Research Topics
Genomes and Genes | Claudio FranceschiSummaryAffiliation: University of Bologna Country: Italy Publications
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Publications
Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic loadC Franceschi
Department of Experimental Pathology, University of Bologna, Italy
Exp Gerontol 34:911-21. 1999..This perspective fits with basic assumptions of evolutionary theories of aging, such as antagonistic pleiotropy...- Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE)C Franceschi
Department of Experimental Pathology, University of Bologna
Aging (Milano) 12:77-84. 2000.... - Inflamm-aging. An evolutionary perspective on immunosenescenceC Franceschi
Department of Experimental Pathology, University of Bologna, Italy
Ann N Y Acad Sci 908:244-54. 2000.... - Neuroinflammation and the genetics of Alzheimer's disease: the search for a pro-inflammatory phenotypeC Franceschi
Department of Experimental Pathology, University of Bologna, Italy
Aging (Milano) 13:163-70. 2001..The possibility as well as the difficulty in identifying a pro-inflammatory phenotype, and its importance for the prevention, diagnosis and therapy of AD and other age-related pathologies are discussed... 
The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspringGiuseppina Rose
Department of Cell Biology, University of Calabria, 87036 Rende, Italy
BMC Genomics 8:293. 2007....- The genetics of human longevityMiriam Capri
CIG Centro Interdipartimentale L Galvani, University of Bologna, Italy
Ann N Y Acad Sci 1067:252-63. 2006..Thus, the genetics of human longevity appears to be quite peculiar in a context where antagonistic pleiotropy can play a major role and genes can have a different biological role at different ages... - p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1Stefano Salvioli
Department of Experimental Pathology, University of Bologna, Bologna, Italy
Cell Cycle 4:1264-71. 2005..We conclude that the functional difference between the two p53 codon 72 alleles exerts a broad impact on the capability of cell from aged people to respond to stressors such as cytotoxic drugs... 
The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effectLaura Invidia
Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, Bologna, Italy
Biogerontology 11:67-73. 2010..Such unusual age-related changes in the Klotho KL-VS genotype frequency is compatible with the hypothesis that alleles and genotypes involved in aging and longevity may exert their biological effect at specific time windows...- Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brainFederico Licastro
Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
Neurobiol Aging 24:921-6. 2003..Both the -174 CC and VNTR DD genotypes were also associated with increased IL-6 levels in the blood and brain from AD. These findings suggest that IL-6 may play a multifaceted role in AD by affecting the turnover of the cytokine... - Complexity of anti-immunosenescence strategies in humansMiriam Capri
Department of Experimental Pathology, University of Bologna, Bologna, Italy
Artif Organs 30:730-42. 2006.... - Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's diseaseAurelia Santoro
Department of Experimental Pathology, University of Bologna, Bologna, Italy
PLoS ONE 5:e12037. 2010.... - Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female populationMichele Mishto
Department of Experimental Pathology, University of Bologna, Bologna, Italy
PLoS ONE 5:e9287. 2010..Proteasome degradation is the key step in the production of MHC class I-restricted epitopes and therefore its activity could be an important element in the activation and regulation of autoreactive CD8+ T cells in Multiple Sclerosis... - Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patientsMassimiliano Bonafe
Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
Clin Cancer Res 9:4860-4. 2003.... - Age-dependent effects of in vitro radiofrequency exposure (mobile phone) on CD95+ T helper human lymphocytesMiriam Capri
CIG, Interdepartmental Center L Galvani, University of Bologna, Italy
Ann N Y Acad Sci 1067:493-9. 2006..This age-related result is noteworthy given the importance of a such molecule in regulation of the immune response... - Mitochondrial DNA involvement in human longevityAurelia Santoro
Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
Biochim Biophys Acta 1757:1388-99. 2006..To test this hypothesis is one of the main challenge in the genetics of aging and longevity in the next future... - The impact of mitochondrial DNA on human lifespan: a view from studies on centenariansStefano Salvioli
Department of Experimental Pathology, University of Bologna, Bologna, Italy
Biotechnol J 3:740-9. 2008.... - Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approachStefano Salvioli
Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
Curr Pharm Des 14:226-36. 2008..Since the "decisional process" that leads the cell to death is very complex, we will also discuss the possibility to address this topic with a systems biology approach... - What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenariansMassimiliano Bonafe
Department of Experimental Pathology, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
Exp Gerontol 37:1263-71. 2002.... - Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational studyAurelia Santoro
Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, Bologna, Italy
CNS Drugs 24:163-76. 2010..g. health status and co-morbidities) associated with a complex disease such as AD in elderly people... - TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cellsSerena Altilia
Department of Experimental Pathology, University of Bologna, Bologna, 40126, Italy
Aging (Albany NY) 4:28-39. 2012.... - Aging of the human metaorganism: the microbial counterpartElena Biagi
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy
Age (Dordr) 34:247-67. 2012..The results of the few intervention trials reporting the use of pro/prebiotics in clinical conditions typical of the elderly will be critically reviewed... - Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humansClaudio Franceschi
Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
Mech Ageing Dev 128:92-105. 2007..We thus propose that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity... - Human longevity within an evolutionary perspective: the peculiar paradigm of a post-reproductive geneticsMiriam Capri
Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, I 40126 Bologna, Italy
Exp Gerontol 43:53-60. 2008..6) The concomitant and integrated use of new in silico and high throughput strategies will greatly accelerate the identification of new longevity genes in humans... - A structural model of 20S immunoproteasomes: effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanismsMichele Mishto
Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, I 40126 Bologna, Italy
Biol Chem 387:417-29. 2006.... - Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brainsMichele Mishto
Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
Neurobiol Aging 27:54-66. 2006.... - Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span controlMassimiliano Bonafe
Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
J Clin Endocrinol Metab 88:3299-304. 2003.... - Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged peopleMassimiliano Bonafe
Department of Experimental Pathology, University of Bologna, Italy
Bioessays 34:40-9. 2012..On the basis of this, we propose that inflamm-aging is a major contributor to the increase in cancer incidence and progression in aged people. Breast cancer will be presented as a paradigmatic example for this relationship... - Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53Stefano Salvioli
Department of Experimental Pathology, University of Bologna, Bologna, Italy
Cancer Immunol Immunother 58:1909-17. 2009..In particular they appear to be effectively protected from cancers. The mechanisms that underlie this protection are quite complex and still largely unclear... - Complex patterns of gene expression in human T cells during in vivo agingDaniel Remondini
Department of Physics, University of Bologna, Viale Berti Pichat 6 2, 40127 Bologna, Italy
Mol Biosyst 6:1983-92. 2010.... - Molecular remodeling of potassium channels in fibroblasts from centenarians: a marker of longevity?Isabella Zironi
Department of Physics, University of Bologna, 40127 Bologna, Italy
Mech Ageing Dev 131:674-81. 2010..The maintenance of "young" K(+) currents and the peculiar age-related remodeling of K(+) channel subtypes in centenarian's DF is likely associated with successful aging and might provide a predictive marker of longevity... - Genotype of inflammatory cytokines in limbal stem cell graft in Italian patientsFrancesco Lescai
Department of Experimental Pathology, University of Bologna, Bologna, Italy
Biochem Biophys Res Commun 332:95-100. 2005..A similar trend was evident in the 35 months of follow-up. Polymorphisms of IL-6 and TNF-alpha can be used to identify subgroups of patients with higher risk of unsuccessful outcome... - 50 Hz sinusoidal magnetic fields do not affect human lymphocyte activation and proliferation in vitroMiriam Capri
Department of Experimental Pathology, Via S Giacomo 12, University of Bologna, 40126 Bologna, Italy
Phys Biol 1:211-9. 2004..Thus, the conclusions are that two important functional phases of human lymphocytes, such as activation and proliferation, are not affected by exposures to 50 Hz magnetic fields similar to those found under power lines... - p66(Shc) gene has a pro-apoptotic role in human cell lines and it is activated by a p53-independent pathwayLuca Tiberi
Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
Biochem Biophys Res Commun 342:503-8. 2006..We confirm the importance of Serine 36 phosphorylation for p66(Shc) pro-apoptotic role, and our results suggest that the kinase involved in this process is activated independently from p53... - Immunoproteasome in Macaca fascicularis: no age-dependent modification of abundance and activity in the brain and insight into an in silico structural modelElena Bellavista
Interdepartmental Center for Studies on Biophysics, Bioinformatics and Biocomplexity L Galvani CIG, University of Bologna, Bologna, Italy
Rejuvenation Res 11:73-82. 2008..A comparison with humans suggests that in multiprotein complexes some functional subunits, such as alpha subunits, appear to be preferentially conserved during evolution... - Charting the NF-κB pathway interactome mapPaolo Tieri
CIG Luigi Galvani Interdept Center, University of Bologna, Bologna, Italy
PLoS ONE 7:e32678. 2012..Moreover the interactome structure fits with the characteristics of a bow tie architecture. This interactome is intended as an open network resource available for further development, refinement and analysis... - Network, degeneracy and bow tie integrating paradigms and architectures to grasp the complexity of the immune systemPaolo Tieri
Interdept, Center Luigi Galvani for Bioinformatics, Biophysics and Biocomplexity CIG, University of Bologna, Via F, Selmi 3, 40126 Bologna, Italy
Theor Biol Med Model 7:32. 2010..e. the capacity to turn an apparently chaotic and highly dynamic set of signals into functional information... - Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenariansElena Biagi
Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy
PLoS ONE 5:e10667. 2010.... - Modeling the in vitro 20S proteasome activity: the effect of PA28-alphabeta and of the sequence and length of polypeptides on the degradation kineticsMichele Mishto
Interdepartmental Center for Studies on Biophysics, Bioinformatics and Biocomplexity L Galvani CIG, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
J Mol Biol 377:1607-17. 2008..ProteaMAlg is publicly available on the web (http://www.proteamalg.com)... - Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenariansMassimiliano Bonafe
Department of Experimental Pathology, Bologna University, Bologna, Italy
Eur J Hum Genet 10:292-6. 2002..In conclusion, we propose that genetic variability at PON1 locus affects survival at extreme advanced age... - Immunoproteasomes and immunosenescenceMichele Mishto
Department of Experimental Pathology, University of Bologna, Via San Giacomo, 12, Bologna IT-40126, Italy
Ageing Res Rev 2:419-32. 2003.... - The MALVA (MAntova LongeVA) study: an investigation on people 98 years of age and over in a province of Northern ItalyPaola Gueresi
Department of Statistical Sciences Paolo Fortunati, University of Bologna, Via Belle Arti 41, Bologna, Italy
Exp Gerontol 38:1189-97. 2003..Data on the socio-demographic characteristics and the health status of very old people in the province of Mantova are discussed and compared to findings from previous studies on Italian centenarians... - Immunoproteasome in cancer and neuropathologies: a new therapeutic target?Elena Bellavista
Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
Curr Pharm Des 19:702-18. 2013.... - Ageing and gut microbes: perspectives for health maintenance and longevityElena Biagi
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy
Pharmacol Res 69:11-20. 2013.... - Space/population and time/age in DNA methylation variability in humans: a study on IGF2/H19 locus in different Italian populations and in mono- and di-zygotic twins of different ageChiara Pirazzini
CIG Interdipartimental Center L Galvani, University of Bologna, Italy
Aging (Albany NY) 4:509-20. 2012.... - Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging)Claudio Franceschi
C I G Interdepartmental Centre L Galvani, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
Ann N Y Acad Sci 1100:21-45. 2007.... - Age-dependent changes in the susceptibility to apoptosis of peripheral blood CD4+ and CD8+ T lymphocytes with virgin or memory phenotypeStefano Salvioli
Department of Experimental Pathology, Section of Immunology, University of Bologna, Bologna, Italy
Mech Ageing Dev 124:409-18. 2003..These results may also account, at least in part, for the deep remodelling of T cell repertoire that occurs during ageing... - Heat shock response by EBV-immortalized B-lymphocytes from centenarians and control subjects: a model to study the relevance of stress response in longevityMarina Marini
Institute of Histology and General Embryology, University of Bologna, Via Belmerloro 8, Bologna 40126, Italy
Exp Gerontol 39:83-90. 2004..We found that cells from AA centenarian females displayed a lower synthesis of HSP70... - Methylation of ELOVL2 gene as a new epigenetic marker of agePaolo Garagnani
Department of Experimental Pathology, University of Bologna, Bologna, Italy
Aging Cell 11:1132-4. 2012..Among the 3 genes, ELOVL2 shows a progressive increase in methylation that begins since the very first stage of life (Spearman's correlation coefficient = 0.92) and appears to be a very promising biomarker of aging... - p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytesMassimiliano Bonafe
Department of Experimental Pathology, University of Bologna, Bologna, Italy
Biochem Biophys Res Commun 299:539-41. 2002.... - Integrating Omics data for signaling pathways, interactome reconstruction, and functional analysisPaolo Tieri
L Galvani Interdept Center, University of Bologna, Bologna, Italy
Methods Mol Biol 719:415-33. 2011..We here describe a general workflow and relative hurdles in integrating online Omics data and analyzing reconstructed representations by using the available computational platforms... - Gene expression changes in human cells after exposure to mobile phone microwavesDaniel Remondini
University of Bologna, Department of Physics, Bologna, Italy
Proteomics 6:4745-54. 2006..However, following microwave exposure, some but not all human cells might react with an increase in expression of genes encoding ribosomal proteins and therefore up-regulating the cellular metabolism... - Colorectal cancer microenvironment: among nutrition, gut microbiota, inflammation and epigeneticsPaolo Garagnani
Department of Experimental Pathology, Alma Mater Studiorum, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
Curr Pharm Des 19:765-78. 2013..The synergic analysis of such parameters could provide new biological insights and effective biomarkers that could have applications in prevention, molecular diagnosis, prognosis and treatment of CRC... - Postoperative Delirium after elective and emergency surgery: analysis and checking of risk factors. A study protocolVanni Agnoletti
Department of Anaesthesiology, S Orsola Malpighi Hospital, University of Bologna, Italy
BMC Surg 5:12. 2005..Moreover the presence of some relevant genetic polymorphisms will be studied in different genes such as IL-6, IL-10, TNF-alpha, and IL-1 cluster... - In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potentialMiriam Capri
Department of Experimental Pathology, Section of Immunology, University of Bologna, Bologna, Italy
Radiat Res 162:211-8. 2004..When cells were exposed to a CW RF field, no significant modifications were observed in comparison with sham-exposed cells for all the end points investigated... - Long-term effects of vaccination on attentional performanceRoberto Nicoletti
Department of Communication, University of Bologna, 40122 Bologna, Italy
Vaccine 22:3877-81. 2004.... - Encoding the states of interacting proteins to facilitate biological pathways reconstructionAlberto Termanini
L, Galvani Interdepartmental Center, University of Bologna, Bologna, Italy
Biol Direct 5:52; discussion 52. 2010..However, the information stored in electronic formats currently used doesn't allow a valid automatic reconstruction of biological pathways... - Inflamm-ageingElisa Cevenini
Department of Experimental Pathology, University of Bologna, Bologna, Italy
Curr Opin Clin Nutr Metab Care 16:14-20. 2013.... - Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancerMarco Candela
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
Crit Rev Microbiol 37:1-14. 2011..The integration of diet, microbial, and host factors in a system approach is mandatory to determine the overall balance of risk and protective factors for colorectal cancer onset... - An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevityMassimiliano Bonafe
Department of Experimental Pathology, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
Gene 286:121-6. 2002....