Rosario Donato

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. pmc S100B inhibits myogenic differentiation and myotube formation in a RAGE-independent manner
    Guglielmo Sorci
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy
    Mol Cell Biol 23:4870-81. 2003
  2. pmc Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE binding
    Guglielmo Sorci
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    Mol Cell Biol 24:4880-94. 2004
  3. ncbi request reprint S100B increases proliferation in PC12 neuronal cells and reduces their responsiveness to nerve growth factor via Akt activation
    Cataldo Arcuri
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy
    J Biol Chem 280:4402-14. 2005
  4. ncbi request reprint The amphoterin (HMGB1)/receptor for advanced glycation end products (RAGE) pair modulates myoblast proliferation, apoptosis, adhesiveness, migration, and invasiveness. Functional inactivation of RAGE in L6 myoblasts results in tumor formation in vivo
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Casella Postale 81 Succursale 3, 06122 Perugia, Italy
    J Biol Chem 281:8242-53. 2006
  5. ncbi request reprint S100B stimulates myoblast proliferation and inhibits myoblast differentiation by independently stimulating ERK1/2 and inhibiting p38 MAPK
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Cell Physiol 207:461-70. 2006
  6. pmc Functions of S100 proteins
    R Donato
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Curr Mol Med 13:24-57. 2013
  7. pmc RAGE expression in rhabdomyosarcoma cells results in myogenic differentiation and reduced proliferation, migration, invasiveness, and tumor growth
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    Am J Pathol 171:947-61. 2007
  8. doi request reprint S100B's double life: intracellular regulator and extracellular signal
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, Section Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    Biochim Biophys Acta 1793:1008-22. 2009
  9. ncbi request reprint RAGE: a single receptor for several ligands and different cellular responses: the case of certain S100 proteins
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Curr Mol Med 7:711-24. 2007
  10. ncbi request reprint Intracellular and extracellular roles of S100 proteins
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, 06122 Perugia, Italy
    Microsc Res Tech 60:540-51. 2003

Collaborators

Detail Information

Publications49

  1. pmc S100B inhibits myogenic differentiation and myotube formation in a RAGE-independent manner
    Guglielmo Sorci
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy
    Mol Cell Biol 23:4870-81. 2003
    ..Our data suggest that S100B might participate in the regulation of muscle development and regeneration by inhibiting crucial steps of the myogenic program in a RAGE-independent manner...
  2. pmc Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE binding
    Guglielmo Sorci
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    Mol Cell Biol 24:4880-94. 2004
    ..These data suggest that RAGE and amphoterin might play an important role in myogenesis, accelerating myogenic differentiation via Cdc42-Rac-1-MAPK kinase 6-p38 MAPK...
  3. ncbi request reprint S100B increases proliferation in PC12 neuronal cells and reduces their responsiveness to nerve growth factor via Akt activation
    Cataldo Arcuri
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy
    J Biol Chem 280:4402-14. 2005
    ..Thus, S100B might promote cell proliferation and interfere with NGF-induced PC12 cell differentiation by stimulating a p21WAF1/cyclin D1/cdk4/Rb/E2F pathway in an Akt-mediated manner...
  4. ncbi request reprint The amphoterin (HMGB1)/receptor for advanced glycation end products (RAGE) pair modulates myoblast proliferation, apoptosis, adhesiveness, migration, and invasiveness. Functional inactivation of RAGE in L6 myoblasts results in tumor formation in vivo
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Casella Postale 81 Succursale 3, 06122 Perugia, Italy
    J Biol Chem 281:8242-53. 2006
    ....
  5. ncbi request reprint S100B stimulates myoblast proliferation and inhibits myoblast differentiation by independently stimulating ERK1/2 and inhibiting p38 MAPK
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Cell Physiol 207:461-70. 2006
    ..We propose that S100B might participate in the regulation of myoblast differentiation by stimulating myoblast proliferation, protecting myoblasts against apoptosis, and modulating myotube formation...
  6. pmc Functions of S100 proteins
    R Donato
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Curr Mol Med 13:24-57. 2013
    ....
  7. pmc RAGE expression in rhabdomyosarcoma cells results in myogenic differentiation and reduced proliferation, migration, invasiveness, and tumor growth
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    Am J Pathol 171:947-61. 2007
    ..These data suggest that deregulation of RAGE expression in myoblasts might concur in rhabdomyosarcomagenesis and that increasing RAGE expression in rhabdomyosarcoma cells might reduce their tumor potential...
  8. doi request reprint S100B's double life: intracellular regulator and extracellular signal
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, Section Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    Biochim Biophys Acta 1793:1008-22. 2009
    ..Future studies using S100B transgenic and S100B null mice might shed more light on the functional role(s) of the protein...
  9. ncbi request reprint RAGE: a single receptor for several ligands and different cellular responses: the case of certain S100 proteins
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Curr Mol Med 7:711-24. 2007
    ..Thus, S100/RAGE interactions might have important consequences during development and in tissue homeostasis as well as in inflammatory, degenerative and tumor processes...
  10. ncbi request reprint Intracellular and extracellular roles of S100 proteins
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, 06122 Perugia, Italy
    Microsc Res Tech 60:540-51. 2003
    ..Collectively, these data indicate that members of the S100 protein family are multifunctional proteins implicated in the regulation of a variety of cellular activities...
  11. ncbi request reprint S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles
    R Donato
    Department of Experimental and Biochemical Sciences, Section of Anatomy, University of Perugia, Via del Giochetto, C P 81 Succ 3, 06122, Perugia, Italy
    Int J Biochem Cell Biol 33:637-68. 2001
    ..Future analyses should discriminate between functionally relevant S100 interactions with target proteins and in vitro observations devoid of physiological importance...
  12. ncbi request reprint Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type
    R Donato
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, C P 81 Succ 3, 06122, Perugia, Italy
    Biochim Biophys Acta 1450:191-231. 1999
    ....
  13. ncbi request reprint S100B binding to RAGE in microglia stimulates COX-2 expression
    Roberta Bianchi
    Department of Experimental Medicine and Biochemical Sciences, Sect Anatomy, University of Perugia, Via del Giochetto C P 81 Succ 3, 06122 Perugia, Italy
    J Leukoc Biol 81:108-18. 2007
    ..Thus, S100B can be viewed as an astrocytic endokine, which might participate in the inflammatory response in the course of brain insults, once liberated into the brain extracellular space...
  14. pmc S100B engages RAGE or bFGF/FGFR1 in myoblasts depending on its own concentration and myoblast density. Implications for muscle regeneration
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences and Istituto Interuniversitario di Miologia, University of Perugia, Perugia, Italy
    PLoS ONE 7:e28700. 2012
    ....
  15. doi request reprint S100B protein in myoblasts modulates myogenic differentiation via NF-kappaB-dependent inhibition of MyoD expression
    Claudia Tubaro
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Cell Physiol 223:270-82. 2010
    ..Thus, intracellular S100B might modulate myoblast differentiation by interfering with MyoD expression in an NF-kappaB-dependent manner...
  16. pmc Glucocorticoid-induced leucine zipper (GILZ) and long GILZ inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids
    Stefano Bruscoli
    Dipartimento di Medicina Clinica e Sperimentale, Sezione di Farmacologia, Tossicologia e Chemioterapia, Universita di Perugia, 06122 Perugia, Italy
    J Biol Chem 285:10385-96. 2010
    ..Notably, results indicate that GILZ and L-GILZ bind and regulate MyoD/HDAC1 transcriptional activity, thus mediating the anti-myogenic effect of GCs...
  17. pmc S100B protein stimulates microglia migration via RAGE-dependent up-regulation of chemokine expression and release
    Roberta Bianchi
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, 06122 Perugia, Italy
    J Biol Chem 286:7214-26. 2011
    ..These results suggests that S100B might participate in the pathophysiology of brain inflammatory disorders via RAGE-dependent regulation of several inflammation-related events including activation and migration of microglia...
  18. ncbi request reprint The many faces of S100B protein: when an extracellular factor inactivates its own receptor and activates another one
    Guglielmo Sorci
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia
    Ital J Anat Embryol 115:147-51. 2010
    ..However, recent evidence suggests that S100B might also activate basic fibroblast growth factor receptor 1 via prior binding to basic fibroblast growth factor...
  19. doi request reprint S100B in myoblasts regulates the transition from activation to quiescence and from quiescence to activation and reduces apoptosis
    Claudia Tubaro
    Department of Experimental Medicine and Biochemical Sciences and Istituto Interuniversitario di Miologia, University of Perugia, Via del Glochetto, 06122 Perugia, Italy
    Biochim Biophys Acta 1813:1092-104. 2011
    ..This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  20. doi request reprint S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences and Istituto Interuniversitario di Miologia, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    J Cell Sci 124:2389-400. 2011
    ..These results reveal a new S100B-interacting protein - bFGF - in the extracellular milieu and suggest that S100B stimulates myoblast proliferation and inhibits myogenic differentiation by activating FGFR1 in a bFGF-dependent manner...
  21. doi request reprint S100B/RAGE-dependent activation of microglia via NF-kappaB and AP-1 Co-regulation of COX-2 expression by S100B, IL-1beta and TNF-alpha
    Roberta Bianchi
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, C P 81 Succ 3, 06122 Perugia, Italy
    Neurobiol Aging 31:665-77. 2010
    ..Given the crucial roles of COX-2, IL-1beta and TNF-alpha in the inflammatory response, we propose that, by engaging RAGE, S100B might play an important role in microglia activation in the course of brain damage...
  22. pmc Human muscle satellite cells show age-related differential expression of S100B protein and RAGE
    Sara Beccafico
    Department of Experimental Medicine and Biochemical Sciences, IIM, University of Perugia, Italy
    Age (Dordr) 33:523-41. 2011
    ..g., bFGF and S100B), they were no longer able to secrete these factors, unlike young SCs. These data support a role for intrinsic factors, besides the extracellular environment in the defective SC function in aged skeletal muscles...
  23. pmc S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH
    Flora Brozzi
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, C P 81 Succ 3, 06122 Perugia, Italy
    J Biol Chem 284:8797-811. 2009
    ....
  24. ncbi request reprint S100B causes apoptosis in a myoblast cell line in a RAGE-independent manner
    Guglielmo Sorci
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, Perugia, Italy
    J Cell Physiol 199:274-83. 2004
    ..Our data also suggest that RAGE has no role in the transduction of S100B effects on myoblasts, implying that S100B can interact with more than one receptor to affect its target cells...
  25. doi request reprint HMGB1-RAGE regulates muscle satellite cell homeostasis through p38-MAPK- and myogenin-dependent repression of Pax7 transcription
    Francesca Riuzzi
    Department of Experimental Medicine and Biochemical Sciences and Istituto Interuniversitario di Miologia, University of Perugia, Via del Giochetto, 06122, Perugia, Italy
    J Cell Sci 125:1440-54. 2012
    ..Thus, RAGE signaling physiologically repressed Pax7 transcription in SCs by upregulating myogenin, thereby accelerating muscle regeneration and limiting SC self-renewal...
  26. pmc Genetically-determined hyperfunction of the S100B/RAGE axis is a risk factor for aspergillosis in stem cell transplant recipients
    Cristina Cunha
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    PLoS ONE 6:e27962. 2011
    ....
  27. ncbi request reprint Subcellular localization of S100A11 (S100C) in LLC-PK1 renal cells: Calcium- and protein kinase c-dependent association of S100A11 with S100B and vimentin intermediate filaments
    Roberta Bianchi
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, 06122 Perugia, Italy
    Microsc Res Tech 60:639-51. 2003
    ....
  28. pmc The danger signal S100B integrates pathogen- and danger-sensing pathways to restrain inflammation
    Guglielmo Sorci
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    PLoS Pathog 7:e1001315. 2011
    ....
  29. doi request reprint RAGE in tissue homeostasis, repair and regeneration
    Guglielmo Sorci
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Biochim Biophys Acta 1833:101-9. 2013
    ..RAGE effects are strongly dependent on the cell type and the context, which may condition therapeutic strategies aimed at reducing RAGE signaling...
  30. pmc S100B protein in tissue development, repair and regeneration
    Guglielmo Sorci
    Guglielmo Sorci, Francesca Riuzzi, Cataldo Arcuri, Claudia Tubaro, Roberta Bianchi, Ileana Giambanco, Rosario Donato, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy
    World J Biol Chem 4:1-12. 2013
    ..The present commentary summarizes results implicating intracellular and extracellular S100B in tissue development, repair and regeneration...
  31. ncbi request reprint S100B-stimulated NO production by BV-2 microglia is independent of RAGE transducing activity but dependent on RAGE extracellular domain
    Cecilia Adami
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, C P 81 Succ 3, 06122 Perugia, Italy
    Biochim Biophys Acta 1742:169-77. 2004
    ....
  32. ncbi request reprint Annexin V, annexin VI, S100A1 and S100B in developing and adult avian skeletal muscles
    C Arcuri
    Department of Experimental Medicine and Biochemical Sciences, Section of Anatomy, University of Perugia, Via del Giochetto, C P 81 Succ 3, 06122 Perugia, Italy
    Neuroscience 109:371-88. 2002
    ....
  33. ncbi request reprint Subcellular localization of S100A11 (S100C, calgizzarin) in developing and adult avian skeletal muscles
    Cataldo Arcuri
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, C P 81 Succ 3, 06122, Perugia, Italy
    Biochim Biophys Acta 1600:84-94. 2002
    ..Our data suggests that, like S100A1 and S100B, S100A11 might have a role in the regulation of membrane activities, probably in relation to Ca(2+) fluxes in skeletal muscle cells...
  34. ncbi request reprint Prosaposin is immunolocalized to muscle and prosaptides promote myoblast fusion and attenuate loss of muscle mass after nerve injury
    M Rende
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia School of Medicine, Via del Giochetto, 06122 Perugia, Italy
    Muscle Nerve 24:799-808. 2001
    ..These data suggest that, in addition to neurotrophic and myelinotrophic activities, prosaposin has myotrophic properties...
  35. ncbi request reprint Nerve growth factor (NGF) influences differentiation and proliferation of myogenic cells in vitro via TrKA
    M Rende
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia School of Medicine, Italy
    Int J Dev Neurosci 18:869-85. 2000
    ....
  36. ncbi request reprint Rat brain cortex mitochondria release group II secretory phospholipase A(2) under reduced membrane potential
    Lara Macchioni
    Department of Internal Medicine, Division of Biochemistry, University of Perugia, I 06125 Perugia, Italy
    J Biol Chem 279:37860-9. 2004
    ..We hypothesize that, under reduced respiratory rate, brain mitochondria release sPLA(2)-IIA that might contribute to cell damage...
  37. ncbi request reprint The calcium-modulated proteins, S100A1 and S100B, as potential regulators of the dynamics of type III intermediate filaments
    M Garbuglia
    Section of Anatomy, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Braz J Med Biol Res 32:1177-85. 1999
    ....
  38. ncbi request reprint Annexin VI binds S100A1 and S100B and blocks the ability of S100A1 and S100B to inhibit desmin and GFAP assemblies into intermediate filaments
    M Garbuglia
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Cell Calcium 24:177-91. 1998
    ..The present data suggest that annexin VI might regulate S100A1 and S100B activities and vice versa...
  39. pmc Role of CD45 signaling pathway in galactoxylomannan-induced T cell damage
    Eva Pericolini
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    PLoS ONE 5:e12720. 2010
    ..Overall this mechanism may be responsible for the immune paralysis that follows GalXM administration and could explain the powerful immunosuppression that accompanies cryptococcosis...
  40. ncbi request reprint Detection of membrane-bound guanylate cyclase activity in rat C6 glioma cells at different growth states following activation by natriuretic peptides
    G Sorci
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Brain Res 683:51-8. 1995
    ..These data suggest that GC is differentially located depending on the state of growth of glial cells, and that in differentiating glial cells GC is preferentially located in cell processes...
  41. ncbi request reprint Immunocytochemical analyses of annexin V (CaBP33) in a human-derived glioma cell line. Expression of annexin V depends on cellular growth state
    I Giambanco
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    FEBS Lett 323:45-50. 1993
    ....
  42. ncbi request reprint Ultracytochemistry as a tool for the study of the cellular and subcellular localization of membrane-bound guanylate cyclase (GC) activity. Applicability to both receptor-activated and receptor-independent GC activity
    Maria Grazia Rambotti
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Mol Cell Biochem 230:85-96. 2002
    ..The results of these analyses are discussed in relation to the proposed functional role(s) of this enzyme...
  43. ncbi request reprint 'Neuron-specific' protein gene product 9.5 (PGP 9.5) is also expressed in glioma cell lines and its expression depends on cellular growth state
    I Giambanco
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    FEBS Lett 290:131-4. 1991
    ..5 in cultured glial cells is maximally expressed during the growth phase and that the protein could play a role during brain development in glial cells, in reactive gliosis, or in tumorigenesis of the glial lineage...
  44. ncbi request reprint Effects of calcium-binding proteins (S-100a(o), S-100a, S-100b) on desmin assembly in vitro
    M Garbuglia
    Department of Experimental Medicine, University of Perugia, Italy
    FASEB J 10:317-24. 1996
    ..The present data suggest that S-100a(o) might play a role in the regulation of the state of assembly of desmin intermediate filaments...
  45. ncbi request reprint S100A1 codistributes with synapsin I in discrete brain areas and inhibits the F-actin-bundling activity of synapsin I
    Fabio Benfenati
    Department of Experimental Medicine, Section of Human Physiology, University of Genoa, Viale Benedetto XV, 16132 Genoa, Italy
    J Neurochem 89:1260-70. 2004
    ....
  46. ncbi request reprint Involvement of the S100B in cAMP-induced cytoskeleton remodeling in astrocytes: a study using TRTK-12 in digitonin-permeabilized cells
    Juliana K Frizzo
    Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Cell Mol Neurobiol 24:833-40. 2004
    ..4. TRTK-12 was able to block cAMP-induced astrocyte stellation and this effect was dependent on the concentration of the peptide. These results support the idea that S100B has a modulatory role on astrocyte morphology...
  47. ncbi request reprint S100B-mediated inhibition of the phosphorylation of GFAP is prevented by TRTK-12
    Juliana Karl Frizzo
    Departamento de Bioquimica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Neurochem Res 29:735-40. 2004
    ..These data suggest a role for S100B in the assembly of intermediate filaments in astrocytes...
  48. ncbi request reprint Distinct signaling pathways for induction of type II NOS by IFNgamma and LPS in BV-2 microglial cells
    Siming Shen
    Department of Nutritional Sciences, University of Missouri, Columbia, MO 65212, USA
    Neurochem Int 47:298-307. 2005
    ..These results demonstrated distinct signaling pathways for induction of iNOS by IFNgamma and LPS in BV-2 microglial cells...
  49. ncbi request reprint S100b counteracts effects of the neurotoxicant trimethyltin on astrocytes and microglia
    Camilla Reali
    Department of Cytomorphology, University of Cagliari, Monserrato, Italy
    J Neurosci Res 81:677-86. 2005
    ..These results might help in understanding the role played by glial cells in brain injury after exposure to chemical neurotoxicants and support the view that S100B may protect brain cells in case of injury. (c) 2005 Wiley-Liss, Inc...