Research Topics
| S FiorucciSummaryAffiliation: University of Perugia Country: Italy Publications
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Detail Information
Publications
NO-mesalamine protects colonic epithelial cells against apoptotic damage induced by proinflammatory cytokinesS Fiorucci
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, 06100 Perugia, Italy
Am J Physiol Gastrointest Liver Physiol 281:G654-65. 2001..These data suggest that caspase S-nitrosation represents a mechanism for protection of colonic mucosal epithelial cells from death factor-induced death...
Marine sponge steroids as nuclear receptor ligandsStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Nuova Facoltà di Medicina e Chirurgia, 06132 Perugia, Italy
Trends Pharmacol Sci 33:591-601. 2012..These findings pave the way to the development of novel FXR and PXR agonists and antagonists to target human diseases...- Farnesoid X receptor: from medicinal chemistry to clinical applicationsStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
Future Med Chem 4:877-91. 2012..e., FXR agonists that selectively activate specific subsets of FXR target genes in a tissue) or co-regulator-specific manner... 
Activation of the farnesoid-X receptor protects against gastrointestinal injury caused by non-steroidal anti-inflammatory drugs in miceStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Via E dal Pozzo, Perugia, Italy
Br J Pharmacol 164:1929-38. 2011....- Development of FXR, PXR and CAR agonists and antagonists for treatment of liver disordersStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, 06100 Perugia, Italy
Curr Top Med Chem 12:605-24. 2012..In addition, development of tissue specific FXR antagonists is an attractive opportunity to target subsets of genes in the intestine and liver avoiding sideeffects linked to FXR activation... - Hydrogen sulphide induces micro opioid receptor-dependent analgesia in a rodent model of visceral painEleonora Distrutti
S C di Gastroenterologia, Azienda Ospedaliera di Perugia, Perugia, Italia
Mol Pain 6:36. 2010..A body of evidence support the notion that KATP channels interact with endogenous opioids. Whether H2S-induced analgesia involves opioid receptors is unknown... - Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugsStefano Fiorucci
Dipartimento di Medicina Clinica, Patologia, Clinica di Gastroenterologia ed Endoscopia Digestiva, University of Perugia, Italy
Gastroenterology 129:1210-24. 2005..Here, we have investigated the role of H(2)S in a rodent model of nonsteroidal anti-inflammatory drug (NSAID) gastropathy... - The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosisStefano Fiorucci
Dipartimento di Medicina Clinica, Patologia, Clinica di Gastroenterologia ed Endoscopia Digestiva, University of Perugia, Perugia, Italy
Hepatology 42:539-48. 2005..The reduction of CSE expression in the liver with cirrhosis contributes to the development of increased intrahepatic resistance and portal hypertension... - Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosisStefano Fiorucci
Dipartimento de Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Italy
J Pharmacol Exp Ther 315:58-68. 2005..A FXR-PPARgamma cascade exerts counter-regulatory effects in HSCs activation... - Dual COX-inhibitors: the answer is NO?Stefano Fiorucci
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Italy
Curr Top Med Chem 5:487-92. 2005..Animal studies have shown that CINOD and NO-aspirins maintain gastric mucosal blood flow and reduce leukocyte-endothelial cell adherence... - A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosisStefano Fiorucci
Dept of Clinical and Experimental Medicine, University of Perugia, Policlinico Monteluce, Via E dal Pozzo, 06122 Perugia, Italy
J Pharmacol Exp Ther 314:584-95. 2005..By demonstrating that a FXR-SHP regulatory cascade promotes the development of a quiescent phenotype and increases apoptosis of HSCs, this study establishes that FXR ligands may be beneficial in treatment of liver fibrosis... - Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasisStefano Fiorucci
Gastroenterologia ed Epatologia, Policlinico Monteluce, Perugia, Italy
J Pharmacol Exp Ther 313:604-12. 2005..In conclusion, by demonstrating that 6-ECDCA protects against E(2)17alpha cholestasis, our data support the notion that development of potent FXR ligands might represent a new approach for the treatment of cholestatic disorders... - Farnesoid X receptor agonists in biliary tract diseaseStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Italy
Curr Opin Gastroenterol 25:252-9. 2009.... - The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosisStefano Fiorucci
Clinica di Gastroenterologia ed Endoscopia Digestiva, Perugia, Italy
Gastroenterology 127:1497-512. 2004..The aim of this study was to investigate whether FXR is expressed by and modulates function of hepatic stellate cells (HSCs)... - Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in miceStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, Italy
Br J Pharmacol 143:33-42. 2004..7. In conclusion, NCX-1000 is effective in protecting against APAP-induced hepatotoxicity when administered in a therapeutic manner. This protection may involve the inhibition of apoptosis and the maintenance of mitochondrial integrity... - Nitric oxide (NO)-releasing naproxen (HCT-3012 [(S)-6-methoxy-alpha-methyl-2-naphthaleneacetic Acid 4-(nitrooxy)butyl ester]) interactions with aspirin in gastric mucosa of arthritic rats reveal a role for aspirin-triggered lipoxin, prostaglandins, and NOStefano Fiorucci
Clinica di Gastroenterologia ed Endoscopia Digestiva, Policlinico Monteluce, 06100 Perugia, Italy
J Pharmacol Exp Ther 311:1264-71. 2004..These data suggest that HCT-3012 might be a safer alternative to nonsteroidal anti-inflammatory drugs and coxibs in rheumatic patients that take low doses of ASA... - Nitric oxide regulates immune cell bioenergetic: a mechanism to understand immunomodulatory functions of nitric oxide-releasing anti-inflammatory drugsStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, Perugia, Italy
J Immunol 173:874-82. 2004.... - Treatment of portal hypertension with NCX-1000, a liver-specific NO donor. A review of its current statusStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, Via E dal Pozzo, 06122, Perugia, Italy
Cardiovasc Drug Rev 22:135-46. 2004..In summary, these data suggest that NCX-1000 may provide a novel therapy for the treatment of patients with portal hypertension... - NO-NSAIDs: from inflammatory mediators to clinical readoutsStefano Fiorucci
University of Perugia, Italy
Inflamm Allergy Drug Targets 5:121-31. 2006..Recent clinical trials with NO-NSAIDs have provided data consistent with pre-clinical observations... - Cyclo-oxygenase (COX) inhibiting nitric oxide donating (CINODs) drugs: a review of their current statusFiorucci Stefano
Dipartimento di Medicina Clinica e Sperimentale, Policlinico Monteluce, Via E dal Pozzo, 06100 Perugia, Italy
Curr Top Med Chem 7:277-82. 2007..Recent clinical trials with CINODs (previously termed NO-NSAIDs) have provided data consistent with pre-clinical observations... - Targeting farnesoid X receptor for liver and metabolic disordersStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Perugia, Italy
Trends Mol Med 13:298-309. 2007..Interaction of FXR with other BAs and xenobiotics sensors such as the constitutive androstane receptor and the pregnane X receptor might allow the development of combination therapies for liver and metabolic disorders... - COXIBs, CINODs and H₂S-releasing NSAIDs: current perspectives in the development of safer non steroidal anti-inflammatory drugsS Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Via E dal Pozzo, 06122 Perugia, Italy
Curr Med Chem 18:3494-505. 2011..The beneficial role these mechanisms in clinical settings await a proof-of-concept study... - Farnesoid X receptor agonist for the treatment of liver and metabolic disorders: focus on 6-ethyl-CDCAS Fiorucci
University of Perugia, Dipartimento di Medicina Clinica e Sperimentale, Nuova Facoltà di Medicina e Chirurgia, Via Gerardo Dottori n 1 S Andrea delle Fratte, 06132 Perugia, Italy
Mini Rev Med Chem 11:753-62. 2011..These side effects on bile acids and lipid metabolism were all predicted by pre-clinical studies, suggesting that potent FXR ligands hold promise but potential side effects might limit their development... - Hydrogen sulfide-based therapies: focus on H2S releasing NSAIDsStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Via E dal Pozzo, 06122 Perugia, Italy
Inflamm Allergy Drug Targets 10:133-40. 2011..Either naproxen or diclofenac coupled to an H(2)S releasing moiety has been reported to cause less gastrointestinal and cardiovascular injury than parent NSAIDs in preclinical models... - Hydrogen sulfide: from physiology to pharmacologyStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, E dal Pozzo, 06122 Perugia, Italy
Inflamm Allergy Drug Targets 10:77-84. 2011..The anti-inflammatory activity of H(2)S has also been exploited for generating anti-platelets and anti-inflammatory agents that inhibit cyclo-oxygenases while sparing the gastrointestinal and cardiovascular tract... - Counter-regulatory role of bile acid activated receptors in immunity and inflammationS Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, 06122 Perugia, Italy
Curr Mol Med 10:579-95. 2010..The ability of these receptors to integrate metabolic and inflammatory signaling makes them particularly attractive targets for intervention in immune-mediated diseases... - Targetting farnesoid-X-receptor: from medicinal chemistry to disease treatmentStefano Fiorucci
Universita di Perugia, Dipartimento di Medicina Clinica e Sperimentale, Via E dal Pozzo, 06122 Perugia, Italy
Curr Med Chem 17:139-59. 2010..Generation of modulators that selectively target specific FXRalpha responsive elements are an interesting strategy to overcome the limitations of currently available FXR ligands... - Bile acid-activated receptors in the treatment of dyslipidemia and related disordersStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
Prog Lipid Res 49:171-85. 2010..Ligands for these receptors hold promise in the treatment of dyslipidemic conditions as revealed by results of a number of preclinical models but carry a defined risk for potential side effects... - Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disordersStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
Trends Pharmacol Sci 30:570-80. 2009..The development of dual FXR and TGR5 ligands could provide new opportunities for the treatment of lipid and glucose disorders... - The plant sterol guggulsterone attenuates inflammation and immune dysfunction in murine models of inflammatory bowel diseaseAndrea Mencarelli
Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Via E dal Pozzo, Perugia, Italy
Biochem Pharmacol 78:1214-23. 2009..These data ground the use of GS, a natural cholesterol-lowering agent, in the treatment of chronic inflammatory diseases... - Prevention of nonsteroidal anti-inflammatory drug-induced ulcer: looking to the futureStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Via E dal Pozzo, 06122 Perugia, Italy
Gastroenterol Clin North Am 38:315-32. 2009..The quest for the development of NSAIDs devoid of cardiovascular toxicity and that spare the gastric mucosa to the same extent as that of a coxib, however, is still open... - NSAIDs, coxibs, CINOD and H2S-releasing NSAIDs: what lies beyond the horizonS Fiorucci
Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
Dig Liver Dis 39:1043-51. 2007.... - PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activationStefano Fiorucci
Dipartimento di Medicina Clinica, Patologia, Clinica di Gastroenterologia ed Endoscopia Digestiva, University of Perugia, Perugia
Hepatology 39:365-75. 2004..In conclusion, PAR(s) regulates HSC activity; development of PAR antagonists might be a feasible therapeutic strategy for protecting against fibrosis in patients with chronic liver diseases... - Cooperation between aspirin-triggered lipoxin and nitric oxide (NO) mediates antiadhesive properties of 2-(Acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl ester (NCX-4016) (NO-aspirin) on neutrophil-endothelial cell adherenceStefano Fiorucci
Clinica di Gastroenterologia ed Endoscopia Digestiva, Policlinico Monteluce, 06100 Perugia, Italy
J Pharmacol Exp Ther 309:1174-82. 2004..In summary, our results support that ATL and NO are formed at the PMN/HUVEC interface after exposure to NCX-4016 and mediate the antiadhesive properties of this compound... - A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathwayStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, Italy
Br J Pharmacol 135:589-99. 2002..Collectively, these observations suggest that APAP toxicity is Fas mediated and that NCX-701 spares the liver by acting at several checkpoints in the Fas pathway... - Cyclo-oxygenase isoenzymes. Structural basis for selective inhibition of cyclo-oxygenases by anti-inflammatory agentsS Fiorucci
University of Perugia, Italy
Dig Liver Dis 33:S2-7. 2001..Both cyclo-oxygenase isoenzymes contribute to mucosal defence and the inhibition of the two isoforms contributes to the pathogenesis of non-steroidal anti-inflammatory drug-induced gastric damage... - Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitisS Fiorucci
Clinica di Gastroenterologia ed Endoscopia Digestiva, Dipartimento di Medicina Clinica, Patologia Univesita di Perugia, Perugia 06122, Italy
Proc Natl Acad Sci U S A 98:13936-41. 2001..Collectively, these studies show that PAR-2 is an anti-inflammatory receptor in the colon and suggest that PAR-2 ligands might be effective in the treatment of inflammatory bowel diseases... - Nitric oxide-releasing NSAIDs: a review of their current statusS Fiorucci
Clinica di Gastroenterologia ed Epatologia Dipartimento di Medicina Clinica, e Sperimentale, Universita degli Studi di Perugia, Italy
Drug Saf 24:801-11. 2001..The GI toxicity of NO-flurbiprofen and NO-naproxen is currently being investigated in healthy individuals... - NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertensionS Fiorucci
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, 06122 Perugia, Italy
Proc Natl Acad Sci U S A 98:8897-902. 2001..In aggregate these data indicate that NCX-1000, releasing NO into the liver microcirculation, may provide a novel therapy for the treatment of patients with portal hypertension... - NO-releasing NSAIDs are caspase inhibitorsS Fiorucci
Clinica di Gastroenterologia ed Endoscopia Digestiva, Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, 06100 Perugia, Italy
Trends Immunol 22:232-5. 2001..This effect is largely owing to post-translational nitrosation and therefore inactivation of cysteine proteases, such as the interleukin (IL)-1beta converting enzyme (ICE/caspase-1) involved in pro-cytokine processing... - An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activityS Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, 06122 Perugia, Italy
Proc Natl Acad Sci U S A 98:2652-7. 2001..Collectively, these data suggest that NCX-1000 protects against T helper 1-mediated liver injury by inhibiting both the proapoptotic and the proinflammatory branches of the caspase superfamily... - IL-1 beta converting enzyme is a target for nitric oxide-releasing aspirin: new insights in the antiinflammatory mechanism of nitric oxide-releasing nonsteroidal antiinflammatory drugsS Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia
J Immunol 165:5245-54. 2000..Caspase-1 inhibition is a new, cycloxygenase-independent antiinflammatory mechanism of NO-aspirin... - NCX-4016, a nitric oxide-releasing aspirin, protects endothelial cells against apoptosis by modulating mitochondrial functionStefano Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, 06122 Perugia, Italy
FASEB J 16:1645-7. 2002..In contrast to DETA-NO, NCX-4016 did not increase mitochondrial oxidative stress. These data demonstrated that NCX-4016 conveys NO directly inside endothelial cells and modulates mitochondrial function... - NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in miceStefano Fiorucci
Clinica di Gastroenterologia ed Endoscopia Digestiva, Dipartimento di Medicina Clinica, Patologia Università di Perugia, Italy
Proc Natl Acad Sci U S A 99:15770-5. 2002..In vivo treatment with NCX-1015 potently stimulated IL-10 production, suggesting that the NO steroid induces a regulatory subset of T cells that negatively modulates intestinal inflammation... - NCX-1000, a nitric oxide-releasing derivative of ursodeoxycholic acid, ameliorates portal hypertension and lowers norepinephrine-induced intrahepatic resistance in the isolated and perfused rat liverStefano Fiorucci
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
J Hepatol 39:932-9. 2003.... - Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosaStefano Fiorucci
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Italy
Proc Natl Acad Sci U S A 100:10937-41. 2003.... - Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirinStefano Fiorucci
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
Br J Pharmacol 139:1351-9. 2003.... - Nitric oxide and portal hypertension: a nitric oxide-releasing derivative of ursodeoxycholic acid that selectively releases nitric oxide in the liverS Fiorucci
Gastrointestinal and Liver Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
Dig Liver Dis 35:S61-9. 2003..Administration of NCX1000 to portal hypertensive rats decreases intrahepatic resistance providing a novel therapy for the treatment of portal hypertension... - NO-aspirin: mechanism of action and gastrointestinal safetyS Fiorucci
Gastrointestinal and Liver Unit, Department of Internal Medicine, University of Perugia, Perugia, Italy
Dig Liver Dis 35:S9-19. 2003..Further studies are ongoing to define whether this superior anti-inflammatory and anti-thrombotic profile translates in clinical benefits in patients with cardiovascular diseases... - PAR-2 modulates pepsinogen secretion from gastric-isolated chief cellsStefano Fiorucci
Dipartimento di Medicina Clinica, Universita di Perugia, 06122 Perugia, Italy
Am J Physiol Gastrointest Liver Physiol 285:G611-20. 2003..Collectively, these data indicate that PAR-2 is expressed on gastric chief cells and that its activation causes a Ca2+-ERK-dependent stimulation of pepsinogen secretion... - Relative contribution of acetylated cyclo-oxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirinStefano Fiorucci
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
FASEB J 17:1171-3. 2003..These findings indicate that the balance between the production of LTB4 and ATL modulates PMN recruitment/function and gastric mucosal responses to aspirin... - Mechanism of non-steroidal anti-inflammatory drug-gastropathyS Fiorucci
University of Perugia, Italy
Dig Liver Dis 33:S35-43. 2001.... - Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers: a proof of concept endoscopic studyStefano Fiorucci
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita di Perugia, Perugia, Italy
Gastroenterology 124:600-7. 2003..NCX-4016 is a nitric oxide-releasing derivative of aspirin with antiplatelet activity. The aim of this study was to investigate the effect of NCX-4016 on gastrointestinal mucosa and platelet functions in healthy human volunteers... - Inhibition of intestinal bacterial translocation with rifaximin modulates lamina propria monocytic cells reactivity and protects against inflammation in a rodent model of colitisStefano Fiorucci
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica, Sperimentale e Farmacologia, Universita di Perugia, Perugia, Italy
Digestion 66:246-56. 2002..Rifaximin, a non-absorbable derivative of rifamycin, is an effective antibiotic that acts by inhibiting bacterial ribonucleic acid synthesis... - NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokinesS Fiorucci
Dipartimento di Medicina Clinica e Sperimentale, Clinica di Gastroenterologia ed Epatologia, Universita degli Studi di Perugia, Perugia, Italy
Gastroenterology 118:404-21. 2000..NCX-4016 is an NO-aspirin derivative that spares the gastrointestinal tract and shares molecular targets with NO. The aim of this study was to investigate whether this NO-aspirin modulates Th1-like response induced by con A... - Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in ratsS Fiorucci
Sezione di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
Gastroenterology 116:1089-106. 1999..The aim of this study was to investigate whether cysteine endoproteases are involved in the pathogenesis of NSAID gastropathy and are target for NO-aspirin (NCX-4016)... - Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitisS Fiorucci
Department of Gastroenterology, University of Perugia, Perugia, Italy
Br J Pharmacol 150:996-1002. 2007..The purpose of this study was to determine if an H(2)S-releasing derivative of mesalamine (ATB-429) would exhibit increased potency and effectiveness in a mouse model of colitis... - Galectin-1 exerts immunomodulatory and protective effects on concanavalin A-induced hepatitis in miceL Santucci
Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
Hepatology 31:399-406. 2000..The present study suggests that galectin-1 is potentially useful in the treatment of T-cell-mediated human liver disorders... - Salicylates inhibit T cell adhesion on endothelium under nonstatic conditions: induction of L-selectin shedding by a tyrosine kinase-dependent mechanismR Gerli
Section of Internal Medicine, Center for the Study of Rheumatic Diseases, Department of Clinical and Experimental Medicine, University of Perugia, Italy
J Immunol 166:832-40. 2001..These results suggest that salicylates interfere not only with integrin activation, but also with the L-selectin-mediated first steps of T cell binding to endothelium... - Pathogenesis of non-steroidal anti-inflammatory drug gastropathyS Fiorucci
Department of Clinical and Experimental Medicine, University of Perugia, Italy
Ital J Gastroenterol Hepatol 31:S6-13. 1999.... - Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy?S Fiorucci
Sezione di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Università delgi Studi di Perugia, Via E A del Pozzo, Perugia, Italy
Biochem Pharmacol 62:1433-8. 2001..This new approach will certainly help to unravel the mechanisms at the root of the undesirable effects of NSAIDs and to develop safer NSAIDs... - FXR activation improves myocardial fatty acid metabolism in a rodent model of obesity-driven cardiotoxicityA Mencarelli
Dipartimento di Medicina Clinica e Sperimentale, University of Perugia, Facolta di Medicina e Chirurgia, Via Gerardo Dottori n 1, S Andrea delle Fratte, 06132 Perugia, Italy Electronic address
Nutr Metab Cardiovasc Dis 23:94-101. 2013..In the present study we have investigated whether administering obese (fa/fa) Zucker rats, a genetic model of obesity associated with dyslipidemia and insulin resistance, with an FXR ligand protects against lipid-induced cardiomyopathy... - Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient miceA Mencacci
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy
Infect Immun 68:5126-31. 2000.... - Effect of acute and chronic levosulpiride administration on gastric tone and perception in functional dyspepsiaE Distrutti
Gastroenterology Unit, University of Perugia, GiEnne Pharma, Milano, Italy
Aliment Pharmacol Ther 16:613-22. 2002..Altered visceral perception is common in functional dyspepsia (FD). Dopaminergic pathways control gastrointestinal motility, but whether they modulate visceral sensitivity is unknown... - In vivo activated T cells in rheumatoid synovitis. Analysis of Th1- and Th2-type cytokine production at clonal level in different stages of diseaseR Gerli
Department of Clinical and Experimental Medicine, Section of Internal Medicine and Oncologic Sciences, Rheumatology Unit, University of Perugia, Italy
Clin Exp Immunol 129:549-55. 2002..The synthesis of both cytokines is a feature of the very early phase of RA, although the selective recruitment of IL-10-producing T cells is quickly lost... - Molecular characterization of inherited carnitine palmitoyltransferase II deficiencyF Taroni
Divisione di Biochimica e Genetica, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy
Proc Natl Acad Sci U S A 89:8429-33. 1992..Biochemical characterization of mutant CPTase II in patient's cells showed that the mutations are associated with (i) severe reduction of Vmax (approximately 90%), (ii) normal apparent Km values, and (iii) decreased protein stability...