Alessandra Fraternale

Summary

Affiliation: University of Urbino
Country: Italy

Publications

  1. ncbi request reprint Effect of the N-butanoyl glutathione (GSH) derivative and acyclovir on HSV-1 replication and Th1 cytokine expression in human macrophages
    Alessandra Fraternale
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi, 2, 61029, Urbino, PU, Italy
    Med Microbiol Immunol 203:283-9. 2014
  2. pmc Molecules altering the intracellular thiol content modulate NF-kB and STAT-1/IRF-1 signalling pathways and IL-12 p40 and IL-27 p28 production in murine macrophages
    Alessandra Fraternale
    Department of Biomolecular Sciences University of Urbino Carlo Bo, Urbino PU, Italy
    PLoS ONE 8:e57866. 2013
  3. doi request reprint Modulation of Th1/Th2 immune responses to HIV-1 Tat by new pro-GSH molecules
    Alessandra Fraternale
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi, 2, 61029 Urbino PU, Italy
    Vaccine 29:6823-9. 2011
  4. ncbi request reprint The increase in intra-macrophage thiols induced by new pro-GSH molecules directs the Th1 skewing in ovalbumin immunized mice
    Alessandra Fraternale
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi, 2, 61029 Urbino PU, Italy
    Vaccine 28:7676-82. 2010
  5. doi request reprint Erythrocytes as carriers of antisense PNA addressed against HIV-1 gag-pol transframe domain
    Alessandra Fraternale
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, PU, Italy
    J Drug Target 17:278-85. 2009
  6. doi request reprint GSH and analogs in antiviral therapy
    Alessandra Fraternale
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, PU, Italy
    Mol Aspects Med 30:99-110. 2009
  7. ncbi request reprint Antitumoral activity of indole-3-carbinol cyclic tri- and tetrameric derivatives mixture in human breast cancer cells: in vitro and in vivo studies
    Giorgio Brandi
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino PU, Italy
    Anticancer Agents Med Chem 13:654-62. 2013
  8. ncbi request reprint Drug-loaded red blood cell-mediated clearance of HIV-1 macrophage reservoir by selective inhibition of STAT1 expression
    Mauro Magnani
    Institute of Biochemistry G Fornaini University of Urbino, Via Saffi 2, 61029, Urbino, Italy
    J Leukoc Biol 74:764-71. 2003
  9. ncbi request reprint Comparison of novel delivery systems for antisense peptide nucleic acids
    Laura Chiarantini
    Institute of Biochemistry Giorgio Fornaini, University of Urbino Carlo Bo, Italy
    J Control Release 109:24-36. 2005
  10. ncbi request reprint A new one-step RT-PCR method for virus quantitation in murine AIDS
    Anna Casabianca
    Institute of Biological Chemistry Giorgio Fornaini, University of Urbino, Via Saffi, 2, 61029 PU, Urbino, Italy
    J Virol Methods 110:81-90. 2003

Detail Information

Publications16

  1. ncbi request reprint Effect of the N-butanoyl glutathione (GSH) derivative and acyclovir on HSV-1 replication and Th1 cytokine expression in human macrophages
    Alessandra Fraternale
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi, 2, 61029, Urbino, PU, Italy
    Med Microbiol Immunol 203:283-9. 2014
    ..Nonetheless, lower levels of IL-12 p40 and IL-27 p28 proteins were found in the supernatants of macrophages treated with either GSH-C4 or ACV, likely as an indirect consequence of inhibited HSV-1 replication. ..
  2. pmc Molecules altering the intracellular thiol content modulate NF-kB and STAT-1/IRF-1 signalling pathways and IL-12 p40 and IL-27 p28 production in murine macrophages
    Alessandra Fraternale
    Department of Biomolecular Sciences University of Urbino Carlo Bo, Urbino PU, Italy
    PLoS ONE 8:e57866. 2013
    ..We had already demonstrated that GSH-C4 and I-152 could shift the immune response towards Th1 in Ovalbumin-immunized mice as well as enhance Th1 response in HIV-1 Tat-immunized mice...
  3. doi request reprint Modulation of Th1/Th2 immune responses to HIV-1 Tat by new pro-GSH molecules
    Alessandra Fraternale
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi, 2, 61029 Urbino PU, Italy
    Vaccine 29:6823-9. 2011
    ....
  4. ncbi request reprint The increase in intra-macrophage thiols induced by new pro-GSH molecules directs the Th1 skewing in ovalbumin immunized mice
    Alessandra Fraternale
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi, 2, 61029 Urbino PU, Italy
    Vaccine 28:7676-82. 2010
    ....
  5. doi request reprint Erythrocytes as carriers of antisense PNA addressed against HIV-1 gag-pol transframe domain
    Alessandra Fraternale
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, PU, Italy
    J Drug Target 17:278-85. 2009
    ....
  6. doi request reprint GSH and analogs in antiviral therapy
    Alessandra Fraternale
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, PU, Italy
    Mol Aspects Med 30:99-110. 2009
    ..Several reports have provided evidence for the use of GSH and molecules able to replenish intracellular GSH levels in antiviral therapy. This non-conventional role of GSH and its analogs as antiviral drugs is discussed in this chapter...
  7. ncbi request reprint Antitumoral activity of indole-3-carbinol cyclic tri- and tetrameric derivatives mixture in human breast cancer cells: in vitro and in vivo studies
    Giorgio Brandi
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino PU, Italy
    Anticancer Agents Med Chem 13:654-62. 2013
    ..Our data indicate that CTr/CTet is a potential anticancer combination agent for both hormone-responsive and triple-negative breast tumors...
  8. ncbi request reprint Drug-loaded red blood cell-mediated clearance of HIV-1 macrophage reservoir by selective inhibition of STAT1 expression
    Mauro Magnani
    Institute of Biochemistry G Fornaini University of Urbino, Via Saffi 2, 61029, Urbino, Italy
    J Leukoc Biol 74:764-71. 2003
    ..Taken together, the evidence of HIV-1-induced increase of STAT1, and the availability of a selective drug targeting system, may prove useful in the design of new pharmacological treatments to clear the HIV-1 macrophage reservoir...
  9. ncbi request reprint Comparison of novel delivery systems for antisense peptide nucleic acids
    Laura Chiarantini
    Institute of Biochemistry Giorgio Fornaini, University of Urbino Carlo Bo, Italy
    J Control Release 109:24-36. 2005
    ..Both delivery through polymeric microspheres and encapsulation into erythrocytes allowed the antisense activity of unmodified PNAs at nanomolar concentration...
  10. ncbi request reprint A new one-step RT-PCR method for virus quantitation in murine AIDS
    Anna Casabianca
    Institute of Biological Chemistry Giorgio Fornaini, University of Urbino, Via Saffi, 2, 61029 PU, Urbino, Italy
    J Virol Methods 110:81-90. 2003
    ....
  11. ncbi request reprint Repeated cycles of alternate administration of fludarabine and Zidovudine plus Didanosine inhibits murine AIDS and reduces proviral DNA content in lymph nodes to undetectable levels
    Alessandra Fraternale
    Institute of Biological Chemistry Giorgio Fornaini, University of Urbino, 61029 Urbino, Italy
    Virology 302:354-62. 2002
    ..This study suggests that optimized protocols of alternate administration of cytolytic and antiretroviral drugs may represent a useful strategy to eradicate retroviral infections...
  12. doi request reprint Drug delivery by red blood cells
    Sara Biagiotti
    Department of Biomolecular Sciences, University of Urbino, Italy
    IUBMB Life 63:621-31. 2011
    ..This new modality is not yet fully developed and explored but will certainly provide a technical solution to the problem of stabilizing drug concentration in circulation improving drug efficacy and reducing drug toxicity...
  13. ncbi request reprint Synthesis and biological evaluation of a gamma-cyclodextrin-based formulation of the anticancer agent 5,6,11,12,17,18,23,24-octahydrocyclododeca[1,2-b:4,5-b':7,8-b'':10,11-b''']tetraindole (CTet)
    Simone Lucarini
    Dipartimento di Scienze del Farmaco e della Salute, Università degli Studi di Urbino Carlo Bo I 61029 Urbino, Piazza del Rinascimento 6, Italy
    Molecules 15:4085-93. 2010
    ..20 +/- 0.04 microM and 1.0 +/- 0.1 microM, respectively)...
  14. ncbi request reprint Inhibition of macrophage iNOS by selective targeting of antisense PNA
    Laura Chiarantini
    Institute of Biochemistry Giorgio Fornaini Università degli Studi di Urbino, Italy
    Biochemistry 41:8471-7. 2002
    ..72 pmol/10(6) macrophages). The efficacy of this delivery system is demonstrated by decreases in NO production and iNOS protein expression inside the macrophage. Therefore, we can suggest this novel approach for biomedical application...
  15. pmc The indole-3-carbinol cyclic tetrameric derivative CTet inhibits cell proliferation via overexpression of p21/CDKN1A in both estrogen receptor-positive and triple-negative breast cancer cell lines
    Mauro De Santi
    Department of Biomolecular Sciences, University of Urbino Carlo Bo, Via Saffi 2, 61029 Urbino, Italy
    Breast Cancer Res 13:R33. 2011
    ..This study aims to analyze the mechanisms involved in the in vitro inhibition of cell proliferation and to evaluate the in vivo antitumor activity of CTet in a xenograft study...
  16. ncbi request reprint Species-dependent chromium accumulation, lipid peroxidation, and glutathione levels in germinating kiwifruit pollen under Cr(III) and Cr(VI) stress
    Valeria Scoccianti
    Istituto di Botanica, Universita di Urbino Carlo Bo, Via Bramante 28, 61029 Urbino, Italy
    Chemosphere 73:1042-8. 2008
    ....