Gino Doria

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi request reprint Role of immune responsiveness and DNA repair capacity genes in ageing
    Gino Doria
    Laboratory of Immunology, Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Ageing Res Rev 3:143-51. 2004
  2. ncbi request reprint DNA damage recognition and repair capacities in human naïve and memory T cells from peripheral blood of young and elderly subjects
    Salvatore Scarpaci
    Department of Biology, University of Rome Tor Vergata, Laboratory of Immunology, Via della Ricerca Scientifica, 00133, Rome, Italy
    Mech Ageing Dev 124:517-24. 2003
  3. doi request reprint APC activation by IFN-alpha decreases regulatory T cell and enhances Th cell functions
    Luigia Pace
    Immunology Laboratory, Department of Biology, University of Rome Tor Vergata, Rome, Italy
    J Immunol 184:5969-79. 2010
  4. ncbi request reprint Cutting edge: IL-4-induced protection of CD4+CD25- Th cells from CD4+CD25+ regulatory T cell-mediated suppression
    Luigia Pace
    Department of Biology, University of Rome Tor Vergata, Italy
    J Immunol 176:3900-4. 2006
  5. ncbi request reprint The DNA repair protein ku is involved in gp130-mediated signal transduction events in PBMC from young but not from elderly subjects
    Daniela Frasca
    Laboratory of Immunology, ENEA C R Casaccia, AMB PRO TOSS, Via Anguillarese 301, 00060 S Maria di Galeria, Rome, Italy
    Exp Gerontol 37:321-8. 2002
  6. ncbi request reprint IL-4 modulation of CD4+CD25+ T regulatory cell-mediated suppression
    Luigia Pace
    Laboratory of Immunology, Department of Biology, University of Rome Tor Vergata, Italy
    J Immunol 174:7645-53. 2005
  7. pmc CTLA-4 engagement inhibits Th2 but not Th1 cell polarisation
    Vanessa Ubaldi
    Department of Biology, University of Tor Vergata, 1 00133, Rome, Italy
    Clin Dev Immunol 10:13-7. 2003

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Role of immune responsiveness and DNA repair capacity genes in ageing
    Gino Doria
    Laboratory of Immunology, Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Ageing Res Rev 3:143-51. 2004
    ..This finding helps to elucidate questions related to the impairment of DNA repair during ageing...
  2. ncbi request reprint DNA damage recognition and repair capacities in human naïve and memory T cells from peripheral blood of young and elderly subjects
    Salvatore Scarpaci
    Department of Biology, University of Rome Tor Vergata, Laboratory of Immunology, Via della Ricerca Scientifica, 00133, Rome, Italy
    Mech Ageing Dev 124:517-24. 2003
    ..These findings may account for the higher genomic stability and longer lifespan of nai;ve as compared to memory human T cells from young subjects...
  3. doi request reprint APC activation by IFN-alpha decreases regulatory T cell and enhances Th cell functions
    Luigia Pace
    Immunology Laboratory, Department of Biology, University of Rome Tor Vergata, Rome, Italy
    J Immunol 184:5969-79. 2010
    ..Altogether, these findings indicate that through a direct effect on APC activation and by affecting CD4(+)CD25(+) Treg cell-mediated suppression, IFN-alpha sustains and drives CD4(+)CD25(-) Th cell activation...
  4. ncbi request reprint Cutting edge: IL-4-induced protection of CD4+CD25- Th cells from CD4+CD25+ regulatory T cell-mediated suppression
    Luigia Pace
    Department of Biology, University of Rome Tor Vergata, Italy
    J Immunol 176:3900-4. 2006
    ..These findings support an essential role of IL-4 signaling for CD4(+)CD25(-) Th cell activation and indicate that IL-4-induced proliferation of CD4(+)CD25(+) Treg cells is compatible with their suppressive activity...
  5. ncbi request reprint The DNA repair protein ku is involved in gp130-mediated signal transduction events in PBMC from young but not from elderly subjects
    Daniela Frasca
    Laboratory of Immunology, ENEA C R Casaccia, AMB PRO TOSS, Via Anguillarese 301, 00060 S Maria di Galeria, Rome, Italy
    Exp Gerontol 37:321-8. 2002
    ..This association was independent of PHA stimulation. Moreover, the present results indicate that after gp130 signaling both Tyk-2 and ku 80 are phosphorylated, suggesting their activation by K-7/D-6...
  6. ncbi request reprint IL-4 modulation of CD4+CD25+ T regulatory cell-mediated suppression
    Luigia Pace
    Laboratory of Immunology, Department of Biology, University of Rome Tor Vergata, Italy
    J Immunol 174:7645-53. 2005
    ..These results indicate that although CD4(+)CD25(+) Treg cells inhibit IL-4 production, the addition of IL-4 counteracts CD4(+)CD25(+) Treg cell-mediated suppression by promoting CD4(+)CD25(-) Th cell survival and proliferation...
  7. pmc CTLA-4 engagement inhibits Th2 but not Th1 cell polarisation
    Vanessa Ubaldi
    Department of Biology, University of Tor Vergata, 1 00133, Rome, Italy
    Clin Dev Immunol 10:13-7. 2003
    ..Altogether these data indicate that CTLA-4 may interfere not only in the signalling involved in acute transcriptional activation of both Th1 and Th2 cells but also in the development of one of the Th cell subsets...