Affiliation: University of Verona
- Friso S, Udali S, De Santis D, CHOI S. One-carbon metabolism and epigenetics. Mol Aspects Med. 2017;54:28-36 pubmed publisher..The present review will focus on the link between one-carbon nutrients and epigenetic phenomena based on the current knowledge from findings in cell culture, animal models and human studies. ..
- Friso S, Pizzolo F, CHOI S, Guarini P, Castagna A, Ravagnani V, et al. Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension. Atherosclerosis. 2008;199:323-7 pubmed publisher..Essential hypertensives with elevated urinary THFs/THE ratio also showed higher HSD11B2 promoter methylation. These results show a clear link between the epigenetic regulation through repression of HSD11B2 in PBMC DNA and hypertension. ..
- Friso S, Lotto V, CHOI S, Girelli D, Pinotti M, Guarini P, et al. Promoter methylation in coagulation F7 gene influences plasma FVII concentrations and relates to coronary artery disease. J Med Genet. 2012;49:192-9 pubmed publisher..011). Epigenetic regulation through methylation of F7 promoter is associated with CAD by affecting plasma FVIIa concentrations in A1A1 genotypes. ..
- Friso S, Udali S, Guarini P, Pellegrini C, Pattini P, Moruzzi S, et al. Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk. Cancer Epidemiol Biomarkers Prev. 2013;22:348-55 pubmed publisher..This study identifies a threshold for PBMCs-DNA methylation to detect cancer-affected from cancer-free subjects and an at-risk condition for cancer based on genomic DNA methylation and MTHFR677C>T-folate status. ..