M Derenzini

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Nucleolar size indicates the rapidity of cell proliferation in cancer tissues
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Italy
    J Pathol 191:181-6. 2000
  2. ncbi Relationship between interphase AgNOR distribution and nucleolar size in cancer cells
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Italy
    Histochem J 24:951-6. 1992
  3. doi The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells
    G Donati
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italy
    Oncogene 30:3274-88. 2011
  4. ncbi Different effects of ribosome biogenesis inhibition on cell proliferation in retinoblastoma protein- and p53-deficient and proficient human osteosarcoma cell lines
    L Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italy
    Cell Prolif 40:532-49. 2007
  5. pmc The asialoglycoprotein receptor in human hepatocellular carcinomas: its expression on proliferating cells
    D Trere
    Servizio di Citopatologia, Policlinico S Orsola, and Dipartimento di Patologia Sperimentale, Universita di Bologna, Italy
    Br J Cancer 81:404-8. 1999
  6. pmc Prognostic relevance of pretreatment proliferative rapidity of marrow blast cells in childhood acute lymphoblastic leukaemia
    D Trere
    Centro di Patologia Cellulare, Dipartimento di Patologia Sperimentale, Bologna, Italy
    Br J Cancer 70:1198-202. 1994
  7. ncbi The AgNORs
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita degli Studi di Bologna, Italy
    Micron 31:117-20. 2000
  8. ncbi Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer
    L Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    J Pathol 210:10-8. 2006
  9. ncbi Selective staining of nucleic acids by osmium-ammine complex in thin sections from lowicryl-embedded samples
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Italy
    J Histochem Cytochem 38:1495-501. 1990
  10. ncbi Diagnostic value of silver-stained interphasic nucleolar organizer regions in breast tumors
    M Derenzini
    Dipartimento di Patologia Sperimentale, University of Bologna Medical School, Italy
    Ultrastruct Pathol 14:233-45. 1990

Detail Information

Publications21

  1. ncbi Nucleolar size indicates the rapidity of cell proliferation in cancer tissues
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Italy
    J Pathol 191:181-6. 2000
    ..Evaluation of nucleolar size after silver staining of AgNOR proteins represents a unique parameter for the histological assessment of rapidity of cell proliferation in tumour lesions...
  2. ncbi Relationship between interphase AgNOR distribution and nucleolar size in cancer cells
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Italy
    Histochem J 24:951-6. 1992
    ..These data indicate that evaluation of the interphase AgNOR area has the same relevance, in tumour pathology, as whole nucleolar size measurement...
  3. doi The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells
    G Donati
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italy
    Oncogene 30:3274-88. 2011
    ....
  4. ncbi Different effects of ribosome biogenesis inhibition on cell proliferation in retinoblastoma protein- and p53-deficient and proficient human osteosarcoma cell lines
    L Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italy
    Cell Prolif 40:532-49. 2007
    ..To evaluate the effects of rRNA synthesis inhibition on cell cycle progression and cell population growth according to the RB and p53 status...
  5. pmc The asialoglycoprotein receptor in human hepatocellular carcinomas: its expression on proliferating cells
    D Trere
    Servizio di Citopatologia, Policlinico S Orsola, and Dipartimento di Patologia Sperimentale, Universita di Bologna, Italy
    Br J Cancer 81:404-8. 1999
    ....
  6. pmc Prognostic relevance of pretreatment proliferative rapidity of marrow blast cells in childhood acute lymphoblastic leukaemia
    D Trere
    Centro di Patologia Cellulare, Dipartimento di Patologia Sperimentale, Bologna, Italy
    Br J Cancer 70:1198-202. 1994
    ..01). Our results indicate that the rapidity of marrow blast cell proliferation is an important prognostic parameter in childhood ALL and should be routinely introduced in the group risk definition...
  7. ncbi The AgNORs
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita degli Studi di Bologna, Italy
    Micron 31:117-20. 2000
    ..The "AgNOR" parameter has been proved to represent a reliable tool for defining the clinical outcome of cancer disease, being an independent prognostic factor in many types of tumors...
  8. ncbi Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer
    L Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    J Pathol 210:10-8. 2006
    ..These data indicate that dyskerin is not lost in human cancers and that the levels of its expression and function are associated with tumour progression...
  9. ncbi Selective staining of nucleic acids by osmium-ammine complex in thin sections from lowicryl-embedded samples
    M Derenzini
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Italy
    J Histochem Cytochem 38:1495-501. 1990
    ..Increasing the pH value of the staining medium resulted in loss of OA specificity for nucleic acids. The high electrolyte concentration of the staining medium hindered the staining reaction...
  10. ncbi Diagnostic value of silver-stained interphasic nucleolar organizer regions in breast tumors
    M Derenzini
    Dipartimento di Patologia Sperimentale, University of Bologna Medical School, Italy
    Ultrastruct Pathol 14:233-45. 1990
    ..Furthermore, because there is evidence that MNORA values are indicative of the cell duplication rate, MNORA values may ultimately be considered an objective prognostic parameter in addition to grading for invasive ductal carcinomas...
  11. ncbi Relationship between the RB1 mRNA level and the expression of phosphorylated RB protein in human breast cancers: their relevance in cell proliferation activity and patient clinical outcome
    M Derenzini
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    Histol Histopathol 22:505-13. 2007
    ....
  12. ncbi Prognostic relevance of a novel semiquantitative classification of Bcl2 immunohistochemical expression in human infiltrating ductal carcinomas of the breast
    D Trere
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Italy
    Ann Oncol 18:1004-14. 2007
    ..In the present study, we evaluated the clinical relevance of a novel, semiquantitative classification of the Bcl2 immunostaining based on both the distribution and the intensity of the staining reaction...
  13. ncbi Controversial relationship between the expression of the RB pathway components and RB protein phosphorylation in human breast cancer
    L Montanaro
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    Histol Histopathol 22:769-75. 2007
    ..Pathological increases of cyclin D, cdk4, and cyclin E are very likely associated with other biological functions other than their well-established action on cell cycle progression...
  14. ncbi Endoscopic appearance of GERD: putative role of cell proliferation
    C Calabrese
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Dig Liver Dis 39:713-9. 2007
    ..However, most of patients with heartburn/regurgitation have a non-erosive reflux disease. The reason for this heterogeneous impact of gastro-oesophageal reflux disease on oesophageal mucosa is unknown to date...
  15. ncbi Bone hemangioendothelioma: an immunohistochemical study related to histological malignancy and proliferative activity (NORs)
    M S Benassi
    Laboratory of Oncologic Research, Rizzoli Orthopaedic Institute, Bologna, Italy
    Tumori 81:179-84. 1995
    ..CONCLUSIONS: The mean nucleolar organizer region (NOR) area, as a measure of cell proliferation, was significantly higher in grade 4 malignancies than in lower grades, revealing novel prognostic parameters...
  16. ncbi A statistical model predicting high hepatocyte proliferation index and the risk of developing hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis
    F Azzaroli
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Aliment Pharmacol Ther 24:129-36. 2006
    ..Incidence of hepatocellular carcinoma in hepatitis C virus-related cirrhosis is 4% per year. Although cost-effective, current screening could be improved...
  17. pmc Erosions or not in GORD? The potential role of oesophageal cell proliferation
    C Calabrese
    Gut 54:887-8. 2005
  18. pmc The prognostic value of the AgNOR parameter in human breast cancer depends on the pRb and p53 status
    M Derenzini
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna 40126, Italy
    J Clin Pathol 57:755-61. 2004
    ..AgNOR expression is directly related to the rate of ribosome biogenesis, which has been recently shown to be controlled also by the tumour suppressor proteins pRb and p53...
  19. pmc Thymidylate synthase protein expression and activity are related to the cell proliferation rate in human cancer cell lines
    M Derenzini
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126, Bologna, Italy
    Mol Pathol 55:310-4. 2002
    ..To ascertain whether the expression and enzyme activity of thymidylate synthase (TS) are related to the rapidity of cell proliferation in human cancer cell lines...
  20. pmc Enhanced telomere shortening in transformed lymphoblasts from patients with X linked dyskeratosis
    L Montanaro
    Universita degli Studi di Bologna, Dipartimento di Patologia Sperimentale, Via S Giacomo 14, 40126 Bologna, Italy
    J Clin Pathol 56:583-6. 2003
    ..This report aimed to verify whether this is caused by a defect in telomerase function...
  21. ncbi Coupling of 5-fluoro 2'-deoxyuridine to lactosaminated poly-l-lysine: an approach to a regional, non-invasive chemotherapy of liver micrometastases
    G Di Stefano
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126, Bologna, Italy
    Biochem Pharmacol 61:459-65. 2001
    ..The drug released from hepatic cells into liver blood following conjugate administration via the peripheral venous route might accomplish a locoregional, non-invasive treatment of micrometastases nourished by liver sinusoids...