Angiolo Gadducci

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. doi request reprint Surveillance procedures for patients treated for endometrial cancer: a review of the literature
    Enrico Sartori
    Department of Gynecology and Obstetrics, University of Brescia, Brescia, Italy
    Int J Gynecol Cancer 20:985-92. 2010
  2. doi request reprint Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Crit Rev Oncol Hematol 83:71-83. 2012
  3. doi request reprint Antiangiogenic agents in advanced, persistent or recurrent endometrial cancer: a novel treatment option
    Angiolo Gadducci
    Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa 56127, Italy
    Gynecol Endocrinol 29:811-6. 2013
  4. ncbi request reprint Analysis of failures and clinical outcome of advanced epithelial ovarian cancer in patients with microscopic residual disease at second-look reassessment following primary cytoreductive surgery and first-line platinum-based chemotherapy
    A Gadducci
    Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa
    Eur J Gynaecol Oncol 34:213-7. 2013
  5. doi request reprint Fertility outcome of breast cancer and Hodgkin's lymphoma female survivors: a growing clinical challenge for gynecologists and oncologists
    Angiolo Gadducci
    Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Gynecol Endocrinol 29:729-34. 2013
  6. doi request reprint Tissue biomarkers as prognostic variables of cervical cancer
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Crit Rev Oncol Hematol 86:104-29. 2013
  7. doi request reprint Prognostic factors and clinical outcome of patients with recurrent early-stage epithelial ovarian cancer: an Italian multicenter retrospective study
    Angiolo Gadducci
    Division of Gynecology and Obstetrics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    Int J Gynecol Cancer 23:461-8. 2013
  8. ncbi request reprint Prognostic value of lymph node status and number of removed nodes in patients with squamous cell carcinoma of the vulva treated with modified radical vulvectomy and inguinal-femoral lymphadenectomy
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Eur J Gynaecol Oncol 33:640-3. 2012
  9. doi request reprint Fertility drug use and risk of ovarian tumors: a debated clinical challenge
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 29:30-5. 2013
  10. doi request reprint New insights on the pathogenesis of ovarian carcinoma: molecular basis and clinical implications
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 28:582-6. 2012

Detail Information

Publications92

  1. doi request reprint Surveillance procedures for patients treated for endometrial cancer: a review of the literature
    Enrico Sartori
    Department of Gynecology and Obstetrics, University of Brescia, Brescia, Italy
    Int J Gynecol Cancer 20:985-92. 2010
    ..The aim of this review was to analyze the role of follow-up in patients treated for endometrial cancer and to provide some compelling issues that may contribute to improve daily practice while waiting for evidence-based guidelines...
  2. doi request reprint Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Crit Rev Oncol Hematol 83:71-83. 2012
    ....
  3. doi request reprint Antiangiogenic agents in advanced, persistent or recurrent endometrial cancer: a novel treatment option
    Angiolo Gadducci
    Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa 56127, Italy
    Gynecol Endocrinol 29:811-6. 2013
    ..Dovitinib, a tyrosine kinase inhibitor targeting both VEGF receptor (VEGFR) and FGFRs, is under clinical investigation in different malignancies including endometrial cancer...
  4. ncbi request reprint Analysis of failures and clinical outcome of advanced epithelial ovarian cancer in patients with microscopic residual disease at second-look reassessment following primary cytoreductive surgery and first-line platinum-based chemotherapy
    A Gadducci
    Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa
    Eur J Gynaecol Oncol 34:213-7. 2013
    ..To assess the pattern of failure and survival of advanced ovarian cancer patients with microscopic residual disease at second-look following cytoreductive surgery and platinum-based chemotherapy...
  5. doi request reprint Fertility outcome of breast cancer and Hodgkin's lymphoma female survivors: a growing clinical challenge for gynecologists and oncologists
    Angiolo Gadducci
    Department of Clinical and Experimental Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Gynecol Endocrinol 29:729-34. 2013
    ....
  6. doi request reprint Tissue biomarkers as prognostic variables of cervical cancer
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Crit Rev Oncol Hematol 86:104-29. 2013
    ..Moreover, the assessment of different types of TIL and their ligands in tumor biopsies could enable the identification of a subset of high-risk patients, paving the way to novel immune therapies aimed at blocking T-reg cell activity...
  7. doi request reprint Prognostic factors and clinical outcome of patients with recurrent early-stage epithelial ovarian cancer: an Italian multicenter retrospective study
    Angiolo Gadducci
    Division of Gynecology and Obstetrics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    Int J Gynecol Cancer 23:461-8. 2013
    ..The objective of this study was to assess the clinical outcome of patients with recurrent early-stage ovarian cancer...
  8. ncbi request reprint Prognostic value of lymph node status and number of removed nodes in patients with squamous cell carcinoma of the vulva treated with modified radical vulvectomy and inguinal-femoral lymphadenectomy
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Eur J Gynaecol Oncol 33:640-3. 2012
    ..To assess the outcome of patients with squamous cell vulvar carcinoma treated with deep partial or total vulvectomy and inguinal-femoral lymphadenectomy...
  9. doi request reprint Fertility drug use and risk of ovarian tumors: a debated clinical challenge
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 29:30-5. 2013
    ....
  10. doi request reprint New insights on the pathogenesis of ovarian carcinoma: molecular basis and clinical implications
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 28:582-6. 2012
    ....
  11. ncbi request reprint Benign breast diseases, contraception and hormone replacement therapy
    A Gadducci
    Department of Procreative Medicine, University of Pisa, Pisa, Italy
    Minerva Ginecol 64:67-74. 2012
    ..The limited available data failed to detect a deleterious effect of HRT use in women with benign breast disease, even in those with increased breast cancer risk due to a family history or high-risk benign breast conditions...
  12. doi request reprint Are surveillance procedures of clinical benefit for patients treated for ovarian cancer?: A retrospective Italian multicentric study
    Angiolo Gadducci
    Department of Procreative Medicine, University of Pisa, Italy
    Int J Gynecol Cancer 19:367-74. 2009
    ....
  13. doi request reprint The perioperative management of patients with gynaecological cancer undergoing major surgery: A debated clinical challenge
    Angiolo Gadducci
    Department of Procreative Medicine, University of Pisa, Italy
    Crit Rev Oncol Hematol 73:126-40. 2010
    ....
  14. doi request reprint Surveillance of patients after initial treatment of ovarian cancer
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Crit Rev Oncol Hematol 71:43-52. 2009
    ..A prospective, randomised trial of therapeutic interventions based on stratification by PET/CT disease status could elucidate the real impact of this diagnostic procedure in the management of patients with recurrent ovarian cancer...
  15. ncbi request reprint Analysis of the pattern of hypersensitivity reactions in patients receiving carboplatin retreatment for recurrent ovarian cancer
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Int J Gynecol Cancer 18:615-20. 2008
    ....
  16. doi request reprint Serum and tissue biomarkers as predictive and prognostic variables in epithelial ovarian cancer
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa 56127, Italy
    Crit Rev Oncol Hematol 69:12-27. 2009
    ..A next future microarray technology will hopefully offer interesting perspectives of translational research for the identification of novel predictive and prognostic biomarkers for epithelial ovarian cancer...
  17. doi request reprint Molecular target therapies in endometrial cancer: from the basic research to the clinic
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 24:239-49. 2008
    ..A better understanding of the signaling transduction pathways that are dysregulated in endometrioid-type endometrial carcinoma and UPSC will allow the development of novel molecular targeted therapies...
  18. ncbi request reprint Clear cell carcinoma of the endometrium: a biological and clinical enigma
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Anticancer Res 30:1327-34. 2010
    ..An adequate molecular characterization of clear cell carcinoma of the endometrium is strongly warranted in order to identify new biological prognostic variables of the disease and to develop novel molecular targeted therapies...
  19. doi request reprint Intraperitoneal chemotherapy in the management of patients with advanced epithelial ovarian cancer: a critical review of the literature
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Int J Gynecol Cancer 18:943-53. 2008
    ....
  20. ncbi request reprint Brain recurrences in patients with ovarian cancer: report of 12 cases and review of the literature
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa 56127, Italy
    Anticancer Res 27:4403-9. 2007
    ..5 months versus > or =33.5 months). In conclusion, brain metastasis from ovarian cancer can represent a late manifestation of the disease, associated with a very poor prognosis...
  21. ncbi request reprint The serum assay of tumour markers in the prognostic evaluation, treatment monitoring and follow-up of patients with cervical cancer: a review of the literature
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa 56127, Italy
    Crit Rev Oncol Hematol 66:10-20. 2008
    ..However, the clinical relevance of serum VEGF assay is still investigational...
  22. ncbi request reprint Ovarian function and childbearing issues in breast cancer survivors
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 23:625-31. 2007
    ..In conclusion, future pregnancy is a viable option for a woman treated for early-stage breast cancer and does not appear to be detrimental to either the mother or her offspring...
  23. ncbi request reprint Biochemical prognostic factors and risk of relapses in patients with cervical cancer
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa, 56127, Italy
    Gynecol Oncol 107:S23-6. 2007
    ..Pre-treatment CA 125 levels appear to have a prognostic value, and rising serum CA 125 may precede or be coincident with the clinical diagnosis of recurrent cervical adenocarcinoma...
  24. ncbi request reprint The management of patients with uterine sarcoma: a debated clinical challenge
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, Pisa, Italy
    Crit Rev Oncol Hematol 65:129-42. 2008
    ..Patients should be encouraged to enter clinical trials designed to identify new active drugs for these malignancies...
  25. ncbi request reprint Intratumoral microvessel density in advanced epithelial ovarian cancer and its use as a prognostic variable
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa, 56127, Italy
    Anticancer Res 26:3925-32. 2006
    ....
  26. ncbi request reprint Lymph-vascular space involvement and outer one-third myometrial invasion are strong predictors of distant haematogeneous failures in patients with stage I-II endometrioid-type endometrial cancer
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa 56127, Italy
    Anticancer Res 29:1715-20. 2009
    ..Patients with these pathological findings should be enrolled in randomised trials designed to assess the role of adjuvant chemotherapy alone or combined with sequential and/or concomitant external pelvic irradiation...
  27. doi request reprint Weekly low-dose paclitaxel as maintenance treatment in patients with advanced ovarian cancer who had microscopic residual disease at second-look surgery after 6 cycles of paclitaxel/platinum-based chemotherapy: results of an open noncomparative phase 2 mu
    Angiolo Gadducci
    Department of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Int J Gynecol Cancer 19:615-9. 2009
    ..0%) cases. The 3-year progression-free survival rate was 18% (95% CI, 9.6%-33.8%), and the 3-year overall survival rate was 64% (95% CI, 52.0%-78.0%). Weekly low-dose paclitaxel is a feasible and well-tolerated maintenance treatment...
  28. ncbi request reprint Patterns of failures in endometrial cancer: clinicopathological variables predictive of the risk of local, distant and retroperitoneal failure
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa 56127, Italy
    Anticancer Res 31:3483-8. 2011
    ..The aim of this study was to assess the pattern of failure and the outcome of endometrial cancer patients and to analyze the variables predictive of the risk of local, distant and retroperitoneal lymph node disease recurrence...
  29. doi request reprint Prognostic factors in uterine sarcoma
    Angiolo Gadducci
    Departmental Unit of Gynecologic Oncology, Department of Procreative Medicine, University of Pisa, Italy
    Best Pract Res Clin Obstet Gynaecol 25:783-95. 2011
    ..Immunomarkers for cell proliferation and apoptosis have been tested for the identification of tumours with different clinical behaviour, but they are still subject to research and are not currently used in clinical practice...
  30. doi request reprint Smoking habit, immune suppression, oral contraceptive use, and hormone replacement therapy use and cervical carcinogenesis: a review of the literature
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 27:597-604. 2011
    ..Experimental data have shown that estradiol and progesterone can modulate the host immune response to HPV16. Prophylactic vaccination in conjunction with cervical screening is the best prevention strategy for cervical cancer...
  31. doi request reprint Tissue and serum biomarkers as prognostic variables in endometrioid-type endometrial cancer
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Crit Rev Oncol Hematol 80:181-92. 2011
    ..Tissue and serum biomarkers could be used, in addition to the conventional clinical-pathological variables, for the stratification of patients into categories with different risk of recurrence to better tailor adjuvant treatment...
  32. doi request reprint Pretreatment platelet and hemoglobin levels are neither predictive nor prognostic variables for patients with locally advanced cervical cancer treated with neoadjuvant chemotherapy and radical hysterectomy: a retrospective Italian study
    Angiolo Gadducci
    Division of Gynecology and Obstetrics, Department of Procreative Medicine, University of Pisa, Via Roma 56, Pisa, Italy
    Int J Gynecol Cancer 20:1399-404. 2010
    ..To assess the predictive and prognostic values of pretreatment platelet and hemoglobin levels in patients with locally advanced cervical cancer who underwent neoadjuvant chemotherapy followed by radical hysterectomy...
  33. ncbi request reprint Pattern of failures and clinical outcome of patients with locally advanced cervical cancer treated with a tailored integrated therapeutic approach
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Anticancer Res 30:3731-5. 2010
    ..To review a tailored treatment with concurrent chemoradiotherapy (CT/RT) or neoadjuvant chemotherapy (NACT) followed by radical hysterectomy in locally advanced cervical cancer...
  34. doi request reprint Gynaecologic challenging issues in the management of BRCA mutation carriers: oral contraceptives, prophylactic salpingo-oophorectomy and hormone replacement therapy
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 26:568-77. 2010
    ..Short-term use of hormone replacement therapy may relieve menopausal symptoms and does not appear to affect the breast cancer risk reduction obtained with salpingo-oophorectomy...
  35. doi request reprint The evolving role of adjuvant therapy in endometrial cancer
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa 56127, Italy
    Crit Rev Oncol Hematol 78:79-91. 2011
    ..Reliable surgical/pathological variables predictive of high risk of distant failure may be used to identify a subset of patients suitable for randomized trials of adjuvant chemotherapy with or without external irradiation...
  36. ncbi request reprint Clinicopathological variables predictive of clinical outcome in patients with FIGO stage Ib2-IIb cervical cancer treated with cisplatin-based neoadjuvant chemotherapy followed by radical hysterectomy
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa, 56127, Italy
    Anticancer Res 30:201-8. 2010
    ..A multivariate analysis on a larger series of homogeneously treated patients is warranted to better define the clinicopathological risk factors useful to adequately plan the therapeutic strategy...
  37. doi request reprint The clinical outcome of epithelial ovarian cancer patients with apparently isolated lymph node recurrence: a multicenter retrospective Italian study
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Oncol 116:358-63. 2010
    ..To assess the clinical outcome of epithelial ovarian cancer patients who developed an apparently isolated lymph node recurrence after primary therapy...
  38. doi request reprint Progestagen component in combined hormone replacement therapy in postmenopausal women and breast cancer risk: a debated clinical issue
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 25:807-15. 2009
    ..Further basic and clinical investigations on this topic are strongly warranted to elucidate whether the choice of the progestagen component in combined HRT could be of clinical relevance as for breast cancer risk...
  39. ncbi request reprint Evolving role of serum biomarkers in the management of ovarian cancer
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa, 56127, Italy
    Womens Health (Lond Engl) 2:141-58. 2006
    ..The future for serum tumor marker research is represented by the emerging technology of proteomics, which may allow scientific advances comparable to those achieved with the introduction of monoclonal antibody technology...
  40. doi request reprint The fertility-sparing treatment in patients with endometrial atypical hyperplasia and early endometrial cancer: a debated therapeutic option
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa 56127, Italy
    Gynecol Endocrinol 25:683-91. 2009
    ..In any case, the patient should be accurately informed about the relatively high recurrence rates after complete response to hormone treatment and expectations for pregnancy...
  41. ncbi request reprint Old and new perspectives in the management of high-risk, locally advanced or recurrent, and metastatic vulvar cancer
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa 56127, Italy
    Crit Rev Oncol Hematol 60:227-41. 2006
    ..The drugs used for chemotherapy of metastatic melanomas or sarcomas of the vulva are the same employed for the melanomas or sarcomas developed in other sites...
  42. ncbi request reprint p53 status is neither a predictive nor a prognostic variable in patients with advanced ovarian cancer treated with a paclitaxel-based regimen
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa, 56127, Italy
    Anticancer Res 20:4793-9. 2000
    ..The aim of this study was to assess the relationship between p53 status and the clinical outcome of patients with advanced ovarian cancer treated with a paclitaxel-based regimen...
  43. ncbi request reprint Chemotherapy with epirubicin and paclitaxel for breast cancer during pregnancy: case report and review of the literature
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 67, 56127 Pisa, Italy
    Anticancer Res 23:5225-9. 2003
    ..Breast cancer diagnosed during pregnancy is a challenging clinical situation. Little data are currently available about chemotherapy in pregnant women with this malignancy...
  44. ncbi request reprint Serum tumor markers in the management of ovarian, endometrial and cervical cancer
    Angiolo Gadducci
    Division of Gynecology and Obstetrics, Department of Procreative Medicine and Child Development, University of Pisa, Via Roma 67, 56127, Pisa, Italy
    Biomed Pharmacother 58:24-38. 2004
    ..Elevated CA 125 levels can be often detected in patients with cervical adenocarcinoma. The future for tumor marker research is represented by the emerging technologies of transcriptional profiling and proteomics...
  45. ncbi request reprint Vascular endothelial growth factor (VEGF) expression in primary tumors and peritoneal metastases from patients with advanced ovarian carcinoma
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 67, 56127 Pisa, Italy
    Anticancer Res 23:3001-8. 2003
    ....
  46. ncbi request reprint Intratumoral microvessel density, response to chemotherapy and clinical outcome of patients with advanced ovarian carcinoma
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 67, 56127 Pisa, Italy
    Anticancer Res 23:549-56. 2003
    ....
  47. ncbi request reprint Surgical cytoreduction during second-look laparotomy in patients with advanced ovarian cancer
    A Gadducci
    Department of Procreative Medicine, University of Pisa, Italy
    Anticancer Res 20:1959-64. 2000
    ..The impact of surgical cytoreduction performed during second-look on the survival of patients with advanced ovarian cancer is still under debate...
  48. ncbi request reprint Treatment options in patients with recurrent ovarian cancer
    A Gadducci
    Department of Procreative Medicine, Pisa, Italy
    Anticancer Res 21:3557-64. 2001
    ..Secondary surgical cytoreduction may have a role in highly selected patients with good performance status, with long disease-free interval and without extra-abdominal or liver metastases...
  49. ncbi request reprint Neoadjuvant chemotherapy and concurrent chemoradiation in the treatment of advanced cervical cancer
    A Gadducci
    Department of Procreative Medicine, University of Pisa, Italy
    Anticancer Res 21:3525-33. 2001
    ..A multicenter randomized trial comparing chemo-surgical treatment with concurrent chemoradiation is warranted to better define the optimum therapeutic strategy for patients with advanced cervical cancer...
  50. ncbi request reprint Current management of fallopian tube carcinoma
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Curr Opin Obstet Gynecol 14:27-32. 2002
    ..Second-line treatment for persistent/recurrent disease should be mainly based on the platinum-free interval, whereas secondary cytoreduction should be considered only for highly selected patients with localized, late relapse...
  51. ncbi request reprint Analysis of failures in patients with FIGO stage IIIc1-IIIc2 endometrial cancer
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa, 56127, Italy
    Anticancer Res 32:201-5. 2012
    ..To assess the pattern of failures in patients with FIGO stage IIIc(1)-IIIc(2) endometrial cancer...
  52. ncbi request reprint Malnutrition and cachexia in ovarian cancer patients: pathophysiology and management
    A Gadducci
    Department of Procreative Medicine, University of Pisa, Italy
    Anticancer Res 21:2941-7. 2001
    ..Krebs' and Goplerud's score (based on age, nutritional status, tumor status, ascites, previous chemotherapy and irradiation) seems to offer reliable eligibility criteria for those patients who can benefit from surgery...
  53. ncbi request reprint The management of malignant nondysgerminomatous ovarian germ cell tumors
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 67, 56127 Pisa, Italy
    Anticancer Res 23:1827-36. 2003
    ..In conclusion, the current therapeutic strategies are able to save the large majority of patients with nondysgerminomatous ovarian germ cell tumors and to preserve their reproductive potential...
  54. ncbi request reprint An intensive follow-up does not change survival of patients with clinical stage I endometrial cancer
    A Gadducci
    Department of Procreative Medicine, University of Pisa, Italy
    Anticancer Res 20:1977-84. 2000
    ..The clinical benefit of an intensive follow-up protocol in endometrial cancer patients is still uncertain...
  55. ncbi request reprint The clinical relevance of serum CYFRA 21-1 assay in patients with ovarian cancer
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Int J Gynecol Cancer 11:277-82. 2001
    ..Moreover, the serial measurement of CYFRA 21-1 levels might have a potential clinical relevance for the assessment of disease status in patients followed after surgery and chemotherapy...
  56. ncbi request reprint Analysis of treatment failures and survival of patients with fallopian tube carcinoma: a cooperation task force (CTF) study
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa, 56127, Italy
    Gynecol Oncol 81:150-9. 2001
    ..The objective of this retrospective multicenter study was to assess the pattern of failures and survival of patients with primary carcinoma of the fallopian tube...
  57. ncbi request reprint The predictive and prognostic value of serum CA 125 half-life during paclitaxel/platinum-based chemotherapy in patients with advanced ovarian carcinoma
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Gynecol Oncol 93:131-6. 2004
    ....
  58. ncbi request reprint Use of estrogen antagonists and aromatase inhibitors in breast cancer and hormonally sensitive tumors of the uterine body
    Angiolo Gadducci
    Department of Procreative Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 57 56127 Pisa, Italy
    Curr Opin Investig Drugs 5:1031-44. 2004
    ....
  59. ncbi request reprint Polycystic ovary syndrome and gynecological cancers: is there a link?
    Angiolo Gadducci
    Department of Procreative Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Gynecol Endocrinol 20:200-8. 2005
    ....
  60. ncbi request reprint Consolidation and maintenance treatments for patients with advanced epithelial ovarian cancer in complete response after first-line chemotherapy: a review of the literature
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa 56127, Italy
    Crit Rev Oncol Hematol 55:153-66. 2005
    ..e. weekly paclitaxel) might assure a better balance between quality of life and anti-tumor activity in patients previously exposed to chemotherapy...
  61. ncbi request reprint Relationship between time interval from primary surgery to the start of taxane- plus platinum-based chemotherapy and clinical outcome of patients with advanced epithelial ovarian cancer: results of a multicenter retrospective Italian study
    Angiolo Gadducci
    Department of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    J Clin Oncol 23:751-8. 2005
    ..To assess whether the interval from primary surgery to the start of taxane- plus platinum-based chemotherapy has any impact on the clinical outcome of advanced ovarian cancer patients...
  62. ncbi request reprint P53 gene status in patients with advanced serous epithelial ovarian cancer in relation to response to paclitaxel- plus platinum-based chemotherapy and long-term clinical outcome
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Anticancer Res 26:687-93. 2006
    ....
  63. ncbi request reprint Old and new perspectives in the pharmacological treatment of advanced or recurrent endometrial cancer: Hormonal therapy, chemotherapy and molecularly targeted therapies
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa 56127, Italy
    Crit Rev Oncol Hematol 58:242-56. 2006
    ..Further investigations addressed to better understand the signal transduction pathways that are disregulated in endometrial carcinogenesis could identify novel biological targets suitable for tailored therapies...
  64. ncbi request reprint Breast cancer and sex steroids: critical review of epidemiological, experimental and clinical investigations on etiopathogenesis, chemoprevention and endocrine treatment of breast cancer
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, 56127 Pisa, Italy
    Gynecol Endocrinol 20:343-60. 2005
    ..New administration routes and novel hormone regimens are currently under evaluation, and these new HRT modalities could have different impact on breast cancer risk because of their metabolic and pharmacodynamic effects...
  65. ncbi request reprint Neutropenic enterocolitis in an advanced epithelial ovarian cancer patient treated with paclitaxel/platinum-based chemotherapy: a case report and review of the literature
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Anticancer Res 25:2509-13. 2005
    ..Literature data show that neutropenic enterocolitis is a rare but severe complication that can occur in cancer patients treated with chemotherapy and especially with taxanes...
  66. ncbi request reprint Pre-chemotherapy hemoglobin levels and survival in patients with advanced epithelial ovarian cancer who received a first-line taxane/platinum-based regimen: results of a multicenter retrospective Italian study
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa, 56127, Italy
    Gynecol Oncol 98:118-23. 2005
    ....
  67. ncbi request reprint Analysis of treatment failures and survival of patients with uterine papillary serous carcinoma: a Cooperation Task Force (CTF) Study
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Int J Gynecol Cancer 22:1355-60. 2012
    ..To assess the pattern of failures and the survival of patients with uterine papillary serous carcinoma (UPSC)...
  68. doi request reprint Dose individualization can minimize nephrotoxicity due to carboplatin therapy in patients with ovarian cancer
    Carlo Donadio
    Department of Internal Medicine, Division of Nephrology, University of Pisa, Pisa, Italy
    Ther Drug Monit 31:63-9. 2009
    ..Dose individualization, using the value of BCMGFR, may minimize nephrotoxicity due to Carbo-Pt therapy...
  69. ncbi request reprint Relationship between interval from surgery to radiotherapy and local recurrence rate in patients with endometrioid-type endometrial cancer: a retrospective mono-institutional Italian study
    Maria Grazia Fabrini
    Department of Oncology, Division of Radiation Oncology, University of Pisa, Via Roma 56, Pisa, 56127, Italy
    Anticancer Res 32:169-73. 2012
    ....
  70. doi request reprint Could different follow-up modalities play a role in the diagnosis of asymptomatic endometrial cancer relapses?: an Italian multicentric retrospective analysis
    Luisa Carrara
    Department of Gynecology and Obstetrics, University of Brescia, Brescia, Italy
    Int J Gynecol Cancer 22:1013-9. 2012
    ..To discuss whether such procedures are feasible and effective to identify asymptomatic recurrences and describe the pattern of relapse detected by procedures...
  71. pmc Extra-nuclear signaling of progesterone receptor to breast cancer cell movement and invasion through the actin cytoskeleton
    Xiao Dong Fu
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    PLoS ONE 3:e2790. 2008
    ..These results provide original mechanistic explanations for the effects of progestins on breast cancer progression and highlight potential targets to treat endocrine-sensitive breast cancers...
  72. pmc Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer
    G Scambia
    Department of Gynecology and Obstetrics, Catholic University, Rome, Italy
    Br J Cancer 71:354-6. 1995
    ..0009). Multivariate analysis revealed that IL-6 positivity has an independent value...
  73. ncbi request reprint Is pretreatment hemoglobin level a predictor of complete response to salvage chemotherapy for recurrent platinum-pretreated ovarian carcinoma?
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Eur J Gynaecol Oncol 24:405-10. 2003
    ....
  74. ncbi request reprint Surveillance procedures for patients treated for epithelial ovarian cancer: a review of the literature
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Via Roma 56, Pisa 56127, Italy
    Int J Gynecol Cancer 17:21-31. 2007
    ....
  75. ncbi request reprint Adjuvant chemotherapy in early stage uterine sarcomas: an open question
    A Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Eur J Gynaecol Oncol 22:352-7. 2001
    ..It is advisable to design international cooperative randomized trials with the aim of defining the role of adjuvant chemotherapy in the treatment of early stage uterine sarcomas...
  76. ncbi request reprint Molecular mechanisms of apoptosis and chemosensitivity to platinum and paclitaxel in ovarian cancer: biological data and clinical implications
    A Gadducci
    Department of Procreative Medicine, University of Pisa, Italy
    Eur J Gynaecol Oncol 23:390-6. 2002
    ..Moreover the understanding of cellular mechanisms regulating apoptosis might offer a strong rationale for the combination of chemotherapy with other biological treatments...
  77. ncbi request reprint The clinical outcome of patients with stage Ia1 and Ia2 squamous cell carcinoma of the uterine cervix: a Cooperation Task Force (CTF) study
    A Gadducci
    Department of Gynecology and Obstetrics, University of Pisa, Italy
    Eur J Gynaecol Oncol 24:513-6. 2003
    ..The objective of this retrospective multicenter study was to assess the clinical outcome of patients with microinvasive squamous cell carcinoma of the uterine cervix...
  78. pmc Evaluation of FHIT gene alterations in ovarian cancer
    F Buttitta
    Department of Oncology, University of Pisa, Italy
    Br J Cancer 77:1048-51. 1998
    ..In none of these cases was the FHITgene found to be altered. Our results indicate that FHITplays a role in a small proportion of ovarian carcinomas...
  79. ncbi request reprint Correlation of recurrence rates and times with posttreatment human papillomavirus status in patients treated with loop electrosurgical excision procedure conization for cervical squamous intraepithelial lesions
    B Prato
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy
    Int J Gynecol Cancer 18:90-4. 2008
    ..The combined evaluation of surgical margin status and posttreatment HPV testing could allow to subdivide patients treated with LEEP into categories at different risk of recurrence, requiring new tailored surveillance procedures...
  80. ncbi request reprint Renal impairment in patients with ovarian cancer
    Carlo Donadio
    Department of Internal Medicine, Division of Nephrology, University of Pisa, I 56100, Pisa, Italy
    Eur J Obstet Gynecol Reprod Biol 106:198-202. 2003
    ..To investigate the prevalence of renal impairment in patients with ovarian cancer at the time of the diagnosis...
  81. ncbi request reprint Controversial issues in climacteric medicine II. Hormone replacement therapy and cancer. International Menopause Society Expert Workshop. 9-12 June 2001, Opera del Duomo, Pisa, Italy
    A R Genazzani
    Department of Gynecology and Obstetrics, University of Pisa, Via Roma 35, 56126 Italy
    Climacteric 4:181-93. 2001
    ..This issue is considered as an important area for future evaluation and research. The International Menopause Society is in the process of drawing up specific recommendations for further research in the field of HRT and cancer...
  82. pmc p53 alterations are predictive of chemoresistance and aggressiveness in ovarian carcinomas: a molecular and immunohistochemical study
    F Buttitta
    Institute of Pathology, University of Pisa, Italy
    Br J Cancer 75:230-5. 1997
    ..Thus, a routine analysis of this gene could have profound implications for the treatment of ovarian cancer...
  83. ncbi request reprint The prognostic relevance of histological type in uterine sarcomas: a Cooperation Task Force (CTF) multivariate analysis of 249 cases
    A Gadducci
    Department of Gynecology and Obstetrics, University of Pisa, Italy
    Eur J Gynaecol Oncol 23:295-9. 2002
    ..The objective of this retrospective multicenter study was to assess the prognostic relevance of histologic type in uterine sarcomas...
  84. ncbi request reprint Sex-steroid hormones, gonadotropin and ovarian carcinogenesis: a review of epidemiological and experimental data
    A Gadducci
    Department of Procreative Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Gynecol Endocrinol 19:216-28. 2004
  85. ncbi request reprint Could follow-up different modalities play a role in asymptomatic cervical cancer relapses diagnosis? An Italian multicenter retrospective analysis
    P Zola
    Department of Gynecology and Obstetrics, University of Turin, Turin, Italy
    Gynecol Oncol 107:S150-4. 2007
    ..The aim of this study was to evaluate how much clinical surveillance performed by follow-up scheduled appointments may correctly identify asymptomatic recurrences and describe the pattern of relapse detected by procedures...
  86. ncbi request reprint Osteosarcoma of the myometrium synchronous with bilateral papillary cystadenocarcinoma of the ovary and papillary adenocarcinoma of the cervix
    F Basolo
    Institute of Pathologic Anatomy and Histology, University of Pisa, Italy
    Tumori 74:227-31. 1988
    ..Clinical and pathological features of previously reported cases of uterine osteosarcoma and triple primary neoplasias of the upper female genital tract are critically reviewed...
  87. ncbi request reprint Preoperative serum vascular endothelial growth factor as a prognostic parameter in ovarian cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, A 1090 Vienna, Wahringer Gurtel, Austria
    Gynecol Oncol 103:512-7. 2006
    ..Serum vascular endothelial growth factor (VEGF) levels have been shown to be associated with an adverse outcome in patients with ovarian cancer. We studied the clinical value of serum VEGF as an independent prognostic parameter...
  88. ncbi request reprint Analysis of the evolution in the management of endometrial cancer in Italy: a CTF study
    Paolo Zola
    Cattedra di Ginecologia Oncologica, Ospedale Mauriziano Umberto 1, Torino, Italy
    Tumori 88:481-8. 2002
    ..In 2001, we mailed again the same questionnaire to the same referral Centers in Italy. The aim of the second enquiry was the evaluation of changes in endometrial cancer management and the effective impact of the guidelines published...
  89. ncbi request reprint Human telomerase reverse transcriptase mRNA expression assessed by real-time reverse transcription polymerase chain reaction predicts chemosensitivity in patients with ovarian carcinoma
    Fiamma Buttitta
    Department of Oncology and Neurosciences, University of Chieti, Italy
    J Clin Oncol 21:1320-5. 2003
    ..To evaluate in vivo whether the expression of the human telomerase reverse transcriptase (hTERT) gene, the catalytic subunit of the telomerase complex, is predictive of response to chemotherapy in ovarian cancer patients...
  90. ncbi request reprint Gynecological malignancies in elderly patients: is age 70 a limit to standard-dose chemotherapy? An Italian retrospective toxicity multicentric study
    Marcello Ceccaroni
    Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy
    Gynecol Oncol 85:445-50. 2002
    ..One hundred and forty-eight consecutive gynecological oncological patients aged >or=70 were administered chemotherapy during the years 1990-2000...
  91. ncbi request reprint Management of borderline ovarian tumors: results of an Italian multicenter study
    Cesare Romagnolo
    Department of Gynecology, Sacro Cuore Hospital, V le Sempreboni, 37024 Negrar Verona, Italy
    Gynecol Oncol 101:255-60. 2006
    ..A rising number of patients affected by ovarian masses suspected of borderline ovarian tumor are operated on primary laparoscopic procedure...
  92. ncbi request reprint Results of the 2006 Innsbruck International Consensus Conference on intraperitoneal chemotherapy in patients with ovarian cancer
    Christian Marth
    Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    Cancer 109:645-9. 2007