G Donofrio

Summary

Affiliation: University of Parma
Country: Italy

Publications

  1. ncbi Potential of bovine herpesvirus 4 as a gene delivery vector
    Gaetano Donofrio
    Facolta di Medicina Veterinaria, Sezione di Malattie Infettive degli Animali, Dipartimento di Salute Animale, Universita degli Studi di Parma, Via del Taglio 8, 43100, Parma, Italy
    J Virol Methods 101:49-61. 2002
  2. ncbi In vivo image analysis of BoHV-4-based vector in mice
    Valentina Franceschi
    Department of Medical Veterinary Science, University of Parma, Parma, Italy
    PLoS ONE 9:e95779. 2014
  3. pmc In vivo imaging of transiently transgenized mice with a bovine interleukin 8 (CXCL8) promoter/luciferase reporter construct
    Fabio Franco Stellari
    Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Universita di Parma, Parma, Italy
    PLoS ONE 7:e39716. 2012
  4. pmc Arginine clustering on calix[4]arene macrocycles for improved cell penetration and DNA delivery
    Valentina Bagnacani
    Dipartimento di Chimica, Universita degli Studi di Parma, Parma, Italy
    Nat Commun 4:1721. 2013
  5. ncbi Enlightened Mannhemia haemolytica lung inflammation in bovinized mice
    Fabio Franco Stellari
    Department of Medical Veterinary Science, University of Parma, Via del Taglio 10, 43126 Parma, Italy
    Vet Res 45:8. 2014
  6. pmc Bovine herpesvirus 4 glycoprotein B is indispensable for lytic replication and irreplaceable by VSVg
    Valentina Franceschi
    Dipartimento di Scienze Medico Veterinarie, Universita di Parma, Via del Taglio 10, 43126, Parma, Italy
    BMC Vet Res 9:6. 2013
  7. pmc Clinical protection of goats against CpHV-1 induced genital disease with a BoHV-4-based vector expressing CpHV-1 gD
    Gaetano Donofrio
    Department of Medical Veterinary Science, University of Parma, Parma, Italy
    PLoS ONE 8:e52758. 2013
  8. pmc Herpes simplex virus type 1 thymidine kinase-armed bovine herpesvirus type 4-based vector displays enhanced oncolytic properties in immunocompetent orthotopic syngenic mouse and rat glioma models
    Marco Redaelli
    Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Universita di Parma, via del Taglio 8 43126 Parma, Italy
    Neuro Oncol 14:288-301. 2012
  9. pmc Bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma
    Marco Redaelli
    Department of Animal Health, University of Parma, Italy
    Virol J 7:298. 2010
  10. pmc Isolation and characterization of a strain of Lichtheimia corymbifera (ex Absidia corymbifera) from a case of bovine abortion
    Chiara Piancastelli
    Dipartimento di Salute Animale, Parma University, 43126 Parma, Italy
    Reprod Biol Endocrinol 7:138. 2009

Collaborators

Detail Information

Publications54

  1. ncbi Potential of bovine herpesvirus 4 as a gene delivery vector
    Gaetano Donofrio
    Facolta di Medicina Veterinaria, Sezione di Malattie Infettive degli Animali, Dipartimento di Salute Animale, Universita degli Studi di Parma, Via del Taglio 8, 43100, Parma, Italy
    J Virol Methods 101:49-61. 2002
    ....
  2. ncbi In vivo image analysis of BoHV-4-based vector in mice
    Valentina Franceschi
    Department of Medical Veterinary Science, University of Parma, Parma, Italy
    PLoS ONE 9:e95779. 2014
    ..These data, that add a new insight on the biology of BoHV-4 in vivo, provide the first indication for the potential use of a BoHV-4-based vector in gene-transfer in the liver. ..
  3. pmc In vivo imaging of transiently transgenized mice with a bovine interleukin 8 (CXCL8) promoter/luciferase reporter construct
    Fabio Franco Stellari
    Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Universita di Parma, Parma, Italy
    PLoS ONE 7:e39716. 2012
    ..This proof of principle study has the potential to be utilized also for studying primate IL-8 promoter regions...
  4. pmc Arginine clustering on calix[4]arene macrocycles for improved cell penetration and DNA delivery
    Valentina Bagnacani
    Dipartimento di Chimica, Universita degli Studi di Parma, Parma, Italy
    Nat Commun 4:1721. 2013
    ..These new macrocyclic carriers show high efficiency in DNA delivery and transfection in a variety of cell lines...
  5. ncbi Enlightened Mannhemia haemolytica lung inflammation in bovinized mice
    Fabio Franco Stellari
    Department of Medical Veterinary Science, University of Parma, Via del Taglio 10, 43126 Parma, Italy
    Vet Res 45:8. 2014
    ..Using a bovine IL-8/luciferase transiently transgenized mouse model, the orchestration among M. haemolytica, IL-8 promoter activation and neutrophilia was followed in real time by in vivo image analysis. ..
  6. pmc Bovine herpesvirus 4 glycoprotein B is indispensable for lytic replication and irreplaceable by VSVg
    Valentina Franceschi
    Dipartimento di Scienze Medico Veterinarie, Universita di Parma, Via del Taglio 10, 43126, Parma, Italy
    BMC Vet Res 9:6. 2013
    ..Here we describe the generation of several tagged soluble forms of gB ectodomain, in order to test their ability to neutralize BoHV-4 infection...
  7. pmc Clinical protection of goats against CpHV-1 induced genital disease with a BoHV-4-based vector expressing CpHV-1 gD
    Gaetano Donofrio
    Department of Medical Veterinary Science, University of Parma, Parma, Italy
    PLoS ONE 8:e52758. 2013
    ..In summary, the data acquired in the present study validate BoHV-4-based vector as a safe and effective viral vector for goat vaccination against CpHV-1 induced genital disease and pave the way for further applications...
  8. pmc Herpes simplex virus type 1 thymidine kinase-armed bovine herpesvirus type 4-based vector displays enhanced oncolytic properties in immunocompetent orthotopic syngenic mouse and rat glioma models
    Marco Redaelli
    Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Universita di Parma, via del Taglio 8 43126 Parma, Italy
    Neuro Oncol 14:288-301. 2012
    ..This article represents the result of a mutual interaction between human medical science and veterinary science, a combination of scientific knowledge often neglected...
  9. pmc Bovine herpesvirus 4 based vector as a potential oncolytic-virus for treatment of glioma
    Marco Redaelli
    Department of Animal Health, University of Parma, Italy
    Virol J 7:298. 2010
    ..Although virus expression was scattered across the tumour mass, it was mainly located in the peripheral area of larger gliomas. These data support BoHV-4 as a candidate vector for glioma treatment...
  10. pmc Isolation and characterization of a strain of Lichtheimia corymbifera (ex Absidia corymbifera) from a case of bovine abortion
    Chiara Piancastelli
    Dipartimento di Salute Animale, Parma University, 43126 Parma, Italy
    Reprod Biol Endocrinol 7:138. 2009
    ..Serological examinations were performed on fetal and mother's blood. One of the aborted fetus was referred to our laboratory. The paper describes the isolation and characterization of Lichtheimia corymbifera from a bovine aborted fetus...
  11. pmc Virally and physically transgenized equine adipose-derived stromal cells as a cargo for paracrine secreted factors
    Gaetano Donofrio
    Dipartimento di Salute Animale, Sezione di Malattie Infettive, Facolta di Medicina Veterinaria, Via del Taglio 10, 43100 Parma, Italy
    BMC Cell Biol 11:73. 2010
    ..Their use has been proposed for the therapy of joint diseases and tendon injuries in the horse. In the present report the genetic manipulation of Equine Adipose-Derived Stromal Cells has been investigated...
  12. pmc Bovine herpesvirus 4 is tropic for bovine endometrial cells and modulates endocrine function
    Gaetano Donofrio
    Dipartimento di Salute Animale, Sezione di Malattie Infettive, Facolta di Medicina Veterinaria, Via del Taglio 8, 43100 Parma, Italy
    Reproduction 134:183-97. 2007
    ..In conclusion, the present study provides evidence of cellular and molecular mechanisms, supporting the concept that BoHV-4 is a pathogen associated with uterine disease...
  13. ncbi Generation of a transposon insertion mutant library for bovine herpesvirus 4 cloned as a bacterial artificial chromosome by in vitro MuA based DNA transposition system
    Gaetano Donofrio
    Universita di Parma, Facolta di Medicina Veterinaria, Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Via del Taglio 8, 43100 Parma, Italy
    J Virol Methods 141:63-70. 2007
    ..BoHV-4 functional analysis information is fundamental when the BoHV-4 genome is modified for vector purposes...
  14. pmc Integration of bovine herpesvirus 4 genome into cultured persistently infected host cell genome
    Gaetano Donofrio
    Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Universita di Parma, Via del Taglio 10, 43100 Parma, Italy
    Virol J 7:246. 2010
    ..In the present study, we used fluorescent in situ hybridization (FISH) to demonstrate BoHV-4 genomes also integrated into the genomes of these persistently infected cells...
  15. pmc Establishment of a bovine herpesvirus 4 based vector expressing a secreted form of the bovine viral diarrhoea virus structural glycoprotein E2 for immunization purposes
    Gaetano Donofrio
    Universita di Parma, Facolta di Medicina Veterinaria, Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Via del Taglio 8, 43100 Parma, Italy
    BMC Biotechnol 7:68. 2007
    ....
  16. doi Assessment of bovine herpesvirus 4 based vector in chicken
    Gaetano Donofrio
    Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Facolta di Medicina Veterinaria, 43100 Parma, Italy
    J Virol Methods 148:303-6. 2008
    ..An immune response could be produced against heterologous antigen delivered by a recombinant BoHV-4. These data suggest the feasibility of using BoHV-4 based vector for vaccination purposes in chickens...
  17. pmc Bacterial infection of endometrial stromal cells influences bovine herpesvirus 4 immediate early gene activation: a new insight into bacterial and viral interaction for uterine disease
    Gaetano Donofrio
    Dipartimento di Salute Animale, Facolta di Medicina Veterinaria, Universita di Parma, Sezione di Malattie Infettive degli Animali, Via del Taglio 8, 43100 Parma, Italy
    Reproduction 136:361-6. 2008
    ..coli or its lipopolysaccharide upregulated the IE2 gene promoter in uterine cells. Bacterial co-infection is important for BoHV-4 uterine disease...
  18. pmc Cellular targeting of engineered heterologous antigens is a determinant factor for bovine herpesvirus 4-based vaccine vector development
    Gaetano Donofrio
    Department of Animal Health, Sezione di Malattie Infettive degli Animali, Facolta di Medicina Veterinaria, University of Parma, Parma, Italy
    Clin Vaccine Immunol 16:1675-86. 2009
    ..Protein cell sorting and targeting are a very important issue when immunodominant antigens are engineered for recombinant virus vaccine development...
  19. pmc Isolation and characterization of bovine herpesvirus 4 (BoHV-4) from a cow affected by post partum metritis and cloning of the genome as a bacterial artificial chromosome
    Gaetano Donofrio
    Dipartimento di Salute Animale, Facolta di Medicina Veterinaria, Universita di Parma, Via del Taglio 10, 43100 Parma, Italy
    Reprod Biol Endocrinol 7:83. 2009
    ..To explore the mechanistic role of viral strain variation for uterine disease, the present study aimed to develop a tool enabling precise genetic discrimination between strains of BoHV-4 and to easily manipulate the viral genome...
  20. pmc Bovine endometrial stromal cells display osteogenic properties
    Gaetano Donofrio
    Universita di Parma, Facolta di Medicina Veterinaria, Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Via del Taglio 8, 43100 Parma, Italy
    Reprod Biol Endocrinol 6:65. 2008
    ..These observations pave the way for further investigation of the mechanisms of stroma cell differentiation in the bovine reproductive tract...
  21. doi Double immunization strategy with a BoHV-4-vectorialized secreted chimeric peptide BVDV-E2/BoHV-1-gD
    G Donofrio
    Universita di Parma, Facolta di Medicina Veterinaria, Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Via del Taglio 10, Parma, Italy
    Vaccine 26:6031-42. 2008
    ..Thus, this work has implications for the development of safe and effective polyvalent vaccines...
  22. pmc Recombinant bovine herpesvirus 4 (BoHV-4) expressing glycoprotein D of BoHV-1 is immunogenic and elicits serum-neutralizing antibodies against BoHV-1 in a rabbit model
    Gaetano Donofrio
    Dipartimento di Salute Animale, Sezione di Malattie Infettive, Facolta di Medicina Veterinaria, Via del Taglio 8, 43100 Parma, Italy
    Clin Vaccine Immunol 13:1246-54. 2006
    ..This work is one of the first demonstrations of the use BoHV-4 as a vector for vaccine purposes and may provide the basis for BoHV-1 vaccination of cattle with recombinant BoHV-4...
  23. doi The chemokine IL8 is up-regulated in bovine endometrial stromal cells by the BoHV-4 IE2 gene product, ORF50/Rta: a step ahead toward a mechanism for BoHV-4 induced endometritis
    Gaetano Donofrio
    Sezione di Malattie Infettive degli Animali, Dipartimento di Salute Animale, Facolta di Medicina Veterinaria, Universita di Parma, Parma, Italy
    Biol Reprod 83:919-28. 2010
    ..These observations may represent an endometrial defense mechanism against viral infection or a virulence mechanism by which viral replication stimulates chemokine secretion to attract more susceptible host cells to the endometrium...
  24. ncbi Interaction of a green recombinant bovine herpesvirus 4 with in vitro-produced bovine embryos
    G Donofrio
    Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Facolta di Medicina Veterinaria, Universita degli Studi di Parma, Via del Taglio 8, 43100 Parma, Italy
    Vet Res Commun 27:415-24. 2003
    ..However, embryonic stem cells could be transduced by BHV-4EGFP deltaTK just after differentiation, as shown by expression of EGFP...
  25. ncbi Activation of bovine herpesvirus 4 lytic replication in a non-permissive cell line by overexpression of BoHV-4 immediate early (IE) 2 gene
    Gaetano Donofrio
    Sezione di Malattie Infettive degli Animali, Dipartimento di Salute Animale, Via del Taglio 8, Parma 43100, Italy
    J Virol Methods 116:203-7. 2004
    ..BoHV-4 IE2 induced an increased production of infectious viral particles sufficient to obtain an apparent cytopathic effect. It is concluded that BoHV-4 IE2 is a key factor in determining the outcome of BoHV-4 infection...
  26. ncbi Bovine herpesvirus 4 infects differentiated neuronal cells in culture and establish persistent infection upon selection
    Gaetano Donofrio
    Sezione di Malattie Infettive degli Animali, Dipartimento di Salute Animale, Parma, Italy
    J Neurovirol 10:123-30. 2004
    ..BoHV-4 persistently infected N2a cells produce infectious viral particles, which do not interfere with cellular differentiation...
  27. pmc Expression of bovine viral diarrhea virus glycoprotein E2 as a soluble secreted form in a Mammalian cell line
    Gaetano Donofrio
    Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Facolta di Medicina Veterinaria, Via del Taglio 8, 43100 Parma, Italy
    Clin Vaccine Immunol 13:698-701. 2006
    ..The crude conditioned medium containing secE2 can be potentially employed to develop an enzyme-linked immunosorbent assay antigen for the diagnosis of BVDV infection or for vaccine purposes...
  28. pmc Potential secondary pathogenic role for bovine herpesvirus 4
    Gaetano Donofrio
    Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Facolta di Medicina Veterinaria, Via del Taglio 8, 43100 Parma, Italy
    J Clin Microbiol 43:3421-6. 2005
    ..Because opportunistic infection can increase PGE2 production, we propose a link between opportunistic infection, PGE2 production, and BoHV-4 replication...
  29. ncbi Outcome of bovine herpesvirus 4 infection following direct viral injection in the lateral ventricle of the mouse brain
    Gaetano Donofrio
    Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Universita di Parma, Via del Taglio 8, 43100 Parma, Italy
    Microbes Infect 8:898-904. 2006
    ....
  30. ncbi Bovine herpesvirus 4 based vector interaction with liver cells in vitro and in vivo
    Gaetano Donofrio
    Dipartimento di Salute Animale, Facolta di Medicina Veterinaria, Sezione di Malattie Infettive degli Animali, Universita di Parma, Via del Taglio 8, 43100 Parma, Italy
    J Virol Methods 136:126-36. 2006
    ..The present study serves as a starting point for study of the use of BoHV-4 based vectors to target gene delivery to vascular endothelial cells...
  31. ncbi Molecular typing of a BHV-4 (bovine herpesvirus 4) field isolate
    G Donofrio
    Istituto di Malattie Infettive Profilassi e Polizia Veterinaria, Facolta di Medicina Veterinaria, Universita di Parma, Italy
    Vet Res Commun 24:411-22. 2000
    ..Taken together, these data show that PR/ 1 is a new BHV-4. We would consider that the present report provides a scheme of work for diagnosis and typing of BHV-4 isolates...
  32. ncbi Seroprevalence to bovine immunodeficiency virus and lack of association with leukocyte counts in Italian dairy cattle
    S Cavirani
    Istituto di Malattie Infettive, Profilassi e Polizia Veterinaria, Facolta di Medicina Veterinaria, Universita di Parma, Via del Taglio, Parma, Italy
    Prev Vet Med 37:147-57. 1998
    ..No significant differences were detected between the two groups. These data indicate that BIV infection is present in Italian dairy cattle--but the role of BIV in inducing disease remains unclear...
  33. doi Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction
    P Storti
    Hematology, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy
    Leukemia 27:1697-706. 2013
    ..Overall, our data indicate that HIF-1α suppression in MM cells significantly blocks MM-induced angiogenesis and reduces MM tumor burden and bone destruction in vivo, supporting HIF-1α as a potential therapeutic target in MM. ..
  34. ncbi Exploiting persistent infection for selection of bovine herpesvirus 4 recombinants
    G Donofrio
    Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Facolta di Medicina Veterinaria, Universita di Parma, Via del Taglio 8, 43100 Parma, Italy
    J Virol Methods 128:6-13. 2005
    ..A tool for selecting BoHV-4 recombinants was developed by drug positive selection...
  35. doi p21(Waf1/Cip1) as a molecular sensor for BoHV-4 replication
    A Capocefalo
    Facolta di Medicina Veterinaria, Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Parma, Italy
    J Virol Methods 161:308-11. 2009
    ..Thus p21 expression reports on BoHV-4 replication and could represent a host cell defensive response to infection-associated cellular damage...
  36. ncbi A bovine macrophage cell line supports bovine herpesvirus-4 persistent infection
    G Donofrio
    Istituto di Malattie Infettive Veterinarie, , Universita degli Studi di Parma, 43100 Parma, Italy
    J Gen Virol 82:1181-5. 2001
    ..This suggests that reactivation of latent BHV-4 by dexamethasone in vivo might involve direct action of dexamethasone on latently infected cells...
  37. ncbi Association between Chlamydia psittaci seropositivity and abortion in Italian dairy cows
    S Cavirani
    Facolta di Medicina Veterinaria, Istituto di Malattie Infettive, Profilassi e Polizia Veterinaria, Universita degli Studi di Parma, Via del Taglio, 8, 43100, Parma, Italy
    Prev Vet Med 50:145-51. 2001
    ..The true seroprevalence (45%) in aborted cows was significantly higher than that in the control group (24%) (adjusted odds ratio=2.53)...
  38. ncbi Susceptibility of bovine mesenchymal stem cells to bovine herpesvirus 4
    G Donofrio
    Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Facolta di Medicina Veterinaria, Via del Taglio 8, 43100 Parma, Italy
    J Virol Methods 127:168-70. 2005
    ..Primary bovine mesenchymal stem cells were highly permissive to support full replication of BoHV-4. This finding could be considered a new important step in studies on the potential pathogenesis related to BoHV-4...
  39. doi Myeloma cells inhibit non-canonical wnt co-receptor ror2 expression in human bone marrow osteoprogenitor cells: effect of wnt5a/ror2 pathway activation on the osteogenic differentiation impairment induced by myeloma cells
    M Bolzoni
    Hematology and BMT Center, University of Parma, Parma, Italy
    Leukemia 27:451-63. 2013
    ....
  40. pmc Detection of bovine herpesvirus 4 (BoHV-4) DNA in the cell fraction of milk of dairy cattle with history of BoHV-4 infection
    G Donofrio
    Istituto di Malattie Infettive Profilassi e Polizia Veterinaria, Facolta di Medicina Veterinaria, Universita di Parma, 43100 Parma, Italy
    J Clin Microbiol 38:4668-71. 2000
    ..This report shows that infectious BoHV-4 can be present in milk cells and that therefore nursing may be one of the transmission routes of BoHV-4...
  41. ncbi Association between Neospora caninum antibodies and blue tongue vaccination in dairy cows
    S Cavirani
    Department of Animal Health, Faculty of Veterinary Medicine, University of Parma, Via del Taglio 8, 43100, Parma, Italy
    Vet Res Commun 29:233-6. 2005
  42. doi Expression and secretion of Bluetongue virus serotype 8 (BTV-8)VP2 outer capsid protein by mammalian cells
    A Capocefalo
    Dipartimento di Salute Animale, Facolta di Medicina Veterinaria, Universita di Parma, Via del Taglio 10, 43100 Parma, Italy
    J Virol Methods 169:420-4. 2010
    ..The crude conditioned medium containing the secreted peptide could be employed for immunodiagnostic assay development or vaccine purposes...
  43. doi Thermodynamics and biological properties of the aqueous solutions of new glucocationic surfactants
    Emilia Fisicaro
    Dipartimento di Scienze Farmacologiche, Biologiche e Chimiche Applicate, Universita di Parma, Viale G P Usberti, 27 A 43100 Parma, Italy
    J Phys Chem B 112:9360-70. 2008
    ..Only C16AGCB is able to deliver little DNA inside cells when coformulated with DOPE, as shown by the transient transfection assay. This might be related to the ability of C16AGCB to form surfactant-rich domains in the lipid structure...
  44. ncbi Biologically active bisquaternary ammonium chlorides: physico-chemical properties of long chain amphiphiles and their evaluation as non-viral vectors for gene delivery
    Emilia Fisicaro
    Dipartimento di Scienze Farmacologiche, Biologiche e Chimiche Applicate, Universita di Parma, Parco Area delle Scienze, 27A 43100 Parma, Italy
    Biochim Biophys Acta 1722:224-33. 2005
    ..Bis-C10BEC and bis-C12BEC show a slight fluidizing effect, while bis-C14BEC increases stability of both the gel and the rippled gel phases...
  45. doi Short communication: characterization of a monoclonal antibody for kappa-casein B of cow's milk
    A Summer
    Department of Animal Production, Veterinary Biotechnologies, Food Quality and Safety, University of Parma, Via del Taglio 10, 43126 Parma, Italy
    J Dairy Sci 93:796-800. 2010
    ..In conclusion, antik-B was specific to kappa-CN B in milk and it seemed to be reactive toward all its isoforms...
  46. ncbi Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment
    Nicola Giuliani
    Hematology and Bone Marrow Transplantation Center, Department of Internal Medicine and Biomedical Science, University of Parma, Parma, Italy
    Cancer Res 67:7665-74. 2007
    ....
  47. ncbi DNA condensation and cell transfection properties of guanidinium calixarenes: dependence on macrocycle lipophilicity, size, and conformation
    Francesco Sansone
    Dipartimento di Chimica Organica e Industriale, Universita degli Studi, Viale G P Usberti 17 a, 43100 Parma, Italy
    J Am Chem Soc 128:14528-36. 2006
    ..Finally, calix[4]arenes in a 1,3-alternate conformation show an intermediate behavior because they condense DNA, but the process is driven by charge-charge interactions...
  48. ncbi Isolation of Bartonella henselae from domestic cats in an Italian urban area
    C S Cabassi
    Dipartimento di Salute Animale, Facolta di Medicina Veterinaria, Universita di Parma, Italy
    New Microbiol 25:253-7. 2002
    ..24 (9.7 %) cats were found bacteriemic, most of which aged <1 year. A higher sensitivity was demonstrated by cultural method compared with PCR...
  49. doi Macrocyclic nonviral vectors: high cell transfection efficiency and low toxicity in a lower rim guanidinium calix[4]arene
    Valentina Bagnacani
    Dipartimento di Chimica Organica e Industriale, Universita di Parma, V le G P Usberti 17 A, 43100 Parma, Italy
    Org Lett 10:3953-6. 2008
    ..New multivalent cationic lipids, one of them showing high efficiency and low toxicity in cell transfection, have been obtained by attaching guanidinium groups at the lower rim of calix[4]arenes...
  50. ncbi Expression of c-myc is down-regulated as mouse mammary epithelial cells become confluent
    S Grolli
    Facolta di Medicina Veterinaria, Universita de Parma, Parma, 43100, Italy
    Biochem Biophys Res Commun 239:566-9. 1997
    ..Finally, we demonstrate that suppression of c-myc expression occurs when HC11 cells growth-arrest as they become confluent...
  51. ncbi Association between Coxiella burnetii seropositivity and abortion in dairy cattle of Northern Italy
    Clotilde S Cabassi
    Universita di Parma, Dipartimento di Salute Animale, Parma, Italy
    New Microbiol 29:211-4. 2006
    ..001). Moreover, a significant higher prevalence was disclosed in cattle which aborted during late gestation (p < 0.002) and in the autumn (p < 0.001)...
  52. ncbi The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesi
    Simona Colla
    Hematology and Bone Marrow Transplantation Center, University of Parma, Parma, Italy
    Blood 110:4464-75. 2007
    ..Our data indicate that ING4 exerts an inhibitory effect on the production of proangiogenic molecules and consequently on MM-induced angiogenesis...
  53. ncbi First Serbian isolates of bovine herpesvirus 4 (BoHV-4) from a herd with a history of postpartum metritis
    Veljko M Nikolin
    Department of Virology, The Institute of Veterinary Medicine of Serbia, Belgrade, Belgrade, Serbia
    New Microbiol 30:53-7. 2007
    ..Two isolates showed similarity with MOVAR 33/63 virus type, but one differed in polyrepetitive and other parts of DNA. This was the first isolation and characterisation of BoHV4 from Serbian herds...
  54. pmc Paracrine inhibition of prion propagation by anti-PrP single-chain Fv miniantibodies
    Gaetano Donofrio
    Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    J Virol 79:8330-8. 2005
    ..Because of their small size and their monovalent binding, scFv fragments may represent candidates for gene transfer-based immunotherapy of prion diseases...