Massimo Derenzini

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. pmc Nucleolus, ribosomes, and cancer
    Lorenzo Montanaro
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Am J Pathol 173:301-10. 2008
  2. pmc Nucleolar function and size in cancer cells
    M Derenzini
    Department of Experimental Pathology, S Orsola Hospital, University of Bologna, Italy
    Am J Pathol 152:1291-7. 1998
  3. ncbi The AgNORs
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita degli Studi di Bologna, Italy
    Micron 31:117-20. 2000
  4. pmc Thymidylate synthase protein expression and activity are related to the cell proliferation rate in human cancer cell lines
    M Derenzini
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126, Bologna, Italy
    Mol Pathol 55:310-4. 2002
  5. ncbi Evaluation of thymidylate synthase protein expression by Western blotting and immunohistochemistry on human colon carcinoma xenografts in nude mice
    Massimo Derenzini
    Department of Experimental Pathology, University of Bologna, Italy
    J Histochem Cytochem 50:1633-40. 2002
  6. ncbi The p53-mediated sensitivity of cancer cells to chemotherapeutic agents is conditioned by the status of the retinoblastoma protein
    Massimo Derenzini
    Clinical Department of Radiological and Histopathological Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    J Pathol 219:373-82. 2009
  7. doi Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure
    Massimo Derenzini
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    Clin Cancer Res 14:2199-209. 2008
  8. ncbi Novel dyskerin-mediated mechanism of p53 inactivation through defective mRNA translation
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Cancer Res 70:4767-77. 2010
  9. doi Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation
    Giulio Donati
    Dipartimento di Patologia Sperimentale, Universita di Bologna, 40126 Bologna, Italy
    J Cell Sci 124:3017-28. 2011
  10. ncbi Relationship between dyskerin expression and telomerase activity in human breast cancer
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italy
    Cell Oncol 30:483-90. 2008

Detail Information

Publications24

  1. pmc Nucleolus, ribosomes, and cancer
    Lorenzo Montanaro
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Am J Pathol 173:301-10. 2008
    ....
  2. pmc Nucleolar function and size in cancer cells
    M Derenzini
    Department of Experimental Pathology, S Orsola Hospital, University of Bologna, Italy
    Am J Pathol 152:1291-7. 1998
    ..Quantitative distribution of nucleolar structures within the cell represents a cytohistological parameter of the rapidity of cell proliferation...
  3. ncbi The AgNORs
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita degli Studi di Bologna, Italy
    Micron 31:117-20. 2000
    ..The "AgNOR" parameter has been proved to represent a reliable tool for defining the clinical outcome of cancer disease, being an independent prognostic factor in many types of tumors...
  4. pmc Thymidylate synthase protein expression and activity are related to the cell proliferation rate in human cancer cell lines
    M Derenzini
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126, Bologna, Italy
    Mol Pathol 55:310-4. 2002
    ..To ascertain whether the expression and enzyme activity of thymidylate synthase (TS) are related to the rapidity of cell proliferation in human cancer cell lines...
  5. ncbi Evaluation of thymidylate synthase protein expression by Western blotting and immunohistochemistry on human colon carcinoma xenografts in nude mice
    Massimo Derenzini
    Department of Experimental Pathology, University of Bologna, Italy
    J Histochem Cytochem 50:1633-40. 2002
    ....
  6. ncbi The p53-mediated sensitivity of cancer cells to chemotherapeutic agents is conditioned by the status of the retinoblastoma protein
    Massimo Derenzini
    Clinical Department of Radiological and Histopathological Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    J Pathol 219:373-82. 2009
    ....
  7. doi Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure
    Massimo Derenzini
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    Clin Cancer Res 14:2199-209. 2008
    ....
  8. ncbi Novel dyskerin-mediated mechanism of p53 inactivation through defective mRNA translation
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Cancer Res 70:4767-77. 2010
    ..Our findings suggest that a dyskerin-mediated mechanism of p53 inactivation may occur in a subset of human tumors...
  9. doi Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation
    Giulio Donati
    Dipartimento di Patologia Sperimentale, Universita di Bologna, 40126 Bologna, Italy
    J Cell Sci 124:3017-28. 2011
    ....
  10. ncbi Relationship between dyskerin expression and telomerase activity in human breast cancer
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italy
    Cell Oncol 30:483-90. 2008
    ..This should be taken into consideration when utilizing TERT expression as a surrogate indicator of telomerase activity in tumour pathology...
  11. ncbi Key role of the achievement of an appropriate ribosomal RNA complement for G1-S phase transition in H4-II-E-C3 rat hepatoma cells
    Massimo Derenzini
    Dipartimento di Patologia Sperimentale, Sezione di Patologia Clinica, Universita di Bologna, Bologna, Italia
    J Cell Physiol 202:483-91. 2005
    ..Our results indicated that the achievement of an appropriate amount of rRNA allows G1/S phase transition, probably by modulating the expression of cyclin E mRNA...
  12. pmc Cell proliferation of esophageal squamous epithelium in erosive and non-erosive reflux disease
    Carlo Calabrese
    Department of Clinical Medicine, University of Bologna, 40138 Bologna, Italy
    World J Gastroenterol 17:4496-502. 2011
    ..To elucidate cell proliferation in erosive reflux disease (ERD) and non-erosive reflux disease (NERD), we evaluated markers in squamous epithelial cells...
  13. ncbi Location of rRNA transcription to the nucleolar components: disappearance of the fibrillar centers in nucleoli of regenerating rat hepatocytes
    Lorenzo Montanaro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Cell Struct Funct 36:49-56. 2011
    ....
  14. ncbi Cell proliferation in breast cancer is a major determinant of clinical outcome in node-positive but not in node-negative patients
    Davide Trere
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Italy
    Appl Immunohistochem Mol Morphol 14:314-23. 2006
    ..Within this subgroup, the rapidity of cell proliferation as assessed by AgNOR analysis also served as a sensitive predictor of the response to adjuvant treatments...
  15. ncbi Nucleolar size and activity are related to pRb and p53 status in human breast cancer
    Davide Trere
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    J Histochem Cytochem 52:1601-7. 2004
    ....
  16. doi Ribosome biogenesis and control of cell proliferation: p53 is not alone
    Giulio Donati
    Department of Experimental Pathology, Alma Mater Studiorum, Universita di Bologna, Bologna, Italy
    Cancer Res 72:1602-7. 2012
    ....
  17. doi What the nucleolus says to a tumour pathologist
    Massimo Derenzini
    Dipartimento di Scienze Cliniche Radiologiche e Istocitopatologiche, Universita di Bologna, Bologna, Italy
    Histopathology 54:753-62. 2009
    ..Indeed, a series of studies carried out on numerous human tumours has shown that nucleolar hypertrophy (prominent nucleolus) was an independent predictive and prognostic parameter of a fatal clinical outcome...
  18. ncbi Structural and functional organization of ribosomal genes within the mammalian cell nucleolus
    Massimo Derenzini
    Dipartimento di Patologia Sperimentale, Via S Giacomo 14, 40126 Bologna, Italy
    J Histochem Cytochem 54:131-45. 2006
    ..The presence of rDNA in mammalian cells always structurally ready for transcription might facilitate a more rapid adjustment of the ribosome production in response to the metabolic needs of the cell...
  19. ncbi Interferon plus ribavirin and interferon alone in preventing hepatocellular carcinoma: a prospective study on patients with HCV related cirrhosis
    Francesco Azzaroli
    Department of Internal Medicine, University of Bologna, Via Massarenti 9, 40138 Bologna
    World J Gastroenterol 10:3099-102. 2004
    ..Data on the preventive effect of IFN plus ribavirin treatment are lacking...
  20. pmc Esophageal cell proliferation in gastroesophageal reflux disease: clinical-morphological data before and after pantoprazole
    Carlo Calabrese
    Department of Clinical Medicine, University of Bologna, Bologna, Italy
    World J Gastroenterol 15:936-41. 2009
    ....
  21. ncbi Increased mortality rate and not impaired ribosomal biogenesis is responsible for proliferative defect in dyskeratosis congenita cell lines
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita degli Studi di Bologna, Bologna, Italy
    J Invest Dermatol 118:193-8. 2002
    ....
  22. ncbi Nucleolar hypertrophy correlates with hepatocellular carcinoma development in cirrhosis due to HBV infection
    Davide Trere
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Italy
    Hepatology 37:72-8. 2003
    ....
  23. ncbi Genetic pathways in the evolution of breast ductal carcinoma in situ
    Fulvia Farabegoli
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    J Pathol 196:280-6. 2002
    ..The evolution from DCIS to IDC may follow multiple pathways and not a linear model...
  24. ncbi Liver-targeted doxorubicin: effects on rat regenerating hepatocytes
    Giuseppina Di Stefano
    Department of Experimental Pathology, University of Bologna, Via San Giacomo, Bologna, Italy
    Liver Int 24:246-52. 2004
    ....