model of diabetes
    Nicoletta Galeotti
    Department of Neurosciences, Psychology, Drug Area and Child Health, NEUROFARBA, Section of Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy Electronic address
    Fitoterapia 92:23-33. 2014
    ..Rats undergoing treatment with SJW and feverfew did not show any behavioral side effect or sign of altered locomotor activity. Our results suggest that SJW and feverfew extracts may become new therapeutic perspectives for painful DPN. ..
  5. doi request reprint St. John's wort reversal of meningeal nociception: a natural therapeutic perspective for migraine pain
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Phytomedicine 20:930-8. 2013
    ..These results might suggest SJW as an innovative and safe perspective for migraine pain. ..
  6. doi request reprint Pleiotropic effect of histamine H4 receptor modulation in the central nervous system
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuropharmacology 71:141-7. 2013
    ..These results show the antinociceptive, antiamnesic, anxiolytic and anorexant effects induced by neuronal H4R agonism, suggesting that H4 modulators may have broader utility further the control of inflammatory and immune processes...
  7. pmc Inhibition of the PKCγ-ε pathway relieves from meningeal nociception in an animal model: an innovative perspective for migraine therapy?
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, Florence, 50139, Italy
    Neurotherapeutics 10:329-39. 2013
    ..These results suggest the relevance of the PKC-mediated pathway in the induction of meningeal nociception and might help clarify the etiopathology of migraines. We can suggest PKC as a new target for migraine pain...
  8. doi request reprint Reversal of NO-induced nociceptive hypersensitivity by St. John's wort and hypericin: NF-κB, CREB and STAT1 as molecular targets
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, 50139, Florence, Italy
    Psychopharmacology (Berl) 227:149-63. 2013
    ..John's wort (SJW), is a medicinal plant mainly used as antidepressant with a favorable safety profile than standard antidepressants. Some studies have also documented other SJW bioactivities, including pain modulation...
  9. doi request reprint St. John's wort relieves pain in an animal model of migraine
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Florence, Italy
    Eur J Pain 17:369-81. 2013
    ..We here investigated the pain-relieving property of SJW and its main components, hypericin and flavonoids, in a mouse model induced by nitric oxide (NO) donors administration...
  10. doi request reprint Regionally selective activation and differential regulation of ERK, JNK and p38 MAP kinase signalling pathway by protein kinase C in mood modulation
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, Florence, Italy
    Int J Neuropsychopharmacol 15:781-93. 2012
    ..An antidepressant-like phenotype produced by acute blockade of MAPK signalling was also demonstrated...
  11. doi request reprint St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Biochem Pharmacol 79:1327-36. 2010
    ..Our results indicate SJW as a prolonged antihyperalgesic treatment through inhibition of PKC isoforms and their phosphorylation...
  12. doi request reprint Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuroscience 153:814-22. 2008
    ..A selective involvement of RyR1 and RyR3 in supraspinal muscarinic analgesia was demonstrated whereas RyR2 appears not to play an essential role in acute thermal and inflammatory pain...
  13. doi request reprint An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuropharmacology 55:1156-64. 2008
    ..These results indicate the involvement of the InsP3R-mediated pathway in the modulation of depressive conditions and may be useful for the development of new therapeutical strategies for the treatment of mood disorders...
  14. doi request reprint Antidepressant phenotype by inhibiting the phospholipase Cβ(1)--protein kinase Cγ pathway in the forced swim test
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, 50139 Florence, Italy
    Neuropharmacology 60:937-43. 2011
    ..We demonstrate that selective blockade of PLCβ(1)-PKCγ signalling pathway produces an antidepressant-like phenotype in mice...
  15. doi request reprint A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini, Florence, Italy
    J Neurochem 106:2385-94. 2008
    ..These findings identify cerebral RyRs as critical targets underlying depressive states and should facilitate the comprehension of the pathophysiology of mood disorders and help developing of new therapeutical strategies...
  16. ncbi request reprint Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuroscience 149:409-20. 2007
    ..These results indicate a selective involvement of type 2 and 3 IP3R in central muscarinic antinociception in mice...
  17. doi request reprint Selective modulation of the PKCɛ/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, 50139 Florence, Italy
    Neuropharmacology 62:289-96. 2012
    ..This article is part of a Special Issue entitled 'Anxiety and Depression'...
  18. ncbi request reprint Role of intracellular calcium in acute thermal pain perception
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Neuropharmacology 47:935-44. 2004
    ....
  19. ncbi request reprint H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuropharmacology 47:295-303. 2004
    ..These results indicate a role for the PLC-PKC pathway in central H(1)-induced hyperalgesia in mice. Furthermore, activation of PLC-IP(3) did not appear to play a major role in the modulation of pain perception by H(1)-receptor agonists...
  20. doi request reprint A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50 139 Florence, Italy
    J Pain 11:149-59. 2010
    ..In particular, the presence of hypericin was fundamental to induce both thermal and chemical antinociception through the inhibition of the PKC activity, whereas hyperforin selectively produced a thermal opioid antinociception...
  21. pmc Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, I 50139 Florence, Italy
    Learn Mem 15:315-23. 2008
    ..These findings also showed the involvement of type 2 and type 3 RyR in the modulation of memory functions identifying these cerebral RyR isoforms as critical targets underlying memory processes...
  22. ncbi request reprint Acetyl-L-carnitine requires phospholipase C-IP3 pathway activation to induce antinociception
    Nicoletta Galeotti
    Department of Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuropharmacology 47:286-94. 2004
    ..These results indicate that central ALCAR analgesia in mice requires the activation of the PLC-IP(3) pathway. By contrast, the simultaneous activation of PKC may represent a pathway of negative modulation of ALCAR antinociception...
  23. ncbi request reprint Ryanodine receptors are involved in muscarinic antinociception in mice
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Behav Brain Res 164:165-71. 2005
    ..In particular, the stimulation of RyRs appears to play an important role in the increase of the pain threshold produced by physostigmine and oxotremorine in mice...
  24. ncbi request reprint Molecular interaction in the mouse PAG between NMDA and opioid receptors in morphine-induced acute thermal nociception
    Carla Ghelardini
    Department of Clinical and Preclinical Pharmacology, University of Florence, Italy
    J Neurochem 105:91-100. 2008
    ..Protein kinase C appears to be the key element that links microOR activation by morphine administration to mice with the recruitment of the NMDA/glutamatergic system involved in the thermal hyperalgesic response...
  25. pmc The central analgesia induced by antimigraine drugs is independent from Gi proteins: superiority of a fixed combination of indomethacin, prochlorperazine and caffeine, compared to sumatriptan, in an in vivo model
    Carla Ghelardini
    Department of Pharmacology, University of Florence, Viale G Pieraccini, 6, 50139 Florence, Italy
    J Headache Pain 10:435-40. 2009
    ..This study suggests that the central antinociceptive action induced by antimigraine drugs is independent from Gi proteins...
  26. ncbi request reprint Role of Gi proteins in the antidepressant-like effect of amitriptyline and clomipramine
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    Neuropsychopharmacology 27:554-64. 2002
    ....
  27. pmc 4-methyl benzylamine stimulates food consumption and counteracts the hypophagic effects of amphetamine acting on brain Shaker-like Kv1.1 channels
    Renato Pirisino
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, Florence 50134, Italy
    Br J Pharmacol 147:218-24. 2006
    ..We hypothesize that 4-MBZ elicits hyperphagic effects probably by opening Shaker-like Kv1.1 subtypes in the brain, whereas AMPH and BZ are hypophagic by blocking these channels...
  28. doi request reprint Salvianolic acid B and its liposomal formulations: anti-hyperalgesic activity in the treatment of neuropathic pain
    Benedetta Isacchi
    Department of Pharmaceutical Sciences, University of Florence, via U Schiff 6, Sesto Fiorentino, Florence, Italy
    Eur J Pharm Sci 44:552-8. 2011
    ..p. administration and the effect was still significant at 45 min. Thus, PEGylated formulation ameliorated the performance of drug delaying, increasing and prolonging in time its antihyperalgesic effect...
  29. doi request reprint Antihyperalgesic activity of verbascoside in two models of neuropathic pain
    Benedetta Isacchi
    Department of Pharmaceutical Sciences, University of Florence, Sesto Fiorentino Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    J Pharm Pharmacol 63:594-601. 2011
    ..This study reports on the rapid isolation of verbascoside from Lippia citriodora H.B.K. (Verbenaceae), an inexpensive and widespread source, and the evaluation of its antihyperalgesic activity...
  30. ncbi request reprint Acetyl-l-carnitine induces muscarinic antinocieption in mice and rats
    Carla Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139, Florence, Italy
    Neuropharmacology 43:1180-7. 2002
    ..In the antinociceptive dose-range, ALCAR did not impair mouse performance evaluated by the rota-rod and hole-board tests...
  31. ncbi request reprint Menthol: a natural analgesic compound
    Nicoletta Galeotti
    Department of Pharmacology, Viale G Pieraccini 6, University of Florence, I 50139, Florence, Italy
    Neurosci Lett 322:145-8. 2002
    ..o.; 10-30 microg per mouse i.c.v.) was unable to modify the pain threshold. These results indicate that (-)-menthol is endowed with analgesic properties mediated through a selective activation of kappa-opioid receptors...
  32. ncbi request reprint Inactivation of Gi proteins induces an antidepressant-like effect in the mouse forced-swimming test
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, Univeristy of Florence, Viale G Pieraccini 6, I 50139, Florence, Italy
    Neuropharmacology 43:457-65. 2002
    ..These results indicate the involvement of Gi(2), Gi(3), Go(1), and Go(2), but not Gi(1), protein subtypes in the transduction mechanism responsible for the induction of an antidepressant-like effect in the mouse forced swimming test...
  33. ncbi request reprint The phospholipase C-IP3 pathway is involved in muscarinic antinociception
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 10539 Florence, Italy
    Neuropsychopharmacology 28:888-97. 2003
    ..These results indicate a role for the PLC-IP(3) pathway in central muscarinic analgesia in mice. Furthermore, activation of PKC by cholinomimetic drugs may represent a pathway of negative modulation of muscarinic antinociception...
  34. ncbi request reprint Methylamine: a new endogenous modulator of neuron firing?
    Renato Pirisino
    Department of Pharmacology, University of Florence, Florence, Italy
    Med Sci Monit 11:RA257-61. 2005
    ..Moreover, the activity of methylamine as an inducer of NO release suggests a role for the amine and for the enzymatic activity that degrades it in neurodegenerative diseases...
  35. ncbi request reprint Prochlorperazine induces central antinociception mediated by the muscarinic system
    Carla Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Pharmacol Res 50:351-8. 2004
    ..On the basis of the above data, it can be postulated that prochlorperazine exerted an antinociceptive effect mediated by a central cholinergic mechanism...
  36. ncbi request reprint Indomethacin, alone and combined with prochlorperazine and caffeine, but not sumatriptan, abolishes peripheral and central sensitization in in vivo models of migraine
    Carla Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Firenze, Italy
    J Pain 5:413-9. 2004
    ....
  37. ncbi request reprint Antihistamine antinociception is mediated by Gi-protein activation
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuroscience 109:811-8. 2002
    ..These results suggest an important role played by the Gi-protein pathway in the transduction mechanism involved in the enhancement of the pain threshold produced by H(1)-antihistamines...
  38. ncbi request reprint Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, I 50139 Florence, Italy
    Behav Brain Res 153:409-17. 2004
    ..These results indicate that clonidine and guanabenz impaired memory processes in a mouse passive avoidance paradigm through the selective activation of the alpha2A-adrenoceptor subtype...
  39. ncbi request reprint Antinociception induced by SM 32 depends on a central cholinergic mechanism
    C Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Pharmacol Res 35:141-7. 1997
    ..On the basis of the above data, it can be postulated that SM 32 exerts its antinociceptive effect through a potentiation of central cholinergic transmission...
  40. pmc Role of potassium channels in the antinociception induced by agonists of alpha2-adrenoceptors
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Florence, Italy
    Br J Pharmacol 126:1214-20. 1999
    ..7. The present data demonstrate that both K(ATP) and mKv1.1 K+ channels represent an important step in the transduction mechanism underlying central antinociception induced by activation of alpha2 adrenoceptors...
  41. ncbi request reprint Antiamnesic activity of metoclopramide, cisapride and SR-17 in the mouse passive avoidance test
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Pharmacol Res 36:59-67. 1997
    ..These results suggest that metoclopramide, cisapride and SR-17 play an important role in the modulation of memory processes. On these bases, these compounds could be useful in the treatment of cognitive deficits...
  42. ncbi request reprint AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram)
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Naunyn Schmiedebergs Arch Pharmacol 368:538-45. 2003
    ..These results suggest that DM 232 and DM 235 act as cognition enhancers through the activation of the AMPA-mediated neurotransmission system...
  43. pmc Differential prevention of morphine amnesia by antisense oligodeoxynucleotides directed against various Gi-protein alpha subunits
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G. Pieraccini 6, I-50139 Florence, Italy
    Br J Pharmacol 133:267-74. 2001
    ..These results suggest the important role played by Gi1 and Gi3 protein subtypes in the transduction mechanism involved in the impairment of memory processes produced by morphine...
  44. ncbi request reprint Amitriptyline and clomipramine activate Gi-protein signaling pathway in the induction of analgesia
    Carla Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Naunyn Schmiedebergs Arch Pharmacol 365:1-7. 2002
    ..These results indicate that amitriptyline and clomipramine induce their analgesic effect by activating all three subtypes of the Gi-proteins...
  45. ncbi request reprint Gi/o proteins: expression for direct activation enquiry
    Lorenzo Di Cesare Mannelli
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50134 Florence, Italy
    Protein Expr Purif 47:303-10. 2006
    ..Our results show that recombinant subunits are stable, properly folded and, fully active, which makes them suitable candidates for functional studies...
  46. ncbi request reprint Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine
    Nicoletta Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy
    Pharmacol Res 46:245-50. 2002
    ..These data provide the pharmacologic evidence of the efficacy of IndoProCaf in reverting hyperalgesia, a condition of reduction of pain threshold similar to that occurring in migraine...
  47. ncbi request reprint Antisense knockdown of the Shaker-like Kv1.1 gene abolishes the central stimulatory effects of amphetamines in mice and rats
    Carla Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence Viale Pieraccini, Italy
    Neuropsychopharmacology 28:1096-105. 2003
    ..Our results suggest that the stimulant effects of AMPH and chemically related compounds, but not COC, require the presence of functionally active Kv1.1 channels in the brain...
  48. pmc Methylamine, but not ammonia, is hypophagic in mouse by interaction with brain Kv1.6 channel subtype
    Renato Pirisino
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50134 Florence, Italy
    Br J Pharmacol 142:381-9. 2004
    ..6 is required only for the activity of MET, and confirms the different action mechanism of ammonia and MET...
  49. ncbi request reprint Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action
    Nicoletta Cesari
    Dipartimento di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy
    J Med Chem 49:7826-35. 2006
    ..The antinociception of some of the most interesting new molecules was completely prevented by pretreatment with alpha2-antagonist yohimbine, suggesting the involvement of alpha2-adrenoceptors, as with prototype A...
  50. ncbi request reprint [(3-Chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents
    Maria Paola Giovannoni
    Dipartimento di Scienze Farmaceutiche, Universita di Firenze, Via Gino Capponi 9, 50121 Florence, Italy
    J Med Chem 46:1055-9. 2003
    ..Furthermore, they were also active after icv administration and in the presence of a chemical, painful stimulus (abdominal constriction test)...
  51. ncbi request reprint Design, synthesis, and preliminary pharmacological evaluation of a set of small molecules that directly activate gi proteins
    Dina Manetti
    Dipartimento di Scienze Farmaceutiche, Universita di Firenze, via U Schiff 6, I 50019 Sesto Fiorentino FI, Italy
    J Med Chem 48:6491-503. 2005
    ..Some of the compounds synthesized and found to be active may be useful leads to develop more potent and selective Gi protein modulators...
  52. ncbi request reprint Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs
    Serena Scapecchi
    Dipartimento di Scienze Farmaceutiche, Universita di Firenze, Via G Capponi 9, I 50121, Firenze, Italy
    Bioorg Med Chem 12:71-85. 2004
    ..Moreover, two compounds of the series (5 and 6) were found endowed with analgesic activity on a rat model of neuropathic pain at the dose of 1 mg/kg...
  53. ncbi request reprint Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage
    Gabriella Guerrini
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Firenze, Via U Schiff, 6, 50019 Polo Scientifico, Sesto Fiorentino Firenze, Italy
    Bioorg Med Chem 15:2573-86. 2007
    ..These compounds were evaluated also for their binding at Benzodiazepine site on GABA(A) receptor complex (GABA(A)/BzR complex) subtype to evaluate their subtype selectivity...
  54. ncbi request reprint Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies
    Vittoria Colotta
    Dipartimento di Scienze Farmaceutiche, Laboratorio di Progettazione, Sintesi e Studio di Eterocicli Biologicamente Attivi, Polo Scientifico, Universita degli Studi di Firenze, Sesto Fiorentino, FI, Italy
    J Med Chem 49:6015-26. 2006
    ..To rationalize the trend of affinities of the reported derivatives, an intensive molecular modeling study was carried out by docking compounds to models of the Gly/NMDA, AMPA, and KA receptors...
  55. ncbi request reprint Effect of K+ channel modulation on mouse feeding behaviour
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Eur J Pharmacol 329:1-8. 1997
    ..The integrity and functionality of central K+ channels appears, therefore, to be fundamental in the regulation of food intake by mice...
  56. pmc Methylamine and benzylamine induced hypophagia in mice: modulation by semicarbazide-sensitive benzylamine oxidase inhibitors and aODN towards Kv1.1 channels
    R Pirisino
    Department of Preclinical and Clinical Pharmacology, Viale Pieraccini, 6, 50134 Florence, Italy
    Br J Pharmacol 134:880-6. 2001
    ..1 blocking activity. Through a reduction of the endogenous breakdown of MET, Bz-SSAO inhibitors enhance the central pharmacological activity of this amine...
  57. ncbi request reprint M1 receptor activation is a requirement for arecoline analgesia
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Farmaco 56:383-5. 2001
    ..This effect was detected 24 h after the last i.c.v. injection of aODN. These results indicate that arecoline antinociception is mediated by the activation of central M1 muscarinic receptors...
  58. ncbi request reprint DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer
    C Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, 50139 Florence, Italy
    Naunyn Schmiedebergs Arch Pharmacol 365:419-26. 2002
    ..Indeed, its potency is about 1,000 times higher than that of the most active piracetam-like compounds...
  59. ncbi request reprint Pharmacological identification of SM-21, the novel sigma(2) antagonist
    C Ghelardini
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, University of Florence, I 50139, Florence, Italy
    Pharmacol Biochem Behav 67:659-62. 2000
    ..5 microl) in the red nucleus. These data indicate that SM-21 is a potent and selective sigma(2) antagonist...
  60. pmc Loss of muscarinic antinociception by antisense inhibition of M(1) receptors
    C Ghelardini
    Department of Pharmacology, Viale G Pieraccini 6, University of Florence, I 50139 Florence, Italy
    Br J Pharmacol 129:1633-40. 2000
    ..These results indicate that activation of M(1) muscarinic receptor subtype is fundamental to induce central cholinergic analgesia in mice...
  61. doi request reprint Supraspinal role of protein kinase C in oxaliplatin-induced neuropathy in rat
    M Norcini
    Department of Clinical and Preclinical Pharmacology, University of Florence, Italy
    Pain 146:141-7. 2009
    ....
  62. ncbi request reprint Local anaesthetic activity of the essential oil of Lavandula angustifolia
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Planta Med 65:700-3. 1999
    ....
  63. ncbi request reprint Binding profiles of a series of 2-arylpropionic acid esters on cloned human muscarinic receptor subtypes (m1-m5) and their relationship to nootropic activity
    C Ghelardini
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Arzneimittelforschung 49:483-8. 1999
    ..p.) in the mouse passive-avoidance test. Compounds 1 and 7, at the highest antiamnesic doses, do not modify motor coordination and spontaneous motility as evaluated by the rota-rod test and Animex apparatus experiments...
  64. ncbi request reprint Antisense 'knockdowns' of M1 receptors induces transient anterograde amnesia in mice
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Neuropharmacology 38:339-48. 1999
    ..Neither aODN, dODN nor vehicle produced any behavioral impairment of mice. These results indicate that the integrity and functionality of M1 receptors are fundamental in the modulation of memory processes...
  65. ncbi request reprint Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers
    M N Romanelli
    Dipartimento di Scienze Farmaceutiche, University of Florence, Sesto Fiorentino, Italy
    CNS Drug Rev 12:39-52. 2006
    ..In vitro experiments, performed on hippocampal slices, also supported the hypothesis of a role of the AMPA receptors for the cognition-enhancing properties of unifiram and sunifiram...
  66. ncbi request reprint Local anaesthetic activity of beta-caryophyllene
    C Ghelardini
    Department of Pharmacology, University of Florence, Italy
    Farmaco 56:387-9. 2001
    ..In conclusion, these data evidence the local anaesthetic activity of beta-caryophyllene, which appears to be strictly dependent on its chemical structure...
  67. ncbi request reprint Central cholinergic challenging of migraine by testing second-generation anticholinesterase drugs
    M Nicolodi
    Interuniversity Center, Neurochemistry and Clinical Pharmacology of Idiopathic Headache, viale G Pieraccini 18, 1 50139, Florence, Italy
    Headache 42:596-602. 2002
    ..Clinical results also indicate that the activation of the cholinergic system can represent a novel prophylactic approach to migraine...
  68. ncbi request reprint Diphenhydramine-induced amnesia is mediated by Gi-protein activation
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuroscience 122:471-8. 2003
    ..These results suggest the important role played by the Gi(1)- and Gi(2)-protein pathway in the transduction mechanism involved in the impairment of memory processes produced by the H(1)-antihistamine diphenhydramine...
  69. ncbi request reprint Hypofunctionality of Gi proteins as aetiopathogenic mechanism for migraine and cluster headache
    N Galeotti
    Department of Pharmacology, University of Florence, Italy
    Cephalalgia 21:38-45. 2001
    ..These results indicate Gi protein hypofunctionality as an aetiopathogenic mechanism in migraine and cluster headache...
  70. doi request reprint Pharmacological in vivo test to evaluate the bioavailability of some St John's Wort innovative oral preparations
    B Isacchi
    Department of Pharmaceutical Sciences, University of Florence, Italy
    Phytother Res 23:197-205. 2009
    ....
  71. ncbi request reprint Neurotransmitter role of endogenous morphine in CNS
    Massimo Guarna
    Department of Anatomical and Biomedical Sciences, University of Siena, Italy
    Med Sci Monit 11:RA190-193. 2005
    ..Evidence has been found for its endogenous synthesis in animal tissues as well. These findings indicate that endogenous morphine might function as neuromodulator/neurotransmitter agent in the CNS...
  72. ncbi request reprint Effects of endogenous morphine deprivation on memory retention of passive avoidance learning in mice
    Massimo Guarna
    Department of Anatomical and Biomedical Sciences, University of Siena, Italy
    Int J Neuropsychopharmacol 7:311-9. 2004
    ..These findings support a role for endogenous morphine in weakening memory processes under stress conditions...
  73. ncbi request reprint 4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs
    Dina Manetti
    Dipartimento di Scienze Farmaceutiche, Universita di Firenze, Via G Capponi 9, I 50121, Firenze, Italy
    Bioorg Med Chem Lett 13:2303-6. 2003
    ..One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease...
  74. ncbi request reprint Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity
    Maurizio Anzini
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via A Moro, 53100 Siena, Italy
    J Med Chem 46:3853-64. 2003
    ..Finally, the potential antinociceptive and antiamnesic properties of compounds 6e and 6i have been investigated by means of the hot-plate and passive avoidance test in mice, respectively...
  75. ncbi request reprint Synthesis and biological evaluation of chiral alpha-aminoanilides with central antinociceptive activity
    Filomena Corbo
    Department of Pharmaceutical Chemistry, University of Bari, Via E Orabona n 4, 70125 Bari, Italy
    J Med Chem 50:1907-15. 2007
    ..Among all the synthesized compounds, 3f showed antinociceptive properties with a good enantioselective index...