Massimo Derenzini

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. doi request reprint What the nucleolus says to a tumour pathologist
    Massimo Derenzini
    Dipartimento di Scienze Cliniche Radiologiche e Istocitopatologiche, Universita di Bologna, Bologna, Italy
    Histopathology 54:753-62. 2009
  2. ncbi request reprint Chromatin structure in situ: the contribution of DNA ultrastructural cytochemistry
    M Derenzini
    University of Bologna
    Eur J Histochem 58:2307. 2014
  3. ncbi request reprint Structural and functional organization of ribosomal genes within the mammalian cell nucleolus
    Massimo Derenzini
    Dipartimento di Patologia Sperimentale, Via S Giacomo 14, 40126 Bologna, Italy
    J Histochem Cytochem 54:131-45. 2006
  4. doi request reprint Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure
    Massimo Derenzini
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    Clin Cancer Res 14:2199-209. 2008
  5. ncbi request reprint Relationship between the RB1 mRNA level and the expression of phosphorylated RB protein in human breast cancers: their relevance in cell proliferation activity and patient clinical outcome
    M Derenzini
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    Histol Histopathol 22:505-13. 2007
  6. ncbi request reprint Key role of the achievement of an appropriate ribosomal RNA complement for G1-S phase transition in H4-II-E-C3 rat hepatoma cells
    Massimo Derenzini
    Dipartimento di Patologia Sperimentale, Sezione di Patologia Clinica, Universita di Bologna, Bologna, Italia
    J Cell Physiol 202:483-91. 2005
  7. ncbi request reprint The p53-mediated sensitivity of cancer cells to chemotherapeutic agents is conditioned by the status of the retinoblastoma protein
    Massimo Derenzini
    Clinical Department of Radiological and Histopathological Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    J Pathol 219:373-82. 2009
  8. ncbi request reprint Novel dyskerin-mediated mechanism of p53 inactivation through defective mRNA translation
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Cancer Res 70:4767-77. 2010
  9. doi request reprint Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation
    Giulio Donati
    Dipartimento di Patologia Sperimentale, Universita di Bologna, 40126 Bologna, Italy
    J Cell Sci 124:3017-28. 2011
  10. ncbi request reprint Relationship between dyskerin expression and telomerase activity in human breast cancer
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italy
    Cell Oncol 30:483-90. 2008

Detail Information

Publications47

  1. doi request reprint What the nucleolus says to a tumour pathologist
    Massimo Derenzini
    Dipartimento di Scienze Cliniche Radiologiche e Istocitopatologiche, Universita di Bologna, Bologna, Italy
    Histopathology 54:753-62. 2009
    ..Indeed, a series of studies carried out on numerous human tumours has shown that nucleolar hypertrophy (prominent nucleolus) was an independent predictive and prognostic parameter of a fatal clinical outcome...
  2. ncbi request reprint Chromatin structure in situ: the contribution of DNA ultrastructural cytochemistry
    M Derenzini
    University of Bologna
    Eur J Histochem 58:2307. 2014
    ....
  3. ncbi request reprint Structural and functional organization of ribosomal genes within the mammalian cell nucleolus
    Massimo Derenzini
    Dipartimento di Patologia Sperimentale, Via S Giacomo 14, 40126 Bologna, Italy
    J Histochem Cytochem 54:131-45. 2006
    ..The presence of rDNA in mammalian cells always structurally ready for transcription might facilitate a more rapid adjustment of the ribosome production in response to the metabolic needs of the cell...
  4. doi request reprint Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure
    Massimo Derenzini
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    Clin Cancer Res 14:2199-209. 2008
    ....
  5. ncbi request reprint Relationship between the RB1 mRNA level and the expression of phosphorylated RB protein in human breast cancers: their relevance in cell proliferation activity and patient clinical outcome
    M Derenzini
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    Histol Histopathol 22:505-13. 2007
    ....
  6. ncbi request reprint Key role of the achievement of an appropriate ribosomal RNA complement for G1-S phase transition in H4-II-E-C3 rat hepatoma cells
    Massimo Derenzini
    Dipartimento di Patologia Sperimentale, Sezione di Patologia Clinica, Universita di Bologna, Bologna, Italia
    J Cell Physiol 202:483-91. 2005
    ..Our results indicated that the achievement of an appropriate amount of rRNA allows G1/S phase transition, probably by modulating the expression of cyclin E mRNA...
  7. ncbi request reprint The p53-mediated sensitivity of cancer cells to chemotherapeutic agents is conditioned by the status of the retinoblastoma protein
    Massimo Derenzini
    Clinical Department of Radiological and Histopathological Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    J Pathol 219:373-82. 2009
    ....
  8. ncbi request reprint Novel dyskerin-mediated mechanism of p53 inactivation through defective mRNA translation
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Cancer Res 70:4767-77. 2010
    ..Our findings suggest that a dyskerin-mediated mechanism of p53 inactivation may occur in a subset of human tumors...
  9. doi request reprint Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation
    Giulio Donati
    Dipartimento di Patologia Sperimentale, Universita di Bologna, 40126 Bologna, Italy
    J Cell Sci 124:3017-28. 2011
    ....
  10. ncbi request reprint Relationship between dyskerin expression and telomerase activity in human breast cancer
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italy
    Cell Oncol 30:483-90. 2008
    ..This should be taken into consideration when utilizing TERT expression as a surrogate indicator of telomerase activity in tumour pathology...
  11. ncbi request reprint Cell proliferation in breast cancer is a major determinant of clinical outcome in node-positive but not in node-negative patients
    Davide Trere
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Italy
    Appl Immunohistochem Mol Morphol 14:314-23. 2006
    ..Within this subgroup, the rapidity of cell proliferation as assessed by AgNOR analysis also served as a sensitive predictor of the response to adjuvant treatments...
  12. ncbi request reprint Evaluation of thymidylate synthase protein expression by Western blotting and immunohistochemistry on human colon carcinoma xenografts in nude mice
    Massimo Derenzini
    Department of Experimental Pathology, University of Bologna, Italy
    J Histochem Cytochem 50:1633-40. 2002
    ....
  13. pmc Cell proliferation of esophageal squamous epithelium in erosive and non-erosive reflux disease
    Carlo Calabrese
    Department of Clinical Medicine, University of Bologna, 40138 Bologna, Italy
    World J Gastroenterol 17:4496-502. 2011
    ..To elucidate cell proliferation in erosive reflux disease (ERD) and non-erosive reflux disease (NERD), we evaluated markers in squamous epithelial cells...
  14. ncbi request reprint Nucleolar size and activity are related to pRb and p53 status in human breast cancer
    Davide Trere
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    J Histochem Cytochem 52:1601-7. 2004
    ....
  15. pmc Nucleolus, ribosomes, and cancer
    Lorenzo Montanaro
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Am J Pathol 173:301-10. 2008
    ....
  16. ncbi request reprint Location of rRNA transcription to the nucleolar components: disappearance of the fibrillar centers in nucleoli of regenerating rat hepatocytes
    Lorenzo Montanaro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Cell Struct Funct 36:49-56. 2011
    ....
  17. ncbi request reprint Controversial relationship between the expression of the RB pathway components and RB protein phosphorylation in human breast cancer
    L Montanaro
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    Histol Histopathol 22:769-75. 2007
    ..Pathological increases of cyclin D, cdk4, and cyclin E are very likely associated with other biological functions other than their well-established action on cell cycle progression...
  18. doi request reprint High prevalence of retinoblastoma protein loss in triple-negative breast cancers and its association with a good prognosis in patients treated with adjuvant chemotherapy
    D Trere
    Department of Experimental Pathology, University of Bologna, Italy
    Ann Oncol 20:1818-23. 2009
    ..Since the retinoblastoma protein (pRb) loss confers a high sensitivity to chemotherapy regimens, we evaluated the prevalence of pRb loss in TNBCs and its relevance on the clinical outcome of patients treated with adjuvant chemotherapy...
  19. doi request reprint Ribosome biogenesis and control of cell proliferation: p53 is not alone
    Giulio Donati
    Department of Experimental Pathology, Alma Mater Studiorum, Universita di Bologna, Bologna, Italy
    Cancer Res 72:1602-7. 2012
    ....
  20. ncbi request reprint Increased mortality rate and not impaired ribosomal biogenesis is responsible for proliferative defect in dyskeratosis congenita cell lines
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita degli Studi di Bologna, Bologna, Italy
    J Invest Dermatol 118:193-8. 2002
    ....
  21. ncbi request reprint Nucleolar hypertrophy correlates with hepatocellular carcinoma development in cirrhosis due to HBV infection
    Davide Trere
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Italy
    Hepatology 37:72-8. 2003
    ....
  22. pmc The asialoglycoprotein receptor in human hepatocellular carcinomas: its expression on proliferating cells
    D Trere
    Servizio di Citopatologia, Policlinico S Orsola, and Dipartimento di Patologia Sperimentale, Universita di Bologna, Italy
    Br J Cancer 81:404-8. 1999
    ....
  23. pmc An innovative hyperbaric hypothermic machine perfusion protects the liver from experimental preservation injury
    Ferdinando A Giannone
    Department of Clinical Medicine, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy
    ScientificWorldJournal 2012:573410. 2012
    ..Thus, we test an innovative hyperbaric hypothermic machine perfusion (HHMP), which combines hyperbaric oxygenation of the preservation solution and continuous perfusion of the graft...
  24. ncbi request reprint Genetic pathways in the evolution of breast ductal carcinoma in situ
    Fulvia Farabegoli
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    J Pathol 196:280-6. 2002
    ..The evolution from DCIS to IDC may follow multiple pathways and not a linear model...
  25. ncbi request reprint Interferon plus ribavirin and interferon alone in preventing hepatocellular carcinoma: a prospective study on patients with HCV related cirrhosis
    Francesco Azzaroli
    Department of Internal Medicine, University of Bologna, Via Massarenti 9, 40138 Bologna
    World J Gastroenterol 10:3099-102. 2004
    ..Data on the preventive effect of IFN plus ribavirin treatment are lacking...
  26. ncbi request reprint Endoscopic appearance of GERD: putative role of cell proliferation
    C Calabrese
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Dig Liver Dis 39:713-9. 2007
    ..However, most of patients with heartburn/regurgitation have a non-erosive reflux disease. The reason for this heterogeneous impact of gastro-oesophageal reflux disease on oesophageal mucosa is unknown to date...
  27. ncbi request reprint Different effects of ribosome biogenesis inhibition on cell proliferation in retinoblastoma protein- and p53-deficient and proficient human osteosarcoma cell lines
    L Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italy
    Cell Prolif 40:532-49. 2007
    ..To evaluate the effects of rRNA synthesis inhibition on cell cycle progression and cell population growth according to the RB and p53 status...
  28. ncbi request reprint The AgNORs
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita degli Studi di Bologna, Italy
    Micron 31:117-20. 2000
    ..The "AgNOR" parameter has been proved to represent a reliable tool for defining the clinical outcome of cancer disease, being an independent prognostic factor in many types of tumors...
  29. ncbi request reprint c-erbB-2 over-expression in amplified and non-amplified breast carcinoma samples
    F Farabegoli
    Department of Experimental Pathology, University of Bologna, Italy
    Int J Cancer 84:273-7. 1999
    ..The combination of FISH and immuno-histochemistry may be helpful to achieve this aim...
  30. pmc Nucleolar function and size in cancer cells
    M Derenzini
    Department of Experimental Pathology, S Orsola Hospital, University of Bologna, Italy
    Am J Pathol 152:1291-7. 1998
    ..Quantitative distribution of nucleolar structures within the cell represents a cytohistological parameter of the rapidity of cell proliferation...
  31. pmc Thymidylate synthase protein expression and activity are related to the cell proliferation rate in human cancer cell lines
    M Derenzini
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126, Bologna, Italy
    Mol Pathol 55:310-4. 2002
    ..To ascertain whether the expression and enzyme activity of thymidylate synthase (TS) are related to the rapidity of cell proliferation in human cancer cell lines...
  32. ncbi request reprint Prognostic relevance of a novel semiquantitative classification of Bcl2 immunohistochemical expression in human infiltrating ductal carcinomas of the breast
    D Trere
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Italy
    Ann Oncol 18:1004-14. 2007
    ..In the present study, we evaluated the clinical relevance of a novel, semiquantitative classification of the Bcl2 immunostaining based on both the distribution and the intensity of the staining reaction...
  33. pmc The prognostic value of the AgNOR parameter in human breast cancer depends on the pRb and p53 status
    M Derenzini
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna 40126, Italy
    J Clin Pathol 57:755-61. 2004
    ..AgNOR expression is directly related to the rate of ribosome biogenesis, which has been recently shown to be controlled also by the tumour suppressor proteins pRb and p53...
  34. ncbi request reprint Nucleolar size indicates the rapidity of cell proliferation in cancer tissues
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Italy
    J Pathol 191:181-6. 2000
    ..Evaluation of nucleolar size after silver staining of AgNOR proteins represents a unique parameter for the histological assessment of rapidity of cell proliferation in tumour lesions...
  35. ncbi request reprint p120 expression provides a reliable indication of the rapidity of cell duplication in cancer cells independently of tumour origin
    D Trere
    Department of Experimental Pathology, University of Bologna, Italy
    J Pathol 192:216-20. 2000
    ..98, p<0.0001). These results indicate that in cancer cells, the quantitative expression of p120 is directly related to the rapidity of cell duplication, independently of the tumour origin...
  36. ncbi request reprint A statistical model predicting high hepatocyte proliferation index and the risk of developing hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis
    F Azzaroli
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Aliment Pharmacol Ther 24:129-36. 2006
    ..Incidence of hepatocellular carcinoma in hepatitis C virus-related cirrhosis is 4% per year. Although cost-effective, current screening could be improved...
  37. ncbi request reprint Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer
    L Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    J Pathol 210:10-8. 2006
    ..These data indicate that dyskerin is not lost in human cancers and that the levels of its expression and function are associated with tumour progression...
  38. pmc Enhanced telomere shortening in transformed lymphoblasts from patients with X linked dyskeratosis
    L Montanaro
    Universita degli Studi di Bologna, Dipartimento di Patologia Sperimentale, Via S Giacomo 14, 40126 Bologna, Italy
    J Clin Pathol 56:583-6. 2003
    ..This report aimed to verify whether this is caused by a defect in telomerase function...
  39. pmc Esophageal cell proliferation in gastroesophageal reflux disease: clinical-morphological data before and after pantoprazole
    Carlo Calabrese
    Department of Clinical Medicine, University of Bologna, Bologna, Italy
    World J Gastroenterol 15:936-41. 2009
    ....
  40. ncbi request reprint Prognostic relevance of silver-stained nucleolar proteins in sarcomatoid carcinomas of the breast
    V Eusebi
    Institute of Anatomic Pathology, University of Bologna, Italy
    Ultrastruct Pathol 15:203-14. 1991
    ..Patients who died early of the disease had a higher MNORA than patients who survived longer than 3 years. The difference was statistically significant. Ag-NORs might be a novel parameter of prognostic relevance in specific cases...
  41. pmc Prognostic relevance of pretreatment proliferative rapidity of marrow blast cells in childhood acute lymphoblastic leukaemia
    D Trere
    Centro di Patologia Cellulare, Dipartimento di Patologia Sperimentale, Bologna, Italy
    Br J Cancer 70:1198-202. 1994
    ..01). Our results indicate that the rapidity of marrow blast cell proliferation is an important prognostic parameter in childhood ALL and should be routinely introduced in the group risk definition...
  42. ncbi request reprint Relationship between interphase AgNOR distribution and nucleolar size in cancer cells
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Italy
    Histochem J 24:951-6. 1992
    ..These data indicate that evaluation of the interphase AgNOR area has the same relevance, in tumour pathology, as whole nucleolar size measurement...
  43. ncbi request reprint Bone hemangioendothelioma: an immunohistochemical study related to histological malignancy and proliferative activity (NORs)
    M S Benassi
    Laboratory of Oncologic Research, Rizzoli Orthopaedic Institute, Bologna, Italy
    Tumori 81:179-84. 1995
    ..CONCLUSIONS: The mean nucleolar organizer region (NOR) area, as a measure of cell proliferation, was significantly higher in grade 4 malignancies than in lower grades, revealing novel prognostic parameters...
  44. ncbi request reprint Liver-targeted doxorubicin: effects on rat regenerating hepatocytes
    Giuseppina Di Stefano
    Department of Experimental Pathology, University of Bologna, Via San Giacomo, Bologna, Italy
    Liver Int 24:246-52. 2004
    ....
  45. ncbi request reprint Diagnostic value of silver-stained interphasic nucleolar organizer regions in breast tumors
    M Derenzini
    Dipartimento di Patologia Sperimentale, University of Bologna Medical School, Italy
    Ultrastruct Pathol 14:233-45. 1990
    ..Furthermore, because there is evidence that MNORA values are indicative of the cell duplication rate, MNORA values may ultimately be considered an objective prognostic parameter in addition to grading for invasive ductal carcinomas...
  46. ncbi request reprint Coupling of 5-fluoro 2'-deoxyuridine to lactosaminated poly-l-lysine: an approach to a regional, non-invasive chemotherapy of liver micrometastases
    G Di Stefano
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126, Bologna, Italy
    Biochem Pharmacol 61:459-65. 2001
    ..The drug released from hepatic cells into liver blood following conjugate administration via the peripheral venous route might accomplish a locoregional, non-invasive treatment of micrometastases nourished by liver sinusoids...
  47. ncbi request reprint Selective staining of nucleic acids by osmium-ammine complex in thin sections from lowicryl-embedded samples
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Italy
    J Histochem Cytochem 38:1495-501. 1990
    ..Increasing the pH value of the staining medium resulted in loss of OA specificity for nucleic acids. The high electrolyte concentration of the staining medium hindered the staining reaction...