Raffaele De Caterina

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. ncbi request reprint Prostacyclin improves transcoronary myocardial delivery of adipose tissue-derived stromal cells
    Rosalinda Madonna
    Institute and Postgraduate School of Cardiology, G d Annunzio University Chieti Ospedale San Camillo de Lellis, Via C Forlanini, 50, 66100 Chieti, Italy
    Eur Heart J 27:2054-61. 2006
  2. ncbi request reprint Clinical use of aspirin in ischemic heart disease: past, present and future
    Raffaele De Caterina
    Institute of Cardiology, G d Annunzio University Chieti, C o Ospedale SS Annunziata, Via dei Vestini, 66013 Chieti, Italy
    Curr Pharm Des 18:5215-23. 2012
  3. doi request reprint Vitamin K antagonists in heart disease: current status and perspectives (Section III). Position paper of the ESC Working Group on Thrombosis--Task Force on Anticoagulants in Heart Disease
    Raffaele De Caterina
    Raffaele De Caterina, MD, PhD, Institute of Cardiology, G d Annunzio University Chieti, Ospedale SS Annunziata, Via dei Vestini, 66013 Chieti, Italy, E mail
    Thromb Haemost 110:1087-107. 2013
  4. doi request reprint [Ranolazine in the prevention of anthracycline-related cardiotoxicity]
    Francesco Corradi
    Instituto di Cardiologia, c o Ospedale SS Annuziata, Università degli Studi G d Amunzio, Chieti
    G Ital Cardiol (Rome) 14:424-37. 2013
  5. doi request reprint Parenteral anticoagulants in heart disease: current status and perspectives (Section II). Position paper of the ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease
    R De Caterina
    Institute of Cardiology, G d Annunzio University Chieti, Ospedale SS Annunziata, Via dei Vestini, Chieti, Italy
    Thromb Haemost 109:769-86. 2013
  6. doi request reprint General mechanisms of coagulation and targets of anticoagulants (Section I). Position Paper of the ESC Working Group on Thrombosis--Task Force on Anticoagulants in Heart Disease
    Raffaele De Caterina
    Institute of Cardiology, G d Annunzio University Chieti, Ospedale SS Annunziata, Via dei Vestini, 66013 Chieti, Italy
    Thromb Haemost 109:569-79. 2013
  7. doi request reprint [Dabigatran as an alternative to warfarin for the prevention of thromboembolism in atrial fibrillation]
    Raffaele De Caterina
    Istituto di Cardiologia e Centro di Eccellenza Studi sull Invecchiamento Ce S I, Universita degli Studi G D Annunzio, Chieti, Italy
    G Ital Cardiol (Rome) 13:19S-27S. 2012
  8. doi request reprint New oral anticoagulants in atrial fibrillation and acute coronary syndromes: ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease position paper
    Raffaele De Caterina
    G D Annunzio University, Chieti, Italy
    J Am Coll Cardiol 59:1413-25. 2012
  9. doi request reprint Hepatocyte growth factor: molecular biomarker and player in cardioprotection and cardiovascular regeneration
    R Madonna
    Institute of Cardiology, G d Annunzio University Chieti, C o Ospedale SS Annunziata, Via dei Vestini, 66013 Chieti, Italy
    Thromb Haemost 107:656-61. 2012
  10. ncbi request reprint Omega-3 fatty acids, atherogenesis, and endothelial activation
    Raffaele De Caterina
    G D Annunzio University, Chieti, Italy
    J Cardiovasc Med (Hagerstown) 8:S11-4. 2007

Detail Information

Publications114 found, 100 shown here

  1. ncbi request reprint Prostacyclin improves transcoronary myocardial delivery of adipose tissue-derived stromal cells
    Rosalinda Madonna
    Institute and Postgraduate School of Cardiology, G d Annunzio University Chieti Ospedale San Camillo de Lellis, Via C Forlanini, 50, 66100 Chieti, Italy
    Eur Heart J 27:2054-61. 2006
    ..We investigated the engraftment and influence on cardiac function of the transcoronary delivery of ADSCs and the effects of PGI2 compared with nitroglycerin (NTG) and adenosine (Ado) in isolated-perfused mouse hearts...
  2. ncbi request reprint Clinical use of aspirin in ischemic heart disease: past, present and future
    Raffaele De Caterina
    Institute of Cardiology, G d Annunzio University Chieti, C o Ospedale SS Annunziata, Via dei Vestini, 66013 Chieti, Italy
    Curr Pharm Des 18:5215-23. 2012
    ....
  3. doi request reprint Vitamin K antagonists in heart disease: current status and perspectives (Section III). Position paper of the ESC Working Group on Thrombosis--Task Force on Anticoagulants in Heart Disease
    Raffaele De Caterina
    Raffaele De Caterina, MD, PhD, Institute of Cardiology, G d Annunzio University Chieti, Ospedale SS Annunziata, Via dei Vestini, 66013 Chieti, Italy, E mail
    Thromb Haemost 110:1087-107. 2013
    ....
  4. doi request reprint [Ranolazine in the prevention of anthracycline-related cardiotoxicity]
    Francesco Corradi
    Instituto di Cardiologia, c o Ospedale SS Annuziata, Università degli Studi G d Amunzio, Chieti
    G Ital Cardiol (Rome) 14:424-37. 2013
    ....
  5. doi request reprint Parenteral anticoagulants in heart disease: current status and perspectives (Section II). Position paper of the ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease
    R De Caterina
    Institute of Cardiology, G d Annunzio University Chieti, Ospedale SS Annunziata, Via dei Vestini, Chieti, Italy
    Thromb Haemost 109:769-86. 2013
    ..Using an evidence-based approach, we describe the results of completed clinical trials, highlight ongoing research with currently available agents, and recommend therapeutic options for specific heart diseases...
  6. doi request reprint General mechanisms of coagulation and targets of anticoagulants (Section I). Position Paper of the ESC Working Group on Thrombosis--Task Force on Anticoagulants in Heart Disease
    Raffaele De Caterina
    Institute of Cardiology, G d Annunzio University Chieti, Ospedale SS Annunziata, Via dei Vestini, 66013 Chieti, Italy
    Thromb Haemost 109:569-79. 2013
    ..A number of new anticoagulants, already developed or under development, target specific steps in the process, inhibiting a single coagulation factor or mimicking natural coagulation inhibitors...
  7. doi request reprint [Dabigatran as an alternative to warfarin for the prevention of thromboembolism in atrial fibrillation]
    Raffaele De Caterina
    Istituto di Cardiologia e Centro di Eccellenza Studi sull Invecchiamento Ce S I, Universita degli Studi G D Annunzio, Chieti, Italy
    G Ital Cardiol (Rome) 13:19S-27S. 2012
    ..There is also a need for assessing their long-term efficacy and safety over decades in the real-world setting...
  8. doi request reprint New oral anticoagulants in atrial fibrillation and acute coronary syndromes: ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease position paper
    Raffaele De Caterina
    G D Annunzio University, Chieti, Italy
    J Am Coll Cardiol 59:1413-25. 2012
    ..Although convenient to administer and manage, they present challenges that need to be addressed...
  9. doi request reprint Hepatocyte growth factor: molecular biomarker and player in cardioprotection and cardiovascular regeneration
    R Madonna
    Institute of Cardiology, G d Annunzio University Chieti, C o Ospedale SS Annunziata, Via dei Vestini, 66013 Chieti, Italy
    Thromb Haemost 107:656-61. 2012
    ..Here we discuss the role of HGF as a biomarker and mediator in cardioprotection and cardiovascular regeneration...
  10. ncbi request reprint Omega-3 fatty acids, atherogenesis, and endothelial activation
    Raffaele De Caterina
    G D Annunzio University, Chieti, Italy
    J Cardiovasc Med (Hagerstown) 8:S11-4. 2007
    ..Decreased atherogenesis is currently thought to account at least in part for cardiovascular protection by n-3 PUFAs. We summarise the evidence for such effects and the putative mechanisms involved...
  11. doi request reprint Sulfido-peptide leukotrienes in coronary heart disease - relationship with disease instability and myocardial ischaemia
    R De Caterina
    C N R Institute of Clinical Physiology, Pisa, Italy
    Eur J Clin Invest 40:258-72. 2010
    ..Enhanced LTC(4) biosynthesis may be a consequence of myocardial ischaemia or be linked to its pathogenetic substrate...
  12. ncbi request reprint Anticoagulants in heart disease: current status and perspectives
    Raffaele De Caterina
    Institute of Cardiology, G d Annunzio University Chieti, Ospedale S Camillo de Lellis, Chieti, Italy
    Eur Heart J 28:880-913. 2007
  13. ncbi request reprint n-3 fatty acids in the treatment of diabetic patients: biological rationale and clinical data
    Raffaele De Caterina
    Institute of Cardiology, G D Annunzio University, Chieti, Italy
    Diabetes Care 30:1012-26. 2007
  14. ncbi request reprint Nutritional mechanisms that influence cardiovascular disease
    Raffaele De Caterina
    Institute of Cardiology, University Cardiology Division, and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy, Italy
    Am J Clin Nutr 83:421S-426S. 2006
    ..This review will summarize the mechanisms by which diet may influence atherogenesis through the early inception, progression, and clinical emergence of atherosclerosis, with a special focus on n-3 fatty acids...
  15. ncbi request reprint Omega-3 fatty acids and the regulation of expression of endothelial pro-atherogenic and pro-inflammatory genes
    R De Caterina
    G D Annunzio University, Chieti, Italy
    J Membr Biol 206:103-16. 2005
    ....
  16. ncbi request reprint Nutrients and gene expression
    Raffaele De Caterina
    Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    World Rev Nutr Diet 93:99-133. 2004
  17. doi request reprint New anticoagulants for atrial fibrillation
    Raffaele De Caterina
    Institute of Cardiology and Center of Excellence on Aging, G d Annunzio University Chieti, Italy
    J Cardiovasc Med (Hagerstown) 10:446-53. 2009
    ..Cardiologists need to be aware of the explosive pharmacological literature being accrued with these new drugs, as most of these will likely enter the clinical arena in the near future...
  18. doi request reprint The current role of anticoagulants in cardiovascular medicine
    Raffaele De Caterina
    Institute of Cardiology, Gabriele d Annunzio University, Chieti, Italy bCNR Institute of Clinical Physiology, Pisa, Italy
    J Cardiovasc Med (Hagerstown) 10:595-604. 2009
    ..A large unmet need exists for new convenient and well-tolerated oral anticoagulants that do not require routine monitoring...
  19. doi request reprint Cholesterol-lowering interventions and stroke: insights from a meta-analysis of randomized controlled trials
    Raffaele De Caterina
    Institute of Cardiology and University Cardiology Division, G D Annunzio University, Chieti, Italy
    J Am Coll Cardiol 55:198-211. 2010
    ..This meta-analysis was performed to determine the effects of various cholesterol-lowering treatments on the risk of stroke and its relationship with the extent of cholesterol lowering...
  20. doi request reprint Glycaemic control in acute coronary syndromes: prognostic value and therapeutic options
    Raffaele De Caterina
    Institute of Cardiology and Center of Excellence on Aging, G d Annunzio University Chieti, C o Ospedale SS Annunziata, Via dei Vestini, I 66013 Chieti, Italy
    Eur Heart J 31:1557-64. 2010
    ..Such drugs should be known by practicing cardiologists for their possible use in ICUs in the years to come...
  21. doi request reprint Mortality predictors and effects of antithrombotic therapies in atrial fibrillation: insights from ACTIVE-W
    Raffaele De Caterina
    Institute of Cardiology, G D Annunzio University, C o Ospedale SS Annunziata, Via dei Vestini, 66013 Chieti, Italy
    Eur Heart J 31:2133-40. 2010
    ..Antithrombotic therapies in AF have primarily focused on stroke prevention and bleeding. However, strokes and bleeds differ in severity, and the level of severity may differently impact mortality...
  22. doi request reprint Long-term use of anti-inflammatory drugs and risk of atrial fibrillation
    Raffaele De Caterina
    Institute of Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    Arch Intern Med 170:1450-5. 2010
    ..We sought to determine the existence of a similar association for non-SAIDs (NSAIDs)...
  23. doi request reprint Pharmacological modulation of vascular inflammation in atherothrombosis
    Raffaele De Caterina
    Institute of Cardiology, G D Annunzio University, Chieti, Italy
    Ann N Y Acad Sci 1207:23-31. 2010
    ..Old" drugs, such as dipyridamole, can also now be revisited for properties related to inhibition of vascular inflammation, probably by acting on the common hub of inflammation...
  24. doi request reprint Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction
    Raffaele De Caterina
    Institute of Cardiology and Center of Excellence on Aging, G d Annunzio University Chieti and Fondazione G Monasterio, Pisa, Italy
    Atherosclerosis 214:397-403. 2011
    ..Epidemiological studies support the role for a strong genetic component in the occurrence of early-onset myocardial infarction (MI), although the specific genetic variants responsible for familial clustering remain largely unknown...
  25. doi request reprint Stroke prevention in atrial fibrillation: current status and near-future directions
    Raffaele De Caterina
    Institute of Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    Am J Med 124:793-9. 2011
    ..These highlight the need for new anticoagulants in atrial fibrillation. The novel oral anticoagulants in development may overcome some of the limitations of vitamin K antagonists and address their underuse and safety concerns...
  26. ncbi request reprint Effects of omega-3 fatty acids on cytokines and adhesion molecules
    Raffaele De Caterina
    Institute of Cardiology, G d Annunzio University Chieti, C o Ospedale S Camillo de Lellis, Via Forlanini 50, 66100 Chieti, Italy
    Curr Atheroscler Rep 6:485-91. 2004
    ....
  27. ncbi request reprint [Antiarrhythmia effects of omega-3 fatty acids. A review]
    Raffaele De Caterina
    Cattedra di Cardiologia, Universita degli Studi G D Annunzio, Chieti
    Ital Heart J Suppl 3:297-308. 2002
    ..This review critically summarizes this type of evidence and indicates current research directions for its further validation...
  28. ncbi request reprint Antiarrhythmic effects of omega-3 fatty acids: from epidemiology to bedside
    Raffaele De Caterina
    University Cardiology Division, G D Annunzio University, Chieti, Italy
    Am Heart J 146:420-30. 2003
    ..This review summarizes the epidemiological background for the use of omega-3 fatty acids with this indication, clinical trials performed so far, and experimental data supporting their antiarrhythmic efficacy...
  29. ncbi request reprint Low-density lipoprotein level reduction by the 3-hydroxy-3-methylglutaryl coenzyme-A inhibitor simvastatin is accompanied by a related reduction of F2-isoprostane formation in hypercholesterolemic subjects: no further effect of vitamin E
    Raffaele De Caterina
    Chair of Cardiology, G D Annunzio University, Chieti, Italy
    Circulation 106:2543-9. 2002
    ..Both statins and vitamin E, by reducing the rate of lipid peroxidation, may interfere with oxidative stress, but the impact of their combination is unknown...
  30. ncbi request reprint Low-dose aspirin in the primary prevention of cardiovascular disease: how to balance the benefits and the risks
    Raffaele De Caterina
    G D Annunzio University, Chieti, Italy
    Ital Heart J 4:228-31. 2003
    ..We will here review the reasoning which should be at the basis of a set of recommendations, as recently expressed by two American expert opinion panels...
  31. ncbi request reprint New cardiovascular risk factors: homocysteine and vitamins involved in homocysteine metabolism
    Raffaele De Caterina
    Division of Cardiology, G D Annunzio University, Chieti, Italy
    Ital Heart J 5:19S-24S. 2004
    ..The results of a recent study of ours, with a long follow-up, indeed suggest that homocysteine and vitamin B6 are independent and additive cardiovascular risk factors...
  32. ncbi request reprint n-3 fatty acids: antiatherosclerotic effects
    R De Caterina
    Department of Cardiology, G D Annunzio University, Chieti, Italy
    Lipids 36:S69-78. 2001
    ..This paper reviews published literature on n-3 fatty acids and atherosclerosis in animal models and in humans and in vitro experimental data yielding suport to the hypothesis of antiatherosclerotic effects of these substances...
  33. pmc Inconsistency of different methods for assessing ex vivo platelet function: relevance for the detection of aspirin resistance
    Giulia Renda
    The Institute of Cardiology and Center of Excellence on Aging at G d Annunzio University, Chieti, Italy
    Haematologica 95:2095-101. 2010
    ..Assays to evaluate platelet function are often interchangeably used to assess "resistance" to aspirin. We compared different platelet function assays in patients treated or untreated with aspirin...
  34. doi request reprint Defective recovery of QT dispersion predicts late cardiac mortality after percutaneous coronary intervention
    Marco Zimarino
    Institute of Cardiology and Center of Excellence on Ageing, G D Annunzio University, Chieti, Ospedale SS Annunziata, Via dei Vestini, 30, Chieti 66013, Italy
    Heart 97:466-72. 2011
    ..It has been suggested that corrected QT dispersion (cQTD) provides a measure of repolarisation inhomogeneity; however, the existence of a relationship between cQTD and cardiac outcomes is controversial...
  35. ncbi request reprint Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts
    Pericle Di Napoli
    Laboratory of Experimental Cardiology, Department of Clinical Sciences and Bioimaging, and Center of Excellence of Aging, G D Annunzio University, Chieti, Italy
    Cardiovasc Res 66:462-71. 2005
    ....
  36. doi request reprint Effect of the administration of n-3 polyunsaturated fatty acids on circulating levels of microparticles in patients with a previous myocardial infarction
    Serena Del Turco
    CNR Institute of Clinical Physiology, Pisa, Italy
    Haematologica 93:892-9. 2008
    ....
  37. ncbi request reprint Prolonged exposure to high insulin impairs the endothelial PI3-kinase/Akt/nitric oxide signalling
    Rosalinda Madonna
    Institute of Cardiology, G d Annunzio University Chieti, C o Ospedale Clinicizzato SS Annunziata, Via dei Vestini, 66013 Chieti, Italy
    Thromb Haemost 101:345-50. 2009
    ..Such impairment of insulin signalling in states of prolonged hyperinsulinemia pontially contributes to detrimental effects on atherogenesis in insulin resistance states, such as the metabolic syndrome and type 2 diabetes...
  38. ncbi request reprint Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals
    Maria Annunziata Carluccio
    C N R Institute of Clinical Physiology, Lecce, Italy
    Arterioscler Thromb Vasc Biol 23:622-9. 2003
    ..Because monocyte adhesion to the endothelium is crucial in early atherogenesis, we evaluated whether typical olive oil and red wine polyphenols affect endothelial-leukocyte adhesion molecule expression and monocyte adhesion...
  39. doi request reprint Insulin potentiates cytokine-induced VCAM-1 expression in human endothelial cells
    Rosalinda Madonna
    Institute of Cardiology, Center of Excellence on Aging, G d Annunzio University Chieti, Italy
    Biochim Biophys Acta 1782:511-6. 2008
    ..Therefore, hyperinsulinemia enhances cytokine-induced VCAM-1 expression in endothelial cells, thus potentially contributing to detrimental effects of other inflammatory stimuli on atherogenesis...
  40. ncbi request reprint Awake systolic blood pressure variability correlates with target-organ damage in hypertensive subjects
    Alfonso Tatasciore
    Institute of Cardiology, Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    Hypertension 50:325-32. 2007
    ..Such relationship, found in subjects referred for recently suspected hypertension, likely appears early in the natural history of hypertension...
  41. ncbi request reprint Magnetocardiography: current status and perspectives. Part II: Clinical applications
    Isabella Tavarozzi
    Chair of Cardiology, Institute of Advanced Biomedical Technologies, G D Annunzio University, Chieti, Italy
    Ital Heart J 3:151-65. 2002
    ..This second part is devoted to the description of the main current clinical applications and perspectives...
  42. ncbi request reprint Effect of chronic hypoxia on inducible nitric oxide synthase expression in rat myocardial tissue
    Alfredo Grilli
    Department of Biomorphology, University G D Annunzio, 66013 Chieti, Italy
    Exp Biol Med (Maywood) 228:935-42. 2003
    ..1 +/- 0.01 vs 0.02 +/- 0.003). The present study shows that exposure to low oxygen tension is capable of inducing programmed cell death and activating iNOS...
  43. ncbi request reprint Surgical bleeding after pre-operative unfractionated heparin and low molecular weight heparin for coronary bypass surgery
    Giulia Renda
    Institute of Cardiology, G D Annunzio University, Chieti, Italy
    Haematologica 92:366-73. 2007
    ....
  44. ncbi request reprint Vasculoprotective potential of olive oil components
    Maria Annunziata Carluccio
    C N R Institute of Clinical Physiology, Pisa, Italy
    Mol Nutr Food Res 51:1225-34. 2007
    ..The available data support the need to preserve certain dietary traditions, such as olive oil consumption, to counteract the burden of cardiovascular disease...
  45. ncbi request reprint At least 2 distinct pathways generating reactive oxygen species mediate vascular cell adhesion molecule-1 induction by advanced glycation end products
    Giuseppina Basta
    C N R Institutes of Clinical Physiology, Pisa, Italy
    Arterioscler Thromb Vasc Biol 25:1401-7. 2005
    ..We investigated the role of distinct sources of ROS, including the mitochondrial electron transport chain, NAD(P)H oxidase, xanthine oxidase, and arachidonic acid metabolism, in AGE-induced VCAM-1 expression...
  46. ncbi request reprint Left ventricular wall stress as a direct correlate of cardiomyocyte apoptosis in patients with severe dilated cardiomyopathy
    Pericle Di Napoli
    Laboratory of Experimental Cardiology, Department of Clinical Sciences and Bioimaging, Chieti, Italy
    Am Heart J 146:1105-11. 2003
    ....
  47. ncbi request reprint Parallel decrease of tissue factor surface exposure and increase of tissue factor microparticle release by the n-3 fatty acid docosahexaenoate in endothelial cells
    Serena Del Turco
    C N R Institute of Clinical Physiology, Pisa, Italy
    Thromb Haemost 98:210-9. 2007
    ....
  48. ncbi request reprint Trimetazidine improves post-ischemic recovery by preserving endothelial nitric oxide synthase expression in isolated working rat hearts
    Pericle Di Napoli
    Laboratory of Experimental Cardiology, Department of Clinical Science and Bioimaging, Biology Section, University of Chieti, Chieti, Italy
    Nitric Oxide 16:228-36. 2007
    ..We tested the hypothesis that cardioprotective effect of TMZ is partly mediated by preservation of the endothelial barrier of the coronary microcirculation...
  49. ncbi request reprint Celecoxib, ibuprofen, and the antiplatelet effect of aspirin in patients with osteoarthritis and ischemic heart disease
    Giulia Renda
    Departments of Medicine and Clinical Sciences, Center of Excellence on Aging, G D Annunzio University, School of Medicine, Chiete, Italy
    Clin Pharmacol Ther 80:264-74. 2006
    ....
  50. pmc Aspirin-triggered lipoxin in patients treated with aspirin and selective vs. nonselective COX-2 inhibitors
    Giulia Renda
    G D Annunzio University, Chieti, Italy
    Br J Clin Pharmacol 69:303-6. 2010
    ..We tested the hypothesis that the co-administration of aspirin with either the selective COX-2 inhibitor celecoxib or the nonselective COX inhibitor ibuprofen reduces ATL biosynthesis...
  51. ncbi request reprint Short-term prevention of thromboembolic complications in patients with atrial fibrillation with aspirin plus clopidogrel: the Clopidogrel-Aspirin Atrial Fibrillation (CLAAF) pilot study
    Roberto Lorenzoni
    Department of Cardiology, Campo di Marte Hospital, Lucca, Italy
    Am Heart J 148:e6. 2004
    ..We evaluated the short-term safety and efficacy of aspirin-plus-clopidogrel as antithrombotic therapy in nonvalvular atrial fibrillation (AF)...
  52. doi request reprint Impact of antiplatelet therapy in heart disease
    Giulia Renda
    Institute of Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    Adv Cardiol 47:5-19. 2012
    ..This chapter provides a general overview of the use of antiplatelet agents in heart disease...
  53. doi request reprint Increased basal coronary blood flow as a cause of reduced coronary flow reserve in diabetic patients
    Andrea Picchi
    Department of Cardiology, Misericordia Hospital, Grosseto, Italy
    Am J Physiol Heart Circ Physiol 301:H2279-84. 2011
    ..Basal coronary flow relates to insulin resistance, suggesting a key role of cellular metabolism in the regulation of coronary blood flow...
  54. doi request reprint Basic mechanisms behind the effects of n-3 fatty acids on cardiovascular disease
    Marika Massaro
    C N R Institute of Clinical Physiology, Pisa and Lecce, Italy University of Lecce, Ecotekne, Lecce, Italy
    Prostaglandins Leukot Essent Fatty Acids 79:109-15. 2008
    ..All together, these mechanisms may provide an integrated view of how n-3 FA may affect CVD...
  55. doi request reprint Increased short-term blood pressure variability is associated with early left ventricular systolic dysfunction in newly diagnosed untreated hypertensive patients
    Alfonso Tatasciore
    Institute of Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti
    J Hypertens 31:1653-61. 2013
    ..We tested the hypothesis that short-term BP variability (BPV) is also related to subclinical left ventricular systolic dysfunction...
  56. ncbi request reprint [Biology and physiopathology of tissue factor and its relevance for cardiovascular diseases]
    Serena Del Turco
    Cattedra di Cardiologia, Universita degli Studi G D Annunzio, Chieti
    Ital Heart J Suppl 4:559-68. 2003
    ..This observation suggests a new view of thrombosis that does not necessarily require the exposure of vessel wall-derived TF at the site of vascular injury to initiate and propagate thrombosis...
  57. ncbi request reprint [Myocardial infarction with normal coronary arteries: a condition with multiple etiology and variable prognosis]
    Isabella Kardasz
    Istituto di Cardiologia e Centro di Eccellenza sull Invecchiamento, Universita degli Studi G D Annunzio, Chieti e Istituto di Fisiologia Clinica del CNR, Pisa
    G Ital Cardiol (Rome) 7:474-86. 2006
    ..This review summarizes current knowledge on this condition and examines areas of recent progress...
  58. ncbi request reprint Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts
    Rosalinda Madonna
    Institute of Cardiology and Center of Excellence on Aging, G d Annuzio Univeristy, Chieti, Italy
    J Biol Chem 280:13503-11. 2005
    ..These data suggest that statin therapy may protect the cardiac myocyte progenitors against the cytotoxicity of cytokine-induced high output of NO production in infarcted or ischemic hearts with inflammation...
  59. doi request reprint Omega-3 fatty acids attenuate constitutive and insulin-induced CD36 expression through a suppression of PPAR α/γ activity in microvascular endothelial cells
    Rosalinda Madonna
    G D Annunzio University, Chieti, Italy
    Thromb Haemost 106:500-10. 2011
    ..In conclusion, omega-3 fatty acids blunt the increased CD36 expression and activity promoted by high concentrations of insulin. Such mechanisms may be the basis for the use of omega-3 fatty acids in diabetic microvasculopathy...
  60. ncbi request reprint [Group B vitamins as new variables related to the cardiovascular risk]
    Monica Granieri
    Istituto di Cardiologia, Universita degli Studi G D Annunzio, Chieti
    Ital Heart J Suppl 6:1-16. 2005
    ..A further confirmation of these data is important to devise future intervention strategies in primary and secondary prophylaxis of atherosclerotic vascular disease...
  61. doi request reprint Dipyridamole decreases inflammatory metalloproteinase-9 expression and release by human monocytes
    Marika Massaro
    C N R Institute of Clinical Physiology, Pisa and Lecce, Italy
    Thromb Haemost 109:280-9. 2013
    ..These results indicate that dipyridamole exerts anti-inflammatory properties in human monocytes that may favourably contribute to its actions in the secondary prevention of stroke, independent of its antiplatelet properties...
  62. ncbi request reprint Rapid decline of collateral circulation increases susceptibility to myocardial ischemia: the trade-off of successful percutaneous recanalization of chronic total occlusions
    Marco Zimarino
    Institute of Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    J Am Coll Cardiol 48:59-65. 2006
    ....
  63. ncbi request reprint Pathophysiology of ischemia-reperfusion injury: experimental data
    Pericle Di Napoli
    Chair of Cardiology, and Laboratory of Experimental Cardiology, Department of Clinical Sciences and Bioimaging, G D Annunzio University, Chieti
    Ital Heart J 3:24S-28S. 2002
  64. ncbi request reprint Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes
    Giuseppina Basta
    CNR Institute of Clinical Physiology, Pisa, Italy
    Cardiovasc Res 63:582-92. 2004
    ..Thus, a better understanding of the biochemical mechanisms by which AGEs contribute to such processes in the vessel wall could be relevant to devise preventive and therapeutic strategies for diabetic atherosclerosis...
  65. doi request reprint Patient management and care after primary percutaneous coronary intervention: reinforcing a continuum of care after primary percutaneous coronary intervention
    Marco Zimarino
    Institute of Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    Am Heart J 160:S42-7. 2010
    ....
  66. doi request reprint In vitro neovasculogenic potential of resident adipose tissue precursors
    Rosalinda Madonna
    Cardiology Division and Center of Excellence on Aging, G d Annunzio Univ Chieti, C o Ospedale SS Annunziata, Via dei Vestini, 66013 Chieti, Italy
    Am J Physiol Cell Physiol 295:C1271-80. 2008
    ..The developing adipose tissue has neovasculogenic potential, based on the recruitment of local rather than circulating progenitors. Adipose tissue might therefore be a viable autonomous source of cells for postnatal neovascularization...
  67. ncbi request reprint Quenching of intracellular ROS generation as a mechanism for oleate-induced reduction of endothelial activation and early atherogenesis
    Marika Massaro
    Laboratory for Thrombosis and Vascular Research, C N R Institute of Clinical Physiology, Pisa, Italy
    Thromb Haemost 88:335-44. 2002
    ..These results indicate that oleate may exert direct vascular atheroprotective effects by inhibiting endothelial activation through a quenching of stimuli-induced increase in ROS...
  68. doi request reprint Cellular and molecular mechanisms of vascular injury in diabetes--part I: pathways of vascular disease in diabetes
    Rosalinda Madonna
    Institute of Cardiology, G d Annunzio University Chieti, Italy
    Vascul Pharmacol 54:68-74. 2011
    ....
  69. ncbi request reprint Late coronary thrombosis after drug-eluting stent: stent vs patient-driven prescription of aspirin-clopidogrel combination
    Marco Zimarino
    Institute of Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    Thromb Haemost 92:668-9. 2004
  70. doi request reprint Adipose tissue-derived stem cells: characterization and potential for cardiovascular repair
    Rosalinda Madonna
    Institute of Cardiology, G D Annunzio University, Chieti, Italy
    Arterioscler Thromb Vasc Biol 29:1723-9. 2009
    ....
  71. doi request reprint Circulating soluble receptor of advanced glycation end product inversely correlates with atherosclerosis in patients with chronic kidney disease
    Giuseppina Basta
    CNR Institute of Clinical Physiology, Pisa, Italy
    Kidney Int 77:225-31. 2010
    ..The pathophysiological significance of this correlation will have to await more mechanistic studies...
  72. doi request reprint Plasma N-epsilon-(carboxymethyl)lysine levels are associated with the extent of vessel injury after coronary arterial stenting
    Giuseppina Basta
    CNR, Institute of Clinical Physiology, Pisa, Massa, Italy
    Coron Artery Dis 19:299-305. 2008
    ..In patients undergoing percutaneous coronary interventions with stenting, we investigated whether plasma levels of CML and the soluble form of receptor for advanced glycation end products (sRAGE) changed during poststenting follow-up...
  73. doi request reprint 'Missing' coronary arteries at urgent coronary angiography for ST-elevation myocardial infarction
    Marco Zimarino
    Institute of Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    J Cardiovasc Med (Hagerstown) 11:754-7. 2010
    ..The knowledge and the identification of coronary artery anomalies have extreme clinical relevance in urgent angiography for STEMI patients...
  74. ncbi request reprint Optimal duration of antiplatelet therapy in recipients of coronary drug-eluting stents
    Marco Zimarino
    Institute of Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    Drugs 65:725-32. 2005
    ..Therefore, we propose that prolonged combination therapy with aspirin and clopidogrel be mandatory up to 1 year after PCI in all patients receiving DES...
  75. ncbi request reprint Inverse association between carotid intima-media thickness and the antioxidant lycopene in atherosclerosis
    Jacopo Gianetti
    C N R Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Am Heart J 143:467-74. 2002
    ....
  76. doi request reprint Receiver operating characteristic (ROC) curves and the definition of threshold levels to diagnose coronary artery disease on electrocardiographic stress testing. Part II: the use of ROC curves in the choice of electrocardiographic stress test markers of i
    Stefania Marazia
    Institute of Cardiology, G D Annunzio University, Chieti, Italy
    J Cardiovasc Med (Hagerstown) 9:22-31. 2008
    ..Part II will be devoted to the comparative analysis of various parameters derived from exercise stress testing for the diagnosis of underlying coronary artery disease...
  77. ncbi request reprint Non-invasive in vivo detection of peripheral limb ischemia improvement in the rat after adipose tissue-derived stromal cell transplantation
    Rosalinda Madonna
    Cardiology Division and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    Circ J 76:1517-25. 2012
    ..Adipose tissue-derived stromal cells (ADSCs) might help repair ischemic cardiovascular tissue. Their in vivo effects on the bioenergetics and microcirculation of ischemic muscle through a variety of non-invasive techniques was examined...
  78. doi request reprint Genetic determinants of blood pressure responses to caffeine drinking
    Giulia Renda
    Institute of Cardiology, Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    Am J Clin Nutr 95:241-8. 2012
    ..The widely observed between-subject variability in cardiovascular responses to coffee may have a genetic basis...
  79. ncbi request reprint Glycoprotein IIb-IIIa antagonists in non-ST elevation acute coronary syndromes and percutaneous interventions: from pharmacology to individual patient's therapy: Part 2: When and how to use various agents
    Marco Zimarino
    Institute of Cardiology, G D Annunzio University, Chieti, Italy
    J Cardiovasc Pharmacol 43:477-84. 2004
    ..Here we propose an algorithm for the practical use of available GPIIb/IIIa antagonists in relation with the patient's clinical presentation and concomitant use of other drugs and devices...
  80. doi request reprint Facilitated PCI: rationale, current evidence, open questions, and future directions
    Marco Zimarino
    Institute of Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    J Cardiovasc Pharmacol 51:3-10. 2008
    ..In patients having first medical contact within 3 hours, with an anticipated absolute delay to PCI of more than 90 minutes, thrombolysis can be safely recommended...
  81. doi request reprint Cellular and molecular mechanisms of vascular injury in diabetes--part II: cellular mechanisms and therapeutic targets
    Rosalinda Madonna
    Institute of Cardiology, G D Annunzio University, Chieti, Italy
    Vascul Pharmacol 54:75-9. 2011
    ..Here we summarize the evidence for such an occurrence. We also here highlight how new insights into pathways of vascular damage in diabetes may indicate new targets for preventive and treatment strategies...
  82. doi request reprint Nutraceuticals and prevention of atherosclerosis: focus on omega-3 polyunsaturated fatty acids and Mediterranean diet polyphenols
    Marika Massaro
    CNR Institute of Clinical Physiology, Pisa, Lecce, Italy
    Cardiovasc Ther 28:e13-9. 2010
    ....
  83. doi request reprint Adipose tissue: a new source for cardiovascular repair
    Rosalinda Madonna
    Institute of Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    J Cardiovasc Med (Hagerstown) 11:71-80. 2010
    ..In this review we discuss molecular and functional characterization, preclinical results and currently ongoing clinical trials using adipose-derived stem cells in cardiovascular repair...
  84. pmc Early restenosis after drug-eluting stent implantation: A putative role for platelet activation
    Corrado Tamburino
    Institute of Cardiology, Ferrarotto Hospital, University of Catania, Italy
    Can J Cardiol 23:57-9. 2007
    ..Extremely careful follow-up is mandatory after the recognition of intraluminal thrombi inside DES because restenosis may occur at the same site of DES thrombosis...
  85. ncbi request reprint From asthma to atherosclerosis--5-lipoxygenase, leukotrienes, and inflammation
    Raffaele De Caterina
    Division of Cardiology and the Center of Excellence on Aging, Gabriele d Annunzio University, Chieti, Italy
    N Engl J Med 350:4-7. 2004
  86. ncbi request reprint [Unusual case of interventricular septal defect in tertiary syphilis]
    Pericle Di Napoli
    Dipartimento di Riabilitazione Cardiologica Casa di Cura Villa Pini d Abruzzo Via dei Frentani, 224 66100 Chieti
    Ital Heart J Suppl 3:112-4. 2002
  87. ncbi request reprint Expert consensus document on the use of antiplatelet agents. The task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European society of cardiology
    Carlo Patrono
    ESC Task Force on Antiplatelets, University of Rome La Sapienza, II Facolta di Medicina e Chirurgia, Via di Grottarossa, 1035, 00189 Roma, Italy
    Eur Heart J 25:166-81. 2004
  88. ncbi request reprint Glycoprotein IIb-IIIa antagonists in non-ST elevation acute coronary syndromes and percutaneous interventions: from pharmacology to individual patient's therapy: part 1: the evidence of benefit
    Marco Zimarino
    Institute of Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    J Cardiovasc Pharmacol 43:325-32. 2004
    ..This article summarizes reasons for the ongoing debate on their efficacy and highlights areas of uncertainty...
  89. doi request reprint Antihypertensive and metabolic effects of telmisartan in hypertensive HIV-positive patients
    Jacopo Vecchiet
    Division of Infectious Diseases, Department of Medicine and Sciences of Aging, G d Annunzio University School of Medicine, Chieti, Italy
    Antivir Ther 16:639-45. 2011
    ..The aim of this study was to evaluate the antihypertensive and metabolic effects of telmisartan in hypertensive HIV-positive patients...
  90. ncbi request reprint Optical coherence tomography accurately identifies intermediate atherosclerotic lesions--an in vivo evaluation in the rabbit carotid artery
    Marco Zimarino
    Institute of Cardiology and Centre of Excellence, G d Annunzio University Chieti, Ospedale S Camillo de Lellis, Via Forlanini 50, 66100 Chieti, Italy
    Atherosclerosis 193:94-101. 2007
    ..We tested the ability of optical coherence tomography (OCT) to identify very early stages of atherosclerosis in vivo...
  91. ncbi request reprint Intraoperative ischemia and long-term events after minimally invasive coronary surgery
    Marco Zimarino
    Department of Cardiology and Cardiac Surgery, G D Annunzio University of Chieti, Italy
    Ann Thorac Surg 78:135-41. 2004
    ..We sought to assess the impact of myocardial dysfunction during MIDCABG on long-term outcome and the protective role of collateral circulation on myocardial ischemia...
  92. ncbi request reprint [Expert consensus document on the use of antiplatelet agents]
    Carlo Patrono
    Rev Esp Cardiol 57:963-80. 2004
  93. ncbi request reprint Role of nutrients and physical activity in gene expression
    Raffaele De Caterina
    Institute of Cardiology and Center of Excellence on Aging, G D Annunzio University, Chieti, Italy
    World Rev Nutr Diet 94:107-19. 2005
  94. ncbi request reprint Complete myocardial revascularization: between myth and reality
    Marco Zimarino
    Institute of Cardiology and Centre of Excellence on Aging, G D Annunzio University, Ospedale S Camillo de Lellis, Via Forlanini, 50, 66100 Chieti, Italy
    Eur Heart J 26:1824-30. 2005
    ..The patient's clinical status, ventricular function, and the presence of co-morbidities may orient clinical decisions in favour of incomplete revascularization...
  95. ncbi request reprint Regulation of endothelial function in coronary microcirculation by HMG-CoA reductase drugs
    Pericle Di Napoli
    Laboratory of Experimental Cardiology, Department of Clinical Sciences and Bioimaging, G D Annunzio University, Chieti
    Ital Heart J 3:20S-23S. 2002
  96. pmc Hepatocyte growth factor/Met gene transfer in cardiac stem cells--potential for cardiac repair
    Rosalinda Madonna
    Institute of Molecular Cardiology, University of Louisville, Louisville, KY, USA
    Basic Res Cardiol 105:443-52. 2010
    ..Here, we discuss the possible application of HGF/Met gene therapy to enhance the ability of CSCs to promote myocardial regeneration...
  97. ncbi request reprint Inducible nitric oxide synthase and heme oxygenase-1 in rat heart: direct effect of chronic exposure to hypoxia
    Alfredo Grilli
    Department of Biomorphology, Faculty of Medicine and Surgery, Universita degli Studi G D Annunzio, Chieti, Italy
    Ann Clin Lab Sci 33:208-15. 2003
    ..HO-1 helps to regulate vascular tone via CO and thereby participates in an important cardiac defense mechanism...
  98. ncbi request reprint Aspirin overprescription in primary cardiovascular prevention
    Costantina Manes
    Institute of Cardiology, G d Annunzio University Chieti, Italy
    Thromb Res 118:471-7. 2006
    ..We evaluated the inappropriateness of aspirin prescription by primary care physicians in primary cardiovascular prevention...
  99. ncbi request reprint Emergency coronary artery bypass grafting in patients with acute myocardial infarction treated with glycoprotein IIb/IIIa receptor inhibitors
    Marco De Carlo
    Cardiology Unit, Cardiothoracic Department, University of Pisa, Italy
    Int J Cardiol 123:229-33. 2008
    ....
  100. doi request reprint The C242T polymorphism of the p22phox component of NAD(P)H oxidase and vascular risk. Two case-control studies and a meta-analysis
    Augusto Di Castelnuovo
    Laboratory of Genetic and Environmental Epidemiology, Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    Thromb Haemost 99:594-601. 2008
    ....
  101. ncbi request reprint Recommendations for the management of patients after heart valve surgery
    Eric G Butchart
    Department of Cardiothoracic Surgery, University Hospital of Wales, Cardiff, UK
    Eur Heart J 26:2463-71. 2005
    ..Recommendations are therefore almost entirely based on non-randomized studies and relevant basic science...