Francesco Feo

Summary

Affiliation: University of Sassari
Country: Italy

Publications

  1. ncbi request reprint Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition
    F Feo
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, via P Manzella 4, 07100 Sasssari, Italy
    Biochim Biophys Acta 1765:126-47. 2006
  2. doi request reprint Genetic and epigenetic control of molecular alterations in hepatocellular carcinoma
    Francesco Feo
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, 07100 Sassari, Italy
    Exp Biol Med (Maywood) 234:726-36. 2009
  3. doi request reprint Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype
    Maddalena Frau
    Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
    J Hepatol 55:111-9. 2011
  4. doi request reprint SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis
    Diego F Calvisi
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy
    Gastroenterology 137:1816-26.e1-10. 2009
  5. ncbi request reprint Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats
    Maria R De Miglio
    Division of Experimental Pathology and Oncology, Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    Int J Cancer 111:9-16. 2004
  6. doi request reprint Aberrant iNOS signaling is under genetic control in rodent liver cancer and potentially prognostic for the human disease
    Diego F Calvisi
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, 07100 Sassari, Italy
    Carcinogenesis 29:1639-47. 2008
  7. doi request reprint Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control
    Diego F Calvisi
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy
    Int J Cancer 123:2057-64. 2008
  8. doi request reprint An expression signature of phenotypic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis
    Maddalena Frau
    Department of Clinical and Experimental Medicine, Division of Experimental Pathology and Oncology, University of Sassari, 07100, Sassari, Italy
    Cell Oncol (Dordr) 35:163-73. 2012
  9. doi request reprint The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease
    Diego F Calvisi
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy
    Int J Cancer 126:1275-81. 2010
  10. ncbi request reprint Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis
    Maria M Simile
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Italy
    Carcinogenesis 26:417-27. 2005

Collaborators

  • Diego F Calvisi
  • Claudio F Feo
  • Toshikazu Ushijima
  • Matthias Evert
  • Snorri S Thorgeirsson
  • Geoffrey A Wood
  • Chiara Brignole
  • Maddalena Frau
  • Rosa M Pascale
  • Maria M Simile
  • Maria R De Miglio
  • Maria A Seddaiu
  • Maria R Muroni
  • Lucia Daino
  • Maria L Tomasi
  • Patrizia Virdis
  • Giuseppina Asara
  • Giuliana Solinas
  • Maria I Demartis
  • Stefania Brozzetti
  • Giovanni M Bosinco
  • Sara Ladu
  • Maria D Muntoni
  • Fabiana Salis
  • Giovanni Massarelli
  • Gavinella Latte
  • M R De Miglio
  • Satoshi Yamashita
  • Ju Seog Lee
  • Piero Bonelli
  • Fiorella Biasi
  • Federico Pinna
  • Daniela Mele
  • Giovanni M Careddu
  • Eraldo Sanna-Passino
  • Gabriella Pagnan
  • Fabio Pastorino
  • Mirco Ponzoni
  • Leslie K L Wong
  • Silvia Serra
  • Michael C Archer
  • Kelvin M T Kwong
  • Franca R Pulina
  • Daniela Casabona
  • M Frau
  • M R Muroni
  • M M Simile
  • G Asara
  • R M Pascale
  • P Virdis
  • M A Seddaiu

Detail Information

Publications26

  1. ncbi request reprint Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition
    F Feo
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, via P Manzella 4, 07100 Sasssari, Italy
    Biochim Biophys Acta 1765:126-47. 2006
    ..Thus, protective mechanisms seem to be modulated by HCC modifiers, and differences in their efficiency influence the susceptibility to hepatocarcinogenesis and probably the prognosis of human HCC...
  2. doi request reprint Genetic and epigenetic control of molecular alterations in hepatocellular carcinoma
    Francesco Feo
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, 07100 Sassari, Italy
    Exp Biol Med (Maywood) 234:726-36. 2009
    ....
  3. doi request reprint Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype
    Maddalena Frau
    Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
    J Hepatol 55:111-9. 2011
    ..MYBL2 is implicated in human malignancies and over expressed in hepatocellular carcinoma (HCC). We investigated Mybl2 role in the acquisition of susceptibility to HCC and tumor progression...
  4. doi request reprint SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis
    Diego F Calvisi
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy
    Gastroenterology 137:1816-26.e1-10. 2009
    ..We investigated the role of the ubiquitin ligase subunits CKS1 and SKP2, which regulate proteasome degradation of cell cycle regulators, in HCC progression...
  5. ncbi request reprint Polygenic control of hepatocarcinogenesis in Copenhagen x F344 rats
    Maria R De Miglio
    Division of Experimental Pathology and Oncology, Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    Int J Cancer 111:9-16. 2004
    ....
  6. doi request reprint Aberrant iNOS signaling is under genetic control in rodent liver cancer and potentially prognostic for the human disease
    Diego F Calvisi
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, 07100 Sassari, Italy
    Carcinogenesis 29:1639-47. 2008
    ..These findings indicate that iNOS cross talk with NF-kB and Ha-RAS/ERK cascades influences HCC growth and prognosis, suggesting that key component of iNOS signaling could represent important therapeutic targets for human HCC...
  7. doi request reprint Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control
    Diego F Calvisi
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy
    Int J Cancer 123:2057-64. 2008
    ..Dusp1 possesses a prominent role in the acquisition of the phenotype resistant to HCC by BN rats, whereas late activation of RassF1A/Nore1A and Dab2IP/Ask1 axes is implicated in the highest apoptosis characteristic of BN HCC...
  8. doi request reprint An expression signature of phenotypic resistance to hepatocellular carcinoma identified by cross-species gene expression analysis
    Maddalena Frau
    Department of Clinical and Experimental Medicine, Division of Experimental Pathology and Oncology, University of Sassari, 07100, Sassari, Italy
    Cell Oncol (Dordr) 35:163-73. 2012
    ..We analyzed gene expression patterns of dysplastic liver nodules (DNs) and hepatocellular carcinomas (HCCs) chemically-induced in F344 and BN rats, respectively susceptible and resistant to hepatocarcinogenesis...
  9. doi request reprint The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease
    Diego F Calvisi
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy
    Int J Cancer 126:1275-81. 2010
    ....
  10. ncbi request reprint Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis
    Maria M Simile
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Italy
    Carcinogenesis 26:417-27. 2005
    ..Moreover, they demonstrate a partially new mechanism of HPR chemopreventive effect and indicate the potential clinical relevance of this compound for prevention of hepatocellular carcinoma...
  11. ncbi request reprint Altered methionine metabolism and global DNA methylation in liver cancer: relationship with genomic instability and prognosis
    Diego F Calvisi
    Division of Experimental Pathology and Oncology, Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    Int J Cancer 121:2410-20. 2007
    ..However, a small human HCC subgroup, as c-Myc/Tgf-alpha tumors, may develop in the absence of alterations in DNA methylation...
  12. ncbi request reprint Mapping a sex hormone-sensitive gene determining female resistance to liver carcinogenesis in a congenic F344.BN-Hcs4 rat
    Maria R De Miglio
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy
    Cancer Res 66:10384-90. 2006
    ....
  13. ncbi request reprint Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer
    Rosa M Pascale
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Italy
    Hepatology 42:1310-9. 2005
    ..The results also suggest that protection by CDC37 and CRM1 against growth restraint by P16(INK4A) influences the prognosis of human hepatocellular carcinoma...
  14. ncbi request reprint Down-regulation of c-myc and Cyclin D1 genes by antisense oligodeoxy nucleotides inhibits the expression of E2F1 and in vitro growth of HepG2 and Morris 5123 liver cancer cells
    Maria M Simile
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, I 07100 Sassari, Italy
    Carcinogenesis 25:333-41. 2004
    ..Thus, interactions of c-MYC and CYCLIN D1 with E2F1 gene are essential for cell cycle activity in hepatoma cells, and their inhibition may have a therapeutic effect...
  15. doi request reprint Activation of v-Myb avian myeloblastosis viral oncogene homolog-like2 (MYBL2)-LIN9 complex contributes to human hepatocarcinogenesis and identifies a subset of hepatocellular carcinoma with mutant p53
    Diego F Calvisi
    Department of Clinical and Experimental Medicine and Oncology, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy
    Hepatology 53:1226-36. 2011
    ..In particular, our data indicate that MYBL2-LIN9 complex integrity contributes to survival of DNA damaged p53(-/-) cells. Thus, MYBL2 inhibition could represent a valuable adjuvant for treatments against human HCC with mutated p53...
  16. doi request reprint Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression
    Maddalena Frau
    Department of Clinical and Experimental Medicine, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy
    Hepatology 56:165-75. 2012
    ..Low MATI/III:MATII ratio is a prognostic marker that contributes to determine a phenotype susceptible to HCC and patients' survival...
  17. ncbi request reprint Phenotypic reversion of rat neoplastic liver nodules is under genetic control
    Maria R De Miglio
    Department of Biomedical Sciences, University of Sassari, Sassari, Italy
    Int J Cancer 105:70-5. 2003
    ..Loci affecting remodeling map to chromosomal regions syntenic to chromosomal segments of human HCC showing structural abnormalities...
  18. doi request reprint Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma
    Diego F Calvisi
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, 07100 Sassari, Italy
    Cancer Res 68:4192-200. 2008
    ..Thus, DUSP1 may represent a valuable prognostic marker and ERK, CKS1, or SKP2 potential therapeutic targets for human HCC...
  19. ncbi request reprint Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/beta-catenin pathway and progression of early lesions in the rat
    Maria R De Miglio
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, 07100 Sassari, Italy
    Carcinogenesis 28:2367-74. 2007
    ..These data indicate that inheritance of predisposition to CRC depends on interplays of several genetic factors, and suggest a possible mechanism of polygenic control of CRC progression...
  20. ncbi request reprint Chromosome mapping of multiple loci affecting the genetic predisposition to rat liver carcinogenesis
    Maria R De Miglio
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, 07100 Sassari, Italy
    Cancer Res 62:4459-63. 2002
    ..These data indicate that inheritance of predisposition to rat liver tumor is characterized by the interplay of several genetic factors and suggest some possible mechanisms of polygenic control of human liver cancer...
  21. doi request reprint Prognostic markers and putative therapeutic targets for hepatocellular carcinoma
    Maddalena Frau
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, 07100 Sassari, Italy
    Mol Aspects Med 31:179-93. 2010
    ..They may take advantage from the comparative analysis of signal transduction in HCCs differently prone to progress, in rats and humans...
  22. ncbi request reprint Dissection of signal transduction pathways as a tool for the development of targeted therapies of hepatocellular carcinoma
    Diego F Calvisi
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy
    Rev Recent Clin Trials 2:217-36. 2007
    ..Attempts to overcome this difficulty include discovery of new therapeutic targets, gene therapy directed to different molecular targets essential for tumor cell survival and specifically directed to HCC subtypes...
  23. ncbi request reprint Cell cycle deregulation in liver lesions of rats with and without genetic predisposition to hepatocarcinogenesis
    Rosa M Pascale
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy
    Hepatology 35:1341-50. 2002
    ..In conclusion, these results suggest deregulation of G1 and S phases in liver lesions of susceptible rats and block of G1-S transition in lesions of resistant strains, which explains their low progression capacity...
  24. ncbi request reprint Deregulation of signalling pathways in prognostic subtypes of hepatocellular carcinoma: novel insights from interspecies comparison
    Diego F Calvisi
    Department of Clinical and Experimental Medicine, Division of Experimental Pathology and Oncology, University of Sassari, Sassari, Italy
    Biochim Biophys Acta 1826:215-37. 2012
    ..This is of prime importance for the selection of patient subgroups that are most likely to obtain clinical benefit and, hence, for successful development of targeted therapies for liver cancer...
  25. ncbi request reprint Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine
    Rosa M Pascale
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Italy
    Alcohol 27:193-8. 2002
    ..Other possible mechanisms of SAM treatment include inhibition of polyamine synthesis, linked to partial transformation of SAM into 5'-methylthioadenosine (MTA), and antioxidant and antifibrogenic activities of both SAM and MTA...
  26. ncbi request reprint Frequent loss of heterozygosity at the Hcr1 (hepatocarcinogenesis resistance) locus on chromosome 10 in primary hepatocellular carcinomas from LFF1 rat strain
    M R De Miglio
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari. Italy
    Hepatology 33:1110-7. 2001
    ..Our map provides information toward cloning putative oncosuppressor genes associated with this carcinoma...