S Fiorucci

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. ncbi request reprint NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokines
    S Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, 06100 Perugia, Italy
    Am J Physiol Gastrointest Liver Physiol 281:G654-65. 2001
  2. ncbi request reprint The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis
    Stefano Fiorucci
    Dipartimento di Medicina Clinica, Patologia, Clinica di Gastroenterologia ed Endoscopia Digestiva, University of Perugia, Perugia, Italy
    Hepatology 42:539-48. 2005
  3. pmc Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis
    Barbara Renga
    Dipartimento di Medicina Clinica e Sperimentale, Nuova Facoltà di Medicina e Chirurgia, Universita di Perugia, S Andrea delle Fratte, Perugia, Italy
    PLoS ONE 7:e30443. 2012
  4. pmc VSL#3 resets insulin signaling and protects against NASH and atherosclerosis in a model of genetic dyslipidemia and intestinal inflammation
    Andrea Mencarelli
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facolta di Medicina e Chirurgia, Perugia, Italy
    PLoS ONE 7:e45425. 2012
  5. pmc The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice
    Andrea Mencarelli
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facolta di Medicina e Chirurgia, Perugia, Italy
    PLoS ONE 5:e13238. 2010
  6. pmc Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation
    Andrea Mencarelli
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facolta di Medicina e Chirurgia, Via Gerardo Dottori n 1 S Andrea delle Fratte, Perugia, Italy
    PLoS ONE 6:e22978. 2011
  7. pmc The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes
    Barbara Renga
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Perugia, Italy
    PLoS ONE 7:e35924. 2012
  8. pmc The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis
    Sabrina Cipriani
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    PLoS ONE 6:e25637. 2011
  9. pmc The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation
    Barbara Renga
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    PLoS ONE 8:e54472. 2013
  10. pmc HIV-1 infection is associated with changes in nuclear receptor transcriptome, pro-inflammatory and lipid profile of monocytes
    Barbara Renga
    Department of Experimental and Clinical Medicine, University of Perugia, Perugia, Italy
    BMC Infect Dis 12:274. 2012

Detail Information

Publications74

  1. ncbi request reprint NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokines
    S Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, 06100 Perugia, Italy
    Am J Physiol Gastrointest Liver Physiol 281:G654-65. 2001
    ..These data suggest that caspase S-nitrosation represents a mechanism for protection of colonic mucosal epithelial cells from death factor-induced death...
  2. ncbi request reprint The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis
    Stefano Fiorucci
    Dipartimento di Medicina Clinica, Patologia, Clinica di Gastroenterologia ed Endoscopia Digestiva, University of Perugia, Perugia, Italy
    Hepatology 42:539-48. 2005
    ..The reduction of CSE expression in the liver with cirrhosis contributes to the development of increased intrahepatic resistance and portal hypertension...
  3. pmc Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis
    Barbara Renga
    Dipartimento di Medicina Clinica e Sperimentale, Nuova Facoltà di Medicina e Chirurgia, Universita di Perugia, S Andrea delle Fratte, Perugia, Italy
    PLoS ONE 7:e30443. 2012
    ..Theonellasterol is a 4-methylene-24-ethylsteroid isolated from the marine sponge Theonella swinhoei. Here, we have characterized the activity of this theonellasterol on FXR-regulated genes and biological functions...
  4. pmc VSL#3 resets insulin signaling and protects against NASH and atherosclerosis in a model of genetic dyslipidemia and intestinal inflammation
    Andrea Mencarelli
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facolta di Medicina e Chirurgia, Perugia, Italy
    PLoS ONE 7:e45425. 2012
    ..The intestinal microbiota contributes to instructing the immune system beyond the intestinal wall and its modulation is a potential target for treating systemic disorders...
  5. pmc The bile acid sensor FXR protects against dyslipidemia and aortic plaques development induced by the HIV protease inhibitor ritonavir in mice
    Andrea Mencarelli
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facolta di Medicina e Chirurgia, Perugia, Italy
    PLoS ONE 5:e13238. 2010
    ..Here we illustrate that targeting the bile acid sensor farnesoid X receptor (FXR) protects against dyslipidemia and vascular injury induced HIV-PIs in rodents...
  6. pmc Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation
    Andrea Mencarelli
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facolta di Medicina e Chirurgia, Via Gerardo Dottori n 1 S Andrea delle Fratte, Perugia, Italy
    PLoS ONE 6:e22978. 2011
    ....
  7. pmc The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes
    Barbara Renga
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Perugia, Italy
    PLoS ONE 7:e35924. 2012
    ..A sustained immune activation supports lipid dysmetabolism and increased risk for development of accelerated atehrosclerosis and ischemic complication in virologically suppressed HIV-infected persons receiving HAART...
  8. pmc The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis
    Sabrina Cipriani
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    PLoS ONE 6:e25637. 2011
    ..In monocytes, ligation of GP-BAR1 by secondary bile acids results in a cAMP-dependent attenuation of cytokine generation...
  9. pmc The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation
    Barbara Renga
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    PLoS ONE 8:e54472. 2013
    ..Farnesoid X Receptor (FXR) is a nuclear receptor and bile acid sensor highly expressed in entero-hepatic tissues. FXR regulates lipid metabolism and innate immunity...
  10. pmc HIV-1 infection is associated with changes in nuclear receptor transcriptome, pro-inflammatory and lipid profile of monocytes
    Barbara Renga
    Department of Experimental and Clinical Medicine, University of Perugia, Perugia, Italy
    BMC Infect Dis 12:274. 2012
    ..The objective of the present study was to investigate for the relative abundance of members of the nuclear receptor family in monocytic cells isolated from HIV positive patients treated or not treated with HAART...
  11. doi request reprint Marine sponge steroids as nuclear receptor ligands
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Nuova Facoltà di Medicina e Chirurgia, 06132 Perugia, Italy
    Trends Pharmacol Sci 33:591-601. 2012
    ..These findings pave the way to the development of novel FXR and PXR agonists and antagonists to target human diseases...
  12. doi request reprint Farnesoid X receptor: from medicinal chemistry to clinical applications
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    Future Med Chem 4:877-91. 2012
    ..e., FXR agonists that selectively activate specific subsets of FXR target genes in a tissue) or co-regulator-specific manner...
  13. pmc Activation of the farnesoid-X receptor protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs in mice
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Via E dal Pozzo, Perugia, Italy
    Br J Pharmacol 164:1929-38. 2011
    ....
  14. ncbi request reprint Development of FXR, PXR and CAR agonists and antagonists for treatment of liver disorders
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, 06100 Perugia, Italy
    Curr Top Med Chem 12:605-24. 2012
    ..In addition, development of tissue specific FXR antagonists is an attractive opportunity to target subsets of genes in the intestine and liver avoiding sideeffects linked to FXR activation...
  15. pmc Hydrogen sulphide induces micro opioid receptor-dependent analgesia in a rodent model of visceral pain
    Eleonora Distrutti
    S C di Gastroenterologia, Azienda Ospedaliera di Perugia, Perugia, Italia
    Mol Pain 6:36. 2010
    ..A body of evidence support the notion that KATP channels interact with endogenous opioids. Whether H2S-induced analgesia involves opioid receptors is unknown...
  16. ncbi request reprint Targeting farnesoid X receptor for liver and metabolic disorders
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Perugia, Italy
    Trends Mol Med 13:298-309. 2007
    ..Interaction of FXR with other BAs and xenobiotics sensors such as the constitutive androstane receptor and the pregnane X receptor might allow the development of combination therapies for liver and metabolic disorders...
  17. ncbi request reprint Cyclo-oxygenase (COX) inhibiting nitric oxide donating (CINODs) drugs: a review of their current status
    Fiorucci Stefano
    Dipartimento di Medicina Clinica e Sperimentale, Policlinico Monteluce, Via E dal Pozzo, 06100 Perugia, Italy
    Curr Top Med Chem 7:277-82. 2007
    ..Recent clinical trials with CINODs (previously termed NO-NSAIDs) have provided data consistent with pre-clinical observations...
  18. ncbi request reprint NO-NSAIDs: from inflammatory mediators to clinical readouts
    Stefano Fiorucci
    University of Perugia, Italy
    Inflamm Allergy Drug Targets 5:121-31. 2006
    ..Recent clinical trials with NO-NSAIDs have provided data consistent with pre-clinical observations...
  19. ncbi request reprint Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs
    Stefano Fiorucci
    Dipartimento di Medicina Clinica, Patologia, Clinica di Gastroenterologia ed Endoscopia Digestiva, University of Perugia, Italy
    Gastroenterology 129:1210-24. 2005
    ..Here, we have investigated the role of H(2)S in a rodent model of nonsteroidal anti-inflammatory drug (NSAID) gastropathy...
  20. ncbi request reprint Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis
    Stefano Fiorucci
    Gastroenterologia ed Epatologia, Policlinico Monteluce, Perugia, Italy
    J Pharmacol Exp Ther 313:604-12. 2005
    ..In conclusion, by demonstrating that 6-ECDCA protects against E(2)17alpha cholestasis, our data support the notion that development of potent FXR ligands might represent a new approach for the treatment of cholestatic disorders...
  21. ncbi request reprint Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis
    Stefano Fiorucci
    Dipartimento de Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Italy
    J Pharmacol Exp Ther 315:58-68. 2005
    ..A FXR-PPARgamma cascade exerts counter-regulatory effects in HSCs activation...
  22. ncbi request reprint Dual COX-inhibitors: the answer is NO?
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Italy
    Curr Top Med Chem 5:487-92. 2005
    ..Animal studies have shown that CINOD and NO-aspirins maintain gastric mucosal blood flow and reduce leukocyte-endothelial cell adherence...
  23. ncbi request reprint A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis
    Stefano Fiorucci
    Dept of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via E dal Pozzo, 06122 Perugia, Italy
    J Pharmacol Exp Ther 314:584-95. 2005
    ..By demonstrating that a FXR-SHP regulatory cascade promotes the development of a quiescent phenotype and increases apoptosis of HSCs, this study establishes that FXR ligands may be beneficial in treatment of liver fibrosis...
  24. ncbi request reprint The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Endoscopia Digestiva, Perugia, Italy
    Gastroenterology 127:1497-512. 2004
    ..The aim of this study was to investigate whether FXR is expressed by and modulates function of hepatic stellate cells (HSCs)...
  25. ncbi request reprint NSAIDs, coxibs, CINOD and H2S-releasing NSAIDs: what lies beyond the horizon
    S Fiorucci
    Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Dig Liver Dis 39:1043-51. 2007
    ....
  26. doi request reprint Farnesoid X receptor agonists in biliary tract disease
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Italy
    Curr Opin Gastroenterol 25:252-9. 2009
    ....
  27. ncbi request reprint COXIBs, CINODs and H₂S-releasing NSAIDs: current perspectives in the development of safer non steroidal anti-inflammatory drugs
    S Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Via E dal Pozzo, 06122 Perugia, Italy
    Curr Med Chem 18:3494-505. 2011
    ..The beneficial role these mechanisms in clinical settings await a proof-of-concept study...
  28. ncbi request reprint Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCA
    S Fiorucci
    University of Perugia, Dipartimento di Medicina Clinica e Sperimentale, Nuova Facoltà di Medicina e Chirurgia, Via Gerardo Dottori n 1 S Andrea delle Fratte, 06132 Perugia, Italy
    Mini Rev Med Chem 11:753-62. 2011
    ..These side effects on bile acids and lipid metabolism were all predicted by pre-clinical studies, suggesting that potent FXR ligands hold promise but potential side effects might limit their development...
  29. ncbi request reprint Hydrogen sulfide-based therapies: focus on H2S releasing NSAIDs
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Via E dal Pozzo, 06122 Perugia, Italy
    Inflamm Allergy Drug Targets 10:133-40. 2011
    ..Either naproxen or diclofenac coupled to an H(2)S releasing moiety has been reported to cause less gastrointestinal and cardiovascular injury than parent NSAIDs in preclinical models...
  30. ncbi request reprint Hydrogen sulfide: from physiology to pharmacology
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, E dal Pozzo, 06122 Perugia, Italy
    Inflamm Allergy Drug Targets 10:77-84. 2011
    ..The anti-inflammatory activity of H(2)S has also been exploited for generating anti-platelets and anti-inflammatory agents that inhibit cyclo-oxygenases while sparing the gastrointestinal and cardiovascular tract...
  31. ncbi request reprint Counter-regulatory role of bile acid activated receptors in immunity and inflammation
    S Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, 06122 Perugia, Italy
    Curr Mol Med 10:579-95. 2010
    ..The ability of these receptors to integrate metabolic and inflammatory signaling makes them particularly attractive targets for intervention in immune-mediated diseases...
  32. ncbi request reprint Targetting farnesoid-X-receptor: from medicinal chemistry to disease treatment
    Stefano Fiorucci
    Universita di Perugia, Dipartimento di Medicina Clinica e Sperimentale, Via E dal Pozzo, 06122 Perugia, Italy
    Curr Med Chem 17:139-59. 2010
    ..Generation of modulators that selectively target specific FXRalpha responsive elements are an interesting strategy to overcome the limitations of currently available FXR ligands...
  33. doi request reprint Bile acid-activated receptors in the treatment of dyslipidemia and related disorders
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    Prog Lipid Res 49:171-85. 2010
    ..Ligands for these receptors hold promise in the treatment of dyslipidemic conditions as revealed by results of a number of preclinical models but carry a defined risk for potential side effects...
  34. doi request reprint Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    Trends Pharmacol Sci 30:570-80. 2009
    ..The development of dual FXR and TGR5 ligands could provide new opportunities for the treatment of lipid and glucose disorders...
  35. doi request reprint The plant sterol guggulsterone attenuates inflammation and immune dysfunction in murine models of inflammatory bowel disease
    Andrea Mencarelli
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Via E dal Pozzo, Perugia, Italy
    Biochem Pharmacol 78:1214-23. 2009
    ..These data ground the use of GS, a natural cholesterol-lowering agent, in the treatment of chronic inflammatory diseases...
  36. doi request reprint Prevention of nonsteroidal anti-inflammatory drug-induced ulcer: looking to the future
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Via E dal Pozzo, 06122 Perugia, Italy
    Gastroenterol Clin North Am 38:315-32. 2009
    ..The quest for the development of NSAIDs devoid of cardiovascular toxicity and that spare the gastric mucosa to the same extent as that of a coxib, however, is still open...
  37. pmc Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, Italy
    Br J Pharmacol 143:33-42. 2004
    ..7. In conclusion, NCX-1000 is effective in protecting against APAP-induced hepatotoxicity when administered in a therapeutic manner. This protection may involve the inhibition of apoptosis and the maintenance of mitochondrial integrity...
  38. ncbi request reprint Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NO
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Endoscopia Digestiva, Policlinico Monteluce, 06100 Perugia, Italy
    J Pharmacol Exp Ther 311:1264-71. 2004
    ..These data suggest that HCT-3012 might be a safer alternative to nonsteroidal anti-inflammatory drugs and coxibs in rheumatic patients that take low doses of ASA...
  39. pmc NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Endoscopia Digestiva, Dipartimento di Medicina Clinica, Patologia Università di Perugia, Italy
    Proc Natl Acad Sci U S A 99:15770-5. 2002
    ..In vivo treatment with NCX-1015 potently stimulated IL-10 production, suggesting that the NO steroid induces a regulatory subset of T cells that negatively modulates intestinal inflammation...
  40. ncbi request reprint NCX-4016, a nitric oxide-releasing aspirin, protects endothelial cells against apoptosis by modulating mitochondrial function
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, 06122 Perugia, Italy
    FASEB J 16:1645-7. 2002
    ..In contrast to DETA-NO, NCX-4016 did not increase mitochondrial oxidative stress. These data demonstrated that NCX-4016 conveys NO directly inside endothelial cells and modulates mitochondrial function...
  41. pmc A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, Italy
    Br J Pharmacol 135:589-99. 2002
    ..Collectively, these observations suggest that APAP toxicity is Fas mediated and that NCX-701 spares the liver by acting at several checkpoints in the Fas pathway...
  42. ncbi request reprint Mechanism of non-steroidal anti-inflammatory drug-gastropathy
    S Fiorucci
    University of Perugia, Italy
    Dig Liver Dis 33:S35-43. 2001
    ....
  43. ncbi request reprint Cyclo-oxygenase isoenzymes. Structural basis for selective inhibition of cyclo-oxygenases by anti-inflammatory agents
    S Fiorucci
    University of Perugia, Italy
    Dig Liver Dis 33:S2-7. 2001
    ..Both cyclo-oxygenase isoenzymes contribute to mucosal defence and the inhibition of the two isoforms contributes to the pathogenesis of non-steroidal anti-inflammatory drug-induced gastric damage...
  44. pmc Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis
    S Fiorucci
    Clinica di Gastroenterologia ed Endoscopia Digestiva, Dipartimento di Medicina Clinica, Patologia Univesita di Perugia, Perugia 06122, Italy
    Proc Natl Acad Sci U S A 98:13936-41. 2001
    ..Collectively, these studies show that PAR-2 is an anti-inflammatory receptor in the colon and suggest that PAR-2 ligands might be effective in the treatment of inflammatory bowel diseases...
  45. ncbi request reprint Nitric oxide-releasing NSAIDs: a review of their current status
    S Fiorucci
    Clinica di Gastroenterologia ed Epatologia Dipartimento di Medicina Clinica, e Sperimentale, Universita degli Studi di Perugia, Italy
    Drug Saf 24:801-11. 2001
    ..The GI toxicity of NO-flurbiprofen and NO-naproxen is currently being investigated in healthy individuals...
  46. pmc NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension
    S Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, 06122 Perugia, Italy
    Proc Natl Acad Sci U S A 98:8897-902. 2001
    ..In aggregate these data indicate that NCX-1000, releasing NO into the liver microcirculation, may provide a novel therapy for the treatment of patients with portal hypertension...
  47. pmc An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity
    S Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, 06122 Perugia, Italy
    Proc Natl Acad Sci U S A 98:2652-7. 2001
    ..Collectively, these data suggest that NCX-1000 protects against T helper 1-mediated liver injury by inhibiting both the proapoptotic and the proinflammatory branches of the caspase superfamily...
  48. ncbi request reprint IL-1 beta converting enzyme is a target for nitric oxide-releasing aspirin: new insights in the antiinflammatory mechanism of nitric oxide-releasing nonsteroidal antiinflammatory drugs
    S Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia
    J Immunol 165:5245-54. 2000
    ..Caspase-1 inhibition is a new, cycloxygenase-independent antiinflammatory mechanism of NO-aspirin...
  49. ncbi request reprint NO-releasing NSAIDs are caspase inhibitors
    S Fiorucci
    Clinica di Gastroenterologia ed Endoscopia Digestiva, Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, 06100 Perugia, Italy
    Trends Immunol 22:232-5. 2001
    ..This effect is largely owing to post-translational nitrosation and therefore inactivation of cysteine proteases, such as the interleukin (IL)-1beta converting enzyme (ICE/caspase-1) involved in pro-cytokine processing...
  50. ncbi request reprint Inhibition of intestinal bacterial translocation with rifaximin modulates lamina propria monocytic cells reactivity and protects against inflammation in a rodent model of colitis
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica, Sperimentale e Farmacologia, Universita di Perugia, Perugia, Italy
    Digestion 66:246-56. 2002
    ..Rifaximin, a non-absorbable derivative of rifamycin, is an effective antibiotic that acts by inhibiting bacterial ribonucleic acid synthesis...
  51. ncbi request reprint Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic study
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Perugia, Italy
    Gastroenterology 124:600-7. 2003
    ..NCX-4016 is a nitric oxide-releasing derivative of aspirin with antiplatelet activity. The aim of this study was to investigate the effect of NCX-4016 on gastrointestinal mucosa and platelet functions in healthy human volunteers...
  52. ncbi request reprint Nitric oxide regulates immune cell bioenergetic: a mechanism to understand immunomodulatory functions of nitric oxide-releasing anti-inflammatory drugs
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, Perugia, Italy
    J Immunol 173:874-82. 2004
    ....
  53. ncbi request reprint Treatment of portal hypertension with NCX-1000, a liver-specific NO donor. A review of its current status
    Stefano Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, Via E dal Pozzo, 06122, Perugia, Italy
    Cardiovasc Drug Rev 22:135-46. 2004
    ..In summary, these data suggest that NCX-1000 may provide a novel therapy for the treatment of patients with portal hypertension...
  54. ncbi request reprint PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation
    Stefano Fiorucci
    Dipartimento di Medicina Clinica, Patologia, Clinica di Gastroenterologia ed Endoscopia Digestiva, University of Perugia, Perugia
    Hepatology 39:365-75. 2004
    ..In conclusion, PAR(s) regulates HSC activity; development of PAR antagonists might be a feasible therapeutic strategy for protecting against fibrosis in patients with chronic liver diseases...
  55. ncbi request reprint Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(Acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester (NCX-4016) (NO-aspirin) on neutrophil-endothelial cell adherence
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Endoscopia Digestiva, Policlinico Monteluce, 06100 Perugia, Italy
    J Pharmacol Exp Ther 309:1174-82. 2004
    ..In summary, our results support that ATL and NO are formed at the PMN/HUVEC interface after exposure to NCX-4016 and mediate the antiadhesive properties of this compound...
  56. ncbi request reprint NCX-1000, a nitric oxide-releasing derivative of ursodeoxycholic acid, ameliorates portal hypertension and lowers norepinephrine-induced intrahepatic resistance in the isolated and perfused rat liver
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    J Hepatol 39:932-9. 2003
    ....
  57. pmc Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Italy
    Proc Natl Acad Sci U S A 100:10937-41. 2003
    ....
  58. pmc Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    Br J Pharmacol 139:1351-9. 2003
    ....
  59. ncbi request reprint PAR-2 modulates pepsinogen secretion from gastric-isolated chief cells
    Stefano Fiorucci
    Dipartimento di Medicina Clinica, Universita di Perugia, 06122 Perugia, Italy
    Am J Physiol Gastrointest Liver Physiol 285:G611-20. 2003
    ..Collectively, these data indicate that PAR-2 is expressed on gastric chief cells and that its activation causes a Ca2+-ERK-dependent stimulation of pepsinogen secretion...
  60. ncbi request reprint Nitric oxide and portal hypertension: a nitric oxide-releasing derivative of ursodeoxycholic acid that selectively releases nitric oxide in the liver
    S Fiorucci
    Gastrointestinal and Liver Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Dig Liver Dis 35:S61-9. 2003
    ..Administration of NCX1000 to portal hypertensive rats decreases intrahepatic resistance providing a novel therapy for the treatment of portal hypertension...
  61. ncbi request reprint NO-aspirin: mechanism of action and gastrointestinal safety
    S Fiorucci
    Gastrointestinal and Liver Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Dig Liver Dis 35:S9-19. 2003
    ..Further studies are ongoing to define whether this superior anti-inflammatory and anti-thrombotic profile translates in clinical benefits in patients with cardiovascular diseases...
  62. ncbi request reprint Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    FASEB J 17:1171-3. 2003
    ..These findings indicate that the balance between the production of LTB4 and ATL modulates PMN recruitment/function and gastric mucosal responses to aspirin...
  63. ncbi request reprint NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines
    S Fiorucci
    Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, Perugia, Italy
    Gastroenterology 118:404-21. 2000
    ..NCX-4016 is an NO-aspirin derivative that spares the gastrointestinal tract and shares molecular targets with NO. The aim of this study was to investigate whether this NO-aspirin modulates Th1-like response induced by con A...
  64. ncbi request reprint Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats
    S Fiorucci
    Sezione di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    Gastroenterology 116:1089-106. 1999
    ..The aim of this study was to investigate whether cysteine endoproteases are involved in the pathogenesis of NSAID gastropathy and are target for NO-aspirin (NCX-4016)...
  65. pmc Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis
    S Fiorucci
    Department of Gastroenterology, University of Perugia, Perugia, Italy
    Br J Pharmacol 150:996-1002. 2007
    ..The purpose of this study was to determine if an H(2)S-releasing derivative of mesalamine (ATB-429) would exhibit increased potency and effectiveness in a mouse model of colitis...
  66. ncbi request reprint Galectin-1 exerts immunomodulatory and protective effects on concanavalin A-induced hepatitis in mice
    L Santucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    Hepatology 31:399-406. 2000
    ..The present study suggests that galectin-1 is potentially useful in the treatment of T-cell-mediated human liver disorders...
  67. doi request reprint FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicity
    A Mencarelli
    Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facolta di Medicina e Chirurgia, Via Gerardo Dottori n 1, S Andrea delle Fratte, 06132 Perugia, Italy
    Nutr Metab Cardiovasc Dis 23:94-101. 2013
    ..In the present study we have investigated whether administering obese (fa/fa) Zucker rats, a genetic model of obesity associated with dyslipidemia and insulin resistance, with an FXR ligand protects against lipid-induced cardiomyopathy...
  68. ncbi request reprint Salicylates inhibit T cell adhesion on endothelium under nonstatic conditions: induction of L-selectin shedding by a tyrosine kinase-dependent mechanism
    R Gerli
    Section of Internal Medicine, Center for the Study of Rheumatic Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    J Immunol 166:832-40. 2001
    ..These results suggest that salicylates interfere not only with integrin activation, but also with the L-selectin-mediated first steps of T cell binding to endothelium...
  69. ncbi request reprint Pathogenesis of non-steroidal anti-inflammatory drug gastropathy
    S Fiorucci
    Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Ital J Gastroenterol Hepatol 31:S6-13. 1999
    ....
  70. ncbi request reprint Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy?
    S Fiorucci
    Sezione di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Università delgi Studi di Perugia, Via E A del Pozzo, Perugia, Italy
    Biochem Pharmacol 62:1433-8. 2001
    ..This new approach will certainly help to unravel the mechanisms at the root of the undesirable effects of NSAIDs and to develop safer NSAIDs...
  71. pmc Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice
    A Mencacci
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy
    Infect Immun 68:5126-31. 2000
    ....
  72. ncbi request reprint Effect of acute and chronic levosulpiride administration on gastric tone and perception in functional dyspepsia
    E Distrutti
    Gastroenterology Unit, University of Perugia, GiEnne Pharma, Milano, Italy
    Aliment Pharmacol Ther 16:613-22. 2002
    ..Altered visceral perception is common in functional dyspepsia (FD). Dopaminergic pathways control gastrointestinal motility, but whether they modulate visceral sensitivity is unknown...
  73. pmc In vivo activated T cells in rheumatoid synovitis. Analysis of Th1- and Th2-type cytokine production at clonal level in different stages of disease
    R Gerli
    Department of Clinical and Experimental Medicine, Section of Internal Medicine and Oncologic Sciences, Rheumatology Unit, University of Perugia, Italy
    Clin Exp Immunol 129:549-55. 2002
    ..The synthesis of both cytokines is a feature of the very early phase of RA, although the selective recruitment of IL-10-producing T cells is quickly lost...
  74. pmc Molecular characterization of inherited carnitine palmitoyltransferase II deficiency
    F Taroni
    Divisione di Biochimica e Genetica, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy
    Proc Natl Acad Sci U S A 89:8429-33. 1992
    ..Biochemical characterization of mutant CPTase II in patient's cells showed that the mutations are associated with (i) severe reduction of Vmax (approximately 90%), (ii) normal apparent Km values, and (iii) decreased protein stability...