M Franchini

Summary

Affiliation: University of Verona
Country: Italy

Publications

  1. ncbi Recent advances in hereditary hemochromatosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Ann Hematol 84:347-52. 2005
  2. ncbi [Inherited thrombophilia]
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona
    Recenti Prog Med 96:95-101. 2005
  3. ncbi Von Willebrand factor and thrombosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Ospedale Policlinico, Azienda Ospedaliera di Verona, Piazzale L Scuro, 10, 37134, Verona, Italy
    Ann Hematol 85:415-23. 2006
  4. ncbi Helicobacter pylori infection and immune thrombocytopenic purpura: an update
    Massimo Franchini
    Transfusion Service, Azienda Ospedaliera di Verona, Italy
    Helicobacter 9:342-6. 2004
  5. ncbi Iron-chelation therapy: an update
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Hematol J 5:287-92. 2004
  6. ncbi Thrombotic complications in von Willebrand disease
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 11:49-52. 2006
  7. ncbi Helicobacter pylori-associated immune thrombocytopenia
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Platelets 17:71-7. 2006
  8. ncbi Pathophysiology, diagnosis and treatment of disseminated intravascular coagulation: an update
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Clin Lab 51:633-9. 2005
  9. ncbi Acquired coagulation inhibitor-associated bleeding disorders: an update
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 10:443-9. 2005
  10. ncbi Efficacy of Haemate-P as prophylaxis of recurrent bleeding in a patient with type 2B von Willebrand's disease
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Blood Coagul Fibrinolysis 16:571-2. 2005

Detail Information

Publications121 found, 100 shown here

  1. ncbi Recent advances in hereditary hemochromatosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Ann Hematol 84:347-52. 2005
    ..In this review we discuss the genetics, pathophysiology, diagnosis, clinical features, and management of hereditary hemochromatosis...
  2. ncbi [Inherited thrombophilia]
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona
    Recenti Prog Med 96:95-101. 2005
    ..Finally, we discuss the synergism between genetic and acquired prothrombotic risk factors in some conditions such as pregnancy and cardiovascular diseases...
  3. ncbi Von Willebrand factor and thrombosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Ospedale Policlinico, Azienda Ospedaliera di Verona, Piazzale L Scuro, 10, 37134, Verona, Italy
    Ann Hematol 85:415-23. 2006
    ..After a description of the structure and physiology of VWF, all these aspects are discussed in the present review...
  4. ncbi Helicobacter pylori infection and immune thrombocytopenic purpura: an update
    Massimo Franchini
    Transfusion Service, Azienda Ospedaliera di Verona, Italy
    Helicobacter 9:342-6. 2004
    ....
  5. ncbi Iron-chelation therapy: an update
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Hematol J 5:287-92. 2004
    ..We also present a meta-analysis of the largest trials on the oral iron chelator deferiprone and the results of combined therapy (deferiprone and desferrioxamine)...
  6. ncbi Thrombotic complications in von Willebrand disease
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 11:49-52. 2006
    ....
  7. ncbi Helicobacter pylori-associated immune thrombocytopenia
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Platelets 17:71-7. 2006
    ....
  8. ncbi Pathophysiology, diagnosis and treatment of disseminated intravascular coagulation: an update
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Clin Lab 51:633-9. 2005
    ..Particular attention is given to novel therapeutic strategies, which reflect the important progresses made in the understanding of the pathogenesis of this disorder in the last few years...
  9. ncbi Acquired coagulation inhibitor-associated bleeding disorders: an update
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 10:443-9. 2005
    ..e. the autoantibodies occurring in individuals without a pre-existent coagulation defect, reporting the most recent advances in the pathophysiology, diagnosis and treatment of these rare acquired bleeding disorders...
  10. ncbi Efficacy of Haemate-P as prophylaxis of recurrent bleeding in a patient with type 2B von Willebrand's disease
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Blood Coagul Fibrinolysis 16:571-2. 2005
    ..Prophylaxis with Haemate-P was shown to be safe and effective in this patient, thus enabling completion of radiochemotherapy...
  11. ncbi Analysis of hemochromatosis gene mutations in 52 consecutive patients with polycythemia vera
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 9:413-4. 2004
    ..Our results support the evidence that there is no association between these two conditions...
  12. ncbi Acquired hemophilia A: a concise review
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Italy
    Am J Hematol 80:55-63. 2005
    ..We also describe the main characteristics of this disorder according to its association with different conditions and the most important advances in the treatment of bleeding episodes and the eradication of the autoantibody...
  13. ncbi [Helicobacter pylori infection and idiopathic thrombocytopenic purpura]
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona
    Recenti Prog Med 96:151-4. 2005
    ..However, since the studies so far published are few, sometimes controversial and involve small series of patients, further studies on larger numbers of patients with longer followup are needed to confirm these preliminary findings...
  14. ncbi Recent acquisitions in the management of iron overload
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Piazzale L Scuro, 10, 37134, Verona, Italy
    Ann Hematol 84:640-5. 2005
    ..In this review, we describe the most important advances in iron-chelation therapy...
  15. ncbi Thrombotic thrombocytopenic purpura: proposal of a new pathogenic mechanism involving Helicobacter pylori infection
    M Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Ospedale Policlinico, Piazzale Ludovico Scuro, 37134 Verona, Italy
    Med Hypotheses 65:1128-31. 2005
    ....
  16. ncbi Inherited thrombophilia: an update
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Clin Lab 51:357-65. 2005
    ..Finally, we discuss the synergism between genetic and acquired prothrombotic risk factors in some conditions such as pregnancy and cardiovascular diseases...
  17. ncbi Update on the treatment of disseminated intravascular coagulation
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Ospedale Policlinico, Piazzale Ludovico Scuro, 37134 Verona, Italy
    Hematology 9:81-5. 2004
    ..Moreover, particular attention is made to novel therapeutic strategies, who reflect the important progresses in the understanding of the pathogenesis of this syndrome in the last few years...
  18. ncbi Advances in the pathogenesis, diagnosis and treatment of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Ospedale Policlinico, Piazzale L Scuro Azienda Ospedaliera di Verona, Italy
    Thromb Res 118:177-84. 2006
    ..In this review, we briefly focus on the most important advances in the pathophysiology, diagnosis and treatment of these two thrombotic microangiopathies...
  19. ncbi A severe adverse event in an elderly patient undergoing preoperative autologous blood donation
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Haematologica 87:ECR24. 2002
  20. ncbi Interferon and ribavirin in HIV-negative haemophiliacs with chronic hepatitis C who were nonresponders to a previous interferon treatment
    M Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Haemophilia 8:794-7. 2002
    ..001). Our study shows that IFN and ribavirin combination therapy is effective in HIV-negative chronically HCV-infected haemophiliacs who do not respond to a previous IFN treatment...
  21. ncbi Thrombotic microangiopathies: an update
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 11:139-46. 2006
    ..In this review, we focus on the epidemiologic and diagnostic criteria as well as on the most recent insights into the pathophysiology and treatment of these two conditions...
  22. ncbi Platelet count increase following phlebotomy in iron overloaded patients with liver cirrhosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Italy
    Hematology 8:259-62. 2003
    ..Our results show that phlebotomy is effective not only in lowering iron overload, but also in improving liver function and thrombocytopenia in patients with liver cirrhosis...
  23. ncbi Efficacy and safety of factor VIII/von Willebrand's factor concentrate (Haemate-P) in preventing bleeding during surgery or invasive procedures in patients with von Willebrand disease
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Haematologica 88:1279-83. 2003
    ..To evaluate the efficacy and safety of the factor VIII/von Willebrand factor concentrate Haemate-P as replacement therapy in patients with von Willebrand's disease (VWD) undergoing surgical or invasive procedures...
  24. ncbi Acquired hemophilia A
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 11:119-25. 2006
    ..Moreover, new therapeutic strategies (anti-CD20 monoclonal antibody and immune tolerance protocols) are very promising and may further improve the prognosis of acquired hemophilia A...
  25. ncbi The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders
    M Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Blood 98:1836-41. 2001
    ..The results confirm the slow progression of HCV infection in HIV-negative hemophiliacs...
  26. ncbi Impact of different inhibitor reactivities with commercial factor VIII concentrates on thrombin generation
    G L Salvagno
    Department of Clinical Chemistry, Verona University Hospital, Verona, Italy
    Haemophilia 13:51-6. 2007
    ..The VWF-containing concentrates Fanhdi and Haemate-P, added to FVIII-deficient plasma with the presence of inhibitor, generate more thrombin than do the purified concentrates Hemofil-M and Kogenate Bayer...
  27. doi Thrombin generation assay: a useful routine check-up tool in the management of patients with haemophilia?
    G L Salvagno
    Department of Clinical Chemistry, Verona University Hospital, Verona, Italy
    Haemophilia 15:290-6. 2009
    ..We conclude that TG parameters tentatively could be a tool to tailor the global haemostatic capacity in haemophilic patients...
  28. ncbi Dental procedures in adult patients with hereditary bleeding disorders: 10 years experience in three Italian Hemophilia Centers
    M Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Haemophilia 11:504-9. 2005
    ..Thus, our protocol of management of patients with hereditary bleeding tendency undergoing oral treatment or surgery has been shown to be effective in preventing haemorrhagic complications...
  29. ncbi [Clinical use of erythropoietin]
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona
    Recenti Prog Med 95:129-36; quiz 185. 2004
    ..In this review, we briefly analyze the main clinical applications of RHuEPO, with particular attention to the potential complications deriving from its use...
  30. ncbi [Menorrhagia and inherited disorders of coagulation]
    M Franchini
    Centro Emofilia, Azienda Ospedaliera, Servizio di Immunoematologia e Trasfusione, Verona, Italy
    Minerva Ginecol 54:453-60. 2002
    ..Since inherited bleeding disorders are frequently associated with menorrhagia, the conclusion is drawn that an underlying congenital bleeding disorder should be ruled out in any woman with menorrhagia...
  31. pmc Surgical prophylaxis in von Willebrand's disease: a difficult balance to manage
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italia
    Blood Transfus 6:s33-8. 2008
    ....
  32. ncbi Influence of warfarin therapy on activated factor VII clotting activity
    Giuseppe Lippi
    Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
    Blood Coagul Fibrinolysis 17:221-4. 2006
    ..Owing to the good correlation with FVIIa:C, we also hypothesize that the PT and/or FVII:C might be employed for monitoring recombinant FVIIa therapy...
  33. ncbi Hereditary iron overload: update on pathophysiology, diagnosis, and treatment
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Italy
    Am J Hematol 81:202-9. 2006
    ..In this review, the genetics, pathophysiology, diagnosis, clinical features, and management of these different types of hereditary hemochromatosis are briefly discussed...
  34. doi Influence of temperature and time before centrifugation of specimens for routine coagulation testing
    G L Salvagno
    Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
    Int J Lab Hematol 31:462-7. 2009
    ..In conclusion, a 6-h storage of uncentrifuged specimens at either RT or 4 degrees C may still be suitable to achieve results of routine coagulation testing comprised within the analytical quality specifications for desirable bias...
  35. ncbi The potential role of recombinant activated FVII in the management of critical hemato-oncological bleeding: a systematic review
    M Franchini
    1Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Bone Marrow Transplant 39:729-35. 2007
    ..Thus, further trials with larger numbers of patients are needed to establish the most appropriate doses and timing of rFVIIa and to assess its efficacy and safety in this setting...
  36. ncbi Tyr2105Cys mutation in exon 22 of FVIII gene is a risk factor for the development of inhibitors in patients with mild/moderate haemophilia A
    M Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Haemophilia 12:448-51. 2006
    ..Based on published data, it appears that although this mutation occurs rarely in patients with mild or moderate haemophilia A, it is frequently associated with the development of high-titre inhibitors...
  37. ncbi Venous stasis and routine hematologic testing
    G Lippi
    Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
    Clin Lab Haematol 28:332-7. 2006
    ....
  38. ncbi Iron overload and hematologic malignancies
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, 37134 Verona, Italy
    Hematol J 5:381-3. 2004
    ..In this review, we briefly report the present knowledge regarding the association between iron overload and hematologic malignancies...
  39. ncbi Glycaemic control in athletes
    G Lippi
    Dipartimento di Scienze Morfologico Biomediche, Istituto di Chimica e Microscopia Clinica, Universita di Verona, Verona, Italy
    Int J Sports Med 29:7-10. 2008
    ....
  40. ncbi Preoperative autologous blood donation in primary total knee arthroplasty: a single-centre experience on 214 consecutive patients
    M Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Vox Sang 90:191-4. 2006
    ....
  41. doi Treatment of chronic hepatitis C in haemophilic patients with interferon and ribavirin: a meta-analysis
    Massimo Franchini
    Hemophilia Center, City Hospital, Verona, Italy
    J Antimicrob Chemother 61:1191-200. 2008
    ..In order to analyse the effect of the current combination anti-HCV treatment [i.e. ribavirin plus interferon (IFN)] in this subset of HCV-infected patients, we performed a systematic review with meta-analysis of the available literature...
  42. ncbi Efficacy and safety of phlebotomy to reduce transfusional iron overload in adult, long-term survivors of acute leukemia
    Massimo Franchini
    Immunhematology and Transfusion Service, Hospital of Verona, Verona, Italy
    Transfusion 44:833-7. 2004
    ..Transfusional iron overload is a frequent finding in long-term survivors of acute leukemia (AL). Only a few studies have reported the results of iron depletion therapy in this category of patients...
  43. ncbi High prevalence of inherited prothrombotic risk factors in 134 consecutive patients with von Willebrand disease
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Am J Hematol 81:465-7. 2006
    ..Three carriers of multiple prothrombotic gene mutations experienced a thrombotic event. Our study suggests that the recent evidence of an association between inherited thrombotic and hemorrhagic disorders also holds true in VWD patients...
  44. ncbi Onset of severe refractory thrombocytopenia following surgery in a patient with type 2B von Willebrand disease--a case report
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 11:127-9. 2006
    ..As platelet transfusions were ineffective due to alloimunization, effective hemostasis was achieved only with the factor VIII/von Willebrand factor concentrate Haemate P...
  45. ncbi Biochemistry, physiology, and complications of blood doping: facts and speculation
    Giuseppe Lippi
    Dipartimento di Scienze Morfologico Biomediche, Istituto di Chimica e Microscopia Clinica, Universita degli Studi di Verona, Verona, Italy
    Crit Rev Clin Lab Sci 43:349-91. 2006
    ..The aim of this review is to discuss the biochemistry, physiology, and complications of blood doping and to provide an update on current antidoping policies...
  46. ncbi Hemostasis and aging
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Ospedale Policlinico, Piazzale Ludovico Scuro, Azienda Ospedaliera di Verona, 37134 Verona, Italy
    Crit Rev Oncol Hematol 60:144-51. 2006
    ..The complex inter-relationships between inherited and acquired factors influencing the hemostatic system during aging are discussed in this review...
  47. ncbi Hemostatic changes in thyroid diseases: haemostasis and thrombosis
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 11:203-8. 2006
    ....
  48. ncbi The use of recombinant activated factor VII in congenital and acquired von Willebrand disease
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Blood Coagul Fibrinolysis 17:615-9. 2006
    ..Further studies are needed, however, to assess its safety and to optimize the dosages and regimens of therapy in such patients...
  49. ncbi Thrombotic complications in patients with hereditary bleeding disorders
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedale di Verona, Verona, Italy
    Thromb Haemost 92:298-304. 2004
    ....
  50. doi The hemostatic balance revisited through the lessons of mankind evolution
    Massimo Franchini
    Transfusion and Hemophilia Center, City Hospital of Verona, Piazzale Ludovico Scuro, 37134 Verona, Italy
    Intern Emerg Med 3:3-8. 2008
    ..The effect of inherited bleeding disorders on the development of thrombotic or atherosclerotic processes is also discussed...
  51. ncbi Thrombosis and bleeding: when opposites are not so far apart
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Clin Lab 51:173-82. 2005
    ....
  52. ncbi Hepatitis C in haemophiliacs
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Ospedale Policlinico, via Delle Menegone 1, 37134 Verona, Italy
    Thromb Haemost 92:1259-68. 2004
    ..Finally, anti-HCV treatment should also be considered for those haemophiliacs co-infected with HIV in whom anti-retroviral treatment has stabilized the HIV infection...
  53. ncbi Recombinant factor VIIa: a review on its clinical use
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Italy
    Int J Hematol 83:126-38. 2006
    ....
  54. doi Clinical, laboratory and therapeutic aspects of platelet-type von Willebrand disease
    M Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Int J Lab Hematol 30:91-4. 2008
    ..In this review, the main clinical, laboratory and therapeutic characteristics of PT-VWD are concisely reported...
  55. ncbi Non-ABO red blood cell alloantibodies following allogeneic hematopoietic stem cell transplantation
    M Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Bone Marrow Transplant 33:1169-72. 2004
    ....
  56. ncbi [Transfusional therapy of hemodialyzed patient with anti-Cartwright antibodies: case report and review of the literature]
    M Franchini
    Servizio di Immunoematologia e Trasfusione, Ospedale Civile Maggiore, Verona
    G Ital Nefrol 21:387-90. 2004
    ..Report about clinical significance of Yta red cell alloantibodies in hemodialysis (HD) patients are scarce...
  57. ncbi Evaluating kidney damage from vesico-ureteral reflux in children
    M Zaffanello
    Department of Mother Child and Biology Genetics, University of Verona, Italy
    Saudi J Kidney Dis Transpl 20:57-68. 2009
    ..Progression of kidney damage may depend on the severity of VUR and untreated urinary tract infections. Prevention of congenital kidney damage from severe VUR is possible when there is early intervention, even during fetal growth...
  58. ncbi Increased D-dimer value and occult cancer in the absence of detectable thrombosis
    G Lippi
    Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Italy
    Haematologica 92:e53-5. 2007
    ..This case allow us to hypothesize that screening for occult malignancy in the presence of apparently inexplicable elevated D-dimer values may be taken into consideration...
  59. ncbi Therapy for children with henoch-schonlein purpura nephritis: a systematic review
    Marco Zaffanello
    Department of Paediatrics, University of Verona, Italy
    ScientificWorldJournal 7:20-30. 2007
    ..However, no convincing studies have been made to date concerning either intravenous immunoglobulin, factor XIII administration, antioxidant vitamin E, and fish oil to treat HSP nephritis...
  60. ncbi Rituximab for the treatment of childhood chronic idiopathic thrombocytopenic purpura and hemophilia with inhibitors
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Pediatr Blood Cancer 49:6-10. 2007
    ..Therefore, large, prospective, and randomized trials are needed to confirm the positive, preliminary results...
  61. ncbi Low-dose epirubicin in combination with cyclophosphamide, vinblastine and prednisone (mini-CEOP) for the treatment of aggressive non-Hodgkin's lymphoma in elderly patients
    Dino Veneri
    Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Universita di Verona, Italy
    Haematologica 87:ELT43. 2002
  62. doi Reduced von Willebrand factor-cleaving protease levels in secondary thrombotic microangiopathies and other diseases
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Semin Thromb Hemost 33:787-97. 2007
    ..This latter issue will be critically addressed in this review article. In addition, the published literature evaluating plasma ADAMTS-13 levels in other pathologic conditions different from TMA will also be discussed...
  63. ncbi Drug-induced anti-factor VIII antibodies: a systematic review
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Med Sci Monit 13:RA55-61. 2007
    ..3%). However, further studies are needed to better elucidate the epidemiology, natural history, clinical relevance, and optimal treatment of drug-associated factor VIII autoantibodies...
  64. doi NASH predicts plasma inflammatory biomarkers independently of visceral fat in men
    Giovanni Targher
    Department of Internal Medicine, Sacro Cuore Hospital, Negrar VR, Italy
    Obesity (Silver Spring) 16:1394-9. 2008
    ..In conclusion, our results suggest that NASH can predict a more atherogenic risk profile in a manner that is partly independent from the contribution of visceral adiposity in adult men...
  65. ncbi Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review
    Massimo Franchini
    Immunohematology and Transfusion Center, City Hospital of Verona, Italy
    Blood Coagul Fibrinolysis 18:589-93. 2007
    ..Large randomized trials are needed, however, to confirm the preliminary results and to assess the safety and dosing regimens of this agent in refractory bleeding associated with disseminated intravascular coagulation...
  66. ncbi Efficacy of Helicobacter pylori eradication in raising platelet count in adult patients with idiopathic thrombocytopenic purpura
    Dino Veneri
    Dipartimento di Medicina Clinica e Sperimentale, Divisione di Ematologia, Universita di Verona, Italy
    Haematologica 87:1177-9. 2002
    ..In addition, a significant increase of platelet count following HP eradication has been reported in a proportion of ITP patients. We describe here our experience on the efficacy of anti-HP treatment in ITP patients...
  67. doi The paradoxical relationship between serum uric acid and cardiovascular disease
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Universita di Verona, Italy
    Clin Chim Acta 392:1-7. 2008
    ..The aim of this article is to review uric acid metabolism and physiology, highlighting its association with cardiovascular disease...
  68. ncbi The use of desmopressin as a hemostatic agent: a concise review
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Am J Hematol 82:731-5. 2007
    ..This review briefly summarizes the current clinical indications on the use of desmopressin as a hemostatic agent...
  69. doi Air pollution and coagulation testing: a new source of biological variability?
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Ospedale Policlinico G B Rossi, Piazzale Scuro, 10, 37134 Verona, Italy
    Thromb Res 123:50-4. 2008
    ....
  70. doi Are children with congenital solitary kidney at risk for lifelong complications? A lack of prediction demands caution
    Marco Zaffanello
    Department of Mother Child and Biology Genetics, University of Verona, Verona, Italy
    Int Urol Nephrol 41:127-35. 2009
    ..Since the risk of renal failure in children with CSFK depends on several variables, it is always advisable to have a precise clinical description at diagnosis. This condition often requires long-term follow-up into adulthood...
  71. doi Moderate red wine consumption and cardiovascular disease risk: beyond the "French paradox"
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Semin Thromb Hemost 36:59-70. 2010
    ....
  72. pmc Influence of a light meal on routine haematological tests
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche University of Verona, Ospedale Policlinico G B Rossi, Verona, Italy
    Blood Transfus 8:94-9. 2010
    ..However, no clear indications about fasting requirements exist for routine haematological tests, nor has the influence of meals been assessed...
  73. ncbi Evidence-based treatment limitations prevent any therapeutic recommendation for acute poststreptococcal glomerulonephritis in children
    Marco Zaffanello
    Department of Mother Child and Biology Genetics, University of Verona, 37134 Verona, Italy
    Med Sci Monit 16:RA79-84. 2010
    ..The studies were of small number and with limitations that seriously weaken the results...
  74. ncbi Analysis of HFE and TFR2 gene mutations in patients with acute leukemia
    Dino Veneri
    Dipartimento di Medicina Sperimentale e Clinica, Divisione di Ematologia, Universita di Verona, 37134 Verona, Italy
    Leuk Res 29:661-4. 2005
    ..Our study does not support the evidence of an association between hemochromatosis gene mutations and iron overload in AL patients...
  75. doi Unsuspected triggers of venous thromboembolism--trivial or not so trivial?
    Giuseppe Lippi
    U O Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospadaliero Universitaria di Parma, Parma, Italy
    Semin Thromb Hemost 35:597-604. 2009
    ....
  76. ncbi Haemostasis and pregnancy
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Ospedale Policlinico, Piazzale L Scuro, 10, 37134 Verona, Italy
    Thromb Haemost 95:401-13. 2006
    ..Based on an analysis of the literature data, this review presents an overview of the main thrombotic and haemorrhagic disorders complicating pregnancy...
  77. ncbi Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair
    Mauro Krampera
    Department of Clinical and Experimental Medicine, Section of Haematology, University of Verona, Italy
    Bone 39:678-83. 2006
    ..We discuss here the potential use of MSCs in degenerative or inflammatory diseases involving bone, cartilage, tendon and muscle tissues, on the basis of the experimental evidence...
  78. ncbi Urological complications and copper replacement therapy in childhood Menkes syndrome
    Marco Zaffanello
    Department of Mother and Child, Biology Genetics, Section of Paediatrics, University of Verona, Verona, Italy
    Acta Paediatr 95:785-90. 2006
    ..Urological complications are frequent in Menkes syndrome, a very rare X-linked recessive disorder of copper (Cu) metabolism...
  79. ncbi [Acquired von Willebrand syndrome]
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera, Verona
    Recenti Prog Med 97:417-21; quiz 440. 2006
    ..The main pathogenic, clinical, laboratory and therapeutic aspects of this syndrome are concisely reported in this review...
  80. pmc Comparison of JAK2V617F mutation assessment employing different molecular diagnostic techniques
    Dino Veneri
    Dipartimento di Medicina Sperimentale e Clinica, Sezione di Ematologia, Universita di Verona, Verona, Italy
    Blood Transfus 7:204-9. 2009
    ..In this study we compare the results of JAK2(V617F) mutation detection using three different molecular techniques in the same group of patients affected by essential thrombocythaemia...
  81. doi Coagulation testing in pediatric patients: the young are not just miniature adults
    Giuseppe Lippi
    Dipartimento di Scienze Biomediche e Morfologiche, Universita di Verona, Verona, Italy
    Semin Thromb Hemost 33:816-20. 2007
    ....
  82. doi Acquired factor VIII inhibitors in oncohematology: a systematic review
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Ospedale Policlinico, and Dipartimento di Scienze Biomediche e Chirurgiche, Universita di Verona, Piazzale Ludovico Scuro, 37134 Verona, Italy
    Crit Rev Oncol Hematol 66:194-9. 2008
    ..Based on electronic and hand searches of the published literature, this systematic review examines the current knowledge on factor VIII autoantibodies associated with oncohematological disorders...
  83. doi Inherited and acquired risk factors for arterial ischemic stroke in childhood
    Giuseppe Lippi
    Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita di Verona, Ospedale Policlinico G B Rossi, Piazzale Scuro, 10, 37134 Verona, Italy
    J Thromb Thrombolysis 27:239-48. 2009
    ....
  84. pmc Peripheral blood CD5-positive B lymphocytes (B-1a cells) after allogeneic stem cell transplantation for acute myeloid leukaemia in humans
    Dino Veneri
    Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Universita di Verona, Italy
    Blood Transfus 6:220-4. 2008
    ..Only few data are available in literature regarding the reconstitution of B- 1a cells after allogeneic bone marrow transplantation performed for haematological malignancies...
  85. ncbi TCF2 gene mutation leads to nephro-urological defects of unequal severity: an open question
    Marco Zaffanello
    Department of Mother Child and Biology Genetics, University of Verona GB Rossi Hospital, Piazzale Lo Scuro 10, Verona, Italy
    Med Sci Monit 14:RA78-86. 2008
    ....
  86. doi Genetic and biochemical heterogeneity of cardiac troponins: clinical and laboratory implications
    Giuseppe Lippi
    Section of Clinical Chemistry, University Hospital of Verona, Verona, Italy
    Clin Chem Lab Med 47:1183-94. 2009
    ....
  87. pmc Expression of CD27 and CD23 on peripheral blood B lymphocytes in humans of different ages
    Dino Veneri
    Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Universita di Verona, Italia
    Blood Transfus 7:29-34. 2009
    ..B cells were also distinguished into B2 (CD5-) and B1-a cells (CD5+)...
  88. doi Hidden high-grade vesicoureteral reflux is the main risk factor for chronic renal damage in children under the age of two years with first urinary tract infection
    Marco Zaffanello
    Department of Mother Child and Biology Genetics, University of Verona, Verona, Italy
    Scand J Urol Nephrol 43:494-500. 2009
    ..The aim of the present prospective trial was to investigate, in a cohort of young children with first urinary tract infection (UTI) and negative prenatal history, the role of imaging in screening babies at risk of renal deterioration...
  89. pmc Increased risk of CKD among type 2 diabetics with nonalcoholic fatty liver disease
    Giovanni Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University of Verona, Ospedale Civile Maggiore, Piazzale Stefani, 1, 37126 Verona, Italy
    J Am Soc Nephrol 19:1564-70. 2008
    ..1 to 2.2; P < 0.01). In conclusion, our findings suggest that nonalcoholic fatty liver disease is associated with an increased incidence of CKD in individuals with type 2 diabetes, independent of numerous baseline confounding factors...
  90. doi Prevalence of thyroid autoimmunity and subclinical hypothyroidism in persons with chronic kidney disease not requiring chronic dialysis
    Giovanni Targher
    Section of Endocrinology, Department of Biomedical and Surgical Sciences, University Hospital of Verona, Verona, Italy
    Clin Chem Lab Med 47:1367-71. 2009
    ..The prevalence of thyroid autoimmunity and subclinical primary hypothyroidism in persons with chronic kidney disease (CKD) not requiring chronic dialysis is not well defined...
  91. doi Thrombotic complications of erythropoiesis-stimulating agents
    Giuseppe Lippi
    U O di Diagnostica Ematochimica, Azienda Ospedaliero Universitaria di Parma, Parma, Italy
    Semin Thromb Hemost 36:537-49. 2010
    ....
  92. ncbi Is time to treat for HCV all the HIV/HCV co-infected hemophiliacs?
    Massimo Franchini
    Hemophilia Center, City Hospital of Verona, Verona, Italy
    Hematology 11:209-13. 2006
    ..In this concise review, the current knowledge as regards the management of HCV infection in HIV co-infected hemophiliacs is analyzed...
  93. pmc The management of hemophilia in elderly patients
    Massimo Franchini
    Transfusion and Hemophilia Center, City Hospital of Verona, Italy
    Clin Interv Aging 2:361-8. 2007
    ....
  94. ncbi Lipoprotein[a] and cancer: anti-neoplastic effect besides its cardiovascular potency
    Giuseppe Lippi
    Sezione di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Ospedale Policlinico G B Rossi, Piazzale Scuro 10, 37134 Verona, Italy
    Cancer Treat Rev 33:427-36. 2007
    ..This review is focused on the biochemical structure, metabolism and the anti-angiogenic activity of this unique and elusive kringle-containing lipoprotein...
  95. ncbi Advances in the diagnosis and management of von Willebrand disease
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy
    Hematology 11:219-25. 2006
    ..In this review, the present knowledge regarding the diagnosis and the management of VWD is briefly analyzed...
  96. ncbi Changes of human B and B-1a peripheral blood lymphocytes with age
    Dino Veneri
    Section of Hematology, Department of Clinical and Experimental Medicine, University of Verona, Verona, Italy
    Hematology 12:337-41. 2007
    ..Possible physiological explanations and/or implications for the disease states are taken into account...
  97. pmc Relationship between ABO blood group and von Willebrand factor levels: from biology to clinical implications
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Thromb J 5:14. 2007
    ..In this review, the most recent advances in our understanding of the mechanisms by which ABO blood group determines plasma VWF levels and their clinical impact will be discussed...
  98. ncbi Postpartum acquired factor VIII inhibitors
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Azienda Ospedaliera di Verona, Verona, Italy
    Am J Hematol 81:768-73. 2006
    ..Based on an analysis of the literature, this review presents the current knowledge on the pathogenesis, diagnosis, epidemiology, natural history, clinical manifestations, and therapeutic management of postpartum acquired hemophilia A...
  99. ncbi Recent acquisitions in acquired and congenital von Willebrand disorders
    Massimo Franchini
    Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera Policlinico, Piazzale L Scuro, and Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Biomediche e Morfologiche, Universita di Verona, Italy
    Clin Chim Acta 377:62-9. 2007
    ..Its deficiency is associated with a bleeding tendency. The progresses in the pathophysiology, diagnosis and management of inherited von Willebrand disease and acquired von Willebrand syndrome will be discussed in this review...
  100. ncbi The use of recombinant activated factor VII in obstetric and gynaecological haemorrhage
    M Franchini
    Servizio di Immunoematologia e Trasfusione Centro Emofilia, Ospedale Policlinico Azienda Ospedaliera di Verona, Verona, Italy
    BJOG 114:8-15. 2007
    ..However, further evidence is needed to improve the assessment of its optimal dose, effectiveness and safety in such conditions...
  101. ncbi [Preoperative laboratory testing]
    G Lippi
    Unità di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico Biomediche, Universita degli Studi di Verona, Verona, Italy
    Minerva Med 96:397-407. 2005
    ..This article aims to provide a comprehensive review of the current literature on this topic, attempting to suggest a suitable approach to the puzzling issue of preoperative laboratory testing...