M Franchini

Summary

Affiliation: University of Verona
Country: Italy

Publications

  1. ncbi Haemostasis and pregnancy
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Ospedale Policlinico, Piazzale L Scuro, 10, 37134 Verona, Italy
    Thromb Haemost 95:401-13. 2006
  2. ncbi Pathogenesis, clinical and laboratory aspects of thrombosis in cancer
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azinda ospedaliera de Verona, Ospedale Policlinico, Piazzale Ludovico Scuro, 37134, Verona, Italy
    J Thromb Thrombolysis 24:29-38. 2007
  3. ncbi Drug-induced anti-factor VIII antibodies: a systematic review
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Med Sci Monit 13:RA55-61. 2007
  4. ncbi The role of von Willebrand factor in hemorrhagic and thrombotic disorders
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Crit Rev Clin Lab Sci 44:115-49. 2007
  5. ncbi Is time to treat for HCV all the HIV/HCV co-infected hemophiliacs?
    Massimo Franchini
    Hemophilia Center, City Hospital of Verona, Verona, Italy
    Hematology 11:209-13. 2006
  6. ncbi Rituximab for the treatment of childhood chronic idiopathic thrombocytopenic purpura and hemophilia with inhibitors
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Pediatr Blood Cancer 49:6-10. 2007
  7. ncbi Recent acquisitions in acquired and congenital von Willebrand disorders
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera Policlinico, Piazzale L Scuro, and Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Universita di Verona, Italy
    Clin Chim Acta 377:62-9. 2007
  8. ncbi Acquired von Willebrand syndrome: an update
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Am J Hematol 82:368-75. 2007
  9. ncbi [Acquired von Willebrand syndrome]
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera, Verona
    Recenti Prog Med 97:417-21; quiz 440. 2006
  10. ncbi The efficacy of rituximab in the treatment of inhibitor-associated hemostatic disorders
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Ospedaliera di Verona, Verona, Italy
    Thromb Haemost 96:119-25. 2006

Detail Information

Publications115 found, 100 shown here

  1. ncbi Haemostasis and pregnancy
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Ospedale Policlinico, Piazzale L Scuro, 10, 37134 Verona, Italy
    Thromb Haemost 95:401-13. 2006
    ..Based on an analysis of the literature data, this review presents an overview of the main thrombotic and haemorrhagic disorders complicating pregnancy...
  2. ncbi Pathogenesis, clinical and laboratory aspects of thrombosis in cancer
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azinda ospedaliera de Verona, Ospedale Policlinico, Piazzale Ludovico Scuro, 37134, Verona, Italy
    J Thromb Thrombolysis 24:29-38. 2007
    ..In this review article, we briefly analyze the pathogenesis, laboratory, clinical and therapeutic features of cancer and thrombosis...
  3. ncbi Drug-induced anti-factor VIII antibodies: a systematic review
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Med Sci Monit 13:RA55-61. 2007
    ..3%). However, further studies are needed to better elucidate the epidemiology, natural history, clinical relevance, and optimal treatment of drug-associated factor VIII autoantibodies...
  4. ncbi The role of von Willebrand factor in hemorrhagic and thrombotic disorders
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Crit Rev Clin Lab Sci 44:115-49. 2007
    ..The role of VWF in normal and pathological hemostasis is discussed in this review, and important advances in the pathophysiology, diagnosis, and treatment of VWF-associated disorders are also described...
  5. ncbi Is time to treat for HCV all the HIV/HCV co-infected hemophiliacs?
    Massimo Franchini
    Hemophilia Center, City Hospital of Verona, Verona, Italy
    Hematology 11:209-13. 2006
    ..In this concise review, the current knowledge as regards the management of HCV infection in HIV co-infected hemophiliacs is analyzed...
  6. ncbi Rituximab for the treatment of childhood chronic idiopathic thrombocytopenic purpura and hemophilia with inhibitors
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Pediatr Blood Cancer 49:6-10. 2007
    ..Therefore, large, prospective, and randomized trials are needed to confirm the positive, preliminary results...
  7. ncbi Recent acquisitions in acquired and congenital von Willebrand disorders
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera Policlinico, Piazzale L Scuro, and Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Universita di Verona, Italy
    Clin Chim Acta 377:62-9. 2007
    ..Its deficiency is associated with a bleeding tendency. The progresses in the pathophysiology, diagnosis and management of inherited von Willebrand disease and acquired von Willebrand syndrome will be discussed in this review...
  8. ncbi Acquired von Willebrand syndrome: an update
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Am J Hematol 82:368-75. 2007
    ..Through an analysis of the more recent literature data, the pathophysiology and the clinical, laboratory, and therapeutic aspects of this syndrome are concisely reported in this review...
  9. ncbi [Acquired von Willebrand syndrome]
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera, Verona
    Recenti Prog Med 97:417-21; quiz 440. 2006
    ..The main pathogenic, clinical, laboratory and therapeutic aspects of this syndrome are concisely reported in this review...
  10. ncbi The efficacy of rituximab in the treatment of inhibitor-associated hemostatic disorders
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Ospedaliera di Verona, Verona, Italy
    Thromb Haemost 96:119-25. 2006
    ..Large, prospective, randomized trials are, therefore, needed to confirm the positive, preliminary results...
  11. ncbi Postpartum acquired factor VIII inhibitors
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Am J Hematol 81:768-73. 2006
    ..Based on an analysis of the literature, this review presents the current knowledge on the pathogenesis, diagnosis, epidemiology, natural history, clinical manifestations, and therapeutic management of postpartum acquired hemophilia A...
  12. ncbi The use of desmopressin as a hemostatic agent: a concise review
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Am J Hematol 82:731-5. 2007
    ..This review briefly summarizes the current clinical indications on the use of desmopressin as a hemostatic agent...
  13. ncbi Efficacy of desmopressin in preventing hemorrhagic complications in a patient with Marfan syndrome undergoing cardiac surgery
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Blood Coagul Fibrinolysis 17:325-6. 2006
    ..In this case report, we describe the successful use of desmopressin as prophylaxis against hemorrhage in a patient with a bleeding tendency associated with Marfan syndrome and a platelet function defect undergoing cardiovascular surgery...
  14. ncbi Inherited thrombophilia
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Crit Rev Clin Lab Sci 43:249-90. 2006
    ..Finally, we discuss the synergism between genetic and acquired prothrombotic risk factors in particular conditions such as childhood and pregnancy...
  15. ncbi The potential role of recombinant activated FVII in the management of critical hemato-oncological bleeding: a systematic review
    M Franchini
    1Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Bone Marrow Transplant 39:729-35. 2007
    ..Thus, further trials with larger numbers of patients are needed to establish the most appropriate doses and timing of rFVIIa and to assess its efficacy and safety in this setting...
  16. ncbi Antagonists of activated factor X and thrombin: innovative antithrombotic agents
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Curr Vasc Pharmacol 5:121-8. 2007
    ..The aim of this article is to provide an overview on the mechanisms of action, clinical applications, cost-effectiveness and side effects of these emerging anticoagulant strategies...
  17. ncbi Advances in the diagnosis and management of von Willebrand disease
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 11:219-25. 2006
    ..In this review, the present knowledge regarding the diagnosis and the management of VWD is briefly analyzed...
  18. ncbi The effect of iron depletion on chronic hepatitis C virus infection
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Ospedale Policlinico, Piazzale Ludovico Scuro, Verona, 37134, Italy
    Hepatol Int 2:335-40. 2008
    ..Finally, we focus on the effect of iron reduction on the rate of response to interferon antiviral therapy...
  19. ncbi Antithrombotic prophylaxis in patients with von Willebrand disease undergoing major surgery: when is it necessary?
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    J Thromb Thrombolysis 28:215-9. 2009
    ..Thus, in absence of a widely accepted consensus and adequate prospective studies, we advise that the need for thromboprophylaxis in such patients should be evaluated individually, after a careful risk/benefit analysis...
  20. ncbi Clinical, laboratory and therapeutic aspects of platelet-type von Willebrand disease
    M Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Int J Lab Hematol 30:91-4. 2008
    ..In this review, the main clinical, laboratory and therapeutic characteristics of PT-VWD are concisely reported...
  21. ncbi Acquired factor VIII inhibitors in oncohematology: a systematic review
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Ospedale Policlinico, and Dipartimento di Scienze Biomediche e Chirurgiche, Universita di Verona, Piazzale Ludovico Scuro, 37134 Verona, Italy
    Crit Rev Oncol Hematol 66:194-9. 2008
    ..Based on electronic and hand searches of the published literature, this systematic review examines the current knowledge on factor VIII autoantibodies associated with oncohematological disorders...
  22. ncbi Iron and thrombosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Ann Hematol 87:167-73. 2008
    ..The results of the literature on the effect of iron deficiency and overload on vascular health are critically reviewed in this study from a pathogenic and clinical point of view...
  23. ncbi Inherited platelet disorders
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Italy
    Clin Chim Acta 387:1-8. 2008
    ..This review briefly discusses the inherited platelet disorders with respect to molecular defects, diagnostic evaluation and treatment strategies...
  24. ncbi The management of hemophilia in elderly patients
    Massimo Franchini
    Transfusion and Hemophilia Center, City Hospital of Verona, Italy
    Clin Interv Aging 2:361-8. 2007
    ....
  25. ncbi The metabolic syndrome and the risk of arterial and venous thrombosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Thromb Res 122:727-35. 2008
    ..In this review, we will summarize the current knowledge on the relationship between the metabolic syndrome and arterial and venous thrombosis from a pathogenic and clinical point of view...
  26. ncbi Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Thromb J 5:14. 2007
    ..In this review, the most recent advances in our understanding of the mechanisms by which ABO blood group determines plasma VWF levels and their clinical impact will be discussed...
  27. ncbi Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review
    Massimo Franchini
    Immunohematology and Transfusion Center, City Hospital of Verona, Italy
    Blood Coagul Fibrinolysis 18:589-93. 2007
    ..Large randomized trials are needed, however, to confirm the preliminary results and to assess the safety and dosing regimens of this agent in refractory bleeding associated with disseminated intravascular coagulation...
  28. ncbi The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders
    M Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Blood 98:1836-41. 2001
    ..The results confirm the slow progression of HCV infection in HIV-negative hemophiliacs...
  29. ncbi Impact of different inhibitor reactivities with commercial factor VIII concentrates on thrombin generation
    G L Salvagno
    Department of Clinical Chemistry, Verona University Hospital, Verona, Italy
    Haemophilia 13:51-6. 2007
    ..The VWF-containing concentrates Fanhdi and Haemate-P, added to FVIII-deficient plasma with the presence of inhibitor, generate more thrombin than do the purified concentrates Hemofil-M and Kogenate Bayer...
  30. ncbi Recent advances in hereditary hemochromatosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Ann Hematol 84:347-52. 2005
    ..In this review we discuss the genetics, pathophysiology, diagnosis, clinical features, and management of hereditary hemochromatosis...
  31. ncbi Mild hemophilia A
    M Franchini
    Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    J Thromb Haemost 8:421-32. 2010
    ..Many aspects concerning mild HA remain to be clarified, including the molecular basis, the natural history and the optimal diagnostic and therapeutic strategies. Only large prospective studies will shed light on this condition...
  32. ncbi Thrombin generation assay: a useful routine check-up tool in the management of patients with haemophilia?
    G L Salvagno
    Department of Clinical Chemistry, Verona University Hospital, Verona, Italy
    Haemophilia 15:290-6. 2009
    ..We conclude that TG parameters tentatively could be a tool to tailor the global haemostatic capacity in haemophilic patients...
  33. ncbi Effects of secondary prophylaxis started in adolescent and adult haemophiliacs
    A Tagliaferri
    Regional Reference Centre for Inherited Bleeding Disorders, University Hospital, Parma, Italy
    Haemophilia 14:945-51. 2008
    ..With respect to on-demand treatment, higher factor consumption and cost of secondary prophylaxis were balanced by marked clinical benefits and greater well-being in this cohort of adolescent/adult haemophiliacs...
  34. ncbi Dental procedures in adult patients with hereditary bleeding disorders: 10 years experience in three Italian Hemophilia Centers
    M Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Haemophilia 11:504-9. 2005
    ..Thus, our protocol of management of patients with hereditary bleeding tendency undergoing oral treatment or surgery has been shown to be effective in preventing haemorrhagic complications...
  35. ncbi Interferon and ribavirin in HIV-negative haemophiliacs with chronic hepatitis C who were nonresponders to a previous interferon treatment
    M Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Haemophilia 8:794-7. 2002
    ..001). Our study shows that IFN and ribavirin combination therapy is effective in HIV-negative chronically HCV-infected haemophiliacs who do not respond to a previous IFN treatment...
  36. ncbi The natural history of mild haemophilia: a 30-year single centre experience
    A Tagliaferri
    Regional Reference Centre for Inherited Bleeding Disorders, Department of Medicine, University Hospital of Parma, Parma, Italy
    Haemophilia 18:166-74. 2012
    ..The HTCs should improve patients' knowledge and consideration of their disease and encourage them to maintain regular contact with their haemophilia care provider...
  37. ncbi Mortality and causes of death in Italian persons with haemophilia, 1990-2007
    A Tagliaferri
    Regional Reference Centre for Inherited Bleeding Disorders, University Hospital, Parma, Italy
    Haemophilia 16:437-46. 2010
    ..The results of this retrospective study show that in Italian PWH improvements in the quality of treatment and global medical care provided by specialized haemophilia centres resulted in a significantly increased life expectancy...
  38. ncbi [Clinical use of erythropoietin]
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona
    Recenti Prog Med 95:129-36; quiz 185. 2004
    ..In this review, we briefly analyze the main clinical applications of RHuEPO, with particular attention to the potential complications deriving from its use...
  39. ncbi Immune tolerance with rituximab in congenital haemophilia with inhibitors: a systematic literature review based on individual patients' analysis
    M Franchini
    Immunohematology and Transfusion Center, City Hospital of Parma, Parma, Italy
    Haemophilia 14:903-12. 2008
    ..Large prospective randomized studies with an adequate follow-up are needed to confirm these preliminary findings...
  40. ncbi Hereditary iron overload: update on pathophysiology, diagnosis, and treatment
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Italy
    Am J Hematol 81:202-9. 2006
    ..In this review, the genetics, pathophysiology, diagnosis, clinical features, and management of these different types of hereditary hemochromatosis are briefly discussed...
  41. ncbi Surgical prophylaxis in von Willebrand's disease: a difficult balance to manage
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italia
    Blood Transfus 6:s33-8. 2008
    ....
  42. ncbi Influence of warfarin therapy on activated factor VII clotting activity
    Giuseppe Lippi
    Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico-Biomediche, , Verona, Italy
    Blood Coagul Fibrinolysis 17:221-4. 2006
    ..Owing to the good correlation with FVIIa:C, we also hypothesize that the PT and/or FVII:C might be employed for monitoring recombinant FVIIa therapy...
  43. ncbi [Menorrhagia and inherited disorders of coagulation]
    M Franchini
    Centro Emofilia, Azienda Ospedaliera, Servizio di Immunoematologia e Trasfusione, Verona, Italy
    Minerva Ginecol 54:453-60. 2002
    ..Since inherited bleeding disorders are frequently associated with menorrhagia, the conclusion is drawn that an underlying congenital bleeding disorder should be ruled out in any woman with menorrhagia...
  44. ncbi Tyr2105Cys mutation in exon 22 of FVIII gene is a risk factor for the development of inhibitors in patients with mild/moderate haemophilia A
    M Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Haemophilia 12:448-51. 2006
    ..Based on published data, it appears that although this mutation occurs rarely in patients with mild or moderate haemophilia A, it is frequently associated with the development of high-titre inhibitors...
  45. ncbi Influence of temperature and time before centrifugation of specimens for routine coagulation testing
    G L Salvagno
    Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
    Int J Lab Hematol 31:462-7. 2009
    ..In conclusion, a 6-h storage of uncentrifuged specimens at either RT or 4 degrees C may still be suitable to achieve results of routine coagulation testing comprised within the analytical quality specifications for desirable bias...
  46. ncbi Hemophilia and cancer: a new challenge for hemophilia centers
    Massimo Franchini
    Immunohematology and Transfusion Center Department of Pathology and Laboratory Medicine, University Hospital of Parma, Parma, Italy
    Cancer Treat Rev 35:374-7. 2009
    ..These aspects, along with the epidemiology of cancer in hemophiliacs will be discussed in this review...
  47. ncbi Iron overload and hematologic malignancies
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, 37134 Verona, Italy
    Hematol J 5:381-3. 2004
    ..In this review, we briefly report the present knowledge regarding the association between iron overload and hematologic malignancies...
  48. ncbi The bidirectional relationship of cancer and hemostasis and the potential role of anticoagulant therapy in moderating thrombosis and cancer spread
    Massimo Franchini
    Immunohematology and Transfusion Center, Department of Pathology and Laboratory Medicine, University Hospital of Parma, Parma, Italy
    Semin Thromb Hemost 35:644-53. 2009
    ..The main biological and clinical evidence on the relationship between cancer and hemostasis are briefly summarized in this review, as is the potential benefits of anticoagulant therapy in this setting...
  49. ncbi Venous stasis and routine hematologic testing
    G Lippi
    Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
    Clin Lab Haematol 28:332-7. 2006
    ....
  50. ncbi Glycaemic control in athletes
    G Lippi
    Dipartimento di Scienze Morfologico Biomediche, Istituto di Chimica e Microscopia Clinica, Universita di Verona, Verona, Italy
    Int J Sports Med 29:7-10. 2008
    ....
  51. ncbi The use of recombinant activated factor VII in obstetric and gynaecological haemorrhage
    M Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Ospedale Policlinico Azienda Ospedaliera di Verona, Verona, Italy
    BJOG 114:8-15. 2007
    ..However, further evidence is needed to improve the assessment of its optimal dose, effectiveness and safety in such conditions...
  52. ncbi The use of central venous catheters in haemophilia patients
    G Izzi
    Unità Operativa Pediatria e Oncoematologia, Dipartimento Materno Infantile, Parma, Italy
    Haemophilia 16:29-31. 2010
    ..Finally, we describe our personal experience on the use of the external tunnelled catheter Broviac...
  53. ncbi Forum on: the role of recombinant factor VIII in children with severe haemophilia A
    M Franchini
    Immunohaematology and Transfusion Centre, Department of Pathology and Laboratory Medicine, University Hospital of Parma, Parma, Italy
    Haemophilia 15:578-86. 2009
    ..These and other topics concerning rFVIII treatment of haemophilic children were discussed in a meeting held in Rome on 27 February 2008 and are summarized in this report...
  54. ncbi Hemostatic changes in thyroid diseases: haemostasis and thrombosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 11:203-8. 2006
    ....
  55. ncbi Treatment of chronic hepatitis C in haemophilic patients with interferon and ribavirin: a meta-analysis
    Massimo Franchini
    Hemophilia Center, City Hospital, Verona, Italy
    J Antimicrob Chemother 61:1191-200. 2008
    ..In order to analyse the effect of the current combination anti-HCV treatment [i.e. ribavirin plus interferon (IFN)] in this subset of HCV-infected patients, we performed a systematic review with meta-analysis of the available literature...
  56. ncbi Hepatitis C in haemophiliacs
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Ospedale Policlinico, via Delle Menegone 1, 37134 Verona, Italy
    Thromb Haemost 92:1259-68. 2004
    ..Finally, anti-HCV treatment should also be considered for those haemophiliacs co-infected with HIV in whom anti-retroviral treatment has stabilized the HIV infection...
  57. ncbi Onset of severe refractory thrombocytopenia following surgery in a patient with type 2B von Willebrand disease--a case report
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 11:127-9. 2006
    ..As platelet transfusions were ineffective due to alloimunization, effective hemostasis was achieved only with the factor VIII/von Willebrand factor concentrate Haemate P...
  58. ncbi Thrombosis and bleeding: when opposites are not so far apart
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Clin Lab 51:173-82. 2005
    ....
  59. ncbi Thyroid dysfunction and hemostasis: an issue still unresolved
    Massimo Franchini
    Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero Universitaria di Parma, Italy
    Semin Thromb Hemost 35:288-94. 2009
    ..Further trials on larger series of patients are needed to confirm these preliminary findings and to elucidate the pathogenic mechanisms regulating the complex interaction between thyroid disorders and hemostasis...
  60. ncbi Recombinant factor VIIa: a review on its clinical use
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Italy
    Int J Hematol 83:126-38. 2006
    ....
  61. ncbi Efficacy and safety of phlebotomy to reduce transfusional iron overload in adult, long-term survivors of acute leukemia
    Massimo Franchini
    Immunhematology and Transfusion Service, Hospital of Verona, Verona, Italy
    Transfusion 44:833-7. 2004
    ..Transfusional iron overload is a frequent finding in long-term survivors of acute leukemia (AL). Only a few studies have reported the results of iron depletion therapy in this category of patients...
  62. ncbi The use of recombinant activated factor VII in congenital and acquired von Willebrand disease
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Blood Coagul Fibrinolysis 17:615-9. 2006
    ..Further studies are needed, however, to assess its safety and to optimize the dosages and regimens of therapy in such patients...
  63. ncbi High prevalence of inherited prothrombotic risk factors in 134 consecutive patients with von Willebrand disease
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Am J Hematol 81:465-7. 2006
    ..Three carriers of multiple prothrombotic gene mutations experienced a thrombotic event. Our study suggests that the recent evidence of an association between inherited thrombotic and hemorrhagic disorders also holds true in VWD patients...
  64. ncbi Biochemistry, physiology, and complications of blood doping: facts and speculation
    Giuseppe Lippi
    Dipartimento di Scienze Morfologico-Biomediche, Istituto di Chimica e Microscopia Clinica, , Verona, Italy
    Crit Rev Clin Lab Sci 43:349-91. 2006
    ..The aim of this review is to discuss the biochemistry, physiology, and complications of blood doping and to provide an update on current antidoping policies...
  65. ncbi Hemostasis and aging
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Ospedale Policlinico, Piazzale Ludovico Scuro, Azienda Ospedaliera di Verona, 37134 Verona, Italy
    Crit Rev Oncol Hematol 60:144-51. 2006
    ..The complex inter-relationships between inherited and acquired factors influencing the hemostatic system during aging are discussed in this review...
  66. ncbi Thrombotic complications in patients with hereditary bleeding disorders
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedale di Verona, Verona, Italy
    Thromb Haemost 92:298-304. 2004
    ....
  67. ncbi The hemostatic balance revisited through the lessons of mankind evolution
    Massimo Franchini
    Transfusion and Hemophilia Center, City Hospital of Verona, Piazzale Ludovico Scuro, 37134 Verona, Italy
    Intern Emerg Med 3:3-8. 2008
    ..The effect of inherited bleeding disorders on the development of thrombotic or atherosclerotic processes is also discussed...
  68. ncbi Immunohematological aspects of bone marrow transplantation
    G Gandini
    Servizio di Immunoematologia e Transfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 7:89-93. 2002
    ....
  69. ncbi Non-ABO red blood cell alloantibodies following allogeneic hematopoietic stem cell transplantation
    M Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Bone Marrow Transplant 33:1169-72. 2004
    ....
  70. ncbi [Preoperative laboratory testing]
    G Lippi
    Unità di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
    Minerva Med 96:397-407. 2005
    ..This article aims to provide a comprehensive review of the current literature on this topic, attempting to suggest a suitable approach to the puzzling issue of preoperative laboratory testing...
  71. ncbi Evaluating kidney damage from vesico-ureteral reflux in children
    M Zaffanello
    Department of Mother Child and Biology Genetics, University of Verona, Italy
    Saudi J Kidney Dis Transpl 20:57-68. 2009
    ..Progression of kidney damage may depend on the severity of VUR and untreated urinary tract infections. Prevention of congenital kidney damage from severe VUR is possible when there is early intervention, even during fetal growth...
  72. ncbi Increased D-dimer value and occult cancer in the absence of detectable thrombosis
    G Lippi
    Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Italy
    Haematologica 92:e53-5. 2007
    ..This case allow us to hypothesize that screening for occult malignancy in the presence of apparently inexplicable elevated D-dimer values may be taken into consideration...
  73. ncbi Reduced von Willebrand factor-cleaving protease levels in secondary thrombotic microangiopathies and other diseases
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Semin Thromb Hemost 33:787-97. 2007
    ..This latter issue will be critically addressed in this review article. In addition, the published literature evaluating plasma ADAMTS-13 levels in other pathologic conditions different from TMA will also be discussed...
  74. ncbi Efficacy of Helicobacter pylori eradication in raising platelet count in adult patients with idiopathic thrombocytopenic purpura
    Dino Veneri
    Dipartimento di Medicina Clinica e Sperimentale, Divisione di Ematologia, Universita di Verona, Italy
    Haematologica 87:1177-9. 2002
    ..In addition, a significant increase of platelet count following HP eradication has been reported in a proportion of ITP patients. We describe here our experience on the efficacy of anti-HP treatment in ITP patients...
  75. ncbi The paradoxical relationship between serum uric acid and cardiovascular disease
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Universita di Verona, Italy
    Clin Chim Acta 392:1-7. 2008
    ..The aim of this article is to review uric acid metabolism and physiology, highlighting its association with cardiovascular disease...
  76. ncbi Air pollution and coagulation testing: a new source of biological variability?
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Ospedale Policlinico G B Rossi, Piazzale Scuro, 10, 37134 Verona, Italy
    Thromb Res 123:50-4. 2008
    ....
  77. ncbi A severe adverse event in an elderly patient undergoing preoperative autologous blood donation
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Haematologica 87:ECR24. 2002
  78. ncbi The use of recombinant factor VIIa in liver diseases
    Massimo Franchini
    Immuno hematology and Transfusion Center, City Hospital of Verona, Italy
    Blood Coagul Fibrinolysis 19:341-8. 2008
    ..In conclusion, further large randomized, controlled clinical trials are needed to better define the role of recombinant activated factor VII in the treatment of bleeding complications of liver disorders...
  79. ncbi NASH predicts plasma inflammatory biomarkers independently of visceral fat in men
    Giovanni Targher
    Department of Internal Medicine, Sacro Cuore Hospital, Negrar VR, Italy
    Obesity (Silver Spring) 16:1394-9. 2008
    ..In conclusion, our results suggest that NASH can predict a more atherogenic risk profile in a manner that is partly independent from the contribution of visceral adiposity in adult men...
  80. ncbi Moderate red wine consumption and cardiovascular disease risk: beyond the "French paradox"
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Semin Thromb Hemost 36:59-70. 2010
    ....
  81. ncbi Influence of a light meal on routine haematological tests
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche University of Verona, Ospedale Policlinico G B Rossi, Verona, Italy
    Blood Transfus 8:94-9. 2010
    ..However, no clear indications about fasting requirements exist for routine haematological tests, nor has the influence of meals been assessed...
  82. ncbi Analysis of HFE and TFR2 gene mutations in patients with acute leukemia
    Dino Veneri
    Dipartimento di Medicina Sperimentale e Clinica, Divisione di Ematologia, Universita di Verona, 37134 Verona, Italy
    Leuk Res 29:661-4. 2005
    ..Our study does not support the evidence of an association between hemochromatosis gene mutations and iron overload in AL patients...
  83. ncbi Thrombotic microangiopathies: an update
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 11:139-46. 2006
    ..In this review, we focus on the epidemiologic and diagnostic criteria as well as on the most recent insights into the pathophysiology and treatment of these two conditions...
  84. ncbi Therapy for children with henoch-schonlein purpura nephritis: a systematic review
    Marco Zaffanello
    Department of Paediatrics, University of Verona, Italy
    ScientificWorldJournal 7:20-30. 2007
    ..However, no convincing studies have been made to date concerning either intravenous immunoglobulin, factor XIII administration, antioxidant vitamin E, and fish oil to treat HSP nephritis...
  85. ncbi [Helicobacter pylori infection and idiopathic thrombocytopenic purpura]
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona
    Recenti Prog Med 96:151-4. 2005
    ..However, since the studies so far published are few, sometimes controversial and involve small series of patients, further studies on larger numbers of patients with longer followup are needed to confirm these preliminary findings...
  86. ncbi Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
    Bone 39:678-83. 2006
    ..We discuss here the potential use of MSCs in degenerative or inflammatory diseases involving bone, cartilage, tendon and muscle tissues, on the basis of the experimental evidence...
  87. ncbi Helicobacter pylori infection and immune thrombocytopenic purpura: an update
    Massimo Franchini
    Transfusion Service, Azienda Ospedaliera di Verona, Italy
    Helicobacter 9:342-6. 2004
    ....
  88. ncbi [Transfusional therapy of hemodialyzed patient with anti-Cartwright antibodies: case report and review of the literature]
    M Franchini
    Servizio di Immunoematologia e Trasfusione, Ospedale Civile Maggiore, Verona
    G Ital Nefrol 21:387-90. 2004
    ..No adverse reactions nor hemolysis were detected. CONCLUSIONS: We concluded that dialysis patients with anti-Yta antibodies could be safely transfused with blood from Cartwright positive donors...
  89. ncbi Efficacy of desmopressin as surgical prophylaxis in patients with acquired von Willebrand disease undergoing thyroid surgery
    M Franchini
    Servizio di Immunoematologia e Trasfusione, Istituto di Chimica e Microscopia Clinica and Dipartimento di Chirurgia, Verona, Italy
    Haemophilia 8:142-4. 2002
    ..This study highlights the need for coagulation studies in patients with thyroid diseases undergoing thyroid surgery. Subcutaneous desmopressin may be used in these patients in order to prevent a surgically related bleeding risk...
  90. ncbi Unrelated allogeneic bone marrow donation: short- and long-term follow-up of 103 consecutive volunteer donors
    A Gandini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Bone Marrow Transplant 28:369-74. 2001
    ..1 months). All donors signed a written informed consent for a further bone marrow collection, if needed. Our findings confirm the short- and long-term safety of allogeneic bone marrow collection in volunteer donors...
  91. ncbi Preoperative autologous blood donation in primary total knee arthroplasty: a single-centre experience on 214 consecutive patients
    M Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Vox Sang 90:191-4. 2006
    ....
  92. ncbi Switch off the light on cycling, switch off the light on doping
    G Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, , Ospedale Policlinico GB Rossi, Piazzale Scuro, 10, 37134 Verona, Italy
    Br J Sports Med 42:162. 2008
  93. ncbi Non-steroidal anti-inflammatory drugs in athletes
    G Lippi
    Department of Morphological-Biomedical Science, Institute of Chemical and Clinical Microscopy, University of Verona, Verona, Italy
    Br J Sports Med 40:661-2; discussion 662-3. 2006
  94. ncbi Biochemistry and physiology of anabolic androgenic steroids doping
    G Lippi
    UO Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Mini Rev Med Chem 11:362-73. 2011
    ..The aim of this article is to review the biochemistry, physiology and the ergogenic effects of AASs...
  95. ncbi Genetic risk for recurrent urinary tract infections in humans: a systematic review
    M Zaffanello
    Department of Mother Child and Biology Genetics, Section of Pediatrics, University of Verona, Piazzale L Scuro 10, 37134 Verona, Italy
    J Biomed Biotechnol 2010:321082. 2010
    ..In particular, the HSPA1B, CXCR1 & 2, TLR2, TLR4, TGF-beta1 genes seem to be associated with an alteration of the host response to UTIs at various levels...
  96. ncbi Total and free PSA serum concentrations are not influenced by extensive physical exercise and bicycle riding
    G Lippi
    Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico-Biomediche, , Verona, Italy
    Int J Sports Med 26:79-81. 2005
    ..We hypothesize that neither a heavy and regular physical exercise nor the extensive and prolonged mechanical involvement of the prostate region by the bicycle riding have significant influence on release of both PSA and fPSA...
  97. ncbi Hemostasis and thyroid diseases revisited
    M Franchini
    Immunohematology and Transfusion Service, Hemophilia Center, Hospital of Verona, Verona, Italy
    J Endocrinol Invest 27:886-92. 2004
    ....
  98. ncbi Thrombotic thrombocytopenic purpura: proposal of a new pathogenic mechanism involving Helicobacter pylori infection
    M Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Ospedale Policlinico, Piazzale Ludovico Scuro, 37134 Verona, Italy
    Med Hypotheses 65:1128-31. 2005
    ....
  99. ncbi Cobalt chloride administration in athletes: a new perspective in blood doping?
    G Lippi
    Ist Chimica e Microscopia Clinica, Universita di Verona, Verona, Italy
    Br J Sports Med 39:872-3. 2005
    ..Although there is as yet no direct or anecdotal evidence of cobalt chloride administration to athletes, its use should be warned against as being not only unfair but potentially dangerous...
  100. ncbi Short-term effects of air pollution on cardiovascular diseases: outcomes and mechanisms
    M Franchini
    Transfusion and Hemophilia Center, City Hospital of Verona, Verona, Italy
    J Thromb Haemost 5:2169-74. 2007
    ..The evidence from the literature on the short-term cardiovascular effects of air pollutants is discussed from clinical and mechanistic points of view...
  101. ncbi Are thrombotic complications in patients with von Willebrand's disease expression of a multifactorial disease?
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona
    Haematologica 90:ECR34. 2005