S Fustinoni

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint [Epigenic modifications associated with low benzene exposure]
    Silvia Fustinoni
    Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Italy
    G Ital Med Lav Ergon 35:263-7. 2013
  2. doi request reprint High-throughput determination of cortisol, cortisone, and melatonin in oral fluid by on-line turbulent flow liquid chromatography interfaced with liquid chromatography/tandem mass spectrometry
    Silvia Fustinoni
    Department of Clinical Sciences and Community Health, Università degli Studi di Milano and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Rapid Commun Mass Spectrom 27:1450-60. 2013
  3. ncbi request reprint [Air and biomonitoring of occupational exposure to anesthetic gases in the health care workers of a large hospital in Milan]
    S Fustinoni
    Dipartimento di Scienze Cliniche e di Comunità, University degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Via S Barnaba, 8 20122 Milano
    G Ital Med Lav Ergon 34:278-9. 2012
  4. ncbi request reprint [The assessment of risk for xylene exposure in a laboratory of anatomy: comparison between computational models and environmental and biological monitoring]
    S Fustinoni
    Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via S Barnaba, 8 20122 Milano
    G Ital Med Lav Ergon 34:794-5. 2012
  5. ncbi request reprint Global DNA methylation and low-level exposure to benzene
    Silvia Fustinoni
    Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Med Lav 103:84-95. 2012
  6. doi request reprint Environmental and lifestyle factors affect benzene uptake biomonitoring of residents near a petrochemical plant
    Silvia Fustinoni
    Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via S Barnaba, 8 20122 Milan, Italy
    Environ Int 39:2-7. 2012
  7. pmc Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers
    Mirjam Hoxha
    Center of Molecular and Genetic Epidemiology, Department of Preventive Medicine, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Environ Health 8:41. 2009
  8. ncbi request reprint [Validity of carbohydrate-deficient transferrine (CDT) in assessing chronic abuse of ethyl alcohol in urban public transport workers]
    Silvia Fustinoni
    Unitá Operativa di Epidemiologia, Dipartimento di Medicina Preventiva, del Lavoro e dell Ambiente Clinica del Lavoro L Devoto, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena e Università degli Studi di Milano, Milano, Italy
    Med Lav 100:359-69. 2009
  9. doi request reprint Methodological issues in the biological monitoring of urinary benzene and S-phenylmercapturic acid at low exposure levels
    Silvia Fustinoni
    Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8 20122 Milan, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 878:2534-40. 2010
  10. doi request reprint Assessing variability and comparing short-term biomarkers of styrene exposure using a repeated measurements approach
    S Fustinoni
    Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8 20122 Milan, Italy
    Toxicol Lett 192:40-4. 2010

Collaborators

Detail Information

Publications55

  1. ncbi request reprint [Epigenic modifications associated with low benzene exposure]
    Silvia Fustinoni
    Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano, Italy
    G Ital Med Lav Ergon 35:263-7. 2013
    ..Our studies highlighted the association of epigenetic modifications of DNA with low benzene exposure...
  2. doi request reprint High-throughput determination of cortisol, cortisone, and melatonin in oral fluid by on-line turbulent flow liquid chromatography interfaced with liquid chromatography/tandem mass spectrometry
    Silvia Fustinoni
    Department of Clinical Sciences and Community Health, Università degli Studi di Milano and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Rapid Commun Mass Spectrom 27:1450-60. 2013
    ..The aim of this study was to develop and evaluate a high-throughput assay for the detection of CORTol, CORTone, and MELA concentrations in non-invasively collected oral fluid samples...
  3. ncbi request reprint [Air and biomonitoring of occupational exposure to anesthetic gases in the health care workers of a large hospital in Milan]
    S Fustinoni
    Dipartimento di Scienze Cliniche e di Comunità, University degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Via S Barnaba, 8 20122 Milano
    G Ital Med Lav Ergon 34:278-9. 2012
    ..The results of this study indicates that further efforts are needed to improve the hygienic conditions in the investigated hospital...
  4. ncbi request reprint [The assessment of risk for xylene exposure in a laboratory of anatomy: comparison between computational models and environmental and biological monitoring]
    S Fustinoni
    Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via S Barnaba, 8 20122 Milano
    G Ital Med Lav Ergon 34:794-5. 2012
    ..These ratings are consistent with those obtained using the experimental approach. This result, combined with the simplicity and low cost, makes the algorithms very interesting tools for the assessment of chemical risk in the workplace...
  5. ncbi request reprint Global DNA methylation and low-level exposure to benzene
    Silvia Fustinoni
    Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Med Lav 103:84-95. 2012
    ..Whether global genomic DNA methylation content is reduced in response to benzene exposure is still undetermined...
  6. doi request reprint Environmental and lifestyle factors affect benzene uptake biomonitoring of residents near a petrochemical plant
    Silvia Fustinoni
    Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via S Barnaba, 8 20122 Milan, Italy
    Environ Int 39:2-7. 2012
    ..We monitored urinary benzene excretion to examine factors affecting benzene uptake in a sample of the general population living near a petrochemical plant...
  7. pmc Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers
    Mirjam Hoxha
    Center of Molecular and Genetic Epidemiology, Department of Preventive Medicine, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Environ Health 8:41. 2009
    ..Traffic pollution has been linked with both cardiovascular and cancer risks, particularly in older subjects. Whether exposure to traffic pollution is associated with telomere shortening has never been evaluated...
  8. ncbi request reprint [Validity of carbohydrate-deficient transferrine (CDT) in assessing chronic abuse of ethyl alcohol in urban public transport workers]
    Silvia Fustinoni
    Unitá Operativa di Epidemiologia, Dipartimento di Medicina Preventiva, del Lavoro e dell Ambiente Clinica del Lavoro L Devoto, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena e Università degli Studi di Milano, Milano, Italy
    Med Lav 100:359-69. 2009
    ..The aim of this study was to verify the ability of some chemical-clinical parameters, with particular emphasis on carbohydrate-deficient transferrin (CDT), in assessing chronic abuse of ethanol in a group of urban public transport workers...
  9. doi request reprint Methodological issues in the biological monitoring of urinary benzene and S-phenylmercapturic acid at low exposure levels
    Silvia Fustinoni
    Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8 20122 Milan, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 878:2534-40. 2010
    ..However, the determination of SPMA concentrations at levels close to the limit of quantification was less reliable...
  10. doi request reprint Assessing variability and comparing short-term biomarkers of styrene exposure using a repeated measurements approach
    S Fustinoni
    Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8 20122 Milan, Italy
    Toxicol Lett 192:40-4. 2010
    ..178 and 0.210 for MA in the same groups, our results suggest that either air measurements or conventional biomarker measurements (urinary MA) would be comparable surrogates for individual exposures in epidemiologic studies...
  11. ncbi request reprint Comparison between urinary o-cresol and toluene as biomarkers of toluene exposure
    Silvia Fustinoni
    Department of Occupational and Environmental Medicine, University of Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Occup Environ Hyg 4:1-9. 2007
    ..Therefore TOL-U may be considered superior to o-C as a biomarker of occupational exposure to toluene...
  12. doi request reprint Dermal exposure to polycyclic aromatic hydrocarbons in asphalt workers
    Silvia Fustinoni
    Dipartimento di Medicina del Lavoro, Università degli Studi di Milano e Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Occup Environ Med 67:456-63. 2010
    ....
  13. doi request reprint Self-collected urine sampling to study the kinetics of urinary toluene (and o-cresol) and define the best sampling time for biomonitoring
    Silvia Fustinoni
    Department of Occupational and Environmental Medicine, University of Milano, Milan, Italy
    Int Arch Occup Environ Health 82:703-13. 2009
    ....
  14. doi request reprint Biological monitoring and questionnaire for assessing exposure to ethylenebisdithiocarbamates in a multicenter European field study
    S Fustinoni
    Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Hum Exp Toxicol 27:681-91. 2008
    ..Although the analysis of self-administered questionnaires evidenced difficulties especially related to lack and/or poor quality of reported data, biological monitoring confirms to be a powerful tool in assessing pesticide exposure...
  15. doi request reprint An integrated approach to biomonitoring exposure to styrene and styrene-(7,8)-oxide using a repeated measurements sampling design
    S Fustinoni
    Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Biomarkers 13:560-78. 2008
    ..Levels of the protein adducts were not associated with exposure to either Sty or StyOX among exposed subjects...
  16. ncbi request reprint Urinary t,t-muconic acid, S-phenylmercapturic acid and benzene as biomarkers of low benzene exposure
    Silvia Fustinoni
    Department of Occupational and Environmental Health, University of Milan and Fondazione Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8, 20122 Milan, Italy
    Chem Biol Interact 153:253-6. 2005
    ..15 ppm), the smoking habit may be regarded as a major source of benzene intake; among the study indices, U-benzene is the marker of choice for the biological monitoring of occupational and environmental exposure...
  17. ncbi request reprint [Biological monitoring in the molding of plastics and rubbers]
    S Fustinoni
    Clinica del Lavoro, Università degli Studi di Milano e Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano
    G Ital Med Lav Ergon 29:284-6. 2007
    ..The levels of these indicators were similar to those measured in other groups of subjects without occupational exposure to PAH, confirming a low airborne contamination in this workplace...
  18. ncbi request reprint Comparison between blood and urinary toluene as biomarkers of exposure to toluene
    S Fustinoni
    Istituti Clinici di Perfezionamento, Milan, Italy
    Int Arch Occup Environ Health 73:389-96. 2000
    ..To compare blood toluene (TOL-B) and urinary toluene (TOL-U) as biomarkers of occupational exposure to toluene, and to set a suitable procedure for collection and handling of specimens...
  19. ncbi request reprint Influence of metabolic genotypes on biomarkers of exposure to 1,3-butadiene in humans
    Silvia Fustinoni
    Dipartimento di Medicina del Lavoro, Istituti Clinici di Perfezionamento, Milano, Italy 20122
    Cancer Epidemiol Biomarkers Prev 11:1082-90. 2002
    ..698). Our results indicate that the THBVal level is influenced by genotypes, and that the analysis of combined polymorphisms may be the key to a better understanding of the role played by polymorphism of BD-metabolizing enzymes...
  20. ncbi request reprint Biological monitoring in occupational exposure to low levels of 1,3-butadiene
    S Fustinoni
    Department of Occupational and Environmental Health, University of Milan and ICP, Via S Barnaba, 8 20122 Milan, Italy
    Toxicol Lett 149:353-60. 2004
    ..Our results show that unmetabolised BD in biological fluids, and particularly urinary BD, represents the biomarker of choice for assessing occupational exposure to low airborne concentrations of BD...
  21. ncbi request reprint Application of gas chromatography-mass spectrometry for the determination of urinary ethylenethiourea in humans
    Silvia Fustinoni
    Department of Occupational and Environmental Health, University of Milano and Istituti Clinici di Perfezionamento, Via S Barnaba, 8 20122 Milano, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 814:251-8. 2005
    ..The procedure was successfully applied to the biological monitoring of vineyard workers exposed to EBDTC and of a matched group of subjects from the general population...
  22. ncbi request reprint Determination of urinary ortho- and meta-cresol in humans by headspace SPME gas chromatography/mass spectrometry
    Silvia Fustinoni
    Department of Occupational and Environmental Medicine, University of Milano and Istituti Clinici di Perfezionamento, Via S Barnaba, 8 20122 Milano, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 817:309-17. 2005
    ..006 mg/l for o-C and 0.007 mg/l for m-C. The procedure is applied to the quantification of cresols in urine from workers exposed to toluene and from subjects belonging to the general population...
  23. doi request reprint A quantitative approach to evaluate urinary benzene and S-phenylmercapturic acid as biomarkers of low benzene exposure
    Silvia Fustinoni
    University of Milan, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Department of Occupational and Environmental Medicine, Milano, Italy
    Biomarkers 16:334-45. 2011
    ..Benzene is a ubiquitous pollutant; smoking habit, genetic polymorphisms, and analytical difficulties impact the identification of the best biomarker...
  24. doi request reprint Urinary BTEX, MTBE and naphthalene as biomarkers to gain environmental exposure profiles of the general population
    Silvia Fustinoni
    Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via S Barnaba, 8 20122 Milan, Italy
    Sci Total Environ 408:2840-9. 2010
    ..The possibility of obtaining urinary exposure profiles makes this method an appealing tool for environmental epidemiology...
  25. ncbi request reprint Monitoring low benzene exposure: comparative evaluation of urinary biomarkers, influence of cigarette smoking, and genetic polymorphisms
    Silvia Fustinoni
    Department of Occupational and Environmental Health, University of Milan, Italy
    Cancer Epidemiol Biomarkers Prev 14:2237-44. 2005
    ..15 ppm), smoking may be regarded as the major source of benzene intake; among the study indices, U-benzene is the marker of choice for biomonitoring low-level occupational and environmental benzene exposure...
  26. ncbi request reprint Urinary hydroxylated metabolites of polycyclic aromatic hydrocarbons as biomarkers of exposure in asphalt workers
    M Buratti
    Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, Milan, Italy
    Biomarkers 12:221-39. 2007
    ..Fumes and vapours released during laying of hot asphalt mix have been recognised as a major source of exposure for asphalt workers...
  27. ncbi request reprint [Urinary MTBE as biological marker of exposure to traffic exhaust fumes]
    L Scibetta
    Dipartimento di Medicina Lavoro, Università degli Studi di Milano e Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano
    G Ital Med Lav Ergon 27:315-7. 2005
    ..Smoking did not affect the excretion of U-MTBE. The results of this study suggest that U-MTBE is a sensitive and specific marker for the assessment of exposure to traffic exhaust fumes...
  28. ncbi request reprint Assessment through environmental and biological measurements of total daily exposure to volatile organic compounds of office workers in Milan, Italy
    P Carrer
    Department of Occupational Health, Istituti Clinici di Perfezionamento, Milan, Italy
    Indoor Air 10:258-68. 2000
    ....
  29. ncbi request reprint [Assessment of exposure to organic aromatic compounds and PAH in asphalt industry: the PPTP-POPA Study results]
    P E Cirla
    Universita degli Studi di Milano, Dipartimento di Medicina del Lavoro, Milano
    G Ital Med Lav Ergon 27:303-7. 2005
    ..The results show that the dermal contamination in road pavers is higher than in ground construction operators and that cutaneous dose rate is higher than respiratory dose rate, whereas the amount of absorption the ratio is inverted...
  30. ncbi request reprint Headspace solid-phase microextraction for the determination of benzene, toluene, ethylbenzene and xylenes in urine
    S Fustinoni
    Istituti Clinici di Perfezionamento, Milan, Italy
    J Chromatogr B Biomed Sci Appl 723:105-15. 1999
    ..The assay has been successfully applied to the biological monitoring of two subjects environmentally exposed to airborne BTEX in an urban area...
  31. ncbi request reprint [Exposure to polycyclic aromatic hydrocarbons (PAH) in rubber forming industry]
    P E Cirla
    Università degli Studi di Milano e Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena IRCCS, Dipartimento di Medicina del Lavoro, Milano
    G Ital Med Lav Ergon 29:282-4. 2007
    ....
  32. doi request reprint Urinary polycyclic aromatic hydrocarbons and monohydroxy metabolites as biomarkers of exposure in coke oven workers
    F Rossella
    Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8 20122 Milan, Italy
    Occup Environ Med 66:509-16. 2009
    ..To assess exposure to polycyclic aromatic hydrocarbons (PAHs) using 13 unmetabolised PAHs (U-PAHs) and 12 monohydroxy metabolites (OHPAHs) in urine, and to compare the utility of these biomarkers...
  33. ncbi request reprint [Plastic industry and exposure to carcinogenic chemical agents: an Italian Multicentric Study in Lombardy]
    P E Cirla
    Università degli Studi di Milano e Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena IRCCS, Dipartimento di Medicina del Lavoro, Milano
    G Ital Med Lav Ergon 29:319-21. 2007
    ....
  34. ncbi request reprint [Environmental and biological monitoring of exposure to PAHs in Taranto coke-oven workers and in two groups of the general population from Apulia]
    L Campo
    Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via San Barnaba 8, 20122 Milano
    G Ital Med Lav Ergon 34:655-7. 2012
    ..3 microg/g crt) in about 90% of NC and FC. The exposure resulted lower than in the past, but this study highlights that PAHs exposure from the coke plant still poses a health risk for workers and the general population...
  35. ncbi request reprint Immunomodulatory effects of the fungicide Mancozeb in agricultural workers
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Toxicol Appl Pharmacol 208:178-85. 2005
    ....
  36. ncbi request reprint [Time course of excretion of tebuconazole and its metabolites in vineyard workers]
    S Fustinoni
    Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via S Barnaba, 8 20122 Milano, Italia
    G Ital Med Lav Ergon 34:423-4. 2012
    ..TEB-COOH has similar pattern. TEB-OH and TEB -COOH are promising candidates for biological monitoring of TEB exposure; preliminary results suggest the day after the application as the best sampling time...
  37. ncbi request reprint Determination of monobromobimane derivatives of phenylmercapturic and benzylmercapturic acids in urine by high-performance liquid chromatography and fluorimetry
    M Buratti
    Istituti Clinici di Perfezionamento, Laboratorio di Tossicologia Professionale, Milan, Italy
    J Chromatogr B Biomed Sci Appl 751:305-13. 2001
    ..69, P<0.01, n=17). The proposed analytical method appears to be a sensitive and specific tool for biological monitoring of low-level exposure to benzene and toluene mixtures in occupational and environmental toxicology laboratory...
  38. ncbi request reprint Application of ultraviolet spectrophotometry to estimate occupational exposure to airborne polyaromatic compounds in asphalt pavers
    Marina Buratti
    Department of Occupational and Environmental Health, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena and University of Milan, Italy
    J Occup Environ Hyg 4:412-9. 2007
    ....
  39. doi request reprint The role of salivary cortisol measured by liquid chromatography-tandem mass spectrometry in the diagnosis of subclinical hypercortisolism
    S Palmieri
    Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Eur J Endocrinol 168:289-96. 2013
    ..The aim of this study was to evaluate the diagnostic accuracy of LNSalC measured by LC-MS/MS in SH...
  40. ncbi request reprint [Occupational exposure to fungicides in floriculture in Ecuador]
    C Colosio
    International Centre for Pesticides and Health Risk Prevention, Ospedale Universitario Luigi Sacco, Milan, Italy
    G Ital Med Lav Ergon 25:107-8. 2003
    ..Higher level ETU excretion was observed in greenhouse compared to open field workers...
  41. ncbi request reprint Assay of urinary alpha-fluoro-beta-alanine by gas chromatography-mass spectrometry for the biological monitoring of occupational exposure to 5-fluorouracil in oncology nurses and pharmacy technicians
    Federico Maria Rubino
    Department of Occupational Medicine, Clinica del Lavoro L Devoto, Università degli Studi di Milano at Ospedale San Paolo, Italy
    Biomed Chromatogr 20:257-66. 2006
    ..On a total number of 65 analyzed urine samples from control and exposed subjects, only three, obtained from exposed subjects, were found to be positive, with values of 20, 30 and 1150 ng/mL, respectively...
  42. ncbi request reprint Biological monitoring of exposure to polycyclic aromatic hydrocarbons by determination of unmetabolized compounds in urine
    Laura Campo
    Department of Occupational and Environmental Health, University of Milan and Fondazione Ospedale Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8 20122 Milan, Italy
    Toxicol Lett 162:132-8. 2006
    ..05). Moreover in RP samples the urinary excretion of most analytes increased during the work shift (p<0.05). These results suggest that urinary PAHs may be useful biomarkers of occupational exposure...
  43. doi request reprint Development of a gas chromatography/mass spectrometry method to quantify several urinary monohydroxy metabolites of polycyclic aromatic hydrocarbons in occupationally exposed subjects
    Laura Campo
    Department of Occupational and Environmental Health, University of Milan, Milan, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 875:531-40. 2008
    ..4 and 69.7 microg/l, respectively), while 6-hydroxychrysene, and 3-hydroxybenzo[a]pyrene were always below the quantification limit...
  44. ncbi request reprint Evaluation of exposure to PAHs in asphalt workers by environmental and biological monitoring
    Laura Campo
    Dept of Occupational and Environmental Health, University of Milan, Fondazione Ospendale Maggiore Policlinico, Mangiagalli e Regina Elena, 8 20122 Milano, Italy
    Ann N Y Acad Sci 1076:405-20. 2006
    ..The contribution of working activities to internal dose was in the same order of magnitude of the contribution of cigarette smoking...
  45. ncbi request reprint Changes in serum markers indicative of health effects in vineyard workers following exposure to the fungicide mancozeb: an Italian study
    Claudio Colosio
    Department of Occupational and Environmental Health of the University of Milan, S Paolo Hospital Unit, Milan, Italy
    Biomarkers 12:574-88. 2007
    ..Altogether the differences between exposed and controls were not consistently correlated to any clinical impairment and suggest that the seasonal application of mancozeb does not pose a significant health risk to exposed subjects...
  46. ncbi request reprint Changes in DNA methylation patterns in subjects exposed to low-dose benzene
    Valentina Bollati
    Molecular Epidemiology Laboratory, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, 20122 Milan, Italy
    Cancer Res 67:876-80. 2007
    ..20). This is the first human study to link altered DNA methylation, reproducing the aberrant epigenetic patterns found in malignant cells, to low-level carcinogen exposure...
  47. ncbi request reprint [Identification of biomarkers of short- and medium-term exposure in urine and hair of subjects exposed to terbuthylazine]
    R Mercadante
    Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via S Barnaba, 8 20122 Milano, Italia
    G Ital Med Lav Ergon 34:418-9. 2012
    ..These results suggest that TBA in hair can be used as an index of cumulative exposure to TBA, while DET in the urine can be used as an index of short-term exposure in farmers...
  48. ncbi request reprint Urinary profiles to assess polycyclic aromatic hydrocarbons exposure in coke-oven workers
    Laura Campo
    Department of Occupational and Environmental Health, University of Milan and Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba 8, 20122 Milan, Italy
    Toxicol Lett 192:72-8. 2010
    ..Moreover, the simultaneous determination of several biomarkers permits to obtain specific excretion profiles that might help in exposure characterization and in better defining the excretion patterns...
  49. doi request reprint Quantification of 13 priority polycyclic aromatic hydrocarbons in human urine by headspace solid-phase microextraction gas chromatography-isotope dilution mass spectrometry
    Laura Campo
    Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Anal Chim Acta 631:196-205. 2009
    ..28-2.28 x 10(1)ngL(-1) range. An application of the proposed method using 15 urine samples from subjects exposed to PAHs at different environmental levels is shown...
  50. doi request reprint Development and validation of a gas chromatography/mass spectrometry method for the assessment of genomic DNA methylation
    Federica Rossella
    Department of Occupational and Environmental Medicine, University of Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8, 20122 Milan, Italy
    Rapid Commun Mass Spectrom 23:2637-46. 2009
    ..05%), DNA from peripheral blood leukocytes of healthy subjects (N = 6, median methylation 5.45%), DNA from bone marrow of leukemia patients (N = 5, 3.58%) and DNA from myeloma cell lines (N = 4, 2.74%)...
  51. ncbi request reprint Determination of low level methyl tert-butyl ether, ethyl tert-butyl ether and methyl tert-amyl ether in human urine by HS-SPME gas chromatography/mass spectrometry
    Licia Scibetta
    Department of Occupational and Environmental Medicine, University of Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8 20122 Milano, Italy
    Anal Chim Acta 581:53-62. 2007
    ....
  52. ncbi request reprint The use of S-phenylmercapturic acid as a biomarker in molecular epidemiology studies of benzene
    Peter B Farmer
    Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, University Road, Leicester LE1 7RH, UK
    Chem Biol Interact 153:97-102. 2005
    ..55 ppm) benzene). All three biomarkers were positively correlated with smoking as measured by urinary cotinine)...
  53. ncbi request reprint Lack of genotoxic effect in workers exposed to very low doses of 1,3-butadiene
    Piero Lovreglio
    Department of Internal Medicine and Public Medicine, Section of Occupational Medicine, University of Bari, Piazza G Cesare 11, 70124 Bari, Italy
    Arch Toxicol 80:378-81. 2006
    ....
  54. ncbi request reprint Reference values for ethylenethiourea in urine in Northern Italy: results of a pilot study
    Claudio Colosio
    International Centre for Pesticides and Health Risk Prevention of the Azienda Ospedaliera Luigi Sacco Polo Universitario, Via GB Grassi 74, 20157 Milan, Italy
    Toxicol Lett 162:153-7. 2006
    ..5-5.0 microg/g creatinine. These values can be used as reference, to compare the results of biological monitoring activities carried out on EBDCs occupationally and environmentally exposed populations...
  55. ncbi request reprint [From industrial hygiene and toxicology to environmental hygiene and toxicology: problems and prospects]
    P Carrer
    Dipartimento di Medicina del Lavoro, Universita degli Studi di Milano
    Med Lav 94:64-8. 2003
    ..The presence in the population (working and general) of groups of susceptible individuals is an important public health issue that poses new challenges to science and society...