Research Topics
Genomes and GenesSpecies | Clodoveo FerriSummaryAffiliation: University of Pisa Country: Italy Publications
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Publications
Parvovirus B19 infection of bone marrow in systemic sclerosis patientsC Ferri
Rheumatology Unit, Department of Internal Medicine, University of Pisa, Italy
Clin Exp Rheumatol 17:718-20. 1999..To investigate the prevalence of human parvovirus B19 (B19) infection in the bone marrow of systemic sclerosis (SSc) patients...- HCV and cryoglobulinemic vasculitisC Ferri
Dipartimento di Medicina Interna, Reumatologia, , Italy
Cleve Clin J Med 69:SII20-3. 2002 - Systemic sclerosis: demographic, clinical, and serologic features and survival in 1,012 Italian patientsClodoveo Ferri
Rheumatology Unit, Department of Internal Medicine, University of Pisa, Italy
Medicine (Baltimore) 81:139-53. 2002 
CryoglobulinsC Ferri
Dipartimento di Medicina Interna, Universita di Pisa, Pisa 56126, Italy
J Clin Pathol 55:4-13. 2002..Chronic HCV infection can lead to a constellation of autoimmune and neoplastic disorders. In this review, the aetiology, diagnosis, disease heterogeneity, and treatment of cryoglobulinaemia are discussed...- Isolated pulmonary hypertension in diffuse cutaneous systemic sclerosis successfully treated with long-term plasma exchangeC Ferri
Department of Internal Medicine, University of Pisa, Italy
Scand J Rheumatol 29:198-200. 2000..This beneficial effect persisted for two years, even after plasma exchange discontinuation. This is the first observation of isolated PHT in dSSc responsive to plasma exchange therapy... - Relation between infection and autoimmunity in mixed cryoglobulinemiaC Ferri
Dipartimento Medicina Interna, Rheumatology Unit, University of Pisa, Italy
Curr Opin Rheumatol 12:53-60. 2000.... 
CXCL10 and CCL2 chemokine serum levels in patients with hepatitis C associated with autoimmune thyroiditisAlessandro Antonelli
Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
J Interferon Cytokine Res 29:345-51. 2009....- Th1 and Th2 chemokine serum levels in systemic sclerosis in the presence or absence of autoimmune thyroiditisAlessandro Antonelli
Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
J Rheumatol 35:1809-11. 2008..We evaluated contemporarily serum alpha and beta chemokines in patients with newly diagnosed systemic sclerosis (SSc) in the presence or absence of autoimmune thyroiditis (AT)... - High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infectionAlessandro Antonelli
Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
Am J Gastroenterol 103:2488-94. 2008.... - Clinical and subclinical autoimmune thyroid disorders in systemic sclerosisAlessandro Antonelli
Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
Eur J Endocrinol 156:431-7. 2007..Several studies have reported the association of systemic sclerosis (SSc) with thyroid autoimmune disorders, but most of them have neither an appropriate control group nor include a complete thyroid work-up... - N-terminal pro-brain natriuretic peptide and tumor necrosis factor-alpha both are increased in patients with Hepatitis CAlessandro Antonelli
Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
J Interferon Cytokine Res 30:359-63. 2010..The increase of NT-proBNP may indicate the presence of a subclinical cardiac dysfunction. Further prospective studies quantifying symptoms and correlating these with echocardiographic parameters are needed to confirm this association... - High circulating N-terminal pro-brain natriuretic peptide and tumor necrosis factor-alpha in mixed cryoglobulinemiaAlessandro Antonelli
Department of Internal Medicine, University of Pisa, School of Medicine, Pisa, 56100 Italy
World J Gastroenterol 15:5074-9. 2009..To evaluate serum levels of N-terminal pro-brain natriuretic peptide (NTproBNP) and tumor necrosis factor alpha (TNF-alpha) in a large series of patients with hepatitis C associated with mixed cryoglobulinemia (MC+HCV)... - The presence of autoimmune thyroiditis in mixed cryoglobulinemia patients is associated with high levels of circulating interleukin-6, but not of tumor necrosis factor-alphaAlessandro Antonelli
Department of Internal Medicine, University of Pisa, Italy
Clin Exp Rheumatol 29:S17-22. 2011..The aims of the study were to evaluate serum levels of IL-6 in MC+HCV patients and to correlate this parameter with the presence of AT and with circulating levels of TNF-α... - Serum levels of proinflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor alpha in mixed cryoglobulinemiaAlessandro Antonelli
Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
Arthritis Rheum 60:3841-7. 2009..This study was undertaken to evaluate serum levels of these cytokines in patients with HCV-MC... - High serum levels of CXCL11 in mixed cryoglobulinemia are associated with increased circulating levels of interferon-γAlessandro Antonelli
Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
J Rheumatol 38:1947-52. 2011..We measured CXCL11, and correlated this measurement to the clinical phenotype... - High levels of circulating chemokine (C-X-C motif) ligand 11 are associated with euthyroid or subclinically hypothyroid autoimmune thyroiditis and with chemokine (C-X-C motif) ligand 10Alessandro Antonelli
Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
J Interferon Cytokine Res 32:74-80. 2012..These results underline the importance of a Th1 immune attack in the initiation of AT... - Thyroid cancer in HCV-related chronic hepatitis patients: a case-control studyAlessandro Antonelli
Metabolism Unit Department of Internal Medicine, University of Pisa, Italy
Thyroid 17:447-51. 2007.... - Serum concentrations of interleukin 1beta, CXCL10, and interferon-gamma in mixed cryoglobulinemia associated with hepatitis C infectionAlessandro Antonelli
Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, I 56100, Pisa, Italy
J Rheumatol 37:91-7. 2010..We evaluated serum levels of IL-1beta, IFN-gamma, and CXCL10 in a series of patients with hepatitis C-related MC (MC+HCV), and correlated these measurements with clinical disease features... - High values of CXCL10 serum levels in patients with hepatitis C associated mixed cryoglobulinemia in presence or absence of autoimmune thyroiditisAlessandro Antonelli
Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, I 56100 Pisa, Italy
Cytokine 42:137-43. 2008..0001). In conclusion, our study is the first to demonstrate high serum levels of CXCL10 in MC and that CXCL10 in MC+AT patients are significantly higher compared to MC patients... - High interleukin-6 and tumor necrosis factor-alpha serum levels in hepatitis C infection associated or not with mixed cryoglobulinemiaAlessandro Antonelli
Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma, 67, 56100, Pisa, Italy
Clin Rheumatol 28:1179-85. 2009..01). The study demonstrates high IL-6 and TNF-a serum levels in HCV-MC patients; moreover, IL-6 levels tended to be higher in HCV-MC patients in presence of active vasculitis... - Circulating CXCL11 and CXCL10 are increased in hepatitis C-associated cryoglobulinemia in the presence of autoimmune thyroiditisAlessandro Antonelli
Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma, 67, 56100 Pisa, Italy
Mod Rheumatol 22:659-67. 2012..The aim of the present study, therefore, was to evaluate serum CXCL11 levels in these patients... - Cytokines and HCV-related disordersPoupak Fallahi
Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
Clin Dev Immunol 2012:468107. 2012..The therapeutical administration of cytokines such as IFN-alpha may result in viral clearance during persistent infection and reverts this process... - Thyroid disorders in chronic hepatitis C virus infectionAlessandro Antonelli
Department of Internal Medicine, University of Pisa, Pisa, Italy
Thyroid 16:563-72. 2006..The abovementioned evidences seem sufficient to suggest careful thyroid monitoring during the follow-up of patients with HCV infection... - Immunopathogenesis of HCV-related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemiaAlessandro Antonelli
Metabolism Unit, Department of Internal Medicine, University of Pisa, Italy
Autoimmun Rev 8:18-23. 2008..This process may lead to the appearance of thyroid autoimmune disorders or T2D in genetically predisposed subjects... - High circulating levels of N-terminal pro-brain natriuretic peptide and interleukin 6 in patients with mixed cryoglobulinemiaAlessandro Antonelli
Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
J Med Virol 82:297-303. 2010..07). The study revealed high levels of circulating NTproBNP and IL-6 in patients with mixed cryoglobulinemia and chronic HCV infection. The increase in NTproBNP could indicate the presence of a subclinical cardiac dysfunction... - Interleukin-1β, C-x-C motif ligand 10, and interferon-gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroiditisAlessandro Antonelli
Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
J Interferon Cytokine Res 30:835-42. 2010..Moreover, a pathophysiological association between high circulating levels of IL-1β and CXCL10 has been suggested. A possible therapeutic role of the anti-IL-1 receptor antagonist (Anakirna) in MC remains to be evaluated... - Alpha-chemokine CXCL10 and beta-chemokine CCL2 serum levels in patients with hepatitis C-associated cryoglobulinemia in the presence or absence of autoimmune thyroiditisAlessandro Antonelli
Department of Internal Medicine, University of Pisa School of Medicine, I 56100 Pisa, Italy
Metabolism 57:1270-7. 2008..Future studies in larger series will be needed to evaluate the potential usefulness of serum CXCL10 and CCL2 determination as a prognostic marker in the follow-up of MC patients, also in relation to the presence of AT... - B-cells and mixed cryoglobulinemiaClodoveo Ferri
Chair and Rheumatology Unit, Department of Internal Medicine, University of Modena and Reggio E, Medical School, Modena, Italy
Autoimmun Rev 7:114-20. 2007..The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients... - Interferon-α, -β and -γ induce CXCL11 secretion in human thyrocytes: Modulation by peroxisome proliferator-activated receptor γ agonistsAlessandro Antonelli
Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma 67, 56100 Pisa, Italy Electronic address
Immunobiology 218:690-5. 2013..Furthermore, PPAR-γ activation partially inhibits this process... - Endocrine manifestations of hepatitis C virus infectionAlessandro Antonelli
Department of Internal Medicine, University of Pisa, Pisa, Italy
Nat Clin Pract Endocrinol Metab 5:26-34. 2009..Nonetheless, additional studies will be necessary to elucidate fully all the mechanisms involved in HCV-related endocrine dysfunction... - Systemic sclerosis fibroblasts show specific alterations of interferon-γ and tumor necrosis factor-α-induced modulation of interleukin 6 and chemokine ligand 2Alessandro Antonelli
Department of Internal Medicine, Metabolism Unit, University of Pisa School of Medicine, Pisa, Italy
J Rheumatol 39:979-85. 2012.... - RET TKI: potential role in thyroid cancersAlessandro Antonelli
Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma 67, 56100 Pisa, Italy
Curr Oncol Rep 14:97-104. 2012..The aim of the introduction of these targeted therapies is to extend life duration assuring a good quality of life; however, further studies are needed to reach these goals... - Mixed cryoglobulinemia: demographic, clinical, and serologic features and survival in 231 patientsClodoveo Ferri
Department of Internal Medicine, University of Pisa Medical School, Pisa, Italy
Semin Arthritis Rheum 33:355-74. 2004..MC is characterized by multiple organ involvement, mainly skin, liver, renal, peripheral nerves, and less frequently by widespread vasculitis and cancer... - Hepatitis C virus-related lymphoproliferative disorders: an overviewAnna Linda Zignego
Department of Internal Medicine, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
World J Gastroenterol 13:2467-78. 2007..Available pathogenetic hypotheses and suggestions about the most appropriate, currently available, therapeutic approaches will also be discussed... - Platelet gel in the treatment of severe scleroderma skin ulcersDilia Giuggioli
Rheumatology Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, Italy
Rheumatol Int 32:2929-32. 2012..08 ± 13.5 to 57.9 ± 12.6; p < 0.0001 and HAQ from 0.73 ± 0.43 to 0.57 ± 0.22; p < 0.0001. PG may represent a novel therapeutic option for SSc skin ulcers refractory to conventional treatments... - Current treatment of hepatitis C-associated rheumatic diseasesClodoveo Ferri
Rheumatology Unit, University of Modena and Reggio Emilia School of Medicine, 41100 Modena, Italy
Arthritis Res Ther 14:215. 2012..The therapeutic approach to these disorders should be decided according to each individual patient's evaluation, including hepatic, virological, and immunological findings... - New targeted molecular therapies for dedifferentiated thyroid cancerAlessandro Antonelli
Department of Internal Medicine, Metabolism Unit, University of Pisa School of Medicine, Via Roma, 67, 56100 Pisa, Italy
J Oncol 2010:921682. 2010..Progress is being made toward effective targeted DeTC therapy. The possibility of testing the sensitivity of primary DeTC cells from each subject to different TKIs could increase the effectiveness of the treatment... - Bronchoalveolar lavage and response to cyclophosphamide in scleroderma alveolitisM Colaci
Rheumatology Unit, University of Modena and Reggio Emilia Medical School, Modena Polyclinic, Modena, Italy
Scand J Rheumatol 39:155-9. 2010..Our study aimed to evaluate whether the normalization of BAL cellularity correlates with long-term response to CYC... - [Extrahepatic manifestations of hepatitis C virus: the thyroid disorders]Alessandro Antonelli
Dipartimento di Medicina Interna, Universita di Pisa
Recenti Prog Med 96:370-81. 2005..These last data need to be confirmed by other studies, but seem to be sufficient to suggest careful thyroid monitoring during the follow-up of patients with HCV infection... - Cryoglobulinemic vasculitisClodoveo Ferri
Chair and Rheumatology Unit, Department of Internal Medicine, University of Modena e Reggio Emilia, Medical School, Modena, Italy
Curr Opin Rheumatol 18:54-63. 2006..A causative role of hepatitis C virus in over 80% patients has been definitively established, with heterogeneous geographical distribution. This review focuses on recent etiopathogenetic, clinico-diagnostic, and therapeutical studies... - Lung cancer in scleroderma: results from an Italian rheumatologic center and review of the literatureMichele Colaci
Rheumatology Unit, University of Modena and Reggio Emilia, Modena, Italy
Autoimmun Rev 12:374-9. 2013..Our study confirmed the higher frequency of lung cancer among SSc patients compared to general population, particularly within patients' subset with serum anti-Scl70 antibodies and lung involvement... - Efficacy and safety of peginterferon alfa-2b plus ribavirin for HCV-positive mixed cryoglobulinemia: a multicentre open-label studyCesare Mazzaro
Department of Internal Medicine, Pordenone General Hospital, Pordenone, Italy
Clin Exp Rheumatol 29:933-41. 2011..The aim of the present study is to provide information on clinical outcome of the patients affected by HCV-positive mixed cryoglobulinemia (MC) treated with PEG-IFN and Ribavirin for 6 or 12 months according to the HCV genotype... - Staphylococcus protein A-based extracorporeal immunoadsorption and thalidomide in the treatment of skin manifestation of dermatomyositis: a case reportMarco Sebastiani
Department of Internal Medicine, University of Modena and Reggio Emilia, Via del Pozzo 71, Modena, Italy
Ther Apher Dial 13:225-8. 2009..If confirmed, the observed beneficial effects suggest that protein A-based immunoadsorption and thalidomide can represent an alternative option in dermatomyositis, especially when cutaneous manifestations are predominant... - L-Arginine in pregnant scleroderma patientsDilia Giuggioli
Rheumatology Unit, University of Modena and Reggio Emilia, Modena, Italy
Clin Rheumatol 29:937-9. 2010..The neonate had severe respiratory distress syndrome complicated by severe infection and died at day 28. Although limited, our pilot study suggests that L-arginine may be a useful therapeutic agent in pregnant SSc women... - Thyroid disorders in chronic hepatitis CAlessandro Antonelli
Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
Am J Med 117:10-3. 2004..To explore the association of hepatitis C virus (HCV) infection with thyroid disorders... - Hepatitis C virus infection: evidence for an association with type 2 diabetesAlessandro Antonelli
Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, School of Medicine, Via Roma, 67, I-56100, Pisa, Italy
Diabetes Care 28:2548-50. 2005 - Patient preferences in the choice of anti-TNF therapies in rheumatoid arthritis. Results from a questionnaire survey (RIVIERA study)Salvatore Scarpato
Rheumatology Unit, M Scarlato Hospital, Scafati, 5, Via Passanti, 84018 Scafati SA, Italy
Rheumatology (Oxford) 49:289-94. 2010..To identify the determinants of anti-TNF-naive patients' preferences for the route of administration of anti-TNF agents... - Oxycodone in the long-term treatment of chronic pain related to scleroderma skin ulcersDilia Giuggioli
Department of Internal Medicine, University of Modena e Reggio Emilia, Medical School, Modena, Italy
Pain Med 11:1500-3. 2010..To demonstrate the efficacy and safety of long-term therapy with oxycodone in severe pain of scleroderma skin ulcers... - Epstein-barr virus reactivation after infliximab in rheumatoid arthritis: a case reportMichele Colaci
Rheumatology Unit, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, Italy
Case Rep Infect Dis 2011:530568. 2011..We describe the case of a patient who developed a symptomatic EBV reactivation 11 days after the first infusion of infliximab... - Etanercept maintains the clinical benefit achieved by infliximab in patients with rheumatoid arthritis who discontinued infliximab because of side effectsFlorenzo Iannone
Department of Internal Medicine and Public Medicine, Rheumatology Unit, University of Bari, Bari, Italy
Ann Rheum Dis 66:249-52. 2007..To evaluate the efficacy of switching to etanercept treatment in patients with rheumatoid arthritis who already responded to infliximab, but presented side effects... - Prevalence of bcl-2 rearrangement in patients with hepatitis C virus-related mixed cryoglobulinemia with or without B-cell lymphomasAnna Linda Zignego
Department of Internal Medicine, University of Florence, School of Medicine, Viale Morgagni, 85, 50134 Florence, Italy
Ann Intern Med 137:571-80. 2002..An increased prevalence of bcl-2 rearrangement (the t(14;18) translocation) has been shown in patients infected with HCV... - Systemic sclerosis in childhood: clinical and immunologic features of 153 patients in an international databaseGiorgia Martini
University of Padua, Padua, Italy
Arthritis Rheum 54:3971-8. 2006..Juvenile SSc appears to be less severe than in adults because children have less internal organ involvement, a less specific autoantibody profile, and a better long-term outcome... - Role of the HLA class II: HCV-related disordersValli De Re
CRO IRCCS, Aviano National Cancer Institute, Pordenone, Italy
Ann N Y Acad Sci 1107:308-18. 2007.... - Incidence and characteristics of non-Hodgkin lymphomas in a multicenter case file of patients with hepatitis C virus-related symptomatic mixed cryoglobulinemiasGiuseppe Monti
, Saronno Hospital, Italy
Arch Intern Med 165:101-5. 2005..The presence of CS did not significantly affect the treatment of newly diagnosed lymphomas... - Erectile dysfunction and hepatitis C virus infectionClodoveo Ferri
JAMA 288:698-9. 2002 - Good clinical response, remission, and predictors of remission in rheumatoid arthritis patients treated with tumor necrosis factor-alpha blockers: the GISEA studyLuana Mancarella
Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy
J Rheumatol 34:1670-3. 2007..To assess the prevalence of good clinical response and remission in rheumatoid arthritis (RA) patients with longstanding disease treated with anti-tumor necrosis factor-alpha (TNF-alpha) drugs at outpatient clinics... - Cytomegalovirus-associated cutaneous vasculopathy and scleroderma sans inclusion body changeCynthia M Magro
Department of Pathology, Weill College of Medicine, Cornell University, New York, NY 10021, USA
Hum Pathol 38:42-9. 2007..The role of tumor necrosis factor alpha blockers in scleroderma cases temporally associated with CMV infection requires further evaluation... - Autoimmune-like pulmonary disease in association with parvovirus B19: a clinical, morphologic, and molecular study of 12 casesCynthia M Magro
Department of Pathology, Ohio State University, Columbus, Ohio, USA
Appl Immunohistochem Mol Morphol 14:208-16. 2006..The antiphospholipid profile revealed antiphospholipids in 7 of the 11 patients tested. This report highlights a possible causal role for parvovirus B19 in the pathogenesis of select pulmonary disorders... - Parvovirus B19 infection of cultured skin fibroblasts from systemic sclerosis patients: comment on the article by Ray et alClodoveo Ferri
Arthritis Rheum 46:2262-3; author reply 2263-4. 2002 - [The treatment of skin ulcers in systemic sclerosis: use of granulocyte-colony stimulating factor (G-CSF) in 26 patients]Dilia Giuggioli
Cattedra e UO di Reumatologia, Universita di Modena e Reggio Emilia, Italia
Reumatismo 58:26-30. 2006..To verify the effectiveness of G-CSF in the treatment of non-healing skin lesions in SSc patients... - Spontaneous chromosome damage (micronuclei) in systemic sclerosis and Raynaud's phenomenonGiovanni Porciello
Istituto di Reumatologia, University of Siena, Italy
J Rheumatol 30:1244-7. 2003.... - The dermatopathologic manifestations of hepatitis C infection: a clinical, histological, and molecular assessment of 35 casesA Neil Crowson
Centeral Medical Laboratories, Winnipeg, Manitoba, Canada
Hum Pathol 34:573-9. 2003..Tropism of the virus to B lymphocytes provides a mechanism for the development of low-grade clonal B cell lymphoproliferative disease in this setting... - The assessment of anti-endothelial cell antibodies in scleroderma-associated pulmonary fibrosis. A study of indirect immunofluorescent and western blot analysis in 49 patients with sclerodermaRaghav Wusirika
College of Medicine and Public Health, Ohio State University, 410 W 10th Ave, Columbus, OH 43210, USA
Am J Clin Pathol 120:596-606. 2003..The indirect immunofluorescent rodent lung assay and Western blot data support a potential role of anti-endothelial cell antibodies in the propagation of scleroderma-associated pulmonary disease... - Chromosome aberrations in Raynaud's phenomenonGiovanni Porciello
Servizio di Reumatologia Ospedale Misericordia e Dolce di Prato, Italy
Eur J Dermatol 14:327-31. 2004..No prevalence of aneuploidogenic or clastogenic events in micronucleus formation is revealed by fluorescence in situ hybridisation analysis...