Affiliation: University of Perugia
Falini B, Bolli N, Shan J, Martelli M, Liso A, Pucciarini A, et al
. Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. Blood. 2006;107:4514-23 pubmed
..These findings indicate that potential therapeutic strategies aimed to retarget NPM to its physiological sites will have to overcome 2 obstacles, the new NES motif and the mutated tryptophan(s) at the NPM mutant C-terminus. ..
Falini B, Nicoletti I, Bolli N, Martelli M, Liso A, Gorello P, et al
. Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias. Haematologica. 2007;92:519-32 pubmed
..The discovery of NPM1 gene alterations also represents the rationale basis for development of molecular targeted drugs. ..
Falini B, Mecucci C, Saglio G, Lo Coco F, Diverio D, Brown P, et al
. NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia. Haematologica. 2008;93:439-42 pubmed publisher
..Taken together, these findings make NPMc+ acute myeloid leukemia a good candidate for inclusion in the upcoming World Health Organization classification...
Falini B, Fizzotti M, Pucciarini A, Bigerna B, Marafioti T, Gambacorta M, et al
. A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells. Blood. 2000;95:2084-92 pubmed
..These results suggest that MUM1 is involved in the late stages of B-cell differentiation and in T-cell activation and is deregulated in DLCL-B. (Blood. 2000;95:2084-2092) ..
Falini B, Martelli M, Bolli N, Bonasso R, Ghia E, Pallotta M, et al
. Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia. Blood. 2006;108:1999-2005 pubmed
Falini B, Tiacci E, Liso A, Basso K, Sabattini E, Pacini R, et al
. Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1). Lancet. 2004;363:1869-70 pubmed
Falini B, Bolli N, Liso A, Martelli M, Mannucci R, Pileri S, et al
. Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications. Leukemia. 2009;23:1731-43 pubmed publisher
..Finally, we discuss the future therapeutic perspectives aimed at reversing the altered nucleophosmin transport in AML with mutated NPM1. ..
Falini B, Tiacci E, Pucciarini A, Bigerna B, Kurth J, Hatzivassiliou G, et al
. Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT). Blood. 2003;102:3684-92 pubmed
..Collectively, these results suggest a role of IRTA1 in the immune function of B cells within epithelia. ..
Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L, et al
. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med. 2005;352:254-66 pubmed
..Cytoplasmic NPM is a characteristic feature of a large subgroup of patients with AML who have a normal karyotype, NPM gene mutations, and responsiveness to induction chemotherapy. ..