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Genomes and Genes | Simonetta FrisoSummaryAffiliation: University of Verona Country: Italy Publications
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Publications
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate statusSimonetta Friso
Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 99:5606-11. 2002..03) that is known to be solely represented in those individuals. These results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status...- Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer riskSimonetta Friso
Corresponding Author Simonetta Friso, Department of Medicine, University of Verona School of Medicine, Policlinico G B Rossi, P le L A Scuro, 10, 37134 Verona, Italy
Cancer Epidemiol Biomarkers Prev 22:348-55. 2013..Whether methylation measured in peripheral blood mononuclear cells (PBMCs) DNA is a clinically reliable biomarker for early detection or cancer risk assessment is to be established... 
Promoter methylation in coagulation F7 gene influences plasma FVII concentrations and relates to coronary artery diseaseSimonetta Friso
Department of Medicine, University of Verona School of Medicine, Verona, Italy
J Med Genet 49:192-9. 2012..Transcriptional regulation of F7 by epigenetic features is, however, still unknown as is the inter-relationship of genetic and epigenetic modifications at the promoter site...
The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lymphocytesSimonetta Friso
Department of Clinical and Experimental Medicine, University of Verona, Policlinico Giambattista Rossi, Piazza Ludovico Antonio Scuro, 10, 37134 Verona, Italy
Cancer Epidemiol Biomarkers Prev 14:938-43. 2005..Further mechanistic studies are warranted to investigate how single polymorphisms as well as MTHFR combined genotypes exert their effect on cancer susceptibility...- Gene-nutrient interactions in one-carbon metabolismSimonetta Friso
Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Policlinico Giambattista Rossi, P le L A Scuro, 10, 37134 Verona, Italy
Curr Drug Metab 6:37-46. 2005.... - Oestrogen replacement therapy reduces total plasma homocysteine and enhances genomic DNA methylation in postmenopausal womenSimonetta Friso
Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Policlinico G B Rossi, P le L A Scuro 10, 37134 Verona, Italy
Br J Nutr 97:617-21. 2007.... - Low plasma vitamin B-6 concentrations and modulation of coronary artery disease riskSimonetta Friso
Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
Am J Clin Nutr 79:992-8. 2004..Both low PLP and elevated inflammatory markers, such as high-sensitivity CRP (hs-CRP) and fibrinogen, are related to higher risk of coronary artery disease (CAD)... - Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertensionSimonetta Friso
Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
Atherosclerosis 199:323-7. 2008..Little is known, however, of human HSD11B2 epigenetic control and its relationship with the onset of hypertension... - The potential cocarcinogenic effect of vitamin B12 deficiencySimonetta Friso
Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
Clin Chem Lab Med 43:1158-63. 2005.... - Vitamin b6 and cardiovascular diseaseSimonetta Friso
Tufts University, Medford Somerville, MA, USA
Subcell Biochem 56:265-90. 2012.... - The -1131 T>C and S19W APOA5 gene polymorphisms are associated with high levels of triglycerides and apolipoprotein C-III, but not with coronary artery disease: an angiographic studyNicola Martinelli
University of Verona, Department of Clinical and Experimental Medicine, Italy
Atherosclerosis 191:409-17. 2007..Different genotypes, i.e., APOA5 and APOC3 variants, may lead to similar biochemical phenotypes, namely hypertriglyceridemia, but to contrasting clinical phenotypes such as the presence of angiographically proven CAD... - Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosisNicola Martinelli
Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
PLoS ONE 3:e1523. 2008..The aim of this study was to evaluate the combined effect of ten common prothrombotic polymorphisms as a determinant of MI... - ALOX5AP gene variants and risk of coronary artery disease: an angiography-based studyDomenico Girelli
Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
Eur J Hum Genet 15:959-66. 2007..Our angiography-based study suggests a possible modest role of ALOX5AP in the development of the atheroma rather than in its late thrombotic complications such as MI... - Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colonMary K Keyes
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02478, USA
J Nutr 137:1713-7. 2007..041), but not in the folate-deplete group. In conclusion, aging decreases genomic DNA methylation and increases promoter methylation and expression of p16 in mouse colons. This effect is dependent on the level of dietary folate... - Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colonJulia Sauer
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
Br J Nutr 104:24-30. 2010.... - Apolipoprotein C-III, metabolic syndrome, and risk of coronary artery diseaseOliviero Olivieri
Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
J Lipid Res 44:2374-81. 2003..6% vs. 34.8%, P < 0.05). In conclusion, apoC-III-rich lipoprotein metabolism and the APOC3 polymorphism have relevant impacts on the CAD risk of MS patents... - Additive effect of LRP8/APOER2 R952Q variant to APOE epsilon2/epsilon3/epsilon4 genotype in modulating apolipoprotein E concentration and the risk of myocardial infarction: a case-control studyNicola Martinelli
Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
BMC Med Genet 10:41. 2009.... - Hyperhomocysteinemia and mortality after coronary artery bypass graftingDomenico Girelli
Department of Clinical and Experimental Medicine, University of Verona, Italy
PLoS ONE 1:e83. 2006..No previous study specifically has addressed the relationship between HHcy and mortality after coronary artery bypass grafting (CABG) surgery. The aim of this study is to evaluate the prognostic impact of HHcy after CABG surgery... - The interaction between MTHFR 677 C-->T genotype and folate status is a determinant of coronary atherosclerosis riskDomenico Girelli
Department of Clinical and Experimental Medicine, Institute of Biology and Genetics, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
J Nutr 133:1281-5. 2003..8, 95% CI, 1.03-3.15). A gene-nutrient interaction that defines a higher risk for CAD is determined by folate levels below specific thresholds, which differ depending on the MTHFR 677 C-->T genotype... - Apolipoprotein C-III, n-3 polyunsaturated fatty acids, and "insulin-resistant" T-455C APOC3 gene polymorphism in heart disease patients: example of gene-diet interactionOliviero Olivieri
Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
Clin Chem 51:360-7. 2005..The T-455C polymorphism in the insulin-responsive element of the APOC3 gene influences TG and apo C-III concentrations. Long-chain n-3 polyunsaturated fatty acids (PUFAs) contained in fish have well-known apo C-III-lowering properties... - Influence of polymorphisms in the factor VII gene promoter on activated factor VII levels and on the risk of myocardial infarction in advanced coronary atherosclerosisClaudia Bozzini
Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
Thromb Haemost 92:541-9. 2004..This study highlights a "within-gene" interaction, and the need to explore polymorphisms in candidate gene(s) in detail... - Prevalence of body iron excess in the metabolic syndromeClaudia Bozzini
Department of Clinical and Experimental Medicine, University of Verona, Policlinico G.B. Rossi, 37134 Verona, Italy
Diabetes Care 28:2061-3. 2005 - Folic acid effects on s-adenosylmethionine, s-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemiaFrancesca Pizzolo
Department of Medicine, University of Verona School of Medicine, Verona, Italy
J Am Coll Nutr 30:11-8. 2011..The purpose of this study was to investigate the effects of FA supplementation on AdoMet, AdoHcy, and genomic DNA methylation in hyperhomocysteinemic subjects without end-stage renal disease... - Urinary cortisol to cortisone metabolites ratio in prednisone-treated and spontaneously hypertensive patientsOliviero Olivieri
Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Italy
J Hypertens 26:486-93. 2008.... - FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery diseaseNicola Martinelli
Department of Clinical and Experimental Medicine and the Section of Biology and Genetics, University of Verona, Verona, Italy
Am J Clin Nutr 88:941-9. 2008..Single-nucleotide polymorphisms (SNPs) in FADS1 and FADS2 have been associated with different concentrations of AA and LA, and those associations have possible functional consequences for desaturase activity... - Novel serum paraoxonase activity assays are associated with coronary artery diseaseNicola Martinelli
Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
Clin Chem Lab Med 47:432-40. 2009..The aim of this study was to evaluate for the first time TBBLase and DEPCyMCase activity in patients with coronary artery disease (CAD)... - Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery diseaseNicola Martinelli
Department of Medicine, University of Verona, Policlinico G B Rossi, Italy
Exp Diabetes Res 2012:231502. 2012..45 with 95% CI 0.47-4.46). Our results suggest that low PON1 concentrations are typical in MS and may modulate the MS-related risk of CAD... - Folate supplementation increases genomic DNA methylation in the liver of elder ratsSANG WOON CHOI
US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Br J Nutr 93:31-5. 2005..48, P=0.004). In the liver of this animal model, dietary folate over a wide range of intakes modulates genomic DNA methylation... - Vitamin B6: a challenging link between nutrition and inflammation in CVDValentina Lotto
Department of Medicine, University of Verona School of Medicine, Policlinico GB Rossi, Verona, Italy
Br J Nutr 106:183-95. 2011..A mild vitamin B6 deficiency characterises, in most cases, a subclinical at-risk condition in inflammatory-linked diseases which should be addressed by an appropriate individually tailored nutritional preventive or therapeutic strategy... - Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specificSANG WOON CHOI
Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Nutr 133:1206-12. 2003..However, folate supplementation is as effective at sustaining adequate colonic folate status in elder rats as it is in the young... - Gene-nutrient interactions and DNA methylationSimonetta Friso
Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
J Nutr 132:2382S-2387S. 2002.... - Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring Study CohortGiuseppina T Russo
Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
J Nutr 133:3416-21. 2003..001). Our results suggest that age and sex modify the contribution of the MTHFR C677T mutation to fasting tHcy concentrations... - Vitamins b6 and cancerSANG WOON CHOI
Tufts University, Medford Somerville, MA, USA
Subcell Biochem 56:247-64. 2012..This chapter addressed currently available information regarding the relationship between vitamin B6 and cancer... - Interactions between folate and aging for carcinogenesisSANG WOON CHOI
Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
Clin Chem Lab Med 43:1151-7. 2005..These studies have further indicated that modest folate supplementation may reverse or partially ameliorate those adverse effects induced by folate depletion and aging... - Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epitheliumSANG WOON CHOI
Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston MA 02111, USA
J Nutr 134:750-5. 2004..05). This vitamin B-12-deficient diet, which was of insufficient severity to cause anemia or illness, created aberrations in both base substitution and methylation of colonic DNA, which might increase susceptibility to carcinogenesis... - S-adenosyl-L-methionine increases skeletal muscle mitochondrial DNA density and whole body insulin sensitivity in OLETF ratsCheng Ji Jin
Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
J Nutr 137:339-44. 2007..752, P<0.001). In conclusion, SAM treatment increased mtDNA density in the skeletal muscle, improved whole body insulin sensitivity, and prevented body weight gain in OLETF rats... - A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometrySimonetta Friso
Vitamin Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research on Aging at Tufts University, Boston, Massachusetts 02111, USA
Anal Chem 74:4526-31. 2002..9 (within-day) and 1.7 (day-to-day). This LC/MS method for quantitative determination of genomic DNA methylation status is rapid, sensitive, selective, and precise... - Tacrolimus ointment in nickel sulphate-induced steroid-resistant allergic contact dermatitisMaria L Pacor
Dipartimento di Medicina Clinica e Sperimentale, , Italy
Allergy Asthma Proc 27:527-31. 2006..No patients withdrew because of burning/itching. In our study, tacrolimus ointment 0.1% appeared to be both effective and safe in the treatment of nickel sulfate-induced steroid-resistant ACD...