Giovanni Defazio

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. pmc Influence of coffee drinking and cigarette smoking on the risk of primary late onset blepharospasm: evidence from a multicentre case control study
    G Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 78:877-9. 2007
  2. pmc Development and validation of a clinical guideline for diagnosing blepharospasm
    Giovanni Defazio
    Department of Basic Medical Sciences, Neurosciences and Sense organs, Aldo Moro University of Bari, Italy
    Neurology 81:236-40. 2013
  3. doi request reprint Tremor in primary adult-onset dystonia: prevalence and associated clinical features
    Giovanni Defazio
    Department of Neuroscience and Sensory Organs, Aldo Moro University of Bari, Piazza Giulio Cesare, Bari 2 70124, Italy
    J Neurol Neurosurg Psychiatry 84:404-8. 2013
  4. doi request reprint Phenotypic overlap in familial and sporadic primary adult-onset extracranial dystonia
    Giovanni Defazio
    Department of Neurosciences and Sensory Organs, School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy
    J Neurol 259:2414-8. 2012
  5. doi request reprint Eye symptoms in relatives of patients with primary adult-onset dystonia
    Giovanni Defazio
    Department of Neurosciences and Sensory Organs, School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy
    Mov Disord 27:305-7. 2012
  6. ncbi request reprint Primary blepharospasm: diagnosis and management
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Drugs 64:237-44. 2004
  7. ncbi request reprint Epidemiology of primary blepharospasm
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences University of Bari, Bari, Italy
    Mov Disord 17:7-12. 2002
  8. ncbi request reprint Primary cervical dystonia and scoliosis: a multicenter case-control study
    G Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, Italy
    Neurology 60:1012-5. 2003
  9. ncbi request reprint Epidemiology of primary dystonia
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Lancet Neurol 3:673-8. 2004
  10. pmc Influence of age on the association between primary hemifacial spasm and arterial hypertension
    G Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    J Neurol Neurosurg Psychiatry 74:979-81. 2003

Detail Information

Publications71

  1. pmc Influence of coffee drinking and cigarette smoking on the risk of primary late onset blepharospasm: evidence from a multicentre case control study
    G Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 78:877-9. 2007
    ..73; p = 0.001) whereas no correlation was found with number of packs of cigarettes per day. Coffee drinking may be inversely associated with the development of primary BSP and this association may partly depend on the amount consumed...
  2. pmc Development and validation of a clinical guideline for diagnosing blepharospasm
    Giovanni Defazio
    Department of Basic Medical Sciences, Neurosciences and Sense organs, Aldo Moro University of Bari, Italy
    Neurology 81:236-40. 2013
    ..To design and validate a clinical diagnostic guideline for aiding physicians in confirming or refuting suspected blepharospasm...
  3. doi request reprint Tremor in primary adult-onset dystonia: prevalence and associated clinical features
    Giovanni Defazio
    Department of Neuroscience and Sensory Organs, Aldo Moro University of Bari, Piazza Giulio Cesare, Bari 2 70124, Italy
    J Neurol Neurosurg Psychiatry 84:404-8. 2013
    ..To investigate the frequency and the main clinical features of tremor in primary adult-onset dystonia (PAOD)...
  4. doi request reprint Phenotypic overlap in familial and sporadic primary adult-onset extracranial dystonia
    Giovanni Defazio
    Department of Neurosciences and Sensory Organs, School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy
    J Neurol 259:2414-8. 2012
    ..The phenotypic overlap we observed between the study groups suggests that familial and sporadic patients with primary adult-onset dystonia other than blepharospasm probably share a common etiological background...
  5. doi request reprint Eye symptoms in relatives of patients with primary adult-onset dystonia
    Giovanni Defazio
    Department of Neurosciences and Sensory Organs, School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy
    Mov Disord 27:305-7. 2012
    ....
  6. ncbi request reprint Primary blepharospasm: diagnosis and management
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Drugs 64:237-44. 2004
    ..As the aetiology of primary blepharospasm is largely unknown, therapeutic approaches are symptomatic, with type A botulinum toxin being the treatment of choice...
  7. ncbi request reprint Epidemiology of primary blepharospasm
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences University of Bari, Bari, Italy
    Mov Disord 17:7-12. 2002
    ..While limited, the body of epidemiological data support the idea that environmental and familial, possibly genetic, factors may both be important in the etiology of BSP...
  8. ncbi request reprint Primary cervical dystonia and scoliosis: a multicenter case-control study
    G Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, Italy
    Neurology 60:1012-5. 2003
    ..To study the distribution of prior scoliosis among patients with primary adult-onset cervical dystonia (CD) and matched control subjects...
  9. ncbi request reprint Epidemiology of primary dystonia
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Lancet Neurol 3:673-8. 2004
    ....
  10. pmc Influence of age on the association between primary hemifacial spasm and arterial hypertension
    G Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    J Neurol Neurosurg Psychiatry 74:979-81. 2003
    ..To investigate the association between primary hemifacial spasm and arterial hypertension...
  11. ncbi request reprint Planning genetic studies on primary adult-onset dystonia: sample size estimates based on examination of first-degree relatives
    Giovanni Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, Bari, Italy
    J Neurol Sci 251:29-34. 2006
    ..These sample size estimates suggest that the S-TDT may be feasible, whereas collection of cases for both TDT and ASP approaches would represent a major collaborative challenge...
  12. ncbi request reprint Environmental risk factors and clinical phenotype in familial and sporadic primary blepharospasm
    G Defazio
    Department of Neurologic and Psychiatric Sciences and School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy
    Neurology 77:631-7. 2011
    ..Although environmental and genetic factors may contribute to the etiology of blepharospasm, their relative contribution in causing familial and sporadic blepharospasm is unknown...
  13. pmc A family study on primary blepharospasm
    G Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 77:252-4. 2006
    ..Previous family studies provided evidence that blepharospasm (BSP) can aggregate in families but did not give accurate and reliable information on the characteristics and degree of familial clustering...
  14. ncbi request reprint Familial blepharospasm is inherited as an autosomal dominant trait and relates to a novel unassigned gene
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 18:207-12. 2003
    ..These findings suggest that primary familial adult-onset BSP is a distinct entity among inherited PTD and is caused by a novel, unmapped gene...
  15. pmc Does sex influence age at onset in cranial-cervical and upper limb dystonia?
    G Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 74:265-7. 2003
    ..A significant inverse association between age at the onset of dystonia and education was observed in both cranial-cervical dystonia and upper limb dystonia series...
  16. doi request reprint The epidemiology of primary dystonia: current evidence and perspectives
    G Defazio
    Department of Neurological and Psychiatric Sciences, School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy
    Eur J Neurol 17:9-14. 2010
    ....
  17. ncbi request reprint Interferon beta-1a downregulates TNFalpha-induced intercellular adhesion molecule 1 expression on brain microvascular endothelial cells through a tyrosine kinase-dependent pathway
    G Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, I 70124, Bari, Italy
    Brain Res 881:227-30. 2000
    ..These findings indicate that a TK- rather than a PKC-dependent mechanism is involved in the modulation of TNFalpha response by IFbeta-1a on BMECs...
  18. ncbi request reprint Prevalence of primary blepharospasm in a community of Puglia region, Southern Italy
    G Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, Italy
    Neurology 56:1579-81. 2001
    ..Prevalence rate increased with age. Apraxia of eyelid opening and BSP coexisted in one third of cases...
  19. doi request reprint Pain as a nonmotor symptom of Parkinson disease: evidence from a case-control study
    Giovanni Defazio
    Department of Neurology and Psychiatry, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    Arch Neurol 65:1191-4. 2008
    ..To determine whether pain is more frequent among people with Parkinson disease (PD) than among age-matched controls...
  20. ncbi request reprint Botulinum toxin A treatment for primary hemifacial spasm: a 10-year multicenter study
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    Arch Neurol 59:418-20. 2002
    ..Botulinum toxin A (BTX) is the currently preferred symptomatic treatment for primary hemifacial spasm (HFS), but its long-term efficacy and safety are not known...
  21. doi request reprint The TOR1A polymorphism rs1182 and the risk of spread in primary blepharospasm
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Policlinico, Piazza Giulio Cesare, Bari 1 70124, Italy
    Mov Disord 24:613-6. 2009
    ..The comparable findings obtained in two independent cohorts support a genetic contribution to BSP spread...
  22. doi request reprint Age at onset and symptom spread in primary adult-onset blepharospasm and cervical dystonia
    Davide Martino
    Department of Neurosciences and Sensory Organs and School of Motor Sciences, Aldo Moro University of Bari, Bari, Italy
    Mov Disord 27:1447-50. 2012
    ..This study explored the relationship between age and spread of dystonia in primary adult-onset focal dystonia...
  23. doi request reprint Midbrain SERT in degenerative parkinsonisms: a 123I-FP-CIT SPECT study
    Francesco Roselli
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 25:1853-9. 2010
    ..SERT-dependent (123)I-FP-CIT uptake may allow a more comprehensive assessment of neurochemical disturbances in degenerative parkinsonisms and may have a value for differential diagnosis...
  24. ncbi request reprint Elevated plasma homocysteine levels in L-dopa-treated Parkinson's disease patients with dyskinesias
    Stefano Zoccolella
    Department of Neurological Sciences, University of Bari, Bari, Italy
    Clin Chem Lab Med 44:863-6. 2006
    ..The aim of the study was to elucidate a possible role of L-dopa-related hyperhomocysteinemia in the development of dyskinesias...
  25. ncbi request reprint Relationship between eye symptoms and blepharospasm: a multicenter case-control study
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 20:1564-70. 2005
    ..The differential risk of developing BSP, based on age at onset of ocular symptoms, suggests that age and eye diseases may interact in giving rise to BSP...
  26. pmc Head trauma in primary cranial dystonias: a multicentre case-control study
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare, 11 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 78:260-3. 2007
    ..The relationship between prior trauma and primary adult-onset dystonia is not well understood. Previous uncontrolled observations and exploratory case-control studies have yielded contradictory results...
  27. ncbi request reprint Differential regulation of membrane bound and soluble ICAM 1 in human endothelium and blood mononuclear cells: effects of interferon beta-1a
    Maurizio Giorelli
    Department of Neurologic and Psychiatric Sciences, University of Bari, Bari, Italy
    Cell Commun Adhes 9:259-72. 2002
    ..We show that IFNbeta-1a is strong regulator of the ICAM 1 RNA splicing machinery. Effect of IFNbeta-1a over expression of the ICAM 1 isoforms might have a relevant immunomoregulatory role in Multiple Sclerosis...
  28. ncbi request reprint Do primary adult-onset focal dystonias share aetiological factors?
    Giovanni Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, Bari, Italy
    Brain 130:1183-93. 2007
    ....
  29. ncbi request reprint Hyperhomocysteinemia in movement disorders: Current evidence and hypotheses
    Stefano Zoccolella
    Department of Neurological Sciences, University of Bari, Italy
    Curr Vasc Pharmacol 4:237-43. 2006
    ....
  30. ncbi request reprint Are nongenetic triggers for dystonia type-specific? A study exploring scoliosis in blepharospasm
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 22:576-8. 2007
    ..The frequency of scoliosis did not differ between blepharospasm patients and controls. This finding supports the hypothesis that environmental risk factors may be specific for a single form of adult-onset dystonia...
  31. ncbi request reprint Validity of family history data on primary adult-onset dystonia
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, 1 70124 Bari, Italy
    Arch Neurol 61:1569-73. 2004
    ..To our knowledge, no study has assessed the validity of family history data provided by probands with adult-onset dystonia...
  32. doi request reprint The phenomenology of the geste antagoniste in primary blepharospasm and cervical dystonia
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Mov Disord 25:407-12. 2010
    ..01). GA features shared by BSP and CD predominate over differences, suggesting common mechanisms underlying this phenomenon in the two forms of primary adult-onset dystonia...
  33. ncbi request reprint Sensitivity and specificity of a self-administered questionnaire for familial screening of adult-onset dystonia
    Maria Stella Aniello
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Mov Disord 21:571-5. 2006
    ..This questionnaire may be an important screening resource for familial aggregation studies to be used in the context of a complex case-finding procedure...
  34. doi request reprint Rate of MMSE score change in Alzheimer's disease: influence of education and vascular risk factors
    Francesco Roselli
    Department of Neurological and Psychiatric Sciences, University of Bari, I 70124 Bari, Italy
    Clin Neurol Neurosurg 111:327-30. 2009
    ..To test whether higher education accelerates Alzheimer's Disease (AD) progression rate through an effect on the cognitive reserve capabilities of an individual...
  35. ncbi request reprint Menopause and menarche in patients with primary blepharospasm: an exploratory case-control study
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Eur Neurol 47:161-4. 2002
    ....
  36. ncbi request reprint Blepharospasm in bardet-biedl syndrome: a case report
    Francesco Roselli
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Eur Neurol 48:230-2. 2002
  37. pmc Is increased blinking a form of blepharospasm?
    Antonella Conte
    Department of Neurology and Psychiatry, Sapienza University of Rome, Italy
    Neurology 80:2236-41. 2013
    ..The aim of this study was to investigate whether increased blink rate (BR) is part of the clinical spectrum of primary blepharospasm (BSP)...
  38. doi request reprint Severity of neuropsychiatric symptoms and dopamine transporter levels in dementia with Lewy bodies: a 123I-FP-CIT SPECT study
    Francesco Roselli
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 24:2097-103. 2009
    ..The seresults provide intriguing evidence on the involvement of the mesocortical dopaminergic pathways in neuropsychiatric symptoms in DLB...
  39. doi request reprint The epidemiology of pain in Parkinson's disease
    Giovanni Defazio
    Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Aldo Moro, University of Bari, Policlinico, Piazza Giulio Cesare 1, 70124, Bari, Italy
    J Neural Transm 120:583-6. 2013
    ..Some evidence raises the possibility of common mechanisms shared by pain patients, regardless of the clinical heterogeneity of pain and its variable relationship with motor signs...
  40. doi request reprint Cortical gray matter changes in primary blepharospasm: a voxel-based morphometry study
    Davide Martino
    Neurological Section, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 26:1907-12. 2011
    ..Gray matter changes in the primary sensory cortex may represent a common trait of primary dystonias, including blepharospasm...
  41. ncbi request reprint Interferon beta-1a counteracts effects of activation on the expression of G-protein-coupled receptor kinases 2 and 3, beta-arrestin-1, and regulators of G-protein signalling 2 and 16 in human mononuclear leukocytes
    Maurizio Giorelli
    Department of Neurologic and Psychiatric Sciences, University of Bari, I 70124 Bari, Italy
    Cell Signal 14:673-8. 2002
    ..Furthermore, IFN beta-1a quenches the effects of PHA on the isoproterenol-induced accumulation of cyclic AMP (cAMP). We suggest that regulation of GPCRs responsiveness may be a relevant property of IFN beta-1a in MS...
  42. doi request reprint Speech-induced blepharospasm
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, 70124, Bari, Italy
    Neurol Sci 31:71-3. 2010
    ....
  43. doi request reprint Brain F-18 Fluorocholine PET/CT for the assessment of optic pathway glioma in neurofibromatosis-1
    Francesco Roselli
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Clin Nucl Med 35:838-9. 2010
    ..Molecular imaging of optic pathway gliomas may be a valuable tool in the selection of therapeutic options...
  44. doi request reprint Impaired cognitive functions in adult-onset primary cranial cervical dystonia
    Raffaella Romano
    Department of Basic Medical Sciences, Neuroscience and Sense Organs, Aldo Moro University of Bari, Italy Electronic address
    Parkinsonism Relat Disord 20:162-5. 2014
    ..Nevertheless, several studies provided evidence that sensory and psychiatric disturbances may contribute to the clinical spectrum of of dystonia, whereas evidence supporting cognitive impairment is still limited...
  45. ncbi request reprint Plasma homocysteine levels in L-dopa-treated Parkinson's disease patients with cognitive dysfunctions
    Stefano Zoccolella
    Department of Neurological Sciences, University of Bari, Bari, Italy
    Clin Chem Lab Med 43:1107-10. 2005
    ..However, prospective studies on large cohorts of patients should be performed to clarify such an association...
  46. ncbi request reprint Bilateral striatal necrosis, dystonia and multiple mitochondrial DNA deletions: case study and effect of deep brain stimulation
    Maria Stella Aniello
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 23:114-8. 2008
    ..Globus pallidus interna deep brain stimulation produced sustained benefit, with predominant improvements in disability...
  47. ncbi request reprint Brain-derived neurotrophic factor and risk for primary adult-onset cranial-cervical dystonia
    D Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Eur J Neurol 16:949-52. 2009
    ..In this study we aimed at exploring the effect of this SNP upon the risk of developing common forms of primary adult-onset dystonia...
  48. ncbi request reprint Frequency of familial aggregation in primary adult-onset cranial cervical dystonia
    G Defazio
    Department of Neurological and Psychiatric Sciences, Section of Neurology, University of Bari, Bari, Italy
    Neurol Sci 24:168-9. 2003
    ..These observations raise the possibility that probable dystonia represents formes frustes/mild phenotypes of dystonia rather than another movement disorder...
  49. ncbi request reprint Proton MR spectroscopy in idiopathic spasmodic torticollis
    F Federico
    Department of Neurology and Psychiatry, Bari, Italy
    Neuroradiology 43:532-6. 2001
    ..0304 and 0.0431, respectively). These results indicate a reduction in NAA, and suggest striatal involvement in the pathogenesis IST...
  50. ncbi request reprint Interferon beta-1a prevents the effects of lipopolysaccharide on embryonic brain microvessels
    B Nico
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Policlinico, Piazza G Cesare, 11, I 70124, Bari, Italy
    Brain Res Dev Brain Res 119:231-42. 2000
    ..These results indicate that the changes induced by LPS in the endothelial cells are prevented by IFNbeta-1a...
  51. ncbi request reprint Changes of serum sICAM-1 and MMP-9 induced by rIFNbeta-1b treatment in relapsing-remitting MS
    M Trojano
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Neurology 53:1402-8. 1999
    ....
  52. ncbi request reprint Inhibition of protein kinase C counteracts TNFalpha-induced intercellular adhesion molecule 1 expression and fluid phase endocytosis on brain microvascular endothelial cells
    G Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, I 70124, Bari, Italy
    Brain Res 863:245-8. 2000
    ..5-10 nM) did not. These findings indicate that a PKC-dependent mechanism may affect TNFalpha signalling on different barrier properties of BMECs...
  53. ncbi request reprint Psychiatric disorders in patients with essential tremor
    Giovanni Fabbrini
    Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy
    Parkinsonism Relat Disord 18:971-3. 2012
    ..Previous studies have reported that a consistent proportion of patients with Essential Tremor may have psychiatric disorders but it is unclear whether these disorders are increased in frequency as compared to healthy subjects...
  54. ncbi request reprint Frequency of apraxia of eyelid opening in the general population and in patients with extrapyramidal disorders
    P Lamberti
    Department of Neurologic and Psychiatric Sciences, Section of Neurology, University of Bari, I 70124 Bari, Italy
    Neurol Sci 23:S81-2. 2002
    ..AEO developing in the setting of a parkinsonian syndrome may be either disease- or drug-related...
  55. ncbi request reprint In vitro modulation of adhesion molecules, adhesion phenomena, and fluid phase endocytosis on human umbilical vein endothelial cells and brain-derived microvascular endothelium by IFN-beta 1a
    G Defazio
    Istituto di Clinica Neurologica, , Policlinico, Bari, Italy
    J Interferon Cytokine Res 21:267-72. 2001
    ..In our study, 200 U/ml IFN-beta1a induced a reduction in adhesion of PBMC to HUVEC. The information reported herein may contribute to further elucidating some of the mechanisms of action of IFN-beta on vascular endothelium...
  56. doi request reprint Facial bradykinesia
    Matteo Bologna
    Neuromed Institute IRCCS, Pozzilli Is, Italy
    J Neurol Neurosurg Psychiatry 84:681-5. 2013
    ..In PD, facial bradykinesia is primarily mediated by basal ganglia dysfunction whereas in PSP, facial bradykinesia is a consequence of a widespread degeneration involving the basal ganglia, cortical and brainstem structures...
  57. doi request reprint The PANDAS subgroup of tic disorders and childhood-onset obsessive-compulsive disorder
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    J Psychosom Res 67:547-57. 2009
    ..Given the relevance of this topic for general pediatric health, additional research efforts to solve all the pending issues and the hottest points of debate are warranted...
  58. ncbi request reprint IFN-beta1a modulates the expression of CTLA-4 and CD28 splice variants in human mononuclear cells: induction of soluble isoforms
    M Giorelli
    Department of Neurologic and Psychiatric Sciences, University of Bari, Bari, Italy
    J Interferon Cytokine Res 21:809-12. 2001
    ..Because soluble CD28 and CTLA-4 molecules might affect T cell activation, our findings suggest an additional means whereby IFN-beta therapy might exert its immunomodulatory effects in multiple sclerosis (MS)...
  59. doi request reprint Lower limb involvement in adult-onset primary dystonia: frequency and clinical features
    D Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Eur J Neurol 17:242-6. 2010
    ..Despite the growing number of reports describing adult-onset primary lower limb dystonia (LLD) this entity has never been systematically evaluated in the general population of patients with primary adult-onset dystonia...
  60. ncbi request reprint Anti-basal ganglia antibodies and Tourette's syndrome: a voxel-based morphometry and diffusion tensor imaging study in an adult population
    D Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 79:820-2. 2008
    ..These results suggest that ABGA synthesis is not related to structural changes in grey and white matter (detectable with these methods) within frontostriatal circuits...
  61. ncbi request reprint Fatigue in Parkinson's disease
    A Zenzola
    Department of Neurological Sciences, University of Bari, Bari, Italy
    Neurol Sci 24:225-6. 2003
    ..Our analysis showed the usefulness of the MFI in discriminating between different dimensions of fatigue for a better therapeutic approach...
  62. ncbi request reprint Assessing the role of DRD5 and DYT1 in two different case-control series with primary blepharospasm
    Jordi Clarimon
    Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 22:162-6. 2007
    ..These data suggest that further examination is warranted of the role genetic variability at this locus plays in the risk for primary dystonia...
  63. ncbi request reprint Novel Italian family supports clinical and genetic heterogeneity of primary adult-onset torsion dystonia
    Francesco Brancati
    Istituto C S S Mendel, Rome, Italy
    Mov Disord 17:392-7. 2002
    ..These findings support genetic heterogeneity of PTD and indicate that a novel unassigned gene is responsible for focal dystonia in this family...
  64. ncbi request reprint Mirror movements in patients with Parkinson's disease
    Donatella Ottaviani
    Department of Neurological Sciences and Neuromed Institute IRCCS, La Sapienza University of Rome, Rome, Italy
    Mov Disord 23:253-8. 2008
    ..16, P < 0.01). The low frequency of MM in PD probably relates to the complex interactions between the pathophysiological mechanisms leading to parkinsonian signs and the mechanisms responsible for movement lateralization...
  65. doi request reprint Cortical excitability is abnormal in patients with the "fixed dystonia" syndrome
    Laura Avanzino
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 23:646-52. 2008
    ..SAI and LAI did not significantly differ between the three groups. The abnormal cortical excitability observed in FD might represent an underlying trait predisposing to different clinical forms of dystonia...
  66. ncbi request reprint Abnormal processing of the nociceptive input in Parkinson's disease: a study with CO2 laser evoked potentials
    Michele Tinazzi
    Dipartimento di Scienze Neurologiche e della Visione, Sezione di Neurologia Riabilitativa, Universita di Verona, Italy
    Pain 136:117-24. 2008
    ..These results suggest an abnormal nociceptive input processing in pain-free PD patients which appears to be independent of clinical expression of parkinsonian motor signs and is not affected by dopaminergic stimulation...
  67. ncbi request reprint Antineuronal antibody status and phenotype analysis in Tourette's syndrome
    Davide Martino
    Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 22:1424-9. 2007
    ..14; P = 0.002; 95% confidence interval 0.04-0.49). ANeA status does not differentiate a specific phenotype of GTS...
  68. ncbi request reprint Defective temporal processing of sensory stimuli in DYT1 mutation carriers: a new endophenotype of dystonia?
    Mirta Fiorio
    Department of Neurological and Vision Sciences, Section of Rehabilitative Neurology, University of Verona, Verona, Italy
    Brain 130:134-42. 2007
    ....
  69. ncbi request reprint A comparative study of primary and secondary hemifacial spasm
    Carlo Colosimo
    Department of Neurosciences and Neuromed Institute, University of Rome La Sapienza, Rome, Italy
    Arch Neurol 63:441-4. 2006
    ..Hemifacial spasm (HFS) is a common movement disorder...
  70. pmc Update on blepharospasm: report from the BEBRF International Workshop
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, 10 Center Drive MSC 1428, Bethesda, MD 20892 1428, USA
    Neurology 71:1275-82. 2008
    ..Physiologic studies indicate increased plasticity and trigeminal sensitization. While botulinum neurotoxin injections are the mainstay of therapy, other therapies are on the horizon...