R Elisei

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. pmc RET/PTC Translocations and Clinico-Pathological Features in Human Papillary Thyroid Carcinoma
    Cristina Romei
    Department of Endocrinology and Metabolism, WHO Collaborating Center for the Study and Treatment of Thyroid Diseases and Other Endocrine and Metabolic Disorders University of Pisa, Pisa, Italy
    Front Endocrinol (Lausanne) 3:54. 2012
  2. doi request reprint The BRAF(V600E) mutation is an independent, poor prognostic factor for the outcome of patients with low-risk intrathyroid papillary thyroid carcinoma: single-institution results from a large cohort study
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 97:4390-8. 2012
  3. ncbi request reprint Modifications in the papillary thyroid cancer gene profile over the last 15 years
    Cristina Romei
    Department of Endocrinology and Metabolism and World Health Organization Collaborating Center for the Study and Treatment of Thyroid Diseases and Other Endocrine and Metabolic Disorders, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 97:E1758-65. 2012
  4. doi request reprint The timing of total thyroidectomy in RET gene mutation carriers could be personalized and safely planned on the basis of serum calcitonin: 18 years experience at one single center
    Rossella Elisei
    Department of Endocrinology and Metabolism, World Health Organization Collaborating Center for the Diagnosis and Treatment of Thyroid Cancer and Other Thyroid Diseases, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 97:426-35. 2012
  5. ncbi request reprint Identification of a novel point mutation in the RET gene (Ala883Thr), which is associated with medullary thyroid carcinoma phenotype only in homozygous condition
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:5823-7. 2004
  6. doi request reprint Are the clinical and pathological features of differentiated thyroid carcinoma really changed over the last 35 years? Study on 4187 patients from a single Italian institution to answer this question
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 95:1516-27. 2010
  7. doi request reprint Follow-up of low-risk differentiated thyroid cancer patients who underwent radioiodine ablation of postsurgical thyroid remnants after either recombinant human thyrotropin or thyroid hormone withdrawal
    R Elisei
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 94:4171-9. 2009
  8. doi request reprint Routine serum calcitonin measurement in the evaluation of thyroid nodules
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, Pisa, Italy
    Best Pract Res Clin Endocrinol Metab 22:941-53. 2008
  9. ncbi request reprint Low specificity of blood thyroglobulin messenger ribonucleic acid assay prevents its use in the follow-up of differentiated thyroid cancer patients
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:33-9. 2004
  10. ncbi request reprint Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10,864 patients with nodular thyroid disorders
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:163-8. 2004

Detail Information

Publications77

  1. pmc RET/PTC Translocations and Clinico-Pathological Features in Human Papillary Thyroid Carcinoma
    Cristina Romei
    Department of Endocrinology and Metabolism, WHO Collaborating Center for the Study and Treatment of Thyroid Diseases and Other Endocrine and Metabolic Disorders University of Pisa, Pisa, Italy
    Front Endocrinol (Lausanne) 3:54. 2012
    ....
  2. doi request reprint The BRAF(V600E) mutation is an independent, poor prognostic factor for the outcome of patients with low-risk intrathyroid papillary thyroid carcinoma: single-institution results from a large cohort study
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 97:4390-8. 2012
    ..The aim of this study was to evaluate its prognostic significance in a large cohort of low-risk intrathyroid PTC...
  3. ncbi request reprint Modifications in the papillary thyroid cancer gene profile over the last 15 years
    Cristina Romei
    Department of Endocrinology and Metabolism and World Health Organization Collaborating Center for the Study and Treatment of Thyroid Diseases and Other Endocrine and Metabolic Disorders, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 97:E1758-65. 2012
    ....
  4. doi request reprint The timing of total thyroidectomy in RET gene mutation carriers could be personalized and safely planned on the basis of serum calcitonin: 18 years experience at one single center
    Rossella Elisei
    Department of Endocrinology and Metabolism, World Health Organization Collaborating Center for the Diagnosis and Treatment of Thyroid Cancer and Other Thyroid Diseases, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 97:426-35. 2012
    ..In hereditary cases, a germline RET mutation is found in 98% of families. Because MTC is cured only if intrathyroidal, prophylactic thyroidectomy is recommended in the gene carrier (GC)...
  5. ncbi request reprint Identification of a novel point mutation in the RET gene (Ala883Thr), which is associated with medullary thyroid carcinoma phenotype only in homozygous condition
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:5823-7. 2004
    ..The analysis of several RET polymorphisms also confirmed the presence of two mutated alleles in MTC affected patients and both mutated and wild-type allele in heterozygous subjects...
  6. doi request reprint Are the clinical and pathological features of differentiated thyroid carcinoma really changed over the last 35 years? Study on 4187 patients from a single Italian institution to answer this question
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 95:1516-27. 2010
    ..In the last decades, a marked increased prevalence of differentiated thyroid cancer (DTC) has been observed worldwide. The aim of this study was to evaluate the changing features of DTC referred to our institution between 1969 and 2004...
  7. doi request reprint Follow-up of low-risk differentiated thyroid cancer patients who underwent radioiodine ablation of postsurgical thyroid remnants after either recombinant human thyrotropin or thyroid hormone withdrawal
    R Elisei
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 94:4171-9. 2009
    ..7GBq (131)I (100 mCi) after recombinant human (rh) TSH during T(4) (L-T4) therapy vs. withholding L-T4 (euthyroid vs. hypothyroid groups). We now compared the outcomes of these patients 3.7 yr later...
  8. doi request reprint Routine serum calcitonin measurement in the evaluation of thyroid nodules
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, Pisa, Italy
    Best Pract Res Clin Endocrinol Metab 22:941-53. 2008
    ..The differential diagnosis is possible using previously validated assays against possible sources of interference, and performing stimulation tests with pentagastrin or, eventually, calcium infusion...
  9. ncbi request reprint Low specificity of blood thyroglobulin messenger ribonucleic acid assay prevents its use in the follow-up of differentiated thyroid cancer patients
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:33-9. 2004
    ..On the contrary, serum Tg measurement is a very sensitive and specific thyroid tumor marker, and we recommend that the follow-up of patients affected by DTC must be performed using serum Tg rather than blood Tg mRNA measurement...
  10. ncbi request reprint Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10,864 patients with nodular thyroid disorders
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:163-8. 2004
    ..On this basis, routine measurement of basal serum CT levels should be considered an integral part of the diagnostic evaluation of thyroid nodules...
  11. doi request reprint BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 93:3943-9. 2008
    ..In this study we verified the prognostic value of the BRAF(V600E) mutation in PTC patients with a long-term follow-up...
  12. ncbi request reprint Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 93:682-7. 2008
    ..The aim of this study was to verify the prognostic value of somatic RET mutations in a large series of MTCs with a long follow up...
  13. ncbi request reprint RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:3579-84. 2004
    ..A putative role of the G691S polymorphism as genetic modifier in the normal subjects remains to be established...
  14. ncbi request reprint RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:4725-9. 2007
    ....
  15. ncbi request reprint RET/PTC3 rearrangement and thyroid differentiation gene analysis in a struma ovarii fortuitously revealed by elevated serum thyroglobulin concentration
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    Thyroid 15:1355-61. 2005
    ....
  16. ncbi request reprint New breakpoints in both the H4 and RET genes create a variant of PTC-1 in a post-Chernobyl papillary thyroid carcinoma
    R Elisei
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Clin Endocrinol (Oxf) 53:131-6. 2000
    ....
  17. ncbi request reprint Treatment with drugs able to reduce iodine efflux significantly increases the intracellular retention time in thyroid cancer cells stably transfected with sodium iodide symporter complementary deoxyribonucleic acid
    Rossella Elisei
    Department of Endocrinology and Metabolism, Via Paradisa 2, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 91:2389-95. 2006
    ..One of the major limits of gene therapy with sodium iodide symporter (NIS), which enables cells to be subjected to radioiodine therapy, is that NIS-transfected cells rapidly release the intracellular iodine...
  18. ncbi request reprint All-trans-retinoic acid treatment inhibits the growth of retinoic acid receptor beta messenger ribonucleic acid expressing thyroid cancer cell lines but does not reinduce the expression of thyroid-specific genes
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Clin Endocrinol Metab 90:2403-11. 2005
    ..The finding of a basal and RA-induced RARbeta mRNA expression only in cell lines responding to all-trans-RA suggests that the growth inhibition might be mediated by RARbeta...
  19. ncbi request reprint Retinoic acid receptor beta2 re-expression and growth inhibition in thyroid carcinoma cell lines after 5-aza-2'-deoxycytidine treatment
    F Y Miasaki
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Endocrinol Invest 31:724-30. 2008
    ..A significant reduction of cell growth, but not cell re-differentiation, was also observed after 5-Aza-CdR treatment...
  20. ncbi request reprint Prediction of disease status by recombinant human TSH-stimulated serum Tg in the postsurgical follow-up of differentiated thyroid carcinoma
    F Pacini
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 86:5686-90. 2001
    ....
  21. ncbi request reprint Video assisted prophylactic thyroidectomy and central compartment nodes clearance in two RET gene mutation adult carriers
    P Miccoli
    Department of Surgery, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:557-61. 2004
    ....
  22. ncbi request reprint RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults
    R Elisei
    Departments of Endocrinology and Metabolism, University of Pisa, Pisa 56124, Italy
    J Clin Endocrinol Metab 86:3211-6. 2001
    ..Other factors, probably influenced by ethnic or genetic background, may act independently from or in cooperation with radiation, to trigger the DNA damage leading to RET proto-oncogene activation...
  23. doi request reprint Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role
    E Fiore
    Department of Endocrinology, University of Pisa, Pisa, Italy
    Endocr Relat Cancer 16:1251-60. 2009
    ..Thyroid autonomy conceivably protects against the risk of PTC, while thyroid autoimmunity does not play a significant role...
  24. ncbi request reprint Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an international, randomized, controlled study
    F Pacini
    Section of Endocrinology, Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 91:926-32. 2006
    ..Quality of life was determined at the time of randomization and ablation. After the administration of the 131-I dose, the rate of radiation clearance from blood, thyroid remnant, and whole body was measured...
  25. ncbi request reprint Combined clinical, thyroid ultrasound and cytological features help to predict thyroid malignancy in follicular and Hupsilonrthle cell thyroid lesions: results from a series of 505 consecutive patients
    T Rago
    Department of Endocrinology, University of Pisa, Italy
    Clin Endocrinol (Oxf) 66:13-20. 2007
    ..The diagnostic value of atypia at cytology, clinical parameters and echographic patterns were examined to establish the risk of malignancy in 505 patients with follicular and Hupsilonrthle cell thyroid nodules at cytology...
  26. ncbi request reprint Failure to use measurement of megalin secretory components complexed with serum thyroglobulin as a tool to identify metastases after surgery in papillary thyroid cancer
    S Lisi
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:636-42. 2004
    ..Thus, we concluded that measurement of megalin secretory components is unlikely to be useful to identify the origin of serum Tg in PTC patients after thyroidectomy...
  27. doi request reprint RET genetic screening of sporadic medullary thyroid cancer (MTC) allows the preclinical diagnosis of unsuspected gene carriers and the identification of a relevant percentage of hidden familial MTC (FMTC)
    C Romei
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 74:241-7. 2011
    ..e. gene carriers) who are unaware of their condition...
  28. ncbi request reprint Contralateral papillary thyroid cancer is frequent at completion thyroidectomy with no difference in low- and high-risk patients
    F Pacini
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Thyroid 11:877-81. 2001
    ..On these bases, we believe that PTC should be treated with TT when diagnosed before surgery and submitted to CT, if partial surgery was the initial intervention...
  29. ncbi request reprint Video-assisted central compartment lymphadenectomy in a patient with a positive RET oncogene: initial experience
    P Miccoli
    S Chiara Hospital, University of Pisa, Via Roma 67, 56100, Pisa, Italy
    Surg Endosc 21:120-3. 2007
    ..Video-assisted procedures have been proved feasible for central compartment dissection...
  30. ncbi request reprint N-ras mutation in poorly differentiated thyroid carcinomas: correlation with bone metastases and inverse correlation to thyroglobulin expression
    F Basolo
    Dipartimento di Oncologia, University of Pisa, Italy
    Thyroid 10:19-23. 2000
    ..Interestingly, N-ras mutation was restricted to the group of tumours with low or absent thyroglobulin expression, suggesting that this genetic change is prevalent in less differentiated tumors...
  31. ncbi request reprint Outcome of differentiated thyroid cancer with detectable serum Tg and negative diagnostic (131)I whole body scan: comparison of patients treated with high (131)I activities versus untreated patients
    F Pacini
    Department of Endocrinology and Metabolism, Section of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 86:4092-7. 2001
    ..If positive in the lung, (131)I treatment should be continued up to total remission; surgical treatment should be preferred in patients with node metastases, and no treatment should be used in those with thyroid bed uptake or no uptake...
  32. ncbi request reprint Recombinant human thyrotropin-stimulated serum thyroglobulin combined with neck ultrasonography has the highest sensitivity in monitoring differentiated thyroid carcinoma
    F Pacini
    Section of Endocrinology, Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 88:3668-73. 2003
    ....
  33. ncbi request reprint RET protein expression has no prognostic impact on the long-term outcome of papillary thyroid carcinoma
    F Basolo
    Dipartimento di Oncologia, Universita di Pisa, Via Paradisa, 56124 Pisa, Italy
    Eur J Endocrinol 145:599-604. 2001
    ..CONCLUSION: In conclusion, our analysis indicates that RET expression is frequently found in PTC, and has no influence on tumor outcome...
  34. doi request reprint In silico and in vitro analysis of rare germline allelic variants of RET oncogene associated with medullary thyroid cancer
    B Cosci
    Department of Endocrinology and Metabolism, High Technology Center for the Study of the Environmental Damage of the Endocrine and Nervous Systems, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Endocr Relat Cancer 18:603-12. 2011
    ....
  35. doi request reprint Re-differentiation of thyroid carcinoma cell lines treated with 5-Aza-2'-deoxycytidine and retinoic acid
    A Vivaldi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Mol Cell Endocrinol 307:142-8. 2009
    ....
  36. ncbi request reprint Thyroid consequences of the Chernobyl nuclear accident
    F Pacini
    Department of Endocrinology, University of Pisa, Italy
    Acta Paediatr Suppl 88:23-7. 1999
    ..Therefore, screening programmes for this at-risk population should focus, not only on the detection of thyroid nodules and cancer, but also on the development of thyroid autoimmune diseases...
  37. doi request reprint BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer
    Cristina Romei
    Departments of Endocrinology and Metabolism Oncology Surgery, University of Pisa, 56100 Pisa, Italy
    Endocr Relat Cancer 15:511-20. 2008
    ....
  38. doi request reprint Celecoxib, a cyclooxygenase-2 inhibitor, potentiates the chemotherapic effect of vinorelbine in the medullary thyroid cancer TT cell line
    A Vivaldi
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Mol Cell Endocrinol 355:41-8. 2012
    ..A clinical trial exploring the in vivo activities of celecoxib in MTC patients who cannot benefit from available treatments would be desirable, taking into account the possible risks of cardiovascular effects of this drug...
  39. ncbi request reprint Recombinant human TSH (rhTSH) in 2009: new perspectives in diagnosis and therapy
    E Molinaro
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Q J Nucl Med Mol Imaging 53:490-502. 2009
    ..The aim of this review was to recall how the rhTSH has been developed and progressively introduced in the clinical management of DTC patients...
  40. ncbi request reprint Anaplastic thyroid cancer: prevalence, diagnosis and treatment
    S Chiacchio
    Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy
    Minerva Endocrinol 33:341-57. 2008
    ..Surgery, chemotherapy and radiotherapy are the conventional therapeutic strategies performed in the attempt to improve survival. Unfortunately, very often they do not succeed any clinical benefit but only palliative..
  41. ncbi request reprint Location of functioning metastases from differentiated thyroid carcinoma by simultaneous double isotope acquisition of I-131 whole body scan and bone scan
    C Ceccarelli
    Department of Endocrinology, University of Pisa, Pisa, Italy
    J Endocrinol Invest 27:866-9. 2004
    ..In conclusion, the simultaneous acquisition of images both from I-131 and a bone-seeking agent may be useful to locate functioning bone metastases from DTC...
  42. ncbi request reprint Ablation of thyroid residues with 30 mCi (131)I: a comparison in thyroid cancer patients prepared with recombinant human TSH or thyroid hormone withdrawal
    Furio Pacini
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 87:4063-8. 2002
    ....
  43. ncbi request reprint Medullary and papillary tumors are frequently associated in the same thyroid gland without evidence of reciprocal influence in their biologic behavior
    Rosa Paula Biscolla
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Thyroid 14:946-52. 2004
    ..Moreover, although we cannot completely exclude a shared pathogenic event as the cause of both MTC and PTC, the molecular analysis of RET gene alterations did not show any common mutation...
  44. ncbi request reprint Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma
    Cristiana Lupi
    Departments of Surgery and Endocrinology, University of Pisa, 56126 Pisa, Italy
    J Clin Endocrinol Metab 92:4085-90. 2007
    ....
  45. doi request reprint Follicular-derived neoplasms: morphometric and genetic differences
    A Proietti
    Dipartimento di Patologia Chirurgica, Medica, Molecolare e dell Area Critica, Universita di Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Endocrinol Invest 36:1055-61. 2013
    ..The distinction between follicular adenomas (FAs) and well differentiated follicular and papillary carcinomas is often a demanding task and sometimes only intuitive...
  46. ncbi request reprint Thyroid papillary carcinoma: preliminary evidence for a germ-line single nucleotide polymorphism in the Fas gene
    F Basolo
    Dipartimento di Oncologia, Universita degli Studi di Pisa, 57, Via Roma 56126, Pisa, Italy
    J Endocrinol 182:479-84. 2004
    ..Patients with neoplasia showed the same SNP in tumour tissue, in the unaffected contralateral thyroid lobe, and in peripheral blood cells. Thus, the 988C-->T polymorphism appeared to be of germ-line origin...
  47. ncbi request reprint Minimally invasive video-assisted thyroidectomy for papillary carcinoma: a prospective study of its completeness
    Paolo Miccoli
    Department of Surgery, University of Pisa, S Chiara Hospital, Via Roma 67, 56100 Pisa, Italy
    Surgery 132:1070-3; discussion 1073-4. 2002
    ..Some are concerned about this procedure in patients with thyroid cancer. This prospective study aimed to demonstrate that near-total thyroidectomy can be performed by MIVAT with similar results compared with open thyroidectomy...
  48. ncbi request reprint Diagnostic 131-iodine whole-body scan may be avoided in thyroid cancer patients who have undetectable stimulated serum Tg levels after initial treatment
    F Pacini
    Department of Endocrinology and Metabolism, Section of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 87:1499-501. 2002
    ..These patients may be monitored with clinical examination, neck ultrasound, and serum Tg measurements on L-T(4)...
  49. ncbi request reprint RET proto-oncogene mutations in thyroid carcinomas: clinical relevance
    F Pacini
    Dipartimento di Endocrinologia e Metabolismo, Universita di Pisa, Italy
    J Endocrinol Invest 23:328-38. 2000
    ..Those with the mutation may be treated at a pre-clinical stage of the disease or even before the disease is started. The present review is focused on the clinical implication of RET gene mutations in thyroid cancer patients...
  50. doi request reprint Role of RET codonic mutations in the surgical management of medullary thyroid carcinoma in pediatric age multiple endocrine neoplasm type 2 syndromes
    Claudio Spinelli
    Department of Surgery, University of Pisa, 56126 Pisa, Italy
    J Pediatr Surg 45:1610-6. 2010
    ..The purpose of this study was to evaluate the role of the genetic test in the management of these children and to draw some information about the surgical timing...
  51. doi request reprint Correlation between the BRAF V600E mutation and tumor invasiveness in papillary thyroid carcinomas smaller than 20 millimeters: analysis of 1060 cases
    Fulvio Basolo
    Department of Surgery, Division of Pathology, Via Roma, 57, 56126 Pisa, Italy
    J Clin Endocrinol Metab 95:4197-205. 2010
    ....
  52. pmc Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma
    Fulvio Basolo
    Dipartimento di Oncologia, Universita degli Studi di Pisa, Pisa Fondazione Senatore Pascale, Naples, Italy
    Am J Pathol 160:247-54. 2002
    ..In conclusion, we postulate that the correlation between the RET/PTC rearrangement type and the aggressiveness of human PTC is related to the efficiency with which the oncogene subtype delivers mitogenic signals to thyroid cells...
  53. doi request reprint Surgical treatment of low- and intermediate-risk papillary thyroid cancer with minimally invasive video-assisted thyroidectomy
    Paolo Miccoli
    Department of Surgery, University of Pisa, Via Roma 64, 56100 Pisa, Italy
    J Clin Endocrinol Metab 94:1618-22. 2009
    ..The low number of treated cases and the limited follow-up of these patients represent the major limitations of these studies...
  54. ncbi request reprint Presence of BRAF V600E in very early stages of papillary thyroid carcinoma
    Clara Ugolini
    Department of Surgery, University of Pisa, Pisa, Italy
    Thyroid 17:381-8. 2007
    ..Although IM are in general considered of little clinical significance their potential malignant behavior cannot be ignored. BRAF(V600E) mutation has emerged as the most prevalent genetic alteration in PTC...
  55. ncbi request reprint Galectin-3 and oncofetal-fibronectin expression in thyroid neoplasia as assessed by reverse transcription-polymerase chain reaction and immunochemistry in cytologic and pathologic specimens
    Riccardo Giannini
    Department of Oncology, University of Pisa, Pisa, Italy
    Thyroid 13:765-70. 2003
    ....
  56. ncbi request reprint Lean body mass is a major determinant of levothyroxine dosage in the treatment of thyroid diseases
    Ferruccio Santini
    Department of Endocrinology, University of Pisa, 56124, Pisa, Italy
    J Clin Endocrinol Metab 90:124-7. 2005
    ..An estimate of lean mass may be helpful to shorten the time required to attain a stable dose of l-T(4), particularly in subjects with high body mass index values that may be due either to increased muscular mass or to obesity...
  57. ncbi request reprint Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement
    Fulvio Basolo
    Dipartimento di Oncologia, Universita degli Studi di Pisa, Pisa, Italy
    Int J Cancer 97:608-14. 2002
    ..Moreover, FB-2 cells produced high levels of interleukin (IL)-6 and IL-8...
  58. doi request reprint Thyroid autoantibodies and thyroid function in subjects exposed to Chernobyl fallout during childhood: evidence for a transient radiation-induced elevation of serum thyroid antibodies without an increase in thyroid autoimmune disease
    Laura Agate
    Department of Endocrinology, University of Pisa, Via Paradisa 2, Pisa, Italy
    J Clin Endocrinol Metab 93:2729-36. 2008
    ..An increase in the prevalence of thyroid autoantibodies (ATAs) was reported 6-8 yr after the Chernobyl accident in radiation-exposed children and adolescents...
  59. doi request reprint Acute exogenous TSH administration stimulates leptin secretion in vivo
    Ferruccio Santini
    Department of Endocrinology and Kidney Dulbecco Telethon Institute at Department of Endocrinology and Kidney University Hospital of Pisa, Via Paradisa, 2, 56124 Pisa, Italy
    Eur J Endocrinol 163:63-7. 2010
    ..The role that TSHR activation in adipocytes might play in physiological and pathological conditions remains a matter of investigation...
  60. ncbi request reprint New and old knowledge on differentiated thyroid cancer epidemiology and risk factors
    L Agate
    Department of Endocrinology, University of Pisa, Via Paradisa 2, Pisa, Italy
    J Endocrinol Invest 35:3-9. 2012
    ..However, at present, the favorite hypothesis is that a complex interaction between genetic and environmental factors is required to develop DTC...
  61. ncbi request reprint Interventional bronchoscopy in the treatment of tracheal obstruction secondary to advanced thyroid cancer
    A Ribechini
    Cardio Thoracic Department, Pulmonary Unit, University Hospital of Pisa, Pisa, Italy
    J Endocrinol Invest 29:131-5. 2006
    ..This study is a retrospective report of results of IB performed in patients with severe tracheal obstruction due to advanced thyroid cancer...
  62. ncbi request reprint The heterogeneous distribution of BRAF mutation supports the independent clonal origin of distinct tumor foci in multifocal papillary thyroid carcinoma
    Riccardo Giannini
    Departments of Surgery, University of Pisa, 56126 Pisa, Italy
    J Clin Endocrinol Metab 92:3511-6. 2007
    ..In rare cases, the simultaneous presence of PTC foci of different histopathological subtypes points to independent sites of tumor formation...
  63. ncbi request reprint Multiple endocrine neoplasia type 2 syndromes (MEN 2): results from the ItaMEN network analysis on the prevalence of different genotypes and phenotypes
    Cristina Romei
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Eur J Endocrinol 163:301-8. 2010
    ..The prevalence of these rare genetic diseases and their corresponding RET mutations are unknown due to the small size of the study population...
  64. ncbi request reprint Influence of human body composition on serum peak thyrotropin (TSH) after recombinant human TSH administration in patients with differentiated thyroid carcinoma
    Maria Grazia Castagna
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 90:4047-50. 2005
    ..Furthermore, to verify whether the serum peak TSH influenced the efficacy of radioiodine ((131)I), we compared the rate of thyroid remnant ablation according to the patients' BMI...
  65. ncbi request reprint Congenital hypothyroidism due to a new deletion in the sodium/iodide symporter protein
    Massimo Tonacchera
    Dipartimento di Endocrinologia e Metabolismo, Universita di Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 59:500-6. 2003
    ..When present the defect is also found in the salivary glands and gastric mucosa and it has been shown to arise from abnormalities of the sodium/iodide symporter (NIS)...
  66. doi request reprint Expression analysis of facilitative glucose transporters (GLUTs) in human thyroid carcinoma cell lines and primary tumors
    Raffaele Ciampi
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Mol Cell Endocrinol 291:57-62. 2008
    ..A similar pattern of expression was found for GLUT1 but not for GLUT3 in human thyroid tumors...
  67. ncbi request reprint Biology and clinical application of the NIS gene
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Tumori 89:523-8. 2003
    ..This has demonstrated the feasibility of the in vitro technique but also raised the problem of the absence of the iodide organification machinery in non-thyroidal cells, which, at the moment, represents the major limit of this strategy...
  68. ncbi request reprint Cytotoxic effects of carboplatinum and epirubicin in the setting of an elevated serum thyrotropin for advanced poorly differentiated thyroid cancer
    Ferruccio Santini
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 87:4160-5. 2002
    ..In conclusion, the response rate of poorly differentiated thyroid cancer to chemotherapy observed in this study was favorable and promising. TSH stimulation may have contributed to these results...
  69. ncbi request reprint Simian virus 40-like sequences from early and late regions in human thyroid tumors of different histotypes
    Agnese Vivaldi
    Department of Endocrinology and Metabolism, Section of Endocrinology, University of Pisa School of Medicine, 56100 Pisa, Italy
    J Clin Endocrinol Metab 88:892-9. 2003
    ..The presence of the SV40 footprint in PBMC implies that blood cells are vectors of the virus in other tissues of the host...
  70. pmc Genetic and clinical features of multiple endocrine neoplasia types 1 and 2
    C Romei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Oncol 2012:705036. 2012
    ..MEN 2 prognosis is strictly dependent on the MTC aggressiveness and thus on the success of the initial treatment...
  71. ncbi request reprint Clinically unpredictable prognostic factors in the outcome of medullary thyroid cancer
    Paolo Miccoli
    Department of Surgery, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Endocr Relat Cancer 14:1099-105. 2007
    ....
  72. ncbi request reprint Galectin-3 is highly expressed in nonencapsulated papillary thyroid carcinoma but weakly expressed in encapsulated type; comparison with Hector Battifora mesothelial cell 1 immunoreactivity
    Liborio Torregrossa
    Department of Surgery, Division of Anatomic Pathology, University of Pisa, 56100 Pisa, Italy
    Hum Pathol 38:1482-8. 2007
    ..Our data suggest that gal-3 immunodetection alone is not able to support the diagnosis of encapsulated FVPTCs...
  73. ncbi request reprint Lymphocyte and immature dendritic cell infiltrates in differentiated, poorly differentiated, and undifferentiated thyroid carcinoma
    Clara Ugolini
    Division of Pathology, Department of Surgery, University of Pisa, Pisa, Italy
    Thyroid 17:389-93. 2007
    ..The infiltration of lymphocytes and immature CD1a+ dendritic cells (DC) was characterized in papillary, poorly differentiated (PDC), and undifferentiated (UC) carcinomas to evaluate their association with immunological infiltrates...
  74. ncbi request reprint BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas
    Efisio Puxeddu
    Dipartimento di Medicina Interna, Universita di Perugia, Perugia
    J Clin Endocrinol Metab 89:2414-20. 2004
    ....
  75. ncbi request reprint European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium
    Furio Pacini
    Section of Endocrinology and Metabolism, University of Siena, Via Bracci, 53100 Siena, Italy
    Eur J Endocrinol 154:787-803. 2006
  76. ncbi request reprint Expression of cAMP response element-binding protein and sodium iodide symporter in benign non-functioning and malignant thyroid tumours
    Paola Luciani
    Endocrine Unit, Departm, ent of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Eur J Endocrinol 148:579-86. 2003
    ..In this study we evaluated the expression of CREB and NIS gene in thyroid non-functioning adenomas (n=18) and carcinomas (n=20), as well as in the corresponding normal tissue...
  77. ncbi request reprint Analysis of cancer/testis antigens in sporadic medullary thyroid carcinoma: expression and humoral response to NY-ESO-1
    Michele Maio
    Cancer Bioimmunotherapy Unit, Department of Medical Oncology, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico, 33081 Aviano, Italy
    J Clin Endocrinol Metab 88:748-54. 2003
    ..Serological survey may be useful as a way to identify patients with humoral immune response to NY-ESO-1 that provide a new attractive target for vaccine-based immunotherapy of MTC...