Research Topics
| G FabbriniSummaryAffiliation: University of Rome La Sapienza Country: Italy Publications
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Publications
Levodopa-induced dyskinesiasGiovanni Fabbrini
Department of Neurological Sciences University of Rome La Sapienza, Rome, Italy
Mov Disord 22:1379-89; quiz 1523. 2007..New rating measures to assess severity and disability related to dyskinesia are in the process of development and clinimetric testing...
Soluble and controlled-release preparations of levodopa: do we really need them?Giovanni Fabbrini
Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
J Neurol 257:S292-7. 2010..New dual formulations incorporating both a faster absorption and an increased half-life than standard levodopa are currently under study...- Pramipexole in Parkinson's disease. A short-term study using the combined levodopa-dopamine agonist testGiovanni Fabbrini
Department of Neurosciences, University of Rome La Sapienza, Italy
Funct Neurol 17:199-201. 2002..The main effect of pramipexole in fluctuating parkinsonian patients is an increased duration of the on phase... - Tardive dyskinesias in the elderlyG Fabbrini
Department of Neurological Sciences, University La Sapienza, Rome, Italy
Int J Geriatr Psychiatry 16:S19-23. 2001..Data are accumulating to show that this is likely to be true also in older patients... - Epidemiology of progressive supranuclear palsy. ESGAP Consortium. European Study Group on Atypical ParkinsonismsN Vanacore
Department of Neurological Sciences, La Sapienza University, Rome, Italy
Neurol Sci 22:101-3. 2001..The significance of this association is still not clear. We have performed a case-control study on 58 PSP cases, 116 hospital controls and 58 population controls... - Increased expression of dopamine receptors on lymphocytes in Parkinson's diseaseP Barbanti
Department of Neurosciences, University La Sapienza, Rome, Italy
Mov Disord 14:764-71. 1999..The increased density of D1-like and D2-like receptors on PBL in de novo PD patients may represent an upregulation mechanism resulting from the diffuse impairment of the dopaminergic system in PD... - Lack of LTP-like plasticity in primary motor cortex in Parkinson's diseaseA Suppa
Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy
Exp Neurol 227:296-301. 2011..In PD patients with and without LIDs, on and off therapy iTBS fails to increase MEP responses. This finding suggests lack of iTBS-induced LTP-like plasticity in M1 in PD regardless of patients' clinical features... - Donepezil in the treatment of progressive supranuclear palsyG Fabbrini
Department of Neurological Sciences, University La Sapienza, Rome
Acta Neurol Scand 103:123-5. 2001..To evaluate the effect of 3 month therapy with donepezil, a centrally acting cholinesterase inhibitor, on cognitive performances, motor function and daily living activities in progressive supranuclear palsy (PSP)... - Reduced density of dopamine D2-like receptors on peripheral blood lymphocytes in Alzheimer's diseaseP Barbanti
Dipartimento di Scienze Neurologiche, Università La Sapienza 00161, Rome, Italy
Mech Ageing Dev 120:65-75. 2000..Our findings support the hypothesis of an involvement of dopamine in AD, even in those patients with no evidence of Parkinsonism, behavioral abnormalities or psychosis... - Diffusion tensor imaging in patients with primary cervical dystonia and in patients with blepharospasmG Fabbrini
Department of Neurological Sciences and Neuromed Institute IRCCS, La Sapienza University of Rome, Rome, Italy
Eur J Neurol 15:185-9. 2008..The abnormal DTI findings in patients with CD suggest the presence of brain ultrastructural changes in adult-onset primary CD... - Dopamine influences primary motor cortex plasticity and dorsal premotor-to-motor connectivity in Parkinson's diseaseA Suppa
Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
Cereb Cortex 20:2224-33. 2010..PMd-rTMS reduced the attention-induced MEP facilitation. We conclude that in addition to abnormal M1 plasticity, the reduced MEP facilitation in PD also reflects altered PMd-to-M1 connectivity... - Dopamine and migraine: does Parkinson's disease modify migraine course?P Barbanti
Department of Neurosciences, University La Sapienza, Rome, Italy
Cephalalgia 20:720-3. 2000..Possible explanations include a prolonged prophylactic effect by chronic dopaminergic therapy or a positive effect of PD pathophysiology, namely nigral degeneration, on migraine mechanisms... - Electrical activation of the orbicularis oculi muscle does not increase the effectiveness of botulinum toxin type A in patients with blepharospasmA Conte
Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
Eur J Neurol 17:449-55. 2010..The second aim was to assess the safety of BonT-A by investigating whether BonT-A injection alters the excitability of blink reflex circuits in the brainstem... - The tau gene in progressive supranuclear palsy: exclusion of mutations in coding exons and exon 10 splice sites, and identification of a new intronic variant of the disease-associated H1 haplotype in Italian casesV Bonifati
Department of Neurosciences, La Sapienza University, Roma, Italy
Neurosci Lett 274:61-5. 1999..Although a pathogenic role cannot be entirely excluded, +39deltaG is likely to be a rare polymorphism that may be in linkage disequilibrium with a biologically relevant locus inside or near to the tau gene... - Craniocervical dystonia: clinical and pathophysiological featuresC Colosimo
Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
Eur J Neurol 17:15-21. 2010..The best treatment for craniocervical dystonia is botulinum toxin injected into the overactive muscles... - Somatosensory temporal discrimination in patients with primary focal dystoniaA Scontrini
Department of Neurological Sciences, Sapienza, University of Rome, Rome, Italy
J Neurol Neurosurg Psychiatry 80:1315-9. 2009..To determine whether somatosensory temporal discrimination will reliably detect subclinical sensory impairment in patients with various forms of primary focal dystonia... - Botulinum toxin A modulates afferent fibers in neurogenic detrusor overactivityA Conte
Department of Neurology and Psychiatry, University of Rome, Rome, Italy
Eur J Neurol 19:725-32. 2012..In this study, we investigated whether BoNT/A improves detrusor overactivity by modulating bladder afferent activity... - Pathophysiology of pain and fatigue in Parkinson's diseaseA Berardelli
Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy
Parkinsonism Relat Disord 18:S226-8. 2012.... - Autonomic cardiovascular function and baroreflex sensitivity in patients with cervical dystonia receiving treatment with botulinum toxin type AD Tiple
Department of Neurological Sciences and Neuromed Institute IRCCS, University of Rome La Sapienza, Viale dell Universita, 30, 00185 Roma, Italy
J Neurol 255:843-7. 2008..To investigate possible changes in autonomic cardiovascular regulation and cardiopulmonary baroreflex sensitivity in patients with primary cervical dystonia receiving chronic treatment with botulinum toxin type A... - Camptocormia in Parkinson disease: an epidemiological and clinical studyD Tiple
Department of Neurological Sciences, Sapienza University of Rome, Italy
J Neurol Neurosurg Psychiatry 80:145-8. 2009..Camptocormia is an abnormal flexion of the thoracolumbar spine during standing and walking that abates in the recumbent position... - Excessive daytime somnolence in Parkinson's disease. Follow-up after 1 year of treatmentG Fabbrini
Department of Neurological Sciences, University La Sapienza, , Rome, Italy
Neurol Sci 24:178-9. 2003.... - A transverse and longitudinal MR imaging voxel-based morphometry study in patients with primary cervical dystoniaP Pantano
Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
AJNR Am J Neuroradiol 32:81-4. 2011..Our purpose was to evaluate GM volumes in patients with CD at baseline and 5 years later... - Onset and spread of dyskinesias and motor symptoms in Parkinson's diseaseGiovanni Fabbrini
Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy
Mov Disord 24:2091-6. 2009..In this group, clinical examination yielded a significantly different distribution of LID and motor symptoms. These findings suggest that the onset and spread of LID and motor symptoms may follow different anatomical patterns... - Migraine patients show an increased density of dopamine D3 and D4 receptors on lymphocytesP Barbanti
Department of Neuroscience, University La Sapienza, Rome, Italy
Cephalalgia 20:15-9. 2000..These findings support the view that dopamine D2-like receptors are involved in the determination of the so-called migraine trait, which may help to elucidate several clinical features of the disease... - A large Italian family with Gilles de la Tourette syndrome: clinical study and analysis of the SLITRK1 geneGiovanni Fabbrini
Department of Neurological Sciences and Neuromed Institute, University La Sapienza, Rome, Italy
Mov Disord 22:2229-34. 2007..The negative results of the SLITRK1 analysis point to genetic heterogeneity in TS... - Observational study of sleep-related disorders in Italian patients with Parkinson's disease: usefulness of the Italian version of Parkinson's disease sleep scaleM T Pellecchia
Department of Neurological Sciences, University of Naples, Federico II, Naples, Italy
Neurol Sci 33:689-94. 2012..Daytime sleepiness, depressive symptoms and disease severity correlate with sleep disturbances in Italian PD patients. The PDSS is a valid and reliable tool to evaluate sleep disturbances in Italian patients... - Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO studyCarlo Colosimo
Dipartimento di Scienze Neurologiche, Sapienza Universita di Roma, Rome, Italy
J Neurol 257:5-14. 2010..Atypical parkinsonism patients also reported a low QoL, with no significant differences among the different forms, whereas PD and VP patients had a better QoL... - No clinical or neurophysiological evidence of botulinum toxin diffusion to non-injected muscles in patients with hemifacial spasmC Lorenzano
Department of Neurosciences and Institute Neuromed (IRCCS, University of Rome La Sapienza, Roma, Italy
Neurotox Res 9:141-4. 2006.... - Epidemiology of multiple system atrophy. ESGAP Consortium. European Study Group on Atypical ParkinsonismsN Vanacore
Department of Neurological Sciences, La Sapienza University, Rome, Italy
Neurol Sci 22:97-9. 2001..We have performed a case-control study on 73 MSA cases, 146 hospital controls and 73 population controls... - Migraine and the extrapyramidal systemP Barbanti
Department of Neurological Sciences, University La Sapienza, Rome, Italy
Cephalalgia 22:2-11. 2002..On the other hand, the involvement of EPS in migraine may reflect its more general role in the processing of nociceptive information and/or may be part of the complex behavioural adaptive response that characterizes migraine... - Unilateral cranial autonomic symptoms in migraineP Barbanti
Department of Neurological Sciences, University La Sapienza, Rome, Italy
Cephalalgia 22:256-9. 2002..These findings could have therapeutic implications, given the potential large-scale recruitment of peripheral neurovascular 5-HT(1B/1D) receptors (the target of acute migraine treatment) in such patients... - Pathophysiology of tics and Tourette syndromeAlfredo Berardelli
Dept of Neurological Sciences and Istituto Neurologico Mediterraneo, Neuromed IRCCS, Pozzilli IS University of Rome La Sapienza, Rome, Italy
J Neurol 250:781-7. 2003..Dysfunction of basal ganglia-thalamo-cortical projections affects sensorimotor, language and limbic cortical circuits, and may explain why patients with Tourette syndrome have difficulty in inhibiting unwanted behaviors and impulses... - Drug Insight: new drugs in development for Parkinson's diseaseCarlo Colosimo
University Department of Neurosciences University of Rome, La Sapienza, Italy
Nat Clin Pract Neurol 2:600-10. 2006..In this Review, we discuss the numerous drugs in development that target the primary motor disorder in Parkinson's disease... - Task force report on scales to assess dyskinesia in Parkinson's disease: critique and recommendationsCarlo Colosimo
Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy
Mov Disord 25:1131-42. 2010..As further testing of these scales in PD is warranted, no new scales are needed until the available scales are fully tested clinimetrically... - Psychopathological features of obsessive-compulsive disorder in an Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 geneMassimo Pasquini
Department of Psychiatric Science and Psychological Medicine, Sapienza University of Rome, Rome, Italy
Psychiatry Res 161:109-11. 2008..Ten patients were found to have obsessive-compulsive disorder in which tic-like compulsions predominated. The distinctive feature of this family is the high frequency of obsessive-compulsive disorder with various clinical phenotypes... - Fatigue in Parkinson's disease: motor or non-motor symptom?G Fabbrini
Department of Neurology and Psychiatry, Sapienza University of Rome, Viale dell Universita 30, 00185 Rome, Italy
Parkinsonism Relat Disord 19:148-52. 2013..Neuroimaging studies show that fatigue is associated with an involvement of non-dopaminergic or extrastriatal dopaminergic pathways. It is conceivable that both motor and non-motor mechanisms underlie the pathophysiology of fatigue... - Somatosensory temporal discrimination threshold may help to differentiate patients with multiple system atrophy from patients with Parkinson's diseaseL Rocchi
Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy
Eur J Neurol 20:714-9. 2013..Possible differences between the two groups may help to differentiate MSA-P from PD... 
Cutaneous innervation and trigeminal pathway function in a patient with facial pain associated with Parry-Romberg syndromeM Falla
Department of Neurology and Psychiatry, Sapienza University, Viale Università 30, 00185, Rome, Italy
J Headache Pain 13:497-9. 2012..These findings indicate that in this patient PRS-related pain is not a neuropathic pain condition, rather it probably arises from the musculoskeletal abnormalities...- Bradykinesia in patients with obsessive-compulsive disorderM Pasquini
Department of Psychiatric Sciences and Psychological Medicine, Sapienza University of Rome, Rome, Italy
Eur Psychiatry 25:378-81. 2010..To investigate the frequency of bradykinesia in patients with obsessive-compulsive disorder (OCD) and to see whether patients with OCD who also have bradykinesia display distinctive neuropsychological and neuropsychiatric features... - Donepezil in the treatment of hallucinations and delusions in Parkinson's diseaseG Fabbrini
Department of Neurological Sciences, La Sapienza University, , I-00185 Rome, Italy
Neurol Sci 23:41-3. 2002..Hallucinations and delusions improved significantly in all patients. Donezepil was overall well tolerated, but a deterioration in motor disability was noted in 2 out of 8 patients... - Headache in cranial and cervical dystoniaP Barbanti
Department of Neurosciences, University La Sapienza, Rome, Italy
Neurology 64:1308-9. 2005 - Hedonistic homeostatic dysregulation in Parkinson's disease: a short screening questionnaireF R Pezzella
Dipartimento di Scienze Neurologiche, , Rome, Italy
Neurol Sci 24:205-6. 2003 - Mitochondrial myopathy, parkinsonism, and multiple mtDNA deletions in a Sephardic Jewish familyC Casali
Neurological Institute, La Sapienza University, Rome, Italy
Neurology 56:802-5. 2001.... - Diffusion tensor imaging in primary cervical dystoniaC Colosimo
Department of Neurological Sciences, University La Sapienza, I 00185 Rome, Italy
J Neurol Neurosurg Psychiatry 76:1591-3. 2005..It is the traditional view that primary dystonia arises from abnormal basal ganglia function but causes no apparent morphological changes... - Amitriptyline is effective in chronic but not in episodic tension-type headache: pathogenetic implicationsR Cerbo
Department of Neurosciences, University La Sapienza, Rome, Italy
Headache 38:453-7. 1998.... - Impact of the International Headache Society criteria on the use of neuroimaging for headache diagnosis in a headache clinicG Fabbrini
Department of Neurological Sciences, University La Sapienza, , 30, 00185 Rome, Italy
Headache 39:747-51. 1999..An improved definition of secondary forms of headache might help to reduce this adjunctive cost to the care of patients with headache in a headache clinic... - Altered response to rTMS in patients with Alzheimer's diseaseM Inghilleri
Department of Neurological Sciences, University of Rome La Sapienza, Viale dell Universita, 30, 00185 Rome, Italy
Clin Neurophysiol 117:103-9. 2006.... - Acute pathological laughter induced by sumatriptanP Barbanti
Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele, Rome, Italy
Cephalalgia 28:92-3. 2008 - Psychiatric disorders in adult-onset focal dystonia: a case-control studyGiovanni Fabbrini
Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy
Mov Disord 25:459-65. 2010..The most common psychiatric features in patients with CD and BPS are depressive disorders... - Excessive daytime sleepiness in de novo and treated Parkinson's diseaseGiovanni Fabbrini
Department of Neurological Sciences, University La Sapienza, Rome, Italy
Mov Disord 17:1026-30. 2002..Differences in ESS score variability were best explained by the treatment effect, whereas there was no clear correlation between PSQI and any of the clinical variables considered... - Voluntary, spontaneous, and reflex blinking in Parkinson's diseaseRocco Agostino
Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
Mov Disord 23:669-75. 2008..PD patients also display kinematic abnormalities of spontaneous blinking and changes in the excitability of the closing phase of reflex blinking... - Mirror movements in patients with Parkinson's diseaseDonatella Ottaviani
Department of Neurological Sciences and Neuromed Institute IRCCS, La Sapienza University of Rome, Rome, Italy
Mov Disord 23:253-8. 2008..16, P < 0.01). The low frequency of MM in PD probably relates to the complex interactions between the pathophysiological mechanisms leading to parkinsonian signs and the mechanisms responsible for movement lateralization... - A novel family with an unusual early-onset generalized dystoniaGiovanni Fabbrini
Department of Neurological Sciences, University La Sapienza, Rome, Italy
Mov Disord 20:81-6. 2005..The condition we describe could be a newly recognized dystonia syndrome with parkinsonism... - Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinson's diseaseAntonella Conte
Department of Neurological Sciences, Sapienza University of Rome, Viale dell Universita 30, Rome, Italy
Brain 133:2656-63. 2010..Deep brain stimulation degrades somatosensory temporal discrimination by modifying central somatosensory processing whereas dopamine restores the interplay between cortical and subcortical structures... - Prevalence and clinical features of hedonistic homeostatic dysregulation in Parkinson's diseaseFrancesca Romana Pezzella
Department of Neurological Sciences, La Sapienza University, Rome, Italy
Mov Disord 20:77-81. 2005..Of interest, our patients showed a somewhat different pattern of the disorder, suggesting that cultural and environmental factors may play a role in the phenomenology of HHD... - Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7V Bonifati
Department of Neurological Sciences, La Sapienza University, Viale dell Universita 30, I 00185 Rome, Italy
Neurol Sci 23:S59-60. 2002..This will contribute to unraveling the pathogenesis of AREP, and it is also expected to foster our understanding of molecular events underlying classic Parkinson's disease... - A comparative study of primary and secondary hemifacial spasmCarlo Colosimo
Department of Neurosciences and Neuromed Institute, University of Rome La Sapienza, Rome, Italy
Arch Neurol 63:441-4. 2006..Signs of synkinesis were present in significant proportions of patients with primary or secondary HFS. The 2 forms differed in clinical presentation... - Migraine and Tourette syndromePiero Barbanti
Arch Neurol 61:606-7; author reply 607. 2004 - Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's diseaseAlessio Di Fonzo
Department of Clinical Genetics, Erasmus MC Rotterdam, Rotterdam, The Netherlands
Eur J Hum Genet 14:322-31. 2006..These data have implications both for understanding the molecular mechanisms of PD, and for directing the genetic screening in clinical practice... - Pain as a nonmotor symptom of Parkinson disease: evidence from a case-control studyGiovanni Defazio
Department of Neurology and Psychiatry, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
Arch Neurol 65:1191-4. 2008..To determine whether pain is more frequent among people with Parkinson disease (PD) than among age-matched controls... - Novel parkin mutations detected in patients with early-onset Parkinson's diseaseAida M Bertoli-Avella
Genetic Epidemiologic Unit, Department of Clinical Genetics and Department of Epidemiology and Biostatistics, Erasmus MC Rotterdam, The Netherlands
Mov Disord 20:424-31. 2005..This study confirms the frequent involvement of parkin and the importance of genetic testing in the diagnostic work-up of EOP...