Domenico Vittorio Delfino

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. ncbi request reprint Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice
    Domenico Vittorio Delfino
    Section of Pharmacology, Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Blood 104:4134-41. 2004
  2. ncbi request reprint Inhibited cell death, NF-kappaB activity and increased IL-10 in TCR-triggered thymocytes of transgenic mice overexpressing the glucocorticoid-induced protein GILZ
    Domenico Vittorio Delfino
    Section of Pharmacology, Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Int Immunopharmacol 6:1126-34. 2006
  3. pmc Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes
    D V Delfino
    Section of Pharmacology Toxicology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Cell Death Differ 18:183-90. 2011
  4. ncbi request reprint Manipulating thymic apoptosis for future therapy of autoimmune diseases
    Domenico V Delfino
    Section of Pharmacology, Toxicology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Curr Pharm Des 17:3108-19. 2011
  5. ncbi request reprint Dexamethasone-induced thymocytes apoptosis requires glucocorticoid receptor nuclear translocation but not mitochondrial membrane potential transition
    Maria Cristina Marchetti
    Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Toxicol Lett 139:175-80. 2003

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice
    Domenico Vittorio Delfino
    Section of Pharmacology, Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Blood 104:4134-41. 2004
    ..These results support the hypothesis that GILZ participates in the regulation of thymocyte apoptosis by glucocorticoids...
  2. ncbi request reprint Inhibited cell death, NF-kappaB activity and increased IL-10 in TCR-triggered thymocytes of transgenic mice overexpressing the glucocorticoid-induced protein GILZ
    Domenico Vittorio Delfino
    Section of Pharmacology, Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Int Immunopharmacol 6:1126-34. 2006
    ..These results support the hypothesis that GILZ regulates, at least in part, T-cell development by influencing thymus function at cellular and molecular levels...
  3. pmc Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes
    D V Delfino
    Section of Pharmacology Toxicology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
    Cell Death Differ 18:183-90. 2011
    ..In summary, our results suggest that caspase-8 activation protects Gilz from proteasomal degradation and induces its binding to SUMO-1 in GC-treated thymocytes...
  4. ncbi request reprint Manipulating thymic apoptosis for future therapy of autoimmune diseases
    Domenico V Delfino
    Section of Pharmacology, Toxicology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Curr Pharm Des 17:3108-19. 2011
    ..Future therapeutic strategies for autoimmune diseases should exploit manipulations in the negative selection process and/or the differentiation of Treg cells in the thymus...
  5. ncbi request reprint Dexamethasone-induced thymocytes apoptosis requires glucocorticoid receptor nuclear translocation but not mitochondrial membrane potential transition
    Maria Cristina Marchetti
    Department of Clinical and Experimental Medicine, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Toxicol Lett 139:175-80. 2003
    ..These data indicate many biochemical events and are activated by DEX treatment of thymocytes and some, but not all, are required for apoptosis...