A Franchi

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi request reprint Low Prevalence of K-RAS, EGF-R and BRAF Mutations in Sinonasal Adenocarcinomas. Implications for Anti-EGFR Treatments
    Alessandro Franchi
    Section of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy
    Pathol Oncol Res 20:571-9. 2014
  2. doi request reprint The contribution of electron microscopy to the characterization of soft tissue fibrosarcomas
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
    Ultrastruct Pathol 37:9-14. 2013
  3. doi request reprint Primary juxtacortical myoepithelioma/mixed tumor of the bone: a report of 3 cases with clinicopathologic, immunohistochemical, ultrastructural, and molecular characterization
    Alessandro Franchi
    Division of Anatomic Pathology, Department of Critical Care Medicine and Surgery, University of Florence Medical School, 50134, Florence, Italy
    Hum Pathol 44:566-77. 2013
  4. doi request reprint Dedifferentiated peripheral chondrosarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of four cases
    Alessandro Franchi
    Division of Anatomic Pathology, Department of Critical Care Medicine and Surgery, University of Florence Medical School, Viale G B Morgagni 85, 50134 Florence, Italy
    Virchows Arch 460:335-42. 2012
  5. ncbi request reprint Dilation of intercellular spaces is associated with laryngo-pharyngeal reflux: an ultrastructural morphometric analysis of laryngeal epithelium
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Viale G B Morgagni 85, 50134, Firenze, Italy
    Eur Arch Otorhinolaryngol 264:907-11. 2007
  6. ncbi request reprint Expression of p16 in sinonasal malignant melanoma
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Viale G B Morgagni 85, 50134 Florence, Italy
    Virchows Arch 449:667-72. 2006
  7. ncbi request reprint Radiation-induced cutaneous carcinoma of the head and neck: is there an early role for p53 mutations?
    A Franchi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Clin Exp Dermatol 31:793-8. 2006
  8. ncbi request reprint Tumor lymphangiogenesis in head and neck squamous cell carcinoma: a morphometric study with clinical correlations
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    Cancer 101:973-8. 2004
  9. ncbi request reprint Inducible nitric oxide synthase activity correlates with lymphangiogenesis and vascular endothelial growth factor-C expression in head and neck squamous cell carcinoma
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    J Pathol 208:439-45. 2006
  10. ncbi request reprint Central low-grade osteosarcoma with pagetoid bone formation: a potential diagnostic pitfall
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Mod Pathol 17:288-91. 2004

Detail Information

Publications84

  1. ncbi request reprint Low Prevalence of K-RAS, EGF-R and BRAF Mutations in Sinonasal Adenocarcinomas. Implications for Anti-EGFR Treatments
    Alessandro Franchi
    Section of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy
    Pathol Oncol Res 20:571-9. 2014
    ....
  2. doi request reprint The contribution of electron microscopy to the characterization of soft tissue fibrosarcomas
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
    Ultrastruct Pathol 37:9-14. 2013
    ....
  3. doi request reprint Primary juxtacortical myoepithelioma/mixed tumor of the bone: a report of 3 cases with clinicopathologic, immunohistochemical, ultrastructural, and molecular characterization
    Alessandro Franchi
    Division of Anatomic Pathology, Department of Critical Care Medicine and Surgery, University of Florence Medical School, 50134, Florence, Italy
    Hum Pathol 44:566-77. 2013
    ..The clinicoradiologic presentation and their histological and immunohistochemical features are distinctive enough to allow the separation from these entities...
  4. doi request reprint Dedifferentiated peripheral chondrosarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of four cases
    Alessandro Franchi
    Division of Anatomic Pathology, Department of Critical Care Medicine and Surgery, University of Florence Medical School, Viale G B Morgagni 85, 50134 Florence, Italy
    Virchows Arch 460:335-42. 2012
    ..PDGFRβ could represent a potential target for treatments with receptor tyrosine kinase inhibitors in peripheral DCS...
  5. ncbi request reprint Dilation of intercellular spaces is associated with laryngo-pharyngeal reflux: an ultrastructural morphometric analysis of laryngeal epithelium
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Viale G B Morgagni 85, 50134, Firenze, Italy
    Eur Arch Otorhinolaryngol 264:907-11. 2007
    ..If this result will be confirmed in larger series it may provide a useful diagnostic tool for the identification of LPR...
  6. ncbi request reprint Expression of p16 in sinonasal malignant melanoma
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Viale G B Morgagni 85, 50134 Florence, Italy
    Virchows Arch 449:667-72. 2006
    ..At variance from cutaneous melanoma, loss of p16 is not correlated with the prognosis of patients affected by sinonasal melanoma...
  7. ncbi request reprint Radiation-induced cutaneous carcinoma of the head and neck: is there an early role for p53 mutations?
    A Franchi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Clin Exp Dermatol 31:793-8. 2006
    ..Little is known about the molecular mechanisms underlying ionizing radiation-induced carcinogenesis of the skin...
  8. ncbi request reprint Tumor lymphangiogenesis in head and neck squamous cell carcinoma: a morphometric study with clinical correlations
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    Cancer 101:973-8. 2004
    ..In the current study, the authors investigated whether tumor lymphangiogenesis may be related to the risk of lymph node metastasis and to clinical outcome in patients with HNSCC...
  9. ncbi request reprint Inducible nitric oxide synthase activity correlates with lymphangiogenesis and vascular endothelial growth factor-C expression in head and neck squamous cell carcinoma
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    J Pathol 208:439-45. 2006
    ..Taken together, our results indicate that iNOS activity may promote lymphangiogenesis and spread to lymph nodes in HNSCC, with the possible involvement of VEGF-C...
  10. ncbi request reprint Central low-grade osteosarcoma with pagetoid bone formation: a potential diagnostic pitfall
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Mod Pathol 17:288-91. 2004
    ..Recognition of this variant of central low-grade osteosarcoma is based on the aggressive radiologic appearance and on adequate tumor sampling for histologic examination...
  11. doi request reprint Current diagnostic strategies for undifferentiated tumours of the nasal cavities and paranasal sinuses
    Alessandro Franchi
    Division of Anatomic Pathology, Department of Critical Care Medicine and Surgery, University of Florence Medical School, Florence, Italy
    Histopathology 59:1034-45. 2011
    ....
  12. doi request reprint Immunohistochemical investigation of tumorigenic pathways in sinonasal intestinal-type adenocarcinoma. A tissue microarray analysis of 62 cases
    Alessandro Franchi
    Division of Anatomic Pathology, Department of Critical Care Medicine and Surgery, University of Florence Medical School, Florence, Italy
    Histopathology 59:98-105. 2011
    ....
  13. ncbi request reprint CDX-2, cytokeratin 7 and cytokeratin 20 immunohistochemical expression in the differential diagnosis of primary adenocarcinomas of the sinonasal tract
    A Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    Virchows Arch 445:63-7. 2004
    ..Staining for CDX-2 and cytokeratin 20 has potential use in separating ITACs from other primary malignant glandular neoplasms of the nasal cavities and paranasal sinuses...
  14. ncbi request reprint Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns
    Alessandro Franchi
    Department of Human Pathology and Oncology, Medical School, University of Florence, Viale G B Morgagni 85, 50134 Florence, Italy
    Am J Surg Pathol 26:1597-604. 2002
    ..Moreover, these findings support the hypothesis that SNUC is a separate entity from SCC and NPTC of the sinonasal tract...
  15. ncbi request reprint Inducible nitric oxide synthase expression in laryngeal neoplasia: correlation with angiogenesis
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Viale G B Morgagni 85, 50134 Florence, Italy
    Head Neck 24:16-23. 2002
    ..The aim of this study was to assess whether the NO pathway may be correlated with angiogenesis in the transition from laryngeal dysplasia to invasive carcinoma...
  16. ncbi request reprint Expression of matrix metalloproteinase 1, matrix metalloproteinase 2, and matrix metalloproteinase 9 in carcinoma of the head and neck
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    Cancer 95:1902-10. 2002
    ....
  17. doi request reprint Pediatric sinonasal neuroendocrine carcinoma after treatment of retinoblastoma
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, 50134 Florence, Italy
    Hum Pathol 40:750-5. 2009
    ..These tumors represent a peculiar subset of undifferentiated sinonasal neoplasms with extremely aggressive clinical behavior...
  18. doi request reprint CD105/endoglin expression in Gorham disease of bone
    A Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    J Clin Pathol 62:163-7. 2009
    ....
  19. ncbi request reprint TGF-beta isoform and receptor expression in giant cell tumor and giant cell lesions of bone
    A Franchi
    Department of Human Pathology and Oncology, University of Florence Medical School, Italy
    Appl Immunohistochem Mol Morphol 9:170-5. 2001
    ....
  20. doi request reprint Epidermal growth factor receptor expression and gene copy number in sinonasal intestinal type adenocarcinoma
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Firenze, Italy
    Oral Oncol 45:835-8. 2009
    ..EGFR targeted therapies could therefore be investigated prospectively in this group of tumors...
  21. ncbi request reprint Multiple primary tumors of the upper aerodigestive tract: is there a role for constitutional mutations in the p53 gene?
    O Gallo
    Institute of Otolaryngology Head and Neck Surgery, University of Florence, Italy
    Int J Cancer 82:180-6. 1999
    ..Abnormal expression of wild-type p53 protein in normal and pathological tissues from patients with the same sense single-nucleotide substitutions was detected by immuno-histochemistry...
  22. ncbi request reprint Limb salvage surgery in combination with brachytherapy and external beam radiation for high-grade soft tissue sarcomas
    G Beltrami
    Department of Orthopaedic Oncology, University of Florence, Careggi, Florence, Italy
    Eur J Surg Oncol 34:811-6. 2008
    ..Using our treatment algorithm for high-grade soft tissue sarcoma of the extremities, good local and systemic control can be achieved with a low complication rate...
  23. pmc Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis
    O Gallo
    Department of Oto Neuro Ophthalmologic Surgery, University of Florence, 50139 Florence, Italy
    Neoplasia 3:53-61. 2001
    ..This study suggests a central role of COX-2 pathway in HNC angiogenesis by modulating VEGF production and indicates that COX-2 inhibitors may be useful in HNC treatment...
  24. ncbi request reprint Histopathological re-classification of extremity pleomorphic soft tissue sarcoma has clinical relevance
    D Massi
    Department of Human Pathology and Oncology, University of Florence, Viale G B Morgagni 85, 50134 Florence, Italy
    Eur J Surg Oncol 30:1131-6. 2004
    ....
  25. ncbi request reprint Inducible nitric oxide synthase expression in benign and malignant cutaneous melanocytic lesions
    D Massi
    Dipartimento di Patologia Umana ed Oncologia, , Firenze, Italy
    J Pathol 194:194-200. 2001
    ..These data suggest that iNOS may play a role in the malignant transformation of melanocytes and in tumour growth. In addition, iNOS may be useful as an immunohistochemical marker for malignant melanocytic lesions...
  26. pmc Downregulation of transforming growth factor beta type II receptor in laryngeal carcinogenesis
    A Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    J Clin Pathol 54:201-4. 2001
    ..TGF-beta RII status was examined in laryngeal premalignant lesions coupled with malignant evolution and compared with a control group of similar lesions without progression to cancer...
  27. ncbi request reprint Microsatellite instability as biomarker for risk of multiple primary malignancies of the upper aerodigestive tract
    I Sardi
    Medical Genetics Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Oncol Rep 8:393-9. 2001
    ....
  28. pmc Tumour lymphangiogenesis is a possible predictor of sentinel lymph node status in cutaneous melanoma: a case-control study
    D Massi
    Department of Human Pathology and Oncology, University of Florence, I 50134 Florence, Italy
    J Clin Pathol 59:166-73. 2006
    ..Cutaneous melanoma spreads preferentially through the lymphatic route and sentinel lymph node (SLN) status is regarded as the most important predictor of survival...
  29. ncbi request reprint Soft tissue sarcomas of the popliteal fossa: outcome and risk factors
    H A Rüdiger
    Department of Orthopaedic Oncology, University of Florence, Careggi, Florence, Italy
    Eur J Surg Oncol 33:512-7. 2007
    ..The scope of this study was to determine outcome and to define risk factors...
  30. ncbi request reprint Correlation between nitric oxide and cyclooxygenase-2 pathways in head and neck squamous cell carcinomas
    Oreste Gallo
    Department of Oto Neuro Ophthalmologic Surgery, University of Florence Medical School, 50134 Florence, Italy
    Biochem Biophys Res Commun 299:517-24. 2002
    ..Thus, in squamous carcinoma cells, NO increases the activity of COX-2 pathway and this effect is probably mediated by endocellular cGMP level, with potential implications on tumor growth, angiogenesis, and therapy...
  31. ncbi request reprint Expression of CD44 standard and variant isoforms in parotid gland and parotid gland tumours
    A Franchi
    Department of Human Pathology and Oncology, University of Florence Medical School, Viale G.B. Morgagni 85, 50134 Florence, Italy
    J Oral Pathol Med 30:564-8. 2001
    ....
  32. ncbi request reprint Expression and prognostic significance of matrix metalloproteinases and their tissue inhibitors in primary neuroendocrine carcinoma of the skin
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Hum Pathol 34:80-8. 2003
    ..It is conceivable that future attempts to specifically block MMP-1 and MMP-3 activity may provide a novel means to inhibit invasiveness and distant spread in selected patients with PNC...
  33. doi request reprint Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions
    Clelia Miracco
    Department of Human Pathology and Oncology, University of Siena, 53100 Siena, Italy
    Hum Pathol 41:503-12. 2010
    ..Our results, therefore, indicate that beclin 1 and LC3 II autophagic gene expression is altered also in melanocytic neoplasms...
  34. ncbi request reprint Submicroscopic and immunohistochemical profile of surface osteosarcomas
    A Franchi
    Institute of Anatomic Pathology, University of Florence Medical School, Italy
    Ultrastruct Pathol 23:233-40. 1999
    ..Further, the myofibroblast-like cells that are present in variable numbers in these tumors are probably modified osteoblasts, since they co-express actin, osteonectin, and osteocalcin...
  35. ncbi request reprint Microsatellite analysis in cutaneous malignant melanoma
    D Massi
    Department of Human Pathology and Oncology, Medical Genetics Unit, University of Florence, Italy
    Melanoma Res 12:577-84. 2002
    ..Genetic analysis of metastatic lesions revealed that the same microsatellite alterations as in the primary tumour are seen, but additional genetic changes may develop during disease progression...
  36. ncbi request reprint Vasculogenic mimicry has no prognostic significance in pT3 and pT4 cutaneous melanoma
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Hum Pathol 35:496-502. 2004
    ..05). In conclusion, our results suggest that there is a mismatch between vasculogenic mimicry and tumor angiogenesis and do not support any prognostic role of vasculogenic mimicry in thick cutaneous melanoma...
  37. ncbi request reprint Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma
    Oreste Gallo
    Department of Oto Neuro Ophthalmologic Surgery, University of Florence Medical School, Florence, Italy
    Hum Pathol 33:708-14. 2002
    ..In addition, COX-2 overexpression and higher tumor vascularization appear to predict a shorter survival in patients with head and neck cancer...
  38. doi request reprint Inducible nitric oxide synthase expression in melanoma: implications in lymphangiogenesis
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Mod Pathol 22:21-30. 2009
    ..Mechanistic studies are needed to address the possibility that inducible nitric oxide synthase controls lymphangiogenesis, dissemination and lymphatic borne metastases...
  39. ncbi request reprint Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumors
    Daniela Massi
    Dipartimento di Patologia Umana ed Oncologia, Universita di Firenze, Florence 50134, Italy
    Hum Pathol 38:1516-25. 2007
    ..However, macrophages stimulated by murine melanoma cells secreted a level of NO compatible with an antitumor activity only in the presence of interferon gamma...
  40. doi request reprint Primitive testicular leiomyosarcoma
    Maria Rosaria Raspollini
    Department of Human Pathology and Oncology, University of Florence Careggi Hospital, Viale G B Morgagni, 85, 50134 Florence, Italy
    Pathol Oncol Res 16:177-9. 2010
    ..In older people there are apparently no risk factors. We describe one further case in a 77-years old man with full histological and ultrastructural evaluation. A short term follow-up of one year signals no recurrence of the disease...
  41. doi request reprint Congenital/Infantile fibrosarcoma of the colon: morphologic, immunohistochemical, molecular, and ultrastructural features of a relatively rare tumor in an extraordinary localization
    Anna Maria Buccoliero
    Department of Human Pathology and Oncology, University of Florence, Careggi Hospital, Firenze, Italy
    J Pediatr Hematol Oncol 30:723-7. 2008
    ..The algorithm for the diagnosis of congenital/infantile fibrosarcoma, especially outside the usual localizations, should comprise morphologic, immunohistochemical, molecular, and ultrastructural studies...
  42. doi request reprint Embryonal tumor with abundant neuropil and true rosettes: morphological, immunohistochemical, ultrastructural and molecular study of a case showing features of medulloepithelioma and areas of mesenchymal and epithelial differentiation
    Anna Maria Buccoliero
    Department of Biomedicine, Careggi Hospital, 50134 Florence, Italy
    Neuropathology 30:84-91. 2010
    ..Owing to the rarity of embryonal tumor with abundant neuropil and true rosettes, each new case should be recorded to produce a better clinical, pathological and molecular characterization of this lesion...
  43. doi request reprint Recognizing hidden phenotypes in sarcomas through the electron microscope
    Marco Santucci
    Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
    Ultrastruct Pathol 32:51-61. 2008
    ..Occasionally, in tumors with smooth muscle, skeletal muscle, adipocytic, vascular endothelial, and Schwann cell differentiation electron microscopy may help in the differential diagnosis...
  44. doi request reprint Genetic alterations between primary head and neck squamous cell carcinoma and recurrence after radiotherapy: recurrence, genetically related cancer, or second primary?
    Alberto Deganello
    Department of Otolaryngology Head and Neck Surgery, University of Florence, Florence, Italy
    Cancer 116:1291-7. 2010
    ..In the attempt to characterize the genetic bases of recurrent head and neck squamous cell carcinoma (HNSCC) after radiotherapy (RT), the authors compared the molecular profiles of primary tumors and recurrences...
  45. doi request reprint Primary cutaneous leiomyosarcoma: clinicopathological analysis of 36 cases
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Histopathology 56:251-62. 2010
    ..The aim was to verify whether the clinical behaviour of purely dermal LMS is different from that of LMS with minimal subcutis invasion...
  46. ncbi request reprint Primary cutaneous osteosarcoma of the scalp: a case report and review of the literature
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    J Cutan Pathol 34:61-4. 2007
    ..The clinico-pathological features of the case are discussed in light of the rare cases previously described in the literature...
  47. ncbi request reprint Persistent contrast enhancement by sterically stabilized paramagnetic liposomes in murine melanoma
    Ivano Bertini
    Magnetic Resonance Center CERM, University of Florence, Italy
    Magn Reson Med 52:669-72. 2004
    ..High persistence of the CA was also observed in the liver and intestine, as expected in a hepatobiliar excretion pathway...
  48. ncbi request reprint Epidermal growth factor receptor and p53 expression in T1-T2 glottic cancer involving the anterior or posterior commissure
    Lucio Rucci
    Departments of Otolaryngology Head and Neck Surgery, University of Florence, Florence, Italy
    Acta Otolaryngol 124:102-6. 2004
    ....
  49. ncbi request reprint The comparative role of immunohistochemistry and electron microscopy in the identification of myogenic differentiation in soft tissue pleomorphic sarcomas
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
    Ultrastruct Pathol 29:295-304. 2005
    ..In conclusion, the results indicate that immunohistochemistry and electron microscopy can usefully complement each other in the classification of soft tissue pleomorphic sarcomas...
  50. ncbi request reprint Hyalinizing spindle cell tumor with giant rosettes and low-grade fibromyxoid sarcoma: an immunohistochemical and ultrastructural comparative investigation
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
    Ultrastruct Pathol 27:349-55. 2003
    ....
  51. ncbi request reprint Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Mod Pathol 19:246-54. 2006
    ..These results indicate that the activation of Notch may represent an early event in melanocytic tumor growth and upregulation of Notch signaling may sustain tumor progression...
  52. pmc Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation of hERG1 channels and of the VEGF-A pathway
    Pina Fortunato
    Department of Experimental Pathology and Oncology, University of Florence Viale G, B, Morgagni, Florence Italy
    BMC Cancer 10:504. 2010
    ....
  53. doi request reprint Nodal metastases at level IIb during neck dissection for head and neck cancer: clinical and pathologic evaluation
    Roberto Santoro
    Department of Oto Neuro Ophtalmological Surgical Sciences, University of Florence, Florence, Italy
    Head Neck 30:1483-7. 2008
    ..The aim of this study was to verify the incidence of metastases at level IIb in patients with clinically negative necks (N0) and clinically positive necks (N+) and discuss the need for its excision...
  54. pmc Down-regulation of nitric oxide synthase-2 and cyclooxygenase-2 pathways by p53 in squamous cell carcinoma
    Oreste Gallo
    Department of Oto Neuro Ophthalmologic Surgery, University of Florence, Florence, Italy
    Am J Pathol 163:723-32. 2003
    ....
  55. doi request reprint Subependymal giant cell astrocytoma (SEGA): Is it an astrocytoma? Morphological, immunohistochemical and ultrastructural study
    Anna M Buccoliero
    Department of Human Pathology and Oncology, University of Florence, Italy
    Neuropathology 29:25-30. 2009
    ..Our results emphasize the glio-neuronal nature of SEGA. We suggest moving it into the group of mixed glio-neuronal tumors under the denomination of subependymal giant cell tumor...
  56. doi request reprint Pediatric rhabdoid meningioma: a morphological, immunohistochemical, ultrastructural and molecular case study
    Anna Maria Buccoliero
    Department of Biomedicine, Careggi Hospital, Florence, Italy
    Neuropathology 31:59-65. 2011
    ..Rhabdoid meningiomas rarely occur in children. Owing to its rarity, each new case should be recorded to produce a better clinical, pathological, molecular, prognostic and therapeutic characterization of this lesion...
  57. ncbi request reprint Cerebellar liponeurocytoma: immunohistochemical and ultrastructural study of a case
    G L Taddei
    Department of Human Pathology and Oncology, University of Florence, Italy
    Ultrastruct Pathol 25:59-63. 2001
    ..The present study provides the first description of a less differentiated and histologically more aggressive form of this unusual tumor...
  58. doi request reprint First bite syndrome as presenting symptom of parapharyngeal adenoid cystic carcinoma
    A Deganello
    Otolaryngology Head and Neck Surgery Clinic, Department of Surgical Sciences, University of Florence, Italy
    J Laryngol Otol 125:428-31. 2011
    ..First bite syndrome refers to the development of pain in the parotid region after the first bite of each meal...
  59. ncbi request reprint Clinical characteristics and overall survival in genitourinary sarcomas treated with curative intent: a multicenter study
    N Mondaini
    Department of Urology, University of Florence, Viale Pieraccini 18, 50100 Florence, Italy
    Eur Urol 47:468-73. 2005
    ..We report our experience with this type of tumours in a multicenter study carried out in a single region of Central Italy (Tuscany)...
  60. doi request reprint A morphologic and immunohistochemical study of nasal mucosa in leatherworkers
    Annarita Palomba
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Am J Rhinol 22:356-60. 2008
    ..The purpose of this study was to investigate the histological changes and modifications in the phenotype of epithelial cells in nasal mucosa of leather workers...
  61. ncbi request reprint Expression of cyclo-oxygenase-2 in macrophages associated with cutaneous melanoma at different stages of progression
    Francesca Bianchini
    Department of Experimental Pathology and Oncology, University of Florence, Viale G B Morgagni 50, I 50134 Florence, Italy
    Prostaglandins Other Lipid Mediat 83:320-8. 2007
    ..On the whole, the results of in vivo and in vitro studies suggest that COX-2 expressed in TAMs appears to act as an effective biomarker of melanoma progression, and melanoma cells themselves might stimulate COX-2 in macrophages...
  62. ncbi request reprint Stomal recurrence following total laryngectomy: clinical and molecular analysis of a series
    Roberto Santoro
    Department of Oto neuro ophthalmologic Surgical Sciences, University of Florence, Florence, Italy
    Ann Otol Rhinol Laryngol 112:594-9. 2003
    ..Our analysis supports the hypothesis that a subset of SRs after TL may be second primary tumors, genetically unrelated to the primary laryngeal lesion...
  63. ncbi request reprint Prognostic factors in soft tissue leiomyosarcoma of the extremities: a retrospective analysis of 42 cases
    D Massi
    Department of Human Pathology and Oncology, University of Florence, Viale Morgagni, 85, 50134 Firenze, Italy
    Eur J Surg Oncol 30:565-72. 2004
    ..The goals of the present study were to describe the clinico-pathological and prognostic features of 42 patients affected by soft tissue LMS of the extremities...
  64. ncbi request reprint Sclerosing variant of PEComa: report of a case and review of the literature
    R Santi
    Division of Pathological Anatomy, University of Florence, Florence, Italy
    Histol Histopathol 27:1175-81. 2012
    ..Light and electron microscopy were performed, along with immunohistochemical analysis. Further studies are needed to clarify the histogenesis and to predict the biological behaviour of this uncommon entity...
  65. ncbi request reprint Expression of protease-activated receptor-1 and -2 in orofacial granulomatosis
    S Ketabchi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Oral Dis 13:419-25. 2007
    ..Protease-Activated Receptors (PARs) play a role in inflammatory diseases in diverse human tissues. The aim of the study was to investigate the expression of PAR-1, PAR-2, MMP-2, MMP-9, COX-1, and COX-2 in tissues taken from OFG patients...
  66. doi request reprint A novel recessive mutation of fibroblast growth factor-23 in tumoral calcinosis
    L Masi
    Department of Internal Medicine, University Hospital of Florence, Florence, Italy
    J Bone Joint Surg Am 91:1190-8. 2009
    ..Mutational analysis is important for the early recognition of the disorder, for prevention of its complications, and for family screening strategies. We examined two unrelated white patients affected by tumoral calcinosis...
  67. ncbi request reprint Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Hum Pathol 36:676-85. 2005
    ..Conversely, the significance of PAR-2 up-regulation in both benign and malignant melanocytic lesions requires further research...
  68. ncbi request reprint Congenital laterocervical complex masses: Are they all lymphangiomas?
    Antonio Messineo
    Pediatric Surgery, Hospital for Sick Children, Florence, Italy
    J Pediatr 147:121. 2005
  69. ncbi request reprint Expression of cyclooxygenase-2 in osteosarcoma of bone
    Laura Masi
    Department of Internal Medicine, University of Florence, Florence, Italy
    Appl Immunohistochem Mol Morphol 15:70-6. 2007
    ..These results indicate that COX-2 is expressed at high levels in high grade osteosarcomas and support the use of COX-2 inhibitors to improve both the tumor response to chemotherapy and the outcome of osteosarcoma patients...
  70. ncbi request reprint Tumor angiogenesis as a prognostic factor in thick cutaneous malignant melanoma. A quantitative morphologic analysis
    Daniela Massi
    Dipartimento di Patologia Umana ed Oncologia, Universita degli Studi di Firenze, Florence, Italy
    Virchows Arch 440:22-8. 2002
    ..Its prognostic significance is better assessed by quantification of vessel area, equivalent circle diameter, and microvessel branching, whereas microvessel count and vascular density do not provide significant prognostic information...
  71. ncbi request reprint Adipofascial anterolateral thigh free flap for tongue repair
    V Agostini
    Department of Plastic Surgery, University of Florence, C T O, Largo Palagi 1, Florence 50139, Italy
    Br J Plast Surg 56:614-8. 2003
    ..The histological features of the flaps were investigated postoperatively. Although this preliminary report has to be confirmed by further experience, it seems to solve many tongue-reconstruction related problems...
  72. doi request reprint Synovial chondrosarcoma of the hip: report of two cases and literature review
    Domenico Andrea Campanacci
    Department of Orthopaedic Oncology, Centro Traumatologico Ortopedico, Azienda Ospedaliera Universitaria Careggi, Largo Palagi 1, Florence, Italy
    Chir Organi Mov 92:139-44. 2008
    ..An early detection of malignant transformation of SC might improve the rate of limb salvage surgery in these patients, although no reliable clinical and imaging signs of malignant degeneration have been identified so far...
  73. ncbi request reprint Microsatellite instability as an indicator of malignant progression in laryngeal premalignancy
    Iacopo Sardi
    Oncohaematology Unit, Department of Pediatrics, University of Florence, Florence, Italy
    Head Neck 28:730-9. 2006
    ..Microsatellite instability (MSI) is considered a novel marker of genetic instability, and preliminary studies have shown that it may provide useful information in assessing the risk of malignant progression in preinvasive lesions...
  74. ncbi request reprint Transforming growth factor-beta isoform and receptor expression in chondrosarcoma of bone
    Laura Masi
    Endocrine Unit, University of Florence Medical School, Florence, Italy
    Virchows Arch 440:491-7. 2002
    ..004, log-rank test). Our data indicate that TGF-beta isoforms are produced by neoplastic cells of chondrosarcomas and could have a potential role as autocrine growth stimulators in these neoplasms...
  75. ncbi request reprint Glandular hamartoma of the larynx: report of a case
    Giuseppe Leoncini
    Department of Human Pathology and Oncology, University of Florence, Viale G B, Morgagni 85, 50134, Florence, Italy
    Auris Nasus Larynx 35:149-51. 2008
    ..The aim of our report is to underline how this condition must be considered by physicians, paediatricians and anaesthetists as an important cause of airway obstruction...
  76. doi request reprint Orbital solitary fibrous tumor: a case report and review of the literature
    Giuseppe Leoncini
    Department of Human Pathology and Oncology, University of Florence, Viale GB Morgagni 85, 50134, Florence, Italy
    Pathol Oncol Res 14:213-7. 2008
    ..We review the clinical, histopathological, and immunohistochemical features of the orbital SFT described so far, with particular emphasis on differential diagnosis with other spindle cell orbital neoplasms...
  77. doi request reprint Cutaneous carcinosarcoma: report of a case with myofibroblastic sarcomatous component
    Tommaso Agostini
    Department of Plastic Surgery, Florence, Italy
    Dermatol Surg 34:418-22; discussion 422. 2008
  78. ncbi request reprint Paraganglioma of the nasal cavity: a case report
    Sheyda Ketabchi
    Dipartimento di Patologia Umana ed Oncologia, Universita degli Studi di Firenze, Viale G B Morgagni 85, 50134, Firenze, Italia
    Eur Arch Otorhinolaryngol 260:336-40. 2003
    ..We report on the clinical, histopathological and immunohistochemical findings of our case and review the cases previously described in the literature...
  79. ncbi request reprint Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells
    Santiago Ropero
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre, Madrid, Spain
    Hum Mol Genet 13:2753-65. 2004
    ..These findings highlight the importance of EXT1 epigenetic inactivation, leading to an abrogation of HS biosynthesis, in the processes of tumor onset and progression...
  80. ncbi request reprint An osteoclast-rich tumor of the gastrointestinal tract with features resembling clear cell sarcoma of soft parts: reports of 6 cases of a GIST simulator
    Eduardo Zambrano
    Department of Pathology, Yale University Medical School, New Haven, CT, USA
    Int J Surg Pathol 11:75-81. 2003
    ....
  81. ncbi request reprint CDX-2 homeobox gene expression
    Alessandro Franchi
    Am J Surg Pathol 27:1390-1. 2003
  82. ncbi request reprint A ribonuclease protection assay-based approach for analysis of angiogenic gene expression in archival tissues
    Antonella Naldini
    Department of Physiology, University of Siena, Italy
    Diagn Mol Pathol 16:147-52. 2007
    ..In conclusion, our study provides evidence that ribonuclease protection assay on archival specimens would be highly valuable for retrospective studies, for diagnosis or prognosis...
  83. doi request reprint "Pseudo-bullous" Kaposi's sarcoma
    Daniele Torchia
    Eur J Dermatol 18:359-60. 2008
  84. ncbi request reprint Well-differentiated chondrosarcoma of the humerus with prominent granular cell component: a hitherto unreported occurrence
    Anna Cremonini
    Department of Pathology, University of Bologna, Bologna, Italy
    Int J Surg Pathol 14:147-54. 2006
    ..Although secondary granular cell changes have been described in a large variety of tumor types, this is, to the best of our knowledge, the first documentation of this phenomenon in a skeletal chondrosarcoma...