Simonetta Friso

Summary

Affiliation: University of Verona
Country: Italy

Publications

  1. pmc A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 99:5606-11. 2002
  2. pmc Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk
    Simonetta Friso
    Corresponding Author Simonetta Friso, Department of Medicine, University of Verona School of Medicine, Policlinico G B Rossi, P le L A Scuro, 10, 37134 Verona, Italy
    Cancer Epidemiol Biomarkers Prev 22:348-55. 2013
  3. doi request reprint Promoter methylation in coagulation F7 gene influences plasma FVII concentrations and relates to coronary artery disease
    Simonetta Friso
    Department of Medicine, University of Verona School of Medicine, Verona, Italy
    J Med Genet 49:192-9. 2012
  4. ncbi request reprint The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lymphocytes
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico Giambattista Rossi, Piazza Ludovico Antonio Scuro, 10, 37134 Verona, Italy
    Cancer Epidemiol Biomarkers Prev 14:938-43. 2005
  5. ncbi request reprint Gene-nutrient interactions in one-carbon metabolism
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Policlinico Giambattista Rossi, P le L A Scuro, 10, 37134 Verona, Italy
    Curr Drug Metab 6:37-46. 2005
  6. ncbi request reprint Oestrogen replacement therapy reduces total plasma homocysteine and enhances genomic DNA methylation in postmenopausal women
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Policlinico G B Rossi, P le L A Scuro 10, 37134 Verona, Italy
    Br J Nutr 97:617-21. 2007
  7. ncbi request reprint Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
    Am J Clin Nutr 79:992-8. 2004
  8. doi request reprint Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
    Atherosclerosis 199:323-7. 2008
  9. ncbi request reprint The potential cocarcinogenic effect of vitamin B12 deficiency
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
    Clin Chem Lab Med 43:1158-63. 2005
  10. doi request reprint Vitamin b6 and cardiovascular disease
    Simonetta Friso
    Tufts University, Medford Somerville, MA, USA
    Subcell Biochem 56:265-90. 2012

Collaborators

Detail Information

Publications41

  1. pmc A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 99:5606-11. 2002
    ..03) that is known to be solely represented in those individuals. These results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status...
  2. pmc Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk
    Simonetta Friso
    Corresponding Author Simonetta Friso, Department of Medicine, University of Verona School of Medicine, Policlinico G B Rossi, P le L A Scuro, 10, 37134 Verona, Italy
    Cancer Epidemiol Biomarkers Prev 22:348-55. 2013
    ..Whether methylation measured in peripheral blood mononuclear cells (PBMCs) DNA is a clinically reliable biomarker for early detection or cancer risk assessment is to be established...
  3. doi request reprint Promoter methylation in coagulation F7 gene influences plasma FVII concentrations and relates to coronary artery disease
    Simonetta Friso
    Department of Medicine, University of Verona School of Medicine, Verona, Italy
    J Med Genet 49:192-9. 2012
    ..Transcriptional regulation of F7 by epigenetic features is, however, still unknown as is the inter-relationship of genetic and epigenetic modifications at the promoter site...
  4. ncbi request reprint The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lymphocytes
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico Giambattista Rossi, Piazza Ludovico Antonio Scuro, 10, 37134 Verona, Italy
    Cancer Epidemiol Biomarkers Prev 14:938-43. 2005
    ..Further mechanistic studies are warranted to investigate how single polymorphisms as well as MTHFR combined genotypes exert their effect on cancer susceptibility...
  5. ncbi request reprint Gene-nutrient interactions in one-carbon metabolism
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Policlinico Giambattista Rossi, P le L A Scuro, 10, 37134 Verona, Italy
    Curr Drug Metab 6:37-46. 2005
    ....
  6. ncbi request reprint Oestrogen replacement therapy reduces total plasma homocysteine and enhances genomic DNA methylation in postmenopausal women
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Policlinico G B Rossi, P le L A Scuro 10, 37134 Verona, Italy
    Br J Nutr 97:617-21. 2007
    ....
  7. ncbi request reprint Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
    Am J Clin Nutr 79:992-8. 2004
    ..Both low PLP and elevated inflammatory markers, such as high-sensitivity CRP (hs-CRP) and fibrinogen, are related to higher risk of coronary artery disease (CAD)...
  8. doi request reprint Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
    Atherosclerosis 199:323-7. 2008
    ..Little is known, however, of human HSD11B2 epigenetic control and its relationship with the onset of hypertension...
  9. ncbi request reprint The potential cocarcinogenic effect of vitamin B12 deficiency
    Simonetta Friso
    Department of Clinical and Experimental Medicine, University of Verona School of Medicine, Verona, Italy
    Clin Chem Lab Med 43:1158-63. 2005
    ....
  10. doi request reprint Vitamin b6 and cardiovascular disease
    Simonetta Friso
    Tufts University, Medford Somerville, MA, USA
    Subcell Biochem 56:265-90. 2012
    ....
  11. ncbi request reprint The -1131 T>C and S19W APOA5 gene polymorphisms are associated with high levels of triglycerides and apolipoprotein C-III, but not with coronary artery disease: an angiographic study
    Nicola Martinelli
    University of Verona, Department of Clinical and Experimental Medicine, Italy
    Atherosclerosis 191:409-17. 2007
    ..Different genotypes, i.e., APOA5 and APOC3 variants, may lead to similar biochemical phenotypes, namely hypertriglyceridemia, but to contrasting clinical phenotypes such as the presence of angiographically proven CAD...
  12. pmc Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    PLoS ONE 3:e1523. 2008
    ..The aim of this study was to evaluate the combined effect of ten common prothrombotic polymorphisms as a determinant of MI...
  13. ncbi request reprint ALOX5AP gene variants and risk of coronary artery disease: an angiography-based study
    Domenico Girelli
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Eur J Hum Genet 15:959-66. 2007
    ..Our angiography-based study suggests a possible modest role of ALOX5AP in the development of the atheroma rather than in its late thrombotic complications such as MI...
  14. pmc Ageing, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon
    Julia Sauer
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA
    Br J Nutr 104:24-30. 2010
    ....
  15. ncbi request reprint Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon
    Mary K Keyes
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02478, USA
    J Nutr 137:1713-7. 2007
    ..041), but not in the folate-deplete group. In conclusion, aging decreases genomic DNA methylation and increases promoter methylation and expression of p16 in mouse colons. This effect is dependent on the level of dietary folate...
  16. ncbi request reprint Apolipoprotein C-III, metabolic syndrome, and risk of coronary artery disease
    Oliviero Olivieri
    Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    J Lipid Res 44:2374-81. 2003
    ..6% vs. 34.8%, P < 0.05). In conclusion, apoC-III-rich lipoprotein metabolism and the APOC3 polymorphism have relevant impacts on the CAD risk of MS patents...
  17. pmc Additive effect of LRP8/APOER2 R952Q variant to APOE epsilon2/epsilon3/epsilon4 genotype in modulating apolipoprotein E concentration and the risk of myocardial infarction: a case-control study
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    BMC Med Genet 10:41. 2009
    ....
  18. ncbi request reprint The interaction between MTHFR 677 C-->T genotype and folate status is a determinant of coronary atherosclerosis risk
    Domenico Girelli
    Department of Clinical and Experimental Medicine, Institute of Biology and Genetics, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    J Nutr 133:1281-5. 2003
    ..8, 95% CI, 1.03-3.15). A gene-nutrient interaction that defines a higher risk for CAD is determined by folate levels below specific thresholds, which differ depending on the MTHFR 677 C-->T genotype...
  19. pmc Hyperhomocysteinemia and mortality after coronary artery bypass grafting
    Domenico Girelli
    Department of Clinical and Experimental Medicine, University of Verona, Italy
    PLoS ONE 1:e83. 2006
    ..No previous study specifically has addressed the relationship between HHcy and mortality after coronary artery bypass grafting (CABG) surgery. The aim of this study is to evaluate the prognostic impact of HHcy after CABG surgery...
  20. ncbi request reprint Apolipoprotein C-III, n-3 polyunsaturated fatty acids, and "insulin-resistant" T-455C APOC3 gene polymorphism in heart disease patients: example of gene-diet interaction
    Oliviero Olivieri
    Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Clin Chem 51:360-7. 2005
    ..The T-455C polymorphism in the insulin-responsive element of the APOC3 gene influences TG and apo C-III concentrations. Long-chain n-3 polyunsaturated fatty acids (PUFAs) contained in fish have well-known apo C-III-lowering properties...
  21. ncbi request reprint Influence of polymorphisms in the factor VII gene promoter on activated factor VII levels and on the risk of myocardial infarction in advanced coronary atherosclerosis
    Claudia Bozzini
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    Thromb Haemost 92:541-9. 2004
    ..This study highlights a "within-gene" interaction, and the need to explore polymorphisms in candidate gene(s) in detail...
  22. ncbi request reprint Folic acid effects on s-adenosylmethionine, s-adenosylhomocysteine, and DNA methylation in patients with intermediate hyperhomocysteinemia
    Francesca Pizzolo
    Department of Medicine, University of Verona School of Medicine, Verona, Italy
    J Am Coll Nutr 30:11-8. 2011
    ..The purpose of this study was to investigate the effects of FA supplementation on AdoMet, AdoHcy, and genomic DNA methylation in hyperhomocysteinemic subjects without end-stage renal disease...
  23. doi request reprint Urinary cortisol to cortisone metabolites ratio in prednisone-treated and spontaneously hypertensive patients
    Oliviero Olivieri
    Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of Verona, Italy
    J Hypertens 26:486-93. 2008
    ....
  24. ncbi request reprint Prevalence of body iron excess in the metabolic syndrome
    Claudia Bozzini
    Department of Clinical and Experimental Medicine, University of Verona, Policlinico G B Rossi, 37134 Verona, Italy
    Diabetes Care 28:2061-3. 2005
  25. doi request reprint Novel serum paraoxonase activity assays are associated with coronary artery disease
    Nicola Martinelli
    Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Clin Chem Lab Med 47:432-40. 2009
    ..The aim of this study was to evaluate for the first time TBBLase and DEPCyMCase activity in patients with coronary artery disease (CAD)...
  26. ncbi request reprint FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease
    Nicola Martinelli
    Department of Clinical and Experimental Medicine and the Section of Biology and Genetics, University of Verona, Verona, Italy
    Am J Clin Nutr 88:941-9. 2008
    ..Single-nucleotide polymorphisms (SNPs) in FADS1 and FADS2 have been associated with different concentrations of AA and LA, and those associations have possible functional consequences for desaturase activity...
  27. pmc Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery disease
    Nicola Martinelli
    Department of Medicine, University of Verona, Policlinico G B Rossi, Italy
    Exp Diabetes Res 2012:231502. 2012
    ..45 with 95% CI 0.47-4.46). Our results suggest that low PON1 concentrations are typical in MS and may modulate the MS-related risk of CAD...
  28. doi request reprint Cardiovascular epigenetics: from DNA methylation to microRNAs
    Silvia Udali
    Department of Medicine, University of Verona School of Medicine, Verona, Italy
    Mol Aspects Med 34:883-901. 2013
    ..This review focuses on up-to-date knowledge pertaining to the role of epigenetics, from DNA methylation to miRNAs, in major cardiovascular diseases such as ischemic heart disease, hypertension, heart failure and stroke...
  29. ncbi request reprint Folate supplementation increases genomic DNA methylation in the liver of elder rats
    SANG WOON CHOI
    US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Br J Nutr 93:31-5. 2005
    ..48, P=0.004). In the liver of this animal model, dietary folate over a wide range of intakes modulates genomic DNA methylation...
  30. pmc Factor II activity is similarly increased in patients with elevated apolipoprotein CIII and in carriers of the factor II 20210A allele
    Oliviero Olivieri
    Department of Medicine, Unit of Internal Medicine, University of Verona, Verona, Italy
    J Am Heart Assoc 2:e000440. 2013
    ..Few studies have so far investigated the relationship between apolipoprotein CIII (Apo CIII) and coagulation pathway in subjects with or without coronary artery disease (CAD)...
  31. doi request reprint Vitamin B6: a challenging link between nutrition and inflammation in CVD
    Valentina Lotto
    Department of Medicine, University of Verona School of Medicine, Policlinico GB Rossi, Verona, Italy
    Br J Nutr 106:183-95. 2011
    ..A mild vitamin B6 deficiency characterises, in most cases, a subclinical at-risk condition in inflammatory-linked diseases which should be addressed by an appropriate individually tailored nutritional preventive or therapeutic strategy...
  32. ncbi request reprint Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:1206-12. 2003
    ..However, folate supplementation is as effective at sustaining adequate colonic folate status in elder rats as it is in the young...
  33. ncbi request reprint Gene-nutrient interactions and DNA methylation
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Nutr 132:2382S-2387S. 2002
    ....
  34. ncbi request reprint Age and gender affect the relation between methylenetetrahydrofolate reductase C677T genotype and fasting plasma homocysteine concentrations in the Framingham Offspring Study Cohort
    Giuseppina T Russo
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    J Nutr 133:3416-21. 2003
    ..001). Our results suggest that age and sex modify the contribution of the MTHFR C677T mutation to fasting tHcy concentrations...
  35. pmc Epigenetics: the link between nature and nurture
    Stephanie A Tammen
    Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University, Boston, MA 02111, USA
    Mol Aspects Med 34:753-64. 2013
    ..The interaction between types of epigenetic modifications in response to environmental factors and how environmental cues affect epigenetic patterns will further elucidate how gene transcription can be affectively altered...
  36. doi request reprint Vitamins b6 and cancer
    SANG WOON CHOI
    Tufts University, Medford Somerville, MA, USA
    Subcell Biochem 56:247-64. 2012
    ..This chapter addressed currently available information regarding the relationship between vitamin B6 and cancer...
  37. ncbi request reprint Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston MA 02111, USA
    J Nutr 134:750-5. 2004
    ..05). This vitamin B-12-deficient diet, which was of insufficient severity to cause anemia or illness, created aberrations in both base substitution and methylation of colonic DNA, which might increase susceptibility to carcinogenesis...
  38. ncbi request reprint Interactions between folate and aging for carcinogenesis
    SANG WOON CHOI
    Vitamins and Carcinogenesis Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Chem Lab Med 43:1151-7. 2005
    ..These studies have further indicated that modest folate supplementation may reverse or partially ameliorate those adverse effects induced by folate depletion and aging...
  39. ncbi request reprint A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry
    Simonetta Friso
    Vitamin Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Anal Chem 74:4526-31. 2002
    ..9 (within-day) and 1.7 (day-to-day). This LC/MS method for quantitative determination of genomic DNA methylation status is rapid, sensitive, selective, and precise...
  40. ncbi request reprint S-adenosyl-L-methionine increases skeletal muscle mitochondrial DNA density and whole body insulin sensitivity in OLETF rats
    Cheng Ji Jin
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    J Nutr 137:339-44. 2007
    ..752, P<0.001). In conclusion, SAM treatment increased mtDNA density in the skeletal muscle, improved whole body insulin sensitivity, and prevented body weight gain in OLETF rats...
  41. ncbi request reprint Tacrolimus ointment in nickel sulphate-induced steroid-resistant allergic contact dermatitis
    Maria L Pacor
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Verona, Italy
    Allergy Asthma Proc 27:527-31. 2006
    ..No patients withdrew because of burning/itching. In our study, tacrolimus ointment 0.1% appeared to be both effective and safe in the treatment of nickel sulfate-induced steroid-resistant ACD...