Research Topics
Genomes and GenesSpecies | S FustinoniSummaryAffiliation: University of Milan Country: Italy Publications
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Detail Information
Publications
[The assessment of risk for xylene exposure in a laboratory of anatomy: comparison between computational models and environmental and biological monitoring]S Fustinoni
Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via S Barnaba, 8 20122 Milano
G Ital Med Lav Ergon 34:794-5. 2012..These ratings are consistent with those obtained using the experimental approach. This result, combined with the simplicity and low cost, makes the algorithms very interesting tools for the assessment of chemical risk in the workplace...- [Air and biomonitoring of occupational exposure to anesthetic gases in the health care workers of a large hospital in Milan]S Fustinoni
Dipartimento di Scienze Cliniche e di Comunità, University degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Via S Barnaba, 8 20122 Milano
G Ital Med Lav Ergon 34:278-9. 2012..The results of this study indicates that further efforts are needed to improve the hygienic conditions in the investigated hospital... - Global DNA methylation and low-level exposure to benzeneSilvia Fustinoni
Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
Med Lav 103:84-95. 2012..Whether global genomic DNA methylation content is reduced in response to benzene exposure is still undetermined... 
Environmental and lifestyle factors affect benzene uptake biomonitoring of residents near a petrochemical plantSilvia Fustinoni
Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via S Barnaba, 8 20122 Milan, Italy
Environ Int 39:2-7. 2012..We monitored urinary benzene excretion to examine factors affecting benzene uptake in a sample of the general population living near a petrochemical plant...
Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workersMirjam Hoxha
Center of Molecular and Genetic Epidemiology, Department of Preventive Medicine, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
Environ Health 8:41. 2009..Traffic pollution has been linked with both cardiovascular and cancer risks, particularly in older subjects. Whether exposure to traffic pollution is associated with telomere shortening has never been evaluated...- [Validity of carbohydrate-deficient transferrine (CDT) in assessing chronic abuse of ethyl alcohol in urban public transport workers]Silvia Fustinoni
Unitá Operativa di Epidemiologia, Dipartimento di Medicina Preventiva, del Lavoro e dell Ambiente Clinica del Lavoro L Devoto, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena e Università degli Studi di Milano, Milano, Italy
Med Lav 100:359-69. 2009..The aim of this study was to verify the ability of some chemical-clinical parameters, with particular emphasis on carbohydrate-deficient transferrin (CDT), in assessing chronic abuse of ethanol in a group of urban public transport workers... - Dermal exposure to polycyclic aromatic hydrocarbons in asphalt workersSilvia Fustinoni
Dipartimento di Medicina del Lavoro, Università degli Studi di Milano e Fondazione IRCCS, Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
Occup Environ Med 67:456-63. 2010.... - Biological monitoring and questionnaire for assessing exposure to ethylenebisdithiocarbamates in a multicenter European field studyS Fustinoni
Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
Hum Exp Toxicol 27:681-91. 2008..Although the analysis of self-administered questionnaires evidenced difficulties especially related to lack and/or poor quality of reported data, biological monitoring confirms to be a powerful tool in assessing pesticide exposure... - Urinary t,t-muconic acid, S-phenylmercapturic acid and benzene as biomarkers of low benzene exposureSilvia Fustinoni
Department of Occupational and Environmental Health, University of Milan and Fondazione Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8, 20122 Milan, Italy
Chem Biol Interact 153:253-6. 2005..15 ppm), the smoking habit may be regarded as a major source of benzene intake; among the study indices, U-benzene is the marker of choice for the biological monitoring of occupational and environmental exposure... - Comparison between urinary o-cresol and toluene as biomarkers of toluene exposureSilvia Fustinoni
Department of Occupational and Environmental Medicine, University of Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy
J Occup Environ Hyg 4:1-9. 2007..Therefore TOL-U may be considered superior to o-C as a biomarker of occupational exposure to toluene... - Self-collected urine sampling to study the kinetics of urinary toluene (and o-cresol) and define the best sampling time for biomonitoringSilvia Fustinoni
Department of Occupational and Environmental Medicine, University of Milano, Milan, Italy
Int Arch Occup Environ Health 82:703-13. 2009.... - An integrated approach to biomonitoring exposure to styrene and styrene-(7,8)-oxide using a repeated measurements sampling designS Fustinoni
Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
Biomarkers 13:560-78. 2008..Levels of the protein adducts were not associated with exposure to either Sty or StyOX among exposed subjects... - Monitoring low benzene exposure: comparative evaluation of urinary biomarkers, influence of cigarette smoking, and genetic polymorphismsSilvia Fustinoni
Department of Occupational and Environmental Health, University of Milan, Italy
Cancer Epidemiol Biomarkers Prev 14:2237-44. 2005..15 ppm), smoking may be regarded as the major source of benzene intake; among the study indices, U-benzene is the marker of choice for biomonitoring low-level occupational and environmental benzene exposure... - Assessing variability and comparing short-term biomarkers of styrene exposure using a repeated measurements approachS Fustinoni
Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8 20122 Milan, Italy
Toxicol Lett 192:40-4. 2010..178 and 0.210 for MA in the same groups, our results suggest that either air measurements or conventional biomarker measurements (urinary MA) would be comparable surrogates for individual exposures in epidemiologic studies... - Urinary BTEX, MTBE and naphthalene as biomarkers to gain environmental exposure profiles of the general populationSilvia Fustinoni
Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via S Barnaba, 8 20122 Milan, Italy
Sci Total Environ 408:2840-9. 2010..The possibility of obtaining urinary exposure profiles makes this method an appealing tool for environmental epidemiology... - Comparison between blood and urinary toluene as biomarkers of exposure to tolueneS Fustinoni
Istituti Clinici di Perfezionamento, Milan, Italy
Int Arch Occup Environ Health 73:389-96. 2000..To compare blood toluene (TOL-B) and urinary toluene (TOL-U) as biomarkers of occupational exposure to toluene, and to set a suitable procedure for collection and handling of specimens... - Methodological issues in the biological monitoring of urinary benzene and S-phenylmercapturic acid at low exposure levelsSilvia Fustinoni
Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8 20122 Milan, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 878:2534-40. 2010..However, the determination of SPMA concentrations at levels close to the limit of quantification was less reliable... - Influence of metabolic genotypes on biomarkers of exposure to 1,3-butadiene in humansSilvia Fustinoni
Dipartimento di Medicina del Lavoro, Istituti Clinici di Perfezionamento, Milano, Italy 20122
Cancer Epidemiol Biomarkers Prev 11:1082-90. 2002..698). Our results indicate that the THBVal level is influenced by genotypes, and that the analysis of combined polymorphisms may be the key to a better understanding of the role played by polymorphism of BD-metabolizing enzymes... - Biological monitoring in occupational exposure to low levels of 1,3-butadieneS Fustinoni
Department of Occupational and Environmental Health, University of Milan and ICP, Via S Barnaba, 8 20122 Milan, Italy
Toxicol Lett 149:353-60. 2004..Our results show that unmetabolised BD in biological fluids, and particularly urinary BD, represents the biomarker of choice for assessing occupational exposure to low airborne concentrations of BD... - Application of gas chromatography-mass spectrometry for the determination of urinary ethylenethiourea in humansSilvia Fustinoni
Department of Occupational and Environmental Health, University of Milano and Istituti Clinici di Perfezionamento, Via S Barnaba, 8 20122 Milano, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 814:251-8. 2005..The procedure was successfully applied to the biological monitoring of vineyard workers exposed to EBDTC and of a matched group of subjects from the general population... - Determination of urinary ortho- and meta-cresol in humans by headspace SPME gas chromatography/mass spectrometrySilvia Fustinoni
Department of Occupational and Environmental Medicine, University of Milano and Istituti Clinici di Perfezionamento, Via S Barnaba, 8 20122 Milano, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 817:309-17. 2005..006 mg/l for o-C and 0.007 mg/l for m-C. The procedure is applied to the quantification of cresols in urine from workers exposed to toluene and from subjects belonging to the general population... - A quantitative approach to evaluate urinary benzene and S-phenylmercapturic acid as biomarkers of low benzene exposureSilvia Fustinoni
University of Milan, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Department of Occupational and Environmental Medicine, Milano, Italy
Biomarkers 16:334-45. 2011..Benzene is a ubiquitous pollutant; smoking habit, genetic polymorphisms, and analytical difficulties impact the identification of the best biomarker... - [Biological monitoring in the molding of plastics and rubbers]S Fustinoni
Clinica del Lavoro, Università degli Studi di Milano e Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milano
G Ital Med Lav Ergon 29:284-6. 2007..The levels of these indicators were similar to those measured in other groups of subjects without occupational exposure to PAH, confirming a low airborne contamination in this workplace... - Urinary hydroxylated metabolites of polycyclic aromatic hydrocarbons as biomarkers of exposure in asphalt workersM Buratti
Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, Milan, Italy
Biomarkers 12:221-39. 2007..Fumes and vapours released during laying of hot asphalt mix have been recognised as a major source of exposure for asphalt workers... - [Urinary MTBE as biological marker of exposure to traffic exhaust fumes]L Scibetta
Dipartimento di Medicina Lavoro, , Mangiagalli e Regina Elena, Milano
G Ital Med Lav Ergon 27:315-7. 2005..Smoking did not affect the excretion of U-MTBE. The results of this study suggest that U-MTBE is a sensitive and specific marker for the assessment of exposure to traffic exhaust fumes... - Assessment through environmental and biological measurements of total daily exposure to volatile organic compounds of office workers in Milan, ItalyP Carrer
Department of Occupational Health, Istituti Clinici di Perfezionamento, Milan, Italy
Indoor Air 10:258-68. 2000.... - [Assessment of exposure to organic aromatic compounds and PAH in asphalt industry: the PPTP-POPA Study results]P E Cirla
Universita degli Studi di Milano, Dipartimento di Medicina del Lavoro, Milano
G Ital Med Lav Ergon 27:303-7. 2005..The results show that the dermal contamination in road pavers is higher than in ground construction operators and that cutaneous dose rate is higher than respiratory dose rate, whereas the amount of absorption the ratio is inverted... - Headspace solid-phase microextraction for the determination of benzene, toluene, ethylbenzene and xylenes in urineS Fustinoni
Istituti Clinici di Perfezionamento, Milan, Italy
J Chromatogr B Biomed Sci Appl 723:105-15. 1999..The assay has been successfully applied to the biological monitoring of two subjects environmentally exposed to airborne BTEX in an urban area... - [Exposure to polycyclic aromatic hydrocarbons (PAH) in rubber forming industry]P E Cirla
Università degli Studi di Milano e Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena IRCCS, Dipartimento di Medicina del Lavoro, Milano
G Ital Med Lav Ergon 29:282-4. 2007.... - Urinary polycyclic aromatic hydrocarbons and monohydroxy metabolites as biomarkers of exposure in coke oven workersF Rossella
Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8 20122 Milan, Italy
Occup Environ Med 66:509-16. 2009..To assess exposure to polycyclic aromatic hydrocarbons (PAHs) using 13 unmetabolised PAHs (U-PAHs) and 12 monohydroxy metabolites (OHPAHs) in urine, and to compare the utility of these biomarkers... - [Plastic industry and exposure to carcinogenic chemical agents: an Italian Multicentric Study in Lombardy]P E Cirla
Università degli Studi di Milano e Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena IRCCS, Dipartimento di Medicina del Lavoro, Milano
G Ital Med Lav Ergon 29:319-21. 2007.... - [Environmental and biological monitoring of exposure to PAHs in Taranto coke-oven workers and in two groups of the general population from Apulia]L Campo
Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via San Barnaba 8, 20122 Milano
G Ital Med Lav Ergon 34:655-7. 2012..3 microg/g crt) in about 90% of NC and FC. The exposure resulted lower than in the past, but this study highlights that PAHs exposure from the coke plant still poses a health risk for workers and the general population... - Immunomodulatory effects of the fungicide Mancozeb in agricultural workersEmanuela Corsini
Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
Toxicol Appl Pharmacol 208:178-85. 2005.... - [Time course of excretion of tebuconazole and its metabolites in vineyard workers]S Fustinoni
Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via S Barnaba, 8 20122 Milano, Italia
G Ital Med Lav Ergon 34:423-4. 2012..TEB-COOH has similar pattern. TEB-OH and TEB -COOH are promising candidates for biological monitoring of TEB exposure; preliminary results suggest the day after the application as the best sampling time... - Determination of monobromobimane derivatives of phenylmercapturic and benzylmercapturic acids in urine by high-performance liquid chromatography and fluorimetryM Buratti
Istituti Clinici di Perfezionamento, Laboratorio di Tossicologia Professionale, Milan, Italy
J Chromatogr B Biomed Sci Appl 751:305-13. 2001..69, P<0.01, n=17). The proposed analytical method appears to be a sensitive and specific tool for biological monitoring of low-level exposure to benzene and toluene mixtures in occupational and environmental toxicology laboratory... - Application of ultraviolet spectrophotometry to estimate occupational exposure to airborne polyaromatic compounds in asphalt paversMarina Buratti
Department of Occupational and Environmental Health, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena and University of Milan, Italy
J Occup Environ Hyg 4:412-9. 2007.... - [Occupational exposure to fungicides in floriculture in Ecuador]C Colosio
International Centre for Pesticides and Health Risk Prevention, Ospedale Universitario Luigi Sacco, Milan, Italy
G Ital Med Lav Ergon 25:107-8. 2003..Higher level ETU excretion was observed in greenhouse compared to open field workers... - Biological monitoring of exposure to polycyclic aromatic hydrocarbons by determination of unmetabolized compounds in urineLaura Campo
Department of Occupational and Environmental Health, University of Milan and Fondazione Ospedale Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8 20122 Milan, Italy
Toxicol Lett 162:132-8. 2006..05). Moreover in RP samples the urinary excretion of most analytes increased during the work shift (p<0.05). These results suggest that urinary PAHs may be useful biomarkers of occupational exposure... - Changes in serum markers indicative of health effects in vineyard workers following exposure to the fungicide mancozeb: an Italian studyClaudio Colosio
Department of Occupational and Environmental Health of the University of Milan, S Paolo Hospital Unit, Milan, Italy
Biomarkers 12:574-88. 2007..Altogether the differences between exposed and controls were not consistently correlated to any clinical impairment and suggest that the seasonal application of mancozeb does not pose a significant health risk to exposed subjects... - Assay of urinary alpha-fluoro-beta-alanine by gas chromatography-mass spectrometry for the biological monitoring of occupational exposure to 5-fluorouracil in oncology nurses and pharmacy techniciansFederico Maria Rubino
Department of Occupational Medicine, Clinica del Lavoro L Devoto, Università degli Studi di Milano at Ospedale San Paolo, Italy
Biomed Chromatogr 20:257-66. 2006..On a total number of 65 analyzed urine samples from control and exposed subjects, only three, obtained from exposed subjects, were found to be positive, with values of 20, 30 and 1150 ng/mL, respectively... - Evaluation of exposure to PAHs in asphalt workers by environmental and biological monitoringLaura Campo
Dept of Occupational and Environmental Health, University of Milan, Fondazione Ospendale Maggiore Policlinico, Mangiagalli e Regina Elena, 8 20122 Milano, Italy
Ann N Y Acad Sci 1076:405-20. 2006..The contribution of working activities to internal dose was in the same order of magnitude of the contribution of cigarette smoking... - Development of a gas chromatography/mass spectrometry method to quantify several urinary monohydroxy metabolites of polycyclic aromatic hydrocarbons in occupationally exposed subjectsLaura Campo
Department of Occupational and Environmental Health, University of Milan, Milan, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 875:531-40. 2008..4 and 69.7 microg/l, respectively), while 6-hydroxychrysene, and 3-hydroxybenzo[a]pyrene were always below the quantification limit... - Changes in DNA methylation patterns in subjects exposed to low-dose benzeneValentina Bollati
Molecular Epidemiology Laboratory, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, 20122 Milan, Italy
Cancer Res 67:876-80. 2007..20). This is the first human study to link altered DNA methylation, reproducing the aberrant epigenetic patterns found in malignant cells, to low-level carcinogen exposure... - [Identification of biomarkers of short- and medium-term exposure in urine and hair of subjects exposed to terbuthylazine]R Mercadante
Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano e Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Via S Barnaba, 8 20122 Milano, Italia
G Ital Med Lav Ergon 34:418-9. 2012..These results suggest that TBA in hair can be used as an index of cumulative exposure to TBA, while DET in the urine can be used as an index of short-term exposure in farmers... - Urinary profiles to assess polycyclic aromatic hydrocarbons exposure in coke-oven workersLaura Campo
Department of Occupational and Environmental Health, University of Milan and Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba 8, 20122 Milan, Italy
Toxicol Lett 192:72-8. 2010..Moreover, the simultaneous determination of several biomarkers permits to obtain specific excretion profiles that might help in exposure characterization and in better defining the excretion patterns... - The role of salivary cortisol measured by liquid chromatography-tandem mass spectrometry in the diagnosis of subclinical hypercortisolismS Palmieri
Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
Eur J Endocrinol 168:289-96. 2013..The aim of this study was to evaluate the diagnostic accuracy of LNSalC measured by LC-MS/MS in SH... - Determination of low level methyl tert-butyl ether, ethyl tert-butyl ether and methyl tert-amyl ether in human urine by HS-SPME gas chromatography/mass spectrometryLicia Scibetta
Department of Occupational and Environmental Medicine, University of Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8 20122 Milano, Italy
Anal Chim Acta 581:53-62. 2007.... - Quantification of 13 priority polycyclic aromatic hydrocarbons in human urine by headspace solid-phase microextraction gas chromatography-isotope dilution mass spectrometryLaura Campo
Department of Occupational and Environmental Health, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
Anal Chim Acta 631:196-205. 2009..28-2.28 x 10(1)ngL(-1) range. An application of the proposed method using 15 urine samples from subjects exposed to PAHs at different environmental levels is shown... - Development and validation of a gas chromatography/mass spectrometry method for the assessment of genomic DNA methylationFederica Rossella
Department of Occupational and Environmental Medicine, University of Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via S Barnaba, 8, 20122 Milan, Italy
Rapid Commun Mass Spectrom 23:2637-46. 2009..05%), DNA from peripheral blood leukocytes of healthy subjects (N = 6, median methylation 5.45%), DNA from bone marrow of leukemia patients (N = 5, 3.58%) and DNA from myeloma cell lines (N = 4, 2.74%)... - Reference values for ethylenethiourea in urine in Northern Italy: results of a pilot studyClaudio Colosio
International Centre for Pesticides and Health Risk Prevention of the Azienda Ospedaliera Luigi Sacco Polo Universitario, Via GB Grassi 74, 20157 Milan, Italy
Toxicol Lett 162:153-7. 2006..5-5.0 microg/g creatinine. These values can be used as reference, to compare the results of biological monitoring activities carried out on EBDCs occupationally and environmentally exposed populations... - Lack of genotoxic effect in workers exposed to very low doses of 1,3-butadienePiero Lovreglio
Department of Internal Medicine and Public Medicine, Section of Occupational Medicine, University of Bari, Piazza G. Cesare 11, 70124 Bari, Italy
Arch Toxicol 80:378-81. 2006.... - The use of S-phenylmercapturic acid as a biomarker in molecular epidemiology studies of benzenePeter B Farmer
Cancer Biomarkers and Prevention Group, Biocentre, University of Leicester, University Road, Leicester LE1 7RH, UK
Chem Biol Interact 153:97-102. 2005..55 ppm) benzene). All three biomarkers were positively correlated with smoking as measured by urinary cotinine)... - [From industrial hygiene and toxicology to environmental hygiene and toxicology: problems and prospects]P Carrer
Dipartimento di Medicina del Lavoro,
Med Lav 94:64-8. 2003..CONCLUSIONS: The challenge in this field for the coming years appears to be not the analytical but the medical and ethical implications...