Research Topics
Genomes and Genes | Mauro Di IanniSummaryAffiliation: University of L'Aquila Country: Italy Publications
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Detail Information
Publications
T regulatory cell separation for clinical applicationMauro Di Ianni
Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
Transfus Apher Sci 47:213-6. 2012..Cells isolated by means of this approach can be used in allogeneic hematopoietic stem cell transplantation to reduce the incidence and severity of GvHD without bystander inhibition of general immunity...- Activated autologous T cells exert an anti-B-cell chronic lymphatic leukemia effect in vitro and in vivoMauro Di Ianni
Department of Internal Medicine and Public Health, Chair of Hematology, University of L Aquila, Italy
Cytotherapy 11:86-96. 2009..The impact of chronic lymphatic leukemia (CLL) tumor burden on the autologous immune system has already been demonstrated. This study attempted to elucidate the molecular mechanisms underlying T-cell immunologic deficiencies in CLL... 
Immunomagnetic isolation of CD4+CD25+FoxP3+ natural T regulatory lymphocytes for clinical applicationsM Di Ianni
Department of Internal Medicine and Public Health, Chair of Hematology, University of L Aquila, Italy
Clin Exp Immunol 156:246-53. 2009..Cells isolated by means of this approach might be used in allogeneic haematopoietic cell transplantation to facilitate engraftment and reduce the incidence and severity of GvHD without abrogating the potential graft-versus-tumour effect...- Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantationMauro Di Ianni
Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
Blood 117:3921-8. 2011..This study provides evidence that Tregs are a conserved mechanism in humans... - Immunoselection and clinical use of T regulatory cells in HLA-haploidentical stem cell transplantationMauro Di Ianni
Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
Best Pract Res Clin Haematol 24:459-66. 2011.... - Mesenchymal cells recruit and regulate T regulatory cellsMauro Di Ianni
Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
Exp Hematol 36:309-18. 2008..Because multipotent mesenchymal stromal cells (MSCs) exert an immune regulatory function and suppress T-cell proliferation, this in vitro study investigated their role in Treg recruitment and function... - High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk non-Hodgkin lymphomaFranca Falzetti
Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, University of Perugia Medical School, Perugia, Italy
Clin Exp Med 12:165-71. 2012..Its good tolerance and acceptable toxicity suggest that it may a very useful in the management of non-Hodgkin lymphoma... 
Interleukin-7-engineered mesenchymal cells: in vitro effects on naive T-cell populationPaolo Sportoletti
Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, Perugia University, Perugia, Italy
Biol Blood Marrow Transplant 12:1250-60. 2006..Due to the continuous production of IL-7 by engineered cells, our system is more efficacious than exogenous IL-7...- Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLLEmanuela Rosati
Department of Clinical and Experimental Medicine, General Pathology and Immunology Section, University of Perugia, Perugia, Italy
Blood 116:2713-23. 2010..Overall, our findings show that ER triggers an essential pathway for B-CLL cell apoptosis and suggest that genetic and pharmacologic manipulation of ER signaling could represent an important therapeutic strategy... - Large-scale generation of human allodepleted anti-3rd party lymphocytesMaria De Ioanni
Department of Clinical and Experimental Medicine, IRCCS Foundation on Transplantation Biotechnologies, University of Perugia, Italy
Blood Cells Mol Dis 40:106-12. 2008..These anti-3rd party lymphocytes contain a large adaptive T regulatory cell subset which might contribute to in vitro and in vivo immune modulation... - Hematopoietic stem cell transplantation from alternative donors for high-risk acute leukemia: the haploidentical optionFranco Aversa
Hematopoietic Stem Cell Transplant Unit, Section of Hematology and Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia 06100, Italy
Curr Stem Cell Res Ther 2:105-12. 2007.... - Notch1 modulates mesenchymal stem cells mediated regulatory T-cell inductionBeatrice Del Papa
Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
Eur J Immunol 43:182-7. 2013..Together, these findings indicate that activation of the Notch1 pathway is a novel mechanism in the human Treg-cell induction mediated by MSCs... - Interleukin 7-engineered stromal cells: a new approach for hastening naive T cell recruitmentMauro Di Ianni
University of Perugia, 06123 Perugia, Italy
Hum Gene Ther 16:752-64. 2005..Because of their efficient cytokine production and homing, IL-7-engineered stromal cells might be an ideal vehicle to hasten immunological reconstitution in T cell-depleted hosts... - γ-Secretase inhibitor I induces apoptosis in chronic lymphocytic leukemia cells by proteasome inhibition, endoplasmic reticulum stress increase and notch down-regulationEmanuela Rosati
Department of Clinical and Experimental Medicine, General Pathology and Immunology Section, University of Perugia, Perugia, Italy
Int J Cancer 132:1940-53. 2013..These findings suggest the potential relevance of simultaneously targeting these three important apoptosis regulators as a novel therapeutic strategy for CLL... - Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cellsEmanuela Rosati
Department of Clinical and Experimental Medicine, General Pathology and Immunology Section, University of Perugia, Perugia
Blood 113:856-65. 2009..Overall, our findings show that Notch signaling plays a critical role in B-CLL cell survival and apoptosis resistance and suggest that it could be a novel potential therapeutic target... - NeoR-based transduced T lymphocytes detected by real-time quantitative polymerase chain reactionGigliola Venditti
Department of Clinical and Experimental Medicine, Haematology and Clinical Immunology Section, University of Perugia, Perugia, Italy 60122
J Hematother Stem Cell Res 12:83-91. 2003..This study precisely quantified the percentages of cells transduced by the retroviral vector and could have major implications in gene therapy studies... - Effect of trichostatin a and 5'-azacytidine on transgene reactivation in U937 transduced cellsAndrea Bartoli
Department of Clinical and Experimental Medicine, General Pathology and Immunology Section, General Hospital, University of Perugia, Monteluce, 06100 Perugia, Italy
Pharmacol Res 48:111-8. 2003.... - Graft engineering for allogeneic haploidentical stem cell transplantationAntonio Tabilio
Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology, University of Perugia, Perugia, Italy
Blood Cells Mol Dis 33:274-80. 2004..Modern time-saving automated graft processing devices ensure reproducibility, reliability, and biological safety, which make widespread application of the haploidentical transplant currently feasible... - B-chronic lymphocytic leukemia cells exert an in vitro cytotoxicity mediated by tumor necrosis factor alphaEmanuela Rosati
Department of Clinical and Experimental Medicine, University of Perugia, Via Brunamonti, General Hospital-Monteluce, 06122 Perugia, Italy
Leuk Res 29:829-39. 2005..We conclude that a group of B-CLL patients with progressive disease have leukemic B cells able to exert in vitro a TNFalpha-mediated cytotoxicity, which is modulated by cytokines... - CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised miceMaria Paola Martelli
Institute of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy
Blood 116:3907-22. 2010..This study provides further evidence that NPM1 mutation is a founder genetic lesion and has potential implications for the cell-of-origin and targeted therapy of NPM1-mutated AML... - High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk Hodgkin's lymphomaMauro Di Ianni
Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, University of Perugia Medical School, I 06100 Perugia, Italy
Hematology 17:23-7. 2012..Autologous stem cell transplantation (ASCT) generally provides good results in Hodgkin's lymphoma (HL). We studied a high-dose chemotherapy regimen based on thiotepa, etoposide and carboplatin (TECA)... - Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantationAgostinho Carvalho
Microbiology, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
Exp Hematol 37:1022-9. 2009..Discovery of genetic variations in the genes encoding for Toll-like receptors (TLRs) has highlighted a potential link between genomic variation of the host and susceptibility to infections... - Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunityCristina Cunha
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
Blood 116:5394-402. 2010.... - Homing and survival of thymidine kinase-transduced human T cells in NOD/SCID miceMauro Di Ianni
Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, Perugia University, Perugia, Italy
Cancer Gene Ther 9:756-61. 2002..Lack of full response to GCV may account for cases of GvHD in patients receiving tk-transduced T lymphocytes... - Unusual onset of venous thromboembolism and heparin-induced thrombocytopenia in a patient with essential thrombocythemiaMario Lapecorella
Centro Emofilia e Trombosi, Unità Operativa Medicina Interna 2, Ematologia, Università de L Aquila, Ospedale San Salvatore, L Aquila, Italy
Blood Coagul Fibrinolysis 21:85-90. 2010..Bone marrow examination performed after clinical improvement revealed the patient to be affected by essential thrombocythemia... - Evidence of jak2 val617phe positive essential thrombocythemia with splanchnic thrombosis during estroprogestinic treatmentMario Lapecorella
Centro Emofilia e Trombosi Unità Operativa Medicina Interna 2 Ematologia, Università de L Aquila Ospedale San Salvatore, Coppito L Aquila, Italy
Blood Coagul Fibrinolysis 19:453-7. 2008..She was found to carry the kinase gene Janus kinase 2 mutation... - Treating two concurrent B-cell and T-cell lymphoid neoplasms with alemtuzumab monotherapyNiccolò Bolli
Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Section, University of Perugia, Italy
Lancet Oncol 5:64-5. 2004 - Toxic epidermal necrolysis in a patient with primary myelofibrosis receiving thalidomide therapyMarianna Colagrande
Department of Internal Medicine and Public Health, University of L Aquila, Via Vetoio snc, Coppito, 67100, L Aquila, Italy
Int J Hematol 89:76-9. 2009..The patient was treated with thalidomide but after 20 days developed life-threatening toxic epidermal necrolysis (TEN). To the best of our knowledge this is the first case of TEN in a patient with PMF under thalidomide therapy...