Mauro Di Ianni

Summary

Affiliation: University of L'Aquila
Country: Italy

Publications

  1. doi request reprint T regulatory cell separation for clinical application
    Mauro Di Ianni
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Transfus Apher Sci 47:213-6. 2012
  2. pmc Immunomagnetic isolation of CD4+CD25+FoxP3+ natural T regulatory lymphocytes for clinical applications
    M Di Ianni
    Department of Internal Medicine and Public Health, Chair of Hematology, University of L Aquila, Italy
    Clin Exp Immunol 156:246-53. 2009
  3. doi request reprint Activated autologous T cells exert an anti-B-cell chronic lymphatic leukemia effect in vitro and in vivo
    Mauro Di Ianni
    Department of Internal Medicine and Public Health, Chair of Hematology, University of L Aquila, Italy
    Cytotherapy 11:86-96. 2009
  4. doi request reprint Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    Mauro Di Ianni
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Blood 117:3921-8. 2011
  5. doi request reprint Immunoselection and clinical use of T regulatory cells in HLA-haploidentical stem cell transplantation
    Mauro Di Ianni
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Best Pract Res Clin Haematol 24:459-66. 2011
  6. doi request reprint Mesenchymal cells recruit and regulate T regulatory cells
    Mauro Di Ianni
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Exp Hematol 36:309-18. 2008
  7. doi request reprint High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk non-Hodgkin lymphoma
    Franca Falzetti
    Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, University of Perugia Medical School, Perugia, Italy
    Clin Exp Med 12:165-71. 2012
  8. ncbi request reprint Interleukin 7-engineered stromal cells: a new approach for hastening naive T cell recruitment
    Mauro Di Ianni
    University of Perugia, 06123 Perugia, Italy
    Hum Gene Ther 16:752-64. 2005
  9. ncbi request reprint Interleukin-7-engineered mesenchymal cells: in vitro effects on naive T-cell population
    Paolo Sportoletti
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, Perugia University, Perugia, Italy
    Biol Blood Marrow Transplant 12:1250-60. 2006
  10. ncbi request reprint Hematopoietic stem cell transplantation from alternative donors for high-risk acute leukemia: the haploidentical option
    Franco Aversa
    Hematopoietic Stem Cell Transplant Unit, Section of Hematology and Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia 06100, Italy
    Curr Stem Cell Res Ther 2:105-12. 2007

Collaborators

Detail Information

Publications30

  1. doi request reprint T regulatory cell separation for clinical application
    Mauro Di Ianni
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Transfus Apher Sci 47:213-6. 2012
    ..Cells isolated by means of this approach can be used in allogeneic hematopoietic stem cell transplantation to reduce the incidence and severity of GvHD without bystander inhibition of general immunity...
  2. pmc Immunomagnetic isolation of CD4+CD25+FoxP3+ natural T regulatory lymphocytes for clinical applications
    M Di Ianni
    Department of Internal Medicine and Public Health, Chair of Hematology, University of L Aquila, Italy
    Clin Exp Immunol 156:246-53. 2009
    ..Cells isolated by means of this approach might be used in allogeneic haematopoietic cell transplantation to facilitate engraftment and reduce the incidence and severity of GvHD without abrogating the potential graft-versus-tumour effect...
  3. doi request reprint Activated autologous T cells exert an anti-B-cell chronic lymphatic leukemia effect in vitro and in vivo
    Mauro Di Ianni
    Department of Internal Medicine and Public Health, Chair of Hematology, University of L Aquila, Italy
    Cytotherapy 11:86-96. 2009
    ..The impact of chronic lymphatic leukemia (CLL) tumor burden on the autologous immune system has already been demonstrated. This study attempted to elucidate the molecular mechanisms underlying T-cell immunologic deficiencies in CLL...
  4. doi request reprint Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
    Mauro Di Ianni
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Blood 117:3921-8. 2011
    ..This study provides evidence that Tregs are a conserved mechanism in humans...
  5. doi request reprint Immunoselection and clinical use of T regulatory cells in HLA-haploidentical stem cell transplantation
    Mauro Di Ianni
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Best Pract Res Clin Haematol 24:459-66. 2011
    ....
  6. doi request reprint Mesenchymal cells recruit and regulate T regulatory cells
    Mauro Di Ianni
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Exp Hematol 36:309-18. 2008
    ..Because multipotent mesenchymal stromal cells (MSCs) exert an immune regulatory function and suppress T-cell proliferation, this in vitro study investigated their role in Treg recruitment and function...
  7. doi request reprint High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk non-Hodgkin lymphoma
    Franca Falzetti
    Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, University of Perugia Medical School, Perugia, Italy
    Clin Exp Med 12:165-71. 2012
    ..Its good tolerance and acceptable toxicity suggest that it may a very useful in the management of non-Hodgkin lymphoma...
  8. ncbi request reprint Interleukin 7-engineered stromal cells: a new approach for hastening naive T cell recruitment
    Mauro Di Ianni
    University of Perugia, 06123 Perugia, Italy
    Hum Gene Ther 16:752-64. 2005
    ..Because of their efficient cytokine production and homing, IL-7-engineered stromal cells might be an ideal vehicle to hasten immunological reconstitution in T cell-depleted hosts...
  9. ncbi request reprint Interleukin-7-engineered mesenchymal cells: in vitro effects on naive T-cell population
    Paolo Sportoletti
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, Perugia University, Perugia, Italy
    Biol Blood Marrow Transplant 12:1250-60. 2006
    ..Due to the continuous production of IL-7 by engineered cells, our system is more efficacious than exogenous IL-7...
  10. ncbi request reprint Hematopoietic stem cell transplantation from alternative donors for high-risk acute leukemia: the haploidentical option
    Franco Aversa
    Hematopoietic Stem Cell Transplant Unit, Section of Hematology and Immunology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia 06100, Italy
    Curr Stem Cell Res Ther 2:105-12. 2007
    ....
  11. ncbi request reprint Large-scale generation of human allodepleted anti-3rd party lymphocytes
    Maria De Ioanni
    Department of Clinical and Experimental Medicine, IRCCS Foundation on Transplantation Biotechnologies, University of Perugia, Italy
    Blood Cells Mol Dis 40:106-12. 2008
    ..These anti-3rd party lymphocytes contain a large adaptive T regulatory cell subset which might contribute to in vitro and in vivo immune modulation...
  12. doi request reprint Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLL
    Emanuela Rosati
    Department of Clinical and Experimental Medicine, General Pathology and Immunology Section, University of Perugia, Perugia, Italy
    Blood 116:2713-23. 2010
    ..Overall, our findings show that ER triggers an essential pathway for B-CLL cell apoptosis and suggest that genetic and pharmacologic manipulation of ER signaling could represent an important therapeutic strategy...
  13. doi request reprint γ-Secretase inhibitor I induces apoptosis in chronic lymphocytic leukemia cells by proteasome inhibition, endoplasmic reticulum stress increase and notch down-regulation
    Emanuela Rosati
    Department of Clinical and Experimental Medicine, General Pathology and Immunology Section, University of Perugia, Perugia, Italy
    Int J Cancer 132:1940-53. 2013
    ..These findings suggest the potential relevance of simultaneously targeting these three important apoptosis regulators as a novel therapeutic strategy for CLL...
  14. doi request reprint Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction
    Beatrice Del Papa
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Eur J Immunol 43:182-7. 2013
    ..Together, these findings indicate that activation of the Notch1 pathway is a novel mechanism in the human Treg-cell induction mediated by MSCs...
  15. doi request reprint Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells
    Emanuela Rosati
    Department of Clinical and Experimental Medicine, General Pathology and Immunology Section, University of Perugia, Perugia
    Blood 113:856-65. 2009
    ..Overall, our findings show that Notch signaling plays a critical role in B-CLL cell survival and apoptosis resistance and suggest that it could be a novel potential therapeutic target...
  16. ncbi request reprint Effect of trichostatin a and 5'-azacytidine on transgene reactivation in U937 transduced cells
    Andrea Bartoli
    Department of Clinical and Experimental Medicine, General Pathology and Immunology Section, General Hospital, University of Perugia, Monteluce, 06100 Perugia, Italy
    Pharmacol Res 48:111-8. 2003
    ....
  17. doi request reprint "Designed" grafts for HLA-haploidentical stem cell transplantation
    Massimo F Martelli
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy
    Blood 123:967-73. 2014
    ..Future strategies will focus on enhancing the clinical benefit of T-regulatory cells by increasing their number and strengthening their function. ..
  18. ncbi request reprint NeoR-based transduced T lymphocytes detected by real-time quantitative polymerase chain reaction
    Gigliola Venditti
    Department of Clinical and Experimental Medicine, Haematology and Clinical Immunology Section, University of Perugia, Perugia, Italy 60122
    J Hematother Stem Cell Res 12:83-91. 2003
    ..This study precisely quantified the percentages of cells transduced by the retroviral vector and could have major implications in gene therapy studies...
  19. doi request reprint NOTCH and NF-κB interplay in chronic lymphocytic leukemia is independent of genetic lesion
    Stefano Baldoni
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Int J Hematol 98:153-7. 2013
    ..Our results show that in CLL, NF-κB regulators and Jagged are both unmutated, suggesting that the Jagged-mediated interplay between NF-κB and NOTCH is independent of genetic lesions. ..
  20. ncbi request reprint Graft engineering for allogeneic haploidentical stem cell transplantation
    Antonio Tabilio
    Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology, University of Perugia, Perugia, Italy
    Blood Cells Mol Dis 33:274-80. 2004
    ..Modern time-saving automated graft processing devices ensure reproducibility, reliability, and biological safety, which make widespread application of the haploidentical transplant currently feasible...
  21. ncbi request reprint B-chronic lymphocytic leukemia cells exert an in vitro cytotoxicity mediated by tumor necrosis factor alpha
    Emanuela Rosati
    Department of Clinical and Experimental Medicine, University of Perugia, Via Brunamonti, General Hospital Monteluce, 06122 Perugia, Italy
    Leuk Res 29:829-39. 2005
    ..We conclude that a group of B-CLL patients with progressive disease have leukemic B cells able to exert in vitro a TNFalpha-mediated cytotoxicity, which is modulated by cytokines...
  22. doi request reprint CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice
    Maria Paola Martelli
    Institute of Hematology and Clinical Immunology, University of Perugia, Perugia, Italy
    Blood 116:3907-22. 2010
    ..This study provides further evidence that NPM1 mutation is a founder genetic lesion and has potential implications for the cell-of-origin and targeted therapy of NPM1-mutated AML...
  23. doi request reprint Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation
    Agostinho Carvalho
    Microbiology, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Exp Hematol 37:1022-9. 2009
    ..Discovery of genetic variations in the genes encoding for Toll-like receptors (TLRs) has highlighted a potential link between genomic variation of the host and susceptibility to infections...
  24. doi request reprint High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk Hodgkin's lymphoma
    Mauro Di Ianni
    Department of Clinical and Experimental Medicine, Section of Hematology and Clinical Immunology, University of Perugia Medical School, I 06100 Perugia, Italy
    Hematology 17:23-7. 2012
    ..Autologous stem cell transplantation (ASCT) generally provides good results in Hodgkin's lymphoma (HL). We studied a high-dose chemotherapy regimen based on thiotepa, etoposide and carboplatin (TECA)...
  25. doi request reprint Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity
    Cristina Cunha
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Blood 116:5394-402. 2010
    ....
  26. ncbi request reprint Homing and survival of thymidine kinase-transduced human T cells in NOD/SCID mice
    Mauro Di Ianni
    Hematology and Clinical Immunology Section, Department of Clinical and Experimental Medicine, Perugia University, Perugia, Italy
    Cancer Gene Ther 9:756-61. 2002
    ..Lack of full response to GCV may account for cases of GvHD in patients receiving tk-transduced T lymphocytes...
  27. doi request reprint Evidence of jak2 val617phe positive essential thrombocythemia with splanchnic thrombosis during estroprogestinic treatment
    Mario Lapecorella
    Centro Emofilia e Trombosi Unità Operativa Medicina Interna 2 Ematologia, Università de L Aquila Ospedale San Salvatore, Coppito L Aquila, Italy
    Blood Coagul Fibrinolysis 19:453-7. 2008
    ..She was found to carry the kinase gene Janus kinase 2 mutation...
  28. doi request reprint Unusual onset of venous thromboembolism and heparin-induced thrombocytopenia in a patient with essential thrombocythemia
    Mario Lapecorella
    Centro Emofilia e Trombosi, Unità Operativa Medicina Interna 2, Ematologia, Università de L Aquila, Ospedale San Salvatore, L Aquila, Italy
    Blood Coagul Fibrinolysis 21:85-90. 2010
    ..Bone marrow examination performed after clinical improvement revealed the patient to be affected by essential thrombocythemia...
  29. doi request reprint Toxic epidermal necrolysis in a patient with primary myelofibrosis receiving thalidomide therapy
    Marianna Colagrande
    Department of Internal Medicine and Public Health, University of L Aquila, Via Vetoio snc, Coppito, 67100, L Aquila, Italy
    Int J Hematol 89:76-9. 2009
    ..The patient was treated with thalidomide but after 20 days developed life-threatening toxic epidermal necrolysis (TEN). To the best of our knowledge this is the first case of TEN in a patient with PMF under thalidomide therapy...
  30. ncbi request reprint Treating two concurrent B-cell and T-cell lymphoid neoplasms with alemtuzumab monotherapy
    Niccolò Bolli
    Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Section, University of Perugia, Italy
    Lancet Oncol 5:64-5. 2004