Andrea Fuso

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. doi request reprint B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice
    Andrea Fuso
    Department of Surgery P Valdoni, Sapienza University of Rome, Italy
    Mol Cell Neurosci 37:731-46. 2008
  2. doi request reprint The 'golden age' of DNA methylation in neurodegenerative diseases
    Andrea Fuso
    Department of Psychology, Section of Neuroscience, Sapienza University of Rome, Rome, Italy
    Clin Chem Lab Med 51:523-34. 2013
  3. doi request reprint S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice
    Andrea Fuso
    Department of Surgery P Valdoni, Via Antonio Scarpa, 14 00161, Sapienza University of Rome, Italy
    Neurobiol Aging 33:1482.e1-16. 2012
  4. ncbi request reprint PSEN1 promoter demethylation in hyperhomocysteinemic TgCRND8 mice is the culprit, not the consequence
    Andrea Fuso
    Department of Surgery P Valdoni, Sapienza Universita di Roma, Via Antonio Scarpa, 14, 00161 Rome, Italy
    Curr Alzheimer Res 9:527-35. 2012
  5. doi request reprint One-carbon metabolism and Alzheimer's disease: is it all a methylation matter?
    Andrea Fuso
    Department of Psychology, Section of Neuroscience, Sapienza University of Rome, Rome, Italy
    Neurobiol Aging 32:1192-5. 2011
  6. doi request reprint DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models
    Andrea Fuso
    Department of Surgery P Valdoni, Sapienza University of Rome, P le Aldo Moro, 5 00185, Rome, Italy
    J Nutr Biochem 22:242-51. 2011
  7. ncbi request reprint gamma-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells
    Andrea Fuso
    Department of Surgery P Valdoni, University of Rome La Sapienza, Rome, Italy
    J Alzheimers Dis 11:275-90. 2007
  8. ncbi request reprint The effect of S-adenosylmethionine on CNS gene expression studied by cDNA microarray analysis
    Rosaria A Cavallaro
    Department of Surgery P Valdoni, Universita di Roma La Sapienza, Via A Scarpa 14, 00161 Rome, Italy
    J Alzheimers Dis 9:415-9. 2006
  9. doi request reprint One-carbon metabolism alteration affects brain proteome profile in a mouse model of Alzheimer's disease
    Marina Borro
    Department NESMOS, Azienda Ospedaliera Sant Andrea, Sapienza University of Rome, Rome, Italy
    J Alzheimers Dis 22:1257-68. 2010
  10. doi request reprint Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency
    Andrea Fuso
    Dept of Surgery P Valdoni, Sapienza Universita di Roma, Via Antonio Scarpa, 14 00161, Roma, Italy
    Neurobiol Aging 32:187-99. 2011

Collaborators

Detail Information

Publications32

  1. doi request reprint B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice
    Andrea Fuso
    Department of Surgery P Valdoni, Sapienza University of Rome, Italy
    Mol Cell Neurosci 37:731-46. 2008
    ..Collectively, these findings are consistent with the hypothesis that abnormal methylation in association with hyperhomocysteinemia may contribute to Alzheimer's disease...
  2. doi request reprint The 'golden age' of DNA methylation in neurodegenerative diseases
    Andrea Fuso
    Department of Psychology, Section of Neuroscience, Sapienza University of Rome, Rome, Italy
    Clin Chem Lab Med 51:523-34. 2013
    ..This review will present the main evidences linking several human diseases to DNA methylation, with particular focus on neurodegenerative diseases, together with a short description of the state-of-the-art of methylation assays...
  3. doi request reprint S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice
    Andrea Fuso
    Department of Surgery P Valdoni, Via Antonio Scarpa, 14 00161, Sapienza University of Rome, Italy
    Neurobiol Aging 33:1482.e1-16. 2012
    ....
  4. ncbi request reprint PSEN1 promoter demethylation in hyperhomocysteinemic TgCRND8 mice is the culprit, not the consequence
    Andrea Fuso
    Department of Surgery P Valdoni, Sapienza Universita di Roma, Via Antonio Scarpa, 14, 00161 Rome, Italy
    Curr Alzheimer Res 9:527-35. 2012
    ..We found no differences in Presenilin1 methylation despite a slight increase in gene expression; these results suggest that amyloid production is not responsible for Presenilin1 demethylation in TgCRND8 mice brain...
  5. doi request reprint One-carbon metabolism and Alzheimer's disease: is it all a methylation matter?
    Andrea Fuso
    Department of Psychology, Section of Neuroscience, Sapienza University of Rome, Rome, Italy
    Neurobiol Aging 32:1192-5. 2011
    ..In this Commentary we would like to highlight the role of 1-carbon metabolism in epigenetics and Alzheimer's disease and evidence the co-involvement of this metabolism in amyloid and tau pathways...
  6. doi request reprint DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models
    Andrea Fuso
    Department of Surgery P Valdoni, Sapienza University of Rome, P le Aldo Moro, 5 00185, Rome, Italy
    J Nutr Biochem 22:242-51. 2011
    ..We found that DNA methylases (DNMT1, 3a and 3b) and a putative demethylase (MBD2) were differently modulated, in line with the previously observed changes of PSEN1 methylation pattern in the same experimental conditions...
  7. ncbi request reprint gamma-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells
    Andrea Fuso
    Department of Surgery P Valdoni, University of Rome La Sapienza, Rome, Italy
    J Alzheimers Dis 11:275-90. 2007
    ..Moreover, we found that homocysteine alterations had an effect on neuroblastoma but not on glioblastoma cells; this suggests a possible differential role of the two cell types in Alzheimer disease...
  8. ncbi request reprint The effect of S-adenosylmethionine on CNS gene expression studied by cDNA microarray analysis
    Rosaria A Cavallaro
    Department of Surgery P Valdoni, Universita di Roma La Sapienza, Via A Scarpa 14, 00161 Rome, Italy
    J Alzheimers Dis 9:415-9. 2006
    ..In these conditions only seven genes were modulated by SAM treatment (and therefore by DNA methylation); three were up-regulated and four down-regulated, showing low levels of modulation...
  9. doi request reprint One-carbon metabolism alteration affects brain proteome profile in a mouse model of Alzheimer's disease
    Marina Borro
    Department NESMOS, Azienda Ospedaliera Sant Andrea, Sapienza University of Rome, Rome, Italy
    J Alzheimers Dis 22:1257-68. 2010
    ..These findings are consistent with increasing data about the pivotal role of mitochondrial abnormalities in AD patho-physiology. The identified proteins might represent new potential biomarkers of LOAD to be further investigated...
  10. doi request reprint Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency
    Andrea Fuso
    Dept of Surgery P Valdoni, Sapienza Universita di Roma, Via Antonio Scarpa, 14 00161, Roma, Italy
    Neurobiol Aging 32:187-99. 2011
    ..These findings pinpoint a direct relationship between B vitamin-dependent alteration of homocysteine cycle and DNA methylation and also indicate that PSEN1 promoter is regulated by methylation of specific CpG moieties...
  11. ncbi request reprint Gene silencing through methylation: an epigenetic intervention on Alzheimer disease
    Sigfrido Scarpa
    Department of Surgery P Valdoni, Universita di Roma La Sapienza, Via A Scarpa 14, 00161 Rome, Italy
    J Alzheimers Dis 9:407-14. 2006
    ..We are actually experimenting in transgenic mice the possibility to prevent or to arrest amyloid-beta accumulation, through SAM administration, and therefore its significance and the use of this drug for the treatment of the disease...
  12. doi request reprint B vitamin deficiency promotes tau phosphorylation through regulation of GSK3beta and PP2A
    Vincenzina Nicolia
    Department of Surgery P Valdoni, Sapienza University of Rome, Rome, Italy
    J Alzheimers Dis 19:895-907. 2010
    ..Therefore, one-carbon metabolism alteration seems to be a cause of deregulation of the equilibrium between GSK3beta and PP2A, leading to abnormal hyperphosphorylated tau...
  13. ncbi request reprint S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production
    Andrea Fuso
    Laboratorio di Ricerca, Dipartimento di Chirurgia P Valdoni, Universita di Roma La Sapienza, 00161 Rome, Italy
    Mol Cell Neurosci 28:195-204. 2005
    ..The use of deprived medium was intended to mimic a mild nutritional deficit involved in the onset of AD...
  14. doi request reprint S-adenosylmethionine prevents oxidative stress and modulates glutathione metabolism in TgCRND8 mice fed a B-vitamin deficient diet
    Rosaria A Cavallaro
    Department of Surgery Pietro Valdoni, Sapienza University of Rome, Rome, Italy
    J Alzheimers Dis 20:997-1002. 2010
    ..These results underline the importance of S-adenosylmethionine as neuroprotective compound, acting both on methylation and oxidation metabolism...
  15. doi request reprint Nicotine inhibits apoptosis and stimulates proliferation in aortic smooth muscle cells through a functional nicotinic acetylcholine receptor
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, La Sapienza University of Rome, Rome, Italy
    J Surg Res 150:227-35. 2008
    ..We also showed that nicotine signaling occurs as a result of activation of the classical nicotine receptor pathways...
  16. pmc Early demethylation of non-CpG, CpC-rich, elements in the myogenin 5'-flanking region: a priming effect on the spreading of active demethylation
    Andrea Fuso
    Department of Surgery P Valdoni, Sapienza University of Rome, Italy
    Cell Cycle 9:3965-76. 2010
    ..The short CpC-rich elements are new structural features of the methylation machinery, whose functions may include priming the complete demethylation of a transcriptionally crucial DNA region...
  17. doi request reprint Neonatal exposure to low dose corticosterone persistently modulates hippocampal mineralocorticoid receptor expression and improves locomotor/exploratory behaviour in a mouse model of Rett syndrome
    Bianca De Filippis
    Sect Behavioural Neuroscience, Dept Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Neuropharmacology 68:174-83. 2013
    ..This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'...
  18. doi request reprint Distribution of GFRA1-expressing spermatogonia in adult mouse testis
    Margherita Grasso
    Fondazione Pasteur Cenci Bolognetti, Section of Histology and Medical Embryology, Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, La Sapienza University of Rome, Via Antonio Scarpa 14, 00161 Rome, Italy
    Reproduction 143:325-32. 2012
    ..Our data indicate that GDNF, besides its crucial role in the self-renewal of stem cells also functions in the differentiation of chained undifferentiated spermatogonia...
  19. ncbi request reprint S-adenosylmethionine inhibits ubiquitin-proteasome system in vitro and on rat vascular smooth muscle cells
    Fabrizio D'Anselmi
    Department of Surgery P Valdoni, University of Rome La Sapienza, Italy
    Protein Pept Lett 15:58-62. 2008
    ..We found that S-adenosylmethionine inhibited UPS activity...
  20. doi request reprint Subcellular TSC22D4 localization in cerebellum granule neurons of the mouse depends on development and differentiation
    Sonia Canterini
    Department of Psychology, Section of Neuroscience, Istituto Pasteur Fondazione Cenci Bolognetti and D Bovet Research Center, Sapienza University of Rome, Rome, Italy
    Cerebellum 11:28-40. 2012
    ..In vitro TSC22D4 silencing with siRNAs blocked CGN differentiation and inhibited neurite elongation in N1E-115 neuroblastoma cells, pinpointing the relevance of this protein to CGN differentiation...
  21. ncbi request reprint Evaluation of chemical and diastereoisomeric stability of S-adenosylmethionine in aqueous solution by capillary electrophoresis
    Claudia Desiderio
    Istituto di Metodologie Chimiche, Consiglio Nazionale delle Ricerche, CNR, Area della Ricerca Roma 1, Via Salaria Km 29, 300, 00016 Monterotondo Stazione, Rome, Italy
    J Pharm Biomed Anal 38:449-56. 2005
    ..After 7 and 14 days only the 52% and 32% of the initial drug concentration were available and the active S,S-S-adenosylmethionine form was the most affected...
  22. doi request reprint Nicotine restores Wt-like levels of reelin and GAD67 gene expression in brain of heterozygous reeler mice
    Emilia Romano
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Neurotox Res 24:205-15. 2013
    ..These findings are interpreted within the hypothesis of pre-existing vulnerability (based on haploinsufficiency of reelin) to brain and behavioral disorders and regulative effects associated with nicotine exposure. ..
  23. pmc Alzheimer's disease promotion by obesity: induced mechanisms-molecular links and perspectives
    Rita Businaro
    Medico Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy
    Curr Gerontol Geriatr Res 2012:986823. 2012
    ..The involved molecular mechanisms will be briefly discussed, and advisable guide lines for the prevention of AD through lifestyle modifications will be proposed...
  24. doi request reprint Stress-induced cytokines and neuronal dysfunction in Alzheimer's disease
    Serafino Ricci
    Department of Anatomy Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, Rome, Italy
    J Alzheimers Dis 28:11-24. 2012
    ..Lifestyle and environmental factors related to metabolic and inflammatory alterations observed in stressed subjects and thought to favor AD development and progression, as well as the possible ways of prevention, are discussed...
  25. ncbi request reprint Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?
    Sigfrido Scarpa
    Dipartimento di Chirurgia P Valdoni, Universita di Roma La Sapienza, Rome, Italy
    FEBS Lett 541:145-8. 2003
    ..Here we report that SAM administration, in human neuroblastoma SK-N-SH cell cultures, downregulates PS1 gene expression and Ab production...
  26. ncbi request reprint Nicotine exposure during adolescence: cognitive performance and brain gene expression in adult heterozygous reeler mice
    Emilia Romano
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Psychopharmacology (Berl) 231:1775-87. 2014
    ....
  27. ncbi request reprint A reassessment of semiquantitative analytical procedures for DNA methylation: comparison of bisulfite- and HpaII polymerase-chain-reaction-based methods
    Andrea Fuso
    Department of Surgery P Valdoni, University of Rome La Sapienza, Italy
    Anal Biochem 350:24-31. 2006
    ....
  28. doi request reprint Cholinergic hypofunction in MeCP2-308 mice: beneficial neurobehavioural effects of neonatal choline supplementation
    Laura Ricceri
    Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    Behav Brain Res 221:623-9. 2011
    ..As a whole, postnatal choline supplementation attenuates some of the behavioural and neurobiological abnormalities of the Mecp2-308 phenotype...
  29. doi request reprint Urokinase expression in course of benign and malignant mammary lesions: comparison between nodular and healthy tissues
    Francesca Ceccarelli
    UOC Medicina Territoriale Chirurgica e Prevenzione Oncologica, Department of Surgery P Valdoni, Sapienza University of Rome, C so Vittorio Emanuele II, 244, 00186 Rome, Italy
    J Cancer Res Clin Oncol 136:157-63. 2010
    ..uPA overexpression in cancer tissues was correlated with a more aggressive phenotype and it is considered a strong and independent unfavorable prognostic factor in breast cancer...
  30. ncbi request reprint High density lipoproteins downregulate basic fibroblast growth factor production and release in minimally oxidated-LDL treated smooth muscle cells
    Alessandra Cucina
    Department of Surgery Pietro Valdoni, University of Rome La Sapienza, Via A Scarpa, 14, 00161 Rome, Italy
    Atherosclerosis 189:303-9. 2006
    ..0) produced the inhibition of MM-LDL effects. Our data suggest that the protective role of HDL could also be exerted through the inhibition of the pro-atherosclerotic effects of MM-LDL on SMCs...
  31. doi request reprint Identification of spermatogonial stem cell subsets by morphological analysis and prospective isolation
    Laura Grisanti
    Fondazione Pasteur Cenci Bolognetti, Department of Histology and Medical Embryology, and La Sapienza University of Rome, Rome, Italy
    Stem Cells 27:3043-52. 2009
    ..Our data support the hypothesis of the existence of SSC subsets and reveal a previously unrecognized heterogeneity in the expression profile of As spermatogonia in vivo...
  32. ncbi request reprint Sertoli cells initiate testicular innate immune responses through TLR activation
    Anna Riccioli
    Department of Histology and Medical Embryology, Istituto Pasteur Fondazione Cenci Bolognetti, University of Rome La Sapienza, Rome, Italy
    J Immunol 177:7122-30. 2006
    ..Collectively, this study demonstrates the novel ability of Sertoli cells to potentially respond to a wide variety of bacteria through TLR stimulation...