N Ferri

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi Fibrillar collagen inhibits cholesterol biosynthesis in human aortic smooth muscle cells
    Nicola Ferri
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milano, Italy
    Arterioscler Thromb Vasc Biol 29:1631-7. 2009
  2. ncbi Drug attrition during pre-clinical and clinical development: Understanding and managing drug-induced cardiotoxicity
    Nicola Ferri
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Milan, Italy Electronic address
    Pharmacol Ther 138:470-84. 2013
  3. ncbi AMP-activated protein kinase and the control of smooth muscle cell hyperproliferation in vascular disease
    Nicola Ferri
    Department of Pharmacological Sciences, Via Balzaretti 9, 20133, Milan, Italy
    Vascul Pharmacol 56:9-13. 2012
  4. ncbi Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels
    Nicola Ferri
    Department of Pharmacological Sciences, University of Milan, 20133, Milan, Italy
    Atherosclerosis 220:381-6. 2012
  5. ncbi Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation
    Nicola Ferri
    Department of Pharmacological Sciences, University of Milan, Milano, Italy
    Arterioscler Thromb Vasc Biol 27:1043-9. 2007
  6. ncbi Virtual screening approach for the identification of new Rac1 inhibitors
    Nicola Ferri
    Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, 20133 Milano, Italy
    J Med Chem 52:4087-90. 2009
  7. ncbi Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation
    Nicola Ferri
    Department of Pharmacological Sciences, University of Milan, Milan 20133, Italy
    Biochem Pharmacol 70:1735-43. 2005
  8. ncbi Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/cyclin E expression
    N Ferri
    Department of Pharmacological Sciences, Via Balzaretti 9, 20133 Milan, Italy
    Mol Pharmacol 74:144-53. 2008
  9. ncbi Aliskiren reduces prorenin receptor expression and activity in cultured human aortic smooth muscle cells
    Nicola Ferri
    Department of Pharmacological Sciences, University of Milan, Italy
    J Renin Angiotensin Aldosterone Syst 12:469-74. 2011
  10. ncbi Isothiazoles. Part XV. A mild and efficient synthesis of new antiproliferative 5-sulfanylsubstituted 3-alkylaminoisothiazole 1,1-dioxides
    F Clerici
    Istituto di Chimica Organica A Marchesini, Facolta di Farmacia, Universita di Milano, via Venezian 21, 20133 Milano, Italy
    Eur J Med Chem 41:675-82. 2006

Collaborators

Detail Information

Publications25

  1. ncbi Fibrillar collagen inhibits cholesterol biosynthesis in human aortic smooth muscle cells
    Nicola Ferri
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milano, Italy
    Arterioscler Thromb Vasc Biol 29:1631-7. 2009
    ..In the present study, we examined the effect of type I fibrillar collagen on cholesterol biosynthesis in human aortic smooth muscle cells (SMCs)...
  2. ncbi Drug attrition during pre-clinical and clinical development: Understanding and managing drug-induced cardiotoxicity
    Nicola Ferri
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Milan, Italy Electronic address
    Pharmacol Ther 138:470-84. 2013
    ....
  3. ncbi AMP-activated protein kinase and the control of smooth muscle cell hyperproliferation in vascular disease
    Nicola Ferri
    Department of Pharmacological Sciences, Via Balzaretti 9, 20133, Milan, Italy
    Vascul Pharmacol 56:9-13. 2012
    ....
  4. ncbi Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels
    Nicola Ferri
    Department of Pharmacological Sciences, University of Milan, 20133, Milan, Italy
    Atherosclerosis 220:381-6. 2012
    ..Although PCSK9 is mainly of hepatic origin, extra-hepatic tissues significantly contribute to PCSK9 production and, potentially, local regulation of LDL receptor expression...
  5. ncbi Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation
    Nicola Ferri
    Department of Pharmacological Sciences, University of Milan, Milano, Italy
    Arterioscler Thromb Vasc Biol 27:1043-9. 2007
    ..The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been shown to interfere with integrin signaling, but their effects on collagen receptor-mediated MMP expression have not been investigated...
  6. ncbi Virtual screening approach for the identification of new Rac1 inhibitors
    Nicola Ferri
    Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, 20133 Milano, Italy
    J Med Chem 52:4087-90. 2009
    ..These compounds were shown to be more effective than the reference compound NSC23766 in reducing the intracellular levels of Rac1-GTP, thus supporting this approach for the development of new Rac1 inhibitors...
  7. ncbi Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation
    Nicola Ferri
    Department of Pharmacological Sciences, University of Milan, Milan 20133, Italy
    Biochem Pharmacol 70:1735-43. 2005
    ..Taken together, we described a new PFTase inhibitor containing the isothiazole dioxide moiety that affects mammalian protein farnesylation and SMC proliferation by inhibiting G0/G1 phase of the cell cycle...
  8. ncbi Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/cyclin E expression
    N Ferri
    Department of Pharmacological Sciences, Via Balzaretti 9, 20133 Milan, Italy
    Mol Pharmacol 74:144-53. 2008
    ....
  9. ncbi Aliskiren reduces prorenin receptor expression and activity in cultured human aortic smooth muscle cells
    Nicola Ferri
    Department of Pharmacological Sciences, University of Milan, Italy
    J Renin Angiotensin Aldosterone Syst 12:469-74. 2011
    ..The recent discovery of a specific receptor for renin/prorenin (PRR) has added new interest to the potential pharmacological actions of aliskiren, the first direct renin inhibitor...
  10. ncbi Isothiazoles. Part XV. A mild and efficient synthesis of new antiproliferative 5-sulfanylsubstituted 3-alkylaminoisothiazole 1,1-dioxides
    F Clerici
    Istituto di Chimica Organica A Marchesini, Facolta di Farmacia, Universita di Milano, via Venezian 21, 20133 Milano, Italy
    Eur J Med Chem 41:675-82. 2006
    ..On the contrary, the 3-amino-4,5-unsubstituted isothiazole dioxide system reacts easily only with sulfur nucleophiles affording the corresponding 4,5-dihydro-5-sulfanylderivatives through a simple Michael addition reaction...
  11. ncbi Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation
    N Ferri
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Biochem Pharmacol 62:1637-45. 2001
    ..We provide evidence that S(-) PA affects protein prenylation, an effect that may contribute to its inhibition of SMC proliferation...
  12. ncbi Lipid-modified proteins as biomarkers for cardiovascular disease: a review
    N Ferri
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Biomarkers 10:219-37. 2005
    ..This review will briefly summarize the different enzymatic pathways of lipid modification and propose a series of lipid-modified proteins that can be used as biomarkers for cardiovascular disease...
  13. ncbi [Pharmacological control of biosynthesis pathway of mevalonate: effect on the proliferation of arterial smooth muscle cells]
    A Corsini
    Institut des Sciences Pharmacologiques, Université de Milan, Italie
    C R Seances Soc Biol Fil 191:169-94. 1997
    ..Taken together, these findings support the involvement of specific isoprenoid metabolites, probably through farnesylated and geranylgeranylated proteins in cell proliferation...
  14. ncbi Are pleiotropic effects of statins real?
    Alberto Corsini
    Department of Pharmacological Sciences, Luigi Sacco University of Milan, Milano, Italy
    Vasc Health Risk Manag 3:611-3. 2007
    ..Therefore, acute coronary syndromes could represent a clinical condition for addressing the early benefits of statins therapy, ie, within 24 h of the event, independent of LDL-C lowering...
  15. ncbi Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) by 15-lipoxygenase-modified LDL in endothelial cells
    Angela Pirillo
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Atherosclerosis 214:331-7. 2011
    ..Lectin-like oxidized LDL receptor-1 (LOX-1), the endothelial receptor for OxLDL, is believed to be responsible for a number of OxLDL-induced effects in the endothelium...
  16. ncbi Everolimus inhibits monocyte/macrophage migration in vitro and their accumulation in carotid lesions of cholesterol-fed rabbits
    Roberta Baetta
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Pharmacol Exp Ther 328:419-25. 2009
    ..These results suggest that everolimus may favorably influence the atherosclerotic process by affecting the recruitment of monocytes into early lesions...
  17. ncbi New Ras CAAX mimetics: design, synthesis, antiproliferative activity, and RAS prenylation inhibition
    Cristiano Bolchi
    Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Universita degli Studi di Milano, Via Mangiagalli 25, I 20133 Milano, Italy
    Bioorg Med Chem Lett 19:5500-4. 2009
    ..Of these compounds, the one with terminal methionine and S configuration proved a good Ras prenylation inhibitor in a cell-based assay...
  18. ncbi Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype
    Sara Pellegrino
    DISMAB Dipartimento di Scienze Molecolari Applicate ai Biosistemi Sez Chimica Organica, Universita degli Studi di Milano, I 20133 Milan, Italy
    Bioorg Med Chem Lett 19:6298-302. 2009
    ..In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of alpha-actin and decreased Id protein levels...
  19. ncbi Antiproliferative effects on human tumor cells and rat aortic smooth muscular cells of 2,3-heteroarylmaleimides and heterofused imides
    Nicola Ferri
    Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
    Bioorg Med Chem 16:1691-701. 2008
    ..Instead 12c is equipotent to amonafide. These results suggest that the extended pi-system and the kind of heteroatom are essential in the binding with the molecular target...
  20. ncbi Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation
    Nicola Ferri
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Br J Pharmacol 138:811-8. 2003
    ..6) Altogether, our results provide evidence that ajoene interferes with the protein prenylation reaction, an effect that may contribute to its inhibition of SMC proliferation...
  21. ncbi Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis
    Nicola Ferri
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA
    Am J Pathol 164:1575-85. 2004
    ..Taken together, these data provide evidence for the potential roles of DDR1 and DDR2 in the regulation of collagen turnover mediated by SMCs in obstructive diseases of blood vessels and the lung...
  22. ncbi Integrin-mediated transcriptional activation of inhibitor of apoptosis proteins protects smooth muscle cells against apoptosis induced by degraded collagen
    Karin von Wnuck Lipinski
    Institute of Pathophysiology, Center of Internal Medicine, University Hospital, Essen, Germany
    Circ Res 98:1490-7. 2006
    ..This may constitute a novel antiapoptotic pathway ensuring SMC survival in settings of enhanced ECM degradation such as cell migration, vascular remodeling, and atherosclerotic plaque rupture...
  23. ncbi Peptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency
    Cristiano Bolchi
    Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, Universita di Milano, Via Mangiagalli 25, Milan, Italy
    Bioorg Med Chem Lett 17:6192-6. 2007
    ..The docking analysis enlightened significant differences in enzyme interaction between oxymethylpyridodioxane and aminomethylpyridodioxane derivatives...
  24. ncbi An NF-kappaB-dependent transcriptional program is required for collagen remodeling by human smooth muscle cells
    Nicola Ferri
    Department of Pathology, University of Washington School of Medicine, Seattle 98104, USA
    J Biol Chem 278:19757-64. 2003
    ..Thus, polymerized collagen induces NF-kappaB-dependent expression of MMP1 and alpha2beta1 integrin, that are required for smooth muscle extracellular matrix remodeling...
  25. ncbi Efficient expression of exogenous genes in primary vascular cells using IRES-based retroviral vectors
    Kyle J Garton
    University of Washington School of Medicine, Seattle, USA
    Biotechniques 32:830, 832, 834 passim. 2002
    ..Potential applications of retroviral expression strategies in vascular biology are also discussed...