Research Topics
Genomes and Genes | Luca FontanesiSummaryAffiliation: University of Bologna Country: Italy Publications
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Detail Information
Publications
The TBC1D1 gene: structure, function, and association with obesity and related traitsLuca Fontanesi
Department of Agricultural and Food Sciences DISTAL, University of Bologna, Bologna, Italy
Vitam Horm 91:77-95. 2013..In chicken, a few quantitative trait loci for growth and fat deposition were localized in the region containing TBC1D1. These complementary results could contribute to further understand the role of TBC1D1 in developing obesity...- Nucleotide variability and haplotype heterogeneity at the porcine fat mass and obesity-associated (FTO) geneL Fontanesi
Department of Agro Food Science and Technology, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Viale Fanin 48, 40127, Bologna, Italy
Anim Genet 44:96-100. 2013.... - Polymorphisms in an obesity-related gene (PCSK1) are associated with fat deposition and production traits in Italian heavy pigsL Fontanesi
Department of Agro Food Science and Technology, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Viale Fanin 48, 40127 Bologna, Italy
Animal 6:1913-24. 2012..The results obtained supported the need to further investigate the PCSK1 gene to fully exploit the value of its variability and apply this information in pig breeding programmes... 
A genome wide association study for backfat thickness in Italian Large White pigs highlights new regions affecting fat deposition including neuronal genesLuca Fontanesi
Department of Agricultural and Food Science and Technology, University of Bologna, Viale Fanin 46, Bologna 40127, Italy
BMC Genomics 13:583. 2012....- Exploring copy number variation in the rabbit (Oryctolagus cuniculus) genome by array comparative genome hybridizationL Fontanesi
Department of Agro Food Science and Technology, Sezione di Allevamenti Zootecnici, University of Bologna, Viale Fanin 48, 40127 Bologna, Italy
Genomics 100:245-51. 2012..Many rabbit CNVRs might have a functional relevance that should be further investigated... - Identification and association analysis of several hundred single nucleotide polymorphisms within candidate genes for back fat thickness in Italian Large White pigs using a selective genotyping approachL Fontanesi
Department of Agro Food Science and Technology, Sezione di Allevamenti Zootecnici, University of Bologna, Viale Fanin 46, 40127 Bologna, Italy
J Anim Sci 90:2450-64. 2012..Because of similarities between humans and pigs, this study might also provide useful clues to investigate genetic factors affecting human obesity... - Analysis of association between the MUC4 g.8227C>G polymorphism and production traits in Italian heavy pigs using a selective genotyping approachLuca Fontanesi
Dept of Agro Food Science and Technology, Sezione di Allevamenti Zootecnici, University of Bologna, Bologna, Italy
Anim Biotechnol 23:147-55. 2012..Antagonistic associations of the MUC4 g.8227C>G alleles on susceptibility to ETEC and growth performances evidence the complexity of applying marker assisted selection in pig breeding... - Haplotype variability in the bovine MITF gene and association with piebaldism in Holstein and Simmental cattle breedsL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Italy
Anim Genet 43:250-6. 2012.... 
Coat colours in the Massese sheep breed are associated with mutations in the agouti signalling protein (ASIP) and melanocortin 1 receptor (MC1R) genesL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, University of Bologna, Via F lli Rosselli 107, 42100 Reggio Emilia, Italy
Animal 5:8-17. 2011..5172T], [N:g.5172A] and [D(5):g.5172A]) were detected (organized into six different diplotypes). In conclusion, the results indicated that coat colours in the Massese sheep breed are mainly derived by combining ASIP and MC1R mutations...- Characterization of the rabbit agouti signaling protein (ASIP) gene: transcripts and phylogenetic analyses and identification of the causative mutation of the nonagouti black coat colourLuca Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, University of Bologna, Via F lli Rosselli 107, 42100 Reggio Emilia, Italy
Genomics 95:166-75. 2010..ASIP gene transcripts were also detected in all examined rabbit tissues distinguishing the rabbit expression pattern from what was observed in wild type mice... - Copy number variation and missense mutations of the agouti signaling protein (ASIP) gene in goat breeds with different coat colorsL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, University of Bologna, IT 42100 Reggio Emilia, Italy
Cytogenet Genome Res 126:333-47. 2009..However, other mechanisms may also be involved in determining coat color in these 2 breeds... - Association between cathepsin L (CTSL) and cathepsin S (CTSS) polymorphisms and meat production and carcass traits in Italian Large White pigsL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
Meat Sci 85:331-8. 2010..Overall these results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs... - The insulin-like growth factor 2 (IGF2) gene intron3-g.3072G>A polymorphism is not the only Sus scrofa chromosome 2p mutation affecting meat production and carcass traits in pigs: evidence from the effects of a cathepsin D (CTSD) gene polymorphismL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
J Anim Sci 88:2235-45. 2010..However, for practical applications, because the CTSD gene should not be imprinted (we obtained this information from expression analysis in adult skeletal muscle), the different modes of inheritance of the 2 genes have to be considered... - Genetic heterogeneity and selection signature at the KIT gene in pigs showing different coat colours and patternsL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, Reggio Emilia, Italy
Anim Genet 41:478-92. 2010..Phylogenetic relationships of 28 inferred KIT haplotypes indicated two clades: one of Asian origin that included Meishan and a few Sicilian black haplotypes and another of European origin... - The porcine tribbles homolog 3 (TRIB3) gene: Identification of a missense mutation and association analysis with meat quality and production traits in Italian heavy pigsL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
Meat Sci 86:808-13. 2010..1 and P<0.05). This polymorphism tended to be associated with lactate content of the semimembranosus muscle (P<0.1). Among several other tissues, TRIB3 is expressed in fat and skeletal muscle... - The porcine TBC1D1 gene: mapping, SNP identification, and association study with meat, carcass and production traits in Italian heavy pigsLuca Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42100, Reggio Emilia, Italy
Mol Biol Rep 38:1425-31. 2011..The g.219G>A SNP was associated (P < 0.05) with ham weight, back fat thickness and lean cuts content in Italian Large White and with visible intermuscular fat in Italian Duroc pigs... - An initial comparative map of copy number variations in the goat (Capra hircus) genomeLuca Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
BMC Genomics 11:639. 2010.... - A first comparative map of copy number variations in the sheep genomeL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
Genomics 97:158-65. 2011..0001), suggesting that several chromosome regions might contain recurrent interspecies CNVRs. Many sheep CNVRs include genes with important biological functions. Further studies are needed to evaluate their functional relevance... - A melanocortin 1 receptor (MC1R) gene polymorphism is useful for authentication of Massese sheep dairy productsLuca Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
J Dairy Res 78:122-8. 2011..To our knowledge, this system represents the first one that can be used for breed authentication of a sheep production and that, at the same time, can reveal frauds derived from the admixture of milk of an unreported species... - Microarray gene expression analysis of porcine skeletal muscle sampled at several post mortem time pointsL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
Meat Sci 88:604-9. 2011..These results open new perspectives to develop and analyse gene expression biomarkers for pig production and product authentication... - Association between polymorphisms in cathepsin and cystatin genes with meat production and carcass traits in Italian Duroc pigs: confirmation of the effects of a cathepsin L (CTSL) gene markerLuca Fontanesi
Faculty of Agriculture, DIPROVAL, Sezione di Allevamenti Zootecnici, University of Bologna, Via F lli Rosselli 107, 42123, Reggio Emilia, re, Italy
Mol Biol Rep 39:109-15. 2012..05). The results we obtained in the Italian Duroc pigs confirmed the results and the direction of the effects already reported for the Italian Large White breed... - Genetic heterogeneity at the bovine KIT gene in cattle breeds carrying different putative alleles at the spotting locusL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
Anim Genet 41:295-303. 2010.... - Missense and nonsense mutations in melanocortin 1 receptor (MC1R) gene of different goat breeds: association with red and black coat colour phenotypes but with unexpected evidencesLuca Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, University of Bologna, 42100 Reggio Emilia, Italy
BMC Genet 10:47. 2009..The Extension locus encodes the melanocortin 1 receptor (MC1R) whose permanent activation, caused by functional mutations, results in black coat colour, whereas other inactivating mutations cause red coat colour in different mammals... - A single nucleotide polymorphism in the porcine cathepsin K (CTSK) gene is associated with back fat thickness and production traits in Italian Duroc pigsLuca Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Reggio Emilia, Italy
Mol Biol Rep 37:491-5. 2010..Association analysis including all Italian Duroc pigs showed that the CTSK marker was associated with back fat thickness and lean cuts (P < 0.01), and average daily gain and feed:gain ratio (P < 0.05) estimated breeding values... - Confirmed association between a single nucleotide polymorphism in the FTO gene and obesity-related traits in heavy pigsLuca Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Reggio Emilia, Italy
Mol Biol Rep 37:461-6. 2010..01) and in the commercial pigs (intramuscular fat content of different muscles, P < 0.05 or P < 0.10; lean meat content, P < 0.05; BFT, P < 0.05; intermuscular fat content in the hams, P < 0.05)... - The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigsL Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42100 Reggio Emilia, Italy
Anim Genet 40:90-3. 2009..00001, P<0.001 and P<0.0001, considering all animals or only two- or three-generation unrelated animals respectively), indicating association between the analysed FTO marker and intermuscular fat deposition... - A composite six bp in-frame deletion in the melanocortin 1 receptor (MC1R) gene is associated with the Japanese brindling coat colour in rabbits (Oryctolagus cuniculus)Luca Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, University of Bologna, Via F, lli Rosselli 107, 42123 Reggio Emilia, Italy
BMC Genet 11:59. 2010..280_285del6; alleles ED or ES) and recessive red (c.304_333del30; allele e) coat colours. It remained to characterize the eJallele whose phenotypic effect is similar to the Orange and Sex-linked yellow loci of cat and Syrian hamster... - Differences of the porcine amelogenin X and Y chromosome genes (AMELX and AMELY) and their application for sex determination in pigsLuca Fontanesi
Faculty of Agriculture, DIPROVAL, Sezione di Allevamenti Zootecnici, University of Bologna, Reggio Emilia, Italy
Mol Reprod Dev 75:1662-8. 2008..Thus, apart from the application in the reproduction field, these tests can be useful in several other sectors including forensics, archaeozoology, meat production, and processing as well as for quality control in sample identification... - Mutations in the melanocortin 1 receptor (MC1R) gene are associated with coat colours in the domestic rabbit (Oryctolagus cuniculus)L Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, Villa Levi Coviolo, 42100 Reggio Emilia, Italy
Anim Genet 37:489-93. 2006..Following the nomenclature established for the rabbit extension locus, the c.280_285del6 allele, which is dominant over c.304_333del30, may be allele E(D) or allele E(S)... - Linkage mapping of the porcine cathepsin F (CTSF) gene close to the QTL regions for meat and fat deposition traits on pig chromosome 2V Russo
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F.lli Rosselli 107, Villa Levi--Coviolo, 42100 Reggio Emilia, Italy
Anim Genet 35:155-7. 2004 - Isolation and mapping of two porcine skeletal muscle myosin heavy chain isoformsR Davoli
DIPROVAL, University of Bologna, Reggio Emilia, Italy
Anim Genet 29:91-7. 1998.... - The porcine proteasome subunit A4 (PSMA4) gene: isolation of a partial cDNA, linkage and physical mappingR Davoli
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Reggio Emilia, Italy
Anim Genet 29:385-8. 1998..Moreover, the 3'-untranslated region of the gene showed a triallelic SSCP. By linkage analysis the PSMA4 locus was assigned to pig chromosome 7 and by radioactive in situ hybridization this locus was mapped to the region 7q13-q14... - Single nucleotide polymorphisms in several porcine cathepsin genes are associated with growth, carcass, and production traits in Italian Large White pigsV Russo
Dipartimento di Protezione e Valorizzazione Agroalimentare, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, 42100 Reggio Emilia, Italy
J Anim Sci 86:3300-14. 2008..029). The biochemical and physiological functions of the lysosomal proteinases, together with the results obtained in our investigation, suggest that the cathepsin gene family might play important roles affecting economic traits in pigs... - Investigation of candidate genes for meat quality in dry-cured ham production: the porcine cathepsin B (CTSB) and cystatin B (CSTB) genesV Russo
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F.lli Rosselli, Villa Levi - Coviolo, Reggio Emilia, Italy
Anim Genet 33:123-31. 2002..Significant associations were observed between CTSB and back-fat thickness and between CSTB and average daily gain. In this study, cathepsin B activity was not associated with the polymorphisms identified at the CTSB and CSTB loci... - Analysis of expressed sequence tags of porcine skeletal muscleR Davoli
DIPROVAL, Sezione di Allevamenti Zootecnici, University of Bologna, Via F lli Rosselli 107, Coviolo, 42100 Reggio Emilia, Italy
Gene 233:181-8. 1999..The results of our analysis allowed the establishment of a first list of genes expressed in porcine skeletal muscle... - Isolation of porcine expressed sequence tags for the construction of a first genomic transcript map of the skeletal muscle in pigR Davoli
DIPROVAL Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Reggio Emilia, Italy
Anim Genet 33:3-18. 2002..The mapping of these cDNAs contributed to the construction of a first genomic transcript map of the skeletal muscle tissue in pig... - A missense mutation in the porcine mitochondrial 2,4-dienoyl CoA reductase 1 (DECR1) gene and linkage mapping of this locus to chromosome 4R Davoli
DIPROVAL - Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F.lli Rosselli 107, Villa Levi - Coviolo, Reggio Emilia, Italy
Anim Genet 33:73-5. 2002 - Identification of SNPs, mapping and analysis of allele frequencies in two candidate genes for meat production traits: the porcine myosin heavy chain 2B (MYH4) and the skeletal muscle myosin regulatory light chain 2 (HUMMLC2B)R Davoli
DIPROVAL Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, Villa Levi Coviolo, 42100 Reggio Emilia, Italy
Anim Genet 34:221-5. 2003.... - Radiation hybrid mapping of three skeletal muscle genes (CKM, ECH1 and TNNT1) to porcine chromosome 6R Davoli
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via Fratelli Rosselli, 107, Villa Levi, Coviolo, I-42100, Reggio Emilia, Italy
Anim Genet 34:302-3. 2003 - The porcine fast skeletal muscle troponin T3 (TNNT3) gene: identification of mutations and linkage mapping to chromosome 2R Davoli
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F.lli Rosselli 107, Villa Levi - Coviolo, 42100 Reggio Emilia, Italy
Anim Genet 34:391-2. 2003 - Study of candidate genes for glycolytic potential of porcine skeletal muscle: identification and analysis of mutations, linkage and physical mapping and association with meat quality traits in pigsL Fontanesi
DIPROVAL Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Reggio Emilia, Italy
Cytogenet Genome Res 102:145-51. 2003..PGAM2 and PKM2 were significantly associated (P = 0.01) with drip loss percentage and glycogen content at one hour post mortem, respectively... - Genetic structure of candidate genes for litter size in Italian Large White pigsS Dall'Olio
Dipartimento di Protezione e Valorizzazione Agroalimentare, Universita degli Studi di Bologna, Sezione di Allevamenti Zootecnici, Reggio Emilia, Italy
Vet Res Commun 34:S203-6. 2010.... - Mapping, identification of polymorphisms and analysis of allele frequencies in the porcine skeletal muscle myopalladin and titin genesR Davoli
DIPROVAL Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Reggio Emilia, Italy
Cytogenet Genome Res 102:152-6. 2003..Further studies are needed to test the presence of a putative effect of myopalladin on lean meat content... - Sexing European rabbits (Oryctolagus cuniculus), European brown hares (Lepus europaeus) and mountain hares (Lepus timidus) with ZFX and ZFY lociLuca Fontanesi
DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via Fratelli Rosselli 107, 42100 Reggio Emilia, Italy Centro di Ecologia Alpina, Viote del Monte Bondone, 38040 Trento, Italy Department of Botany and Zoology, Evolutionary Genomics Group, University of Stellenbosch, PB X1, Matieland 7602, South Africa
Mol Ecol Resour 8:1294-6. 2008..Among several applications, this PCR-RFLP method could be used to investigate gender ratio and evaluate the population dynamics of these species using samples collected when sex cannot be identified... - Characterization of a SINE indel polymorphism in the porcine AGL gene and assignment of the gene to chromosome 4qA Stratil
Institute of Animal Physiology and Genetics, Academy of Sciences of the Czech Republic, 277 21 Libechov, Czech Republic
Anim Genet 34:146-8. 2003 - Quantitative trait loci affecting milk yield and protein percentage in a three-country Brown Swiss populationA Bagnato
Department of Veterinary Sciences and Technologies for Food Safety, Universita degli Studi di Milano, 20133 Milano, Italy
J Dairy Sci 91:767-83. 2008.... - Associations of functional candidate genes derived from gene-expression profiles of prenatal porcine muscle tissue with meat quality and muscle depositionK Wimmers
Research Institute for the Biology of Farm Animals FBN, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
Anim Genet 38:474-84. 2007..The polymorphisms detected are not likely causal, but markers were identified that are in linkage disequilibrium with causal genetic variation within particular populations... - Analysis of the MC1R gene in the Nero Siciliano pig breed and usefulness of this locus for breed traceabilityL Fontanesi
Department of Morphology, Biochemistry, Physiology and Animal Production, Section of Animal Production, Faculty of Veterinary Medicine, Messina, Italy
Vet Res Commun 31:389-92. 2007