Giovanni Destro Bisol

Summary

Affiliation: University La Sapienza
Location: Roma, Italy
Summary:
CURRENT RESEARCH PROJECTS

Genetic history of the population of sub-Saharan Africa.
The project aims to reconstruct the processes that have affected the Nigero-Cameroon population plateau integrating biological information with cultural aspects.

Genetic adaptations in human populations.
I tested the hypothesis that the interaction between derivatives of oxidation of hemoglobin and red cell membrane proteins is a mechanism which is at work in different genetic adaptations to malaria. More recently, I worked on lactase persistence in European and African populations in order to detect signatures of selection.

Interdisciplinary study of Italian language minorities.
The research focused on the German-speaking community of Veneto (Sappada) and Friuli (Sauris, Timau) and Trentino (Cimbri, Ladin and neighboring groups), in order to determine the relationships between cultural, demographic and genetic factors.

Data-sharing in human population genetic studies.
I am currently investigating the mode and extent of research data sharing in evolutionary, forensic and medical genetics, focusing on polymorphisms of mitochondrial DNA and Y chromosome.

Publications

  1. ncbi request reprint Brief communication: mtDNA variation in North Cameroon: lack of Asian lineages and implications for back migration from Asia to sub-Saharan Africa
    Valentina Coia
    Department of Animal and Human Biology, University La Sapienza, 00185 Rome, Italy
    Am J Phys Anthropol 128:678-81. 2005
  2. ncbi request reprint HLA class I variation in the West African Pygmies and their genetic relationship with other African populations
    J Bruges Armas
    Immunogenetic Service, Hospital Santo Espirito de Angra do Heroismo, Azores, Portugal
    Tissue Antigens 62:233-42. 2003
  3. doi request reprint Using forensic microsatellites to decipher the genetic structure of linguistic and geographic isolates: A survey in the eastern Italian Alps
    Francesco Montinaro
    Universita di Roma La Sapienza, Dipartimento di Biologia Ambientale, Roma, Italy
    Forensic Sci Int Genet 6:827-33. 2012
  4. ncbi request reprint Phylogeography of the human mitochondrial L1c haplogroup: genetic signatures of the prehistory of Central Africa
    Chiara Batini
    Dipartimento di Biologia Animale e dell Uomo, Universita La Sapienza, Roma, Italy
    Mol Phylogenet Evol 43:635-44. 2007
  5. pmc A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis
    Heiko Witt
    Department of Hepatology and Gastroenterology, Charite University Hospital, Augustenburger Platz 1, 13353 Berlin, Germany
    Nat Genet 38:668-73. 2006
  6. ncbi request reprint Variation of the insulin receptor substrate gene (IRS-1) in African Pygmies and Bantus
    C Battaggia
    Diabetes Res Clin Pract 72:108-9. 2006
  7. ncbi request reprint Microsatellite variation and evolution of human lactase persistence
    Margarida Coelho
    Instituto de Patologia e Imunologia Molecular, Universidade do Porto IPATIMUP, R Dr Roberto Frias s n, 4200 465 Porto, Portugal
    Hum Genet 117:329-39. 2005
  8. pmc The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time
    Lev A Zhivotovsky
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
    Am J Hum Genet 74:50-61. 2004
  9. ncbi request reprint Binary and microsatellite polymorphisms of the Y-chromosome in the Mbenzele pygmies from the Central African Republic
    Valentina Coia
    Department of Animal and Human Biology, University La Sapienza, Rome, Italy
    Am J Hum Biol 16:57-67. 2004
  10. ncbi request reprint A study of Y-chromosome microsatellite variation in sub-Saharan Africa: a comparison between F(ST) and R(ST) genetic distances
    Alessandra Caglià
    Dipartimento di Biologia Animale e dell Uomo, Universita La Sapienza, Rome, Italy
    Hum Biol 75:313-30. 2003

Detail Information

Publications70

  1. ncbi request reprint Brief communication: mtDNA variation in North Cameroon: lack of Asian lineages and implications for back migration from Asia to sub-Saharan Africa
    Valentina Coia
    Department of Animal and Human Biology, University La Sapienza, 00185 Rome, Italy
    Am J Phys Anthropol 128:678-81. 2005
    ....
  2. ncbi request reprint HLA class I variation in the West African Pygmies and their genetic relationship with other African populations
    J Bruges Armas
    Immunogenetic Service, Hospital Santo Espirito de Angra do Heroismo, Azores, Portugal
    Tissue Antigens 62:233-42. 2003
    ..However, both the genetic distances and the within-group variation suggests that the Bakola are more admixed with Bantu farmers than Mbenzele...
  3. doi request reprint Using forensic microsatellites to decipher the genetic structure of linguistic and geographic isolates: A survey in the eastern Italian Alps
    Francesco Montinaro
    Universita di Roma La Sapienza, Dipartimento di Biologia Ambientale, Roma, Italy
    Forensic Sci Int Genet 6:827-33. 2012
    ..These findings point to the importance of considering the demographic and cultural profile of populations in forensic applications, even in a context of substantial genetic homogeneity such as that of European populations...
  4. ncbi request reprint Phylogeography of the human mitochondrial L1c haplogroup: genetic signatures of the prehistory of Central Africa
    Chiara Batini
    Dipartimento di Biologia Animale e dell Uomo, Universita La Sapienza, Roma, Italy
    Mol Phylogenet Evol 43:635-44. 2007
    ....
  5. pmc A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis
    Heiko Witt
    Department of Hepatology and Gastroenterology, Charite University Hospital, Augustenburger Platz 1, 13353 Berlin, Germany
    Nat Genet 38:668-73. 2006
    ..In conclusion, the G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis...
  6. ncbi request reprint Variation of the insulin receptor substrate gene (IRS-1) in African Pygmies and Bantus
    C Battaggia
    Diabetes Res Clin Pract 72:108-9. 2006
  7. ncbi request reprint Microsatellite variation and evolution of human lactase persistence
    Margarida Coelho
    Instituto de Patologia e Imunologia Molecular, Universidade do Porto IPATIMUP, R Dr Roberto Frias s n, 4200 465 Porto, Portugal
    Hum Genet 117:329-39. 2005
    ....
  8. pmc The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time
    Lev A Zhivotovsky
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
    Am J Hum Genet 74:50-61. 2004
    ..This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria...
  9. ncbi request reprint Binary and microsatellite polymorphisms of the Y-chromosome in the Mbenzele pygmies from the Central African Republic
    Valentina Coia
    Department of Animal and Human Biology, University La Sapienza, Rome, Italy
    Am J Hum Biol 16:57-67. 2004
    ..We suggest that this could be due to the higher phylogenetic stability of Y-chromosome and to the effect of the male-biased gene flow during the Bantu expansion...
  10. ncbi request reprint A study of Y-chromosome microsatellite variation in sub-Saharan Africa: a comparison between F(ST) and R(ST) genetic distances
    Alessandra Caglià
    Dipartimento di Biologia Animale e dell Uomo, Universita La Sapienza, Rome, Italy
    Hum Biol 75:313-30. 2003
    ..On a theoretical ground, we propose that the lesser performance of R(ST) compared to F(ST) could be explained by the important role played by genetic drift in shaping the relationships among examined populations...
  11. ncbi request reprint Variation at 16 STR loci in Rwandans (Hutu) and implications on profile frequency estimation in Bantu-speakers
    Sergio Tofanelli
    Department of Ethology, Ecology and Evolution, Anthropology Unit, University of Pisa, Via S Maria 55, 56126, Pisa, Italy
    Int J Legal Med 117:121-6. 2003
    ..The introduction of a non-negligible bias was confirmed by calculating the differences between multiple-locus profile frequencies of western and eastern Bantoids using local and non-local reference databases...
  12. ncbi request reprint Variation of the hypervariable region-1 of mitochondrial DNA in central-eastern Italy
    F Verginelli
    Department of Human and Animal Biology, University of Rome La Sapienza, Italy
    J Forensic Sci 48:443-4. 2003
  13. ncbi request reprint Frequencies at CD4, FES, and F13A1 microsatellite loci in central-southern Sardinia (Italy)
    C Battaggia
    Department of Animal and Human Biology, University La Sapienza, Rome, Italy
    J Forensic Sci 48:442. 2003
  14. pmc Evidence for balancing selection from nucleotide sequence analyses of human G6PD
    Brian C Verrelli
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Am J Hum Genet 71:1112-28. 2002
    ..The present study demonstrates that nucleotide sequence analyses can reveal signatures of both historical and recent selection in the genome and may elucidate the impact that infectious disease has had during human evolution...
  15. pmc Inferring human population sizes, divergence times and rates of gene flow from mitochondrial, X and Y chromosome resequencing data
    Daniel Garrigan
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genetics 177:2195-207. 2007
    ..e., from the Bantu-speaking population into other African populations. Conversely, mitochondrial gene flow is more extensive between non-African populations, but appears to be absent between European and Asian populations...
  16. ncbi request reprint Contrasting signatures of population growth for mitochondrial DNA and Y chromosomes among human populations in Africa
    Maya Metni Pilkington
    Department of Anthropology, University of Arizona, USA
    Mol Biol Evol 25:517-25. 2008
    ..We hypothesize that males experienced smaller effective population sizes and/or lower rates of migration during the Bantu expansion, which occurred over the last 5,000 years...
  17. doi request reprint Tracing the distribution and evolution of lactase persistence in Southern Europe through the study of the T(-13910) variant
    Paolo Anagnostou
    Dipartimento di Biologia Animale e dell Uomo, Universita La Sapienza, Roma, Italy
    Am J Hum Biol 21:217-9. 2009
    ..Robust signals of selection can be observed in North-East Italy only. We discuss the possible role of cultural traits and genetic history in determining these observed micro-evolutionary patterns...
  18. doi request reprint Evidence of high genetic variation among linguistically diverse populations on a micro-geographic scale: a case study of the Italian Alps
    Valentina Coia
    Department of Philosophy, History and Cultural Heritage, University of Trento, Trento, Italy
    J Hum Genet 57:254-60. 2012
    ....
  19. doi request reprint HLA class-I diversity in Cameroon: evidence for a north-south structure of genetic variation and relationships with African populations
    Hélder Spínola
    University of Madeira, Human Genetics Laboratory, Funchal, Portugal
    Ann Hum Genet 75:665-77. 2011
    ..On the other hand, signals of shared ancestry between the Bamileke and Ewondo and the Bantu speakers from central and southern Africa were detected...
  20. pmc A revised root for the human Y chromosomal phylogenetic tree: the origin of patrilineal diversity in Africa
    Fulvio Cruciani
    Dipartimento di Biologia e Biotecnologie C Darwin, Sapienza Universita di Roma, Rome 00185, Italy
    Am J Hum Genet 88:814-8. 2011
    ..An analysis of 2204 African DNA samples showed that the deepest clades of the revised MSY phylogeny are currently found in central and northwest Africa, opening new perspectives on early human presence in the continent...
  21. doi request reprint Signatures of the preagricultural peopling processes in sub-Saharan Africa as revealed by the phylogeography of early Y chromosome lineages
    Chiara Batini
    Institute of Evolutionary Biology, Universitat Pompeu Fabra Institut de Biologia Evolutiva, Consejo Superior de Investigationes Científicas, Barcelona, Spain
    Mol Biol Evol 28:2603-13. 2011
    ..These results open new perspectives on the early history of Homo sapiens in Africa, with particular attention to areas of the continent where human fossil remains and archaeological data are scant...
  22. doi request reprint Insights into the demographic history of African Pygmies from complete mitochondrial genomes
    Chiara Batini
    Institut de Biologia Evolutiva CSIC UPF, Department de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Mol Biol Evol 28:1099-110. 2011
    ....
  23. ncbi request reprint Molecular anthropology in the genomic era
    Giovanni Destro-Bisol
    Istituto Italiano di Antropologia, Rome, Italy
    J Anthropol Sci 88:93-112. 2010
    ..Here we present an overview of the meeting and discuss perspectives and prospects of Molecular Anthropology in the genomic era...
  24. ncbi request reprint Mitochondrial, Y-chromosomal and autosomal variation in Mbenzele Pygmies from the Central African Republic
    Paolo Anagnostou
    Department of Animal and Human Biology, University La Sapienza, Rome, Italy
    Coll Antropol 34:535-43. 2010
    ....
  25. doi request reprint Evolution of detoxifying systems: the role of environment and population history in shaping genetic diversity at human CYP2D6 locus
    Silvia Fuselli
    Department of Biology and Evolution, University of Ferrara, Ferrara, Italy
    Pharmacogenet Genomics 20:485-99. 2010
    ..Here we test the hypothesis that high levels of genetic variation at CYP2D6, a locus coding for a detoxifying enzyme of the cytochrome P450 complex, reflect this change...
  26. ncbi request reprint Clinal variation in the nuclear DNA of Europeans. 1998
    Lounes Chikhi
    Hum Biol 81:625-38. 2009
  27. pmc Human Y chromosome haplogroup R-V88: a paternal genetic record of early mid Holocene trans-Saharan connections and the spread of Chadic languages
    Fulvio Cruciani
    Dipartimento di Genetica e Biologia Molecolare, Sapienza Universita di Roma, Rome, Italy
    Eur J Hum Genet 18:800-7. 2010
    ....
  28. doi request reprint A multi-perspective view of genetic variation in Cameroon
    V Coia
    Dipartimento di Biologia Animale e dell Uomo, Sapienza Universita di Roma, Roma 00185, Italia
    Am J Phys Anthropol 140:454-64. 2009
    ....
  29. ncbi request reprint Variation at 10 protein coding loci in the Mbenzele Pygmies from the Central African Republic and a comparison with microsatellite data
    Valentina Coia
    Department of Animal and Human Biology, University La Sapienza, Rome, Italy
    Am J Hum Biol 14:9-14. 2002
    ....
  30. pmc A back migration from Asia to sub-Saharan Africa is supported by high-resolution analysis of human Y-chromosome haplotypes
    Fulvio Cruciani
    Dipartimenti di Genetica e Biologia Molecolare, Universita La Sapienza, Rome, Italy
    Am J Hum Genet 70:1197-214. 2002
    ..Haplogroup IX Y chromosomes appear to have been involved in such a migration, the traces of which can now be observed mostly in northern Cameroon...
  31. ncbi request reprint Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance
    S A Tishkoff
    Department of Biology, Biology Psychology Building, University of Maryland, College Park, MD 20742, USA
    Science 293:455-62. 2001
    ..These results support the hypothesis that malaria has had a major impact on humans only since the introduction of agriculture within the past 10,000 years and provide a striking example of the signature of selection on the human genome...
  32. pmc Short tandem-repeat polymorphism/alu haplotype variation at the PLAT locus: implications for modern human origins
    S A Tishkoff
    University of Maryland, Department of Biology, University of Maryland, College Park, MD 20742, USA
    Am J Hum Genet 67:901-25. 2000
    ....
  33. ncbi request reprint Microsatellite variation in Central Africa: an analysis of intrapopulational and interpopulational genetic diversity
    G Destro-Bisol
    Department of Animal and Human Biology, University La Sapienza, Rome, Italy
    Am J Phys Anthropol 112:319-37. 2000
    ..This is probably due to the differentiating effect of genetic drift, which is enhanced by the small effective size of Pygmy populations...
  34. ncbi request reprint Genetic resistance to malaria, oxidative stress and hemoglobin oxidation
    G Destro Bisol
    Department of Animal and Human Biology, University of Rome La Sapienza, Italy
    Parassitologia 41:203-4. 1999
    ....
  35. ncbi request reprint Variability at the uridine diphosphate glucuronosyltransferase 1A1 promoter in human populations and primates
    D Hall
    Department of Human Genetics, University of Chicago, Illinois 60637, USA
    Pharmacogenetics 9:591-9. 1999
    ..Our findings are consistent with the proposal that the TA repeat variation is a balanced polymorphism...
  36. ncbi request reprint The peopling of sub-Saharan Africa: the case study of Cameroon
    G Spedini
    Department of Animal and Human Biology, University La Sapienza, Rome, Italy
    Am J Phys Anthropol 110:143-62. 1999
    ..Finally, the Fulbe are genetically distinct from all the populations that belong to their same linguistic phylum (NK), and closer to the neighboring Fali and Tupuri, eastern Adamawa speaking groups of north Cameroon...
  37. ncbi request reprint Estimating European admixture in African Americans by using microsatellites and a microsatellite haplotype (CD4/Alu)
    G Destro-Bisol
    Department of Animal and Human Biology, University La Sapienza, Roma, Italia
    Hum Genet 104:149-57. 1999
    ..26+/-0.02. The narrow confidence interval indicates that allele frequency data from multiple microsatellite loci, whether analyzed independently or as haplotypes, are particularly useful for estimating genetic admixture...
  38. ncbi request reprint Brief communication: Resistance to Falciparum malaria in alpha-thalassemia, oxidative stress, and hemoglobin oxidation
    G Destro-Bisol
    Department of Animal and Human Biology, University of Rome La Sapienza, Italy
    Am J Phys Anthropol 109:269-73. 1999
    ....
  39. doi request reprint Online databases for mtDNA and Y chromosome polymorphisms in human populations
    Alessandra Congiu
    Universita di Roma La Sapienza, Dipartimento di Biologia Ambientale, Roma, Italy
    J Anthropol Sci 90:201-15. 2012
    ....
  40. ncbi request reprint The analysis of variation of mtDNA hypervariable region 1 suggests that Eastern and Western Pygmies diverged before the Bantu expansion
    Giovanni Destro-Bisol
    Dipartimento di Biologia Animale e dell Uomo, Universita La Sapienza, P le A Moro 5, 00185 Roma, Italy
    Am Nat 163:212-26. 2004
    ....
  41. ncbi request reprint Variation of female and male lineages in sub-Saharan populations: the importance of sociocultural factors
    Giovanni Destro-Bisol
    Department of Animal and Human Biology, University La Sapienza, Rome, Italy
    Mol Biol Evol 21:1673-82. 2004
    ....
  42. pmc Mine, yours, ours? Sharing data on human genetic variation
    Nicola Milia
    Dipartimento di Biologia Ambientale, Universita di Roma La Sapienza, Roma Italy
    PLoS ONE 7:e37552. 2012
    ..By making the scientific community and the public aware of this important aspect, we may help popularize a more effective culture of data sharing...
  43. ncbi request reprint Contrasting patterns of Y chromosome and mtDNA variation in Africa: evidence for sex-biased demographic processes
    Elizabeth T Wood
    Division of Biotechnology, University of Arizona, Tucson, AZ 85721, USA
    Eur J Hum Genet 13:867-76. 2005
    ....
  44. pmc Testing for archaic hominin admixture on the X chromosome: model likelihoods for the modern human RRM2P4 region from summaries of genealogical topology under the structured coalescent
    Murray P Cox
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721, USA
    Genetics 178:427-37. 2008
    ..The pmc summary statistic, which has improved power with larger samples of chromosomes, yields values that are significantly unlikely under the RAR model and fit expectations better under a range of archaic admixture scenarios...
  45. ncbi request reprint Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene
    Valentina Coia
    Institute for Tropical Medicine, Department of Parasitology, University of Tubingen, Wilhelmstr 27, 72074 Tubingen, Germany
    Biochem Biophys Res Commun 335:1123-31. 2005
    ..Three point mutations were identified in this region. In vitro studies with promoter constructs showed an altered expression of the marker gene depending on the promoter variant used...