Alberto Falorni

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. pmc Pharmacological causes of hyperprolactinemia
    Daria La Torre
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia Perugia, Italy
    Ther Clin Risk Manag 3:929-51. 2007
  2. ncbi Humoral responses in type 1 diabetes mellitus
    Alberto Falorni
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Rev Endocr Metab Disord 4:281-90. 2003
  3. ncbi Diabetes-related antibodies in adult diabetic patients
    Alberto Falorni
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
    Best Pract Res Clin Endocrinol Metab 19:119-33. 2005
  4. ncbi [Immunologic and genetic aspects of latent autoimmune diabetes in the adult]
    A Falorni
    Dipartimento di Medicina Interna, Universita degli Studi di Perugia, Perugia
    Minerva Endocrinol 28:297-312. 2003
  5. ncbi Autoantibodies in autoimmune polyendocrine syndrome type II
    Alberto Falorni
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, 06126 Perugia, Italy
    Endocrinol Metab Clin North Am 31:369-89, vii. 2002
  6. ncbi Association of genetic polymorphisms and autoimmune Addison's disease
    Alberto Falorni
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, Via E dal Pozzo, 06126 Perugia, Italy
    Expert Rev Clin Immunol 4:441-56. 2008
  7. doi Cytotoxic T lymphocyte antigen-4 Ala17 polymorphism is a genetic marker of autoimmune adrenal insufficiency: Italian association study and meta-analysis of European studies
    Annalisa Brozzetti
    Section of Internal Medicine and Endocrine and Metabolic Sciences, Department of Internal Medicine, University of Perugia, Via Enrico Dal Pozzo, 06126 Perugia, Italy
    Eur J Endocrinol 162:361-9. 2010
  8. ncbi Autoantibody responses in autoimmune ovarian insufficiency and in Addison's disease are IgG1 dominated and suggest a predominant, but not exclusive, Th1 type of response
    Annalisa Brozzetti
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Eur J Endocrinol 163:309-17. 2010
  9. doi Measuring adrenal autoantibody response: interlaboratory concordance in the first international serum exchange for the determination of 21-hydroxylase autoantibodies
    Alberto Falorni
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, 06126 Perugia, Italy
    Clin Immunol 140:291-9. 2011
  10. ncbi Retrovirus-like long-terminal repeat DQ-LTR13 and genetic susceptibility to type 1 diabetes and autoimmune Addison's disease
    Giovanni Gambelunghe
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
    Diabetes 54:900-5. 2005

Detail Information

Publications49

  1. pmc Pharmacological causes of hyperprolactinemia
    Daria La Torre
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia Perugia, Italy
    Ther Clin Risk Manag 3:929-51. 2007
    ....
  2. ncbi Humoral responses in type 1 diabetes mellitus
    Alberto Falorni
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Rev Endocr Metab Disord 4:281-90. 2003
  3. ncbi Diabetes-related antibodies in adult diabetic patients
    Alberto Falorni
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
    Best Pract Res Clin Endocrinol Metab 19:119-33. 2005
    ..GADA assay should be offered to every diabetic patient, and in cases of positivity screening for other autoimmune diseases should be carried out...
  4. ncbi [Immunologic and genetic aspects of latent autoimmune diabetes in the adult]
    A Falorni
    Dipartimento di Medicina Interna, Universita degli Studi di Perugia, Perugia
    Minerva Endocrinol 28:297-312. 2003
    ....
  5. ncbi Autoantibodies in autoimmune polyendocrine syndrome type II
    Alberto Falorni
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, 06126 Perugia, Italy
    Endocrinol Metab Clin North Am 31:369-89, vii. 2002
    ..Screening for other organ-specific autoimmune diseases should be performed in every patient with at least one major disease component of APS-II...
  6. ncbi Association of genetic polymorphisms and autoimmune Addison's disease
    Alberto Falorni
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, Via E dal Pozzo, 06126 Perugia, Italy
    Expert Rev Clin Immunol 4:441-56. 2008
    ..Other gene polymorphisms contributing to genetic risk for AAD are MHC2TA, the gene coding for class II transactivator, the master regulator of class II expression, cytotoxic T lymphocyte antigen-4, PTPN22 and the vitamin D receptor...
  7. doi Cytotoxic T lymphocyte antigen-4 Ala17 polymorphism is a genetic marker of autoimmune adrenal insufficiency: Italian association study and meta-analysis of European studies
    Annalisa Brozzetti
    Section of Internal Medicine and Endocrine and Metabolic Sciences, Department of Internal Medicine, University of Perugia, Via Enrico Dal Pozzo, 06126 Perugia, Italy
    Eur J Endocrinol 162:361-9. 2010
    ..We tested the human leukocyte antigen (HLA)-independent association of CTLA4+49 (A/G) (Ala 17) and/or CTLA4 CT60 (A/G) polymorphism with AAD...
  8. ncbi Autoantibody responses in autoimmune ovarian insufficiency and in Addison's disease are IgG1 dominated and suggest a predominant, but not exclusive, Th1 type of response
    Annalisa Brozzetti
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Eur J Endocrinol 163:309-17. 2010
    ..The aim of the study was to analyze IgG subclass specificity of autoantibodies related to adrenal and ovarian autoimmunity...
  9. doi Measuring adrenal autoantibody response: interlaboratory concordance in the first international serum exchange for the determination of 21-hydroxylase autoantibodies
    Alberto Falorni
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, 06126 Perugia, Italy
    Clin Immunol 140:291-9. 2011
    ..A standardization international program for 21OHAb measurement is strongly needed...
  10. ncbi Retrovirus-like long-terminal repeat DQ-LTR13 and genetic susceptibility to type 1 diabetes and autoimmune Addison's disease
    Giovanni Gambelunghe
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
    Diabetes 54:900-5. 2005
    ..We provide conclusive evidence that the genetic association of DQ-LTR13 with type 1 diabetes and AAD is primarily due to a LD with DQB1*0302 and DRB1*0403...
  11. ncbi Corticotrope hypersecretion coupled with cortisol hypo-responsiveness to stimuli is present in patients with autoimmune endocrine diseases: evidence for subclinical primary hypoadrenalism?
    Roberta Giordano
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Turin, Ospedale Molinette, C so Dogliotti 14 10126 Turin, Italy
    Eur J Endocrinol 155:421-8. 2006
    ..We investigated the function of the hypothalamic-pituitary-adrenal axis in a group of patients with autoimmune diseases (AP) without any symptoms and signs of hypoadrenalism...
  12. ncbi Mapping of human autoantibody epitopes on aromatic L-amino acid decarboxylase
    Paola Candeloro
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, Via E dal Pozzo, 06126 Perugia, Italy
    J Clin Endocrinol Metab 92:1096-105. 2007
    ..Little information is currently available on AADC autoantibody epitopes and on the interrelation between autoantibody-mediated inhibition of enzymatic activity and epitope specificity...
  13. doi Progressive decline of residual follicle pool after clinical diagnosis of autoimmune ovarian insufficiency
    Alberto Falorni
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy
    Clin Endocrinol (Oxf) 77:453-8. 2012
    ..Anti-müllerian hormone (AMH) is the best marker of the residual follicular pool...
  14. ncbi Italian addison network study: update of diagnostic criteria for the etiological classification of primary adrenal insufficiency
    Alberto Falorni
    Department of Internal Medicine, University of Perugia, 06126 Perugia, Italy
    J Clin Endocrinol Metab 89:1598-604. 2004
    ..Lastly, we developed a comprehensive flowchart for the classification of PAI for use in routine clinical practice...
  15. ncbi CTLA-4-Ig regulates tryptophan catabolism in vivo
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 3:1097-101. 2002
    ..These data suggest that modulation of tryptophan catabolism is a means by which CTLA-4 functions in vivo and that CTLA-4 acts as a ligand for B7 receptor molecules that transduce intracellular signals...
  16. ncbi CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults
    Anna Cosentino
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy
    Ann N Y Acad Sci 958:337-40. 2002
    ..028). The results of our study show that LADA is positively associated with the CTLA-4 A/G genotype, similarly to T1DM, thus providing further supporting evidence of the autoimmune origin of this form of diabetes mellitus of the adult...
  17. ncbi Diagnosis and classification of autoimmune hypophysitis
    Alberto Falorni
    Section of Internal Medicine and Endocrine and Metabolic Sciences, Italy
    Autoimmun Rev 13:412-6. 2014
    ....
  18. doi Therapy of adrenal insufficiency: an update
    Alberto Falorni
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Via E dal Pozzo, Perugia, 06126, Italy
    Endocrine 43:514-28. 2013
    ..Future clinical trials of immunomodulation or immunoprevention will test the possibility to delay (or prevent) the autoimmune destruction of the adrenal gland in autoimmune Addison's disease...
  19. ncbi Steroid-cell autoantibodies are preferentially expressed in women with premature ovarian failure who have adrenal autoimmunity
    Alberto Falorni
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Fertil Steril 78:270-9. 2002
    ..To determine the prevalence of steroid-cell autoantibodies, 3beta-hydroxysteroid dehydrogenase (3beta-HSD) antibodies, 17alpha-hydroxylase (17alpha-OH) antibodies, and P450 side-chain cleavage antibodies in premature ovarian failure...
  20. ncbi MICA A8: a new allele within MHC class I chain-related A transmembrane region with eight GCT repeats
    Giovanni Gambelunghe
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, Perugia, Italy
    Hum Immunol 67:1005-7. 2006
    ..We named this allele, as a current nomenclature, MICA8...
  21. ncbi Dehydroepiandrosterone, 17alpha-hydroxyprogesterone and aldosterone responses to the low-dose (1 micro g) ACTH test in subjects with preclinical adrenal autoimmunity
    Stefano Laureti
    Department of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Italy
    Clin Endocrinol (Oxf) 57:677-83. 2002
    ....
  22. ncbi BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas
    Efisio Puxeddu
    Dipartimento di Medicina Interna, Universita di Perugia, Perugia
    J Clin Endocrinol Metab 89:2414-20. 2004
    ....
  23. ncbi Expression of endocrine autoantibodies in chronic hepatitis C, before and after interferon-alpha therapy
    G Murdolo
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences DI M I S E M, University of Perugia, Perugia, Italy
    J Endocrinol Invest 25:938-46. 2002
    ..Furthermore, we demonstrate that IFN-alpha treatment is associated with the induction or enhancement of thyroid, but not of islet-cell or adrenal cortex autoimmunity...
  24. ncbi Low dose (1 microg) ACTH test in the evaluation of adrenal dysfunction in pre-clinical Addison's disease
    S Laureti
    Department of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Italy
    Clin Endocrinol (Oxf) 53:107-15. 2000
    ..The aim of our study was to evaluate the clinical use of the LDT in the diagnosis of early adrenocortical dysfunction in patients with adrenal autoantibodies...
  25. ncbi Improvement of treatment of primary adrenal insufficiency by administration of cortisone acetate in three daily doses
    S Laureti
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy
    J Endocrinol Invest 26:1071-5. 2003
    ..Our study demonstrates that the subdivision of the total daily dose of cortisone acetate in 3 administrations increases total UFC excretion and reduces plasma ACTH levels, thus improving the substitutive therapy...
  26. ncbi Etiological diagnosis of primary adrenal insufficiency using an original flowchart of immune and biochemical markers
    S Laureti
    Department of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Italy
    J Clin Endocrinol Metab 83:3163-8. 1998
    ..The results of our study have important therapeutic and prognostic implications...
  27. ncbi Addison's disease
    Stefania Marzotti
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy
    Autoimmunity 37:333-6. 2004
  28. ncbi Autoantibody profile and epitope mapping in latent autoimmune diabetes in adults
    Alberto Falorni
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Perugia, Italy
    Ann N Y Acad Sci 958:99-106. 2002
    ..LADA should be considered a major component of the autoimmune polyendocrine syndromes, and screening for other autoimmune diseases should be performed in all LADA patients...
  29. doi Can NK cells be a therapeutic target in human type 1 diabetes?
    Francesco Dotta
    Diabetes Unit, Department of Internal Medicine, Endocrine and Metabolic Sciences and Biochemistry, University of Siena, Siena, Italy
    Eur J Immunol 38:2961-3. 2008
    ....
  30. pmc Inflammatory adipokines, high molecular weight adiponectin, and insulin resistance: a population-based survey in prepubertal schoolchildren
    Giuseppe Murdolo
    Section of Internal Medicine, Endocrine and Metabolic Sciences, Department of Internal Medicine, Perugia University, Perugia, Italy
    PLoS ONE 6:e17264. 2011
    ....
  31. ncbi Adrenal sensitivity to adrenocorticotropin 1-24 is reduced in patients with autoimmune polyglandular syndrome
    R Giordano
    Division of Endocrinology, Department of Internal Medicine, University of Turin, Turin, Italy
    J Clin Endocrinol Metab 89:675-80. 2004
    ..These data are likely to indicate that a reduced sensitivity to ACTH in all adrenal zones occurs in patients with different types of autoimmune disease...
  32. doi Number of autoantibodies and HLA genotype, more than high titers of glutamic acid decarboxylase autoantibodies, predict insulin dependence in latent autoimmune diabetes of adults
    M Maioli
    Department of Internal Medicine, University of Sassari, Sassari, Italy
    Eur J Endocrinol 163:541-9. 2010
    ..In this study, we searched for sensitive markers associated with early development of insulin dependence...
  33. pmc Age-period-cohort analysis of 1990-2003 incidence time trends of childhood diabetes in Italy: the RIDI study
    Graziella Bruno
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes 59:2281-7. 2010
    ..To investigate age-period-cohort effects on the temporal trend of type 1 diabetes in children age 0-14 years in Italian registries...
  34. ncbi Circulating acylated and total ghrelin and galanin in children with insulin-treated type 1 diabetes: relationship to insulin therapy, metabolic control and pubertal development
    F Celi
    Department of Gynaecological, Obstetric and Paediatric Sciences, University of Perugia, Italy
    Clin Endocrinol (Oxf) 63:139-45. 2005
    ..To study the circulating levels of two gut-derived peptides in children with type 1 (insulin-dependent) diabetes mellitus (IDDM)...
  35. ncbi Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse
    F Calcinaro
    Department of Internal Medicine, University of Perugia, Italy
    Diabetologia 48:1565-75. 2005
    ....
  36. ncbi MICA gene polymorphism in the pathogenesis of type 1 diabetes
    G Gambelunghe
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
    Ann N Y Acad Sci 1110:92-8. 2007
    ..The polymorphism of the MICA gene is associated with T1DM in different populations as demonstrated in several papers published in the last 7 years...
  37. ncbi Lack of association of human chemokine receptor gene polymorphisms CCR2-64I and CCR5-Delta32 with autoimmune Addison's disease
    G Gambelunghe
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Eur J Immunogenet 31:73-6. 2004
    ..Our results indicate that the CCR2-64I and CCR5-Delta32 gene polymorphisms do not play a major role in conferring genetic risk for, and/or protection against, autoimmune Addison's disease...
  38. ncbi Circulating adipocytokines in non-diabetic and Type 1 diabetic children: relationship to insulin therapy, glycaemic control and pubertal development
    F Celi
    Department of Medical Surgical Specialties and Public Health, Section of Paediatrics, University of Perugia, Perugia, Italy
    Diabet Med 23:660-5. 2006
    ..To determine the influence of Type 1 diabetes mellitus on circulating adipocytokines in children...
  39. ncbi Two distinct MICA gene markers discriminate major autoimmune diabetes types
    G Gambelunghe
    Department of Internal Medicine, University of Perugia, 06126 Perugia, Italy
    J Clin Endocrinol Metab 86:3754-60. 2001
    ..1, respectively...
  40. doi Identification of tyrosine phosphatase 2(256-760) construct as a new, sensitive marker for the detection of islet autoimmunity in type 2 diabetic patients: the non-insulin requiring autoimmune diabetes (NIRAD) study 2
    Claudio Tiberti
    Department of Clinical Sciences, University of Rome La Sapienza, Rome, Italy
    Diabetes 57:1276-83. 2008
    ....
  41. ncbi Improved in planta expression of the human islet autoantigen glutamic acid decarboxylase (GAD65)
    Linda Avesani
    Dipartimento Scientifico e Tecnologico, Universita degli Studi di Verona, Strada Le Grazie 15, 37134, Verona, Italy
    Transgenic Res 12:203-12. 2003
    ..This substantial improvement of the expression of hGAD65 in plants paves the way for immunoprevention studies of oral administration of GAD65-containing transgenic plant material in animal models of spontaneous autoimmune diabetes...
  42. doi High serum inhibin concentration discriminates autoimmune oophoritis from other forms of primary ovarian insufficiency
    Anastasia Tsigkou
    Department of Pediatrics, Obstetrics, and Reproductive Medicine, Universityof Siena, Siena, Italy
    J Clin Endocrinol Metab 93:1263-9. 2008
    ..Primary ovarian insufficiency (POI) is defined by hypergonadotropic amenorrhea occurring before the age of 40 yr. In 4-5% of women with POI, an ovarian autoimmune process can be demonstrated...
  43. ncbi Screening for type 1 diabetes genetic risk in newborns of continental Italy. Primary prevention (Prevefin Italy)--preliminary data
    Renata Lorini
    Dept of Pediatrics, G Gaslini Institute, Genoa, Italy
    Acta Biomed 76:31-5. 2005
  44. ncbi Lack of association of CCR2-64I and CCR5-Delta 32 with type 1 diabetes and latent autoimmune diabetes in adults
    Giovanni Gambelunghe
    Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Hum Immunol 64:629-32. 2003
    ..In the present study, we demonstrate the lack of association between CCR2-64I and CCR5-Delta 32 gene polymorphism and TIDM and we describe a new method for a simple and more precise genotyping of the CCR2 gene...
  45. ncbi The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with high GAD antibody titer in latent autoimmune diabetes in adults: Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study 3
    Antonio Petrone
    Department of Clinical Science, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Rome, Italy
    Diabetes Care 31:534-8. 2008
    ..The aim of the present study was to evaluate whether the phenotypic heterogeneity of adult-onset autoimmune diabetes based on the GADA titer is associated with the PTPN22 C1858T polymorphism...
  46. ncbi MHC2TA single nucleotide polymorphism and genetic risk for autoimmune adrenal insufficiency
    Mehran Ghaderi
    Department of Clinical Pathology and Cytology, Karolinska University Hospital, SE 141 86 Stockholm, Sweden
    J Clin Endocrinol Metab 91:4107-11. 2006
    ..The MHC2TA -168 A-->G single nucleotide polymorphism (rs3087456) has been suggested to confer susceptibility to some autoimmune diseases...
  47. ncbi Diabetes incidence in 0- to 14-year age-group in Italy: a 10-year prospective study
    Flavia Carle
    Department of Pediatrics, Polytechnic University of Marche Via Corridoni, 11 I 60123 Ancona, Italy
    Diabetes Care 27:2790-6. 2004
    ..This report is based on 3,606 children younger than 15 years diagnosed with type 1 diabetes and prospectively registered during 1990-1999 by nine centers, covering >35% of the Italian population...
  48. ncbi Elevated serum interferon-gamma-inducible chemokine-10/CXC chemokine ligand-10 in autoimmune primary adrenal insufficiency and in vitro expression in human adrenal cells primary cultures after stimulation with proinflammatory cytokines
    Mario Rotondi
    Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, V le Pieraccini 6, 50139 Firenze, Italy
    J Clin Endocrinol Metab 90:2357-63. 2005
    ..Taken together, these data suggest a potential role of hZFC, through the production of CXCL10, in regulating the recruitment of specific subsets of activated lymphocytes in autoimmune AD...
  49. ncbi Selective theca cell dysfunction in autoimmune oophoritis results in multifollicular development, decreased estradiol, and elevated inhibin B levels
    Corrine K Welt
    Reproductive Endocrine Unit, Department of Medicine, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:3069-76. 2005
    ..In addition, the normal inhibin A and inhibin B production in the absence of estradiol precursors and estradiol provide insight into the selective dysfunction of the theca cells in autoimmune oophoritis...