Research Topics
| Giada FrenzilliSummaryAffiliation: University of Pisa Country: Italy Publications
| Collaborators
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Detail Information
Publications
The Comet assay for the evaluation of genotoxic impact in aquatic environmentsG Frenzilli
Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
Mutat Res 681:80-92. 2009..Standardization and inter-laboratory calibration of the Comet assay as applied to aquatic species will be required if the Comet assay is to be used routinely by national bodies charged with monitoring water quality...
The comet assay as a method of assessment of neurotoxicity: usefulness for drugs of abuseGiada Frenzilli
Dipartimento di Morfologia Umana, E Biologia Applicata, Universita di Pisa, Via Volta, 4, I 56126 Pisa, Italy
Ann N Y Acad Sci 1074:478-81. 2006..The present article summarizes some data from our and other groups underlining the suitability of the Comet assay in assessing neurotoxicity and its potential in evaluating drugs of abuse-related genotoxicity...- Cellular responses in the cyprinid Leuciscus cephalus from a contaminated freshwater ecosystemG Frenzilli
Dipartimento di Morfologia Umana e Biologia Applicata, Sezione di Biologia e Genetica, Universita di Pisa, Pisa, Italy
Aquat Toxicol 89:188-96. 2008..This study confirmed the utility of large batteries of biomarkers in biomonitoring studies and the suitability of wild chub as bioindicator organism for river basins... 
Effects of loud noise exposure on DNA integrity in rat adrenal glandGiada Frenzilli
Dipartimento di Morfologia Umana e Biologia Applicata, University of Pisa, Pisa, Italy
Environ Health Perspect 112:1671-2. 2004..Genetic alterations did not decrease 24 hr after the cessation of the stimulus. We hypothesize that an imbalance of redox cell status is responsible for the induction and persistence of noise-induced cellular damage...- DNA damage in eelpout (Zoarces viviparus) from Göteborg harbourGiada Frenzilli
Department of Human Morphology and Applied Biology, University of Pisa, Via Volta 4, 56126 Pisa, Italy
Mutat Res 552:187-95. 2004..The levels of apoptic cells did not show any marked variations, but a significant recovery was observed in fish from the oil impacted site 5 months after the spill... - Antioxidant, genotoxic and lysosomal biomarkers in the freshwater bivalve (Unio pictorum) transplanted in a metal polluted river basinPatrizia Guidi
Dipartimento di Morfologia Umana e Biologia Applicata, Sezione Biologia e Genetica, Universita di Pisa, Via A Volta 4, 56126 Pisa, Italy
Aquat Toxicol 100:75-83. 2010.... - Genotoxic effects of produced waters in mosquito fish (Gambusia affinis)Ilaria Caliani
Department of Environmental Sciences, University of Siena, Via Mattioli, 4, 53100, Siena, Italy
Ecotoxicology 18:75-80. 2009..A positive correlation between presence of micronucleated cells and PAH metabolites in bile was also observed... - Time-course evaluation of ROS-mediated toxicity in mussels, Mytilus galloprovincialis, during a field translocation experimentGiada Frenzilli
Dipartimento di Morfologia Umana e Biologia Applicata, , Italy
Mar Environ Res 58:609-13. 2004..Results showed a biphasic trend for single antioxidants and TOSC, with an increase during the first 2 weeks of exposure to the polluted site followed by a progressive decrease up to a severe depletion in the final part of the experiment... - DNA fragmentation and oxidative stress in the hippocampal formation: a bridge between 3,4-methylenedioxymethamphetamine (ecstasy) intake and long-lasting behavioral alterationsGiada Frenzilli
Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
Behav Pharmacol 18:471-81. 2007..The present data indicate that the intake of very low doses of MDMA, comparable to those consumed by humans, produces selective hippocampal alterations which may underlie cognitive impairment and seizure susceptibility... - DNA damage associated with ultrastructural alterations in rat myocardium after loud noise exposurePaola Lenzi
Dipartimento di Morfologia Umana e Biologia Applicata, University of Pisa, Pisa, Italy
Environ Health Perspect 111:467-71. 2003..An elevated oxyradical generation, possibly related to altered sympathetic innervation, is hypothesized as responsible for the induction and persistence of noise-induced cellular damage... - Genotoxic potential of TiO2 on bottlenose dolphin leukocytesMargherita Bernardeschi
Dipartimento di Morfologia Umana e Biologia Applicata, University of Pisa, Via Volta 4, 56126 Pisa, Italy
Anal Bioanal Chem 396:619-23. 2010..Although preliminary, these are the first data regarding the genetic susceptibility of toothed cetaceans toward an "emerging" pollutant, such as TiO(2) particles... - Genotoxicity of amorphous silica particles with different structure and dimension in human and murine cell linesPatrizia Guidi
Dipartimento di Medicina Clinica e Sperimentale, Unità di Biologia applicata e Genetica, Universita di Pisa, Via A Volta 4, 56126 Pisa, Italy
Mutagenesis 28:171-80. 2013..The cytotoxic response of RAW264.7 was particularly relevant after MCM-41 exposure. The genotoxicity of amorphous silica highlights the need for a proper assessment of its potential hazard for human health... - MDMA induces caspase-3 activation in the limbic system but not in striatumIlaria Tamburini
Department of Human Morphology and Applied Biology, Univerity of Pisa, Via Roma 55, 56126 Pisa, Italy
Ann N Y Acad Sci 1074:377-81. 2006..Potential implications and pitfalls of such an experimental observation are reported... - Cytogenetic and oxidative damage induced in human lymphocytes by platinum, rhodium and palladium compoundsLucia Migliore
Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
Mutagenesis 17:411-7. 2002..This work highlights the stronger genotoxicity, likely mediated by oxidative damage induction, of Pt and Rh compounds compared with Pd salts... - Genotoxicity biomarkers in Mytilus galloprovincialis: wild versus caged musselsClaudia Bolognesi
Environmental Carcinogenesis Unit, National Cancer Research Institute, Largo R Benzi 10, 16132 Genova, Italy
Mutat Res 552:153-62. 2004..Endogenous and exogenous factors, such as change of pollutant input levels or compositions, could be considered the cause of such variability... - Time-course variations of oxyradical metabolism, DNA integrity and lysosomal stability in mussels, Mytilus galloprovincialis, during a field translocation experimentFrancesco Regoli
Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
Aquat Toxicol 68:167-78. 2004.... - Integrating enzymatic responses to organic chemical exposure with total oxyradical absorbing capacity and DNA damage in the European eel Anguilla anguillaFrancesco Regoli
Istituto di Biologia e Genetica, Universita Politecnica delle Marche, 60100 Ancona, Italy
Environ Toxicol Chem 22:2120-9. 2003..These data suggest a general relationship between oxidative stress and loss of DNA integrity in juvenile eels exposed to the chemicals studied herein...