Francesco Epifano

..cathartica L. and R. intermedia Steud. and Hochst. The title compound is described herein for the first time as a component of fruit extracts of Rhamnus species...

..Nelumal A is thus of interest as a valuable potential novel lead compound in the search for FXR agonists...

..The aim of this review is to examine the phytochemical and pharmacological properties of this compound...

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..Some of the tested compounds (15, 17, 19, 20) revealed an effect comparable (ID(50)=0.18÷0.72μmol/cm(2)) to that of the reference drug indomethacin (ID(50)=0.23μmol/cm(2)), a non-steroidal anti-inflammatory drug...

..The activity of the paracetamol, guaiacol and hydroquinone esters of (1) was higher than that of the parent compound, being similar to that exerted by indomethacin, used as reference drug...

..The aim of this review is to examine in detail the different types of oxyprenylated natural compounds from a phytochemical and pharmacological point of view...

..No compound was an effective inhibitor of FTase, while farnesyloxycinnamic acids were shown to selectively inhibit GGTase I with IC(50) values ranging from 28 to 39 microM...

..The aim of this manuscript is to review what has been reported so far in the literature about coumarins as a novel class of pharmacologically active compounds in chemoprevention and/or therapy of these diseases...

..Boropinic acid, active principle isolated from Boronia pinnata (Fam. Rutaceae), was seen to be the most effective compound with a MIC value of 1.62 microg/mL...

..The aim of this review is to examine the phytochemical and pharmacological properties of this compound...

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..Moreover compounds (1) and (4) inhibit dose-dependently LPS-induced COX-2 expression...

..62%) were the main components. The antimicrobial activity of the essential oil was assayed in vitro against Helicobacter pylori (strain DSMZ 4867), resulting in a minimum inhibitory concentration value of 12.5 microg/mL...

..barks as well as the anthraquinone profile of Rhamnus pumila Turra. The proposed method could be directly applied to the selective quantification of these analytes in natural sources...

..The aim of this comprehensive review is to examine the different types of prenylazo natural products from a chemical, phytochemical and biological perspective...

..Each compound (0.3 μmol/cm(2) ) induced a significant oedema reduction and compound 4 exerted an effect similar to that of the equimolar dose of the reference drug indomethacin...

..R. catharticus and R. orbiculatus contained several anthranoid aglycones and their bark extracts demonstrated notable antioxidant and antimicrobial properties. The results obtained indicate the medicinal potential of these two species...

..The aim of this review is to examine in detail the recently reported properties of 4'-geranyloxyferulic acid from a chemical and pharmacological point of view, including the recent acquisition about its mechanism of action...

..This may impede the progression and aggravation of inflammation given that the migration of immune cells plays an important role in the outcome of periodontitis...

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..The aim of this review is to report the processes required for the validation of drug efficacy with reference to the description of 'classic' and modern techniques used...

..53%). The major component of the extract exhibited a very weak activity as an inhibitor of growth of Helicobacter pylori in vitro (minimum inhibitory concentration = 200 microg/mL)...

..Given the structural similarities between these compounds and known peroxisome proliferator-activated receptor (PPAR) agonists, the present study examined the hypothesis that propenoic acid derivatives activate PPARs...

..7 macrophages. Results indicated that the coupling between O-geranyl and O-isopentenylcinnamic acids and l-NAME led to products with an enhanced activity when compared to the parent compounds...

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..7-Isopentenyloxycoumarin and (2E)-3-{4-[(3-methylbut-2-enyl)oxy]phenyl}prop-2-enoic acid, administered ip at a dose of 300 mg/kg, suppressed MES-induced seizures in mice in a time- and dose-dependent manner...

..These findings suggest that AUR could prevent the re-emergence of CSCs. Copyright © 2012 John Wiley & Sons, Ltd...

..Data on the chemical and enzymatic stability of this novel prodrug are reported...

..The minor component, 9beta-(tigloyloxy)-atripliciolide, is a new compound. The anti-inflammatory activity of compounds 1 and 2 was evaluated using the croton oil ear test in mice...

..The object of this review is to examine in detail the different types of prenyloxycoumarins and prenyloxyfuranocoumarins from the chemical, phytochemical and biological point of view...

..GC-MS analysis of the most active fraction revealed the presence of high amounts of polyunsaturated fatty acids...

..The aim of this review is to examine in detail the properties of the title compound so far reported in the literature from a chemical and pharmacological point of view...

..mutans, a phenomenon not related to growth inhibition. These data suggest that 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and some of its ester derivatives may have a therapeutic/preventive potential for oral infections...

..The antioxidant activity of the essential oil was evaluated using the DPPH test, 5-lipoxygenase test and luminol/xanthine/xanthine oxidase chemiluminescence assay...

..25 micromol/cm(2) of the reference drug indomethacin, a nonsteroidal anti-inflammatory drug...

..Our findings may suggest that certain prenyloxycoumarins, such as auraptene and collinin, could serve as an effective agent against colitis-related colon cancer development in rodents...