Francesco Epifano

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. doi request reprint Phytochemistry and pharmacognosy of the genus Acronychia
    Francesco Epifano
    Dipartimento di Farmacia, Università G D Annunzio Chieti Pescara, Via dei Vestini 31, 66013 Chieti Scalo CH, Italy Electronic address
    Phytochemistry 95:12-8. 2013
  2. pmc The plant coumarins auraptene and lacinartin as potential multifunctional therapeutic agents for treating periodontal disease
    Annie Marquis
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, 2420 Rue de la Terrasse, Quebec City, QC, Canada
    BMC Complement Altern Med 12:80. 2012
  3. ncbi request reprint Phytochemistry and pharmacognosy of naturally occurring prenyloxyanthraquinones
    Francesco Epifano
    Dipartimento di Farmacia, Università degli Studi G d Annunzio Chieti Pescara, Via dei Vestini 31, 66100, Italy
    Curr Drug Targets 14:959-63. 2013
  4. ncbi request reprint Re-investigation of the anthraquinone pool of Rhamnus spp.: madagascin from the fruits of Rhamnus cathartica and R. intermedia
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Università G D Annunzio Chieti Pescara, Via dei Vestini 31, 66100 Chieti Scalo CH, Italy
    Nat Prod Commun 7:1029-32. 2012
  5. doi request reprint Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Università G D Annunzio Chieti Pescara, Via dei Vestini 31, 66100 Chieti Scalo CH, Italy
    Bioorg Med Chem Lett 22:3130-5. 2012
  6. ncbi request reprint Insights on novel biologically active natural products: 7-isopentenyloxycoumarin
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Via dei Vestini 31, Chieti Scalo, Italy, 66013
    Nat Prod Commun 4:1755-60. 2009
  7. ncbi request reprint Searching for novel cancer chemopreventive plants and their products: the genus Zanthoxylum
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Chieti Scalo, Italy
    Curr Drug Targets 12:1895-902. 2011
  8. ncbi request reprint Chemistry and pharmacology of collinin, active principle of Zanthoxylum spp
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti Scalo CH, Italy
    Mini Rev Med Chem 8:1203-8. 2008
  9. doi request reprint Neuroprotective effect of prenyloxycoumarins from edible vegetables
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66013 Chieti Scalo, Italy
    Neurosci Lett 443:57-60. 2008
  10. ncbi request reprint Chemistry and pharmacology of oxyprenylated secondary plant metabolites
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Chieti Scalo, Italy
    Phytochemistry 68:939-53. 2007

Collaborators

Detail Information

Publications42

  1. doi request reprint Phytochemistry and pharmacognosy of the genus Acronychia
    Francesco Epifano
    Dipartimento di Farmacia, Università G D Annunzio Chieti Pescara, Via dei Vestini 31, 66013 Chieti Scalo CH, Italy Electronic address
    Phytochemistry 95:12-8. 2013
    ....
  2. pmc The plant coumarins auraptene and lacinartin as potential multifunctional therapeutic agents for treating periodontal disease
    Annie Marquis
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, 2420 Rue de la Terrasse, Quebec City, QC, Canada
    BMC Complement Altern Med 12:80. 2012
    ..We also investigated the capacity of these compounds to reduce cytokine and matrix metalloproteinase (MMP) secretion by lipopolysaccharide (LPS)-stimulated macrophages and to inhibit MMP-9 activity...
  3. ncbi request reprint Phytochemistry and pharmacognosy of naturally occurring prenyloxyanthraquinones
    Francesco Epifano
    Dipartimento di Farmacia, Università degli Studi G d Annunzio Chieti Pescara, Via dei Vestini 31, 66100, Italy
    Curr Drug Targets 14:959-63. 2013
    ..In this review article we will focus on the phytochemistry and pharmacognosy of prenyloxyanthraquinones putting in evidence the natural sources and their biological properties as anti-microbial and anticancer agents. ..
  4. ncbi request reprint Re-investigation of the anthraquinone pool of Rhamnus spp.: madagascin from the fruits of Rhamnus cathartica and R. intermedia
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Università G D Annunzio Chieti Pescara, Via dei Vestini 31, 66100 Chieti Scalo CH, Italy
    Nat Prod Commun 7:1029-32. 2012
    ..cathartica L. and R. intermedia Steud. and Hochst. The title compound is described herein for the first time as a component of fruit extracts of Rhamnus species...
  5. doi request reprint Nelumal A, the active principle from Ligularia nelumbifolia, is a novel farnesoid X receptor agonist
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Università G D Annunzio Chieti Pescara, Via dei Vestini 31, 66100 Chieti Scalo CH, Italy
    Bioorg Med Chem Lett 22:3130-5. 2012
    ..Nelumal A is thus of interest as a valuable potential novel lead compound in the search for FXR agonists...
  6. ncbi request reprint Insights on novel biologically active natural products: 7-isopentenyloxycoumarin
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Via dei Vestini 31, Chieti Scalo, Italy, 66013
    Nat Prod Commun 4:1755-60. 2009
    ..The aim of this review is to examine the phytochemical and pharmacological properties of this compound...
  7. ncbi request reprint Searching for novel cancer chemopreventive plants and their products: the genus Zanthoxylum
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Chieti Scalo, Italy
    Curr Drug Targets 12:1895-902. 2011
    ....
  8. ncbi request reprint Chemistry and pharmacology of collinin, active principle of Zanthoxylum spp
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti Scalo CH, Italy
    Mini Rev Med Chem 8:1203-8. 2008
    ..The aim of this review is to examine the phytochemical and pharmacological properties of this compound...
  9. doi request reprint Neuroprotective effect of prenyloxycoumarins from edible vegetables
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66013 Chieti Scalo, Italy
    Neurosci Lett 443:57-60. 2008
    ....
  10. ncbi request reprint Chemistry and pharmacology of oxyprenylated secondary plant metabolites
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Chieti Scalo, Italy
    Phytochemistry 68:939-53. 2007
    ..The aim of this review is to examine in detail the different types of oxyprenylated natural compounds from a phytochemical and pharmacological point of view...
  11. ncbi request reprint Natural coumarins as a novel class of neuroprotective agents
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Chieti Scalo, Italy
    Mini Rev Med Chem 9:1262-71. 2009
    ..The aim of this manuscript is to review what has been reported so far in the literature about coumarins as a novel class of pharmacologically active compounds in chemoprevention and/or therapy of these diseases...
  12. ncbi request reprint Synthesis and anti-inflammatory activity of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its ester derivatives
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Via dei Vestini 31, Universita G D Annunzio, Chieti Pescara 66013 Chieti Scalo CH, Italy
    Bioorg Med Chem Lett 17:5709-14. 2007
    ..The activity of the paracetamol, guaiacol and hydroquinone esters of (1) was higher than that of the parent compound, being similar to that exerted by indomethacin, used as reference drug...
  13. ncbi request reprint Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Via dei Vestini 31, 66013 Chieti Scalo CH, Italy
    Bioorg Med Chem Lett 17:2639-42. 2007
    ..No compound was an effective inhibitor of FTase, while farnesyloxycinnamic acids were shown to selectively inhibit GGTase I with IC(50) values ranging from 28 to 39 microM...
  14. doi request reprint Topical anti-inflammatory activity of boropinic acid and its natural and semi-synthetic derivatives
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Università G D Annunzio Chieti Pescara, Via dei Vestini 31, Chieti Scalo CH 66013, Italy
    Bioorg Med Chem Lett 21:769-72. 2011
    ..Some of the tested compounds (15, 17, 19, 20) revealed an effect comparable (ID(50)=0.18÷0.72μmol/cm(2)) to that of the reference drug indomethacin (ID(50)=0.23μmol/cm(2)), a non-steroidal anti-inflammatory drug...
  15. ncbi request reprint In vitro inhibitory activity of boropinic acid against Helicobacter pylori
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Via dei Vestini 31, 66013 Chieti Scalo CH, Italy
    Bioorg Med Chem Lett 16:5523-5. 2006
    ..Boropinic acid, active principle isolated from Boronia pinnata (Fam. Rutaceae), was seen to be the most effective compound with a MIC value of 1.62 microg/mL...
  16. doi request reprint Inhibition of COX-1 activity and COX-2 expression by 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its semi-synthetic derivatives
    Salvatore Genovese
    Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Via dei Vestini 31, 66100 Chieti Scalo CH, Italy
    Bioorg Med Chem Lett 21:5995-8. 2011
    ..Moreover compounds (1) and (4) inhibit dose-dependently LPS-induced COX-2 expression...
  17. doi request reprint Chemical composition and inhibitory activity against Helicobacter pylori of the essential oil of Apium nodiflorum (Apiaceae)
    Luigi Menghini
    Dipartimento di Scienze del Farmaco, Università G D Annunzio Chieti Pescara, Chieti Scalo, Italy
    J Med Food 13:228-30. 2010
    ..62%) were the main components. The antimicrobial activity of the essential oil was assayed in vitro against Helicobacter pylori (strain DSMZ 4867), resulting in a minimum inhibitory concentration value of 12.5 microg/mL...
  18. doi request reprint Development and application of high-performance liquid chromatography for the study of two new oxyprenylated anthraquinones produced by Rhamnus species
    Marcello Locatelli
    Dipartimento di Scienze del Farmaco, Università degli Studi G d Annunzio Chieti Pescara, Via dei Vestini 31, 66100 Chieti CH, Italy
    J Chromatogr A 1225:113-20. 2012
    ..barks as well as the anthraquinone profile of Rhamnus pumila Turra. The proposed method could be directly applied to the selective quantification of these analytes in natural sources...
  19. doi request reprint Chemistry and biological activity of azoprenylated secondary metabolites
    Salvatore Genovese
    Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Via dei Vestini 31, 66100 Chieti Scalo CH, Italy
    Phytochemistry 70:1082-91. 2009
    ..The aim of this comprehensive review is to examine the different types of prenylazo natural products from a chemical, phytochemical and biological perspective...
  20. doi request reprint Antiinflammatory activity of coumarins from Ligusticum lucidum Mill. subsp. cuneifolium (Guss.) Tammaro (Apiaceae)
    Luigi Menghini
    Dipartimento di Scienze del Farmaco, University G d Annunzio of Chieti Pescara, Via dei Vestini 31, 66013 Chieti Scalo, Italy
    Phytother Res 24:1697-9. 2010
    ..Each compound (0.3 μmol/cm(2) ) induced a significant oedema reduction and compound 4 exerted an effect similar to that of the equimolar dose of the reference drug indomethacin...
  21. doi request reprint Conjugation of l-NAME to prenyloxycinnamic acids improves its inhibitory effects on nitric oxide production
    Salvatore Genovese
    Dipartimento di Farmacia, Università G D Annunzio Chieti Pescara, Via dei Vestini 31, 66100 Chieti Scalo CH, Italy
    Bioorg Med Chem Lett 23:2933-5. 2013
    ..7 macrophages. Results indicated that the coupling between O-geranyl and O-isopentenylcinnamic acids and l-NAME led to products with an enhanced activity when compared to the parent compounds...
  22. ncbi request reprint Anthraquinone profile, antioxidant and antimicrobial properties of bark extracts of Rhamnus catharticus and R. orbiculatus
    Marcello Locatelli
    Dipartimento di Scienze del Farmaco, Università degli Studi G d Annunzio di Chieti Pescara, Via dei Vestini 31, 66100 Chieti, Italy
    Nat Prod Commun 6:1275-80. 2011
    ..R. catharticus and R. orbiculatus contained several anthranoid aglycones and their bark extracts demonstrated notable antioxidant and antimicrobial properties. The results obtained indicate the medicinal potential of these two species...
  23. ncbi request reprint In vitro anti-proliferative effect of naturally occurring oxyprenylated chalcones
    Serena Fiorito
    Dipartimento di Farmacia, Università G D Annunzio Chieti Pescara, Via dei Vestini 31, 66100 Chieti Scalo CH, Italy
    Nat Prod Commun 8:1089-92. 2013
    ....
  24. ncbi request reprint Recent developments in the pharmacological properties of 4'-geranyloxyferulic acid, a colon cancer chemopreventive agent of natural origin
    Salvatore Genovese
    Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Chieti Scalo, CH, Italy
    Curr Drug Targets 13:1083-8. 2012
    ..The aim of this review is to examine in detail the recently reported properties of 4'-geranyloxyferulic acid from a chemical and pharmacological point of view, including the recent acquisition about its mechanism of action...
  25. doi request reprint Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives
    Serena Fiorito
    Dipartimento di Farmacia, Università G D Annunzio Chieti Pescara, Via dei Vestini 31, 66100 Chieti Scalo CH, Italy
    Bioorg Med Chem Lett 24:454-7. 2014
    ..The data revealed that of the chemicals under study only lapachol, its acetate and 3-geranyllawsone displayed the highest activity, recording mean IC50 values ranging from 15 to 22μM. ..
  26. pmc Auraptene and its effects on the re-emergence of colon cancer stem cells
    Francesco Epifano
    Dipartimento di Scienze del Farmaco, Università G D Annunzio Chieti Pescara, Via dei Vestini 31, 66100, Chieti, Italy
    Phytother Res 27:784-6. 2013
    ..These findings suggest that AUR could prevent the re-emergence of CSCs...
  27. doi request reprint Rhamnus alpinus leaf extract suppresses lipopolysaccharide-induced, monocyte-derived macrophage chemokine secretion
    Annalisa Chiavaroli
    Dipartimento di Science del Farmaco, Via dei Vestini 31, 66013 Chieti Scalo, Chieti, Italy
    Inflammation 31:313-8. 2008
    ..This may impede the progression and aggravation of inflammation given that the migration of immune cells plays an important role in the outcome of periodontitis...
  28. ncbi request reprint Novel prodrugs for the treatment of colonic diseases based on 5-aminosalicylic acid, 4'-geranyloxyferulic acid, and auraptene: biological activities and analytical assays
    Francesco Epifano
    Universita degli Studi G D Annunzio, Chieti Pescara, Facolta di Farmacia, Dipartimento di Scienze del Farmaco, Via dei Vestini 31, 66100 Chieti CH, Italy
    Curr Drug Deliv 9:112-21. 2012
    ....
  29. doi request reprint Recent application of analytical methods to phase I and phase II drugs development: a review
    Marcello Locatelli
    Dipartimento di Scienze del Farmaco, Università degli Studi G d Annunzio Chieti Pescara, Via dei Vestini 31, 66100, Chieti, Italy
    Biomed Chromatogr 26:283-300. 2012
    ..The aim of this review is to report the processes required for the validation of drug efficacy with reference to the description of 'classic' and modern techniques used...
  30. pmc A natural propenoic acid derivative activates peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta)
    Salvatore Genovese
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti Pescara, Via dei Vestini 31, 66100 Chieti Scalo, Italy
    Life Sci 86:493-8. 2010
    ..Given the structural similarities between these compounds and known peroxisome proliferator-activated receptor (PPAR) agonists, the present study examined the hypothesis that propenoic acid derivatives activate PPARs...
  31. doi request reprint Phytochemical investigation on leaf extract of Cordia salicifolia Cham
    Luigi Menghini
    Dipartimento di Scienze del Farmaco, University G D Annunzio, Chieti Scalo, Italy
    J Med Food 11:193-4. 2008
    ..53%). The major component of the extract exhibited a very weak activity as an inhibitor of growth of Helicobacter pylori in vitro (minimum inhibitory concentration = 200 microg/mL)...
  32. doi request reprint Prenyloxyphenylpropanoids as a novel class of anticonvulsive agents
    Salvatore Genovese
    Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Via dei Vestini 31, 66013 Chieti Scalo CH, Italy
    Bioorg Med Chem Lett 19:5419-22. 2009
    ..7-Isopentenyloxycoumarin and (2E)-3-{4-[(3-methylbut-2-enyl)oxy]phenyl}prop-2-enoic acid, administered ip at a dose of 300 mg/kg, suppressed MES-induced seizures in mice in a time- and dose-dependent manner...
  33. ncbi request reprint Auraptene: a natural biologically active compound with multiple targets
    Salvatore Genovese
    Dipartimento di Scienze del Farmaco, Università G d Annunzio di Chieti Pescara, Via dei Vestini 31, Chieti Scalo CH, Italy
    Curr Drug Targets 12:381-6. 2011
    ....
  34. ncbi request reprint Anti-inflammatory sesquiterpene lactones from Lourteigia ballotaefolia
    Alfredo Rosas-Romero
    Departamento de Quimica, Universidad Simon Bolivar, Caracas, Venezuela
    Planta Med 68:843-5. 2002
    ..The minor component, 9beta-(tigloyloxy)-atripliciolide, is a new compound. The anti-inflammatory activity of compounds 1 and 2 was evaluated using the croton oil ear test in mice...
  35. ncbi request reprint Fatty acids profile and antiinflammatory activity of Nonea setosa R. et S
    Massimo Curini
    Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Perugia, Italy
    Phytother Res 20:422-3. 2006
    ..GC-MS analysis of the most active fraction revealed the presence of high amounts of polyunsaturated fatty acids...
  36. ncbi request reprint Effects of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its ester derivatives on biofilm formation by two oral pathogens, Porphyromonas gingivalis and Streptococcus mutans
    Charles Bodet
    Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire, Universite Laval, Quebec City, Quebec G1K 7P4, Canada
    Eur J Med Chem 43:1612-20. 2008
    ..mutans, a phenomenon not related to growth inhibition. These data suggest that 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and some of its ester derivatives may have a therapeutic/preventive potential for oral infections...
  37. ncbi request reprint Chemistry and biological activity of natural and synthetic prenyloxycoumarins
    Massimo Curini
    Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Via del Liceo, 06123 Perugia, Italy
    Curr Med Chem 13:199-222. 2006
    ..The object of this review is to examine in detail the different types of prenyloxycoumarins and prenyloxyfuranocoumarins from the chemical, phytochemical and biological point of view...
  38. ncbi request reprint Synthesis of a novel prodrug of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans-propenoic acid for colon delivery
    Massimo Curini
    Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Via del Liceo, 06123 Perugia, Italy
    Bioorg Med Chem Lett 15:5049-52. 2005
    ..Data on the chemical and enzymatic stability of this novel prodrug are reported...
  39. ncbi request reprint 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid: a novel promising cancer chemopreventive agent
    Massimo Curini
    Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Via del Liceo, Perugia, Italy
    Anticancer Agents Med Chem 6:571-7. 2006
    ..The aim of this review is to examine in detail the properties of the title compound so far reported in the literature from a chemical and pharmacological point of view...
  40. ncbi request reprint Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 118:2936-42. 2006
    ..Our findings may suggest that certain prenyloxycoumarins, such as auraptene and collinin, could serve as an effective agent against colitis-related colon cancer development in rodents...
  41. ncbi request reprint Chemical composition, antimicrobial and antioxidant activity of the essential oil of Teucrium marum (Lamiaceae)
    Donata Ricci
    Istituto di Botanica e Orto Botanico Pierina Scaramella, Facolta di Farmacia, Universita degli Studi di Urbino Carlo Bo, Urbino, PU, Italy
    J Ethnopharmacol 98:195-200. 2005
    ..The antioxidant activity of the essential oil was evaluated using the DPPH test, 5-lipoxygenase test and luminol/xanthine/xanthine oxidase chemiluminescence assay...
  42. ncbi request reprint Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins
    Massimo Curini
    Dipartimento di Chimica e Tecnologia del Farmaco, Sezione di Chimica Organica, Universita degli Studi, Via del Liceo, 06123 Perugia, Italy
    Bioorg Med Chem Lett 14:2241-3. 2004
    ..25 micromol/cm(2) of the reference drug indomethacin, a nonsteroidal anti-inflammatory drug...