Chiara Fiorentini

Summary

Affiliation: University of Brescia
Country: Italy

Publications

  1. ncbi request reprint Receptor heteromers in Parkinson's disease and L-DOPA-induced dyskinesia
    Chiara Fiorentini
    Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    CNS Neurol Disord Drug Targets 12:1101-13. 2013
  2. doi request reprint Persistent activation of the D1R/Shp-2/Erk1/2 pathway in l-DOPA-induced dyskinesia in the 6-hydroxy-dopamine rat model of Parkinson's disease
    Chiara Fiorentini
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnology and National Institute of Neuroscience, Italy
    Neurobiol Dis 54:339-48. 2013
  3. doi request reprint The tyrosine phosphatase Shp-2 interacts with the dopamine D(1) receptor and triggers D(1) -mediated Erk signaling in striatal neurons
    Chiara Fiorentini
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnology and National Institute of Neuroscience, University of Brescia, Brescia, Italy
    J Neurochem 117:253-63. 2011
  4. ncbi request reprint Identification and characterization of two nuclear factor-kappaB sites in the regulatory region of the dopamine D2 receptor
    Sandra Bontempi
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa 11, 25124 Brescia, Italy
    Endocrinology 148:2563-70. 2007
  5. doi request reprint Role of receptor heterodimers in the development of L-dopa-induced dyskinesias in the 6-hydroxydopamine rat model of Parkinson's disease
    Chiara Fiorentini
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, Brescia, Italy
    Parkinsonism Relat Disord 14:S159-64. 2008
  6. ncbi request reprint Loss of synaptic D1 dopamine/N-methyl-D-aspartate glutamate receptor complexes in L-DOPA-induced dyskinesia in the rat
    Chiara Fiorentini
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, 25124 Brescia, Italy
    Mol Pharmacol 69:805-12. 2006
  7. ncbi request reprint Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization
    Chiara Fiorentini
    Section of Pharmacology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, 25124 Brescia, Italy
    Mol Pharmacol 74:59-69. 2008
  8. ncbi request reprint Nerve growth factor and retinoic acid interactions in the control of small cell lung cancer proliferation
    Chiara Fiorentini
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Via Valsabbina 19, 25124 Brescia, Italy
    Eur J Endocrinol 147:371-9. 2002
  9. ncbi request reprint GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity
    Chiara Fiorentini
    Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, V le Europa 11, 25124 Brescia, Italy
    Exp Cell Res 323:100-11. 2014
  10. doi request reprint Dimerization of dopamine D1 and D3 receptors in the regulation of striatal function
    Chiara Fiorentini
    Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Curr Opin Pharmacol 10:87-92. 2010

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Receptor heteromers in Parkinson's disease and L-DOPA-induced dyskinesia
    Chiara Fiorentini
    Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    CNS Neurol Disord Drug Targets 12:1101-13. 2013
    ....
  2. doi request reprint Persistent activation of the D1R/Shp-2/Erk1/2 pathway in l-DOPA-induced dyskinesia in the 6-hydroxy-dopamine rat model of Parkinson's disease
    Chiara Fiorentini
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnology and National Institute of Neuroscience, Italy
    Neurobiol Dis 54:339-48. 2013
    ....
  3. doi request reprint The tyrosine phosphatase Shp-2 interacts with the dopamine D(1) receptor and triggers D(1) -mediated Erk signaling in striatal neurons
    Chiara Fiorentini
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnology and National Institute of Neuroscience, University of Brescia, Brescia, Italy
    J Neurochem 117:253-63. 2011
    ....
  4. ncbi request reprint Identification and characterization of two nuclear factor-kappaB sites in the regulatory region of the dopamine D2 receptor
    Sandra Bontempi
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies, University of Brescia, Viale Europa 11, 25124 Brescia, Italy
    Endocrinology 148:2563-70. 2007
    ..A correlation was found between NF-kappaB activity and D2R expression in the pituitary and pituitary-derived cells but not in the striatum, suggesting that NF-kappaB regulation of D2R expression could be a pituitary-specific mechanism...
  5. doi request reprint Role of receptor heterodimers in the development of L-dopa-induced dyskinesias in the 6-hydroxydopamine rat model of Parkinson's disease
    Chiara Fiorentini
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, Brescia, Italy
    Parkinsonism Relat Disord 14:S159-64. 2008
    ..Using the 6-hydroxydopamine rat model of Parkinson's disease, we report a correlation between the development of L-dopa-induced dyskinesias and changes in synaptic D1R/NMDAR complexes...
  6. ncbi request reprint Loss of synaptic D1 dopamine/N-methyl-D-aspartate glutamate receptor complexes in L-DOPA-induced dyskinesia in the rat
    Chiara Fiorentini
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, 25124 Brescia, Italy
    Mol Pharmacol 69:805-12. 2006
    ....
  7. ncbi request reprint Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization
    Chiara Fiorentini
    Section of Pharmacology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, 25124 Brescia, Italy
    Mol Pharmacol 74:59-69. 2008
    ..These data give a novel insight into how D1R and D3R may function in an integrated way, providing a molecular mechanism by which to converge D1R- and D3R-related dysfunctions...
  8. ncbi request reprint Nerve growth factor and retinoic acid interactions in the control of small cell lung cancer proliferation
    Chiara Fiorentini
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Via Valsabbina 19, 25124 Brescia, Italy
    Eur J Endocrinol 147:371-9. 2002
    ..Since these effects are lost upon NGF withdrawal, it is relevant to identify other differentiation factors that may co-operate with the NGF system to control SCLC growth and differentiation...
  9. ncbi request reprint GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity
    Chiara Fiorentini
    Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, V le Europa 11, 25124 Brescia, Italy
    Exp Cell Res 323:100-11. 2014
    ..Together, these data reveal that GPNMB/OA acts as a critical molecular mediator promoting the acquisition of the more aggressive, pro-metastatic phenotype distinctive of human DU145 and PC3 cell lines. ..
  10. doi request reprint Dimerization of dopamine D1 and D3 receptors in the regulation of striatal function
    Chiara Fiorentini
    Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Curr Opin Pharmacol 10:87-92. 2010
    ..The putative role of the D1R-D3R heteromer in the development of motor dysfunctions is also discussed...
  11. doi request reprint Molecular and pharmacological detection of dopaminergic receptors in the human male urinary tract
    Nicola Arrighi
    Division of Urology, University of Brescia Medical School, p le Spedali Civili 1, Brescia, Italy
    Neurourol Urodyn 28:343-8. 2009
    ..Here, we studied the distribution of DA receptor subtypes in different parts of the human male urinary tract...
  12. ncbi request reprint Regulation of dopamine D1 receptor trafficking and desensitization by oligomerization with glutamate N-methyl-D-aspartate receptors
    Chiara Fiorentini
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnology, and the Centre of Excellence on Diagnostic and Therapeutic Innovation, University of Brescia, Viale Europa 11, Italy
    J Biol Chem 278:20196-202. 2003
    ....
  13. ncbi request reprint The NMDA/D1 receptor complex as a new target in drug development
    Cristina Missale
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnology, and Centre of Excellence on Diagnostic and Therapeutic Innovation, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Curr Top Med Chem 6:801-8. 2006
    ..In this paper we review the molecular mechanisms, functional implications and pharmacological significance of D1R/NMDAR interaction via direct protein-protein oligomerization...
  14. doi request reprint The neurobiology of dopamine receptors: evolution from the dual concept to heterodimer complexes
    Cristina Missale
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnologies and Italian Institute of Neurosceince, University of Brescia, Brescia, Italy
    J Recept Signal Transduct Res 30:347-54. 2010
    ..These heteromers have peculiar pharmacological, signaling, and trafficking properties. GPCR heteromerization, raising different combinatorial possibilities, thus underlies an unexpected level of diversity within this receptor family...
  15. ncbi request reprint The "in situ" proximity ligation assay to probe protein-protein interactions in intact tissues
    Arianna Bellucci
    Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123, Brescia, BS, Italy
    Methods Mol Biol 1174:397-405. 2014
    ..Here, we describe the use of "in situ" PLA to visualize the localization of protein-protein interactions in intact tissues. ..
  16. ncbi request reprint Nerve growth factor regulates dopamine D(2) receptor expression in prolactinoma cell lines via p75(NGFR)-mediated activation of nuclear factor-kappaB
    Chiara Fiorentini
    Division of Pharmacology, Department of Biomedical Sciences and Biotechnology, University of Brescia, 25123 Brescia, Italy
    Mol Endocrinol 16:353-66. 2002
    ..We thus suggest that NF-kappaB is a key transcriptional regulator of the D(2) gene and that this mechanism may not be confined to pituitary tumors, but could also extend to other dopaminergic systems...
  17. ncbi request reprint Kainate receptor RNA editing is markedly altered by acute spinal cord injury
    Luca Caracciolo
    Division of Biology and Genetics, Department of Molecular and Translational Medicine and National Institute of Neuroscience, University of Brescia, Viale Europa 11, 25123, Brescia, Italy
    J Mol Neurosci 51:903-10. 2013
    ..These findings add novel information to the relevance of editing of glutamate receptors following acute SCI, thus expanding the recently emerged role of post-transcriptional mechanisms under these experimental conditions...