M Federici

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program
    M Federici
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    Diabetes 50:1290-301. 2001
  2. ncbi Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells
    Massimo Federici
    Department of Internal Medicine, University of Tor Vergata, Rome, Italy
    Circulation 106:466-72. 2002
  3. ncbi Vascular, metabolic, and inflammatory abnormalities in normoglycemic offspring of patients with type 2 diabetes mellitus
    Manfredi Tesauro
    Dipartimento di Medicina Interna, Universita di Tor Vergata, Rome, Italy
    Metabolism 56:413-9. 2007
  4. pmc Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha
    Massimo Federici
    Center for Atherosclerosis, Policlinico Tor Vergata University Hospital, Rome, Italy
    J Clin Invest 115:3494-505. 2005
  5. ncbi The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy
    Massimo Federici
    Department of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 56100 Rome, Italy
    Diabetes 52:887-90. 2003
  6. ncbi The strange case of G972R IRS-1 variant and diabetes. Do type 1 and type 2 diabetes share common genes?
    Massimo Federici
    Department of Internal Medicine, Center for Atherosclerosis and Laboratory of Molecular Medicine, University of Rome Tor Vergata, Rome, Italy
    Mol Genet Metab 81:261-2. 2004
  7. pmc TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice
    Rossella Menghini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Diabetes 61:454-62. 2012
  8. pmc Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness
    Marina Cardellini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Diabetes 60:3265-70. 2011
  9. doi Overexpression of tissue inhibitor of metalloproteinase 3 in macrophages reduces atherosclerosis in low-density lipoprotein receptor knockout mice
    Viviana Casagrande
    Department of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Arterioscler Thromb Vasc Biol 32:74-81. 2012
  10. ncbi The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets
    M Federici
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome-'Tor Vergata, 00133 Rome, Italy
    FASEB J 15:22-24. 2001

Detail Information

Publications61

  1. ncbi High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program
    M Federici
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    Diabetes 50:1290-301. 2001
    ..These data suggest that in human islets, high glucose may modulate the balance of proapoptotic and antiapoptotic Bcl proteins toward apoptosis, thus favoring beta-cell death...
  2. ncbi Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells
    Massimo Federici
    Department of Internal Medicine, University of Tor Vergata, Rome, Italy
    Circulation 106:466-72. 2002
    ..We studied the effects of O-GlcNAcylation on insulin signaling in human coronary artery endothelial cells...
  3. ncbi Vascular, metabolic, and inflammatory abnormalities in normoglycemic offspring of patients with type 2 diabetes mellitus
    Manfredi Tesauro
    Dipartimento di Medicina Interna, Universita di Tor Vergata, Rome, Italy
    Metabolism 56:413-9. 2007
    ....
  4. pmc Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha
    Massimo Federici
    Center for Atherosclerosis, Policlinico Tor Vergata University Hospital, Rome, Italy
    J Clin Invest 115:3494-505. 2005
    ..Our results suggest that an interplay between reduced insulin action and unchecked TACE activity promotes diabetes and vascular inflammation...
  5. ncbi The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy
    Massimo Federici
    Department of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 56100 Rome, Italy
    Diabetes 52:887-90. 2003
    ..49 +/- 0.058, n = 34, and 0.76 +/- 0.066, n = 134, respectively [means +/- SE]; P = 0.051). Our findings suggest a role for Arg(972) IRS-1 in conferring risk for the development of type 1 diabetes...
  6. ncbi The strange case of G972R IRS-1 variant and diabetes. Do type 1 and type 2 diabetes share common genes?
    Massimo Federici
    Department of Internal Medicine, Center for Atherosclerosis and Laboratory of Molecular Medicine, University of Rome Tor Vergata, Rome, Italy
    Mol Genet Metab 81:261-2. 2004
  7. pmc TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice
    Rossella Menghini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Diabetes 61:454-62. 2012
    ..Our data show that macrophage-specific overexpression of TIMP3 protects from metabolic inflammation and related metabolic disorders such as insulin resistance, glucose intolerance, and nonalcoholic steatohepatitis...
  8. pmc Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness
    Marina Cardellini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Diabetes 60:3265-70. 2011
    ....
  9. doi Overexpression of tissue inhibitor of metalloproteinase 3 in macrophages reduces atherosclerosis in low-density lipoprotein receptor knockout mice
    Viviana Casagrande
    Department of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Arterioscler Thromb Vasc Biol 32:74-81. 2012
    ....
  10. ncbi The common Arg972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets
    M Federici
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome-'Tor Vergata, 00133 Rome, Italy
    FASEB J 15:22-24. 2001
    ..These findings establish an important role for the insulin signaling in human b-cell survival and suggest that genetic defects in early steps of insulin signaling may contribute to b-cell failure...
  11. ncbi Increased abundance of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of obese subjects is correlated with in vivo insulin sensitivity
    M Federici
    Department of Internal Medicine, University of Rome-Tor Vergata, Italy
    J Clin Endocrinol Metab 83:2911-5. 1998
    ..67; P < 0.016). These results indicate that downregulation of insulin receptors or upregulation of type 1 IGF receptors because of changes in plasma insulin and IGF-I levels may result in modifications in hybrid receptor abundance...
  12. ncbi The sulfonylurea glimepiride regulates intracellular routing of the insulin-receptor complexes through their interaction with specific protein kinase C isoforms
    M L Hribal
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome-Tor Vergata, Rome-Italy
    Mol Pharmacol 59:322-30. 2001
    ..These data suggest a novel mechanism of action of sulfonylurea, which may have a therapeutic impact on the treatment of type 2 diabetes...
  13. ncbi Molecular and functional characterization of pituitary adenylate cyclase-activating polypeptide (PACAP-38)/vasoactive intestinal polypeptide receptors in pancreatic beta-cells and effects of PACAP-38 on components of the insulin secretory system
    P Borboni
    Department of Internal Medicine, University of Rome Tor Vergata, Italy
    Endocrinology 140:5530-7. 1999
    ..Furthermore, we have demonstrated that PACAP exerts long-term effects on beta-cells, such as transcriptional regulation of the insulin gene and genes of the glucose-sensing system (GLUT1 and hexokinase 1)...
  14. ncbi The -866A/A genotype in the promoter of the human uncoupling protein 2 gene is associated with insulin resistance and increased risk of type 2 diabetes
    Monica D'Adamo
    Laboratory of Molecular Medicine, University of Rome, Rome, Italy
    Diabetes 53:1905-10. 2004
    ..84, 95% CI 1.03-3.28; P = 0.037), but not in men. These results indicate that the -866A/A genotype of the UCP2 gene may contribute to diabetes susceptibility by affecting insulin sensitivity...
  15. ncbi NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro
    D Pierucci
    Laboratory Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Diabetologia 44:1281-95. 2001
    ....
  16. ncbi Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes
    C Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Invest Dermatol 115:81-7. 2000
    ..As a whole, the results indicate that interleukin-17 can participate relevantly in T-cell-mediated skin immune responses by amplifying both interferon-gamma- and interleukin-4-induced activation of keratinocytes...
  17. ncbi Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells
    Cristina D'Alessandris
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    FASEB J 18:959-61. 2004
    ..Increased routing of glucose through this metabolic pathway results in impaired activation of the IR/IRSs/PI3-kinase/Akt survival pathway by induction of O-glycosylation of signaling molecules...
  18. pmc Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects
    M Federici
    Department of Internal Medicine, University of Rome, Tor Vergata, Italy
    J Clin Invest 98:2887-93. 1996
    ..Because IGF-I has been proposed as a hypoglycemic agent in NIDDM, these results are relevant to the development of new approaches to the treatment of insulin resistance of NIDDM...
  19. ncbi The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells
    M L Hribal
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    J Clin Endocrinol Metab 85:2004-13. 2000
    ..The present data indicate that the polymorphism at codon 972 of IRS-1 may contribute to the in vivo insulin resistance observed in carriers of this variant...
  20. ncbi Review article: diabetes and atherosclerosis--running on a common road
    M Federici
    Department of Internal Medicine, Center for Atherosclerosis and Laboratory of Molecular Medicine, University of Rome Tor Vergata, Rome, Italy
    Aliment Pharmacol Ther 22:11-5. 2005
    ..In conclusion, type 2 diabetes and atherosclerosis share vascular homeostasis and glucose metabolism and insulin resistance might be the common road where diabetes and atherosclerosis run together...
  21. ncbi Ligand activation of nerve growth factor receptor TrkA protects monocytes from apoptosis
    A la Sala
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Leukoc Biol 68:104-10. 2000
    ..In addition, during in vitro monocyte to dendritic cell differentiation TrkA expression is progressively lost, suggesting that NGF selectively affects monocyte but not dendritic cell survival...
  22. ncbi Increased abundance of insulin/IGF-I hybrid receptors in adipose tissue from NIDDM patients
    M Federici
    Department of Internal Medicine, University of Rome-Tor Vergata, Italy
    Mol Cell Endocrinol 135:41-7. 1997
    ....
  23. ncbi Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient
    Francesca Bernassola
    Biochemistry Laboratory, IDI IRCCS, Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    FASEB J 16:1371-8. 2002
    ..Collectively, these results identify TGase 2 as a potential candidate gene in type 2 diabetes...
  24. ncbi Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis
    Rossella Menghini
    Department of Internal Medicine, University of Rome Tor Vergata, Policlinico Tor Vergata PTV University Hospital, Rome, Italy
    Circulation 111:1946-53. 2005
    ..GATA2 transcription factor is an inhibitor of adipogenesis and an activator of vascular cells. We hypothesized that GATA2 activity is controlled by insulin during adipogenesis, linking metabolic homeostasis and inflammation...
  25. doi Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice
    Rossella Menghini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Gastroenterology 136:663-72.e4. 2009
    ....
  26. ncbi Chronic hyperglycemia impairs insulin secretion by affecting insulin receptor expression, splicing, and signaling in RIN beta cell line and human islets of Langerhans
    Marta L Hribal
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    FASEB J 17:1340-2. 2003
    ..These data suggest that changes in early steps of insulin receptor signaling may play a role in determining beta-cell dysfunction caused by chronic hyperglycemia...
  27. ncbi Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesity
    C Serra
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Rome, Italy
    J Cell Physiol 196:89-97. 2003
    ....
  28. doi "The Linosa Study": epidemiological and heritability data of the metabolic syndrome in a Caucasian genetic isolate
    A Bellia
    Department of Internal Medicine, University of Rome Tor Vergata, I 00133 Rome, Italy
    Nutr Metab Cardiovasc Dis 19:455-61. 2009
    ....
  29. ncbi Inhibition of catechol-O-methyltransferase (COMT) in the brain does not affect the action of dopamine and levodopa: an in vitro electrophysiological evidence from rat mesencephalic dopamine neurons
    N B Mercuri
    IRCCS Santa Lucia and Clinica Neurologica, Universita di Tor Vergata, Roma, Italy
    J Neural Transm 106:1135-40. 1999
    ..Therefore, the therapeutic action of tolcapone in Parkinson's disease, might be dependent on the reduction of COMT activity in the extracerebral tissue...
  30. ncbi Tranylcypromine, but not moclobemide, prolongs the inhibitory action of dopamine on midbrain dopaminergic neurons: an in vitro electrophysiological study
    N B Mercuri
    IRCCS Santa Lucia and Clinica Neurologica, Universita di Tor Vergata, Roma, Italy
    Synapse 37:216-21. 2000
    ..The phenomena reported above support the hypothesis that part of the antidepressant and antiparkinsonian effects of tranylcypromine depend on an action on DA transmission...
  31. ncbi Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms
    G Sesti
    University of Catanzaro Magna, Graecia, Italy
    Diabetes Metab Res Rev 17:363-73. 2001
    ....
  32. ncbi Mice heterozygous for tumor necrosis factor-alpha converting enzyme are protected from obesity-induced insulin resistance and diabetes
    Matteo Serino
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Diabetes 56:2541-6. 2007
    ..The role of TACE in high-fat diet (HFD)-induced obesity and its metabolic complications is unknown...
  33. pmc Mandibuloacral dysplasia is caused by a mutation in LMNA-encoding lamin A/C
    Giuseppe Novelli
    Department of Biopathology and Diagnostic Imaging, Faculty for Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133 Romea, Italy
    Am J Hum Genet 71:426-31. 2002
    ..Patient skin fibroblasts showed nuclei that presented abnormal lamin A/C distribution and a dysmorphic envelope, thus demonstrating the pathogenic effect of the R527H LMNA mutation...
  34. ncbi Relationship between plasma free fatty acids and uncoupling protein-3 gene expression in skeletal muscle of obese subjects: in vitro evidence of a causal link
    Paolo Sbraccia
    Loboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, Italy
    Clin Endocrinol (Oxf) 57:199-207. 2002
    ....
  35. ncbi Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online
    O Porzio
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Hum Mutat 28:1150. 2007
    ..We conclude that reduced TG2 activity can contribute to disorders of glucose metabolism possibly via an impairment of insulin secretion...
  36. pmc Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes
    Stefano Rizza
    Center for Atherosclerosis Policlinico Tor Vergata University Hospital, Internal Medicine Department, Rome, Italy
    Atherosclerosis 206:569-74. 2009
    ..Therefore, in the present study, we tested the hypothesis that dietary supplementation with fish oil rich in n-3 PUFA may improve ED in otherwise healthy OPDs...
  37. ncbi IL12B polymorphism and type 1 diabetes in the Italian population: a case-control study
    Lorenza Nisticò
    Institute of Cell Biology, CNR, Campus Buzzati Traverso, Monterotondo, Rome, Italy
    Diabetes 51:1649-50. 2002
    ..We analyzed the same polymorphism in 470 Italian type 1 diabetic patients and 544 matched control subjects and found no evidence of association with the disease...
  38. ncbi The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients
    Maria Adelaide Marini
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    J Clin Endocrinol Metab 88:3368-71. 2003
    ..These results suggest that the Arg(972) IRS-1 variant could contribute to the risk for atherosclerotic cardiovascular diseases associated with type 2 diabetes by producing a cluster of insulin resistance-related metabolic abnormalities...
  39. ncbi Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes
    Rossella D'Alfonso
    Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    J Clin Endocrinol Metab 88:317-22. 2003
    ..These results strongly argue against a major role of IRS-2 polymorphisms in the pathogenesis of type 2 diabetes...
  40. doi High mobility group box 1 is a novel substrate of dipeptidyl peptidase-IV
    C Marchetti
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Diabetologia 55:236-44. 2012
    ..Since HMGB1 contains potential DPP-IV cleavage sites, we determined whether HMGB1 may be a substrate for DPP-IV and whether DPP-IV-mediated cleavage may alter the biological activity of HMGB1...
  41. ncbi A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases
    C Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Leukoc Biol 70:617-23. 2001
    ..Thus, keratinocytes appear considerably more sensitive to Th1- than to Th2-derived lymphokines in terms of chemokine release and can support the preferential accumulation of Th1 lymphocytes in the skin...
  42. pmc TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1
    Marina Cardellini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Diabetes 58:2396-401. 2009
    ..We tested its association with atherosclerosis in subjects with type 2 diabetes and identified Sirtuin 1 (SirT1) as a major regulator of TIMP3 expression...
  43. doi Adiponectin isoforms in elderly patients with or without coronary artery disease
    Stefano Rizza
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    J Am Geriatr Soc 58:702-6. 2010
    ..To study the distribution of adiponectin isoforms in a group of very old patients...
  44. doi Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice
    Loredana Fiorentino
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Hepatology 51:103-10. 2010
    ..Conclusion: We have identified novel mechanisms, governed by the TACE-Timp3 interaction, involved in the determination of insulin resistance and liver steatosis during overfeeding in mice...
  45. doi Occult impaired glucose regulation in patients with atherosclerosis is associated to the number of affected vascular districts and inflammation
    Stefano Rizza
    Department of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Atherosclerosis 212:316-20. 2010
    ....
  46. doi Accelerated lipid-induced atherogenesis in galectin-3-deficient mice: role of lipoxidation via receptor-mediated mechanisms
    Carla Iacobini
    Department of Clinical Sciences, La Sapienza University, Rome, Italy
    Arterioscler Thromb Vasc Biol 29:831-6. 2009
    ..Disposal of these particles is mediated through receptors which may trigger proinflammatory signaling pathways leading to vascular injury. This study was aimed at assessing the role in atherogenesis of one of these receptors, galectin-3...
  47. doi Adiponectin isoforms are not associated with the severity of coronary atherosclerosis but with undiagnosed diabetes in patients affected by stable CAD
    Stefano Rizza
    Center for Atherosclerosis, University of Rome Tor Vergata, Rome, Italy
    Nutr Metab Cardiovasc Dis 19:54-60. 2009
    ..We investigated the role of adiponectin isoforms with respect to the severity of coronary disease and to the presence of undiagnosed diabetes in patients with CAD...
  48. doi Metabolic syndrome and risk of pulmonary involvement
    Paola Rogliani
    Department of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Respir Med 104:47-51. 2010
    ..Mainly abdominal circumference, and also insulin resistance were retained as independent predictors of both FEV(1) and FVC changes. However, HDL-C was the strongest predictor of FEV(1) and FVC changes, with an inverse association...
  49. ncbi Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling
    Valentina Marchetti
    Department of Internal Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Diabetes 55:2231-7. 2006
    ..Our results indicate that hyperglycemia impairs EPC differentiation and that the process can be restored by benfotiamine administration, via the modulation of Akt/FoxO1 activity...
  50. doi Insulin resistance affects gene expression in endothelium
    Claudia Consoli
    Arterioscler Thromb Vasc Biol 28:e7-9. 2008
  51. ncbi G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells
    Massimo Federici
    Department of Medicine and Aging Sciences, Edificio CeSi, Room 271, University of Chieti, Via dei Vestini, 1, 66100 Chieti, Italy
    Circulation 109:399-405. 2004
    ....
  52. ncbi Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells
    Francesco Andreozzi
    Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Via Tommaso Campanella, 115, 88100 Catanzaro, Italy
    Endocrinology 145:2845-57. 2004
    ..These changes result in impaired coupling of IRS-1 and PI 3-kinase, and activation of the Akt/mammalian target of rapamycin/phosphorylated heat- and acid-stable protein-1/p70S6 kinase pathway...
  53. ncbi The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia di Catanzaro Via Tommaso Campanella, 115 88100 Catanzaro, Italy
    Diabetes Care 27:1394-8. 2004
    ..The aim of this study was to investigate whether diabetic patients carrying the Arg(972) insulin receptor substrate-1 (IRS-1) variant are at increased risk for secondary failure to sulfonylurea...
  54. ncbi Impaired endothelial function in never-treated hypertensive subjects carrying the Arg972 polymorphism in the insulin receptor substrate-1 gene
    Francesco Perticone
    Department of Experimental and Clinical Medicine, G Salvatore University Magna Graecia of Catanzaro, Policlinico Mater Domini Via Tommaso Campanella, 88100 Catanzaro, Italy
    J Clin Endocrinol Metab 89:3606-9. 2004
    ..4 vs. 13.3 +/- 3.5 ml/100 ml(-1) of tissue per min(-1)). Our data strongly suggest that, by inducing endothelial dysfunction, the Arg(972) IRS-1 polymorphism may contribute to the genetic predisposition to develop cardiovascular disease...
  55. ncbi Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism
    Piero Marchetti
    Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
    Diabetes 51:1419-24. 2002
    ..These alterations may account for the increased predisposition to type 2 diabetes in individuals carrying the Gly(972)-->Arg amino acid polymorphism of IRS-1...
  56. ncbi A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects
    Giorgio Sesti
    Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Via Tommaso Campanella, 115 11800 Catanzaro, Italy
    Diabetes 52:1280-3. 2003
    ..These results indicate that the common -866G/A polymorphism in the UCP2 gene may contribute to the biological variation of insulin secretion in humans...
  57. ncbi Carotid artery intima-media thickness is associated with insulin-mediated glucose disposal in nondiabetic normotensive offspring of type 2 diabetic patients
    Marina Cardellini
    Dipartimento di Medicina Sperimentale e Clinica, Policlinico Universitario Mater Domini, Via Europa, Campus Germaneto, 88100 Catanzaro, Italy
    Am J Physiol Endocrinol Metab 292:E347-52. 2007
    ..7% of its variation. These findings support the concept that insulin sensitivity, rather than plasma insulin levels, is associated with early atherosclerosis in nondiabetic normotensive offspring of type 2 diabetic patients...
  58. ncbi Endothelial function and arterial stiffness in normotensive normoglycemic first-degree relatives of diabetic patients are independent of the metabolic syndrome
    Angelo Scuteri
    UO Geriatria, INRCA IRCCS, Via Cassia 1167, 00189 Rome, Italy
    Nutr Metab Cardiovasc Dis 18:349-56. 2008
    ....
  59. ncbi Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance
    Giorgio Sesti
    Department of Experimental and Clinical Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
    Diabetes Care 28:120-5. 2005
    ..We studied the relationships between plasma IGF-I concentrations and insulin sensitivity in subjects with various degrees of glucose tolerance...
  60. ncbi Insulin resistance and increased intimal medial thickness in glucose tolerant offspring of type 2 diabetic subjects carrying the D298D genotype of endothelial nitric oxide synthase
    Stefano Rizza
    Arterioscler Thromb Vasc Biol 26:431-2. 2006
  61. doi Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome
    Mirella Fiorito
    CSS Mendel Institute, viale Regina Margherita, 261, 00198 Roma, Italy
    Obesity (Silver Spring) 15:2889-95. 2007
    ..If confirmed in other populations, comprising several thousand individuals, these data may help identify individuals at risk for insulin resistance-related abnormalities...