L Fiume

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Albumin-drug conjugates in the treatment of hepatic disorders
    Luigi Fiume
    University of Bologna, Department of Experimental, Diagnostic and Specialty Medicine, via San Giacomo 14 20126 Bologna, Italy 39 0512094700 39 0512094746
    Expert Opin Drug Deliv 11:1203-17. 2014
  2. ncbi Lactosaminated human albumin, a hepatotropic carrier of drugs
    Luigi Fiume
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, I 40126 Bologna, Italy
    Eur J Pharm Sci 40:253-62. 2010
  3. ncbi The enhancement of interstitial transport of a doxorubicin-lactosaminated albumin conjugate by imatinib: in rat hepatocellular carcinoma it is not preferentially higher than that in liver and bone marrow
    L Fiume
    Department of Experimental Pathology, University of Bologna, Italy
    Eur J Pharm Biopharm 72:630-1. 2009
  4. ncbi Doxorubicin coupled to lactosaminated human albumin: a hepatocellular carcinoma targeted drug
    Luigi Fiume
    Department of Experimental Pathology, University of Bologna, Italy
    Drug Discov Today 13:1002-9. 2008
  5. ncbi Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine
    Luigi Fiume
    Department of Experimental Pathology, University of Bologna, Via San Giacomo, 14 40126 Bologna, Italy
    J Hepatol 43:645-52. 2005
  6. ncbi Doxorubicin coupled to lactosaminated albumin: Effects on rats with liver fibrosis and cirrhosis
    G Di Stefano
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Dig Liver Dis 38:404-8. 2006
  7. ncbi Efficacy of doxorubicin coupled to lactosaminated albumin on rat hepatocellular carcinomas evaluated by ultrasound imaging
    G Di Stefano
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Dig Liver Dis 40:278-84. 2008
  8. ncbi Coupling of 5-fluoro 2'-deoxyuridine to lactosaminated poly-l-lysine: an approach to a regional, non-invasive chemotherapy of liver micrometastases
    G Di Stefano
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126, Bologna, Italy
    Biochem Pharmacol 61:459-65. 2001
  9. ncbi Floxuridine coupling with lactosaminated human albumin to increase drug efficacy on liver micrometastases
    G Di Stefano
    Department of Experimental Pathology, University of Bologna, Italy
    Dig Liver Dis 34:439-46. 2002
  10. ncbi Doxorubicin coupled to lactosaminated human albumin remains confined within mouse liver cells after the intracellular release from the carrier
    G Di Stefano
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Dig Liver Dis 35:428-33. 2003

Collaborators

Detail Information

Publications12

  1. ncbi Albumin-drug conjugates in the treatment of hepatic disorders
    Luigi Fiume
    University of Bologna, Department of Experimental, Diagnostic and Specialty Medicine, via San Giacomo 14 20126 Bologna, Italy 39 0512094700 39 0512094746
    Expert Opin Drug Deliv 11:1203-17. 2014
    ..In the future, conjugation to SA could remain a successful strategy to permit the administration of drugs with rapid resolutive effects inside liver cells without causing severe extrahepatic adverse reactions. ..
  2. ncbi Lactosaminated human albumin, a hepatotropic carrier of drugs
    Luigi Fiume
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, I 40126 Bologna, Italy
    Eur J Pharm Sci 40:253-62. 2010
    ....
  3. ncbi The enhancement of interstitial transport of a doxorubicin-lactosaminated albumin conjugate by imatinib: in rat hepatocellular carcinoma it is not preferentially higher than that in liver and bone marrow
    L Fiume
    Department of Experimental Pathology, University of Bologna, Italy
    Eur J Pharm Biopharm 72:630-1. 2009
    ..This observation casts some doubts about the possibility that the value of anticancer agents with toxic side effects on liver and bone marrow can be improved by imatinib...
  4. ncbi Doxorubicin coupled to lactosaminated human albumin: a hepatocellular carcinoma targeted drug
    Luigi Fiume
    Department of Experimental Pathology, University of Bologna, Italy
    Drug Discov Today 13:1002-9. 2008
    ..Unexpectedly, it was found that the conjugate enhanced DOXO concentrations in all forms of HCCs, independently of their differentiation grade...
  5. ncbi Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine
    Luigi Fiume
    Department of Experimental Pathology, University of Bologna, Via San Giacomo, 14 40126 Bologna, Italy
    J Hepatol 43:645-52. 2005
    ....
  6. ncbi Doxorubicin coupled to lactosaminated albumin: Effects on rats with liver fibrosis and cirrhosis
    G Di Stefano
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Dig Liver Dis 38:404-8. 2006
    ..However, coupled doxorubicin also accumulates in the liver, which might damage hepatocytes...
  7. ncbi Efficacy of doxorubicin coupled to lactosaminated albumin on rat hepatocellular carcinomas evaluated by ultrasound imaging
    G Di Stefano
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Dig Liver Dis 40:278-84. 2008
    ..The aim of the present study was to investigate the effects of lactosaminated human albumin coupled doxorubicin on the growth of established rat hepatocellular carcinomas induced by diethylnitrosamine...
  8. ncbi Coupling of 5-fluoro 2'-deoxyuridine to lactosaminated poly-l-lysine: an approach to a regional, non-invasive chemotherapy of liver micrometastases
    G Di Stefano
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126, Bologna, Italy
    Biochem Pharmacol 61:459-65. 2001
    ..The drug released from hepatic cells into liver blood following conjugate administration via the peripheral venous route might accomplish a locoregional, non-invasive treatment of micrometastases nourished by liver sinusoids...
  9. ncbi Floxuridine coupling with lactosaminated human albumin to increase drug efficacy on liver micrometastases
    G Di Stefano
    Department of Experimental Pathology, University of Bologna, Italy
    Dig Liver Dis 34:439-46. 2002
    ..After intracellular release from the carrier, the drugs partly exit from hepatic cells into hepatic blood...
  10. ncbi Doxorubicin coupled to lactosaminated human albumin remains confined within mouse liver cells after the intracellular release from the carrier
    G Di Stefano
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Dig Liver Dis 35:428-33. 2003
    ..The hepatocyte receptor for asialoglycoproteins, which binds and internalises galactosyl terminating peptides, was found to be expressed also on the cells of the majority of hepatocarcinomas...
  11. ncbi Inhibition of hepatitis B virus replication by vidarabine monophosphate conjugated with lactosaminated serum albumin
    L Fiume
    Department of Experimental Pathology, University of Bologna, Italy
    Lancet 2:13-5. 1988
    ..No antibodies (IgM and IgG classes) that bound the conjugate were detected. Thus L-HSA-ara-AMP inhibits HBV replication as well as free ara-AMP but at a third to a sixth of the dose...
  12. doi Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways
    F Farabegoli
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Eur J Pharm Sci 47:729-38. 2012
    ....