C Franceschi

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Immune system, cell senescence, aging and longevity - inflamm-aging reappraised
    Stefano Salvioli
    Dept Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna I
    Curr Pharm Des 19:1675-9. 2013
  2. ncbi Network, degeneracy and bow tie integrating paradigms and architectures to grasp the complexity of the immune system
    Paolo Tieri
    Interdept, Center Luigi Galvani for Bioinformatics, Biophysics and Biocomplexity CIG, University of Bologna, Via F, Selmi 3, 40126 Bologna, Italy
    Theor Biol Med Model 7:32. 2010
  3. ncbi Encoding the states of interacting proteins to facilitate biological pathways reconstruction
    Alberto Termanini
    L, Galvani Interdepartmental Center, University of Bologna, Bologna, Italy
    Biol Direct 5:52; discussion 52. 2010
  4. ncbi Application of Wavelet Packet Transform to detect genetic polymorphisms by the analysis of inter-Alu PCR patterns
    Maurizio Cardelli
    Italian National Research Centers on Aging I N R C A, Ancona, Italy
    BMC Bioinformatics 11:593. 2010
  5. ncbi Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation
    Nicola Neretti
    Institute for Brain and Neural Systems, Brown University, Providence RI, USA
    BMC Bioinformatics 8:S16. 2007
  6. ncbi Quantifying the relevance of different mediators in the human immune cell network
    P Tieri
    Dipartimento di Patologia Sperimentale, , Via San Giacomo 12, 40126 Bologna, Italy
    Bioinformatics 21:1639-43. 2005
  7. ncbi Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
    Claudio Franceschi
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Mech Ageing Dev 128:92-105. 2007
  8. ncbi Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging)
    Claudio Franceschi
    C I G Interdepartmental Centre L Galvani, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Ann N Y Acad Sci 1100:21-45. 2007
  9. ncbi Inflammaging as a major characteristic of old people: can it be prevented or cured?
    Claudio Franceschi
    Department of Experimental Pathology and Interdepartmental Centre L Galvani at the University of Bologna, Bologna, Italy
    Nutr Rev 65:S173-6. 2007
  10. ncbi Genes, ageing and longevity in humans: problems, advantages and perspectives
    S Salvioli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Free Radic Res 40:1303-23. 2006

Detail Information

Publications118 found, 100 shown here

  1. ncbi Immune system, cell senescence, aging and longevity - inflamm-aging reappraised
    Stefano Salvioli
    Dept Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna I
    Curr Pharm Des 19:1675-9. 2013
    ....
  2. ncbi Network, degeneracy and bow tie integrating paradigms and architectures to grasp the complexity of the immune system
    Paolo Tieri
    Interdept, Center Luigi Galvani for Bioinformatics, Biophysics and Biocomplexity CIG, University of Bologna, Via F, Selmi 3, 40126 Bologna, Italy
    Theor Biol Med Model 7:32. 2010
    ..e. the capacity to turn an apparently chaotic and highly dynamic set of signals into functional information...
  3. ncbi Encoding the states of interacting proteins to facilitate biological pathways reconstruction
    Alberto Termanini
    L, Galvani Interdepartmental Center, University of Bologna, Bologna, Italy
    Biol Direct 5:52; discussion 52. 2010
    ..However, the information stored in electronic formats currently used doesn't allow a valid automatic reconstruction of biological pathways...
  4. ncbi Application of Wavelet Packet Transform to detect genetic polymorphisms by the analysis of inter-Alu PCR patterns
    Maurizio Cardelli
    Italian National Research Centers on Aging I N R C A, Ancona, Italy
    BMC Bioinformatics 11:593. 2010
    ..Our goal is to automatically detect regions in the inter-Alu pattern likely associated to the presence of genetic polymorphisms...
  5. ncbi Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation
    Nicola Neretti
    Institute for Brain and Neural Systems, Brown University, Providence RI, USA
    BMC Bioinformatics 8:S16. 2007
    ....
  6. ncbi Quantifying the relevance of different mediators in the human immune cell network
    P Tieri
    Dipartimento di Patologia Sperimentale, , Via San Giacomo 12, 40126 Bologna, Italy
    Bioinformatics 21:1639-43. 2005
    ..contact: ...
  7. ncbi Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
    Claudio Franceschi
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Mech Ageing Dev 128:92-105. 2007
    ..We thus propose that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity...
  8. ncbi Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging)
    Claudio Franceschi
    C I G Interdepartmental Centre L Galvani, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Ann N Y Acad Sci 1100:21-45. 2007
    ....
  9. ncbi Inflammaging as a major characteristic of old people: can it be prevented or cured?
    Claudio Franceschi
    Department of Experimental Pathology and Interdepartmental Centre L Galvani at the University of Bologna, Bologna, Italy
    Nutr Rev 65:S173-6. 2007
    ..The key to successful aging and longevity is to decrease chronic inflammation without compromising an acute response when exposed to pathogens...
  10. ncbi Genes, ageing and longevity in humans: problems, advantages and perspectives
    S Salvioli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Free Radic Res 40:1303-23. 2006
    ....
  11. ncbi Systems biology and longevity: an emerging approach to identify innovative anti-aging targets and strategies
    E Cevenini
    CIG Interdepartmental Centre L Galvani, University of Bologna, Bologna, Italy
    Curr Pharm Des 16:802-13. 2010
    ....
  12. ncbi Inflamm-aging. An evolutionary perspective on immunosenescence
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Italy
    Ann N Y Acad Sci 908:244-54. 2000
    ....
  13. ncbi Neuroinflammation and the genetics of Alzheimer's disease: the search for a pro-inflammatory phenotype
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Italy
    Aging (Milano) 13:163-70. 2001
    ..The possibility as well as the difficulty in identifying a pro-inflammatory phenotype, and its importance for the prevention, diagnosis and therapy of AD and other age-related pathologies are discussed...
  14. ncbi Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology
    S Salvioli
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, Bologna, Italy
    Curr Pharm Des 12:3161-71. 2006
    ..New perspectives for future studies, including phylogenetic studies in animal models and in silico studies on mathematical and bioinformatic models inspired by the systems biology approach, are also proposed...
  15. ncbi The genetics of human longevity
    Miriam Capri
    CIG Centro Interdipartimentale L Galvani, University of Bologna, Italy
    Ann N Y Acad Sci 1067:252-63. 2006
    ..Thus, the genetics of human longevity appears to be quite peculiar in a context where antagonistic pleiotropy can play a major role and genes can have a different biological role at different ages...
  16. ncbi Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Italy
    Exp Gerontol 34:911-21. 1999
    ..This perspective fits with basic assumptions of evolutionary theories of aging, such as antagonistic pleiotropy...
  17. ncbi A stochastic model for CD8(+)T cell dynamics in human immunosenescence: implications for survival and longevity
    F Luciani
    Department of Physics, University of Bologna, Bologna, Italy
    J Theor Biol 213:587-97. 2001
    ..Furthermore, the stochastic process results in being responsible for the peculiar shape of the survival curves...
  18. ncbi A mathematical model for the immunosenescence
    F Luciani
    Dipartimento di Fisica, , Via Irnerio 46, 40126 Bologna
    Riv Biol 94:305-18. 2001
    ..Starting from the hypothesis that the depletion of virgin cells with cytotoxic properties (CD8+) is a mortality marker, the model provides survival curves quite similar to the demographic curves...
  19. ncbi The network and the remodeling theories of aging: historical background and new perspectives
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Exp Gerontol 35:879-96. 2000
    ....
  20. ncbi p66(shc) is highly expressed in fibroblasts from centenarians
    S Pandolfi
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Mech Ageing Dev 126:839-44. 2005
    ..Thus, cells from centenarians present a peculiar regulation of p66(shc), suggesting that its role in mammalian longevity is more complex than previously thought...
  21. ncbi An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
    Gene 286:121-6. 2002
    ....
  22. ncbi A cytofluorimetric study of T lymphocyte subsets in rat lymphoid tissues (thymus, lymph nodes) and peripheral blood: a continuous remodelling during the first year of life
    M Capri
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Exp Gerontol 35:613-25. 2000
    ....
  23. ncbi Mitochondria, aging and longevity--a new perspective
    S Salvioli
    Department of Experimental Pathology, University of Bologna, Italy
    FEBS Lett 492:9-13. 2001
    ..We surmise that an integration of signals in multimolecular complexes occurs at mitochondrial level. These phenomena can be of critical importance for human aging and longevity...
  24. ncbi The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect
    Laura Invidia
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, Bologna, Italy
    Biogerontology 11:67-73. 2010
    ..Such unusual age-related changes in the Klotho KL-VS genotype frequency is compatible with the hypothesis that alleles and genotypes involved in aging and longevity may exert their biological effect at specific time windows...
  25. ncbi Human models of aging and longevity
    E Cevenini
    University of Bologna, Department of Experimental Pathology, Via S Giacomo 12, 40126 Bologna, Italy
    Expert Opin Biol Ther 8:1393-405. 2008
    ..Therefore, each old person must be considered as a singleton, and consequently the definition of 'aging phenotype' is very difficult...
  26. ncbi Effect of zinc ions on apoptosis in PBMCs from healthy aged subjects
    R Ostan
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Biogerontology 7:437-47. 2006
    ....
  27. ncbi Increase of homozygosity in centenarians revealed by a new inter-Alu PCR technique
    M BonaFe
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Exp Gerontol 36:1063-73. 2001
    ..This novel inter-Alu PCR approach could represent a valuable tool to identify longevity-associated DNA sequences interspersed throughout human genome, without making any a priori assumption about their nature and function...
  28. ncbi What studies on human longevity tell us about the risk for cancer in the oldest old: data and hypotheses on the genetics and immunology of centenarians
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
    Exp Gerontol 37:1263-71. 2002
    ....
  29. ncbi Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians
    Massimiliano Bonafe
    Department of Experimental Pathology, Bologna University, Bologna, Italy
    Eur J Hum Genet 10:292-6. 2002
    ..In conclusion, we propose that genetic variability at PON1 locus affects survival at extreme advanced age...
  30. ncbi Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE)
    C Franceschi
    Department of Experimental Pathology, University of Bologna
    Aging (Milano) 12:77-84. 2000
    ....
  31. ncbi The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death
    M BonaFe
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Cell Death Differ 11:962-73. 2004
    ....
  32. ncbi The unexpected contribution of immunosenescence to the leveling off of cancer incidence and mortality in the oldest old
    M BonaFe
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 12, 40126, Bologna, Italy
    Crit Rev Oncol Hematol 39:227-33. 2001
    ..In this perspective, studies on immunosenescence likely provide insights on mechanisms responsible for the individual capacity to escape from the life-threatening consequences of cancer outgrowth...
  33. ncbi A gender--dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity
    M BonaFe
    Department of Experimental Pathology, Bologna University, Bologna, Italy
    Eur J Immunol 31:2357-61. 2001
    ..On the whole, our data suggest that those individuals who are genetically predisposed to produce high levels of IL-6 during aging, i.e. -174 locus GG homozygous men, are disadvantaged for longevity...
  34. ncbi Age-dependent changes in the susceptibility to apoptosis of peripheral blood CD4+ and CD8+ T lymphocytes with virgin or memory phenotype
    Stefano Salvioli
    Department of Experimental Pathology, Section of Immunology, University of Bologna, Bologna, Italy
    Mech Ageing Dev 124:409-18. 2003
    ..These results may also account, at least in part, for the deep remodelling of T cell repertoire that occurs during ageing...
  35. ncbi Immunoproteasome LMP2 60HH variant alters MBP epitope generation and reduces the risk to develop multiple sclerosis in Italian female population
    Michele Mishto
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    PLoS ONE 5:e9287. 2010
    ..Proteasome degradation is the key step in the production of MHC class I-restricted epitopes and therefore its activity could be an important element in the activation and regulation of autoreactive CD8+ T cells in Multiple Sclerosis...
  36. ncbi Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
    J Clin Endocrinol Metab 88:3299-304. 2003
    ....
  37. ncbi Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches
    E Cevenini
    Department of Experimental Pathology, University of Bologna, Italy
    Curr Pharm Des 16:609-18. 2010
    ..Moreover, some of the possible strategies and therapies to counteract the different sources of molecular mediators which lead to the age-related inflammatory phenotype will be presented...
  38. ncbi Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
    C Franceschi
    Department of Gerontological Research, Italian National Research Center on Aging INRCA, Ancona, Italy
    Vaccine 18:1717-20. 2000
    ....
  39. ncbi Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment
    G Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti 9, 40138 Bologna, Italy
    Mech Ageing Dev 121:251-61. 2000
    ..Previous reports have shown elevated plasma total homocysteine (tHcy) levels in elderly person with impaired cognition...
  40. ncbi Association studies on human mitochondrial DNA: methodological aspects and results in the most common age-related diseases
    Nicola Raule
    Centro Interdipartimentale L Galvani, Via S Giacomo 12, 40126 Bologna, Italy
    Mitochondrion 7:29-38. 2007
    ....
  41. ncbi p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1
    Stefano Salvioli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Cell Cycle 4:1264-71. 2005
    ..We conclude that the functional difference between the two p53 codon 72 alleles exerts a broad impact on the capability of cell from aged people to respond to stressors such as cytotoxic drugs...
  42. ncbi Immunoproteasome in Macaca fascicularis: no age-dependent modification of abundance and activity in the brain and insight into an in silico structural model
    Elena Bellavista
    Interdepartmental Center for Studies on Biophysics, Bioinformatics and Biocomplexity L Galvani CIG, University of Bologna, Bologna, Italy
    Rejuvenation Res 11:73-82. 2008
    ..A comparison with humans suggests that in multiprotein complexes some functional subunits, such as alpha subunits, appear to be preferentially conserved during evolution...
  43. ncbi Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains
    Michele Mishto
    Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
    Neurobiol Aging 27:54-66. 2006
    ....
  44. ncbi A structural model of 20S immunoproteasomes: effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms
    Michele Mishto
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, I 40126 Bologna, Italy
    Biol Chem 387:417-29. 2006
    ....
  45. ncbi Age-dependent effects of in vitro radiofrequency exposure (mobile phone) on CD95+ T helper human lymphocytes
    Miriam Capri
    CIG, Interdepartmental Center L Galvani, University of Bologna, Italy
    Ann N Y Acad Sci 1067:493-9. 2006
    ..This age-related result is noteworthy given the importance of a such molecule in regulation of the immune response...
  46. ncbi Modeling the in vitro 20S proteasome activity: the effect of PA28-alphabeta and of the sequence and length of polypeptides on the degradation kinetics
    Michele Mishto
    Interdepartmental Center for Studies on Biophysics, Bioinformatics and Biocomplexity L Galvani CIG, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    J Mol Biol 377:1607-17. 2008
    ..ProteaMAlg is publicly available on the web (http://www.proteamalg.com)...
  47. ncbi Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer
    Marco Candela
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Crit Rev Microbiol 37:1-14. 2011
    ..The integration of diet, microbial, and host factors in a system approach is mandatory to determine the overall balance of risk and protective factors for colorectal cancer onset...
  48. ncbi Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease
    Aurelia Santoro
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    PLoS ONE 5:e12037. 2010
    ....
  49. ncbi Complex patterns of gene expression in human T cells during in vivo aging
    Daniel Remondini
    Department of Physics, University of Bologna, Viale Berti Pichat 6 2, 40127 Bologna, Italy
    Mol Biosyst 6:1983-92. 2010
    ....
  50. ncbi Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians
    Elena Biagi
    Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy
    PLoS ONE 5:e10667. 2010
    ....
  51. ncbi Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study
    Aurelia Santoro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, Bologna, Italy
    CNS Drugs 24:163-76. 2010
    ..g. health status and co-morbidities) associated with a complex disease such as AD in elderly people...
  52. ncbi PON1 is a longevity gene: results of a meta-analysis
    Francesco Lescai
    CIG Centre L Galvani for Biophysics, Bioinformatics and Biocomplexity, Alma Mater Studiorum Universita di Bologna, Bologna, Italy
    Ageing Res Rev 8:277-84. 2009
    ..These results likely represent the counterpart of the effects observed on cardiovascular diseases (CVD), as centenarians and nonagenarians escaped or delayed the onset of the major age-related diseases, including CVD...
  53. ncbi Human longevity and 11p15.5: a study in 1321 centenarians
    Francesco Lescai
    Centro Interdipartimentale L Galvani per Studi Integrati di Bioinformatica, Biofisica e Biocomplessità Alma Mater Studiorum Università di Bologna, Italy
    Eur J Hum Genet 17:1515-9. 2009
    ....
  54. ncbi Role of mitochondrial DNA in longevity, aging and age-related diseases in humans: a reappraisal
    Federica Sevini
    Interdepartmental Center for Studies on Biophysics, Bioinformatics and Biocomplexity L Galvani CIG, Bologna, Italy
    Ital J Biochem 56:243-53. 2007
    ....
  55. ncbi Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53
    Stefano Salvioli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Cancer Immunol Immunother 58:1909-17. 2009
    ..In particular they appear to be effectively protected from cancers. The mechanisms that underlie this protection are quite complex and still largely unclear...
  56. ncbi Integrating Omics data for signaling pathways, interactome reconstruction, and functional analysis
    Paolo Tieri
    L Galvani Interdept Center, University of Bologna, Bologna, Italy
    Methods Mol Biol 719:415-33. 2011
    ..We here describe a general workflow and relative hurdles in integrating online Omics data and analyzing reconstructed representations by using the available computational platforms...
  57. ncbi Genotype of inflammatory cytokines in limbal stem cell graft in Italian patients
    Francesco Lescai
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Biochem Biophys Res Commun 332:95-100. 2005
    ..A similar trend was evident in the 35 months of follow-up. Polymorphisms of IL-6 and TNF-alpha can be used to identify subgroups of patients with higher risk of unsuccessful outcome...
  58. ncbi The MALVA (MAntova LongeVA) study: an investigation on people 98 years of age and over in a province of Northern Italy
    Paola Gueresi
    Department of Statistical Sciences Paolo Fortunati, University of Bologna, Via Belle Arti 41, Bologna, Italy
    Exp Gerontol 38:1189-97. 2003
    ..Data on the socio-demographic characteristics and the health status of very old people in the province of Mantova are discussed and compared to findings from previous studies on Italian centenarians...
  59. ncbi Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain
    Federico Licastro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Neurobiol Aging 24:921-6. 2003
    ..Both the -174 CC and VNTR DD genotypes were also associated with increased IL-6 levels in the blood and brain from AD. These findings suggest that IL-6 may play a multifaceted role in AD by affecting the turnover of the cytokine...
  60. ncbi Retention of the p53 codon 72 arginine allele is associated with a reduction of disease-free and overall survival in arginine/proline heterozygous breast cancer patients
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, 40126 Bologna, Italy
    Clin Cancer Res 9:4860-4. 2003
    ....
  61. ncbi Heat shock response by EBV-immortalized B-lymphocytes from centenarians and control subjects: a model to study the relevance of stress response in longevity
    Marina Marini
    Institute of Histology and General Embryology, University of Bologna, Via Belmerloro 8, Bologna 40126, Italy
    Exp Gerontol 39:83-90. 2004
    ..We found that cells from AA centenarian females displayed a lower synthesis of HSP70...
  62. ncbi Immunoproteasomes and immunosenescence
    Michele Mishto
    Department of Experimental Pathology, University of Bologna, Via San Giacomo, 12, Bologna IT-40126, Italy
    Ageing Res Rev 2:419-32. 2003
    ....
  63. ncbi In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potential
    Miriam Capri
    Department of Experimental Pathology, Section of Immunology, University of Bologna, Bologna, Italy
    Radiat Res 162:211-8. 2004
    ..When cells were exposed to a CW RF field, no significant modifications were observed in comparison with sham-exposed cells for all the end points investigated...
  64. ncbi Long-term effects of vaccination on attentional performance
    Roberto Nicoletti
    Department of Communication, University of Bologna, 40122 Bologna, Italy
    Vaccine 22:3877-81. 2004
    ....
  65. ncbi Centenarians as a model for healthy aging
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Biochem Soc Trans 31:457-61. 2003
    ....
  66. ncbi Human longevity within an evolutionary perspective: the peculiar paradigm of a post-reproductive genetics
    Miriam Capri
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, I 40126 Bologna, Italy
    Exp Gerontol 43:53-60. 2008
    ..6) The concomitant and integrated use of new in silico and high throughput strategies will greatly accelerate the identification of new longevity genes in humans...
  67. ncbi Mitochondrial DNA involvement in human longevity
    Aurelia Santoro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Biochim Biophys Acta 1757:1388-99. 2006
    ..To test this hypothesis is one of the main challenge in the genetics of aging and longevity in the next future...
  68. ncbi p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes
    Massimiliano Bonafe
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Biochem Biophys Res Commun 299:539-41. 2002
    ....
  69. ncbi Apoptosis-resistant phenotype in HL-60-derived cells HCW-2 is related to changes in expression of stress-induced proteins that impact on redox status and mitochondrial metabolism
    S Salvioli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Cell Death Differ 10:163-74. 2003
    ..These observations could have some implications for the therapy of cancer, and for the design of combined strategies that act on antioxidant defences of the neoplastic cell...
  70. ncbi Chronic antigenic stress, immunosenescence and human survivorship over the 3 last centuries: heuristic value of a mathematical model
    L Mariani
    Department of Physics, Via Irnerio 46, 40126, Bologna, Italy
    Mech Ageing Dev 124:453-8. 2003
    ....
  71. ncbi 1800 MHz radiofrequency (mobile phones, different Global System for Mobile communication modulations) does not affect apoptosis and heat shock protein 70 level in peripheral blood mononuclear cells from young and old donors
    M Capri
    Department of Experimental Pathology, Section of Immunology, CIG Centro Interdipartimentale L Galvani, Via S Giacomo 12, University of Bologna, Italy
    Int J Radiat Biol 80:389-97. 2004
    ....
  72. ncbi Metabolic age modelling: the lesson from centenarians
    G Paolisso
    II University of Naples, Naples, Italy, University of Bologna, Bologna, Italy
    Eur J Clin Invest 30:888-94. 2000
    ..In order to design the clinical picture of such successful ageing, anthropometric, endocrine and metabolic characteristics of healthy centenarians (HC), compared with aged subject, have been outlined...
  73. ncbi Complexity of anti-immunosenescence strategies in humans
    Miriam Capri
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Artif Organs 30:730-42. 2006
    ....
  74. ncbi Role of connectivity in immune and neural network models: memory development and aging
    Daniel Remondini
    Dipartimento di Fisica, , Via Berti Pichat 6, 40127 Bologna, Italy
    Riv Biol 96:225-39. 2003
    ..Moreover, changes in connectivity may lead to changes in memory properties during development and aging...
  75. ncbi p66(Shc) gene has a pro-apoptotic role in human cell lines and it is activated by a p53-independent pathway
    Luca Tiberi
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Biochem Biophys Res Commun 342:503-8. 2006
    ..We confirm the importance of Serine 36 phosphorylation for p66(Shc) pro-apoptotic role, and our results suggest that the kinase involved in this process is activated independently from p53...
  76. ncbi The impact of mitochondrial DNA on human lifespan: a view from studies on centenarians
    Stefano Salvioli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Biotechnol J 3:740-9. 2008
    ....
  77. ncbi 50 Hz sinusoidal magnetic fields do not affect human lymphocyte activation and proliferation in vitro
    Miriam Capri
    Department of Experimental Pathology, Via S Giacomo 12, University of Bologna, 40126 Bologna, Italy
    Phys Biol 1:211-9. 2004
    ..Thus, the conclusions are that two important functional phases of human lymphocytes, such as activation and proliferation, are not affected by exposures to 50 Hz magnetic fields similar to those found under power lines...
  78. ncbi Different types of cell death in organismal aging and longevity: state of the art and possible systems biology approach
    Stefano Salvioli
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Curr Pharm Des 14:226-36. 2008
    ..Since the "decisional process" that leads the cell to death is very complex, we will also discuss the possibility to address this topic with a systems biology approach...
  79. ncbi Mismatch repair system and aging: microsatellite instability in peripheral blood cells from differently aged participants
    Simona Neri
    Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, IOR, Bologna, Italy
    J Gerontol A Biol Sci Med Sci 60:285-92. 2005
    ....
  80. ncbi Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells
    M Mishto
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy
    Exp Gerontol 37:301-8. 2002
    ..No correlation with TNFalpha-induced apoptosis and no difference in frequency between young people and nonagenarians/centenarians was observed when the LMP7 nucleotide 145 polymorphism was studied...
  81. ncbi Postoperative Delirium after elective and emergency surgery: analysis and checking of risk factors. A study protocol
    Vanni Agnoletti
    Department of Anaesthesiology, S Orsola Malpighi Hospital, University of Bologna, Italy
    BMC Surg 5:12. 2005
    ..Moreover the presence of some relevant genetic polymorphisms will be studied in different genes such as IL-6, IL-10, TNF-alpha, and IL-1 cluster...
  82. ncbi Structural characterization of p53 isoforms due to the polymorphism at codon 72 by mass spectrometry and circular dichroism
    Marina Naldi
    Department of Pharmaceutical Sciences, Via Belmeloro 6, 40126 Bologna, Italy
    J Pharm Biomed Anal 53:200-6. 2010
    ..Furthermore, these studies establish a mass spectrometry method to identify the two isoforms that can be useful for future interactome studies and cancer drug discovery...
  83. ncbi Gene expression changes in human cells after exposure to mobile phone microwaves
    Daniel Remondini
    University of Bologna, Department of Physics, Bologna, Italy
    Proteomics 6:4745-54. 2006
    ..However, following microwave exposure, some but not all human cells might react with an increase in expression of genes encoding ribosomal proteins and therefore up-regulating the cellular metabolism...
  84. ncbi Analysis of HLA-DRB1, DQA1, DQB1 haplotypes in Sardinian centenarians
    Letizia Scola
    Gruppo di Studio dell Immunosenescenza, Dipartimento di Biopatologia e Metodologie, Biomediche, Universita di Palermo, Palermo, Italy
    Exp Gerontol 43:114-8. 2008
    ..These data suggest that these haplotypes might have a role in determining life span expectancy and longevity...
  85. ncbi A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism
    Maurizio Cardelli
    Department of Gerontological Research, Italian National Research Center on Aging, Ancona, Italy
    J Gerontol A Biol Sci Med Sci 63:454-60. 2008
    ..A haplotype analysis carried out in men by screening the TNFa, TNFc, and TNFe microsatellite polymorphisms (spanning about 20 kb) confirmed the association of the TNF region with life expectancy...
  86. ncbi Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply
    Eugenio Mocchegiani
    Immunology Center Section Nutrition, Immunity and Ageing, Research Department Italian National Research Centres on Ageing INRCA, Via Birarelli 8, 60121, Ancona, Italy
    Mech Ageing Dev 124:459-68. 2003
    ..Therefore, the zinc ion bioavailability by zinc-bound MTs homeostasis is pivotal to reach health longevity and successful ageing...
  87. ncbi Association between the HFE mutations and unsuccessful ageing: a study in Alzheimer's disease patients from Northern Italy
    Giuseppina Candore
    Gruppo di Studio sull Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, 90134, Palermo, Italy
    Mech Ageing Dev 124:525-8. 2003
    ..Thus, our study does not support the suggestion that H63D mutations may anticipate sporadic AD clinical presentation in susceptible individuals...
  88. ncbi Association between the HFE mutations and longevity: a study in Sardinian population
    Ciriaco Carru
    AKEA Project, Cattedra di Biochimica Clinica, Universita di Sassari, Viale S Pietro 43 B, Sassari, Italy
    Mech Ageing Dev 124:529-32. 2003
    ..11%, i.e. 30/136 vs. 23/210, P=0.008. These findings are consistent with the hypothesis that there may be a survival difference for centenarian women, among carriers and non-carriers of alleles involved in iron sparing...
  89. ncbi A novel mitochondrial DNA-like sequence insertion polymorphism in Intron I of the FOXO1A gene
    Claudia Giampieri
    Department of Research and Diabetology Unit, Italian National Research Centers on Ageing, Via Birarelli 8, Ancona 60124, Italy
    Gene 327:215-9. 2004
    ..Hence, FOXO1A Intron I is a polymorphic nuclear region involved in the exchange of DNA material between mitochondrial and genomic DNA, which is a well-established mechanism of evolutionary change in eukaryotes...
  90. ncbi The role of IL-1 gene cluster in longevity: a study in Italian population
    Luca Cavallone
    Direzione Scientifica, Italian National Research Center on Aging, Villa Gusso, Via S Margherita, n 5 60121, Ancona, Italy
    Mech Ageing Dev 124:533-8. 2003
    ....
  91. ncbi In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging
    Fabiola Olivieri
    Italian National Research Centers on Aging (I.N.R.C.A, Via S. Margherita, n. 5, 60121, Ancona, Italy
    Mech Ageing Dev 124:549-53. 2003
    ..Thus, the EBV-immortalized B lymphocytes can be considered a useful in vitro model for studying the genetic control of IL-6 production and its changes with age...
  92. ncbi Role of polymorphisms of CC-chemokine receptor-5 gene in acute myocardial infarction and biological implications for longevity
    Carmela Rita Balistreri
    Haematologica 93:637-8. 2008
  93. ncbi Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence
    Franco Zanni
    Dipartimento di Medicina Interna e Scienze Biomediche, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    Exp Gerontol 38:981-7. 2003
    ....
  94. ncbi The -174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing
    Robertina Giacconi
    Immunology Centre Sect Nutrition, Immunity and Ageing, Research Department of INRCA, Via Birarelli 8, 60121 Ancona, Italy
    Exp Gerontol 39:621-8. 2004
    ..As a consequence, more convenient therapies may be prepared for a complete recovery...
  95. ncbi Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis
    Irene M Rea
    Department of Geriatric Medicine, Queens University of Belfast, Whilta Medical Building, 97 Lisburn Road, Belfast BT7 9AB UK
    Exp Gerontol 39:629-35. 2004
    ....
  96. ncbi Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity
    Michelangela Barbieri
    Department of Geriatric Medicine and Metabolic Diseases, VI Divisione di Medicina Interna, II University of Naples, Piazza Miraglia 2, I 80138, Italy
    Exp Gerontol 39:1095-100. 2004
    ..Such an effect is probably due to the effect of Pro/Ala polymorphism on body composition and appears to be gender specific...
  97. ncbi Paraoxonase activity and genotype predispose to successful aging
    Francesca Marchegiani
    Center of Molecular Biology and Genetics, INRCA, Ancona, Italy
    J Gerontol A Biol Sci Med Sci 61:541-6. 2006
    ..In conclusion, we show that genetic variability at the PON1 locus is related to paraoxonase activity throughout life, and suggest that both parameters affect survival at extreme advanced age...
  98. ncbi Association between the HLA-A2 allele and Alzheimer disease
    Florinda Listi
    Immunosenescence Unit, Department of Pathobiology and Biomedical Methodology, University of Palermo, Palermo, Italy
    Rejuvenation Res 9:99-101. 2006
    ..However, it has to be taken into account that there are many molecular HLA-A2 subtypes with different frequencies in various populations. Therefore, further studies should include molecular typing of HLA-A2 subtypes...
  99. ncbi Molecular variation of human HSP90alpha and HSP90beta genes in Caucasians
    Giuseppe Passarino
    Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
    Hum Mutat 21:554-5. 2003
    ..Only three of the observed mutations altered the genic product. Interestingly, one of the variations observed was a missense mutation leading to the impairment of the hsp90alpha protein...
  100. ncbi Role of the pyrin M694V (A2080G) allele in acute myocardial infarction and longevity: a study in the Sicilian population
    Maria Paola Grimaldi
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Italy
    J Leukoc Biol 79:611-5. 2006
    ..All these data indicate a strong relationship among inflammation, genetics, CHD, and longevity...
  101. ncbi Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians
    Claudio Franceschi
    Italian National Research Center on Aging, Ancona, Italy
    Mech Ageing Dev 126:351-61. 2005
    ..We extensively screened Alu-rich genomic sites and found a new genomic region associated with longevity...