P Defilippi

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi {beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation
    Paola Defilippi
    Department of Genetics, Biology and Biochemistry, University of Torino, 10126, Torino, Italy
    J Cell Biol 168:1099-108. 2005
  2. ncbi p130Cas: a versatile scaffold in signaling networks
    Paola Defilippi
    Department of Genetics, Biology and Biochemistry, University of Turin, Via Santena 5 bis 10126 Turin, Italy
    Trends Cell Biol 16:257-63. 2006
  3. ncbi The winding road from adhesive receptors to the nucleus. Conference on molecular biology of cellular interactions: adhesion receptor signalling and regulation of gene expression
    Paola Defilippi
    Dipartimento di Genetica, Biologia e Biochimica, Sezione di Biologia, , Via Santena 5 bis, 10126, Torino, Italy
    EMBO Rep 3:312-6. 2002
  4. ncbi Actin cytoskeleton organization in response to integrin-mediated adhesion
    P Defilippi
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Torino, Italy
    Microsc Res Tech 47:67-78. 1999
  5. ncbi Dissection of pathways implicated in integrin-mediated actin cytoskeleton assembly. Involvement of protein kinase C, Rho GTPase, and tyrosine phosphorylation
    P Defilippi
    Dipartimento di Genetica, Biologia e Chimica Medica, Universita di Torino, 10126 Torino, Italy
    J Biol Chem 272:21726-34. 1997
  6. ncbi Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activity
    S F Retta
    Department of Genetics, Biology and Medical Chemistry, University of Torino, Torino, 10126, Italy
    Exp Cell Res 229:307-17. 1996
  7. ncbi p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation
    L Damiano
    Molecular Biotechnology Centre, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy
    Oncogene 31:624-33. 2012
  8. ncbi p125FAK tyrosine phosphorylation and focal adhesion assembly: studies with phosphotyrosine phosphatase inhibitors
    P Defilippi
    Dipartimento di Genetica, Biologia e Chimica Medica, Universita di Torino, Italy
    Exp Cell Res 221:141-52. 1995
  9. ncbi β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells
    V Morello
    Molecular Biotechnology Center, University of Torino, Italy
    Oncogene 30:4087-96. 2011
  10. ncbi p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation
    L Damiano
    Molecular Biotechnology Centre and Department of Genetics, Biology and Biochemistry, Torino, Italy
    Oncogene 29:3677-90. 2010

Collaborators

Detail Information

Publications30

  1. ncbi {beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation
    Paola Defilippi
    Department of Genetics, Biology and Biochemistry, University of Torino, 10126, Torino, Italy
    J Cell Biol 168:1099-108. 2005
    ..Therefore, these data provide strong evidence that integrin-dependent STAT5A activation controls IL-3-mediated proliferation...
  2. ncbi p130Cas: a versatile scaffold in signaling networks
    Paola Defilippi
    Department of Genetics, Biology and Biochemistry, University of Turin, Via Santena 5 bis 10126 Turin, Italy
    Trends Cell Biol 16:257-63. 2006
    ..Here, we discuss recent developments that highlight a fundamental role in cell transformation and microbial pathogenesis and the implications of these developments on p130Cas function under normal and pathological conditions...
  3. ncbi The winding road from adhesive receptors to the nucleus. Conference on molecular biology of cellular interactions: adhesion receptor signalling and regulation of gene expression
    Paola Defilippi
    Dipartimento di Genetica, Biologia e Biochimica, Sezione di Biologia, , Via Santena 5 bis, 10126, Torino, Italy
    EMBO Rep 3:312-6. 2002
  4. ncbi Actin cytoskeleton organization in response to integrin-mediated adhesion
    P Defilippi
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Torino, Italy
    Microsc Res Tech 47:67-78. 1999
    ....
  5. ncbi Dissection of pathways implicated in integrin-mediated actin cytoskeleton assembly. Involvement of protein kinase C, Rho GTPase, and tyrosine phosphorylation
    P Defilippi
    Dipartimento di Genetica, Biologia e Chimica Medica, Universita di Torino, 10126 Torino, Italy
    J Biol Chem 272:21726-34. 1997
    ....
  6. ncbi Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activity
    S F Retta
    Department of Genetics, Biology and Medical Chemistry, University of Torino, Torino, 10126, Italy
    Exp Cell Res 229:307-17. 1996
    ....
  7. ncbi p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation
    L Damiano
    Molecular Biotechnology Centre, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy
    Oncogene 31:624-33. 2012
    ..Taken together, these data demonstrate that p140Cap suppresses the invasive properties of highly metastatic breast carcinoma cells by inhibiting cortactin-dependent cell motility...
  8. ncbi p125FAK tyrosine phosphorylation and focal adhesion assembly: studies with phosphotyrosine phosphatase inhibitors
    P Defilippi
    Dipartimento di Genetica, Biologia e Chimica Medica, Universita di Torino, Italy
    Exp Cell Res 221:141-52. 1995
    ..Based on these data we suggest that assembly of actin cytoskeleton plays an important role in inhibiting PTPases involved in p125FAK tyrosine phosphorylation...
  9. ncbi β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells
    V Morello
    Molecular Biotechnology Center, University of Torino, Italy
    Oncogene 30:4087-96. 2011
    ..Overall, these results show that β1 integrin is an essential regulator of EGFR signaling and tumorigenic properties of lung cancer cells, and that its silencing might represent an adjuvant approach to anti-EGFR therapy...
  10. ncbi p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation
    L Damiano
    Molecular Biotechnology Centre and Department of Genetics, Biology and Biochemistry, Torino, Italy
    Oncogene 29:3677-90. 2010
    ..Therefore, p140Cap mechanistically behaves as a tumour suppressor that inhibits signalling pathways leading to aggressive phenotypes...
  11. ncbi Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cells
    P Defilippi
    Department of Genetics, Biology and Medical Chemistry, University of Torino, Italy
    J Cell Biol 114:855-63. 1991
    ..The alpha 1 integrin is thus a marker of a specific population of endothelial cells and its expression confers distinctive properties of interaction with the underlying basal membrane...
  12. ncbi Expression of receptors for extracellular matrix proteins in human endothelial cells
    G Tarone
    Dipartimento di Genetica, Biologia e Chimica Medica, , Turin, Italy
    J Lipid Mediat 2:S45-53. 1990
    ..HEC cells thus express receptors for several matrix components and inflammatory mediators such as TNF alpha and IFN-gamma can selectively alter the expression of some of them...
  13. ncbi Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2
    R Soldi
    Institute for Cancer Research and Treatment IRCC, Biology and Biochemistry, School of Medicine, University of Torino, 10100 Torino, Italy
    EMBO J 18:882-92. 1999
    ....
  14. ncbi Integrin regulation of epidermal growth factor (EGF) receptor and of EGF-dependent responses
    S Cabodi
    Dipartimento di Genetica, Biologia e Biochimica, , Via Santena 5 bis, 10126 Torino, Italy
    Biochem Soc Trans 32:438-42. 2004
    ....
  15. ncbi Inhibition of β1 integrin and IL-3Rβ common subunit interaction hinders tumour angiogenesis
    B Uberti
    Department of Internal Medicine, University of Turin, Turin, Italy
    Oncogene 29:6581-90. 2010
    ..In conclusion, these data identify the β1 integrin-interacting domain in the juxta-membrane IL-3Rβc extracellular domain, and provide the rational for targeting this interaction to impair vascular growth...
  16. ncbi Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression
    Sara Cabodi
    Centro di Biotecnologie Molecolari and Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Torino, Italy
    J Cell Physiol 218:294-303. 2009
    ..These data demonstrate that integrin/EGFR cross-talk is required for expression of Egr-1 through a novel regulatory cascade involving the activation of the PI3K/Akt/Forkhead pathway...
  17. ncbi P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading
    Paola Di Stefano
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, 10126 Turin, Italy
    Mol Biol Cell 15:787-800. 2004
    ....
  18. ncbi STAT5 activation induced by diabetic LDL depends on LDL glycation and occurs via src kinase activity
    Maria Felice Brizzi
    Department of Internal Medicine, University of Torino, Torino, Italy
    Diabetes 51:3311-7. 2002
    ..Collectively, our results provide evidence for the role of glycation in dm-LDL-mediated effects and for a specific role of src kinase in STAT5-dependent p21(waf) expression...
  19. ncbi p130Cas mediates the transforming properties of the anaplastic lymphoma kinase
    Chiara Ambrogio
    Center for Experimental Research and Medical Studies and Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Blood 106:3907-16. 2005
    ....
  20. ncbi Integrins and signal transduction
    Sara Cabodi
    Molecular and Biotechnology Center and Department of Genetics, Biology and Biochemistry, University of Torino, Via Nizza 52, 10126 Torino, Italy
    Adv Exp Med Biol 674:43-54. 2010
    ....
  21. ncbi p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity
    Paola Di Stefano
    Molecular Biotechnology Center, University of Torino, Via Nizza 52, Turin 10126, Italy
    EMBO J 26:2843-55. 2007
    ..Moreover, cell proliferation and "in vivo" breast cancer cell growth are strongly impaired by high levels of p140Cap, providing the first evidence that p140Cap is a novel negative regulator of tumour growth...
  22. ncbi p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells
    Sara Cabodi
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Via Santena 5 bis, 10126 Turin, Italy
    J Cell Sci 117:1603-11. 2004
    ..Therefore, our data show that the adaptor protein p130Cas associates with the estrogen receptor transducing complex, regulating estrogen-dependent activation of c-Src kinase and downstream signaling pathways...
  23. ncbi p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis
    Sara Cabodi
    Department of Genetics, Biology and Biochemistry, University of Torino, Italy
    Cancer Res 66:4672-80. 2006
    ..Its overexpression contributes to HER2-Neu-induced breast tumorigenesis, thus identifying this protein as a putative target for clinical therapy...
  24. ncbi p130Cas is an essential transducer element in ErbB2 transformation
    Sara Cabodi
    Molecular Biotechnology Center, University of Torino, Torino, Via Nizza 52, 10126 Torino, Italy
    FASEB J 24:3796-808. 2010
    ..These results demonstrate that p130Cas is an essential transducer in ErbB2 transformation and highlight its potential use as a novel therapeutic target in ErbB2 positive human breast cancers...
  25. ncbi Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines
    Laura Moro
    Dipartimento di Scienze Mediche, , Novara 28100, Italy
    J Biol Chem 277:9405-14. 2002
    ..Therefore these data indicate that integrin-mediated adhesion induces assembly of a macromolecular complex containing c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosine residues...
  26. ncbi Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling
    Alessia Cherubini
    Department of Experimental Pathology and Oncology, University of Firenze, 50134 Firenze, Italy
    Mol Biol Cell 16:2972-83. 2005
    ..Similarly, the activity of the small GTPase Rac1 turned out to be dependent on hERG currents. On the whole, these data indicate that the hERG1 protein associates with beta(1) integrins and modulates adhesion receptor signaling...
  27. ncbi The interaction between KDR and interleukin-3 receptor (IL-3R) beta common modulates tumor neovascularization
    Patrizia Dentelli
    Department of Internal Medicine University of Torino, Corso Dogliotti 14, Torino 10126, Italy
    Oncogene 24:6394-405. 2005
    ..Thus, these findings provide a novel mechanism through which IL-3 and VEGF support cell survival and tumor neovascularization...
  28. ncbi Systematic analysis of the epidermal growth factor receptor by mass spectrometry reveals stimulation-dependent multisite phosphorylation
    Elisabetta Boeri Erba
    Protein Research Group, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark
    Mol Cell Proteomics 4:1107-21. 2005
    ..This MALDI MS/MS-based analytical approach demonstrates the feasibility of systematic analysis of signaling molecules by mass spectrometry and provides new insights into the dynamics of receptor signaling processes...
  29. ncbi Nongenomic effects of 17beta-estradiol in human platelets: potentiation of thrombin-induced aggregation through estrogen receptor beta and Src kinase
    Laura Moro
    Department of Medical Sciences, DiSCAFF, University A Avogadro, Novara, Italy
    Blood 105:115-21. 2005
    ..Taken together, these results indicate that 17beta-estradiol can modulate platelet function by exercising a proaggregating role...
  30. ncbi Quantitation of multisite EGF receptor phosphorylation using mass spectrometry and a novel normalization approach
    Elisabetta Boeri Erba
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    J Proteome Res 6:2768-85. 2007
    ..Furthermore, our results suggest that strong phosphatase inhibitors should be used to generate reference datasets in comparative phosphoproteomics experiments...