Claudio Franceschi

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE)
    C Franceschi
    Department of Experimental Pathology, University of Bologna
    Aging (Milano) 12:77-84. 2000
  2. ncbi Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Italy
    Exp Gerontol 34:911-21. 1999
  3. ncbi Inflamm-aging. An evolutionary perspective on immunosenescence
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Italy
    Ann N Y Acad Sci 908:244-54. 2000
  4. ncbi Neuroinflammation and the genetics of Alzheimer's disease: the search for a pro-inflammatory phenotype
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Italy
    Aging (Milano) 13:163-70. 2001
  5. pmc The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring
    Giuseppina Rose
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    BMC Genomics 8:293. 2007
  6. ncbi The genetics of human longevity
    Miriam Capri
    CIG Centro Interdipartimentale L Galvani, University of Bologna, Italy
    Ann N Y Acad Sci 1067:252-63. 2006
  7. ncbi p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1
    Stefano Salvioli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Cell Cycle 4:1264-71. 2005
  8. ncbi Immune system, cell senescence, aging and longevity--inflamm-aging reappraised
    Stefano Salvioli
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna Italy
    Curr Pharm Des 19:1675-9. 2013
  9. doi The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect
    Laura Invidia
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, Bologna, Italy
    Biogerontology 11:67-73. 2010
  10. pmc Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease
    Aurelia Santoro
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    PLoS ONE 5:e12037. 2010

Detail Information

Publications72

  1. ncbi Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE)
    C Franceschi
    Department of Experimental Pathology, University of Bologna
    Aging (Milano) 12:77-84. 2000
    ....
  2. ncbi Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Italy
    Exp Gerontol 34:911-21. 1999
    ..This perspective fits with basic assumptions of evolutionary theories of aging, such as antagonistic pleiotropy...
  3. ncbi Inflamm-aging. An evolutionary perspective on immunosenescence
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Italy
    Ann N Y Acad Sci 908:244-54. 2000
    ....
  4. ncbi Neuroinflammation and the genetics of Alzheimer's disease: the search for a pro-inflammatory phenotype
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Italy
    Aging (Milano) 13:163-70. 2001
    ..The possibility as well as the difficulty in identifying a pro-inflammatory phenotype, and its importance for the prevention, diagnosis and therapy of AD and other age-related pathologies are discussed...
  5. pmc The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring
    Giuseppina Rose
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    BMC Genomics 8:293. 2007
    ....
  6. ncbi The genetics of human longevity
    Miriam Capri
    CIG Centro Interdipartimentale L Galvani, University of Bologna, Italy
    Ann N Y Acad Sci 1067:252-63. 2006
    ..Thus, the genetics of human longevity appears to be quite peculiar in a context where antagonistic pleiotropy can play a major role and genes can have a different biological role at different ages...
  7. ncbi p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1
    Stefano Salvioli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Cell Cycle 4:1264-71. 2005
    ..We conclude that the functional difference between the two p53 codon 72 alleles exerts a broad impact on the capability of cell from aged people to respond to stressors such as cytotoxic drugs...
  8. ncbi Immune system, cell senescence, aging and longevity--inflamm-aging reappraised
    Stefano Salvioli
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna Italy
    Curr Pharm Des 19:1675-9. 2013
    ....
  9. doi The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect
    Laura Invidia
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, Bologna, Italy
    Biogerontology 11:67-73. 2010
    ..Such unusual age-related changes in the Klotho KL-VS genotype frequency is compatible with the hypothesis that alleles and genotypes involved in aging and longevity may exert their biological effect at specific time windows...
  10. pmc Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease
    Aurelia Santoro
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    PLoS ONE 5:e12037. 2010
    ....
  11. ncbi Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain
    Federico Licastro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Neurobiol Aging 24:921-6. 2003
    ..Both the -174 CC and VNTR DD genotypes were also associated with increased IL-6 levels in the blood and brain from AD. These findings suggest that IL-6 may play a multifaceted role in AD by affecting the turnover of the cytokine...
  12. ncbi Complexity of anti-immunosenescence strategies in humans
    Miriam Capri
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Artif Organs 30:730-42. 2006
    ....
  13. pmc Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population
    Michele Mishto
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    PLoS ONE 5:e9287. 2010
    ..Proteasome degradation is the key step in the production of MHC class I-restricted epitopes and therefore its activity could be an important element in the activation and regulation of autoreactive CD8+ T cells in Multiple Sclerosis...
  14. ncbi Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
    Clin Cancer Res 9:4860-4. 2003
    ....
  15. ncbi Age-dependent effects of in vitro radiofrequency exposure (mobile phone) on CD95+ T helper human lymphocytes
    Miriam Capri
    CIG, Interdepartmental Center L Galvani, University of Bologna, Italy
    Ann N Y Acad Sci 1067:493-9. 2006
    ..This age-related result is noteworthy given the importance of a such molecule in regulation of the immune response...
  16. ncbi Mitochondrial DNA involvement in human longevity
    Aurelia Santoro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Biochim Biophys Acta 1757:1388-99. 2006
    ..To test this hypothesis is one of the main challenge in the genetics of aging and longevity in the next future...
  17. ncbi The impact of mitochondrial DNA on human lifespan: a view from studies on centenarians
    Stefano Salvioli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Biotechnol J 3:740-9. 2008
    ....
  18. ncbi Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approach
    Stefano Salvioli
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Curr Pharm Des 14:226-36. 2008
    ..Since the "decisional process" that leads the cell to death is very complex, we will also discuss the possibility to address this topic with a systems biology approach...
  19. ncbi Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study
    Aurelia Santoro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, Bologna, Italy
    CNS Drugs 24:163-76. 2010
    ..g. health status and co-morbidities) associated with a complex disease such as AD in elderly people...
  20. ncbi What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
    Exp Gerontol 37:1263-71. 2002
    ....
  21. ncbi Colorectal cancer microenvironment: among nutrition, gut microbiota, inflammation and epigenetics
    Paolo Garagnani
    Department of Experimental Pathology, Alma Mater Studiorum, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Curr Pharm Des 19:765-78. 2013
    ..The synergic analysis of such parameters could provide new biological insights and effective biomarkers that could have applications in prevention, molecular diagnosis, prognosis and treatment of CRC...
  22. pmc Aging of the human metaorganism: the microbial counterpart
    Elena Biagi
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy
    Age (Dordr) 34:247-67. 2012
    ..The results of the few intervention trials reporting the use of pro/prebiotics in clinical conditions typical of the elderly will be critically reviewed...
  23. pmc TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells
    Serena Altilia
    Department of Experimental Pathology, University of Bologna, Bologna, 40126, Italy
    Aging (Albany NY) 4:28-39. 2012
    ....
  24. ncbi Human longevity within an evolutionary perspective: the peculiar paradigm of a post-reproductive genetics
    Miriam Capri
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, I 40126 Bologna, Italy
    Exp Gerontol 43:53-60. 2008
    ..6) The concomitant and integrated use of new in silico and high throughput strategies will greatly accelerate the identification of new longevity genes in humans...
  25. ncbi Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
    Claudio Franceschi
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Mech Ageing Dev 128:92-105. 2007
    ..We thus propose that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity...
  26. ncbi Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
    J Clin Endocrinol Metab 88:3299-304. 2003
    ....
  27. ncbi Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains
    Michele Mishto
    Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
    Neurobiol Aging 27:54-66. 2006
    ....
  28. ncbi A structural model of 20S immunoproteasomes: effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms
    Michele Mishto
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, I 40126 Bologna, Italy
    Biol Chem 387:417-29. 2006
    ....
  29. pmc The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms
    Paolo Garagnani
    Department of Experimental, Diagnostic and Specialty Medicine Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy Interdepartmental Centre L Galvani CIG, University of Bologna, Piazza di Porta S Donato 1, 40126 Bologna, Italy Center for Applied Biomedical Research, St Orsola Malpighi University Hospital, 40138 Bologna, Italy
    Biomed Res Int 2014:560340. 2014
    ....
  30. doi Ageing and gut microbes: perspectives for health maintenance and longevity
    Elena Biagi
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy
    Pharmacol Res 69:11-20. 2013
    ....
  31. ncbi Immunoproteasome in cancer and neuropathologies: a new therapeutic target?
    Elena Bellavista
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Curr Pharm Des 19:702-18. 2013
    ....
  32. doi Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged people
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, Italy
    Bioessays 34:40-9. 2012
    ..On the basis of this, we propose that inflamm-aging is a major contributor to the increase in cancer incidence and progression in aged people. Breast cancer will be presented as a paradigmatic example for this relationship...
  33. doi Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53
    Stefano Salvioli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Cancer Immunol Immunother 58:1909-17. 2009
    ..In particular they appear to be effectively protected from cancers. The mechanisms that underlie this protection are quite complex and still largely unclear...
  34. ncbi Complex patterns of gene expression in human T cells during in vivo aging
    Daniel Remondini
    Department of Physics, University of Bologna, Viale Berti Pichat 6 2, 40127 Bologna, Italy
    Mol Biosyst 6:1983-92. 2010
    ....
  35. ncbi mtDNA mutations in human aging and longevity: controversies and new perspectives opened by high-throughput technologies
    Federica Sevini
    Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy C I G Interdepartmental Centre L Galvani for Integrated Studies on Bioinformatics, Biophysics and Biocomplexity, University of Bologna, Via S Giacomo 12, 40126, Bologna, Italy Electronic address
    Exp Gerontol 56:234-44. 2014
    ..Finally, very recent findings in terms of mtDNA heteroplasmy (i.e. the coexistence of wild type and mutated copies of mtDNA) and aging as well as mitochondrial epigenetic mechanisms will also be discussed...
  36. doi HAPLOFIND: a new method for high-throughput mtDNA haplogroup assignment
    Dario Vianello
    Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna 40126, Italy
    Hum Mutat 34:1189-94. 2013
    ..HaploFind is freely accessible at the following Web address: https://haplofind.unibo.it. ..
  37. ncbi Present and future of anti-ageing epigenetic diets
    Maria Giulia Bacalini
    Department of Experimental, Diagnostic and Specialty Medicine DIMES, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy Interdepartmental Center L Galvani CIG, University of Bologna, Piazza di Porta San Donato 1, 40126 Bologna, Italy
    Mech Ageing Dev 136:101-15. 2014
    ....
  38. pmc Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians
    Elena Biagi
    Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy
    PLoS ONE 5:e10667. 2010
    ....
  39. doi Methylation of ELOVL2 gene as a new epigenetic marker of age
    Paolo Garagnani
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Aging Cell 11:1132-4. 2012
    ..Among the 3 genes, ELOVL2 shows a progressive increase in methylation that begins since the very first stage of life (Spearman's correlation coefficient = 0.92) and appears to be a very promising biomarker of aging...
  40. ncbi p66(Shc) gene has a pro-apoptotic role in human cell lines and it is activated by a p53-independent pathway
    Luca Tiberi
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Biochem Biophys Res Commun 342:503-8. 2006
    ..We confirm the importance of Serine 36 phosphorylation for p66(Shc) pro-apoptotic role, and our results suggest that the kinase involved in this process is activated independently from p53...
  41. doi Molecular remodeling of potassium channels in fibroblasts from centenarians: a marker of longevity?
    Isabella Zironi
    Department of Physics, University of Bologna, 40127 Bologna, Italy
    Mech Ageing Dev 131:674-81. 2010
    ..The maintenance of "young" K(+) currents and the peculiar age-related remodeling of K(+) channel subtypes in centenarian's DF is likely associated with successful aging and might provide a predictive marker of longevity...
  42. ncbi Genotype of inflammatory cytokines in limbal stem cell graft in Italian patients
    Francesco Lescai
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Biochem Biophys Res Commun 332:95-100. 2005
    ..A similar trend was evident in the 35 months of follow-up. Polymorphisms of IL-6 and TNF-alpha can be used to identify subgroups of patients with higher risk of unsuccessful outcome...
  43. ncbi 50 Hz sinusoidal magnetic fields do not affect human lymphocyte activation and proliferation in vitro
    Miriam Capri
    Department of Experimental Pathology, Via S Giacomo 12, University of Bologna, 40126 Bologna, Italy
    Phys Biol 1:211-9. 2004
    ..Thus, the conclusions are that two important functional phases of human lymphocytes, such as activation and proliferation, are not affected by exposures to 50 Hz magnetic fields similar to those found under power lines...
  44. ncbi Immunoproteasome in Macaca fascicularis: no age-dependent modification of abundance and activity in the brain and insight into an in silico structural model
    Elena Bellavista
    Interdepartmental Center for Studies on Biophysics, Bioinformatics and Biocomplexity L Galvani CIG, University of Bologna, Bologna, Italy
    Rejuvenation Res 11:73-82. 2008
    ..A comparison with humans suggests that in multiprotein complexes some functional subunits, such as alpha subunits, appear to be preferentially conserved during evolution...
  45. ncbi Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing
    Cristina Giuliani
    Department of Biological, Geological and Environmental Sciences, Laboratory of Molecular Anthropology and Centre for Genome Biology, University of Bologna, Bologna, Italy
    Aging (Albany NY) 6:454-67. 2014
    ..This familial profile suggests that heteroplasmy may contribute to familial longevity. ..
  46. ncbi Immunoproteasomes and immunosenescence
    Michele Mishto
    Department of Experimental Pathology, University of Bologna, Via San Giacomo, 12, Bologna IT 40126, Italy
    Ageing Res Rev 2:419-32. 2003
    ....
  47. pmc Charting the NF-κB pathway interactome map
    Paolo Tieri
    CIG Luigi Galvani Interdept Center, University of Bologna, Bologna, Italy
    PLoS ONE 7:e32678. 2012
    ..Moreover the interactome structure fits with the characteristics of a bow tie architecture. This interactome is intended as an open network resource available for further development, refinement and analysis...
  48. doi Modeling the in vitro 20S proteasome activity: the effect of PA28-alphabeta and of the sequence and length of polypeptides on the degradation kinetics
    Michele Mishto
    Interdepartmental Center for Studies on Biophysics, Bioinformatics and Biocomplexity L Galvani CIG, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    J Mol Biol 377:1607-17. 2008
    ..ProteaMAlg is publicly available on the web (http://www.proteamalg.com)...
  49. pmc Network, degeneracy and bow tie. Integrating paradigms and architectures to grasp the complexity of the immune system
    Paolo Tieri
    Interdept, Center Luigi Galvani for Bioinformatics, Biophysics and Biocomplexity CIG, University of Bologna, Via F, Selmi 3, 40126 Bologna, Italy
    Theor Biol Med Model 7:32. 2010
    ..e. the capacity to turn an apparently chaotic and highly dynamic set of signals into functional information...
  50. pmc The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas
    Maria Giulia Bacalini
    Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
    BMC Cancer 14:361. 2014
    ..In this study we analyzed the methylation profiles of the rDNA promoter and of the 5' regions of 18S and 28S in breast cancer...
  51. pmc Functional metagenomic profiling of intestinal microbiome in extreme ageing
    Simone Rampelli
    Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy
    Aging (Albany NY) 5:902-12. 2013
    ....
  52. doi Inflamm-ageing
    Elisa Cevenini
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Curr Opin Clin Nutr Metab Care 16:14-20. 2013
    ....
  53. ncbi Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians
    Massimiliano Bonafe
    Department of Experimental Pathology, Bologna University, Bologna, Italy
    Eur J Hum Genet 10:292-6. 2002
    ..In conclusion, we propose that genetic variability at PON1 locus affects survival at extreme advanced age...
  54. ncbi The MALVA (MAntova LongeVA) study: an investigation on people 98 years of age and over in a province of Northern Italy
    Paola Gueresi
    Department of Statistical Sciences Paolo Fortunati, University of Bologna, Via Belle Arti 41, Bologna, Italy
    Exp Gerontol 38:1189-97. 2003
    ..Data on the socio-demographic characteristics and the health status of very old people in the province of Mantova are discussed and compared to findings from previous studies on Italian centenarians...
  55. ncbi Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases
    Claudio Franceschi
    DIMES, Department of Experimental, Diagnostic and Specialty Medicine and CIG, Interdepartmental Center Luigi Galvani, University of Bologna, Italy IRCCS Institute of Neurological Sciences, and CNR ISOF, Bologna, Italy
    J Gerontol A Biol Sci Med Sci 69:S4-9. 2014
    ..This article reports the main outcomes of this session. ..
  56. ncbi The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific
    Nicola Raule
    BioPhysics and Biocomplexity and Department of Experimental Pathology, C I G Interdepartmental Centre L Galvani for Integrated Studies on Bioinformatics, University of Bologna, Bologna, 40126, Italy
    Aging Cell 13:401-7. 2014
    ....
  57. pmc Space/population and time/age in DNA methylation variability in humans: a study on IGF2/H19 locus in different Italian populations and in mono- and di-zygotic twins of different age
    Chiara Pirazzini
    CIG Interdipartimental Center L Galvani, University of Bologna, Italy
    Aging (Albany NY) 4:509-20. 2012
    ....
  58. ncbi Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging)
    Claudio Franceschi
    C I G Interdepartmental Centre L Galvani, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Ann N Y Acad Sci 1100:21-45. 2007
    ....
  59. ncbi Heat shock response by EBV-immortalized B-lymphocytes from centenarians and control subjects: a model to study the relevance of stress response in longevity
    Marina Marini
    Institute of Histology and General Embryology, University of Bologna, Via Belmerloro 8, Bologna 40126, Italy
    Exp Gerontol 39:83-90. 2004
    ..We found that cells from AA centenarian females displayed a lower synthesis of HSP70...
  60. ncbi Age-dependent changes in the susceptibility to apoptosis of peripheral blood CD4+ and CD8+ T lymphocytes with virgin or memory phenotype
    Stefano Salvioli
    Department of Experimental Pathology, Section of Immunology, University of Bologna, Bologna, Italy
    Mech Ageing Dev 124:409-18. 2003
    ..These results may also account, at least in part, for the deep remodelling of T cell repertoire that occurs during ageing...
  61. doi N-glycomic biomarkers of biological aging and longevity: a link with inflammaging
    Fabio Dall'olio
    Department of Experimental Pathology, University of Bologna, Via S Giacomo, 14 I 40126 Bologna, Italy
    Ageing Res Rev 12:685-98. 2013
    ..Thus, altered N-glycans are both powerful markers of aging and possible contributors to its pathogenesis...
  62. doi How to classify the oldest old according to their health status: a study on 1160 subjects belonging to 552 90+ Italian sib-ships characterized by familial longevity recruited within the GEHA EU Project
    Elisa Cevenini
    DIMES Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy C I G Interdepartmental Centre L Galvani, University of Bologna, Piazza di Porta San Donato 1, 40126 Bologna, Italy Electronic address
    Mech Ageing Dev 134:560-9. 2013
    ..This model showed that health status was correlated within sib-ships, suggesting a familial/genetic component. ..
  63. pmc Increased Plin2 expression in human skeletal muscle is associated with sarcopenia and muscle weakness
    Maria Conte
    Department of Experimental, Diagnostic and Specialty Medicine and Interdepartmental Centre L Galvani, CIG, University of Bologna, Bologna, Italy
    PLoS ONE 8:e73709. 2013
    ..The data also suggest that excessive intramuscular fat accumulation could be the initial trigger for p53 activation and consequent loss of muscle mass and strength. ..
  64. ncbi p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Biochem Biophys Res Commun 299:539-41. 2002
    ....
  65. ncbi Gene expression changes in human cells after exposure to mobile phone microwaves
    Daniel Remondini
    University of Bologna, Department of Physics, Bologna, Italy
    Proteomics 6:4745-54. 2006
    ..However, following microwave exposure, some but not all human cells might react with an increase in expression of genes encoding ribosomal proteins and therefore up-regulating the cellular metabolism...
  66. doi Integrating Omics data for signaling pathways, interactome reconstruction, and functional analysis
    Paolo Tieri
    L Galvani Interdept Center, University of Bologna, Bologna, Italy
    Methods Mol Biol 719:415-33. 2011
    ..We here describe a general workflow and relative hurdles in integrating online Omics data and analyzing reconstructed representations by using the available computational platforms...
  67. pmc Postoperative Delirium after elective and emergency surgery: analysis and checking of risk factors. A study protocol
    Vanni Agnoletti
    Department of Anaesthesiology, S Orsola Malpighi Hospital, University of Bologna, Italy
    BMC Surg 5:12. 2005
    ....
  68. ncbi In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potential
    Miriam Capri
    Department of Experimental Pathology, Section of Immunology, University of Bologna, Bologna, Italy
    Radiat Res 162:211-8. 2004
    ..When cells were exposed to a CW RF field, no significant modifications were observed in comparison with sham-exposed cells for all the end points investigated...
  69. ncbi Long-term effects of vaccination on attentional performance
    Roberto Nicoletti
    Department of Communication, University of Bologna, 40122 Bologna, Italy
    Vaccine 22:3877-81. 2004
    ....
  70. pmc Encoding the states of interacting proteins to facilitate biological pathways reconstruction
    Alberto Termanini
    L, Galvani Interdepartmental Center, University of Bologna, Bologna, Italy
    Biol Direct 5:52; discussion 52. 2010
    ..However, the information stored in electronic formats currently used doesn't allow a valid automatic reconstruction of biological pathways...
  71. ncbi An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
    Gene 286:121-6. 2002
    ....
  72. doi Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer
    Marco Candela
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Crit Rev Microbiol 37:1-14. 2011
    ..The integration of diet, microbial, and host factors in a system approach is mandatory to determine the overall balance of risk and protective factors for colorectal cancer onset...