F Dieli

Summary

Affiliation: University of Palermo
Country: Italy

Publications

  1. ncbi request reprint Identification of epitopes of Mycobacterium tuberculosis 16-kDa protein recognized by human leukocyte antigen-A*0201 CD8(+) T lymphocytes
    Nadia Caccamo
    Department of Biopathology, University of Palermo, Palermo, Italy
    J Infect Dis 186:991-8. 2002
  2. pmc New tools for detecting latent tuberculosis infection: evaluation of RD1-specific long-term response
    Ornella Butera
    Department of Epidemiology and Preclinical Research, L Spallanzani National institute for infectious diseases, IRCCS, Rome, Italy
    BMC Infect Dis 9:182. 2009
  3. pmc Differentiation of effector/memory Vdelta2 T cells and migratory routes in lymph nodes or inflammatory sites
    Francesco Dieli
    Dept of Biopathology, University of Palermo, Italy
    J Exp Med 198:391-7. 2003
  4. ncbi request reprint Selective depression of interferon-gamma and granulysin production with increase of proliferative response by Vgamma9/Vdelta2 T cells in children with tuberculosis
    Francesco Dieli
    Dipartimento di Biopatologia, Universita di Palermo, 90134 Palermo, Italy
    J Infect Dis 186:1835-9. 2002
  5. ncbi request reprint An anti-inflammatory role for V alpha 14 NK T cells in Mycobacterium bovis bacillus Calmette-Guérin-infected mice
    Francesco Dieli
    Department of Biopathology, University of Palermo, Palermo, Italy
    J Immunol 171:1961-8. 2003
  6. ncbi request reprint Biology of gammadelta T cells in tuberculosis and malaria
    F Dieli
    Department of Biopathology, University of Palermo, Italy
    Curr Mol Med 1:437-46. 2001
  7. ncbi request reprint Characterization of lung gamma delta T cells following intranasal infection with Mycobacterium bovis bacillus Calmette-Guérin
    Francesco Dieli
    Department of Biopathology, University of Palermo, Palermo, Italy
    J Immunol 170:463-9. 2003
  8. ncbi request reprint Reciprocal stimulation of gammadelta T cells and dendritic cells during the anti-mycobacterial immune response
    Francesco Dieli
    Dipartimento di Biopatologia, Universita di Palermo, Palermo, Italy
    Eur J Immunol 34:3227-35. 2004
  9. ncbi request reprint Sequestration of T lymphocytes to body fluids in tuberculosis: reversal of anergy following chemotherapy
    F Dieli
    Institute of General Pathology, University of Palermo, 90134 Palermo, Italy
    J Infect Dis 180:225-8. 1999
  10. ncbi request reprint Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer
    Francesco Dieli
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Cancer Res 67:7450-7. 2007

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Identification of epitopes of Mycobacterium tuberculosis 16-kDa protein recognized by human leukocyte antigen-A*0201 CD8(+) T lymphocytes
    Nadia Caccamo
    Department of Biopathology, University of Palermo, Palermo, Italy
    J Infect Dis 186:991-8. 2002
    ..Our data suggest that these antigenic peptides can play a critical role in effective immunity against mycobacterial infection and TB...
  2. pmc New tools for detecting latent tuberculosis infection: evaluation of RD1-specific long-term response
    Ornella Butera
    Department of Epidemiology and Preclinical Research, L Spallanzani National institute for infectious diseases, IRCCS, Rome, Italy
    BMC Infect Dis 9:182. 2009
    ....
  3. pmc Differentiation of effector/memory Vdelta2 T cells and migratory routes in lymph nodes or inflammatory sites
    Francesco Dieli
    Dept of Biopathology, University of Palermo, Italy
    J Exp Med 198:391-7. 2003
    ....
  4. ncbi request reprint Selective depression of interferon-gamma and granulysin production with increase of proliferative response by Vgamma9/Vdelta2 T cells in children with tuberculosis
    Francesco Dieli
    Dipartimento di Biopatologia, Universita di Palermo, 90134 Palermo, Italy
    J Infect Dis 186:1835-9. 2002
    ..Disease-associated changes in Vgamma9/Vdelta2 T cell effector functions in patients with tuberculosis are consistent with the possibility that these T cells may play a protective role in immune response against M. tuberculosis infection...
  5. ncbi request reprint An anti-inflammatory role for V alpha 14 NK T cells in Mycobacterium bovis bacillus Calmette-Guérin-infected mice
    Francesco Dieli
    Department of Biopathology, University of Palermo, Palermo, Italy
    J Immunol 171:1961-8. 2003
    ....
  6. ncbi request reprint Biology of gammadelta T cells in tuberculosis and malaria
    F Dieli
    Department of Biopathology, University of Palermo, Italy
    Curr Mol Med 1:437-46. 2001
    ....
  7. ncbi request reprint Characterization of lung gamma delta T cells following intranasal infection with Mycobacterium bovis bacillus Calmette-Guérin
    Francesco Dieli
    Department of Biopathology, University of Palermo, Palermo, Italy
    J Immunol 170:463-9. 2003
    ....
  8. ncbi request reprint Reciprocal stimulation of gammadelta T cells and dendritic cells during the anti-mycobacterial immune response
    Francesco Dieli
    Dipartimento di Biopatologia, Universita di Palermo, Palermo, Italy
    Eur J Immunol 34:3227-35. 2004
    ..Consequently, stimulation of gammadelta T cells and their non-cognate interaction with DC could be applied as an immune adjuvant strategy to optimize vaccine-induced CD8 T cell immunity...
  9. ncbi request reprint Sequestration of T lymphocytes to body fluids in tuberculosis: reversal of anergy following chemotherapy
    F Dieli
    Institute of General Pathology, University of Palermo, 90134 Palermo, Italy
    J Infect Dis 180:225-8. 1999
    ..These results indicate that CD4 T cells recognizing a vast array of M. tuberculosis epitopes are compartmentalized at the site of disease in anergic patients but appear in peripheral blood after chemotherapy...
  10. ncbi request reprint Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancer
    Francesco Dieli
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Cancer Res 67:7450-7. 2007
    ..Moreover, gammadelta cell phenotypes and possibly serum TRAIL may constitute novel biomarkers of prognosis upon therapy with zoledronate + IL-2 in metastatic carcinoma...
  11. ncbi request reprint Advances in immunotherapy of castration-resistant prostate cancer: bisphosphonates, phosphoantigens and more
    Francesco Dieli
    Universita di Palermo, Dipartimento di Biopatologia e Metodologie Biomediche, Corso Tukory 211, 90134, Palermo, Italy
    Curr Opin Investig Drugs 9:1089-94. 2008
    ....
  12. pmc In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients
    S Meraviglia
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Clin Exp Immunol 161:290-7. 2010
    ....
  13. ncbi request reprint A human leucocyte antigen-DR1 transgene confers susceptibility to experimental allergic encephalomyelitis elicited by an epitope of myelin basic protein
    G Sireci
    Department of Biopathology, University of Palermo, Corso Tukory 211, 90134 Palermo, Italy
    Scand J Immunol 58:188-94. 2003
    ..These data could prove a useful tool in understanding the role played by different MBP epitopes in EAE...
  14. pmc Resistance of natural killer T cell-deficient mice to systemic Shwartzman reaction
    F Dieli
    Department of Biopathology, University of Palermo, Italy
    J Exp Med 192:1645-52. 2000
    ..These results suggest that the numerically small NKT cell population of normal mice apparently plays a mandatory role in the priming stage of the generalized Shwartzman reaction...
  15. ncbi request reprint gammadelta T cells condition dendritic cells in vivo for priming pulmonary CD8 T cell responses against Mycobacterium tuberculosis
    Nadia Caccamo
    Dipartimento di Biopatologia, Universita di Palermo, Palermo, Italy
    Eur J Immunol 36:2681-90. 2006
    ..Thus, strategies exploiting gammadelta T cell function and IFN-gamma production could be valuable for the design and testing of mucosal vaccines...
  16. ncbi request reprint In vitro effects of aminobisphosphonates on Vgamma9Vdelta2 T cell activation and differentiation
    V Ferlazzo
    Dept of Biopathology and Biomedical Methods, University of Palermo, 90134 Palermo, Italy
    Int J Immunopathol Pharmacol 19:309-17. 2006
    ..Accordingly, Vgamma9Vdelta2 T lymphocytes cultured with aminobisphosphonates and IL-2 showed a major content of IFN-gamma and acquired the ability to kill tumor target cells...
  17. ncbi request reprint Major histocompatibility complex regulation of interleukin-5 production in the mouse
    F Dieli
    Institute of General Pathology, University of Palermo, Italy
    Eur J Immunol 23:2897-902. 1993
    ..The influence of MHC on IL-5 production and IgA secretion in the mouse might be a possible basis for the association of MHC with IgA deficiency in humans...
  18. ncbi request reprint Differential activation of human gammadelta cells by nonpeptide phosphoantigens
    G Sireci
    Department of Biopathology, University of Palermo, Italy
    Eur J Immunol 31:1628-35. 2001
    ..This differential pattern of gammadelta cell activation by phosphoantigens could explain the stronger potencies of some of these agonists...
  19. pmc Dominant V beta 8 gene usage in response to TNP: failure to use other V beta chains following removal of V beta 8+ T cells by monoclonal antibody in vivo
    F Dieli
    Institute of General Pathology, University of Palermo, Italy
    Immunology 82:99-105. 1994
    ....
  20. ncbi request reprint Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2 T lymphocytes
    F Dieli
    Dipartimento di Biopatologia, , Palermo, Italy
    J Infect Dis 184:1082-5. 2001
    ..Granulysin and perforin, both detected in Vgamma9/Vdelta2 T lymphocytes, play a major role, which indicates that Vgamma9/Vdelta2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection...
  21. pmc Cytokine profile, HLA restriction and TCR sequence analysis of human CD4+ T clones specific for an immunodominant epitope of Mycobacterium tuberculosis 16-kDa protein
    N Caccamo
    Department of Biopathology, University of Palermo, 90134 Palermo, Italy
    Clin Exp Immunol 133:260-6. 2003
    ..The ability of peptide 91-110 to bind a wide range of HLA-DR molecules, and to stimulate a Th1-type interferon (IFN)-gamma response more readily, encourage the use of this peptide as a subunit vaccine component...
  22. doi request reprint Partial and ineffective activation of V gamma 9V delta 2 T cells by Mycobacterium tuberculosis-infected dendritic cells
    Serena Meraviglia
    Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universita di Palermo, Palermo, Italy
    J Immunol 185:1770-6. 2010
    ..tuberculosis. Overall, this study provides a further piece of information on the complex relationship between important players of innate immunity during mycobacterial infection...
  23. ncbi request reprint The level of soluble Granzyme A is elevated in the plasma and in the Vgamma9/Vdelta2 T cell culture supernatants of patients with active Behçet's disease
    A Accardo-Palumbo
    Section of Rheumatology and Clinical Immunology, University of Palermo, Italy
    Clin Exp Rheumatol 22:S45-9. 2004
    ..Among the cytotoxic cells, gamma/delta T cells participate in the early phases of the immune response and are known to express perforin and granzymes constitutively in agreement with their cytolytic pontential...
  24. ncbi request reprint Phenotypical and functional analysis of memory and effector human CD8 T cells specific for mycobacterial antigens
    Nadia Caccamo
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    J Immunol 177:1780-5. 2006
    ..Our study represents the first characterization of Ag-specific memory and effector CD8 T cells during TB and may help to understand the type of immune response that vaccine candidates should stimulate to achieve protection...
  25. ncbi request reprint Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human Vgamma9Vdelta2 naive, memory and effector T cell subsets
    Nadia Caccamo
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Eur J Immunol 35:1764-72. 2005
    ....
  26. ncbi request reprint Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a negative regulator of IL-1/TLR signaling
    Cecilia Garlanda
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, 90134 Palermo, Italy
    J Immunol 179:3119-25. 2007
    ..Accordingly, blocking IL-1beta and TNF-alpha with a mix of anti-cytokine Abs, significantly prolonged survival of Tir8(-/-) mice. Thus, TIR8/SIGIRR plays a key role in damping inflammation and tissue damage in M. tuberculosis infection...
  27. ncbi request reprint Analysis of memory and effector CD8+ T cell subsets in chronic graft-versus-host disease
    M D' Asaro
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita degli Studi di Palermo, Palermo, Italy
    Int J Immunopathol Pharmacol 22:195-205. 2009
    ....
  28. doi request reprint Prevention of the post-chemotherapy relapse of tuberculous infection by combined immunotherapy
    Simona Buccheri
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory, Palermo, Italy
    Tuberculosis (Edinb) 89:91-4. 2009
    ..These results represent a proof-of-principle, that the described CIT, when combined with chemotherapy, could have potential for future development of a shorter regimen of tuberculosis treatment...
  29. ncbi request reprint Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cells
    Nadia Caccamo
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Italy
    J Leukoc Biol 79:663-6. 2006
    ..The phenotypical conversion in men older than 30 years is mirrored by an increased proliferative response of Vgamma9/Vdelta2 T cells and a reduced interferon-gamma secretion upon stimulation with isopentenyl pyrophosphate in vitro...
  30. pmc Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection
    Diana Di Liberto
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, 90134 Palermo, Italy
    J Exp Med 205:2075-84. 2008
    ..tuberculosis. Thus, the D6 decoy receptor plays a key role in setting the balance between antimicrobial resistance, immune activation, and inflammation in M. tuberculosis infection...
  31. pmc Impaired contact hypersensitivity to trinitrochlorobenzene in interleukin-4-deficient mice
    F Dieli
    Institute of General Pathology, University of Palermo, Italy
    Immunology 98:71-9. 1999
    ..However, IL-4 KO mice developed a normal CH response to oxazolone, indicating that IL-4 was required for the CH reaction to TNCB, but not for that to oxazolone...
  32. ncbi request reprint Th0 to Th1 switch of CD4 T cell clones specific from the 16-kDa antigen of Mycobacterium tuberculosis after successful therapy: lack of involvement of epitope repertoire and HLA-DR
    Nadia Caccamo
    Dipartimento di Biopatologia, Universita di Palermo, Corso Tukory, 211, Palermo 90134, Italy
    Immunol Lett 98:253-8. 2005
    ..These findings indicate that additional factors, such as the cytokine environment and/or costimulatory molecules, determine the Th phenotype of CD4 T cells during tuberculosis...
  33. doi request reprint Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection
    Nadia Caccamo
    Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, University of Palermo, Palermo, Italy
    Eur J Immunol 40:2211-20. 2010
    ..Our results suggest that phenotypic and functional signatures of CD4(+) T cells may serve as immunological correlates of protection and curative host responses, and be a useful tool to monitor the efficacy of anti-mycobacterial therapy...
  34. doi request reprint Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes
    Matilde Todaro
    Department of Surgical and Oncological Sciences, University of Palermo, Palermo, Italy
    J Immunol 182:7287-96. 2009
    ..We conclude that intentional activation of Vgamma9Vdelta2 T cells by zoledronate may substantially increase antitumor activities and represent a novel strategy for colon cancer immunotherapy...
  35. ncbi request reprint Increased percentages of tumor necrosis factor-alpha+/interferon-gamma+ T [corrected] lymphocytes and calprotectin+/tumor necrosis factor-alpha+ monocytes in patients with acute Kawasaki disease
    G Guggino
    Department of Medical and Phorensic Biopathology and Biotechnology, University of Palermo, Italy
    Int J Immunopathol Pharmacol 25:99-105. 2012
    ..Our results should be confirmed by further studies enrolling more patients and controls than those analyzed in our study...
  36. ncbi request reprint Optimizing tumor-reactive γδ T cells for antibody-based cancer immunotherapy
    S Meraviglia
    Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universita di Palermo, Palermo, Italy
    Curr Mol Med 10:719-26. 2010
    ..Thus, we propose that enhancing the efficacy of mAbs by combination with γδ T cell activation may have considerable therapeutic potential for a variety of malignancies, most especially for patients whose FcγR alleles impair ADCC...
  37. doi request reprint Survivin is regulated by interleukin-4 in colon cancer stem cells
    A B Di Stefano
    Department of Surgical and Oncological Sciences, University of Palermo, Palermo, Italy
    J Cell Physiol 225:555-61. 2010
    ..These findings shed more light on the molecular mechanisms involved in IL-4-mediated chemoresistance...
  38. doi request reprint A continuous infusion of a minor histocompatibility antigen-immunodominant peptide induces a delay of male skin graft rejection
    Guido Sireci
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, 90134 Palermo, Italy
    Immunobiology 214:703-11. 2009
    ..Taken all together, our data demonstrate that a continuous infusion of an immunodominant HY peptide induces a T CD8 suppressor subset able to inhibit immune responses to male tissues and cells...
  39. doi request reprint Prophylaxis of lipopolysaccharide-induced shock by alpha-galactosylceramide
    Guido Sireci
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, 90134 Palermo, Italy
    J Leukoc Biol 84:550-60. 2008
    ..Taken together, our data demonstrated that KRN7000, injected from 6 to 12 days before the first administration of LPS, prevented endotoxin shock by inhibiting IFN-gamma, TNF-alpha, and MCP-1 release...
  40. ncbi request reprint Aminobisphosphonates as new weapons for gammadelta T Cell-based immunotherapy of cancer
    Nadia Caccamo
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, Palermo 90134 Italy
    Curr Med Chem 15:1147-53. 2008
    ....
  41. ncbi request reprint Aminobisphosphonate-activated gammadelta T cells in immunotherapy of cancer: doubts no more
    Nadia Caccamo
    Universita di Palermo, Dipartimento di Biopatologia e Metodologie Biomediche, Corso Tukory, 211 90134 Palermo, Italy
    Expert Opin Biol Ther 8:875-83. 2008
    ..Activated V gamma 9 V delta 2 T cells are able to kill most tumour cells because of recognition by T cell receptor and natural killer receptors...
  42. doi request reprint V gamma 9V delta 2 T lymphocytes efficiently recognize and kill zoledronate-sensitized, imatinib-sensitive, and imatinib-resistant chronic myelogenous leukemia cells
    Matilde D'Asaro
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    J Immunol 184:3260-8. 2010
    ..We conclude that intentional activation of Vgamma9Vdelta2 T cells by zoledronate may substantially increase their antileukemia activities and represent a novel strategy for CML immunotherapy...
  43. ncbi request reprint Gammadelta T cell modulation in anticancer treatment
    Nadia Caccamo
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Curr Cancer Drug Targets 10:27-36. 2010
    ....
  44. pmc Analysis of Mycobacterium tuberculosis-specific CD8 T-cells in patients with active tuberculosis and in individuals with latent infection
    Nadia Caccamo
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    PLoS ONE 4:e5528. 2009
    ....
  45. pmc Anti-16-kilodalton mycobacterial protein immunoglobulin m levels in healthy but purified protein derivative-reactive children decrease after chemoprophylaxis
    Guido Sireci
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita degli Studi di Palermo, Corso Tukory 211, 90100 Palermo, Italy
    Clin Vaccine Immunol 14:1231-4. 2007
    ..After chemotherapy, IgM and IgG responses decreased for TB patients and PPD-positive subjects. Monitoring of anti-M. tuberculosis HSP16 responses could assist in the management of pediatric TB...
  46. ncbi request reprint Analysis of the immune response induced by a single xenoantigen in vivo
    Guido Sireci
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, 90134 Palermo, Italy
    Immunol Lett 98:245-52. 2005
    ..In addition, we detected xenoreactive IgM and IgG2 antibodies. Our data suggest that HLA-DR1 xenoantigen may be recognized through direct or indirect pathway and provide additional information on mouse anti-human HLA immune response...
  47. ncbi request reprint Pivotal advance: alpha-galactosylceramide induces protection against lipopolysaccharide-induced shock
    Guido Sireci
    Dipartimento di Biopatologia e Metodologie Biomeeiche, Universita di Palermo, Palermo, Italy
    J Leukoc Biol 81:607-22. 2007
    ....
  48. ncbi request reprint Immunoregulatory role of Jalpha281 T cells in aged mice developing lupus-like nephritis
    Guido Sireci
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    Eur J Immunol 37:425-33. 2007
    ..Our results provide the first evidence of a lupus-like syndrome in non-autoimmune mice, supporting an age-related immunoregulatory role of Jalpha281+ cells, probably associated with the activation of marginal zone B cells...
  49. pmc Humoral and cell mediated immune response to cow's milk proteins in Behçet's disease
    G Triolo
    Dipartimento Biomedico di Medicina Interna e Specialistica Section of Rheumatology and Clinical Immunology, Policlinico Universitario, Palermo, Italy
    Ann Rheum Dis 61:459-62. 2002
    ..To investigate the humoral and cellular immune response against cow's milk proteins in Behçet's disease and to distinguish any behaviour during active or inactive disease...
  50. ncbi request reprint IL-4 depletion enhances host resistance and passive IgA protection against tuberculosis infection in BALB/c mice
    Simona Buccheri
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Italy
    Eur J Immunol 37:729-37. 2007
    ..The described novel immunotherapy, combining treatments with anti-IL-4, IgA antibody and IFN-gamma, has potential for translation toward the passive immunoprophylaxis of tuberculosis...
  51. pmc Vgamma9/Vdelta2 T lymphocytes in Italian patients with Behçet's disease: evidence for expansion, and tumour necrosis factor receptor II and interleukin-12 receptor beta1 expression in active disease
    Giovanni Triolo
    Department of Internal Medicine, Section of Rheumatology and Clinical Immunology, University of Palermo, Palermo, Italy
    Arthritis Res Ther 5:R262-8. 2003
    ..These results indicate that Vgamma9/Vdelta2 T cell activation is correlated with disease progression and probably involved in the pathogenesis...
  52. doi request reprint Expansion of intracellular IFN-γ positive lymphocytes during Mycoplasma agalactiae infection in sheep
    M P La Manna
    Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universita di Palermo, Corso Tukory 211, 90131 Palermo, Italy
    Res Vet Sci 91:e64-7. 2011
    ..agalactiae infection...
  53. ncbi request reprint IL-5 enhances in vitro and in vivo antigen-specific IgA production in MHC genetically determined low IL-5 responder mice
    F Dieli
    Institute of General Pathology, University of Palermo, Italy
    Cell Immunol 163:309-13. 1995
    ..Our results therefore indicate that IL-5 in vivo enhances antigen-specific IgA production in MHC-determined low IL-5 responder mice and suggest an explanation for IgA deficiency in humans...
  54. doi request reprint Tuning inflammation in tuberculosis: the role of decoy receptors
    Diana Di Liberto
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, Palermo 90134, Italy
    Microbes Infect 11:821-7. 2009
    ..In this review we discuss on recent findings demonstrating that these receptors set the balance between antimicrobial resistance, immune activation and inflammatory response in Mycobacterium tuberculosis infection...
  55. doi request reprint Tumorigenic and metastatic activity of human thyroid cancer stem cells
    Matilde Todaro
    Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Laboratory, University of Palermo, Palermo, Italy
    Cancer Res 70:8874-85. 2010
    ..The identification of tumorigenic and metastagenic thyroid cancer cells may provide unprecedented preclinical tools for development and preclinical validation of novel targeted therapies...
  56. pmc Decreased serum granulysin levels in childhood tuberculosis which reverse after therapy
    Diana Di Liberto
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Corso Tukory 211, 90134 Palermo, Italy
    Tuberculosis (Edinb) 87:322-8. 2007
    ..We propose that serum granulysin levels may provide a marker of disease activity in childhood TB and might be useful for monitoring improvement after chemotherapy...
  57. ncbi request reprint CXCR5 identifies a subset of Vgamma9Vdelta2 T cells which secrete IL-4 and IL-10 and help B cells for antibody production
    Nadia Caccamo
    Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
    J Immunol 177:5290-5. 2006
    ..These properties portray CXCR5+ Vgamma9Vdelta2 T cells as a distinct memory T cell subset with B cell helper function...
  58. ncbi request reprint Characterization of HLA-DR- and TCR-binding residues of an immunodominant and genetically permissive peptide of the 16-kDa protein of Mycobacterium tuberculosis
    Nadia Caccamo
    Department of Biopathology, University of Palermo, Corso Tukory 211, I 90134 Palermo, Italy
    Eur J Immunol 34:2220-9. 2004
    ..Our results could be useful to design peptides with altered HLA anchor residues or TCR interaction sites to achieve remarkable increase in activity and to study their vaccine potential...
  59. ncbi request reprint Toxocara canis infection induces antigen-specific IL-10 and IFNgamma production in pregnant dogs and their puppies
    Alessandra Torina
    Istituto Zooprofilattico Sperimentale della Sicilia, Via G Marinuzzi 3, 90134 Palermo, Italy
    Vet Immunol Immunopathol 108:247-51. 2005
    ..In conclusion, our data suggests that BMC of infected dogs have a particular modification of IL-10 and IFNgamma synthesis. These data could be the basis to design immunotherapeutic approaches...
  60. ncbi request reprint Research on complement: old issues revisited and a novel sphere of influence
    Liliana Clemenza
    Department of Biopathology and Biomedical Methodologies, University of Palermo, Italy, Corso Tukory 211, Italy
    Trends Immunol 24:292-6. 2003
    ..We cover papers selected from studies presented at the XIX International Complement Workshop, held in Palermo in September 2002, and published within the past six months...
  61. ncbi request reprint Tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia
    Manlio Tolomeo
    Centro Interdipartimentale di Ricerca in Oncologia Clinica, Policlinico P Giaccone, Universita di Palermo, Italy
    Anticancer Agents Med Chem 9:853-63. 2009
    ..In this review we will discuss the in vitro and in vivo results obtained with the novel tyrosine kinase inhibitors developed to overcome imatinib resistance in Bcr-Abl expressing hematologiocal disorders...
  62. ncbi request reprint Induction of gammadelta T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo
    Francesco Dieli
    Blood 102:2310-1. 2003
  63. ncbi request reprint In vitro T-cell immunogenicity of oligopeptides derived from the region 92-110 of the 16-kDa protein of Mycobacterium tuberculosis
    Szilvia Bosze
    Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Eôtvos L University Budapest 112, POB 32, H 1518, Hungary
    Biopolymers 76:467-76. 2004
    ....
  64. ncbi request reprint Homing and memory patterns of human gammadelta T cells in physiopathological situations
    Luca Battistini
    Neuroimmunology Unit, IRCCS Santa Lucia Foundation, 00179 Rome, Italy
    Microbes Infect 7:510-7. 2005
    ..We review here these recently studied features of Vgamma9Vdelta2 T lymphocyte biology and the roles they play in infectious and autoimmune diseases...
  65. ncbi request reprint Stilbene-based anticancer agents: resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism
    Daniele Simoni
    Dipartimento di Scienze Farmaceutiche, Via Fossato di Mortara 17 19, Universita di Ferrara, 44100 Ferrara, Italy
    Bioorg Med Chem Lett 16:3245-8. 2006
    ..The potent pro-apoptotic activity shown by compound 6b and its effects on cell cycle make this compound of great interest for further investigations...
  66. pmc ESAT-6 peptide recognition by bovine CD8+ lymphocytes of naturally infected cows in herds from southern Italy
    Fabrizio Vitale
    Istituto Zooprofilattico Sperimentale della Sicilia, Via G Marinuzzi 3, 90100 Palermo, Italia
    Clin Vaccine Immunol 13:530-3. 2006
    ..We found that bovine CD8+ T cells recognized 10 out of 11 ESAT-6 peptides tested...
  67. ncbi request reprint Drug-induced expansion and differentiation of V gamma 9V delta 2 T cells in vivo: the role of exogenous IL-2
    Rita Casetti
    National Institute for Infectious Diseases, Lazzaro Spallanzani, Istituto di Ricerca e Cura a Carattere Scientifico, Rome, Italy
    J Immunol 175:1593-8. 2005
    ..These results may be relevant for designing novel (or modifying current) immunotherapeutic trials with nitrogen-containing bisphosphonate or pyrophosphomonoester drugs...
  68. ncbi request reprint Gamma delta T cells inhibit in vitro growth of the asexual blood stages of Plasmodium falciparum by a granule exocytosis-dependent cytotoxic pathway that requires granulysin
    Salah E Farouk
    Department of Immunology, Stockholm University, Svante Arrheniusvägen 16, S 10691 Stockholm, Sweden
    Eur J Immunol 34:2248-56. 2004
    ..falciparum is based on the granule exocytosis-dependent cytotoxic pathway and that the presence of granulysin is essential to maintain efficient killing...
  69. ncbi request reprint ANP presence in the hypothalamic suprachiasmatic nucleus of developing rat
    Elvira Farina Lipari
    Dipartimento di Medicina Sperimentale, Sezione Anatomia Umana, Universita di Palermo
    Ital J Anat Embryol 112:19-25. 2007
    ..Moreover, ANP and vasopressin appear at the same developmental stage since both the peptides are involved in the homeostasis of body fluids...