Antonio Di Sabatino

Summary

Affiliation: University of Pavia
Location: Pavia, Italy
Summary:
Dr. Antonio Di Sabatino is Senior Lecturer in Gastroenterology at the School of Medicine, University of Pavia (Italy, and he performs clinical activity at the First Department of Medicine, S. Matteo Hospital in Pavia. His scientific research has focused on gastroenterology with special reference to the immune pathogenesis of celiac disease and inflammatory bowel diseases, and in particular on how inappropriate immune reactions cause disease in the human gut.

Publications:
1: Di Sabatino A, Rovedatti L, Vidali F, Macdonald TT, Corazza GR. Recent advances in understanding Crohns disease. Intern Emerg Med. 2011 May 8. [Epub
ahead of print] PubMed PMID: .


2: Di Sabatino A, Brunetti L, Biancheri P, Ciccocioppo R, Guerci M, Casella C,Vidali F, Macdonald TT, Benazzo M, Corazza GR. Mucosal changes induced by ischemia-reperfusion injury in a jejunal loop transplanted in oropharynx. Intern
Emerg Med. 2011 May 8. [Epub ahead of print] PubMed PMID: .


3: Di Sabatino A, Paccagnini D, Vidali F, Rosu V, Biancheri P, Cossu A, Zanetti
S, Corazza GR, Sechi LA. Detection of Mycobacterium avium subsp. paratuberculosis
(MAP)-specific IS900 DNA and antibodies against MAP peptides and lysate in the
blood of Crohns disease patients. Inflamm Bowel Dis. 2011 May;17(5):1254-5. doi:
10.1002/ibd.21461. Epub 2010 Sep 2. PubMed PMID: .


4: Rovedatti L, Di Sabatino A, Knowles CH, Sengupta N, Biancheri P, Corazza GR,
Macdonald TT. Fibroblast activation protein expression in Crohns disease
strictures. Inflamm Bowel Dis. 2011 May;17(5):1251-3. doi: 10.1002/ibd.21446.
Epub 2010 Aug 30. PubMed PMID: .


5: De Leo V, Musacchio MC, Piomboni P, Di Sabatino A, Morgante G. The
administration of metformin during pregnancy reduces polycystic ovary syndrome
related gestational complications. Eur J Obstet Gynecol Reprod Biol. 2011 Apr 27.
[Epub ahead of print] PubMed PMID: .


6: Di Sabatino A, Biancheri P, Rovedatti L, Macdonald TT, Corazza GR. New
pathogenic paradigms in inflammatory bowel disease. Inflamm Bowel Dis. 2011 Apr
27. doi: 10.1002/ibd.21735. [Epub ahead of print] PubMed PMID: .


7: Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G,
Vanoli A, Dainese E, Guerci M, Piomelli D, Pender SL, Macdonald TT, Maccarrone M,
Corazza GR. The endogenous cannabinoid system in the gut of patients with
inflammatory bowel disease. Mucosal Immunol. 2011 Apr 6. [Epub ahead of print]
PubMed PMID: .


8: Di Sabatino A, Carsetti R, Corazza GR. Post-splenectomy and hyposplenic
states. Lancet. 2011 Apr 5. [Epub ahead of print] PubMed PMID: .


9: Di Sabatino A, Rovedatti L, Vetrano S, Vidali F, Biancheri P, Rescigno M,
Danese S, Macdonald TT, Corazza GR. Involvement of CD40-CD40 ligand in
uncomplicated and refractory celiac disease. Am J Gastroenterol. 2011
Mar;106(3):519-27. Epub 2010 Dec 7. PubMed PMID: .


10: Fina D, Franz? E, Rovedatti L, Corazza GR, Biancone L, Sileri PP, Sica G,
MacDonald TT, Pallone F, Di Sabatino A, Monteleone G. Interleukin-25 production
is differently regulated by TNF-α and TGF-β1 in the human gut. Mucosal Immunol.
2011 Mar;4(2):239-44. Epub 2010 Oct 13. PubMed PMID: .


11: Morgante G, Orvieto R, Di Sabatino A, Musacchio MC, De Leo V. The role of
inositol supplementation in patients with polycystic ovary syndrome, with insulin
resistance, undergoing the low-dose gonadotropin ovulation induction regimen.
Fertil Steril. 2011 Feb 5. [Epub ahead of print] PubMed PMID: .


12: Di Sabatino A, Calarota SA, Vidali F, Macdonald TT, Corazza GR. Role of IL-15
in immune-mediated and infectious diseases. Cytokine Growth Factor Rev. 2011
Feb;22(1):19-33. Epub 2010 Nov 11. PubMed PMID: .


13: Papadia C, Kelly P, Caini S, Corazza GR, Shawa T, Franz? A, Forbes A, Di
Sabatino A. Plasma citrulline as a quantitative biomarker of HIV-associated
villous atrophy in a tropical enteropathy population. Clin Nutr. 2010
Dec;29(6):795-800. Epub 2010 Jun 19. PubMed PMID: .


14: Di Sabatino A, Biancheri P, Piconese S, Rosado MM, Ardizzone S, Rovedatti L,
Ubezio C, Massari A, Sampietro GM, Foschi D, Porro GB, Colombo MP, Carsetti R,
MacDonald TT, Corazza GR. Peripheral regulatory T cells and serum transforming
growth factor-β: relationship with clinical response to infliximab in Crohns
disease. Inflamm Bowel Dis. 2010 Nov;16(11):1891-7. PubMed PMID: .


15: Docena G, Rovedatti L, Kruidenier L, Fanning A, Leakey NA, Knowles CH, Lee K,
Shanahan F, Nally K, McLean PG, Di Sabatino A, MacDonald TT. Down-regulation of
p38 mitogen-activated protein kinase activation and proinflammatory cytokine
production by mitogen-activated protein kinase inhibitors in inflammatory bowel
disease. Clin Exp Immunol. 2010 Oct;162(1):108-15. doi:
10.1111/j.1365-2249.2010.04203.x. Epub 2010 Aug 20. PubMed PMID: ; PubMed
Central PMCID: PMC2990936.


16: De Leo V, Di Sabatino A, Musacchio MC, Morgante G, Scolaro V, Cianci A,
Petraglia F. Effect of oral contraceptives on markers of hyperandrogenism and
SHBG in women with polycystic ovary syndrome. Contraception. 2010
Sep;82(3):276-80. Epub 2010 Jul 16. PubMed PMID: .


17: Morgante G, Scolaro V, Tosti C, Di Sabatino A, Piomboni P, De Leo V.
[Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves
sperm motility and sexual health in men with asthenopermia]. Minerva Urol Nefrol.
2010 Sep;62(3):213-8. Italian. PubMed PMID: .


18: Vidali F, Di Sabatino A, Broglia F, Cazzola P, Biancheri P, Viera FT, Vanoli
A, Alvisi C, Perego M, Corazza GR. Increased CD8+ intraepithelial lymphocyte
infiltration and reduced surface area to volume ratio in the duodenum of patients
with ulcerative colitis. Scand J Gastroenterol. 2010 Jun;45(6):684-9. PubMed
PMID: .


19: Bergamaschi G, Di Sabatino A, Albertini R, Ardizzone S, Biancheri P, Bonetti
E, Cassinotti A, Cazzola P, Markopoulos K, Massari A, Rosti V, Porro GB, Corazza
GR. Prevalence and pathogenesis of anemia in inflammatory bowel disease.
Influence of anti-tumor necrosis factor-alpha treatment. Haematologica. 2010
Feb;95(2):199-205. Epub 2009 Oct 8. PubMed PMID: ; PubMed Central PMCID:
PMC2817021.


20: Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles CH, Rampton DS, Corazza
GR, Monteleone G, Di Sabatino A, Macdonald TT. Differential regulation of
interleukin 17 and interferon gamma production in inflammatory bowel disease.
Gut. 2009 Dec;58(12):1629-36. Epub 2009 Sep 8. PubMed PMID: .


21: MacDonald TT, Di Sabatino A. The immunologic basis for gastrointestinal food
allergy. Curr Opin Gastroenterol. 2009 Nov;25(6):521-6. Review. PubMed PMID:
.


22: Di Sabatino A, Vidali F, Cazzola P, Marchese A, Biancheri P, Biagi F, Corazza
GR. Splenic hypofunction in Whipples disease. Am J Gastroenterol. 2009
Oct;104(10):2641-3. PubMed PMID: .


23: De Leo V, Musacchio MC, Palermo V, Di Sabatino A, Morgante G, Petraglia F.
Polycystic ovary syndrome and metabolic comorbidities: therapeutic options. Drugs
Today (Barc). 2009 Oct;45(10):763-75. Review. PubMed PMID: .


24: Di Sabatino A, Saarialho-Kere U, Buckley MG, Gordon JN, Biancheri P,
Rovedatti L, Corazza GR, Macdonald TT, Pender SL. Stromelysin-1 and macrophage
metalloelastase expression in the intestinal mucosa of Crohns disease patients
treated with infliximab. Eur J Gastroenterol Hepatol. 2009 Sep;21(9):1049-55.
PubMed PMID: .


25: Rescigno M, Di Sabatino A. Dendritic cells in intestinal homeostasis and
disease. J Clin Invest. 2009 Sep;119(9):2441-50. doi: 10.1172/JCI39134. Epub 2009
Sep 1. Review. PubMed PMID: ; PubMed Central PMCID: PMC2735931.


26: Gordon JN, Prothero JD, Thornton CA, Pickard KM, Di Sabatino A, Goggin PM,
Pender SL, Macdonald TT. CC-10004 but not thalidomide or lenalidomide inhibits
lamina propria mononuclear cell TNF-α and MMP-3 production in patients with
inflammatory bowel disease. J Crohns Colitis. 2009 Sep;3(3):175-82. Epub 2009 Apr
10. PubMed PMID: .


27: Di Sabatino A, Rovedatti L, Kaur R, Spencer JP, Brown JT, Morisset VD,
Biancheri P, Leakey NA, Wilde JI, Scott L, Corazza GR, Lee K, Sengupta N, Knowles
CH, Gunthorpe MJ, McLean PG, MacDonald TT, Kruidenier L. Targeting gut T cell
Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and
T-box transcription factor T-bet in inflammatory bowel disease. J Immunol. 2009
Sep 1;183(5):3454-62. Epub 2009 Jul 31. PubMed PMID: .


28: MacDonald TT, Vossenkamper A, Di Sabatino A. Antigen presenting cells and T
cell interactions in the gastrointestinal tract. Mol Nutr Food Res. 2009
Aug;53(8):947-51. Review. Erratum in: Mol Nutr Food Res. 2009 Oct;53(10):1352.
Voessenkamper, Anna [corrected to Vossenkamper, Anna]. PubMed PMID: .


29: Di Sabatino A, Jackson CL, Pickard KM, Buckley M, Rovedatti L, Leakey NA,
Picariello L, Cazzola P, Monteleone G, Tonelli F, Corazza GR, MacDonald TT,
Pender SL. Transforming growth factor beta signalling and matrix
metalloproteinases in the mucosa overlying Crohns disease strictures. Gut. 2009
Jun;58(6):777-89. Epub 2009 Feb 6. PubMed PMID: .


30: Di Sabatino A, Rovedatti L, Rosado MM, Carsetti R, Corazza GR, MacDonald TT.
Increased expression of mucosal addressin cell adhesion molecule 1 in the
duodenum of patients with active celiac disease is associated with depletion of
integrin alpha4beta7-positive T cells in blood. Hum Pathol. 2009
May;40(5):699-704. Epub 2009 Jan 20. PubMed PMID: .


31: Di Sabatino A, Corazza GR. Coeliac disease. Lancet. 2009 Apr
25;373(9673):1480-93. PubMed PMID: .


32: Bergamaschi G, Markopoulos K, Albertini R, Di Sabatino A, Biagi F,
Ciccocioppo R, Arbustini E, Corazza GR. Anemia of chronic disease and defective
erythropoietin production in patients with celiac disease. Haematologica. 2008
Dec;93(12):1785-91. Epub 2008 Sep 24. PubMed PMID: .


33: Di Sabatino A, Miceli E, Dhaliwal W, Biancheri P, Salerno R, Cantoro L,
Vanoli A, De Vincenzi M, Blanco Cdel V, MacDonald TT, Corazza GR. Distribution,
proliferation, and function of Paneth cells in uncomplicated and complicated
adult celiac disease. Am J Clin Pathol. 2008 Jul;130(1):34-42. PubMed PMID:
.


34: Di Sabatino A, Pickard KM, Rampton D, Kruidenier L, Rovedatti L, Leakey NA,
Corazza GR, Monteleone G, MacDonald TT. Blockade of transforming growth factor
beta upregulates T-box transcription factor T-bet, and increases T helper cell
type 1 cytokine and matrix metalloproteinase-3 production in the human gut
mucosa. Gut. 2008 May;57(5):605-12. Epub 2008 Jan 4. PubMed PMID: .


35: Di Sabatino A, Rosado MM, Cazzola P, Biancheri P, Tinozzi FP, Laera MR,
Cantoro L, Vanoli A, Carsetti R, Corazza GR. Splenic function and IgM-memory B
cells in Crohns disease patients treated with infliximab. Inflamm Bowel Dis.
2008 May;14(5):591-6. PubMed PMID: .


36: Gordon JN, Pickard KM, Di Sabatino A, Prothero JD, Pender SL, Goggin PM,
MacDonald TT. Matrix metalloproteinase-3 production by gut IgG plasma cells in
chronic inflammatory bowel disease. Inflamm Bowel Dis. 2008 Feb;14(2):195-203.
PubMed PMID: .


37: Di Sabatino A, Rosado MM, Miele L, Capolunghi F, Cazzola P, Biancheri P,
Carsetti R, Gasbarrini G, Corazza GR. Impairment of splenic IgM-memory but not
switched-memory B cells in a patient with celiac disease and splenic atrophy. J
Allergy Clin Immunol. 2007 Dec;120(6):1461-3. Epub 2007 Sep 24. PubMed PMID:
.


38: Di Sabatino A, Pickard KM, Gordon JN, Salvati V, Mazzarella G, Beattie RM,
Vossenkaemper A, Rovedatti L, Leakey NA, Croft NM, Troncone R, Corazza GR, Stagg
AJ, Monteleone G, MacDonald TT. Evidence for the role of interferon-alfa
production by dendritic cells in the Th1 response in celiac disease.
Gastroenterology. 2007 Oct;133(4):1175-87. Epub 2007 Aug 14. PubMed PMID:
.


39: Di Sabatino A, Pender SL, Jackson CL, Prothero JD, Gordon JN, Picariello L,
Rovedatti L, Docena G, Monteleone G, Rampton DS, Tonelli F, Corazza GR, MacDonald
TT. Functional modulation of Crohns disease myofibroblasts by anti-tumor
necrosis factor antibodies. Gastroenterology. 2007 Jul;133(1):137-49. Epub 2007
May 5. PubMed PMID: .


40: Colombo PL, Benedetti M, Tinozzi FP, Ticozzelli E, Maroni N, Di Sabatino A,
Tinozzi S. [Different approaches for medical or surgical management of Crohns
disease: the importance of the classification of Vienna]. Ann Ital Chir. 2006
Nov-Dec;77(6):485-96. Review. Italian. PubMed PMID: .


41: Pender SL, Li CK, Di Sabatino A, MacDonald TT, Buckley MG. Role of macrophage
metalloelastase in gut inflammation. Ann N Y Acad Sci. 2006 Aug;1072:386-8.
Erratum in: Ann N Y Acad Sci. 2008 Apr;1126:333. Sabatino, A D I [corrected to Di
Sabatino, A]. PubMed PMID: .


42: MacDonald TT, Di Sabatino A. The exposure of infants to Lactobacillus
rhamnosus GG in Finland. J Pediatr Gastroenterol Nutr. 2006 May;42(5):476-8.
PubMed PMID: .


43: Ciccocioppo R, Finamore A, Ara C, Di Sabatino A, Mengheri E, Corazza GR.
Altered expression, localization, and phosphorylation of epithelial junctional
proteins in celiac disease. Am J Clin Pathol. 2006 Apr;125(4):502-11. PubMed
PMID: .


44: Di Sabatino A, Ciccocioppo R, Cupelli F, Cinque B, Millimaggi D, Clarkson MM,
Paulli M, Cifone MG, Corazza GR. Epithelium derived interleukin 15 regulates
intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in
coeliac disease. Gut. 2006 Apr;55(4):469-77. Epub 2005 Aug 16. PubMed PMID:
; PubMed Central PMCID: PMC1856172.


45: Di Sabatino A, Rosado MM, Cazzola P, Riboni R, Biagi F, Carsetti R, Corazza
GR. Splenic hypofunction and the spectrum of autoimmune and malignant
complications in celiac disease. Clin Gastroenterol Hepatol. 2006
Feb;4(2):179-86. PubMed PMID: .


46: Di Sabatino A, Morera R, Ciccocioppo R, Cazzola P, Gotti S, Tinozzi FP,
Tinozzi S, Corazza GR. Oral butyrate for mildly to moderately active Crohns
disease. Aliment Pharmacol Ther. 2005 Nov 1;22(9):789-94. PubMed PMID: .


47: Maconi G, Di Sabatino A, Ardizzone S, Greco S, Colombo E, Russo A, Cassinotti
A, Casini V, Corazza GR, Bianchi Porro G. Prevalence and clinical significance of
sonographic detection of enlarged regional lymph nodes in Crohns disease. Scand
J Gastroenterol. 2005 Nov;40(11):1328-33. PubMed PMID: .


48: Di Sabatino A, Rosado MM, Ciccocioppo R, Cazzola P, Morera R, Corazza GR,
Carsetti R. Depletion of immunoglobulin M memory B cells is associated with
splenic hypofunction in inflammatory bowel disease. Am J Gastroenterol. 2005
Aug;100(8):1788-95. PubMed PMID: .


49: Gordon JN, Di Sabatino A, Macdonald TT. The pathophysiologic rationale for
biological therapies in inflammatory bowel disease. Curr Opin Gastroenterol. 2005
Jul;21(4):431-7. Review. PubMed PMID: .


50: MacDonald TT, Di Sabatino A, Gordon JN. Immunopathogenesis of Crohns
disease. JPEN J Parenter Enteral Nutr. 2005 Jul-Aug;29(4 Suppl):S118-24;
discussion S124-5, S184-8. Review. Erratum in: JPEN J Parenter Enteral Nutr. 2006
Jan-Feb;30(1):table of contents. DiSabatino, Antonio [corrected to Di Sabatino,
Antonio]. PubMed PMID: .


51: Ciccocioppo R, Di Sabatino A, Corazza GR. The immune recognition of gluten in
coeliac disease. Clin Exp Immunol. 2005 Jun;140(3):408-16. Review. PubMed PMID:
; PubMed Central PMCID: PMC1809391.


52: Ciccocioppo R, Di Sabatino A, Bauer M, Della Riccia DN, Bizzini F, Biagi F,
Cifone MG, Corazza GR, Schuppan D. Matrix metalloproteinase pattern in celiac
duodenal mucosa. Lab Invest. 2005 Mar;85(3):397-407. PubMed PMID: .


53: Di Sabatino A, Carsetti R, Rosado MM, Ciccocioppo R, Cazzola P, Morera R,
Tinozzi FP, Tinozzi S, Corazza GR. Immunoglobulin M memory B cell decrease in
inflammatory bowel disease. Eur Rev Med Pharmacol Sci. 2004 Sep-Oct;8(5):199-203.
PubMed PMID: .


54: Di Sabatino A, Ciccocioppo R, Armellini E, Morera R, Ricevuti L, Cazzola P,
Fulle I, Corazza GR. Serum bFGF and VEGF correlate respectively with bowel wall
thickness and intramural blood flow in Crohns disease. Inflamm Bowel Dis. 2004
Sep;10(5):573-7. PubMed PMID: .


55: Di Sabatino A, Ciccocioppo R, Benazzato L, Sturniolo GC, Corazza GR.
Infliximab downregulates basic fibroblast growth factor and vascular endothelial
growth factor in Crohns disease patients. Aliment Pharmacol Ther. 2004 May
1;19(9):1019-24. PubMed PMID: .


56: Di Sabatino A, Armellini E, Corazza GR. Doppler sonography in the diagnosis
of inflammatory bowel disease. Dig Dis. 2004;22(1):63-6. Review. PubMed PMID:
.


57: Di Sabatino A, Boggero A, Miccoli FP, Cicolani B. Diversity, distribution and
ecology of water mites (Acari: Hydrachnidia and Halacaridae) in high Alpine lakes
(Central Alps, Italy). Exp Appl Acarol. 2004;34(1-2):199-210. PubMed PMID:
.


58: Di Sabatino A, Ciccocioppo R, Cinque B, Millimaggi D, Morera R, Ricevuti L,
Cifone MG, Corazza GR. Defective mucosal T cell death is sustainably reverted by
infliximab in a caspase dependent pathway in Crohns disease. Gut. 2004
Jan;53(1):70-7. PubMed PMID: ; PubMed Central PMCID: PMC1773915.


59: Ciccocioppo R, Di Sabatino A, Ara C, Biagi F, Perilli M, Amicosante G, Cifone
MG, Corazza GR. Gliadin and tissue transglutaminase complexes in normal and
coeliac duodenal mucosa. Clin Exp Immunol. 2003 Dec;134(3):516-24. PubMed PMID:
; PubMed Central PMCID: PMC1808891.


60: Di Sabatino A, Ciccocioppo R, Luinetti O, Ricevuti L, Morera R, Cifone MG,
Solcia E, Corazza GR. Increased enterocyte apoptosis in inflamed areas of Crohns
disease. Dis Colon Rectum. 2003 Nov;46(11):1498-507. PubMed PMID: .


61: Martucci S, Biagi F, Di Sabatino A, Corazza GR. Coeliac disease. Dig Liver
Dis. 2002 Sep;34 Suppl 2:S150-3. Review. PubMed PMID: .


62: Ciccocioppo R, Di Sabatino A, Luinetti O, Rossi M, Cifone MG, Corazza GR.
Small bowel enterocyte apoptosis and proliferation are increased in the elderly.
Gerontology. 2002 Jul-Aug;48(4):204-8. PubMed PMID: .


63: Di Sabatino A, Fulle I, Ciccocioppo R, Ricevuti L, Tinozzi FP, Tinozzi S,
Campani R, Corazza GR. Doppler enhancement after intravenous levovist injection
in Crohns disease. Inflamm Bowel Dis. 2002 Jul;8(4):251-7. PubMed PMID:
.


64: Ciccocioppo R, DAlo S, Di Sabatino A, Parroni R, Rossi M, Doglioni C, Cifone
MG, Corazza GR. Mechanisms of villous atrophy in autoimmune enteropathy and
coeliac disease. Clin Exp Immunol. 2002 Apr;128(1):88-93. PubMed PMID: ;
PubMed Central PMCID: PMC1906355.


65: Di Sabatino A, Ciccocioppo R, DAl? S, Parroni R, Millimaggi D, Cifone MG,
Corazza GR. Intraepithelial and lamina propria lymphocytes show distinct patterns
of apoptosis whereas both populations are active in Fas based cytotoxicity in
coeliac disease. Gut. 2001 Sep;49(3):380-6. PubMed PMID: ; PubMed Central
PMCID: PMC1728419.


66: Di Sabatino A, DAl? S, Millimaggi D, Ciccocioppo R, Parroni R, Sciarra G,
Cifone MG, Corazza GR. Apoptosis and peripheral blood lymphocyte depletion in
coeliac disease. Immunology. 2001 Aug;103(4):435-40. PubMed PMID: ;
PubMed Central PMCID: PMC1783265.


67: Di Sabatino A, Corazza GR. Surviving too long in Crohns disease. Gut. 2001
Jul;49(1):6-8. PubMed PMID: ; PubMed Central PMCID: PMC1728362.


68: Ciccocioppo R, Di Sabatino A, Parroni R, Muzi P, DAl? S, Ventura T, Pistoia
MA, Cifone MG, Corazza GR. Increased enterocyte apoptosis and Fas-Fas ligand
system in celiac disease. Am J Clin Pathol. 2001 Apr;115(4):494-503. PubMed PMID:
.


69: Ciccocioppo R, Di Sabatino A, Parroni R, Dal? S, Pistoia MA, Doglioni C,
Cifone MG, Corazza GR. Cytolytic mechanisms of intraepithelial lymphocytes in
coeliac disease (CoD). Clin Exp Immunol. 2000 May;120(2):235-40. PubMed PMID:
; PubMed Central PMCID: PMC1905653.


70: Ciccocioppo R, Di Sabatino A, Gasbarrini G, Corazza GR. Apoptosis and
gastrointestinal tract. Ital J Gastroenterol Hepatol. 1999 Mar;31(2):162-72.
Review. PubMed PMID: .


71: Corazza GR, Zoli G, Di Sabatino A, Ciccocioppo R, Gasbarrini G. A
reassessment of splenic hypofunction in celiac disease. Am J Gastroenterol. 1999
Feb;94(2):391-7. PubMed PMID: .


72: Di Sabatino A, Bertrandi E, Casadei Maldini M, Pennese F, Proietti F, Corazza
GR. Phenotyping of peripheral blood lymphocytes in adult coeliac disease.
Immunology. 1998 Dec;95(4):572-6. PubMed PMID: 9893047; PubMed Central PMCID:
PMC1364354.

Publications

  1. Di Sabatino A, Vidali F, Cazzola P, Marchese A, Biancheri P, Biagi F, et al. Splenic hypofunction in Whipple's disease. Am J Gastroenterol. 2009;104:2641-3 pubmed publisher
  2. Ciccocioppo R, Di Sabatino A, Gasbarrini G, Corazza G. Apoptosis and gastrointestinal tract. Ital J Gastroenterol Hepatol. 1999;31:162-72 pubmed
    ..This review will deal with the mechanisms potentially involved in apoptosis and with the clinical relevance of this phenomenon in gastrointestinal diseases. ..
  3. Pender S, Li C, Di Sabatino A, Sabatino A, MacDonald T, Buckley M. Role of macrophage metalloelastase in gut inflammation. Ann N Y Acad Sci. 2006;1072:386-8 pubmed
    ..We have shown that MMP-3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP-12 in these idiopathic diseases. ..
  4. Di Sabatino A, D Alò S, Millimaggi D, Ciccocioppo R, Parroni R, Sciarra G, et al. Apoptosis and peripheral blood lymphocyte depletion in coeliac disease. Immunology. 2001;103:435-40 pubmed
    ..This increased apoptosis could be responsible for both lymphopenia and immunogenic exposure of phospholipids with subsequent production of autoantibodies. ..
  5. Fina D, Franzè E, Rovedatti L, Corazza G, Biancone L, Sileri P, et al. Interleukin-25 production is differently regulated by TNF-? and TGF-?1 in the human gut. Mucosal Immunol. 2011;4:239-44 pubmed publisher
    ..Knockdown of Smad7 was accompanied by an increase in IL-25 production. Data show that IL-25 production is differently regulated by TNF-? and TGF-?1 in the human gut. ..
  6. Docena G, Rovedatti L, Kruidenier L, Fanning A, Leakey N, Knowles C, et al. Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease. Clin Exp Immunol. 2010;162:108-15 pubmed publisher
    ..Additionally, all the p38? selective inhibitory drugs significantly down-regulated the activation of the MAPK pathway and the secretion of proinflammatory cytokines. ..
  7. Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G, et al. The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease. Mucosal Immunol. 2011;4:574-83 pubmed publisher
    ..Although these results are promising, further studies are needed to determine the role of cannabinoid pathways in gut inflammation. ..
  8. Rovedatti L, Di Sabatino A, Knowles C, Sengupta N, Biancheri P, Corazza G, et al. Fibroblast activation protein expression in Crohn's disease strictures. Inflamm Bowel Dis. 2011;17:1251-3 pubmed publisher
  9. Gordon J, Di Sabatino A, MacDonald T. The pathophysiologic rationale for biological therapies in inflammatory bowel disease. Curr Opin Gastroenterol. 2005;21:431-7 pubmed
    ..Novel approaches, such as exploiting the antiinflammatory role of cannabinoid receptors, may also prove productive in the future. ..
  10. Gordon J, Pickard K, Di Sabatino A, Prothero J, Pender S, Goggin P, et al. Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease. Inflamm Bowel Dis. 2008;14:195-203 pubmed
    ..We have demonstrated that IgG PCs from patients with IBD express large amounts of MMP-3 and that they appear to be long-lived. These results identify a new pathway by which IgG PCs may damage the gut. ..

Locale

Detail Information

Publications63

  1. Di Sabatino A, Vidali F, Cazzola P, Marchese A, Biancheri P, Biagi F, et al. Splenic hypofunction in Whipple's disease. Am J Gastroenterol. 2009;104:2641-3 pubmed publisher
  2. Ciccocioppo R, Di Sabatino A, Gasbarrini G, Corazza G. Apoptosis and gastrointestinal tract. Ital J Gastroenterol Hepatol. 1999;31:162-72 pubmed
    ..This review will deal with the mechanisms potentially involved in apoptosis and with the clinical relevance of this phenomenon in gastrointestinal diseases. ..
  3. Pender S, Li C, Di Sabatino A, Sabatino A, MacDonald T, Buckley M. Role of macrophage metalloelastase in gut inflammation. Ann N Y Acad Sci. 2006;1072:386-8 pubmed
    ..We have shown that MMP-3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP-12 in these idiopathic diseases. ..
  4. Di Sabatino A, D Alò S, Millimaggi D, Ciccocioppo R, Parroni R, Sciarra G, et al. Apoptosis and peripheral blood lymphocyte depletion in coeliac disease. Immunology. 2001;103:435-40 pubmed
    ..This increased apoptosis could be responsible for both lymphopenia and immunogenic exposure of phospholipids with subsequent production of autoantibodies. ..
  5. Fina D, Franzè E, Rovedatti L, Corazza G, Biancone L, Sileri P, et al. Interleukin-25 production is differently regulated by TNF-? and TGF-?1 in the human gut. Mucosal Immunol. 2011;4:239-44 pubmed publisher
    ..Knockdown of Smad7 was accompanied by an increase in IL-25 production. Data show that IL-25 production is differently regulated by TNF-? and TGF-?1 in the human gut. ..
  6. Docena G, Rovedatti L, Kruidenier L, Fanning A, Leakey N, Knowles C, et al. Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease. Clin Exp Immunol. 2010;162:108-15 pubmed publisher
    ..Additionally, all the p38? selective inhibitory drugs significantly down-regulated the activation of the MAPK pathway and the secretion of proinflammatory cytokines. ..
  7. Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G, et al. The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease. Mucosal Immunol. 2011;4:574-83 pubmed publisher
    ..Although these results are promising, further studies are needed to determine the role of cannabinoid pathways in gut inflammation. ..
  8. Rovedatti L, Di Sabatino A, Knowles C, Sengupta N, Biancheri P, Corazza G, et al. Fibroblast activation protein expression in Crohn's disease strictures. Inflamm Bowel Dis. 2011;17:1251-3 pubmed publisher
  9. Gordon J, Di Sabatino A, MacDonald T. The pathophysiologic rationale for biological therapies in inflammatory bowel disease. Curr Opin Gastroenterol. 2005;21:431-7 pubmed
    ..Novel approaches, such as exploiting the antiinflammatory role of cannabinoid receptors, may also prove productive in the future. ..
  10. Gordon J, Pickard K, Di Sabatino A, Prothero J, Pender S, Goggin P, et al. Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease. Inflamm Bowel Dis. 2008;14:195-203 pubmed
    ..We have demonstrated that IgG PCs from patients with IBD express large amounts of MMP-3 and that they appear to be long-lived. These results identify a new pathway by which IgG PCs may damage the gut. ..
  11. Di Sabatino A, Rosado M, Cazzola P, Biancheri P, Tinozzi F, Laera M, et al. Splenic function and IgM-memory B cells in Crohn's disease patients treated with infliximab. Inflamm Bowel Dis. 2008;14:591-6 pubmed publisher
    ..Restoration of splenic function after infliximab treatment is intriguing and requires further investigation. ..
  12. Di Sabatino A, Pickard K, Rampton D, Kruidenier L, Rovedatti L, Leakey N, et al. Blockade of transforming growth factor beta upregulates T-box transcription factor T-bet, and increases T helper cell type 1 cytokine and matrix metalloproteinase-3 production in the human gut mucosa. Gut. 2008;57:605-12 pubmed publisher
    ..The findings support a crucial role for TGFbeta in dampening T cell-mediated tissue-damaging responses in the human gut. ..
  13. MacDonald T, Di Sabatino A. The exposure of infants to Lactobacillus rhamnosus GG in Finland. J Pediatr Gastroenterol Nutr. 2006;42:476-8 pubmed
  14. Di Sabatino A, Rovedatti L, Vetrano S, Vidali F, Biancheri P, Rescigno M, et al. Involvement of CD40-CD40 ligand in uncomplicated and refractory celiac disease. Am J Gastroenterol. 2011;106:519-27 pubmed publisher
    ..Our results indicate that the CD40-CD40L pathway has a key role in celiac disease. Disruption of CD40-CD40L interaction may offer a therapeutic alternative in refractory celiac disease. ..
  15. Di Sabatino A, Biancheri P, Piconese S, Rosado M, Ardizzone S, Rovedatti L, et al. Peripheral regulatory T cells and serum transforming growth factor-?: relationship with clinical response to infliximab in Crohn's disease. Inflamm Bowel Dis. 2010;16:1891-7 pubmed publisher
    ..This study suggests that there may be a relationship between numbers of Treg in the blood, serum TGF-?1, and response to infliximab; however, further prospective studies are needed. ..
  16. Di Sabatino A, Paccagnini D, Vidali F, Rosu V, Biancheri P, Cossu A, et al. Detection of Mycobacterium avium subsp. paratuberculosis (MAP)-specific IS900 DNA and antibodies against MAP peptides and lysate in the blood of Crohn's disease patients. Inflamm Bowel Dis. 2011;17:1254-5 pubmed publisher
  17. Di Sabatino A, Rovedatti L, Rosado M, Carsetti R, Corazza G, MacDonald T. Increased expression of mucosal addressin cell adhesion molecule 1 in the duodenum of patients with active celiac disease is associated with depletion of integrin alpha4beta7-positive T cells in blood. Hum Pathol. 2009;40:699-704 pubmed publisher
    ..We conclude that mucosal addressin cell adhesion molecule 1 may represent an important determinant for the generation of mucosal damage in celiac disease. ..
  18. Di Sabatino A, Jackson C, Pickard K, Buckley M, Rovedatti L, Leakey N, et al. Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures. Gut. 2009;58:777-89 pubmed publisher
    ..Changes in TGF-beta signalling and MMP production were identified in the mucosa overlying strictures in CD which may give a window into the process of fibrosis. ..
  19. Di Sabatino A, Corazza G. Coeliac disease. Lancet. 2009;373:1480-93 pubmed publisher
    ..In this Seminar we critically reassess the clinical and diagnostic aspects of this disease and new perspectives in its pathogenesis and treatment. ..
  20. De Leo V, Di Sabatino A, Musacchio M, Morgante G, Scolaro V, Cianci A, et al. Effect of oral contraceptives on markers of hyperandrogenism and SHBG in women with polycystic ovary syndrome. Contraception. 2010;82:276-80 pubmed publisher
    ..Clinical studies need to be performed to determine effects of these OCs upon clinical signs of hyperandrogenism. ..
  21. De Leo V, Musacchio M, Palermo V, Di Sabatino A, Morgante G, Petraglia F. Polycystic ovary syndrome and metabolic comorbidities: therapeutic options. Drugs Today (Barc). 2009;45:763-75 pubmed publisher
    ..In this review the metabolic comorbidities of PCOS and their therapeutic options are discussed. ..
  22. Rovedatti L, Kudo T, Biancheri P, Sarra M, Knowles C, Rampton D, et al. Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut. 2009;58:1629-36 pubmed publisher
    ..The abundant IL17 in inflamed IBD mucosa may help explain the relative lack of efficacy of anti-IFNgamma antibodies in clinical trials of Crohn's disease. ..
  23. Di Sabatino A, Ciccocioppo R, Benazzato L, Sturniolo G, Corazza G. Infliximab downregulates basic fibroblast growth factor and vascular endothelial growth factor in Crohn's disease patients. Aliment Pharmacol Ther. 2004;19:1019-24 pubmed
    ..The action of infliximab in reducing serum basic fibroblast growth factor and vascular endothelial growth factor would seem to suggest a role of this agent in down-regulating the process of intestinal fibrogenesis in Crohn's disease. ..
  24. Di Sabatino A, Bertrandi E, Casadei Maldini M, Pennese F, Proietti F, Corazza G. Phenotyping of peripheral blood lymphocytes in adult coeliac disease. Immunology. 1998;95:572-6 pubmed
    ..The decrease of natural killer cells and cytotoxic cells may be in keeping with the increased prevalence of malignancy in this condition. Finally, the phenotypic changes found in untreated coeliacs indicate T-cell activation. ..
  25. Di Sabatino A, Corazza G. Surviving too long in Crohn's disease. Gut. 2001;49:6-8 pubmed
  26. Di Sabatino A, Ciccocioppo R, D Alò S, Parroni R, Millimaggi D, Cifone M, et al. Intraepithelial and lamina propria lymphocytes show distinct patterns of apoptosis whereas both populations are active in Fas based cytotoxicity in coeliac disease. Gut. 2001;49:380-6 pubmed
    ..Increased LPL apoptosis is likely to downregulate mucosal inflammation whereas decreased IEL apoptosis could be responsible for autoimmune and malignant complications of CD. ..
  27. Ciccocioppo R, Di Sabatino A, Luinetti O, Rossi M, Cifone M, Corazza G. Small bowel enterocyte apoptosis and proliferation are increased in the elderly. Gerontology. 2002;48:204-8 pubmed
    ....
  28. Martucci S, Biagi F, Di Sabatino A, Corazza G. Coeliac disease. Dig Liver Dis. 2002;34 Suppl 2:S150-3 pubmed
    ..Extra-intestinal signs, i.e., alopecia, unexplained neurological disorders, cryptic hypertransaminasaemia, increased red cell width, frequently constitute the only clinical manifestation at the diagnosis. ..
  29. Di Sabatino A, Ciccocioppo R, Cinque B, Millimaggi D, Morera R, Ricevuti L, et al. Defective mucosal T cell death is sustainably reverted by infliximab in a caspase dependent pathway in Crohn's disease. Gut. 2004;53:70-7 pubmed
    ..The sustained LPT proapoptotic action of infliximab, which extends far beyond its circulating half life, may be responsible for the sustained remission induced in Crohn's disease patients by infliximab retreatment. ..
  30. Ciccocioppo R, Finamore A, Ara C, Di Sabatino A, Mengheri E, Corazza G. Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac disease. Am J Clin Pathol. 2006;125:502-11 pubmed
    ....
  31. Di Sabatino A, Ciccocioppo R, Armellini E, Morera R, Ricevuti L, Cazzola P, et al. Serum bFGF and VEGF correlate respectively with bowel wall thickness and intramural blood flow in Crohn's disease. Inflamm Bowel Dis. 2004;10:573-7 pubmed
    ..The higher levels of VEGF in those patients with increased intramural blood flow suggests that VEGF may be considered a marker of angiogenesis in this condition. ..
  32. Di Sabatino A, Boggero A, Miccoli F, Cicolani B. Diversity, distribution and ecology of water mites (Acari: Hydrachnidia and Halacaridae) in high Alpine lakes (Central Alps, Italy). Exp Appl Acarol. 2004;34:199-210 pubmed
    ..We conclude with some considerations of the influence of abiotic and biotic factors on the altitudinal and latitudinal distribution pattern of water mites. ..
  33. De Leo V, Musacchio M, Piomboni P, Di Sabatino A, Morgante G. The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications. Eur J Obstet Gynecol Reprod Biol. 2011;157:63-6 pubmed publisher
    ..To prospectively evaluate the safety of metformin administration during pregnancy in a group of PCOS patients by assessing its effect on the prevalence of gestational complications and neonatal outcome...
  34. MacDonald T, Di Sabatino A, DiSabatino A, Gordon J. Immunopathogenesis of Crohn's disease. JPEN J Parenter Enteral Nutr. 2005;29:S118-24; discussion S124-5, S184-8 pubmed
    ....
  35. Di Sabatino A, Calarota S, Vidali F, MacDonald T, Corazza G. Role of IL-15 in immune-mediated and infectious diseases. Cytokine Growth Factor Rev. 2011;22:19-33 pubmed publisher
    ..Here, we discuss the current understanding of IL-15 role in immune-mediated and infectious diseases as well as its therapeutic use. ..
  36. Di Sabatino A, Biancheri P, Rovedatti L, MacDonald T, Corazza G. New pathogenic paradigms in inflammatory bowel disease. Inflamm Bowel Dis. 2012;18:368-71 pubmed publisher
    ..These new paradigms, together with the no longer "static" but "dynamic" vision of intestinal inflammation, highlight new possible therapeutic targets in inflammatory bowel disease. ..
  37. Di Sabatino A, Carsetti R, Corazza G. Post-splenectomy and hyposplenic states. Lancet. 2011;378:86-97 pubmed publisher
    ..In this Review, we critically assess clinical and diagnostic aspects of splenic dysfunction and highlight new perspectives in the prevention of overwhelming post-splenectomy infections. ..
  38. Di Sabatino A, Brunetti L, Biancheri P, Ciccocioppo R, Guerci M, Casella C, et al. Mucosal changes induced by ischemia-reperfusion injury in a jejunal loop transplanted in oropharynx. Intern Emerg Med. 2013;8:317-25 pubmed publisher
    ..We identified alterations in lymphocyte infiltration, mucosal architecture and epithelial cell turnover, which may give a window to mechanisms of small bowel ischemia-reperfusion in humans. ..
  39. Gordon J, Prothero J, Thornton C, Pickard K, Di Sabatino A, Goggin P, et al. CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-? and MMP-3 production in patients with inflammatory bowel disease. J Crohns Colitis. 2009;3:175-82 pubmed publisher
    ....
  40. Corazza G, Zoli G, Di Sabatino A, Ciccocioppo R, Gasbarrini G. A reassessment of splenic hypofunction in celiac disease. Am J Gastroenterol. 1999;94:391-7 pubmed
    ..In celiac disease splenic hypofunction is accompanied by a reduced phagocyte activity linked to the decreased release of tuftsin. ..
  41. Rescigno M, Di Sabatino A. Dendritic cells in intestinal homeostasis and disease. J Clin Invest. 2009;119:2441-50 pubmed publisher
    ....
  42. Ciccocioppo R, D Alò S, Di Sabatino A, Parroni R, Rossi M, Doglioni C, et al. Mechanisms of villous atrophy in autoimmune enteropathy and coeliac disease. Clin Exp Immunol. 2002;128:88-93 pubmed
    ..These results point to enterocyte autoantibody-dependent cellular cytotoxicity as the prevalent mechanism of increased enterocyte apoptosis in autoimmune enteropathy but not in coeliac disease. ..
  43. Di Sabatino A, Carsetti R, Rosado M, Ciccocioppo R, Cazzola P, Morera R, et al. Immunoglobulin M memory B cell decrease in inflammatory bowel disease. Eur Rev Med Pharmacol Sci. 2004;8:199-203 pubmed
    ..Further studies are necessary to answer the question of whether high risk of infection (abscess development) is promoted by the reduction/depletion of IgM memory B-cell pool in inflammatory bowel disease. ..
  44. Di Sabatino A, Rosado M, Ciccocioppo R, Cazzola P, Morera R, Corazza G, et al. Depletion of immunoglobulin M memory B cells is associated with splenic hypofunction in inflammatory bowel disease. Am J Gastroenterol. 2005;100:1788-95 pubmed
    ..Our findings show that peripheral IgM memory B cells are reduced in inflammatory bowel disease patients and this defect seems to be related to the impairment of splenic function. ..
  45. Di Sabatino A, Morera R, Ciccocioppo R, Cazzola P, Gotti S, Tinozzi F, et al. Oral butyrate for mildly to moderately active Crohn's disease. Aliment Pharmacol Ther. 2005;22:789-94 pubmed
    ..These data indicate the need for a large investigation to extend the present findings, and suggest that butyrate may exert its action through downregulation of NF-kappaB and IL-1beta. ..
  46. Maconi G, Di Sabatino A, Ardizzone S, Greco S, Colombo E, Russo A, et al. Prevalence and clinical significance of sonographic detection of enlarged regional lymph nodes in Crohn's disease. Scand J Gastroenterol. 2005;40:1328-33 pubmed
    ....
  47. Di Sabatino A, Rosado M, Cazzola P, Riboni R, Biagi F, Carsetti R, et al. Splenic hypofunction and the spectrum of autoimmune and malignant complications in celiac disease. Clin Gastroenterol Hepatol. 2006;4:179-86 pubmed
    ..IgM memory B cells are reduced in AID-associated and complicated CD. This defect, which is related to the impairment of splenic function, might predispose hyposplenic CD patients to infections by encapsulated bacteria. ..
  48. Colombo P, Benedetti M, Tinozzi F, Ticozzelli E, Maroni N, Di Sabatino A, et al. [Different approaches for medical or surgical management of Crohn's disease: the importance of the classification of Vienna]. Ann Ital Chir. 2006;77:485-96 pubmed
    ..e. fistulas) have a specific indication for immunosuppressive or anti-tumour necrosis factor-alpha therapy. ..
  49. Bergamaschi G, Markopoulos K, Albertini R, Di Sabatino A, Biagi F, Ciccocioppo R, et al. Anemia of chronic disease and defective erythropoietin production in patients with celiac disease. Haematologica. 2008;93:1785-91 pubmed publisher
    ..Suppression of intestinal inflammatory changes as a result of a gluten-free diet improves anemia by correcting iron and vitamin malabsorption as well as mechanisms contributing to anemia of chronic disease. ..
  50. Di Sabatino A, Saarialho Kere U, Buckley M, Gordon J, Biancheri P, Rovedatti L, et al. Stromelysin-1 and macrophage metalloelastase expression in the intestinal mucosa of Crohn's disease patients treated with infliximab. Eur J Gastroenterol Hepatol. 2009;21:1049-55 pubmed publisher
    ..No change in MMP expression was found in nonresponders. The downregulation of tissue degrading MMPs in CD mucosa may explain the wound repair capacity of infliximab in healing fistulas and ulcers. ..
  51. MacDonald T, Vossenkamper A, Voessenkamper A, Di Sabatino A. Antigen presenting cells and T cell interactions in the gastrointestinal tract. Mol Nutr Food Res. 2009;53:947-51 pubmed publisher
    ..We present evidence that type I INF made by plasmacytoid dendritic cells may be important in coeliac disease...
  52. Di Sabatino A, Rovedatti L, Kaur R, Spencer J, Brown J, Morisset V, et al. Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease. J Immunol. 2009;183:3454-62 pubmed publisher
    ....
  53. Bergamaschi G, Di Sabatino A, Albertini R, Ardizzone S, Biancheri P, Bonetti E, et al. Prevalence and pathogenesis of anemia in inflammatory bowel disease. Influence of anti-tumor necrosis factor-alpha treatment. Haematologica. 2010;95:199-205 pubmed publisher
    ..In patients requiring anti-tumor necrosis factor-alpha treatment, response to therapy improves erythropoiesis. ..
  54. Di Sabatino A, Pender S, Jackson C, Prothero J, Gordon J, Picariello L, et al. Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies. Gastroenterology. 2007;133:137-49 pubmed
    ..Our findings show a novel therapeutic pathway for anti-TNF therapies in enhancing TIMP-1 production and myofibroblast migration, which may reduce MMP activity and facilitate the wound healing. ..
  55. Morgante G, Scolaro V, Tosti C, Di Sabatino A, Piomboni P, De Leo V. [Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia]. Minerva Urol Nefrol. 2010;62:213-8 pubmed
    ..Sexual satisfaction was measured using the sexual satisfaction index (SSI). At the end of therapy, a significant improvement was observed in progressive sperm motility on spermiogram evaluation and in SSI scores in the treatment group. ..
  56. Morgante G, Orvieto R, Di Sabatino A, Musacchio M, De Leo V. The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen. Fertil Steril. 2011;95:2642-4 pubmed publisher
    ..Inositol nutritional supplementation produced very good clinical results with a significant reduction in cancellation rate (0 vs. 40%) and the consequent improvement in clinical pregnancy rate (PR) (33.3% vs. 13.3%). ..
  57. Papadia C, Kelly P, Caini S, Corazza G, Shawa T, Franze A, et al. Plasma citrulline as a quantitative biomarker of HIV-associated villous atrophy in a tropical enteropathy population. Clin Nutr. 2010;29:795-800 pubmed publisher
    ..Serum citrulline concentration appears to be a quantitative biomarker of small bowel mass integrity in HIV positive enteropathy and deserves assessment as a surrogate for monitoring anti-retroviral therapy. ..
  58. Vidali F, Di Sabatino A, Broglia F, Cazzola P, Biancheri P, Viera F, et al. Increased CD8+ intraepithelial lymphocyte infiltration and reduced surface area to volume ratio in the duodenum of patients with ulcerative colitis. Scand J Gastroenterol. 2010;45:684-9 pubmed publisher
    ..Further studies are needed to clarify whether the duodenum is a target organ in UC. ..
  59. Ciccocioppo R, Di Sabatino A, Bauer M, Della Riccia D, Bizzini F, Biagi F, et al. Matrix metalloproteinase pattern in celiac duodenal mucosa. Lab Invest. 2005;85:397-407 pubmed
    ..In conclusion, our results show the presence of a peculiar MMP pattern in active CD strongly dominated by MMP-12, correlating either with IFN-gamma or the degree of mucosal damage. ..
  60. Di Sabatino A, Ciccocioppo R, Luinetti O, Ricevuti L, Morera R, Cifone M, et al. Increased enterocyte apoptosis in inflamed areas of Crohn's disease. Dis Colon Rectum. 2003;46:1498-507 pubmed
    ..Increased matrix metalloproteinase-1 release from lamina propria mononuclear cells might be one of the possible mechanisms responsible for the increased enterocyte apoptosis in Crohn's disease. ..
  61. Di Sabatino A, Rovedatti L, Vidali F, Macdonald T, Corazza G. Recent advances in understanding Crohn's disease. Intern Emerg Med. 2013;8:101-13 pubmed publisher
    ..This review is focused on novel advances in basic and clinical aspects of Crohn's disease, although it also deals with new trends in diagnosis and treatment. ..
  62. Bergamaschi G, Di Sabatino A, Pasini A, Ubezio C, Costanzo F, Grataroli D, et al. Intestinal expression of genes implicated in iron absorption and their regulation by hepcidin. Clin Nutr. 2017;36:1427-1433 pubmed publisher
    ....
  63. Di Sabatino A, Lenti M, Tinozzi F, Lanave M, Aquino I, Klersy C, et al. Vaccination coverage and mortality after splenectomy: results from an Italian single-centre study. Intern Emerg Med. 2017;12:1139-1147 pubmed publisher
    ..Our results show that two-thirds of splenectomised patients comply with vaccine prophylaxis. Future interventional studies or ad hoc registries might overcome barriers to vaccination or intentional non-compliance. ..