Giada Frenzilli

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi request reprint The comet assay as a method of assessment of neurotoxicity: usefulness for drugs of abuse
    Giada Frenzilli
    Dipartimento di Morfologia Umana, E Biologia Applicata, Universita di Pisa, Via Volta, 4, I 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:478-81. 2006
  2. ncbi request reprint Cellular responses in the cyprinid Leuciscus cephalus from a contaminated freshwater ecosystem
    G Frenzilli
    Dipartimento di Morfologia Umana e Biologia Applicata, Sezione di Biologia e Genetica, Universita di Pisa, Pisa, Italy
    Aquat Toxicol 89:188-96. 2008
  3. doi request reprint The Comet assay for the evaluation of genotoxic impact in aquatic environments
    G Frenzilli
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Mutat Res 681:80-92. 2009
  4. pmc Effects of loud noise exposure on DNA integrity in rat adrenal gland
    Giada Frenzilli
    Dipartimento di Morfologia Umana e Biologia Applicata, University of Pisa, Pisa, Italy
    Environ Health Perspect 112:1671-2. 2004
  5. ncbi request reprint DNA damage in eelpout (Zoarces viviparus) from Göteborg harbour
    Giada Frenzilli
    Department of Human Morphology and Applied Biology, University of Pisa, Via Volta 4, 56126 Pisa, Italy
    Mutat Res 552:187-95. 2004
  6. ncbi request reprint Antioxidant, genotoxic and lysosomal biomarkers in the freshwater bivalve (Unio pictorum) transplanted in a metal polluted river basin
    Patrizia Guidi
    Dipartimento di Morfologia Umana e Biologia Applicata, Sezione Biologia e Genetica, Universita di Pisa, Via A Volta 4, 56126 Pisa, Italy
    Aquat Toxicol 100:75-83. 2010
  7. doi request reprint Genotoxic effects of produced waters in mosquito fish (Gambusia affinis)
    Ilaria Caliani
    Department of Environmental Sciences, University of Siena, Via Mattioli, 4, 53100, Siena, Italy
    Ecotoxicology 18:75-80. 2009
  8. ncbi request reprint Genotoxicity of amorphous silica particles with different structure and dimension in human and murine cell lines
    Patrizia Guidi
    Dipartimento di Medicina Clinica e Sperimentale, Unità di Biologia applicata e Genetica, Universita di Pisa, Via A Volta 4, 56126 Pisa, Italy
    Mutagenesis 28:171-80. 2013
  9. ncbi request reprint Time-course evaluation of ROS-mediated toxicity in mussels, Mytilus galloprovincialis, during a field translocation experiment
    Giada Frenzilli
    Dipartimento di Morfologia Umana e Biologia Applicata, Universita di Pisa, Italy
    Mar Environ Res 58:609-13. 2004
  10. ncbi request reprint DNA fragmentation and oxidative stress in the hippocampal formation: a bridge between 3,4-methylenedioxymethamphetamine (ecstasy) intake and long-lasting behavioral alterations
    Giada Frenzilli
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Behav Pharmacol 18:471-81. 2007

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The comet assay as a method of assessment of neurotoxicity: usefulness for drugs of abuse
    Giada Frenzilli
    Dipartimento di Morfologia Umana, E Biologia Applicata, Universita di Pisa, Via Volta, 4, I 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:478-81. 2006
    ..The present article summarizes some data from our and other groups underlining the suitability of the Comet assay in assessing neurotoxicity and its potential in evaluating drugs of abuse-related genotoxicity...
  2. ncbi request reprint Cellular responses in the cyprinid Leuciscus cephalus from a contaminated freshwater ecosystem
    G Frenzilli
    Dipartimento di Morfologia Umana e Biologia Applicata, Sezione di Biologia e Genetica, Universita di Pisa, Pisa, Italy
    Aquat Toxicol 89:188-96. 2008
    ..This study confirmed the utility of large batteries of biomarkers in biomonitoring studies and the suitability of wild chub as bioindicator organism for river basins...
  3. doi request reprint The Comet assay for the evaluation of genotoxic impact in aquatic environments
    G Frenzilli
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Mutat Res 681:80-92. 2009
    ..Standardization and inter-laboratory calibration of the Comet assay as applied to aquatic species will be required if the Comet assay is to be used routinely by national bodies charged with monitoring water quality...
  4. pmc Effects of loud noise exposure on DNA integrity in rat adrenal gland
    Giada Frenzilli
    Dipartimento di Morfologia Umana e Biologia Applicata, University of Pisa, Pisa, Italy
    Environ Health Perspect 112:1671-2. 2004
    ..Genetic alterations did not decrease 24 hr after the cessation of the stimulus. We hypothesize that an imbalance of redox cell status is responsible for the induction and persistence of noise-induced cellular damage...
  5. ncbi request reprint DNA damage in eelpout (Zoarces viviparus) from Göteborg harbour
    Giada Frenzilli
    Department of Human Morphology and Applied Biology, University of Pisa, Via Volta 4, 56126 Pisa, Italy
    Mutat Res 552:187-95. 2004
    ..The levels of apoptic cells did not show any marked variations, but a significant recovery was observed in fish from the oil impacted site 5 months after the spill...
  6. ncbi request reprint Antioxidant, genotoxic and lysosomal biomarkers in the freshwater bivalve (Unio pictorum) transplanted in a metal polluted river basin
    Patrizia Guidi
    Dipartimento di Morfologia Umana e Biologia Applicata, Sezione Biologia e Genetica, Universita di Pisa, Via A Volta 4, 56126 Pisa, Italy
    Aquat Toxicol 100:75-83. 2010
    ....
  7. doi request reprint Genotoxic effects of produced waters in mosquito fish (Gambusia affinis)
    Ilaria Caliani
    Department of Environmental Sciences, University of Siena, Via Mattioli, 4, 53100, Siena, Italy
    Ecotoxicology 18:75-80. 2009
    ..A positive correlation between presence of micronucleated cells and PAH metabolites in bile was also observed...
  8. ncbi request reprint Genotoxicity of amorphous silica particles with different structure and dimension in human and murine cell lines
    Patrizia Guidi
    Dipartimento di Medicina Clinica e Sperimentale, Unità di Biologia applicata e Genetica, Universita di Pisa, Via A Volta 4, 56126 Pisa, Italy
    Mutagenesis 28:171-80. 2013
    ..The cytotoxic response of RAW264.7 was particularly relevant after MCM-41 exposure. The genotoxicity of amorphous silica highlights the need for a proper assessment of its potential hazard for human health...
  9. ncbi request reprint Time-course evaluation of ROS-mediated toxicity in mussels, Mytilus galloprovincialis, during a field translocation experiment
    Giada Frenzilli
    Dipartimento di Morfologia Umana e Biologia Applicata, Universita di Pisa, Italy
    Mar Environ Res 58:609-13. 2004
    ..Results showed a biphasic trend for single antioxidants and TOSC, with an increase during the first 2 weeks of exposure to the polluted site followed by a progressive decrease up to a severe depletion in the final part of the experiment...
  10. ncbi request reprint DNA fragmentation and oxidative stress in the hippocampal formation: a bridge between 3,4-methylenedioxymethamphetamine (ecstasy) intake and long-lasting behavioral alterations
    Giada Frenzilli
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Behav Pharmacol 18:471-81. 2007
    ..The present data indicate that the intake of very low doses of MDMA, comparable to those consumed by humans, produces selective hippocampal alterations which may underlie cognitive impairment and seizure susceptibility...
  11. pmc DNA damage associated with ultrastructural alterations in rat myocardium after loud noise exposure
    Paola Lenzi
    Dipartimento di Morfologia Umana e Biologia Applicata, University of Pisa, Pisa, Italy
    Environ Health Perspect 111:467-71. 2003
    ..An elevated oxyradical generation, possibly related to altered sympathetic innervation, is hypothesized as responsible for the induction and persistence of noise-induced cellular damage...
  12. ncbi request reprint Genotoxic potential of TiO2 on bottlenose dolphin leukocytes
    Margherita Bernardeschi
    Dipartimento di Morfologia Umana e Biologia Applicata, University of Pisa, Via Volta 4, 56126 Pisa, Italy
    Anal Bioanal Chem 396:619-23. 2010
    ..Although preliminary, these are the first data regarding the genetic susceptibility of toothed cetaceans toward an "emerging" pollutant, such as TiO(2) particles...
  13. ncbi request reprint MDMA induces caspase-3 activation in the limbic system but not in striatum
    Ilaria Tamburini
    Department of Human Morphology and Applied Biology, Univerity of Pisa, Via Roma 55, 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:377-81. 2006
    ..Potential implications and pitfalls of such an experimental observation are reported...
  14. doi request reprint The comet assay in marine animals
    Giada Frenzilli
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    Methods Mol Biol 1044:363-72. 2013
    ..Here we describe the protocols for the single-cell gel electrophoresis (Comet) assay in its alkaline (pH > 13), mild alkaline (pH = 12.1), and neutral (pH = 8) versions, when applied in marine animals. ..
  15. ncbi request reprint Cytogenetic and oxidative damage induced in human lymphocytes by platinum, rhodium and palladium compounds
    Lucia Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 17:411-7. 2002
    ..This work highlights the stronger genotoxicity, likely mediated by oxidative damage induction, of Pt and Rh compounds compared with Pd salts...
  16. ncbi request reprint Renal vasodilating capacity and endothelial function are impaired in patients with obstructive sleep apnea syndrome and no traditional cardiovascular risk factors
    Rosa M Bruno
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    J Hypertens 31:1456-64; discussion 1464. 2013
    ..Aim of the study was to investigate whether vascular dysfunction is a feature of obstructive sleep apnea syndrome per se or instead related to the presence of traditional cardiovascular risk factors...
  17. ncbi request reprint Genotoxicity biomarkers in Mytilus galloprovincialis: wild versus caged mussels
    Claudia Bolognesi
    Environmental Carcinogenesis Unit, National Cancer Research Institute, Largo R Benzi 10, 16132 Genova, Italy
    Mutat Res 552:153-62. 2004
    ..Endogenous and exogenous factors, such as change of pollutant input levels or compositions, could be considered the cause of such variability...
  18. ncbi request reprint Time-course variations of oxyradical metabolism, DNA integrity and lysosomal stability in mussels, Mytilus galloprovincialis, during a field translocation experiment
    Francesco Regoli
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri Monte d Ago, 60100 Ancona, Italy
    Aquat Toxicol 68:167-78. 2004
    ....
  19. ncbi request reprint Integrating enzymatic responses to organic chemical exposure with total oxyradical absorbing capacity and DNA damage in the European eel Anguilla anguilla
    Francesco Regoli
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, 60100 Ancona, Italy
    Environ Toxicol Chem 22:2120-9. 2003
    ..These data suggest a general relationship between oxidative stress and loss of DNA integrity in juvenile eels exposed to the chemicals studied herein...