Affiliation: University of Verona
Friso S, Udali S, De Santis D, CHOI S. One-carbon metabolism and epigenetics. Mol Aspects Med. 2017;54:28-36 pubmed publisher
..The present review will focus on the link between one-carbon nutrients and epigenetic phenomena based on the current knowledge from findings in cell culture, animal models and human studies. ..
Friso S, Pizzolo F, CHOI S, Guarini P, Castagna A, Ravagnani V, et al
. Epigenetic control of 11 beta-hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension. Atherosclerosis. 2008;199:323-7 pubmed publisher
..Essential hypertensives with elevated urinary THFs/THE ratio also showed higher HSD11B2 promoter methylation. These results show a clear link between the epigenetic regulation through repression of HSD11B2 in PBMC DNA and hypertension. ..
Friso S, Lotto V, CHOI S, Girelli D, Pinotti M, Guarini P, et al
. Promoter methylation in coagulation F7 gene influences plasma FVII concentrations and relates to coronary artery disease. J Med Genet. 2012;49:192-9 pubmed publisher
..011). Epigenetic regulation through methylation of F7 promoter is associated with CAD by affecting plasma FVIIa concentrations in A1A1 genotypes. ..
Friso S, Udali S, Guarini P, Pellegrini C, Pattini P, Moruzzi S, et al
. Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk. Cancer Epidemiol Biomarkers Prev. 2013;22:348-55 pubmed publisher
..This study identifies a threshold for PBMCs-DNA methylation to detect cancer-affected from cancer-free subjects and an at-risk condition for cancer based on genomic DNA methylation and MTHFR677C>T-folate status. ..