Sandra Donnini

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. ncbi request reprint Prevention of ischemic brain injury by treatment with the membrane penetrating apoptosis inhibitor, TAT-BH4
    Sandra Donnini
    Department of Molecular Biology, University of Siena, via Moro 2, Siena, Italy
    Cell Cycle 8:1271-8. 2009
  2. doi request reprint Peroxynitrite inactivates human-tissue inhibitor of metalloproteinase-4
    Sandra Donnini
    Departments of Molecular Biology, University of Siena, Via A Moro, 2, Siena 53100, Italy
    FEBS Lett 582:1135-40. 2008
  3. doi request reprint Prostaglandin E(2) primes the angiogenic switch via a synergic interaction with the fibroblast growth factor-2 pathway
    Federica Finetti
    Department of Molecular Biology, University of Siena, and Istituto Toscano Tumori, Italy
    Circ Res 105:657-66. 2009
  4. pmc PKCε activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting
    Martina Monti
    Department of Life Sciences, University of Siena, 53100 Siena, Italy
    J Mol Cell Cardiol 63:107-17. 2013
  5. ncbi request reprint Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1
    Federica Finetti
    Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy
    J Biol Chem 283:2139-46. 2008
  6. doi request reprint Sulfhydryl angiotensin-converting enzyme inhibitor promotes endothelial cell survival through nitric-oxide synthase, fibroblast growth factor-2, and telomerase cross-talk
    Sandra Donnini
    Section of Pharmacology, Department of Molecular Biology, University of Siena, Via A Moro 2, 53100 Siena, Italy
    J Pharmacol Exp Ther 332:776-84. 2010
  7. pmc Pharmacological inhibition of microsomal prostaglandin E synthase-1 suppresses epidermal growth factor receptor-mediated tumor growth and angiogenesis
    Federica Finetti
    Department of Biotechnology, University of Siena, Via Aldo Moro, 2, Siena, and Istituto Toscano Tumori ITT, Italy
    PLoS ONE 7:e40576. 2012
  8. ncbi request reprint Divergent effects of quercetin conjugates on angiogenesis
    Sandra Donnini
    Section of Pharmacology, Department of Molecular Medicine, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Br J Nutr 95:1016-23. 2006
  9. doi request reprint Inhibition of hypoxia inducible factor-1alpha by dihydroxyphenylethanol, a product from olive oil, blocks microsomal prostaglandin-E synthase-1/vascular endothelial growth factor expression and reduces tumor angiogenesis
    Erika Terzuoli
    Department of Molecular Biology, University of Siena, Siena, Italy
    Clin Cancer Res 16:4207-16. 2010
  10. ncbi request reprint Pyrazolo-pyrimidine-derived c-Src inhibitor reduces angiogenesis and survival of squamous carcinoma cells by suppressing vascular endothelial growth factor production and signaling
    Sandra Donnini
    Dipartimento di Biologia Molecolare, Universita degli Studi di Siena, Via Aldo Moro, 2, 53100, Siena, Italy
    Int J Cancer 120:995-1004. 2007

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Prevention of ischemic brain injury by treatment with the membrane penetrating apoptosis inhibitor, TAT-BH4
    Sandra Donnini
    Department of Molecular Biology, University of Siena, via Moro 2, Siena, Italy
    Cell Cycle 8:1271-8. 2009
    ..These findings indicate that TAT-BH4 administration protects against acute hypoxia/ischemia injury in the brain by preventing endothelial and neuron cell apoptosis and by inducing neuronal plasticity...
  2. doi request reprint Peroxynitrite inactivates human-tissue inhibitor of metalloproteinase-4
    Sandra Donnini
    Departments of Molecular Biology, University of Siena, Via A Moro, 2, Siena 53100, Italy
    FEBS Lett 582:1135-40. 2008
    ..HPLC/ESI-MS/MS analysis of peroxynitrite-treated TIMP-4 showed modifications at Y114, Y195, Y188 and Y190. In conclusion, TIMP-4 nitration might be a potential mechanism contributing to cardiovascular disease and cancer...
  3. doi request reprint Prostaglandin E(2) primes the angiogenic switch via a synergic interaction with the fibroblast growth factor-2 pathway
    Federica Finetti
    Department of Molecular Biology, University of Siena, and Istituto Toscano Tumori, Italy
    Circ Res 105:657-66. 2009
    ..Prostaglandin (PG)E(2) exerts temporally distinct actions on blood vessels, immediate vasodilatation, and long-term activation of angiogenesis...
  4. pmc PKCε activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting
    Martina Monti
    Department of Life Sciences, University of Siena, 53100 Siena, Italy
    J Mol Cell Cardiol 63:107-17. 2013
    ..The results demonstrate that PKCε stimulation promotes angiogenesis and modulates VEGF activity, by inducing FGF-2 release and autocrine signaling. ..
  5. ncbi request reprint Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1
    Federica Finetti
    Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy
    J Biol Chem 283:2139-46. 2008
    ..This signaling pattern is similar to the autocrine-paracrine mechanism which operates in endothelial cells to support neovascular growth...
  6. doi request reprint Sulfhydryl angiotensin-converting enzyme inhibitor promotes endothelial cell survival through nitric-oxide synthase, fibroblast growth factor-2, and telomerase cross-talk
    Sandra Donnini
    Section of Pharmacology, Department of Molecular Biology, University of Siena, Via A Moro 2, 53100 Siena, Italy
    J Pharmacol Exp Ther 332:776-84. 2010
    ..These effects could explain the beneficial effects of these drugs in various cardiovascular diseases associated with endothelial injury and aging...
  7. pmc Pharmacological inhibition of microsomal prostaglandin E synthase-1 suppresses epidermal growth factor receptor-mediated tumor growth and angiogenesis
    Federica Finetti
    Department of Biotechnology, University of Siena, Via Aldo Moro, 2, Siena, and Istituto Toscano Tumori ITT, Italy
    PLoS ONE 7:e40576. 2012
    ..PGE(2) promotes epithelial tumor progression via multiple signaling pathways including the epidermal growth factor receptor (EGFR) signaling pathway...
  8. ncbi request reprint Divergent effects of quercetin conjugates on angiogenesis
    Sandra Donnini
    Section of Pharmacology, Department of Molecular Medicine, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Br J Nutr 95:1016-23. 2006
    ..Q3G and Q3'S are the two major conjugates in plasma, but their ratio is dependent on several factors, so that inhibition or activation of angiogenesis could be subtly shifted as a result of metabolism in vivo...
  9. doi request reprint Inhibition of hypoxia inducible factor-1alpha by dihydroxyphenylethanol, a product from olive oil, blocks microsomal prostaglandin-E synthase-1/vascular endothelial growth factor expression and reduces tumor angiogenesis
    Erika Terzuoli
    Department of Molecular Biology, University of Siena, Siena, Italy
    Clin Cancer Res 16:4207-16. 2010
    ..2-(3,4-dihydroxyphenil)-ethanol (DPE), a polyphenol present in olive oil, has been found to attenuate the growth of colon cancer cells, an effect presumably related to its anti-inflammatory activity...
  10. ncbi request reprint Pyrazolo-pyrimidine-derived c-Src inhibitor reduces angiogenesis and survival of squamous carcinoma cells by suppressing vascular endothelial growth factor production and signaling
    Sandra Donnini
    Dipartimento di Biologia Molecolare, Universita degli Studi di Siena, Via Aldo Moro, 2, 53100, Siena, Italy
    Int J Cancer 120:995-1004. 2007
    ....
  11. ncbi request reprint Physiological levels of amyloid peptides stimulate the angiogenic response through FGF-2
    Silvia Cantara
    Pharmacology Section, Department of Molecular Biology, University of Siena, Siena, Italy
    FASEB J 18:1943-5. 2004
    ..The angiogenesis promoted by Abeta peptides via FGF-2 might have implications for understanding the initial stages of Alzheimer's disease and for the design of therapies targeting beta amyloid...
  12. doi request reprint Abeta peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesis
    Sandra Donnini
    Department of Molecular Biology, Via Aldo Moro 2, University of Siena, 53100 Siena, Italy
    FASEB J 24:2385-95. 2010
    ..Premature Abeta-induced senescence of the endothelium, producing progressive alterations of microvessel morphology and functions, may represent one of the underlying mechanisms for sporadic or heritable CAA...
  13. pmc Dutch and Arctic mutant peptides of beta amyloid(1-40) differentially affect the FGF-2 pathway in brain endothelium
    Raffaella Solito
    Department of Molecular Biology, University of Siena, Via A Moro 2, 53100, Siena, Italy
    Exp Cell Res 315:385-95. 2009
    ..The biological dissimilar effect of the mutant and WT peptides on cerebral EC cannot be assigned to a particular Abeta structure, suggesting that the toxic effect of the Abeta assemblies goes beyond mere multimerization...
  14. pmc Mitochondrial aldehyde dehydrogenase-2 activation prevents β-amyloid-induced endothelial cell dysfunction and restores angiogenesis
    Raffaella Solito
    Department of Biotechnology, University of Siena, 53100 Siena, Italy
    J Cell Sci 126:1952-61. 2013
    ..Thus, agents activating ALDH2 may reduce endothelial injuries including those occurring in cerebral amyloid angiopathy, preserving the angiogenic potential of the endothelium...
  15. pmc deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification
    Martina Monti
    Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100, Siena, Italy
    J Mol Cell Cardiol 48:746-56. 2010
    ..Since endothelial health ensures better tissue perfusion and oxygenation, treatment with a deltaPKC inhibitor and/or an varepsilonPKC activator in diseases of endothelial dysfunction should be considered...
  16. ncbi request reprint EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways
    Sandra Donnini
    Department of Molecular Biology, Pharmacology Angiogenesis Lab, University of Siena, Via Aldo Moro, 2, 53100, Siena, Italy
    FASEB J 21:2418-30. 2007
    ..Silencing of iNOS also impaired EGFR-induced ERK1/2 phosphorylation. These results indicate that iNOS/GC signaling is a downstream player in the control of EP2/EGFR-mediated tumor cell proliferation and invasion...
  17. ncbi request reprint Fibroblast growth factor-2 mediates Angiotensin-converting enzyme inhibitor-induced angiogenesis in coronary endothelium
    Sandra Donnini
    Pharmacology Section, Department of Molecular Biology, Via A Moro 2, 53100 Siena, Italy
    J Pharmacol Exp Ther 319:515-22. 2006
    ..In conclusion, we show that ACEI exert protective/proangiogenic effects in microvascular coronary endothelial cells by activating the endogenous FGF-2/FGFR-1 system...
  18. ncbi request reprint Development of new drugs in angiogenesis
    Marina Ziche
    Lab of Pharmacology, Toxicology and Chemotherapy, Department of Molecular Biology, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Curr Drug Targets 5:485-93. 2004
    ..The status of pro- and anti-angiogenic therapies is here presented and discussed...
  19. ncbi request reprint ERK1-2 and p38 MAPK regulate MMP/TIMP balance and function in response to thrombospondin-1 fragments in the microvascular endothelium
    Sandra Donnini
    Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy
    Life Sci 74:2975-85. 2004
    ..This evidence indicates that fragments originating from TSP-1 switch the pro- or anti-angiogenic phenotype in endothelium by targeting MAPK cascades with opposite functions on MMP/TIMP balance...
  20. ncbi request reprint Angiosuppressive and angiostimulatory effects exerted by synthetic partial sequences of endostatin
    Lucia Morbidelli
    Pharmacology Section, Department of Molecular Biology, University of Siena, Siena, Italy
    Clin Cancer Res 9:5358-69. 2003
    ....
  21. doi request reprint Assessing vascular senescence in zebrafish
    Sandra Donnini
    Department of Biotechnology, University of Siena, Siena, Italy
    Methods Mol Biol 965:517-31. 2013
    ..This chapter describes the methods for studying cell senescence in zebrafish, detailing protocols for β-gal activity and the in situ p21 hybridization in whole-mount zebrafish embryos...
  22. doi request reprint RNA-mediated gene silencing of FUT1 and FUT2 influences expression and activities of bovine and human fucosylated nucleolin and inhibits cell adhesion and proliferation
    Domenico Palumberi
    Laboratory of Cell Biology and Glycobiology, Department of Evolutionary Biology, University of Siena, Siena, Italy
    J Cell Biochem 111:229-38. 2010
    ..A reduced expression of fucosylated nucleolin and inhibition of cell growth by suppressing FUT1/2 expression was also tested and shown to be exhibited in human A431 cells...
  23. pmc Antagonism of Bradykinin B2 Receptor Prevents Inflammatory Responses in Human Endothelial Cells by Quenching the NF-kB Pathway Activation
    Erika Terzuoli
    Department of Life Sciences, University of Siena, Siena, Italy
    PLoS ONE 9:e84358. 2014
    ..Bradykinin (BK) induces angiogenesis by promoting vessel permeability, growth and remodeling. This study aimed to demonstrate that the B2R antagonist, fasitibant, inhibits the BK pro-angiogenic effects...
  24. doi request reprint A novel protein from the serum of Python sebae, structurally homologous with type-γ phospholipase A(2) inhibitor, displays antitumour activity
    Sandra Donnini
    Department of Biotechnology and Istituto Toscano Tumori, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Biochem J 440:251-62. 2011
    ....
  25. doi request reprint Hydrogen peroxide mediates endothelium-dependent dilation of coronary arterioles in obese rats on a low-carbohydrate diet
    Marta Focardi
    Department of Cardiovascular Disease, University of Siena, Siena, Italy
    Microcirculation 20:599-608. 2013
    ..Endothelium-dependent vasodilation of coronary arterioles is impaired in obese rats and may be improved by a LCD. The aim of this study is to elucidate the mechanism by which this improvement occurs...
  26. ncbi request reprint Constitutive and inducible nitric oxide synthase: role in angiogenesis
    Sandra Donnini
    Institute of Pharmacological Sciences, University of Siena, 53100, Italy
    Antioxid Redox Signal 4:817-23. 2002
    ..The dual personality of NO will be reviewed in the context of the angiogenesis process...
  27. ncbi request reprint Effect of hypoxia and endothelial loss on vascular smooth muscle cell responsiveness to VEGF-A: role of flt-1/VEGF-receptor-1
    Astrid Parenti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, Italy
    Cardiovasc Res 55:201-12. 2002
    ..The influence of hypoxia and endothelial loss on the responsiveness of vascular smooth muscle cells (VSMCs) to vascular endothelial growth factor (VEGF-A) was tested...
  28. doi request reprint Nitric oxide releasing metal-diazeniumdiolate complexes strongly induce vasorelaxation and endothelial cell proliferation
    Marina Ziche
    Sezione di Farmacologia, Dipartimento di Biologia Molecolare, Universita di Siena, Via Aldo Moro 2, 53100 Siena, Italy
    ChemMedChem 3:1039-47. 2008
    ..In all biological assays, the reference agent sodium nitroprusside was shown to be 10-1000-fold less potent than the two metal-NONOates...
  29. ncbi request reprint Role of nitric oxide in tumor angiogenesis
    Lucia Morbidelli
    Section of Pharmacology, Dept Molecular Biology and C R I S M A, University of Siena Pharmacy School, Via A Moro 2, 53100 Siena, Italy
    Cancer Treat Res 117:155-67. 2004
    ..Drugs affecting the NOS pathway appear promising antitumor strategies by reducing edema, inhibiting angiogenesis and facilitating the delivery of chemotherapeutical agents...
  30. ncbi request reprint Role of nitric oxide in the modulation of angiogenesis
    Lucia Morbidelli
    Institute of Pharmacological Sciences and CRISMA, University of Siena Pharmacy School, Via A Moro 2, 53100 Siena, Italy
    Curr Pharm Des 9:521-30. 2003
    ..In particular, the use of NOS inhibitors or NO scavengers seems appropriate to reduce edema, block angiogenesis and facilitate antitumor drug delivery...