S De Flora

Summary

Affiliation: University of Genoa
Country: Italy

Publications

  1. doi request reprint Exposure of mice to cigarette smoke and/or light causes DNA alterations in heart and aorta
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Mutat Res 644:38-42. 2008
  2. ncbi request reprint Overview of mechanisms of cancer chemopreventive agents
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 591:8-15. 2005
  3. doi request reprint Genotoxicity and carcinogenicity of the light emitted by artificial illumination systems
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, 16132, Genoa, Italy
    Arch Toxicol 87:403-5. 2013
  4. doi request reprint Smoke-induced microRNA and related proteome alterations. Modulation by chemopreventive agents
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Int J Cancer 131:2763-73. 2012
  5. ncbi request reprint Transplacental antioxidants inhibit lung tumors in mice exposed to cigarette smoke after birth: a novel preventative strategy?
    R Balansky
    National Center of Oncology, Sofia 1756, Bulgaria
    Curr Cancer Drug Targets 12:164-9. 2012
  6. ncbi request reprint Mechanisms of inhibitors of mutagenesis and carcinogenesis
    S De Flora
    Institute of Hygiene and Preventive Medicine, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 402:151-8. 1998
  7. ncbi request reprint Induction and modulation of lung tumors: genomic and transcriptional alterations in cigarette smoke-exposed mice
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Exp Lung Res 31:19-35. 2005
  8. ncbi request reprint [Mechanistic issues and prevention strategies targeting occupational carcinogenesis]
    Silvio De Flora
    Dipartimento di Scienze della Salute, Universita degli Studi di Genova, Italy
    G Ital Med Lav Ergon 33:294-9. 2011
  9. doi request reprint Upregulation of clusterin in prostate and DNA damage in spermatozoa from bisphenol A-treated rats and formation of DNA adducts in cultured human prostatic cells
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Toxicol Sci 122:45-51. 2011
  10. pmc The prevention of infection-associated cancers
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 32:787-95. 2011

Collaborators

Detail Information

Publications77

  1. doi request reprint Exposure of mice to cigarette smoke and/or light causes DNA alterations in heart and aorta
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Mutat Res 644:38-42. 2008
    ..Although the pathogenetic meaning is uncertain, DNA damage in heart and aorta may tentatively be related to cardiomyopathies and to the atherogenesis process, respectively...
  2. ncbi request reprint Overview of mechanisms of cancer chemopreventive agents
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 591:8-15. 2005
    ..It is also possible to affect cell-adhesion molecules, to activate antimetastasis genes, and to inhibit proteases involved in basement membrane degradation...
  3. doi request reprint Genotoxicity and carcinogenicity of the light emitted by artificial illumination systems
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, 16132, Genoa, Italy
    Arch Toxicol 87:403-5. 2013
    ..Since IARC has classified UV radiation in Group 1, any source of UV light poses a carcinogenic hazard to humans. Suitable regulations would be needed in order to control the safety of the light emitted by artificial light sources...
  4. doi request reprint Smoke-induced microRNA and related proteome alterations. Modulation by chemopreventive agents
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Int J Cancer 131:2763-73. 2012
    ..A variety of cancer chemopreventive agents tested in our laboratory modulated both baseline and CS-related miRNA and proteome alterations, thus contributing to evaluate both safety and efficacy of dietary and pharmacological agents...
  5. ncbi request reprint Transplacental antioxidants inhibit lung tumors in mice exposed to cigarette smoke after birth: a novel preventative strategy?
    R Balansky
    National Center of Oncology, Sofia 1756, Bulgaria
    Curr Cancer Drug Targets 12:164-9. 2012
    ..0% to 14.3% by prenatal NAC. These data mechanistically support a "transplacental chemoprevention" strategy, aimed at protecting the newborn from oxidative stress and the adult from CS-related diseases appearing later in life...
  6. ncbi request reprint Mechanisms of inhibitors of mutagenesis and carcinogenesis
    S De Flora
    Institute of Hygiene and Preventive Medicine, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 402:151-8. 1998
    ..Similarly, a number of protective agents are shown to work through multiple and often interconnected mechanisms...
  7. ncbi request reprint Induction and modulation of lung tumors: genomic and transcriptional alterations in cigarette smoke-exposed mice
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Exp Lung Res 31:19-35. 2005
    ..Smoke-induced genomic and transcriptional alterations were suitable for evaluating their modulation by chemopreventive agent, as shown in studies using the thiol N-acetylcysteine and the nonsteroidal anti-inflammatory drug sulindac...
  8. ncbi request reprint [Mechanistic issues and prevention strategies targeting occupational carcinogenesis]
    Silvio De Flora
    Dipartimento di Scienze della Salute, Universita degli Studi di Genova, Italy
    G Ital Med Lav Ergon 33:294-9. 2011
    ..A controversial issue is the occurrence of threshold doses for carcinogens in the workplace and the environment...
  9. doi request reprint Upregulation of clusterin in prostate and DNA damage in spermatozoa from bisphenol A-treated rats and formation of DNA adducts in cultured human prostatic cells
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Toxicol Sci 122:45-51. 2011
    ..On the whole, these experimental findings support mechanistically the hypothesis that BPA may play a role in prostate carcinogenesis and may, potentially, affect the quality of sperm...
  10. pmc The prevention of infection-associated cancers
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 32:787-95. 2011
    ..pylori infections...
  11. ncbi request reprint High susceptibility of neonatal mice to molecular, biochemical and cytogenetic alterations induced by environmental cigarette smoke and light
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 659:137-46. 2008
    ..The findings of these studies provide a mechanistic clue to the general concept that the neonatal period and early stages of life are critical in affecting susceptibility to carcinogens...
  12. ncbi request reprint Lack of genotoxic effects in hematopoietic and gastrointestinal cells of mice receiving chromium(VI) with the drinking water
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 659:60-7. 2008
    ..These results are discussed in the light of literature data, also including a recent 2-year carcinogenicity study performed by the National Toxicology Program...
  13. ncbi request reprint Molecular alterations and lung tumors in p53 mutant mice exposed to cigarette smoke
    Silvio De Flora
    Department of Health Sciences, University of Genoa, I 16132 Genoa, Italy
    Cancer Res 63:793-800. 2003
    ..These findings provide evidence that p53 mutations play a role in smoke-related carcinogenesis not only in humans but also in A/J mice...
  14. ncbi request reprint Modulation of cigarette smoke-related end-points in mutagenesis and carcinogenesis
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 523:237-52. 2003
    ..We are trying to develop a pharmacogenomic approach, e.g. based on genetic metabolic polymorphisms, aimed at predicting not only the risk of developing cancer but also the individual responsiveness to chemopreventive agents...
  15. ncbi request reprint Induction by 7,12-dimethylbenz(a)anthracene of molecular and biochemical alterations in transformed human mammary epithelial stem cells, and protection by N-acetylcysteine
    Silvio De Flora
    Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genoa, I 16132 Genoa, Italy
    Int J Oncol 29:521-9. 2006
    ..Thus, the immortal cell line derived from the normal human adult breast stem cell without further tumorigenic progression is the most susceptible both to DMBA-related alterations and to the protective effects of NAC...
  16. ncbi request reprint Multiple points of intervention in the prevention of cancer and other mutation-related diseases
    S De Flora
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Mutat Res 480:9-22. 2001
    ....
  17. doi request reprint Modulation of genomic and postgenomic alterations in noncancer diseases and critical periods of life
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 667:15-26. 2009
    ..The discovery that chemopreventive agents are also able to attenuate nucleotide damage in stem-derived cells warrants further studies in view of possible clinical applications...
  18. ncbi request reprint Mutagenesis and cardiovascular diseases Molecular mechanisms, risk factors, and protective factors
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 621:5-17. 2007
    ..Prevention of both cancer and atherosclerosis is based on avoidance of exposure to risk factors and on fortification of the host defense mechanisms by means of dietary principles and chemopreventive drugs...
  19. ncbi request reprint DNA adducts and chronic degenerative disease. Pathogenetic relevance and implications in preventive medicine
    S De Flora
    Institute of Hygiene and Preventive Medicine, University of Genoa, Italy
    Mutat Res 366:197-238. 1996
    ..The efficacy of chemopreventive agents can be assessed by evaluating inhibition of nuclear DNA or mitochondrial DNA adduct formation in vitro, in animal models, and in phase II clinical trials in high-risk individuals...
  20. ncbi request reprint Estimates of the chromium(VI) reducing capacity in human body compartments as a mechanism for attenuating its potential toxicity and carcinogenicity
    S De Flora
    Institute of Hygiene and Preventive Medicine, University of Genoa, Italy
    Carcinogenesis 18:531-7. 1997
    ..These hurdles could be only overwhelmed under conditions of massive exposure by inhalation, as it occurred in certain work environments prior to the implementation of suitable industrial hygiene measures...
  21. ncbi request reprint Modulation of the potency of promutagens and direct acting mutagens in bacteria by inhibitors of the multidrug resistance mechanism
    S De Flora
    Institute of Hygiene and Preventive Medicine, University of Genoa, Italy
    Mutagenesis 12:431-5. 1997
    ....
  22. ncbi request reprint The epidemiological revolution of the 20th century
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    FASEB J 19:892-7. 2005
    ....
  23. ncbi request reprint Modulation of genotoxic and related effects by carotenoids and vitamin A in experimental models: mechanistic issues
    S De Flora
    Department of Health Sciences, University of Genoa, Italy
    Mutagenesis 14:153-72. 1999
    ....
  24. ncbi request reprint Threshold mechanisms and site specificity in chromium(VI) carcinogenesis
    S De Flora
    Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 21:533-41. 2000
    ..All experimental and epidemiological data, and the underlying mechanisms, point to the occurrence of thresholds in chromium(VI) carcinogenesis...
  25. ncbi request reprint Oral chromium(VI) does not affect the frequency of micronuclei in hematopoietic cells of adult mice and of transplacentally exposed fetuses
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 610:38-47. 2006
    ..These conclusions are consistent with the poor toxicity and lack of carcinogenicity of oral chromium(VI), and are mechanistically explained by the high efficiency of chromium(VI) detoxification processes in the gastrointestinal tract...
  26. ncbi request reprint Molecular and cytogenetical alterations induced by environmental cigarette smoke in mice heterozygous for Fhit
    Silvio De Flora
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Cancer Res 67:1001-6. 2007
    ....
  27. ncbi request reprint Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points
    S De Flora
    Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 22:999-1013. 2001
    ..On the whole, there is overwhelming evidence that NAC has the ability to modulate a variety of DNA damage- and cancer-related end-points...
  28. ncbi request reprint Modulation of biomarkers by chemopreventive agents in smoke-exposed rats
    A Izzotti
    Department of Health Sciences, University of Genoa, Italy
    Cancer Res 61:2472-9. 2001
    ....
  29. ncbi request reprint Oltipraz chemoprevention trial in Qidong, People's Republic of China: results of urine genotoxicity assays as related to smoking habits
    A Camoirano
    Department of Health Sciences, University of Genoa, Via A. Pastore 1, I-16132 Genoa, Italy
    Cancer Epidemiol Biomarkers Prev 10:775-83. 2001
    ....
  30. ncbi request reprint Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the respiratory tract of rats
    R M Balansky
    Department of Health Sciences, University of Genoa, Via A. Pastore 1, I-16132 Genoa, Italy
    Carcinogenesis 22:375-80. 2001
    ..Thus, it is important to discriminate between whether the opposite modulation of apoptosis is per se a protective mechanism or the beneficial outcome of other mechanisms inhibiting genotoxicity...
  31. ncbi request reprint Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents
    A Izzotti
    Department of Health Sciences, University of Genoa, Via Pastore 1, I-16132, Genoa, Italy
    Mutat Res 494:97-106. 2001
    ....
  32. ncbi request reprint Systemic genotoxic effects produced by light, and synergism with cigarette smoke in the respiratory tract of hairless mice
    Roumen M Balansky
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 24:1525-32. 2003
    ..This damage may mechanistically be involved in light-related hematopoietic malignancies. In addition, the light displayed an insofar unsuspected synergism with smoke in the induction of DNA damage in the respiratory tract...
  33. ncbi request reprint Pilot studies evaluating the lung tumor yield in cigarette smoke-exposed mice
    R M Balansky
    Department of Health Sciences, Section of Hygiene and Preventive Medicine, University of Genoa, Genoa, Italy
    Int J Oncol 18:607-15. 2001
    ..The whole-body exposure of C57BL/6 mice to ECS for 6 months failed to induce any lung tumor but caused alopecia, gray hair, and hair bulb cell apoptosis, which were prevented by the oral administration of N-acetylcysteine...
  34. ncbi request reprint Genomic and transcriptional alterations in mouse fetus liver after transplacental exposure to cigarette smoke
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132, Italy
    FASEB J 17:1127-9. 2003
    ..Moreover, hypoxia-related genes and several oncogenes and receptors involved in proliferation and differentiation of leukocytes were induced in the fetal liver, which also bears hematopoietic functions...
  35. ncbi request reprint Diet-derived phytochemicals: from cancer chemoprevention to cardio-oncological prevention
    N Ferrari
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Curr Drug Targets 12:1909-24. 2011
    ....
  36. ncbi request reprint Increased DNA alterations in atherosclerotic lesions of individuals lacking the GSTM1 genotype
    A Izzotti
    Department of Health Sciences, University of Genoa, Italy
    FASEB J 15:752-7. 2001
    ....
  37. doi request reprint Modulation by phenethyl isothiocyanate and budesonide of molecular and histopathologic alterations induced by environmental cigarette smoke in mice
    Francesco D'Agostini
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Cancer Prev Res (Phila) 2:546-56. 2009
    ..Thus, although not as efficiently as the bioassay in mainstream cigarette smoke-exposed mice, the model in neonatal mice is suitable to evaluate both ECS carcinogenicity and its modulation by chemopreventive agents...
  38. ncbi request reprint Gene expression in the lung of p53 mutant mice exposed to cigarette smoke
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Cancer Res 64:8566-72. 2004
    ..Taken together, these findings may explain the increased susceptibility of p53 mutant mice to smoke-related alterations of intermediate biomarkers and lung carcinogenesis...
  39. ncbi request reprint Inhibition of angiogenesis-driven Kaposi's sarcoma tumor growth in nude mice by oral N-acetylcysteine
    A Albini
    National Institute for Cancer Research IST, c o Advanced Biotechnology Center, Largo R Benzi 10, I 16132 Genoa, Italy
    Cancer Res 61:8171-8. 2001
    ....
  40. ncbi request reprint Early loss of Fhit in the respiratory tract of rodents exposed to environmental cigarette smoke
    Francesco D'Agostini
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Cancer Res 66:3936-41. 2006
    ..In conclusion, there is unequivocal evidence that Fhit is an early, critical target in smoke-related lung carcinogenesis in rodents, and that certain chemopreventive agents can attenuate the occurrence of this gene alteration...
  41. ncbi request reprint Potent carcinogenicity of cigarette smoke in mice exposed early in life
    Roumen Balansky
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 28:2236-43. 2007
    ..This animal model will be useful to explore the mechanisms involved in CS-induced carcinogenesis and to investigate the protective effects of dietary agents and chemopreventive drugs...
  42. pmc Relationships of microRNA expression in mouse lung with age and exposure to cigarette smoke and light
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    FASEB J 23:3243-50. 2009
    ..Both gender and age affected smoke-related microRNA dysregulation in mice. The data presented provide supporting evidence that microRNAs play a fundamental role in both physiological and pathological changes occurring in mouse lung...
  43. doi request reprint Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Italy
    Cancer Prev Res (Phila) 3:62-72. 2010
    ..Therefore, microRNA analysis may provide a new tool for predicting at early carcinogenesis stages both the potential safety and efficacy of cancer chemopreventive agents...
  44. ncbi request reprint Alterations of gene expression in skin and lung of mice exposed to light and cigarette smoke
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    FASEB J 18:1559-61. 2004
    ..These results provide a mechanistic insight explaining the systemic alterations induced by both light and smoke in mouse skin and lungs...
  45. ncbi request reprint Birth-related genomic and transcriptional changes in mouse lung. Modulation by transplacental N-acetylcysteine
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, Genoa I 16132, Italy
    Mutat Res 544:441-9. 2003
    ..It therefore appears that administration of NAC during pregnancy is beneficial not only to counteract the adverse effects of toxic agents, as supported by previous studies, but also to attenuate birth-related DNA alterations...
  46. ncbi request reprint Proteomic analysis as related to transcriptome data in the lung of chromium(VI)-treated rats
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, I 16132 Genoa, Italy
    Int J Oncol 24:1513-22. 2004
    ..However, this parallelism is re-established when the cell undergoes genotoxic damage...
  47. pmc Preneoplastic and neoplastic lesions in the lung, liver and urinary tract of mice exposed to environmental cigarette smoke and UV light since birth
    Francesco D'Agostini
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Int J Cancer 123:2497-502. 2008
    ..The results obtained with ECS cannot be directly compared to those previously obtained with MCS, since the latter involved shorter daily exposures to more massive CS doses...
  48. ncbi request reprint Selective induction of gene expression in rat lung by hexavalent chromium
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Italy
    Mol Carcinog 35:75-84. 2002
    ....
  49. pmc Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: chemoprevention by budesonide and N-acetylcysteine
    Roumen Balansky
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 103:7823-8. 2006
    ..In conclusion, heterozygosity for FHIT affects susceptibility of mice to spontaneous alopecia areata and B[a]P-induced preneoplastic lesions of the uterus and does not alter responsiveness to budesonide and NAC...
  50. ncbi request reprint Induction of apoptosis in the lung but not in the liver of rats receiving intra-tracheal instillations of chromium(VI)
    Francesco D'Agostini
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 23:587-93. 2002
    ..Therefore, apoptosis is likely to provide a protective mechanism at a post-genotoxic stage of Cr(VI) carcinogenesis...
  51. ncbi request reprint Modulation of apoptosis by cancer chemopreventive agents
    Francesco D'Agostini
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 591:173-86. 2005
    ..We suggest that stimulation of apoptosis by so many chemopreventive agents, as reported in the literature, may often reflect the occurrence of toxic effects at high doses...
  52. pmc Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 31:894-901. 2010
    ..PEITC and BUD protected the lung from ECS-induced alterations of miRNA expression but exhibited some adverse effects in liver...
  53. ncbi request reprint Survival of atherosclerotic patients as related to oxidative stress and gene polymorphisms
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 621:119-28. 2007
    ..Survival was significantly affected not only by traditional risk factors for atherosclerosis but also by molecular end-points and adverse gene polymorphisms, and by their combinations...
  54. ncbi request reprint Chemoprevention of genome, transcriptome, and proteome alterations induced by cigarette smoke in rat lung
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Eur J Cancer 41:1864-74. 2005
    ....
  55. ncbi request reprint Modulation of multigene expression and proteome profiles by chemopreventive agents
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Mutat Res 591:212-23. 2005
    ..OPZ was poorly effective in lung and considerably altered the basal gene expression in liver. NAC had a medium efficacy and was the safest agent, as also supported by the analysis of 518 proteins in rat lung...
  56. ncbi request reprint Chemoprevention of smoke-induced alopecia in mice by oral administration of L-cystine and vitamin B6
    Francesco D'Agostini
    Section of Hygiene and Preventive Medicine, Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    J Dermatol Sci 46:189-98. 2007
    ..This effect was prevented by the oral administration of N-acetylcysteine (NAC), an analogue and precursor of L-cysteine and reduced glutathione...
  57. ncbi request reprint Effects of aminothiols in 2-acetylaminofluorene-treated rats. II. Glutathione cycle and liver cytosolic activities
    C F Cesarone
    Institute of General Physiology, University of Genoa, Italy
    In Vivo 1:93-9. 1987
    ..Hepatocellular glutathione was enhanced during the last cycle of treatment with 2-acetylaminofluorene, and was further increased by co-administration of exogenous glutathione...
  58. ncbi request reprint Detection of p53 and histopathological classification of skin tumours induced by halogen lamps in hairless mice
    F D'Agostini
    Institute of Hygiene and Preventive Medicine, University of Genoa, Italy
    Cancer Lett 86:167-75. 1994
    ..Thus, p53 mutation appears to be a late event in the development of halogen-induced skin tumours in hairless mice, requiring a severe degree of malignancy and an advanced stage of the neoplastic mass growth...
  59. ncbi request reprint Upregulation of stem cell antigen-1 in the lung of neonatal mice exposed to environmental cigarette smoke
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, I 16132 Genoa, Italy
    Oncol Rep 22:469-74. 2009
    ..These findings may contribute to explain the high vulnerability of mouse lung early in life...
  60. ncbi request reprint Pharmacological modulation of genome and proteome alterations in mice treated with the endocrine disruptor bisphenol A
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Curr Cancer Drug Targets 10:147-54. 2010
    ..Therefore, the in vivo use of proteome analysis proves to be a sensitive tool for the early prediction not only of protective effects but also of adverse effects of chemopreventive agents...
  61. pmc Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    FASEB J 23:806-12. 2009
    ..Five ECS-down-regulated microRNAs are known to be affected by single nucleotide polymorphisms. Thus, changes in microRNA expression are an early event following exposure to cigarette smoke...
  62. ncbi request reprint Budesonide and phenethyl isothiocyanate attenuate DNA damage in bronchoalveolar lavage cells of mice exposed to environmental cigarette smoke
    Rosanna T Micale
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Curr Cancer Drug Targets 8:703-8. 2008
    ....
  63. ncbi request reprint Interplay between Helicobacter pylori and host gene polymorphisms in inducing oxidative DNA damage in the gastric mucosa
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132, Genoa, Italy
    Carcinogenesis 28:892-8. 2007
    ..The interplay between bacterial and host gene polymorphisms may explain why gastric cancer only occurs in a small fraction of H.pylori-infected individuals...
  64. ncbi request reprint Modulation of light-induced skin tumors by N-acetylcysteine and/or ascorbic acid in hairless mice
    Francesco D'Agostini
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 26:657-64. 2005
    ..Therefore, in agreement with our previous in vitro findings, oral NAC is able to attenuate the detrimental effects of AsA...
  65. ncbi request reprint Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Am J Med 114:638-46. 2003
    ..Some investigators have hypothesized that oxidative damage may be involved. We evaluated oxidative deoxyribonucleic acid (DNA) damage, in terms of 8-hydroxy-2'-deoxyguanosine (8-OH-dG), in the eyes of glaucoma patients...
  66. doi request reprint Formation of adducts by bisphenol A, an endocrine disruptor, in DNA in vitro and in liver and mammary tissue of mice
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Genoa, Italy
    Mutat Res 679:28-32. 2009
    ....
  67. ncbi request reprint [Open angle glaucoma: epidemiology, pathogenesis and prevention]
    Alberto Izzotti
    Dipartimento di Scienze della Salute, Universita, Genova
    Recenti Prog Med 97:37-45. 2006
    ....
  68. ncbi request reprint Angioprevention': angiogenesis is a common and key target for cancer chemopreventive agents
    Francesca Tosetti
    Molecular Biology Laboratory, National Cancer Research Institute IST, Genova, Italy
    FASEB J 16:2-14. 2002
    ..We analyze the mechanisms on how and why chemopreventive agents could exert antiangiogenic effects aimed at controlling tumor growth, and their potential use in the clinic...
  69. ncbi request reprint Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers
    Frederik Jan van Schooten
    Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands
    Cancer Epidemiol Biomarkers Prev 11:167-75. 2002
    ..1) but not on BAL fluid antioxidant scavenging capacity. We conclude that NAC has the potential to impact upon tobacco smoke carcinogenicity in humans because it can modulate certain cancer-associated biomarkers in specific organs...
  70. ncbi request reprint Mutagenicity of sediments along the Po River and genotoxicity biomarkers in fish from polluted areas
    Luigi Viganò
    Water Research Institute, CNR, I 20047 Brugherio, Milan, Italy
    Mutat Res 515:125-34. 2002
    ..söetta. Thus, certain biomarkers of exposure and effect in fish, as assessed under field conditions, correlate with the pollution of river sediments by mutagenic compounds...
  71. ncbi request reprint Mechanistic approaches to chemoprevention of mutation and cancer
    Lynnette R Ferguson
    The University of Auckland, School of Medical Sciences, Faculty of Medical and Health Sciences, Discipline of Nutrition ACSRC, Private Bag 92019, Auckland 1000, New Zealand
    Mutat Res 591:3-7. 2005
    ..There is increasing reason to believe that the long-term use of a combination of anticarcinogens, over an extended time span, may provide a realistic prospect of reducing the current burden of human cancers...
  72. ncbi request reprint Development of novel cancer chemopreventive agents in Europe--neglected Cinderella or rising phoenix? A critical commentary. ESF Workshop on Cancer Chemoprevention, DKFZ, Heidelberg, September 18-20, 2005
    Clarissa Gerhauser
    German Cancer Research Center, Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Eur J Cancer 42:1338-43. 2006
    ..Overall the workshop aimed at raising awareness among European clinical and laboratory researchers of the importance of the development of novel, efficacious and safe cancer preventive agents...
  73. ncbi request reprint K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke
    Ruisheng Yao
    Department of Surgery and The Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, USA
    Exp Lung Res 31:271-81. 2005
    ..These results suggest that tobacco smoke enhances lung tumorigenesis primarily through promoting spontaneously occurring K-ras mutations...
  74. ncbi request reprint Effects of N-acetylcysteine in an esophageal carcinogenesis model in rats treated with diethylnitrosamine and diethyldithiocarbamate
    Roumen M Balansky
    National Center of Oncology, Sofia, Bulgaria
    Int J Cancer 98:493-7. 2002
    ..The mechanisms underlying enhancement of DEN-induced esophageal carcinogenesis by DEDTC and the protective effects of NAC are discussed...
  75. ncbi request reprint Multiple drug resistance, antimutagenesis and anticarcinogenesis
    Lynnette R Ferguson
    Discipline of Nutrition ACSRC, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Mutat Res 591:24-33. 2005
    ....
  76. ncbi request reprint Interactions between N-acetylcysteine and sodium selenite in modulating the clastogenicity of urethane and 2-acetylaminofluorene in mice
    Roumen M Balansky
    National Center of Oncology, Sofia, Bulgaria
    Int J Cancer 108:158-61. 2004
    ..Together with the findings of previous studies, it appears that, besides its intrinsic protective properties in carcinogenesis, NAC is capable of attenuating the adverse effects of several cytotoxic drugs and chemopreventive agents...
  77. ncbi request reprint Lipid peroxidation-derived etheno-DNA adducts in human atherosclerotic lesions
    Jagadeesan Nair
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mutat Res 621:95-105. 2007
    ....