Affiliation: University of Rome La Sapienza
Fucile S, Lax P, Eusebi F. Nicotine modulates the spontaneous synaptic activity in cultured embryonic rat spinal cord interneurons. J Neurosci Res. 2002;67:329-36 pubmed
..Our results provide the first evidence of modulation of both excitatory and inhibitory neurotransmitter release in embryonic spinal cord interneurons by non-alpha7-containing nicotinic receptors. ..
Plutino S, Sciaccaluga M, Fucile S. Extracellular mild acidosis decreases the Ca2+ permeability of the human NMDA receptors. Cell Calcium. 2019;80:63-70 pubmed publisher
..Furthermore, this study provides the proof of concept that it is possible to reduce Ca2+ overload in neurons modulating the NMDAR Ca2+ permeability. ..
Fucile S, Renzi M, Lax P, Eusebi F. Fractional Ca(2+) current through human neuronal alpha7 nicotinic acetylcholine receptors. Cell Calcium. 2003;34:205-9 pubmed
..In our knowledge, the findings here reported indicate the human alpha7 receptors are the most Ca(2+) conductive homomeric ligand-gated receptor-channels expressed in a heterologous cell system. ..
Fucile S, Miledi R, Eusebi F. Effects of cyclothiazide on GluR1/AMPA receptors. Proc Natl Acad Sci U S A. 2006;103:2943-7 pubmed
..We also present a kinetic model that predicts well all of the experimental findings of CTZ action. Finally, we suggest a protocol for standard cell treatment with CTZ to attain maximal efficacy of CTZ on GluR1 receptors. ..
Fucile S, Renzi M, Lauro C, Limatola C, Ciotti T, Eusebi F. Nicotinic cholinergic stimulation promotes survival and reduces motility of cultured rat cerebellar granule cells. Neuroscience. 2004;127:53-61 pubmed
Fucile S, Sucapane A, Eusebi F. Ca2+ permeability of nicotinic acetylcholine receptors from rat dorsal root ganglion neurones. J Physiol. 2005;565:219-28 pubmed
..Finally, we report that Ca2+ influx through nAChRs in adult DRG neurones negatively modulated the TRPV1-mediated responses, representing a possible mechanism underlying the analgesic properties of nicotinic agonists on sensory neurones. ..
Sciaccaluga M, Moriconi C, Martinello K, Catalano M, Bermudez I, Stitzel J, et al
. Crucial role of nicotinic Î±5 subunit variants for Ca2+ fluxes in ventral midbrain neurons. FASEB J. 2015;29:3389-98 pubmed publisher