Research Topics
Genomes and Genes | Sandra DonniniSummaryAffiliation: University of Siena Country: Italy Publications
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Publications
Peroxynitrite inactivates human-tissue inhibitor of metalloproteinase-4Sandra Donnini
Departments of Molecular Biology, University of Siena, Via A Moro, 2, Siena 53100, Italy
FEBS Lett 582:1135-40. 2008..HPLC/ESI-MS/MS analysis of peroxynitrite-treated TIMP-4 showed modifications at Y114, Y195, Y188 and Y190. In conclusion, TIMP-4 nitration might be a potential mechanism contributing to cardiovascular disease and cancer...
Prevention of ischemic brain injury by treatment with the membrane penetrating apoptosis inhibitor, TAT-BH4Sandra Donnini
Department of Molecular Biology, University of Siena, via Moro 2, Siena, Italy
Cell Cycle 8:1271-8. 2009..These findings indicate that TAT-BH4 administration protects against acute hypoxia/ischemia injury in the brain by preventing endothelial and neuron cell apoptosis and by inducing neuronal plasticity...- Prostaglandin E(2) primes the angiogenic switch via a synergic interaction with the fibroblast growth factor-2 pathwayFederica Finetti
Department of Molecular Biology, University of Siena, and Istituto Toscano Tumori, Italy
Circ Res 105:657-66. 2009..Prostaglandin (PG)E(2) exerts temporally distinct actions on blood vessels, immediate vasodilatation, and long-term activation of angiogenesis... - Prostaglandin E2 regulates angiogenesis via activation of fibroblast growth factor receptor-1Federica Finetti
Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy
J Biol Chem 283:2139-46. 2008..This signaling pattern is similar to the autocrine-paracrine mechanism which operates in endothelial cells to support neovascular growth... - Sulfhydryl angiotensin-converting enzyme inhibitor promotes endothelial cell survival through nitric-oxide synthase, fibroblast growth factor-2, and telomerase cross-talkSandra Donnini
Section of Pharmacology, Department of Molecular Biology, University of Siena, Via A Moro 2, 53100 Siena, Italy
J Pharmacol Exp Ther 332:776-84. 2010..These effects could explain the beneficial effects of these drugs in various cardiovascular diseases associated with endothelial injury and aging... 
Pharmacological inhibition of microsomal prostaglandin E synthase-1 suppresses epidermal growth factor receptor-mediated tumor growth and angiogenesisFederica Finetti
Department of Biotechnology, University of Siena, Via Aldo Moro, 2, Siena, and Istituto Toscano Tumori ITT, Italy
PLoS ONE 7:e40576. 2012..PGE(2) promotes epithelial tumor progression via multiple signaling pathways including the epidermal growth factor receptor (EGFR) signaling pathway...- Inhibition of hypoxia inducible factor-1alpha by dihydroxyphenylethanol, a product from olive oil, blocks microsomal prostaglandin-E synthase-1/vascular endothelial growth factor expression and reduces tumor angiogenesisErika Terzuoli
Department of Molecular Biology, University of Siena, Siena, Italy
Clin Cancer Res 16:4207-16. 2010..2-(3,4-dihydroxyphenil)-ethanol (DPE), a polyphenol present in olive oil, has been found to attenuate the growth of colon cancer cells, an effect presumably related to its anti-inflammatory activity... - Divergent effects of quercetin conjugates on angiogenesisSandra Donnini
Section of Pharmacology, Department of Molecular Medicine, University of Siena, Via A. Moro 2, 53100 Siena, Italy
Br J Nutr 95:1016-23. 2006..Q3G and Q3'S are the two major conjugates in plasma, but their ratio is dependent on several factors, so that inhibition or activation of angiogenesis could be subtly shifted as a result of metabolism in vivo... - Pyrazolo-pyrimidine-derived c-Src inhibitor reduces angiogenesis and survival of squamous carcinoma cells by suppressing vascular endothelial growth factor production and signalingSandra Donnini
Dipartimento di Biologia Molecolare, Universita degli Studi di Siena, Via Aldo Moro, 2, 53100, Siena, Italy
Int J Cancer 120:995-1004. 2007.... - Physiological levels of amyloid peptides stimulate the angiogenic response through FGF-2Silvia Cantara
Pharmacology Section, Department of Molecular Biology, University of Siena, Siena, Italy
FASEB J 18:1943-5. 2004..The angiogenesis promoted by Abeta peptides via FGF-2 might have implications for understanding the initial stages of Alzheimer's disease and for the design of therapies targeting beta amyloid... - Abeta peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesisSandra Donnini
Department of Molecular Biology, Via Aldo Moro 2, University of Siena, 53100 Siena, Italy
FASEB J 24:2385-95. 2010..Premature Abeta-induced senescence of the endothelium, producing progressive alterations of microvessel morphology and functions, may represent one of the underlying mechanisms for sporadic or heritable CAA... - Dutch and Arctic mutant peptides of beta amyloid(1-40) differentially affect the FGF-2 pathway in brain endotheliumRaffaella Solito
Department of Molecular Biology, University of Siena, Via A Moro 2, 53100, Siena, Italy
Exp Cell Res 315:385-95. 2009..The biological dissimilar effect of the mutant and WT peptides on cerebral EC cannot be assigned to a particular Abeta structure, suggesting that the toxic effect of the Abeta assemblies goes beyond mere multimerization... - Fibroblast growth factor-2 mediates Angiotensin-converting enzyme inhibitor-induced angiogenesis in coronary endotheliumSandra Donnini
Pharmacology Section, Department of Molecular Biology, Via A. Moro 2, 53100 Siena, Italy
J Pharmacol Exp Ther 319:515-22. 2006..In conclusion, we show that ACEI exert protective/proangiogenic effects in microvascular coronary endothelial cells by activating the endogenous FGF-2/FGFR-1 system... - EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathwaysSandra Donnini
Department of Molecular Biology, Pharmacology Angiogenesis Lab, University of Siena, Via Aldo Moro, 2, 53100, Siena, Italy
FASEB J 21:2418-30. 2007..Silencing of iNOS also impaired EGFR-induced ERK1/2 phosphorylation. These results indicate that iNOS/GC signaling is a downstream player in the control of EP2/EGFR-mediated tumor cell proliferation and invasion... - deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modificationMartina Monti
Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100, Siena, Italy
J Mol Cell Cardiol 48:746-56. 2010..Since endothelial health ensures better tissue perfusion and oxygenation, treatment with a deltaPKC inhibitor and/or an varepsilonPKC activator in diseases of endothelial dysfunction should be considered... - Development of new drugs in angiogenesisMarina Ziche
Lab of Pharmacology, Toxicology and Chemotherapy, Department of Molecular Biology, University of Siena, Via A Moro 2, 53100 Siena, Italy
Curr Drug Targets 5:485-93. 2004..The status of pro- and anti-angiogenic therapies is here presented and discussed... - Angiosuppressive and angiostimulatory effects exerted by synthetic partial sequences of endostatinLucia Morbidelli
Pharmacology Section, Department of Molecular Biology, University of Siena, Siena, Italy
Clin Cancer Res 9:5358-69. 2003..CONCLUSIONS: In view of these results, which show strikingly distinct profiles of endostatin fragments, we propose that the amino acid sequence of endostatin contains both angiosuppressive and angiostimulatory domains... - ERK1-2 and p38 MAPK regulate MMP/TIMP balance and function in response to thrombospondin-1 fragments in the microvascular endotheliumSandra Donnini
Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy
Life Sci 74:2975-85. 2004..This evidence indicates that fragments originating from TSP-1 switch the pro- or anti-angiogenic phenotype in endothelium by targeting MAPK cascades with opposite functions on MMP/TIMP balance... - RNA-mediated gene silencing of FUT1 and FUT2 influences expression and activities of bovine and human fucosylated nucleolin and inhibits cell adhesion and proliferationDomenico Palumberi
Laboratory of Cell Biology and Glycobiology, Department of Evolutionary Biology, University of Siena, Siena, Italy
J Cell Biochem 111:229-38. 2010..A reduced expression of fucosylated nucleolin and inhibition of cell growth by suppressing FUT1/2 expression was also tested and shown to be exhibited in human A431 cells... - A novel protein from the serum of Python sebae, structurally homologous with type-γ phospholipase A(2) inhibitor, displays antitumour activitySandra Donnini
Department of Biotechnology and Istituto Toscano Tumori, University of Siena, Via A Moro 2, 53100 Siena, Italy
Biochem J 440:251-62. 2011.... - Assessing vascular senescence in zebrafishSandra Donnini
Department of Biotechnology, University of Siena, Siena, Italy
Methods Mol Biol 965:517-31. 2013..This chapter describes the methods for studying cell senescence in zebrafish, detailing protocols for β-gal activity and the in situ p21 hybridization in whole-mount zebrafish embryos... - Constitutive and inducible nitric oxide synthase: role in angiogenesisSandra Donnini
Institute of Pharmacological Sciences, University of Siena, 53100, Italy
Antioxid Redox Signal 4:817-23. 2002..The dual personality of NO will be reviewed in the context of the angiogenesis process... - Effect of hypoxia and endothelial loss on vascular smooth muscle cell responsiveness to VEGF-A: role of flt-1/VEGF-receptor-1Astrid Parenti
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, Italy
Cardiovasc Res 55:201-12. 2002..The influence of hypoxia and endothelial loss on the responsiveness of vascular smooth muscle cells (VSMCs) to vascular endothelial growth factor (VEGF-A) was tested... - Nitric oxide releasing metal-diazeniumdiolate complexes strongly induce vasorelaxation and endothelial cell proliferationMarina Ziche
Sezione di Farmacologia, Dipartimento di Biologia Molecolare, Universita di Siena, Via Aldo Moro 2, 53100 Siena, Italy
ChemMedChem 3:1039-47. 2008..In all biological assays, the reference agent sodium nitroprusside was shown to be 10-1000-fold less potent than the two metal-NONOates... - Role of nitric oxide in tumor angiogenesisLucia Morbidelli
Section of Pharmacology, Dept. Molecular Biology and C.R.I.S.M.A, University of Siena Pharmacy School, Via A. Moro 2, 53100 Siena, Italy
Cancer Treat Res 117:155-67. 2004..Drugs affecting the NOS pathway appear promising antitumor strategies by reducing edema, inhibiting angiogenesis and facilitating the delivery of chemotherapeutical agents... - Role of nitric oxide in the modulation of angiogenesisLucia Morbidelli
Institute of Pharmacological Sciences and CRISMA, University of Siena Pharmacy School, Via A Moro 2, 53100 Siena, Italy
Curr Pharm Des 9:521-30. 2003..In particular, the use of NOS inhibitors or NO scavengers seems appropriate to reduce edema, block angiogenesis and facilitate antitumor drug delivery...