Research Topics
Genomes and Genes | A FrigeriSummaryAffiliation: University of Bari Country: Italy Publications
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Publications
Aquaporin-4 deficiency in skeletal muscle and brain of dystrophic mdx miceA Frigeri
Dipartimento di Fisiologia Generale ed Ambientale, Universita degli Studi di Bari, I 70126 Bari, Italy
FASEB J 15:90-98. 2001....- Aquaporins as targets for drug discoveryAntonio Frigeri
Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
Curr Pharm Des 13:2421-7. 2007..Furthermore, strategies that can be developed for the discovery of selective AQP-drugs will be introduced and discussed... 
Dystrophin-dependent and -independent AQP4 pools are expressed in the mouse brainGrazia Paola Nicchia
Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
Glia 56:869-76. 2008..These data provide a better understanding on the association between AQP4 and the dystrophin-glycoprotein complex in the central nervous system...- Aquaporins in skeletal muscle: reassessment of the functional role of aquaporin-4Antonio Frigeri
Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
FASEB J 18:905-7. 2004..These data imply an important role for aquaporins in skeletal muscle physiology as well as an involvement of AQP4 in the molecular alterations that occur in the muscle of DMD patients... 
Effect of microgravity on gene expression in mouse brainAntonio Frigeri
Department of General and Environmental Physiology, Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Via Amendola 165 A, 70126 Bari, Italy
Exp Brain Res 191:289-300. 2008..Furthermore, HU treatment seems to impact on key steps of synaptic plasticity and learning processes...- Altered aquaporin-4 expression in human muscular dystrophies: a common feature?Antonio Frigeri
Dipartimento di Fisiologia Generale ed Ambientale and Centro di Eccellenza in Genomica Comparata, Universita degli Studi di Bari, I 70126 Bari, Italy
FASEB J 16:1120-2. 2002..These experiments provide the first evidence of AQP4 reduction in a human pathology and show that this deficiency is an important feature of DMD/BMD... - Tissue distribution and membrane localization of aquaporin-9 water channel: evidence for sex-linked differences in liverG P Nicchia
Dipartimento di Fisiologia Generale ed Ambientale, Bari, Italy
J Histochem Cytochem 49:1547-56. 2001..AQP9 expression in the osmosensitive region of the brain suggests a role in the mechanism of central osmoreception. All these findings show a unique tissue distribution of AQP9 compared to the other known aquaporins... - Higher order structure of aquaporin-4G P Nicchia
Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, I 70126 Bari, Italy
Neuroscience 168:903-14. 2010.... - The alteration of calcium homeostasis in adult dystrophic mdx muscle fibers is worsened by a chronic exercise in vivoBodvael Fraysse
Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Bari, Italy
Neurobiol Dis 17:144-54. 2004..We provide the first evidence that an in vivo exercise worsens the impaired calcium homeostasis of dystrophic fibers, supporting the role of enhanced calcium entrance in dystrophic progression... - Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuseSabata Pierno
Sezione di Farmacologia, Dipartimento Farmaco-Biologico, , , Italy
Brain 125:1510-21. 2002..Pharmacological modulation of ClC-1 channels may help to prevent disuse-induced muscle impairment... - Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profileJean Francois Desaphy
Unit of Pharmacology, Department of Pharmaco Biology, Faculty of Pharmacy, University of Bari, Bari, I 70125 Italy
Neurobiol Dis 18:356-65. 2005..These results suggest different induction mechanisms for gCl augmentation after the short and long HU periods, as well as a possible role for gCl in the slow muscle adaptation to disuse... - D184E mutation in aquaporin-4 gene impairs water permeability and links to deafnessG P Nicchia
Department of General and Environmental Physiology and Center of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
Neuroscience 197:80-8. 2011..We speculate that this mutation, combined with other genetic defects or concurrently with certain environmental stimuli, could confer a higher susceptibility to deafness... - Microvessel overexpression of aquaporin 1 parallels bone marrow angiogenesis in patients with active multiple myelomaA Vacca
Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University School, Bari, Italy
Br J Haematol 113:415-21. 2001..It may, perhaps, favour angiogenesis in a positive loop and, hence, MM progression, and thus be applied for therapeutic vascular targeting... - In vivo silencing of aquaporin-1 by RNA interference inhibits angiogenesis in the chick embryo chorioallantoic membrane assayG M Camerino
Department of General and Environmental Physiology, University of Bari, Italy
Cell Mol Biol (Noisy-le-grand) 52:51-6. 2006..This is the first study showing the in vivo use of RNA interference technique in the CAM assay. Our results strongly support the hypothesis that AQP1 could have a key role in physiological and pathological angiogenesis... - Effects of chronic treatment with statins and fenofibrate on rat skeletal muscle: a biochemical, histological and electrophysiological studyS Pierno
Department of Pharmacobiology, Section of Pharmacology, Faculty of Pharmacy, University of Bari, Bari, Italy
Br J Pharmacol 149:909-19. 2006.... - The phosphatase inhibitor okadaic acid induces AQP2 translocation independently from AQP2 phosphorylation in renal collecting duct cellsG Valenti
Dipartimento di Fisiologia Generale ed Ambientale, Universita degli Studi, Via Amendola 165 A, Italy
J Cell Sci 113:1985-92. 2000..Thus AQP2 phosphorylation is not essential for water channel translocation in renal cells, indicating that different pathways might exist leading to AQP2 apical insertion and increase in P(f)... - The role of aquaporin-4 in the blood-brain barrier development and integrity: studies in animal and cell culture modelsG P Nicchia
Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics (CEGBA, University of Bari, Via Amendola 165/A, I-70126 Bari, Italy
Neuroscience 129:935-45. 2004..Finally, the role of the endothelial component on AQP4 cellular expression and distribution has been investigated using rat primary astrocytes and brain capillary endothelial cell co-cultures as an in vitro model of BBB... - DNA adducts, benzo(a)pyrene monooxygenase activity, and lysosomal membrane stability in Mytilus galloprovincialis from different areas in Taranto coastal waters (Italy)M Pisoni
Department of General and Environmental Physiology, University of Bari, Via Amendola, 165 A, Bari 70125, Italy
Environ Res 96:163-75. 2004..Overall, the integrated use of biomarkers of exposure and the effects of environmental contaminants on living marine organisms may help to better interpret the impact of pollutants in a marine coastal environment... - Role of aquaporin-4 water channel in the development and integrity of the blood-brain barrierB Nico
Department of Human Anatomy and Histology, University of Bari Medical School, I 70124 Bari, Italy
J Cell Sci 114:1297-307. 2001.... - Altered blood-brain barrier development in dystrophic MDX miceB Nico
Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, I 70124 Bari, Italy
Neuroscience 125:921-35. 2004..These results demonstrate that a reduction in dystrophin isoforms (Dp71) at glial endfeet leads to an altered development of the BBB, whose no-closure might contribute to the neurological dysfunctions associated with DMD... - A multidisciplinary evaluation of the effectiveness of cyclosporine a in dystrophic mdx miceAnnamaria De Luca
Sezione di Farmacologia, Dipartimento Farmacobiologico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, Campus, 70125 Bari, Italy
Am J Pathol 166:477-89. 2005..The beneficial effect of CsA may involve different targets, reinforcing the usefulness of immunosuppressant drugs in muscular dystrophy... - Actin cytoskeleton remodeling governs aquaporin-4 localization in astrocytesGrazia Paola Nicchia
Department of General and Environmental Physiology, Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
Glia 56:1755-66. 2008..Finally, AQP4 knockdown does not compromise the ability of astrocytes to stellate in the presence of cAMP, indicating that astrocyte stellation is independent of AQP4... - Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscleAnnamaria De Luca
Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Italy
Neurobiol Dis 32:243-53. 2008.... - Aquaporin-1 expression in the chick embryo chorioallantoic membraneDomenico Ribatti
Department of Human Anatomy and Histology, University of Bari Medical School, Piaza Giulio Cesare, 11 Policlinico, I 70124 Bari, Italy
Anat Rec 268:85-9. 2002.... - The KATP channel is a molecular sensor of atrophy in skeletal muscleDomenico Tricarico
Pharmacobiology Department, Faculty of Pharmacy, University of Bari, via Orabona no 4, 70120 Bari, Italy
J Physiol 588:773-84. 2010..2 and SUR2B, or their in vitro pharmacological blockade activates atrophic signalling in skeletal muscle. All these findings suggest a new role for the K(ATP) channel as a molecular sensor of atrophy... - New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43Grazia P Nicchia
Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
FASEB J 19:1674-6. 2005..Finally, the strong down-regulation of Cx43 and cell coupling in AQP4 KD mouse astrocytes indicate that a functional relationship likely exists between water channels and gap junctions in brain astrocytes... - Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx miceBeatrice Nico
Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
Glia 42:235-51. 2003..The BBB alterations suggest that changes in vascular permeability are involved in the pathogenesis of the neurological dysfunction associated with DMD... - Inhibition of aquaporin-4 expression in astrocytes by RNAi determines alteration in cell morphology, growth, and water transport and induces changes in ischemia-related genesGrazia Paola Nicchia
Department of General and Environmental Physiology and Center of Excellence in Comparative Genomics (CEGBA, University of Bari, I-70126 Bari, Italy
FASEB J 17:1508-10. 2003.... - Aquaporin-4 expression during development of the cerebellumBeatrice Nico
Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
Cerebellum 1:207-12. 2002..Overall, the data clearly indicate a close relationship between blood-brain barrier functioning and the control of water flux by astroglial cells and the crucial role played by AQP4 in this setting... - Different pattern of aquaporin-4 expression in extensor digitorum longus and soleus during early developmentGrazia P Nicchia
Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Via Amendola 165 A, I 70126 Bari, Italy
Muscle Nerve 35:625-31. 2007..The results suggest that AQP4 expression in skeletal muscle is under neuronal influence and contribute to the understanding of the molecular events of fiber differentiation during development... - Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodiesGrazia Paola Nicchia
Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
Glia 57:1363-73. 2009..Finally, water transport measurements show that NMO-IgG treatment does not significantly affect AQP4 function. In conclusion, our results suggest for the first time that OAP assemblies are required for NMO-IgG to recognize AQP4... - Evidences for a leaky scanning mechanism for the synthesis of the shorter M23 protein isoform of aquaporin-4: implication in orthogonal array formation and neuromyelitis optica antibody interactionAndrea Rossi
Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics, University of Bari, Bari 70125, Italy
J Biol Chem 285:4562-9. 2010..In this study we also provide evidence that AQP4-M1 is mobile in the plasma membrane, that it is inserted and not excluded into immobile OAPs, and that it is an important determinant of OAP structure and size... - Serum and CSF N-acetyl aspartate levels differ in multiple sclerosis and neuromyelitis opticaC Tortorella
Department of Neurological and Psychiatric Sciences, University of Bari, Italy
J Neurol Neurosurg Psychiatry 82:1355-9. 2011.... - Automated cell-based assay for screening of aquaporin inhibitorsMaria Grazia Mola
Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, I 70126 Bari, Italy
Anal Chem 81:8219-29. 2009.... - Functional down-regulation of volume-regulated anion channels in AQP4 knockdown cultured rat cortical astrocytesValentina Benfenati
Department of Human and General Physiology, University of Bologna, Bologna, Italy
J Neurochem 100:87-104. 2007..Collectively, these results support the view that in cultured astroglial cells, plasma membrane proteins involved in cell volume homeostasis are assembled in a functional platform... - Aquaporin-4 expression is severely reduced in human sarcoglycanopathies and dysferlinopathiesStefania Assereto
Muscular and Neurodegenerative Disease Unit, Department of Pediatrics of University of Genova, Department of Neuroscience and Rehabilitation, G Gaslini Institute, Genoa, Italy
Cell Cycle 7:2199-207. 2008..In conclusion, AQP4 expression and membrane localization are markedly reduced in LGMD 2B-2F. The role of AQP4 in the degenerative mechanism occurring in these diseases will be the object of our future research... - A developmental switch in the expression of aquaporin-4 and Kir4.1 from horizontal to Müller cells in mouse retinaAlejandra Bosco
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Invest Ophthalmol Vis Sci 46:3869-75. 2005..This study was conducted to determine the presence of AQP4 and Kir4.1 proteins in the developing mouse retina...