Francesco Fornai

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi request reprint The neurobiology of the spinal cord in experimental parkinsonism and Parkinson's disease
    Michela Ferrucci
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy I R C C S Neuromed, Pozzilli, Italy Email
    Arch Ital Biol 151:219-34. 2013
  2. ncbi request reprint Neurobiology and neuroanatomy of psychiatric symptoms in parkinsonism
    Francesco Fornai
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa I R C C S Neuromed, 86077 Pozzilli IS, Italy Email
    Arch Ital Biol 151:179-91. 2013
  3. ncbi request reprint Re-defining Parkinson's disease
    Francesco Fornai
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy I R C C S Neuromed, Pozzilli, Italy Email
    Arch Ital Biol 151:137-42. 2013
  4. ncbi request reprint Novel aspects of striatal plasticity associated with long-term levo-dopa administration
    Carla Letizia Busceti
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy I R C C S Neuromed, Pozzilli, Italy Email
    Arch Ital Biol 151:192-202. 2013
  5. pmc The effects of locus coeruleus and norepinephrine in methamphetamine toxicity
    Michela Ferrucci
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Curr Neuropharmacol 11:80-94. 2013
  6. pmc Lack or inhibition of dopaminergic stimulation induces a development increase of striatal tyrosine hydroxylase-positive interneurons
    Carla Letizia Busceti
    IRCCS Neuromed, Pozzilli, Italy
    PLoS ONE 7:e44025. 2012
  7. pmc Histochemical approaches to assess cell-to-cell transmission of misfolded proteins in neurodegenerative diseases
    G Natale
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Eur J Histochem 57:e5. 2013
  8. doi request reprint Future therapeutical strategies dictated by pre-clinical evidence in ALS
    Francesco Fornai
    Department of Human Morphology and Applied Biology University of Pisa, Italy
    Arch Ital Biol 149:169-74. 2011
  9. doi request reprint Genotype-, aging-dependent abnormal caspase activity in Huntington disease blood cells
    Ferdinando Squitieri
    Neurogenetics Unit and Rare Diseases Centre, IRCCS Neuromed, Pozzilli Is, Italy
    J Neural Transm 118:1599-607. 2011
  10. doi request reprint The role of locus coeruleus in the antiepileptic activity induced by vagus nerve stimulation
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Eur J Neurosci 33:2169-78. 2011

Collaborators

Detail Information

Publications81

  1. ncbi request reprint The neurobiology of the spinal cord in experimental parkinsonism and Parkinson's disease
    Michela Ferrucci
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy I R C C S Neuromed, Pozzilli, Italy Email
    Arch Ital Biol 151:219-34. 2013
    ....
  2. ncbi request reprint Neurobiology and neuroanatomy of psychiatric symptoms in parkinsonism
    Francesco Fornai
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa I R C C S Neuromed, 86077 Pozzilli IS, Italy Email
    Arch Ital Biol 151:179-91. 2013
    ..These clinicalpathological phenotypes associate with specific molecular mechanisms in the dynamics of neurobiology of disease. ..
  3. ncbi request reprint Re-defining Parkinson's disease
    Francesco Fornai
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy I R C C S Neuromed, Pozzilli, Italy Email
    Arch Ital Biol 151:137-42. 2013
    ..Such a variety of PD pathologies can be defined as monoamine brainstem disorder (MBD). ..
  4. ncbi request reprint Novel aspects of striatal plasticity associated with long-term levo-dopa administration
    Carla Letizia Busceti
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy I R C C S Neuromed, Pozzilli, Italy Email
    Arch Ital Biol 151:192-202. 2013
    ..Thus, the present article, in the attempt to describe novel mechanisms generating striatal plasticity, details these cells in development and adult life and their potential role in maturation phenomena occurring in parkinsonism. ..
  5. pmc The effects of locus coeruleus and norepinephrine in methamphetamine toxicity
    Michela Ferrucci
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Curr Neuropharmacol 11:80-94. 2013
    ..These interactions are discussed on the basis of the state of the art of the functional neuroanatomy of central NE- and DA systems. Emphasis is given to those brain sites possessing a remarkable overlapping of both neurotransmitters. ..
  6. pmc Lack or inhibition of dopaminergic stimulation induces a development increase of striatal tyrosine hydroxylase-positive interneurons
    Carla Letizia Busceti
    IRCCS Neuromed, Pozzilli, Italy
    PLoS ONE 7:e44025. 2012
    ..These data demonstrate for the first time that endogenous DA negatively regulates the number of striatal TH(+) neurons by direct and indirect mechanisms mediated by multiple DA receptor subtypes...
  7. pmc Histochemical approaches to assess cell-to-cell transmission of misfolded proteins in neurodegenerative diseases
    G Natale
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Eur J Histochem 57:e5. 2013
    ..The present manuscript comments on these phenomena aimed to provide a consistent scenario of the available histochemical approaches to dissect each specific step...
  8. doi request reprint Future therapeutical strategies dictated by pre-clinical evidence in ALS
    Francesco Fornai
    Department of Human Morphology and Applied Biology University of Pisa, Italy
    Arch Ital Biol 149:169-74. 2011
    ..On this basis the present manuscript describes which future strategies need to be pursued in order to design optimal therapeutic trial in ALS...
  9. doi request reprint Genotype-, aging-dependent abnormal caspase activity in Huntington disease blood cells
    Ferdinando Squitieri
    Neurogenetics Unit and Rare Diseases Centre, IRCCS Neuromed, Pozzilli Is, Italy
    J Neural Transm 118:1599-607. 2011
    ..Peripheral tissues (i.e. blood cells) may theoretically represent an important tool for studying HD mechanisms and searching for new biomarkers, according to the patients' genotype...
  10. doi request reprint The role of locus coeruleus in the antiepileptic activity induced by vagus nerve stimulation
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Eur J Neurosci 33:2169-78. 2011
    ..These changes may be sustained by norepinephrine alone, or in combination with its co-transmitters. In addition, vagus nerve stimulation may prevent seizures by activating the serotonin-containing dorsal raphe neurons...
  11. doi request reprint Introducing amyotrophic lateral sclerosis
    Vincenzo Silani
    Department of Human Morphology and Applied Biology University of Pisa, Italy
    Arch Ital Biol 149:1-4. 2011
    ..Similarly, novel investigations based on altered cell to cell communication are needed to further progress in understanding amyotrophic lateral sclerosis...
  12. ncbi request reprint Mechanisms involved in the formation of dopamine-induced intracellular bodies within striatal neurons
    Gloria Lazzeri
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    J Neurochem 101:1414-27. 2007
    ..In line with this, we produced subcellular alterations by administering dopamine agonists...
  13. ncbi request reprint Fine ultrastructure and biochemistry of PC12 cells: a comparative approach to understand neurotoxicity
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa I 56126, Italy
    Brain Res 1129:174-90. 2007
    ..This contrasts markedly with dopamine-containing neurons in vivo lending substance to opposite findings between these compartments concerning the sensitivity to a number of neurotoxins...
  14. ncbi request reprint DNA fragmentation and oxidative stress in the hippocampal formation: a bridge between 3,4-methylenedioxymethamphetamine (ecstasy) intake and long-lasting behavioral alterations
    Giada Frenzilli
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Behav Pharmacol 18:471-81. 2007
    ..The present data indicate that the intake of very low doses of MDMA, comparable to those consumed by humans, produces selective hippocampal alterations which may underlie cognitive impairment and seizure susceptibility...
  15. ncbi request reprint Methamphetamine produces neuronal inclusions in the nigrostriatal system and in PC12 cells
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    J Neurochem 88:114-23. 2004
    ..Inclusions were again observed when alphaMpT-treated cells were loaded with l-DOPA, which restored intracellular dopamine levels...
  16. ncbi request reprint Occurrence of neuronal inclusions combined with increased nigral expression of alpha-synuclein within dopaminergic neurons following treatment with amphetamine derivatives in mice
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Brain Res Bull 65:405-13. 2005
    ..This lends substance to the hypothesis that increased amounts of native alpha-synuclein may be per se a detrimental factor for the dopamine neurons...
  17. ncbi request reprint Locus coeruleus and neuronal plasticity in a model of focal limbic epilepsy
    Filippo S Giorgi
    Department of Neurosciences, Section of Neurology, University of Pisa, Pisa, Italy
    Epilepsia 47:21-5. 2006
    ..The purpose of this study was to evaluate the chronic effects of this new model of SE on the onset of secondary epileptogenesis. We further related the loss of noradrenaline (NE) with hippocampal mossy fiber sprouting...
  18. doi request reprint A systematic study of brainstem motor nuclei in a mouse model of ALS, the effects of lithium
    Michela Ferrucci
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Neurobiol Dis 37:370-83. 2010
    ..Moreover, in the hypoglossal nucleus, we found that recurrent collaterals were markedly lost in G93A mice while they were rescued by chronic lithium administration...
  19. ncbi request reprint Convergent roles of alpha-synuclein, DA metabolism, and the ubiquitin-proteasome system in nigrostriatal toxicity
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma, 55, I 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:84-9. 2006
    ....
  20. ncbi request reprint Nigrostriatal damage with 6-OHDA: validation of routinely applied procedures
    Federica Fulceri
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:344-8. 2006
    ..These results suggest that the flow rate and the volume of 6-OHDA infusion are critical to prevent the occurrence of nonspecific mechanical effects...
  21. doi request reprint Autophagy activation in glutamate-induced motor neuron loss
    Federica Fulceri
    Department of Human Morphology and Applied Biology University of Pisa, Italy
    Arch Ital Biol 149:101-11. 2011
    ..In this experimental conditions, pharmacological activation of autophagy rescues the loss of motor neurons...
  22. ncbi request reprint Loud noise enhances nigrostriatal dopamine toxicity induced by MDMA in mice
    Marco Gesi
    Department of Human Morphology and Applied Biology, University of Pisa, 55 56126 Pisa, Italy
    Microsc Res Tech 64:297-303. 2004
    ..Since loud noise often accompanies ecstasy intake, the present findings call for more in-depth studies aimed at disclosing the fine mechanisms underlying this enhancement...
  23. ncbi request reprint In PC12 cells neurotoxicity induced by methamphetamine is related to proteasome inhibition
    Gloria Lazzeri
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma, 55, 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:174-7. 2006
    ..The conclusions of the present article suggest that the onset of inclusion bodies represents a slight consequence of toxicity, which requires a prolonged cell viability to take place...
  24. doi request reprint Methamphetamine fails to alter the noradrenergic integrity of the heart
    Riccardo Ruffoli
    Department of Human Morphology and Applied Biology, Faculty of Medicine and Surgery, University of Pisa, Pisa, Italy
    Ann N Y Acad Sci 1139:337-44. 2008
    ....
  25. doi request reprint Pathways of methamphetamine toxicity
    Michela Ferrucci
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Ann N Y Acad Sci 1139:177-85. 2008
    ..We hypothesize that in mutant SOD1 transgenic mice, a defective autophagy might be responsible for the neurotoxic effects seen with in nigral neurons during METH toxicity...
  26. ncbi request reprint Neuronal inclusions in degenerative disorders Do they represent static features or a key to understand the dynamics of the disease?
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Brain Res Bull 65:275-90. 2005
    ....
  27. ncbi request reprint Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death after proteasome inhibition
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, I 56100 Pisa, Italy
    J Neurosci 23:8955-66. 2003
    ..These findings demonstrate that impairment of the UP system produces cell death and neuronal inclusions selectively for DA-containing neurons that depend on the occurrence of endogenous DA...
  28. doi request reprint Motor neuron pathology and behavioral alterations at late stages in a SMA mouse model
    Federica Fulceri
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma, 55, 56126, Pisa, Italy
    Brain Res 1442:66-75. 2012
    ..This provides a wonderful tool to probe novel drugs finely tuning the survival of motor neurons. In fact, small therapeutic effects protracted over considerable time intervals (even more than a year) are expected to be magnified...
  29. doi request reprint Role of autophagy during methamphetamine neurotoxicity
    Livia Pasquali
    Department of Neuroscience, Section of Neurology, University of Pisa, Pisa, Italy
    Ann N Y Acad Sci 1139:191-6. 2008
    ..Our preliminary findings rule out a detrimental role for autophagy; this represents the first step in understanding the consequence of activation of autophagy in methamphetamine toxicity...
  30. doi request reprint MPTP- but not methamphetamine-induced parkinsonism extends to catecholamine neurons in the gut
    Gianfranco Natale
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Ann N Y Acad Sci 1139:345-9. 2008
    ..These data indicate that METH did not alter the catecholamine-containing axons and autonomic neurons, while MPTP markedly reduced these components...
  31. ncbi request reprint Effects of methamphetamine on the cerebellar cortex: a preliminary study
    Michela Ferrucci
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma, 55, I 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:149-53. 2006
    ..Further investigations are needed in order to determine the time course, the cerebellar regions, the cellular (and subcellular) compartments, and the functional role related to these effects...
  32. ncbi request reprint Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium
    Francesco Fornai
    Department of Human Morphology and Applied Biology, Faculty of Medicine, University of Pisa, Italy
    Autophagy 4:527-30. 2008
    ..In particular, the biogenesis of mitochondria and the increase of calbindin D 28K-positive neurons, which are likely to support powerful neuroprotection towards autophagy failure, mitochondriopathy and neuronal loss in the spinal cord...
  33. ncbi request reprint The role of norepinephrine in epilepsy: from the bench to the bedside
    Filippo S Giorgi
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, 56100 Pisa, Italy
    Neurosci Biobehav Rev 28:507-24. 2004
    ..Finally, recent data demonstrate that NE loss increases neuronal damage following focally induced limbic status epilepticus, confirming a protective effect of brain NE, which has already been shown in other neurological disorders...
  34. ncbi request reprint Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy
    Carla Letizia Busceti
    I N M Neuromed, Pozzilli, Italy
    Epilepsia 48:694-705. 2007
    ....
  35. doi request reprint High number of striatal dopaminergic neurons during early postnatal development: correlation analysis with dopaminergic fibers
    Carla L Busceti
    IRCCS INM Neuromed, Pozzilli, Italy
    J Neural Transm 115:1375-83. 2008
    ..A better knowledge of the mechanisms regulating the ontogenesis of the nigrostriatal DA system may pave the way to strategies of neurorescue of the DA system...
  36. ncbi request reprint Dopamine stimulation via infusion in the lateral ventricle
    Francesca Biagioni
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma, 55, I 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:337-43. 2006
    ..These results offer a more reliable and safe therapeutic approach to deliver continuous DA selectively in the brain...
  37. ncbi request reprint Ecstasy during loud noise exposure induces dramatic ultrastructural changes in the heart
    Marco Gesi
    Department of Human Morphology and Applied Biology, University of Pisa, Italy
    Pharmacol Toxicol 91:29-33. 2002
    ..In contrast, alterations were visible at the ultrastructural level as mitochondrial changes. In particular, we found a marked enhancement in the number of altered mitochondria when MDMA was administered during exposure to loud noise...
  38. doi request reprint Activation of brain metabolism and fos during limbic seizures: the role of locus coeruleus
    Filippo S Giorgi
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Neurobiol Dis 30:388-99. 2008
    ..This might have relevant effects in the plastic mechanisms related with epileptogenesis...
  39. doi request reprint Intermittent Dopaminergic stimulation causes behavioral sensitization in the addicted brain and parkinsonism
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Int Rev Neurobiol 88:371-98. 2009
    ..In line with this view is the growing evidence of addictive behaviors in PD patients during the course of DA-replacement therapy...
  40. doi request reprint Autophagy, lithium, and amyotrophic lateral sclerosis
    Livia Pasquali
    Department of Neuroscience, Clinical Neurology, University of Pisa, Pisa, Italy
    Muscle Nerve 40:173-94. 2009
    ..Again, lithium has been reported to decrease glial proliferation in the ALS spinal cord and induces sprouting in corticospinal fibers. Muscle Nerve 40: 173-194, 2009...
  41. doi request reprint MPTP-induced parkinsonism extends to a subclass of TH-positive neurons in the gut
    Gianfranco Natale
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Brain Res 1355:195-206. 2010
    ....
  42. ncbi request reprint Inclusion dynamics in PC12 is comparable between amphetamines and MPTP
    Marco Gesi
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma, 55, I 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:315-9. 2006
    ..This suggests that formation of inclusions is a multi-step process that might be elicited by different stimuli and, once triggered, leads to the same final effect...
  43. pmc Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, 56126 Pisa, Italy
    Proc Natl Acad Sci U S A 102:3413-8. 2005
    ..These data suggest that continuous low-level exposure of mice to MPTP causes a Parkinson-like syndrome in an alpha-synuclein-dependent manner...
  44. ncbi request reprint Noradrenaline in Parkinson's disease: from disease progression to current therapeutics
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Curr Med Chem 14:2330-4. 2007
    ..In the last part, we overview novel therapeutic approaches aimed at restoring the activation of noradrenaline receptors to reduce the dyskinesia occurring in the treatment of Parkinson's disease...
  45. doi request reprint Lack of alpha 1b-adrenergic receptor protects against epileptic seizures
    Chiara Pizzanelli
    Unit of Neurophysiopathology, Hospital F Lotti, Pontedera, Pisa, Italy
    Epilepsia 50:59-64. 2009
    ..Therefore, one should expect that the blockade of alpha 1b-AR leads to anticonvulsant and neuroprotective effects. However, the lack of alpha 1b-AR antagonists does not allow testing of this hypothesis...
  46. ncbi request reprint The role of autophagy: what can be learned from the genetic forms of amyotrophic lateral sclerosis
    Livia Pasquali
    Department of Neuroscience, Clinical Neurology, University of Pisa, Pisa, Italy
    CNS Neurol Disord Drug Targets 9:268-78. 2010
    ..These novel insights into the pathogenesis of ALS may lead to the identification of novel strategies to promote motor neuron survival...
  47. doi request reprint Intracellular pathways underlying the effects of lithium
    Livia Pasquali
    Department of Neuroscience, University of Pisa, Pisa, Italy
    Behav Pharmacol 21:473-92. 2010
    ..This review is an attempt to elucidate the primary effects of lithium to interconnect the simpler targets to the most complex pharmacological effects...
  48. ncbi request reprint Morphological alterations induced by loud noise in the myocardium: the role of benzodiazepine receptors
    Marco Gesi
    Department of Human Morphology and Applied Biology, School of Medicine, University of Pisa, 56126 Pisa, Italy
    Microsc Res Tech 59:136-46. 2002
    ....
  49. doi request reprint Involvement of dopamine receptors and beta-arrestin in metamphetamine-induced inclusions formation in PC12 cells
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    J Neurochem 105:1939-47. 2008
    ..In conclusion, the present study demonstrates the involvement of beta-arrestin in MA-induced intracellular bodies and the participation of dopamine receptors in this process...
  50. ncbi request reprint MDMA induces caspase-3 activation in the limbic system but not in striatum
    Ilaria Tamburini
    Department of Human Morphology and Applied Biology, Univerity of Pisa, Via Roma 55, 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:377-81. 2006
    ..Potential implications and pitfalls of such an experimental observation are reported...
  51. pmc Effects of loud noise exposure on DNA integrity in rat adrenal gland
    Giada Frenzilli
    Dipartimento di Morfologia Umana e Biologia Applicata, University of Pisa, Pisa, Italy
    Environ Health Perspect 112:1671-2. 2004
    ..Genetic alterations did not decrease 24 hr after the cessation of the stimulus. We hypothesize that an imbalance of redox cell status is responsible for the induction and persistence of noise-induced cellular damage...
  52. ncbi request reprint MDMA and seizures: a dangerous liaison?
    Filippo S Giorgi
    M D Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:357-64. 2006
    ..In the present article, we reviewed these studies and we report our preliminary experimental data documenting the lack of mossy fiber sprouting at short time intervals following MDMA, when seizure susceptibility is already present...
  53. doi request reprint Abnormal morphology of peripheral cell tissues from patients with Huntington disease
    Ferdinando Squitieri
    Neurogenetics Unit, IRCCS Neuromed and Centre for Rare Diseases, Localita Camerelle, 86077, Pozzilli Is, Italy
    J Neural Transm 117:77-83. 2010
    ..Moreover, the occurrence of ultrastructural cell pathology reminiscent of neuronal degeneration in HD, suggests the use of human peripheral cells as a tool to investigate the pathogenic cascade subsequent to huntingtin dysregulation...
  54. doi request reprint Analysis of single, purified inclusions as a novel approach to understand methamphetamine neurotoxicity
    Paola Lenzi
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Ann N Y Acad Sci 1139:186-90. 2008
    ....
  55. pmc DNA damage associated with ultrastructural alterations in rat myocardium after loud noise exposure
    Paola Lenzi
    Dipartimento di Morfologia Umana e Biologia Applicata, University of Pisa, Pisa, Italy
    Environ Health Perspect 111:467-71. 2003
    ..An elevated oxyradical generation, possibly related to altered sympathetic innervation, is hypothesized as responsible for the induction and persistence of noise-induced cellular damage...
  56. pmc Lithium delays progression of amyotrophic lateral sclerosis
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa 56100 Pisa, Italy
    Proc Natl Acad Sci U S A 105:2052-7. 2008
    ..All these mechanisms may contribute to the effects of lithium, and these results offer a promising perspective for the treatment of human patients affected by ALS...
  57. ncbi request reprint The neurotoxicity of amphetamines: bridging drugs of abuse and neurodegenerative disorders
    Luisa Iacovelli
    Lab of Neurobiology of Movement Disorders, I R C C S I N M Neuromed Loc Camerelle, Pozzilli Is, Italy
    Exp Neurol 201:24-31. 2006
    ....
  58. doi request reprint The chemical neuroanatomy of vagus nerve stimulation
    Riccardo Ruffoli
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, 56100 Pisa, Italy
    J Chem Neuroanat 42:288-96. 2011
    ..This refers both to the antiepileptic effects and most recently to the beneficial effects of vagal stimulation in mood and cognitive disorders...
  59. doi request reprint Does autophagy worsen or improve the survival of dopaminergic neurons?
    Livia Pasquali
    Department of Neuroscience, Clinical Neurology, University of Pisa, Pisa, Italy
    Parkinsonism Relat Disord 15:S24-7. 2009
    ..Taken together, this evidence suggests that autophagy improves the survival of dopaminergic cells...
  60. ncbi request reprint The "Parkinsonian heart": from novel vistas to advanced therapeutic approaches in Parkinson's disease
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Curr Med Chem 14:2421-8. 2007
    ..Therefore, we suggest that binding to these receptor subtypes, joined with the lack of endogenous noradrenergic innervation, might synergize to produce the cardiac fibrosis...
  61. doi request reprint Protein clearing pathways in ALS
    Michela Ferrucci
    Department of Human Morphology and Applied Biology University of Pisa, Italy
    Arch Ital Biol 149:121-49. 2011
    ..Conversely stimulation of autophagy alleviates motor neuron degeneration.Therefore, autophagy represents an important target when developing novel treatments in ALS...
  62. pmc Transmission of prions within the gut and towards the central nervous system
    Gianfranco Natale
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Prion 5:142-9. 2011
    ..The glycation of prion protein to form advanced glycation end-products (AGE) interacting with specific receptors placed on neighboring cells (RAGE) represents the key hypothesis to be discussed...
  63. ncbi request reprint A damage to locus coeruleus neurons converts sporadic seizures into self-sustaining limbic status epilepticus
    Filippo S Giorgi
    Department of Neurosciences, Section of Neurology, University of Pisa, Italy
    Eur J Neurosci 17:2593-601. 2003
    ..This study demonstrates a powerful effect of noradrenergic terminals in regulating the onset of limbic status epilepticus and its sensitivity to specific glutamate antagonists...
  64. doi request reprint MPTP-induced Parkinsonism is associated with damage to Leydig cells and testosterone loss
    Riccardo Ruffoli
    Department of Human Morphology and Applied Biology, University of Pisa Via Roma, 55 56126 Pisa, Italy
    Brain Res 1229:218-23. 2008
    ..These effects shed novel light to understand genital dysfunction and testosterone deficiency in Parkinsonism, while offering a new experimental model to reproduce genital dysfunction in Parkinson's disease...
  65. ncbi request reprint Overexpression of alpha-synuclein following methamphetamine: is it good or bad?
    Giuseppe Mauceli
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma, 55, I 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:191-7. 2006
    ....
  66. pmc 3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one, a novel adenosine receptor antagonist with A(2A)-mediated neuroprotective effects
    Alessia Scatena
    Dipartimento di Morfologia Umana e Biologia Applicata, Universita di Pisa, Via Roma 55, 56126 Pisa, Italy
    ACS Chem Neurosci 2:526-35. 2011
    ....
  67. ncbi request reprint Resistance to striatal dopamine depletion induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice expressing human mutant Cu,Zn superoxide dismutase
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Neurosci Lett 325:124-8. 2002
    ..Our results indicate that overexpression of both wild-type and human mutant SOD1 induces comparable neuroprotective effects against striatal dopaminergic depletion...
  68. ncbi request reprint Expression of 3-nitrotyrosine, a marker for peroxynitrite, in nasal polyps of nonatopic patients
    Francesco Giannessi
    Department of Human Morphology and Applied Biology, Faculty of Medicine and Surgery, University of Pisa, Pisa, Italy
    Med Sci Monit 16:CR172-179. 2010
    ..This study aimed to assess the distribution of peroxynitrite in nasal polyps from nonatopic patients. Occurrence of peroxynitrite also was analyzed in relation with eosinophil infiltration and epithelial alterations...
  69. doi request reprint Alpha-synuclein and autophagy as common steps in neurodegeneration
    Michela Ferrucci
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, Pisa, Italy
    Parkinsonism Relat Disord 14:S180-4. 2008
    ..We then indicate a protective role of autophagy in PD and suggest it as a therapeutic target to slow down the progression of the disease...
  70. doi request reprint Lithium in ALS: from the bench to the bedside
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Italy
    Amyotroph Lateral Scler 9:123-4. 2008
  71. ncbi request reprint Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation
    Ferdinando Squitieri
    Neurogenetics Unit, IRCCS Neuromed, Pozzilli, IS, Italy
    Mech Ageing Dev 127:217-20. 2006
    ..We argue that early mitochondrial impairment at basal level may affect the severity of HD progression in patients...
  72. doi request reprint Strategies for clinical approach to neurodegeneration in Amyotrophic lateral sclerosis
    Cecilia Carlesi
    Department of Neuroscience, Clinical Neurology, University of Pisa, Pisa, Italy
    Arch Ital Biol 149:151-67. 2011
    ..Here we review some of the recent progress in promoting therapeutic strategies for neurodegeneration...
  73. ncbi request reprint Comparison between heroin and heroin-cocaine polyabusers: a psychopathological study
    Adolfo Bandettini di Poggio
    Department of Human Morphology and Applied Biology, Via Roma 55, 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:438-45. 2006
    ..Results show a direct relationship between cocaine abuse and a higher rate of psychiatric disorders, but a negative correlation with the severity of self-rated psychopathology...
  74. ncbi request reprint Morphological evidence that xenon neuroprotects against N-methyl-DL-aspartic acid-induced damage in the rat arcuate nucleus: a time-dependent study
    Gianfranco Natale
    Department of Human Morphology and Applied Biology, University of Pisa, Via Roma 55, I 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:650-8. 2006
    ..Xenon significantly reduced the neuronal damage at all times and can be then regarded as a promising neuroprotectant agent...
  75. ncbi request reprint The comet assay as a method of assessment of neurotoxicity: usefulness for drugs of abuse
    Giada Frenzilli
    Dipartimento di Morfologia Umana, E Biologia Applicata, Universita di Pisa, Via Volta, 4, I 56126 Pisa, Italy
    Ann N Y Acad Sci 1074:478-81. 2006
    ..The present article summarizes some data from our and other groups underlining the suitability of the Comet assay in assessing neurotoxicity and its potential in evaluating drugs of abuse-related genotoxicity...
  76. pmc Brief and repeated noise exposure produces different morphological and biochemical effects in noradrenaline and adrenaline cells of adrenal medulla
    Marco Gesi
    Department of Human Morphology and Applied Biology, School of Medicine, University of Pisa, Italy
    J Anat 200:159-68. 2002
    ..In addition, adrenaline cells also exhibited ultrastructural alterations consisting of wide homogeneous cytoplasmic areas and large, pale vesicles...
  77. ncbi request reprint Effects of loud noise exposure on mouse myocardium: a comparison with the rat
    Marco Gesi
    Department of Human Morphology and Applied Biology, School of Medicine, University of Pisa Via Roma, 55 56126 Pisa Italy
    Microsc Res Tech 59:131-5. 2002
    ....
  78. ncbi request reprint Is there a role for uridine and pyrimidine nucleosides in the treatment of vascular dementia?
    Francesco Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Italy
    Funct Neurol 17:93-9. 2002
    ..Pyrimidine nucleosides might be useful in the chronic treatment of cognitive deficits resulting from vascular dementia...
  79. ncbi request reprint Morphological effects in the mouse myocardium after methylenedioxymethamphetamine administration combined with loud noise exposure
    Marco Gesi
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Anat Rec 267:37-46. 2002
    ..Remarkably, this enhancement was evident both as a decrease in the threshold dose of MDMA necessary to alter the myocardial ultrastructure, and as an increase in myocardial alterations produced by a higher dose of MDMA...
  80. ncbi request reprint Increased prevalence of pervasive developmental disorders in children with slight arylsulfatase A deficiency
    Maria Grazia Alessandri
    Division of Child Neurology and Psychiatry, IRCCS Stella Maris, Via dei Giacinti 2, I 56018 Calambrone, Pisa, Italy
    Brain Dev 24:688-92. 2002
    ..This suggests that arylsulfatase A slight deficiency could be a marker of a subclass of pervasive developmental disorders...
  81. doi request reprint A subcellular analysis of genetic modulation of PINK1 on mitochondrial alterations, autophagy and cell death
    P Lenzi
    Department of Human Morphology and Applied Biology, University of Pisa, Italy
    Arch Ital Biol 150:194-217. 2012
    ..These findings highlight the strong neuroprotective role of PINK1 as a key protein in the surveillance and regulation of mitochondrial homeostasis...