Mario dell'Agli

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. doi request reprint Plant food supplements with anti-inflammatory properties: a systematic review (I)
    Mario dell'Agli
    Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Via Balzaretti, Milano, Italy
    Crit Rev Food Sci Nutr 53:403-13. 2013
  2. pmc Anti-plasmodial and insecticidal activities of the essential oils of aromatic plants growing in the Mediterranean area
    Mario dell'Agli
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Milan, Italy
    Malar J 11:219. 2012
  3. doi request reprint Potent inhibition of human phosphodiesterase-5 by icariin derivatives
    Mario dell'Agli
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    J Nat Prod 71:1513-7. 2008
  4. doi request reprint Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kappaB signaling
    Mario dell'Agli
    Research Centre for the Characterization and Safe Use of Natural Compounds Giovanni Galli, University of Milano, Via Balzaretti, 9, 20133 Milano, Italy
    J Agric Food Chem 58:2246-52. 2010
  5. doi request reprint Antiplasmodial activity of Punica granatum L. fruit rind
    Mario dell'Agli
    Department of Pharmacological Sciences, University of Camerino, Italy
    J Ethnopharmacol 125:279-85. 2009
  6. doi request reprint Inhibition of NF-kB and metalloproteinase-9 expression and secretion by parthenolide derivatives
    Mario dell'Agli
    Department of Pharmacological Sciences, University of Milan, Italy
    Bioorg Med Chem Lett 19:1858-60. 2009
  7. doi request reprint Anti-plasmodial activity of Ailanthus excelsa
    Mario dell'Agli
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Fitoterapia 79:112-6. 2008
  8. pmc Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria
    Mario dell'Agli
    Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, Via Balzaretti, 9 20133 Milano, Italy
    Malar J 9:208. 2010
  9. ncbi request reprint Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase
    Mario dell'Agli
    Research Centre for the Characterization and Safe use of Natural Compounds, Giovanni Galli, Department of Pharmacological Sciences, University of Milan, Italy
    Br J Nutr 99:945-51. 2008
  10. ncbi request reprint Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation
    Mario dell'Agli
    Department of Pharmacological Sciences, University of Milan, Italy
    J Agric Food Chem 54:3259-64. 2006

Collaborators

Detail Information

Publications33

  1. doi request reprint Plant food supplements with anti-inflammatory properties: a systematic review (I)
    Mario dell'Agli
    Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Via Balzaretti, Milano, Italy
    Crit Rev Food Sci Nutr 53:403-13. 2013
    ..was selected. In conclusion, it is advisable to conduct further studies with more homogeneous population and larger number of subjects by avoiding the heterogeneity of the herbal preparations considered...
  2. pmc Anti-plasmodial and insecticidal activities of the essential oils of aromatic plants growing in the Mediterranean area
    Mario dell'Agli
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Milan, Italy
    Malar J 11:219. 2012
    ....
  3. doi request reprint Potent inhibition of human phosphodiesterase-5 by icariin derivatives
    Mario dell'Agli
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    J Nat Prod 71:1513-7. 2008
    ..The improved pharmacodynamic profile and lack of cytotoxicity on human fibroblasts make compound 5 a promising candidate for further development...
  4. doi request reprint Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kappaB signaling
    Mario dell'Agli
    Research Centre for the Characterization and Safe Use of Natural Compounds Giovanni Galli, University of Milano, Via Balzaretti, 9, 20133 Milano, Italy
    J Agric Food Chem 58:2246-52. 2010
    ..Our findings provide further evidence on the mechanisms by which olive oil reduces the inflammatory burden associated with disorders, such as atherosclerosis...
  5. doi request reprint Antiplasmodial activity of Punica granatum L. fruit rind
    Mario dell'Agli
    Department of Pharmacological Sciences, University of Camerino, Italy
    J Ethnopharmacol 125:279-85. 2009
    ..Urolithins, the ellagitannin metabolites, were also investigated for antiplasmodial activity...
  6. doi request reprint Inhibition of NF-kB and metalloproteinase-9 expression and secretion by parthenolide derivatives
    Mario dell'Agli
    Department of Pharmacological Sciences, University of Milan, Italy
    Bioorg Med Chem Lett 19:1858-60. 2009
    ..Then an increased ability of the 5 and 6 to inhibit NF-kB driven transcription may lead to a down-regulation of MMP-9 expression and secretion. This work provides new details about the structural requisites for NF-kB inhibition...
  7. doi request reprint Anti-plasmodial activity of Ailanthus excelsa
    Mario dell'Agli
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Fitoterapia 79:112-6. 2008
    ..The anti-plasmodial activity could be ascribed to the impairment of haemoglobin degradation through the inhibition of plasmepsin II activity (IC50 of 13.43+/-1.74 microg/ml) and of the haem detoxification to haemozoin...
  8. pmc Ellagitannins of the fruit rind of pomegranate (Punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria
    Mario dell'Agli
    Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, Via Balzaretti, 9 20133 Milano, Italy
    Malar J 9:208. 2010
    ..The aim of the present study was to explore whether the anti-malarial effect of OMARIA could also be sustained via other mechanisms among those associated to the host immune response...
  9. ncbi request reprint Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase
    Mario dell'Agli
    Research Centre for the Characterization and Safe use of Natural Compounds, Giovanni Galli, Department of Pharmacological Sciences, University of Milan, Italy
    Br J Nutr 99:945-51. 2008
    ..Olive oil extracts and part of its phenolic constituents inhibit platelet aggregation; cAMP-PDE inhibition is one mechanism through which olive oil phenols inhibit platelet aggregation...
  10. ncbi request reprint Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation
    Mario dell'Agli
    Department of Pharmacological Sciences, University of Milan, Italy
    J Agric Food Chem 54:3259-64. 2006
    ..These results supply new insights on the protective role of olive oil against vascular risk through the down-regulation of adhesion molecules involved in early atherogenesis...
  11. ncbi request reprint Inhibition of cGMP-phosphodiesterase-5 by biflavones of Ginkgo biloba
    Mario dell'Agli
    Department of Pharmacological Sciences, Faculty of Pharmacy, Milan, Italy
    Planta Med 72:468-70. 2006
    ..These data suggest that GBDF could exert a vasodilating effect through a mechanism independent of NO release...
  12. ncbi request reprint In vitro inhibition of human cGMP-specific phosphodiesterase-5 by polyphenols from red grapes
    Mario dell'Agli
    Department of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Agric Food Chem 53:1960-5. 2005
    ..These results indicate that polyphenols-induced vasorelaxation may also be sustained by smooth muscle PDE inhibition by anthocyanins present in red wines and grapes...
  13. ncbi request reprint Vascular effects of wine polyphenols
    Mario dell'Agli
    Faculty of Pharmacy, Department of Pharmacological Sciences, Via Balzaretti, 9 20133 Milan, Italy
    Cardiovasc Res 63:593-602. 2004
    ..Moreover, they inhibit platelet aggregation. However, a paucity of data as regards the bioavailability and metabolism of these compounds in human studies is a limiting factor to proving their efficacy in vivo...
  14. ncbi request reprint High antiplasmodial activity of novel plasmepsins I and II inhibitors
    Mario dell'Agli
    Department of Pharmacological Sciences, School of Pharmacy, University of Milan, Milan 20100, Italy
    J Med Chem 49:7440-9. 2006
    ..The most promising compounds (2, 6, 10) were not cytotoxic against human fibroblasts at 100 microM and were highly selective for PLMs vs human cathepsin D...
  15. ncbi request reprint Atovaquone-statine "double-drugs" with high antiplasmodial activity
    Sergio Romeo
    Institute of Medicinal Chemistry Pietro Pratesi, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    ChemMedChem 3:418-20. 2008
  16. ncbi request reprint Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs'
    Sergio Romeo
    Institute of Medicinal Chemistry, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
    Bioorg Med Chem Lett 14:2931-4. 2004
    ..59 to 400 nM and the best IC50 value for inhibition of Plasmodium falciparum growth in vitro was 0.4 microM, which represent a remarkable improvement compared to other statine-based PLMII inhibitors...
  17. doi request reprint Plant food supplements with anti-inflammatory properties: a systematic review (II)
    Chiara Di Lorenzo
    Department of Pharmacological and Biomolecular Sciences, Universit à degli Studi di Milano, Via Balzaretti 9, Milano, Italy
    Crit Rev Food Sci Nutr 53:507-16. 2013
    ..In conclusion, it is advisable to conduct further studies with more homogeneous population and larger number of subjects by avoiding the heterogeneity of the herbal preparations considered...
  18. doi request reprint In vitro characterization of the immunotoxic potential of several perfluorinated compounds (PFCs)
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
    Toxicol Appl Pharmacol 258:248-55. 2012
    ..Our results indicate that PFOA is the least active of the PFCs examined followed by PFBS, PFDA, PFOS, PFOSA and fluorotelomer...
  19. doi request reprint Antiplasmodial activities of 4-aminoquinoline-statine compounds
    Nadia Vaiana
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy
    Bioorg Med Chem Lett 22:5915-8. 2012
    ..Some of the molecules were more active than CQ against CQ-resistant strain and showed good selectivity against cathepsin D...
  20. doi request reprint Inhibition of neutrophil elastase and metalloprotease-9 of human adenocarcinoma gastric cells by chamomile (Matricaria recutita L.) infusion
    Michela Bulgari
    Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, Milan, Italy
    Phytother Res 26:1817-22. 2012
    ..The results further indicate that the flavonoid-7-glycosides, major constituents of chamomile flowers, may be responsible for the antiinflammatory action of the chamomile infusion observed here...
  21. doi request reprint Inhibition of human cAMP-phosphodiesterase as a mechanism of the spasmolytic effect of Matricaria recutita L
    Omar Maschi
    Research Centre for the Characterization and Safe Use of Natural Compounds Giovanni Galli, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    J Agric Food Chem 56:5015-20. 2008
    ..Although experimental evidence supporting the use of chamomile for gastrointestinal minor spasms dates back to the fifties, cAMP-PDE inhibition as a likely mechanism underlying the spasmolytic activity is reported for the first time...
  22. doi request reprint Inhibition of NF- κB activity by minor polar components of extra-virgin olive oil at gastric level
    Enrico Sangiovanni
    Department of Pharmacological Sciences, Universita degli Studi di Milano, Milano, Italy
    Phytother Res 26:1569-71. 2012
    ..All the compounds under study inhibited nuclear translocation as well. The data suggest that consumption of extra-virgin olive oil may be beneficial for preventing the onset of gastric inflammation leading to more serious diseases...
  23. ncbi request reprint Biflavones of Ginkgo biloba stimulate lipolysis in 3T3-L1 adipocytes
    Mario dell'Agli
    Department of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, Milan, Italy
    Planta Med 68:76-9. 2002
    ..Maximal stimulation was observed at 0.1 - 0.5 microM. At higher concentrations the effect diminished progressively and was lost at 100 microM. Only a partial loss of cell viability was observed with biflavones at 10 - 100 microM...
  24. doi request reprint Correlation between catechin content and NF-κB inhibition by infusions of green and black tea
    Chiara Di Lorenzo
    Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy
    Plant Foods Hum Nutr 68:149-54. 2013
    ..This is the first paper reporting the inhibitory effect of NF-κB of commercial green and black infusions at the gastric level, evaluating their stability as well...
  25. ncbi request reprint Dietary polyphenols and regulation of gelatinase expression and activity
    Mario dell'Agli
    Department of Pharmacological Sciences, Via Balzaretti 9, 20133 Milan, Italy
    Thromb Haemost 93:751-60. 2005
    ..Therefore, they could have a beneficial effect in many pathological conditions implicated in connective tissue destruction and remodelling associated with degenerative diseases...
  26. pmc Ellagitannins from Rubus berries for the control of gastric inflammation: in vitro and in vivo studies
    Enrico Sangiovanni
    Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Via Balzaretti, Milano, Italy
    PLoS ONE 8:e71762. 2013
    ..The results of the present study report for the first time the preventing effect of ETs in gastric inflammation and support for their use in dietary regimens against peptic ulcer...
  27. pmc Metabolic syndrome and inflammation: a critical review of in vitro and clinical approaches for benefit assessment of plant food supplements
    Chiara Di Lorenzo
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Evid Based Complement Alternat Med 2013:782461. 2013
    ....
  28. doi request reprint Enterodiol and enterolactone modulate the immune response by acting on nuclear factor-kappaB (NF-kappaB) signaling
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
    J Agric Food Chem 58:6678-84. 2010
    ..EL and ED were also able to pass the intestinal barrier and modulate cytokine production. The findings of the present study reveal potential mechanisms that could explain some in vivo beneficial effects of lignans...
  29. doi request reprint Antiplasmodial and anti-inflammatory activities of Canthium henriquesianum (K. Schum), a plant used in traditional medicine in Burkina Faso
    Denise P Ilboudo
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Via Pascal 36, 20133 Milan, Italy
    J Ethnopharmacol 148:763-9. 2013
    ..Schum). In parallel, extracts of Gardenia sokotensis (Hutch) and Vernonia colorata (Willd), also traditionally used together in Burkina Faso and already reported with antimalarial activity, were compared...
  30. doi request reprint In vitro evaluation of the immunotoxic potential of perfluorinated compounds (PFCs)
    Emanuela Corsini
    Laboratory of Toxicology, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
    Toxicol Appl Pharmacol 250:108-16. 2011
    ..Overall, these studies suggest that PFCs directly suppress cytokine secretion by immune cells, and that PFOA and PFOS have different mechanisms of action...
  31. pmc A review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract
    Elisa Colombo
    Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Via Balzaretti 9, Milano, Italy
    Evid Based Complement Alternat Med 2013:247145. 2013
    ..No clinical studies have been found, thus suggesting that future clinical studies are necessary to clarify the beneficial effects of pomegranate in the gastrointestinal tract...
  32. doi request reprint Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine
    Raffaella Molteni
    Dipartimento di Scienze Farmacologiche e Biomolecolari, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Eur Neuropsychopharmacol 23:1645-55. 2013
    ....
  33. doi request reprint Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease
    Roberta Epis
    Department of Pharmacological Sciences and Centre of Excellence on Neurodegenerative Diseases, Universita degli Studi di Milano, 20133 Milan, Italy
    Brain 133:3323-35. 2010
    ..Behavioural and electrophysiological deficits were also induced by peptide treatment...