F Di Virgilio

Summary

Affiliation: University of Ferrara
Country: Italy

Publications

  1. ncbi request reprint Agonists and antagonists acting at P2X7 receptor
    Pier Giovanni Baraldi
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    Curr Top Med Chem 4:1707-17. 2004
  2. pmc Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase
    Patrizia Pellegatti
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Ferrara, Italy
    PLoS ONE 3:e2599. 2008
  3. pmc The P2X7 receptor is a key modulator of aerobic glycolysis
    F Amoroso
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy
    Cell Death Dis 3:e370. 2012
  4. doi request reprint Purines, purinergic receptors, and cancer
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy
    Cancer Res 72:5441-7. 2012
  5. pmc P2 receptors and immunity
    Amel Rayah
    Institut de Biochimie et Biophysique Moleculaire et Cellulaire, CNRS UMR 8619, Universite Paris Sud, 91405 Orsay Cedex, France
    Microbes Infect 14:1254-62. 2012
  6. doi request reprint The therapeutic potential of modifying inflammasomes and NOD-like receptors
    Francesco Di Virgilio
    Department of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy
    Pharmacol Rev 65:872-905. 2013
  7. ncbi request reprint The P2X7 receptor of CLL lymphocytes-a molecule with a split personality
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy
    Lancet 360:1898-9. 2002
  8. ncbi request reprint New pathways for reactive oxygen species generation in inflammation and potential novel pharmacological targets
    F Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation ICSI, University of Ferrara, Via Borsari 46, I 44100, Ferrara, Italy
    Curr Pharm Des 10:1647-52. 2004
  9. ncbi request reprint Liaisons dangereuses: P2X(7) and the inflammasome
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Via Borsari, 46, Ferrara, Italy
    Trends Pharmacol Sci 28:465-72. 2007
  10. pmc Purinergic mechanism in the immune system: A signal of danger for dendritic cells
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation ICSI, University of Ferrara, Ferrara, Italy
    Purinergic Signal 1:205-9. 2005

Collaborators

Detail Information

Publications81

  1. ncbi request reprint Agonists and antagonists acting at P2X7 receptor
    Pier Giovanni Baraldi
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    Curr Top Med Chem 4:1707-17. 2004
    ..Two recent articles published by AstraZeneca have reported that novel series of cyclic imides and adamantane amides are potent P2X(7) receptor antagonists...
  2. pmc Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase
    Patrizia Pellegatti
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Ferrara, Italy
    PLoS ONE 3:e2599. 2008
    ....
  3. pmc The P2X7 receptor is a key modulator of aerobic glycolysis
    F Amoroso
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy
    Cell Death Dis 3:e370. 2012
    ..These data show that the P2X7R has an intrinsic ability to reprogram cell metabolism to meet the needs imposed by adverse environmental conditions...
  4. doi request reprint Purines, purinergic receptors, and cancer
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy
    Cancer Res 72:5441-7. 2012
    ..Investigation of purinergic signaling has increased our understanding of the tumor microenvironment and opened new and exciting avenues for the development of novel therapeutics...
  5. pmc P2 receptors and immunity
    Amel Rayah
    Institut de Biochimie et Biophysique Moleculaire et Cellulaire, CNRS UMR 8619, Universite Paris Sud, 91405 Orsay Cedex, France
    Microbes Infect 14:1254-62. 2012
    ..This makes P2 receptors an attractive target for the therapy of immuno-mediated disease and cancer...
  6. doi request reprint The therapeutic potential of modifying inflammasomes and NOD-like receptors
    Francesco Di Virgilio
    Department of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy
    Pharmacol Rev 65:872-905. 2013
    ..In this review, I will summarize essential features of the known NOD-like receptors, the basic molecular structure of inflammasomes, their participation in pathophysiological responses, and their possible exploitation for therapy...
  7. ncbi request reprint The P2X7 receptor of CLL lymphocytes-a molecule with a split personality
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy
    Lancet 360:1898-9. 2002
  8. ncbi request reprint New pathways for reactive oxygen species generation in inflammation and potential novel pharmacological targets
    F Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation ICSI, University of Ferrara, Via Borsari 46, I 44100, Ferrara, Italy
    Curr Pharm Des 10:1647-52. 2004
    ....
  9. ncbi request reprint Liaisons dangereuses: P2X(7) and the inflammasome
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Via Borsari, 46, Ferrara, Italy
    Trends Pharmacol Sci 28:465-72. 2007
    ....
  10. pmc Purinergic mechanism in the immune system: A signal of danger for dendritic cells
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation ICSI, University of Ferrara, Ferrara, Italy
    Purinergic Signal 1:205-9. 2005
    ..A better knowledge of the modulation of dendritic cell responses by extracellular nucleotides may provide novel routes to enhance the immune response and increase the efficacy of vaccination...
  11. ncbi request reprint Leukocyte P2 receptors: a novel target for anti-inflammatory and anti-tumor therapy
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Italy
    Curr Drug Targets Cardiovasc Haematol Disord 5:85-99. 2005
    ..Importantly, selective blockers of these receptors have been synthesized, thus paving the way to the possible development of P2-targeted anti-inflammatory and anti-tumoral therapies...
  12. pmc P2 receptors: new potential players in atherosclerosis
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, Via Borsari 46, I 44100 Ferrara, Italy
    Br J Pharmacol 135:831-42. 2002
    ..Therefore, we anticipate that a deeper understanding of the involvement of P2 receptors in atheroma formation will open new avenues for drug design and therapeutic intervention...
  13. doi request reprint Purinergic signalling in inflammation of the central nervous system
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, 44100 Ferrara, Italy
    Trends Neurosci 32:79-87. 2009
    ..Likewise, it is clear that purinergic signalling profoundly affects neuroinflammation. Here, we provide a brief update of the state of the art in this expanding field...
  14. pmc P2X(7): a growth-promoting receptor-implications for cancer
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation ICSI, University of Ferrara, Via Borsari 46, Ferrara, 44100, Italy
    Purinergic Signal 5:251-6. 2009
    ..A deeper understanding of the role played by P2X(7) in cell proliferation might provide an insight into the mechanism of normal and malignant cell growth and suggest novel anti-tumour therapies...
  15. doi request reprint Extracellular nucleotides as negative modulators of immunity
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Italy
    Curr Opin Pharmacol 9:507-13. 2009
    ..A deeper understanding of this complex network will no doubt help design more effective therapies for cancer and chronic inflammatory diseases...
  16. pmc Novel data point to a broader mechanism of action of oxidized ATP: the P2X7 receptor is not the only target
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, University of Ferrara, Via Borsari 46, I 44100 Ferrara, Italy
    Br J Pharmacol 140:441-3. 2003
    ..This effect of oATP resembles the action of other natural or synthetic Schiff-base-forming reagents with immunomodulatory activity...
  17. ncbi request reprint The P2 purinergic receptors of human dendritic cells: identification and coupling to cytokine release
    D Ferrari
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Italy
    FASEB J 14:2466-76. 2000
    ..Finally, stimulation of LPS-matured cells with ATP triggered release of IL-1 beta and TNF-alpha. Purinoceptors may provide a new avenue to modulation of dendritic cells function...
  18. ncbi request reprint P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production
    D Ferrari
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Italy
    FEBS Lett 486:217-24. 2000
    ..These events are stimulated or inhibited, respectively, by P2 receptor agonists or antagonists...
  19. ncbi request reprint Cytolytic P2X purinoceptors
    F Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Italy
    Cell Death Differ 5:191-9. 1998
    ..The physiological meaning of P2X receptor-dependent cytotoxicity is not understood, but an involvement in immune-mediated reactions is postulated...
  20. ncbi request reprint Nucleotide receptors: an emerging family of regulatory molecules in blood cells
    F Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology and Medical Genetics, and Center of Biotechnology, University of Ferrara, Ferrara, Italy
    Blood 97:587-600. 2001
    ..However, the cell physiology of these receptors is still at its dawn, and the precise function of the multiple P2X and P2Y receptor subtypes remains to be understood...
  21. pmc Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth
    Elena Adinolfi
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, 44100 Ferrara, Italy
    Mol Biol Cell 16:3260-72. 2005
    ..These findings reveal a hitherto undescribed mechanism for growth stimulation by a plasma membrane pore...
  22. pmc Nimodipine inhibits IL-1β release stimulated by amyloid β from microglia
    J M Sanz
    Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
    Br J Pharmacol 167:1702-11. 2012
    ..In this study, we tested the hypothesis that nimodipine inhibited Aβ-stimulated IL-1β release from microglia...
  23. ncbi request reprint ATP receptors and giant cell formation
    F Di Virgilio
    Department of Experimental and Diagnostic Medicine, and Center of Biotechnology, University of Ferrara, Italy
    J Leukoc Biol 66:723-6. 1999
    ..Our findings suggest that the newly identified purinergic P2X7 receptor plays a central role in the complex chain of events leading to generation of macrophage-derived giant cells...
  24. doi request reprint Activation of microglia by amyloid {beta} requires P2X7 receptor expression
    Juana M Sanz
    Department of Clinical and Experimental Medicine, University of Ferrara, Italy
    J Immunol 182:4378-85. 2009
    ..Identification of the P2X(7) receptor as a non-dispensable factor of Abeta-mediated microglia stimulation may open new avenues for the treatment of Alzheimer disease...
  25. pmc Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells
    Anna Morelli
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, I 44100 Ferrara, Italy
    Mol Biol Cell 14:2655-64. 2003
    ..These observations suggest that P2X7-dependent plasma membrane blebbing depends on the activation of the serine/threonine kinase ROCK I...
  26. ncbi request reprint Increased proliferation rate of lymphoid cells transfected with the P2X(7) ATP receptor
    O R Baricordi
    Section of Medical Genetics, Department of Experimental Medicine, University of Ferrara, I 44100 Ferrara, Italy
    J Biol Chem 274:33206-8. 1999
    ..These data suggest the operation of an ATP-based autocrine/paracrine loop that supports lymphoid cell growth in the absence of serum-derived growth factors...
  27. ncbi request reprint Synthesis of conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor
    P G Baraldi
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Italy
    Bioorg Med Chem Lett 10:681-4. 2000
    ..While KN62 is a potent antagonist of the P2X7 receptor, these analogues were inactive as antagonists and only one compound showed appreciable activity as P2X7 antagonist, which was 30 times weaker than that reported for KN62...
  28. ncbi request reprint Synthesis, biological activity and molecular modeling studies of 1,2,3,4-tetrahydroisoquinoline derivatives as conformationally constrained analogues of KN62, a potent antagonist of the P2X7-receptor containing a tyrosine moiety
    Pier Giovanni Baraldi
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Ferrara, Italy
    Arzneimittelforschung 52:273-85. 2002
    ..A molecular modeling study confirmed that an extended rather than folded conformation seems to be crucial for the antagonistic activity at the P2X7 receptor...
  29. ncbi request reprint Activation of human eosinophils via P2 receptors: novel findings and future perspectives
    Davide Ferrari
    Department of Experimental and Diagnostic Medicine, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Ferrara, Italy
    J Leukoc Biol 79:7-15. 2006
    ..In this review, we will summarize recent developments in this field and put forward a hypothesis about the role of P2 receptors in pathophysiological conditions where eosinophils are major players...
  30. ncbi request reprint A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes
    Giulio Cabrini
    Section of General Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Italy
    J Immunol 175:82-9. 2005
    ..These data identify the 489C>T as a gain-of-function polymorphism of the P2X(7)R...
  31. ncbi request reprint The P2X7 receptor: a key player in IL-1 processing and release
    Davide Ferrari
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Italy
    J Immunol 176:3877-83. 2006
    ....
  32. doi request reprint Extracellular ATP acting at the P2X7 receptor inhibits secretion of soluble HLA-G from human monocytes
    Roberta Rizzo
    Department of Experimental and Diagnostic Medicine, Laboratory of Immunogenetics, Section of Medical Genetics, University of Ferrara, Via L Borsari 46, Ferrara I 44100, Italy
    J Immunol 183:4302-11. 2009
    ..Due to the well-known immunosuppressive activity of IL-10 and soluble HLA-G, this novel effect of ATP might be relevant for the pathophysiology and therapy of inflammatory disorders...
  33. pmc Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis
    Elena Adinolfi
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Via Borsari 46, 44100 Ferrara, Italy
    J Biol Chem 284:10120-8. 2009
    ..e. those observed in response to basal ATP release, has an anti-apoptotic or even growth promoting rather than cytotoxic activity...
  34. doi request reprint Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C2-ceramide and CD95/APO-1/FAS receptor stimulation
    Davide Ferrari
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation and Emilia Romagna Laboratory BioPharmaNet, University of Ferrara, Ferrara, Italy
    Biochem Biophys Res Commun 391:575-81. 2010
    ..e. C(2)-cer mediated) pathway causes an early structural and functional alteration of both ER and mitochondria, thus underlying a final "non return" point in the apoptotic pathway...
  35. ncbi request reprint Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor
    Pier Giovanni Baraldi
    Dipartimento di Scienze Farmaceutiche, Sezione di Patologia Generale, Universita di Ferrara, Italy
    J Med Chem 46:1318-29. 2003
    ..None of the compounds tested on IL-1beta release had any effect on isolated CaMII kinase activity up to 20 microM (not shown)...
  36. ncbi request reprint Calcium and apoptosis: facts and hypotheses
    Rosario Rizzuto
    Department of Experimental and Diagnostic Medicine and Center for the Study of Inflammation, University of Ferrara, Italy
    Oncogene 22:8619-27. 2003
    ....
  37. ncbi request reprint Synthesis, radiolabeling, and preliminary biological evaluation of [3H]-1-[(S)-N,O-bis-(isoquinolinesulfonyl)-N-methyl-tyrosyl]-4-(o-tolyl)-piperazine, a potent antagonist radioligand for the P2X7 receptor
    Romeo Romagnoli
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    Bioorg Med Chem Lett 14:5709-12. 2004
    ..46+/-0.1 nM and 727+/-73 fmol/mg of protein, respectively. The high affinity and facile labeling makes it a promising radioligand for a further characterization of P2X(7) receptor subtype...
  38. pmc A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion
    Patrizia Pellegatti
    Department of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Ferrara 44100, Italy
    Mol Biol Cell 16:3659-65. 2005
    ..This novel approach unveils a hitherto unsuspected nonlytic pathway for the release of large amounts of ATP that might contribute to spreading activation and recruitment of immune cells at inflammatory sites...
  39. ncbi request reprint The antibiotic polymyxin B modulates P2X7 receptor function
    Davide Ferrari
    Department of Experimental and Diagnostic Medicine, Sections of General Pathology, University of Ferrara, Italy
    J Immunol 173:4652-60. 2004
    ....
  40. doi request reprint Purinergic stimulation of human mesenchymal stem cells potentiates their chemotactic response to CXCL12 and increases the homing capacity and production of proinflammatory cytokines
    Davide Ferrari
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Via Borsari 46, Ferrara, Italy
    Exp Hematol 39:360-74, 374.e1-5. 2011
    ..Extracellular adenosine triphosphate (ATP) is a well-recognized mediator of cell-to-cell communication. Here we show ATP effects on bone marrow (BM)-derived human mesenchymal stem cell (hMSCs) functions...
  41. pmc Modulation of P2X7 receptor functions by polymyxin B: crucial role of the hydrophobic tail of the antibiotic molecule
    D Ferrari
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation ICSI, University of Ferrara, Ferrara, Italy
    Br J Pharmacol 150:445-54. 2007
    ..However, the molecular mechanism involved is so far unknown...
  42. ncbi request reprint Stimulation of P2 receptors causes release of IL-1beta-loaded microvesicles from human dendritic cells
    Cinzia Pizzirani
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, I 44100 Ferrara, Italy
    Blood 109:3856-64. 2007
    ....
  43. ncbi request reprint Purinergic signalling between axons and microglia
    Francesco Di Virgilio
    Department of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Italy
    Novartis Found Symp 276:253-8; discussion 259-62, 275-81. 2006
    ....
  44. ncbi request reprint Stimulation of P2 (P2X7) receptors in human dendritic cells induces the release of tissue factor-bearing microparticles
    Marcello Baroni
    Department of Biochemistry, University of Ferrara, Ferrara, Italy
    FASEB J 21:1926-33. 2007
    ..These findings might have implications for triggering and propagating coagulation in healthy and atherosclerotic vessels...
  45. doi request reprint Dysfunctional inflammasome in Schnitzler's syndrome
    Cinzia Pizzirani
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy
    Rheumatology (Oxford) 48:1304-8. 2009
    ..IL-1beta plays a key role in the pathogenesis of Schnitzler's syndrome (SS). We have investigated inflammasome activity in peripheral blood mononuclear cells (PBMCs) from a patient affected by a variant type of SS...
  46. doi request reprint Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor
    Elena Adinolfi
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Via L Borsari 46, 44100, Ferrara, Italy
    FASEB J 24:3393-404. 2010
    ....
  47. ncbi request reprint A defect in glycogen synthesis characterizes insulin resistance in hypertensive patients with type 2 diabetes
    A Solini
    Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
    Hypertension 37:1492-6. 2001
    ....
  48. ncbi request reprint P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia
    Elena Adinolfi
    Department of Experimental and Diagnostic Medicine, Section of Medical Genetics and General Pathology, University of Ferrara, Italy
    Blood 99:706-8. 2002
    ..These results suggest that expression and function of P2X7R may correlate with the severity of B-cell chronic lymphocytic leukemia...
  49. doi request reprint P2X7 receptor drives osteoclast fusion by increasing the extracellular adenosine concentration
    Patrizia Pellegatti
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Ferrara, Italy
    FASEB J 25:1264-74. 2011
    ....
  50. ncbi request reprint Activation of human alveolar macrophages via P2 receptors: coupling to intracellular Ca2+ increases and cytokine secretion
    Daniel Myrtek
    University Hospital Freiburg, Department of Pneumology, Freiburg, Germany
    J Immunol 181:2181-8. 2008
    ..In summary, our data further support the hypothesis that purinoceptors are involved in the pathogenesis of inflammatory lung diseases...
  51. ncbi request reprint Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses
    Marco Idzko
    Department of Experimental Dermatology of Freiburg, D 79104 Freiburg, Germany
    FASEB J 16:625-7. 2002
    ..In summary, our study implicates that S1P might regulate the trafficking of DC and ultimately favor Th2 lymphocyte-dominated immunity...
  52. ncbi request reprint Involvement of the purinergic P2X7 receptor in the formation of multinucleated giant cells
    Irma Lemaire
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Immunol 177:7257-65. 2006
    ..Our study also provides evidence suggesting that stimulation of the P2X7 receptor pathway in MA may mediate increased formation of MGC during chronic inflammatory reactions...
  53. ncbi request reprint Expression and function of histamine receptors in human monocyte-derived dendritic cells
    Marco Idzko
    Department of Experimental Dermatology, University Hospital, Freiburg, Germany
    J Allergy Clin Immunol 109:839-46. 2002
    ..Histamine is a well-known mediator eliciting different responses in immune and nonimmune cells, but its role in modulating dendritic cell (DC) functions has been marginally investigated...
  54. ncbi request reprint Increased P2X7 receptor expression and function in thyroid papillary cancer: a new potential marker of the disease?
    Anna Solini
    Department of Internal Medicine, University of Pisa, Via Roma 67, I 56100 Pisa, Italy
    Endocrinology 149:389-96. 2008
    ..These data suggest that an enhanced P2X(7)R function might be a feature of human thyroid cancer...
  55. ncbi request reprint The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release
    Marco Idzko
    Department of Pneumology, University of Freiburg, Freiburg, Germany
    J Immunol 172:6011-9. 2004
    ..In summary, our study shows that 5-HT stimulated, in a maturation-dependent manner, different signaling pathways in DC. These data point to a role for 5-HT in regulating the immune response at peripheral sites...
  56. pmc Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils
    Marco Idzko
    Department of Pneumology, University of Freiburg, D 79104 Freiburg i Br, Germany
    Br J Pharmacol 138:1244-50. 2003
    ....
  57. ncbi request reprint Defective P2Y purinergic receptor function: A possible novel mechanism for impaired glucose transport
    Anna Solini
    Department of Internal Medicine, University of Pisa, Italy
    J Cell Physiol 197:435-44. 2003
    ..Our observations may point to additional therapeutic targets for improving glucose utilization in diabetes...
  58. ncbi request reprint Alerting and tuning the immune response by extracellular nucleotides
    Andrea la Sala
    Immune Cell Interaction Unit, Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Leukoc Biol 73:339-43. 2003
    ..Chronic exposure to low-dose nucleotides can redirect cellular responses to prototypic activation stimuli, leading to suppressed inflammation and immune deviation...
  59. ncbi request reprint Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes
    Anna Solini
    Department of Internal Medicine, University of Pisa, Italy
    Arterioscler Thromb Vasc Biol 24:1240-5. 2004
    ..We have investigated expression and function of the P2X7 receptor in fibroblasts from healthy subjects and patients with type 2 diabetes...
  60. ncbi request reprint Extracellular adenosine 5'-triphosphate modulates interleukin-6 production by human thyrocytes through functional purinergic P2 receptors
    Nadia Caraccio
    Department of Internal Medicine, University of Pisa, Via Roma 67, I 56100 Pisa Italy
    Endocrinology 146:3172-8. 2005
    ..P2R-dependent modulation of IL-6 release from human thyrocytes suggests a novel mechanism whereby an inflammatory and/or immune-mediated damage can be initiated and amplified in the thyroid...
  61. ncbi request reprint Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control
    Valentina Resta
    Istituto di Neuroscienze CNR 56100 Pisa, Italy
    Development 132:2873-82. 2005
    ..ATP-induced death eliminates cholinergic cells too close to one another, thereby controlling the total number, the local density and the regular spacing of these neurons...
  62. ncbi request reprint Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors
    Marco Idzko
    Department of Experimental Dermatology, University of Freiburg, Germany
    Blood 100:925-32. 2002
    ....
  63. ncbi request reprint A role for P2X7 in microglial proliferation
    Fabio Bianco
    CNR Institute of Neuroscience, Milan, Italy
    J Neurochem 99:745-58. 2006
    ..Overall, our data show that the P2X(7) receptor plays an important role in controlling microglial proliferation by supporting cell cycle progression...
  64. ncbi request reprint Stimulation of purinergic receptors modulates chemokine expression in human keratinocytes
    Saveria Pastore
    Laboratory of Tissue Engineering and Cutaneous Physiopathology, Istituto Dermopatico dell Immacolata, IRCCS, Roma, Italy
    J Invest Dermatol 127:660-7. 2007
    ..Collectively, our data suggest that the orchestrated activation of distinct P2Y and P2X receptors modulates skin inflammation...
  65. ncbi request reprint Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
    Marco Idzko
    Department of Pulmonary Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, P O Box 1738, 3000 DR Rotterdan, The Netherlands
    Nat Med 13:913-9. 2007
    ..Together these data show that purinergic signaling has a key role in allergen-driven lung inflammation that is likely to be amenable to therapeutic intervention...
  66. ncbi request reprint P2X(7) purinergic receptors and extracellular ATP mediate apoptosis of human monocytes/macrophages infected with Mycobacterium tuberculosis reducing the intracellular bacterial viability
    Roberta Placido
    Neuroimmunology Unit, European Centre for Brain Research, S Lucia Foundation, I R C C S, Rome, Italy
    Cell Immunol 244:10-8. 2006
    ....
  67. ncbi request reprint The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration
    Lara Rossi
    Institute of Hematology and Medical Oncology L and A Seragnoli, University of Bologna, and Stem Cell Research Center, S Orsola Malpighi Hospital, Italy
    Blood 109:533-42. 2007
    ..Our data suggest that UTP may physiologically modulate the homing of HSCs to the BM, in concert with CXCL12, via the activation of converging signaling pathways between CXCR4 and P2Y receptors, involving Galphai proteins and RhoGTPases...
  68. ncbi request reprint Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors
    Elena Adinolfi
    Institute of Molecular Physiology, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom
    J Biol Chem 278:37344-51. 2003
    ..We conclude that selective tyrosine phosphorylation of P2X7 receptor-associated HSP90 may act as a negative regulator of P2X7 receptor complex formation and function...
  69. pmc Increased sensitivity to extracellular ATP of fibroblasts from patients affected by systemic sclerosis
    Andrea Lo Monaco
    Ann Rheum Dis 66:1124-5. 2007
  70. ncbi request reprint Extracellular ATP induces cell death in CD4+/CD8+ double-positive thymocytes in mice infected with Trypanosoma cruzi
    Marcio Mantuano-Barradas
    Laboratório de Imunobiofísica, Instituto de Biofisica Carlos Chagas Filho, UFRJ, Bloco G do CCS, Cidade Universitaria, Ilha do Fundao, 21941 590 Rio de Janeiro, Brazil
    Microbes Infect 5:1363-71. 2003
    ..No differences were observed prior to the atrophy phase or during the chronic phase. Our results indicate that P2Z/P2X7 receptors may play a central role in thymus atrophy during T. cruzi infection...
  71. ncbi request reprint Acute retinal ganglion cell injury caused by intraocular pressure spikes is mediated by endogenous extracellular ATP
    Valentina Resta
    Istituto di Neuroscienze CNR, Pisa, Italy
    Eur J Neurosci 25:2741-54. 2007
    ..These data show that rapid pressure transients induce acute ganglion cell injury and unveil the causal role of extracellular ATP elevation in such injury...
  72. ncbi request reprint A role for calcium in Bcl-2 action?
    Paolo Pinton
    Department of Biomedical Sciences and CNR Center for the Study of Biomembranes, University of Padova, Via Colombo 3, 35121 Padova, Italy
    Biochimie 84:195-201. 2002
    ..In this contribution, we will discuss this effect and its significance for the mechanism of action of Bcl-2, an important checkpoint of the apoptotic process...
  73. ncbi request reprint Purinergic modulation of mesangial extracellular matrix production: role in diabetic and other glomerular diseases
    Anna Solini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Kidney Int 67:875-85. 2005
    ....
  74. ncbi request reprint The influence of lysophosphatidic acid on the functions of human dendritic cells
    Elisabeth Panther
    Department of Experimental Dermatology, University of Freiburg, Hauptstrasse 7, D 79104 Freiburg i Br, Germany
    J Immunol 169:4129-35. 2002
    ..In summary, our study implicates that LPA might regulate the trafficking, cytokine production, and T cell-activating functions of DCs...
  75. ncbi request reprint 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes
    Thorsten Dürk
    Department of Pneumology, University Medical Clinic, University of Freiburg, Germany
    Int Immunol 17:599-606. 2005
    ..Our results point to a new role for 5-HT in inflammation by modulating cytokine production in monocytes via activation of 5-HTR(3), 5-HTR(4) and 5-HTR(7) subtypes...
  76. ncbi request reprint The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion
    Tobias Müller
    Department of Pneumology, University Medical Clinic, University of Freiburg, D 79104 Freiburg i Br, Germany
    Am J Respir Cell Mol Biol 33:601-9. 2005
    ..In addition, UDP-glc did not affect proliferation of the two cell lines. In summary, our data provide evidence for a distinct physiologic role of P2Y(14) in the selective release of specific chemokines from human airway epithelial cells...
  77. ncbi request reprint The P2X7 receptor sustains the growth of human neuroblastoma cells through a substance P-dependent mechanism
    Lizzia Raffaghello
    Laboratory of Oncology, Giannina Gaslini Institute, Largo Gerolamo Gaslini 5, Genoa, Italy 16147
    Cancer Res 66:907-14. 2006
    ..Therefore, neuroblastoma cells seem to have molded P2X(7) function to their advantage in two ways (i.e., by silencing P2X(7) proapoptotic activity and by coupling P2X(7) stimulation to release of locally acting trophic factors)...
  78. ncbi request reprint Dendritic cells exposed to extracellular adenosine triphosphate acquire the migratory properties of mature cells and show a reduced capacity to attract type 1 T lymphocytes
    Andrea la Sala
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    Blood 99:1715-22. 2002
    ..Our data suggest that ATP provides a signal for enhanced lymph node localization of DCs but that it may, at the same time, diminish the capacity of DCs to amplify type 1 immune responses...
  79. ncbi request reprint Extracellular nucleotides are potent stimulators of human hematopoietic stem cells in vitro and in vivo
    Roberto M Lemoli
    Institute of Hematology and Medical Oncology L and A Seragnoli, University of Bologna, Italy
    Blood 104:1662-70. 2004
    ..Our data suggest that extracellular nucleotides may provide a novel and powerful tool to modulate HSC functions...