Chiara Fenoglio

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. pmc An emerging role for long non-coding RNA dysregulation in neurological disorders
    Chiara Fenoglio
    Department of Pathophysiology and Transplantation, University of Milan, Dino Ferrari Center, IRCCS Ca Granda Foundation Ospedale Maggiore Policlinico, Via F Sforza 35, Milan 20122, Italy
    Int J Mol Sci 14:20427-42. 2013
  2. pmc Expression and Genetic Analysis of MicroRNAs Involved in Multiple Sclerosis
    Elisa Ridolfi
    Department of Pathophysiology and Transplantation, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Int J Mol Sci 14:4375-84. 2013
  3. pmc Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 18:603-12. 2009
  4. doi request reprint Expression and genetic analysis of miRNAs involved in CD4+ cell activation in patients with multiple sclerosis
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurosci Lett 504:9-12. 2011
  5. ncbi request reprint Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males
    C Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Genes Immun 11:497-503. 2010
  6. pmc MicroRNAs as Active Players in the Pathogenesis of Multiple Sclerosis
    Chiara Fenoglio
    Department of Pathophysiology and Transplantation, Dino Ferrari Center, University of Milan, IRCCS Foundation Cà Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy
    Int J Mol Sci 13:13227-39. 2012
  7. ncbi request reprint Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122, Milan, Italy
    J Neurol Sci 267:86-90. 2008
  8. doi request reprint Role of OLR1 and its regulating hsa-miR369-3p in Alzheimer's disease: genetics and expression analysis
    Maria Serpente
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 26:787-93. 2011
  9. doi request reprint MCP-1 A-2518G polymorphism: effect on susceptibility for frontotemporal lobar degeneration and on cerebrospinal fluid MCP-1 levels
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 17:125-33. 2009
  10. ncbi request reprint P-selectin glycoprotein ligand-1 variable number of tandem repeats (VNTR) polymorphism in patients with multiple sclerosis
    Diego Scalabrini
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122 Milan, Italy
    Neurosci Lett 388:149-52. 2005

Detail Information

Publications56

  1. pmc An emerging role for long non-coding RNA dysregulation in neurological disorders
    Chiara Fenoglio
    Department of Pathophysiology and Transplantation, University of Milan, Dino Ferrari Center, IRCCS Ca Granda Foundation Ospedale Maggiore Policlinico, Via F Sforza 35, Milan 20122, Italy
    Int J Mol Sci 14:20427-42. 2013
    ..In this review, the current state of knowledge linking lncRNAs to different neurological disorders is discussed and potential future directions are considered. ..
  2. pmc Expression and Genetic Analysis of MicroRNAs Involved in Multiple Sclerosis
    Elisa Ridolfi
    Department of Pathophysiology and Transplantation, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Int J Mol Sci 14:4375-84. 2013
    ..Moreover, miR-223 rs1044165 polymorphism likely acts as a protective factor, while miR-23a rs3745453 variant seems to act as a risk factor for MS...
  3. pmc Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 18:603-12. 2009
    ..14, CC = 1.22 +/- 0.23; P = 0.013). These data argue against a direct role of GRN as a susceptibility factor for sporadic AD but support a role of GRN as a disease-modifying gene, possibly contributing to the failure of neuronal survival...
  4. doi request reprint Expression and genetic analysis of miRNAs involved in CD4+ cell activation in patients with multiple sclerosis
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurosci Lett 504:9-12. 2011
    ..miRNA dysregulation may contribute to the pathogenesis of MS and highlights the possibility to define different disease entities with specific miRNAs profile...
  5. ncbi request reprint Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males
    C Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Genes Immun 11:497-503. 2010
    ..8% vs 70.9%; P=0.001, OR 0.52, 95% CI 0.4-0.8). Therefore, GRN haplotypes likely influence the risk of developing PPMS in males...
  6. pmc MicroRNAs as Active Players in the Pathogenesis of Multiple Sclerosis
    Chiara Fenoglio
    Department of Pathophysiology and Transplantation, Dino Ferrari Center, University of Milan, IRCCS Foundation Cà Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy
    Int J Mol Sci 13:13227-39. 2012
    ....
  7. ncbi request reprint Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122, Milan, Italy
    J Neurol Sci 267:86-90. 2008
    ..06-0.50), whereas no significant differences were observed in females. Therefore, the presence of the AT haplotype in chromosome 16 chemokine cluster is likely to confer a decreased risk of developing MS, particularly in males...
  8. doi request reprint Role of OLR1 and its regulating hsa-miR369-3p in Alzheimer's disease: genetics and expression analysis
    Maria Serpente
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 26:787-93. 2011
    ..Nevertheless, the limited power of the study requires further investigations with a larger sample size...
  9. doi request reprint MCP-1 A-2518G polymorphism: effect on susceptibility for frontotemporal lobar degeneration and on cerebrospinal fluid MCP-1 levels
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 17:125-33. 2009
    ..21 +/- 44.57 versus 395.87 +/- 21.92 pg/ml, P = 0.045). The MCP-1 A-2518G SNP acts as protective factor for sporadic FTLD, possibly by influencing MCP-1 production...
  10. ncbi request reprint P-selectin glycoprotein ligand-1 variable number of tandem repeats (VNTR) polymorphism in patients with multiple sclerosis
    Diego Scalabrini
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122 Milan, Italy
    Neurosci Lett 388:149-52. 2005
    ..As this allele has been demonstrated to have a very low efficiency in mediating lymphocyte binding to brain endothelium during attacks, its high frequency in PP-MS could be related to the absence of exacerbations in such patients...
  11. doi request reprint Candidate gene analysis of semaphorins in patients with Alzheimer's disease
    Chiara Villa
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    Neurol Sci 31:169-73. 2010
    ..This high degree of conservation of Sema3A suggests a very important role for this protein. However, neither Sema3A nor Sema4D likely influence the susceptibility to AD...
  12. ncbi request reprint Candidate gene analysis of SPARCL1 gene in patients with multiple sclerosis
    Diego Scalabrini
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurosci Lett 425:173-6. 2007
    ..However, the frequency of the C/C genotype of rs1049544 was decreased in male patients, possibly conferring a lower risk of developing MS in male population. Further studies are needed to clarify this issue...
  13. ncbi request reprint Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with Alzheimer's disease
    Chiara Villa
    Neurology Unit, Department of Pathophysiology and Transplantation Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 35:487-94. 2013
    ..Moreover, Sp1 rs176951056 T allele is likely a protective factor in the male population...
  14. doi request reprint Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic Mild Cognitive Impairment converted to Alzheimer's disease
    Miryam Carecchio
    Department of Neurological Sciences, Dino Ferrari Centre, IRCCS Fondazione Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
    J Neurol Sci 287:291-3. 2009
    ..We thus encourage the inclusion of this non-invasive and easy test in clinical practice...
  15. doi request reprint A novel MAPT mutation associated with the clinical phenotype of progressive nonfluent aphasia
    Chiara Villa
    Department of Neurological Sciences, University of Milan, IRCCS Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 26:19-26. 2011
    ..The amino acid change likely compromises the ability of tau to properly regulate the dynamic behavior of microtubules...
  16. ncbi request reprint Is M129V of PRNP gene associated with Alzheimer's disease? A case-control study and a meta-analysis
    Roberto Del Bo
    Dino Ferrari Centre, Department of Neurological Sciences, University of Milan and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Padiglione Ponti, Milano, Italy
    Neurobiol Aging 27:770.e1-770.e5. 2006
    ..We also observed that MM genotype and M allele represent a risk factor for AD, independently from the ethnic background, providing a significant but modest association between this polymorphism and AD...
  17. doi request reprint Role of hnRNP-A1 and miR-590-3p in neuronal death: genetics and expression analysis in patients with Alzheimer disease and frontotemporal lobar degeneration
    Chiara Villa
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Rejuvenation Res 14:275-81. 2011
    ..0237). According to these findings, hnRNP-A1 and its transcription regulatory factor miR-590-3p are disregulated in patients with AD, and the hnRNP-A1 rs7967622 C/C genotype is likely a risk factor for FTLD in male populations...
  18. ncbi request reprint GRN variability contributes to sporadic frontotemporal lobar degeneration
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 19:171-7. 2010
    ..This SNP is likely located in a regulatory region, thus an effect on GRN mRNA levels may be of mechanistic importance...
  19. doi request reprint BAG1 is a protective factor for sporadic frontotemporal lobar degeneration but not for Alzheimer's disease
    Eliana Venturelli
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 23:701-7. 2011
    ..BAG-1 rs706118 SNP likely acts as protective factor for sporadic FTLD, but not for AD, suggesting its specific role in a pathogenic event in FTLD. Nevertheless, a replication study would be needed to confirm these preliminary results...
  20. doi request reprint Is KIF24 a genetic risk factor for Frontotemporal Lobar Degeneration?
    Eliana Venturelli
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurosci Lett 482:240-4. 2010
    ..05). The KIF24 rs17350674 polymorphism likely acts as a risk factor for sporadic FTLD, but a replication study would be needed to confirm these preliminary findings...
  21. ncbi request reprint The T-786C NOS3 polymorphism in Alzheimer's disease: association and influence on gene expression
    Eliana Venturelli
    Department of Neurological Sciences, Dino Ferrari Center and CEND, University of Milan, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurosci Lett 382:300-3. 2005
    ....
  22. ncbi request reprint CCR2-64I polymorphism and CCR5Delta32 deletion in patients with Alzheimer's disease
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    J Neurol Sci 225:79-83. 2004
    ..Stratifying by the presence of ApoE varepsilon4 allele, gender or age at onset, no differences in either allele frequencies were observed...
  23. ncbi request reprint Candidate gene analysis of IP-10 gene in patients with Alzheimer's disease
    Eliana Venturelli
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Italy
    Neurosci Lett 404:217-21. 2006
    ..However, a novel rare polymorphism has been identified, which could exert a role in AD susceptibility. Thus, further studies on larger populations are needed before confidently excluding IP-10 as a susceptibility gene for AD...
  24. ncbi request reprint Association of a NOS1 promoter repeat with Alzheimer's disease
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Ospedale Maggiore Policlinico IRCCS, Milan, Italy
    Neurobiol Aging 29:1359-65. 2008
    ..83). Therefore, short alleles of the NOS1 exon 1f-VNTR are likely to be susceptibility factors for AD, and interact with the epsilon 4 allele to markedly increase the AD risk...
  25. ncbi request reprint Novel evidence of phenotypical variability in the hexanucleotide repeat expansion in chromosome 9
    Chiara Cerami
    Neurorehabilitation Unit, Department of Clinical Neurosciences, San Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy
    J Alzheimers Dis 35:455-62. 2013
    ..The present findings confirm the importance of screening for the hexanucleotide repeat expansion in chromosome 9 in the case not only of familial, but also of sporadic FTD, and in the presence of atypical cognitive disorders...
  26. ncbi request reprint Oxidative imbalance in patients with mild cognitive impairment and Alzheimer's disease
    Ilaria Guidi
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Neurobiol Aging 27:262-9. 2006
    ..ROS levels appear to be correlated with age rather than with a specific dementing disorder, thus leading to the hypothesis that oxidative imbalance observed in AD could be due to a decreased TAC...
  27. ncbi request reprint SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Italy
    Neurosci Lett 394:92-6. 2006
    ..Therefore, none of the SNPs investigated is associated with MS, although this analysis does not conclusively exclude SELPLG and SELP as genetic risk factors for MS as much variation remains untested...
  28. ncbi request reprint Intrathecal levels of IL-6, IL-11 and LIF in Alzheimer's disease and frontotemporal lobar degeneration
    Daniela Galimberti
    Dept of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    J Neurol 255:539-44. 2008
    ....
  29. ncbi request reprint Intrathecal chemokine synthesis in mild cognitive impairment and Alzheimer disease
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Arch Neurol 63:538-43. 2006
    ....
  30. ncbi request reprint Decreased circulating miRNA levels in patients with primary progressive multiple sclerosis
    Chiara Fenoglio
    Department of Pathophysiology and Transplantation Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Italy
    Mult Scler 19:1938-42. 2013
    ..Circulating miRNA profiling could thus represent a new avenue to identify easily detectable disease biomarkers. ..
  31. ncbi request reprint Genetics and expression analysis of the specificity protein 4 gene (SP4) in patients with Alzheimer's disease and frontotemporal lobar degeneration
    Chiara Villa
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy
    J Alzheimers Dis 31:537-42. 2012
    ..However, Sp4 mRNA levels are upregulated in patients, possibly resulting in an aberrant expression of downstream target genes involved in the pathogenesis of both diseases...
  32. ncbi request reprint Influence of the Glu298Asp polymorphism of NOS3 on age at onset and homocysteine levels in AD patients
    Ilaria Guidi
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Neurobiol Aging 26:789-94. 2005
    ..Besides, a contribution of the Glu/Glu genotype in increasing tHcy levels has been observed...
  33. ncbi request reprint Absence of TREM2 polymorphisms in patients with Alzheimer's disease and Frontotemporal Lobar Degeneration
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    Neurosci Lett 411:133-7. 2007
    ..Further studies, including a functional analysis, are certainly required to clarify the role of TREM2 in neurodegenerative processes...
  34. doi request reprint Autosomal dominant frontotemporal lobar degeneration due to the C9ORF72 hexanucleotide repeat expansion: late-onset psychotic clinical presentation
    Daniela Galimberti
    Neurology Unit, Department of Phatophysiology and Transplantation, University of Milan, Fondazione Cà Granda, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Policlinico, Italy
    Biol Psychiatry 74:384-91. 2013
    ..Atypical presentations have been described, particularly psychosis...
  35. ncbi request reprint Novel missense progranulin gene mutation associated with the semantic variant of primary progressive aphasia
    Chiara Cerami
    Neurorehabilitation Unit, Department of Clinical Neurosciences, San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Via Olgettina 60, Milan, Italy
    J Alzheimers Dis 36:415-20. 2013
    ..This case confirms that GRN represents one of the most frequent FTLD genetic causes, suggesting that a screening is indicated in the case of svPPA presentation. ..
  36. pmc Progranulin gene variability and plasma levels in bipolar disorder and schizophrenia
    Daniela Galimberti
    Department of Neurological Sciences, University of Milan, IRCCS Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    PLoS ONE 7:e32164. 2012
    ..Nevertheless, a larger replication analysis would be needed to confirm these preliminary results...
  37. doi request reprint GSK3β genetic variability in patients with Multiple Sclerosis
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurosci Lett 497:46-8. 2011
    ..7%, P=0.01; OR: 1.72, 95%CI: 1.13-2.61). GSK3β rs334558 is a susceptibility factor for MS. As it is located in the promoter region, a possible explanatory mechanism could be an influence of the variant on the gene transcription rate...
  38. doi request reprint Phenotypic heterogeneity of the GRN Asp22fs mutation in a large Italian kindred
    Anna M Pietroboni
    Department of Neurological Sciences, University of Milan, IRCCS Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 24:253-9. 2011
    ....
  39. pmc No major progranulin genetic variability contribution to disease etiopathogenesis in an ALS Italian cohort
    Roberto Del Bo
    Dino Ferrari Centre, Department of Neurological Sciences, University of Milan, IRCCS Foundation Ospedale Maggiore Policlinico Mangiagalli and Regina Elena, Milan, Italy
    Neurobiol Aging 32:1157-8. 2011
    ..The p.S120Y variant may characterize rare patients with SALS, although its pathogenetic mechanism remains to be elucidated...
  40. ncbi request reprint Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer's disease
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Neurobiol Aging 27:1763-8. 2006
    ..Nevertheless, as MCP-1 is likely to play a role in several pathologies with an inflammatory component, a possible usefulness as an early AD biomarker would be possible only in combination with other molecules...
  41. doi request reprint Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration
    Daniela Galimberti
    Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Neurol Sci 34:899-903. 2013
    ..05). GRN promoter methylation was not correlated with age. In conclusion, the degree of methylation of the GRN promoter is increased in patients with FTLD as compared with controls, likely leading to a decreased expression of GRN...
  42. pmc Cerebrospinal fluid progranulin levels in patients with different multiple sclerosis subtypes
    Milena De Riz
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122 Milan, Italy
    Neurosci Lett 469:234-6. 2010
    ..A positive correlation between progranulin CSF levels and age was observed in patients (rho=0.29, P=0.03). According to these data, progranulin does not likely play a major role in the pathogenesis of MS...
  43. ncbi request reprint Vascular endothelial growth factor gene variability is associated with increased risk for AD
    Roberto Del Bo
    Department of Neurological Sciences, Dino Ferrari Centre and Centre of Excellence on Neurodegenerative Diseases, University of Milan, I R C C S Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Ann Neurol 57:373-80. 2005
    ..These findings suggest that polymorphisms within the promoter region of the VEGF gene confer greater risk for AD, probably by reducing its neuroprotective effect, and confirm the biological role of VEGF in neurodegenerative processes...
  44. ncbi request reprint Candidate gene analysis of selectin cluster in patients with multiple sclerosis
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Neurol 256:832-3. 2009
    ....
  45. ncbi request reprint C9ORF72 repeat expansion not detected in patients with multiple sclerosis
    Chiara Fenoglio
    Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Dino Ferrari Center, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Neurobiol Aging 35:1213.e1-2. 2014
    ..No pathogenic expansion was found in MS and control populations, suggesting that C9ORF72 does not play a major role in MS pathogenesis. ..
  46. doi request reprint GRN Thr272fs clinical heterogeneity: a case with atypical late onset presenting with a dementia with Lewy bodies phenotype
    Beatrice Arosio
    Geriatric Unit, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 35:669-74. 2013
    ..A major contributing factor to the diagnosis was the testing of plasmatic progranulin levels (extremely low), which prompted us to sequence GRN...
  47. doi request reprint Early onset behavioral variant frontotemporal dementia due to the C9ORF72 hexanucleotide repeat expansion: psychiatric clinical presentations
    Andrea Arighi
    Department of Neurological Sciences, University of Milan, Dino Ferrari Center, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy
    J Alzheimers Dis 31:447-52. 2012
    ..The description of these cases underlines that the hexanucleotide repeat expansion in chromosome 9 could be associated with early onset psychiatric presentations...
  48. ncbi request reprint E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122, Milan, Italy
    J Neuroimmunol 165:201-5. 2005
    ..The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS...
  49. ncbi request reprint Incomplete penetrance of the C9ORF72 hexanucleotide repeat expansions: frequency in a cohort of geriatric non-demented subjects
    Daniela Galimberti
    Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy
    J Alzheimers Dis 39:19-22. 2014
    ..We have not had information on her condition since that time. These results suggest that the penetrance of the mutation is definitely incomplete. ..
  50. ncbi request reprint Inflammation in neurodegenerative disorders: friend or foe?
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Ospedale Maggiore Policlinico IRCCS, Via F Sforza 35, 20122, Milan, Italy
    Curr Aging Sci 1:30-41. 2008
    ..With these premises, genetic studies recently carried out will be described and discussed in detail...
  51. doi request reprint FUS/TLS genetic variability in sporadic frontotemporal lobar degeneration
    Claudia Cantoni
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 19:1317-22. 2010
    ..Haplotype analysis failed to detect haplotypes associated with FTLD. According to these results, FUS/TLS is not a susceptibility factor for the development of sporadic FTLD...
  52. ncbi request reprint Phenotypic variability associated with the C9ORF72 hexanucleotide repeat expansion: a sporadic case of frontotemporal lobar degeneration with prodromal hyposmia and predominant semantic deficits
    Carlo Abbate
    Geriatric Unit, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 40:849-55. 2014
    ..Levels of cerebrospinal fluid biomarkers (amyloid-β, tau and p-tau) were normal. This description further confirms the heterogeneous presentation of the C9ORF72 mutation. ..
  53. ncbi request reprint The C9ORF72 hexanucleotide repeat expansion is a rare cause of schizophrenia
    Daniela Galimberti
    Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy Electronic address
    Neurobiol Aging 35:1214.e7-1214.e10. 2014
    ..The repeat expansion in the C9ORF72 gene is a rare, but possible, cause of schizophrenic spectrum disorders. We cannot rule out however whether the number of repeats influence the phenotype. ..
  54. doi request reprint The progranulin (GRN) Cys157LysfsX97 mutation is associated with nonfluent variant of primary progressive aphasia clinical phenotype
    Francesca Caso
    Department of Neurology, Scientific Institute and University Vita Salute San Raffaele, Milan, Italy
    J Alzheimers Dis 28:759-63. 2012
    ..This patient's description expands the spectrum of clinical presentations of frontotemporal lobar degeneration caused by the GRN Cys157LysfsX97 mutation...
  55. pmc Screening of the PFN1 gene in sporadic amyotrophic lateral sclerosis and in frontotemporal dementia
    Cinzia Tiloca
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Neurobiol Aging 34:1517.e9-10. 2013
    ..G15G in another patient, but none in a panel of 1512 control subjects. Our results suggest that PFN1 mutations in sporadic ALS and in FTD are rare, at least in the Italian population...
  56. ncbi request reprint MCP-1 in Alzheimer's disease patients: A-2518G polymorphism and serum levels
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F Sforza 35, 20122 Milan, Italy
    Neurobiol Aging 25:1169-73. 2004
    ..The A-2518G polymorphism in MCP-1 gene does not seem to be a risk factor for the development of AD, but its presence correlates with higher levels of serum MCP-1, which can contribute to increase the inflammatory process occurring in AD...